Abstract: A process for decomposing formates in formate-containing compositions of matter comprises reacting formate-containing compositions of matter in the presence of at least one heterogeneous catalyst comprising lanthanum and at a temperature of from 80 to 180° C. and a pressure of from 0.1 to 60 bar, the formate-containing compositions of matter having a pH of from 6.5 to 10.

Abstract: The disclosure relates to a method for enhancing the biosynthesis and/or secretion of sapogenins in the culture medium of plant and microbial cell cultures. Further, the disclosure also relates to the identification of novel genes involved in the biosynthesis of sapogenin intermediates, as well as to novel sapogenin compounds.

Abstract: An aldehyde of formula (I) in the form of any one of its stereoisomers or a mixture thereof, wherein each dotted line, independently from each other, represents a single or double bond; n is 0 or 1; R1 is a hydrogen atom or a methyl group; R2 is a hydrogen atom or a methyl or ethyl group; and R3, which can be present in any of positions 2 to 6 of the cyclic moiety, is a hydrogen atom or a methyl or ethyl group, or a CH2 group bridging positions 3 and 6. Also, the use of the aldehyde as perfuming ingredient to impart odor notes of the aldehyde, lily of the valley type.

Abstract: The present disclosure provides novel glucagon-like peptide-1 (GLP-1) receptor modulators such as compounds of Formula (I) or (II), and pharmaceutically acceptable salts thereof. The present disclosure also provides pharmaceutical compositions, kits, and uses that involve the GLP-1 receptor modulators for regulating blood glucose levels and/or treating diabetes via, e.g., modulating the endogenous signaling pathways mediated by the GLP-1 receptor.

Abstract: The present disclosure provides methods of preparing glucagon-like peptide-1 (GLP-1) receptor modulators, such as compounds of Formula (II) or (VI), or intermediates thereof. The compounds that may be prepared by the described methods are useful for regulating blood glucose levels and/or treating a disease mediated by a GLP-1 receptor (e.g., diabetes).

Abstract: This invention addresses problems to provide a cyclic compound having a high solubility in safety solvents and a high sensitivity and being good in the shape of the resulting resist pattern, a method of producing the same, a radiation sensitive composition comprising the same, and a method of forming a resist pattern using the radiation sensitive composition. As means for solving the problem, there are provided a cyclic compound having a specific structure, a radiation sensitive composition comprising the compound, and a method of forming a resist pattern using the composition.

Abstract: The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, and wherein the dotted line may represents an additional bond and Ra represents a hydrogen atom or a Si(Rb)3 or (Rb)2COH group, each Rb representing C1-6 alkyl group or a phenyl group. The invention concerns also the compound (I) as well as its use for the synthesis of ?-santalol or of derivatives thereof.

Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.

Abstract: The present invention is directed to a novel fragrance compound of octahydro-6-methyl-4,7-methano-1H-indene-5-carboxaldehyde.

Abstract: The present invention is directed to a novel fragrance compound of octahydro-4,7-methano-1H-indene-5-acetaldehyde.

Abstract: The present invention refers to a process for the production of myrtanal from ?-pinene epoxide that comprises at least of putting this epoxide in contact with a microporous and crystalline catalyst with pores of a diameter of at least 0.52 nm with an empirical formula for the calcinated and dehydrated form of Hw(MwTixSnyZrzSi1-w-x-y-z)O2 where M is at least a metal with valence+3 selected from Al, B, Ga, Fe, Cr and combinations of these; w is a molar fraction of M with a value of between 0 and 2(x+y+z); x is a molar fraction of titanium and has a value of between 0 and 0.06; y is a molar fraction of tin and has a value of between 0 and 0.06; z is a molar fraction of zirconium and has a value of between 0 and 0.06; and where at least one of the three values “x”, “y” or “z” is different from zero. In the present invention, the microporous and crystalline catalyst preferably has pores of at least 0.52 nm and has a crystalline structure with an X-ray diffractogram of a zeolite beta.

Abstract: The present invention is directed to a novel fragrance compound of octahydro-4,7-methano-1H-indene-5-acetaldehyde, octahydro-6-methyl-4,7-methano-1H-indene-5-carboxaldehyde, or a mixture thereof.

Abstract: A compound for controlling blood glucose level has a structure shown in Formula I: wherein R5-R8 are as defined herein. A method for controlling blood glucose level includes administering to a subject in need thereof a compound of Formula I. The method further includes administering to the subject a GLP-1 receptor ligand. The compound and the GLP-1 receptor ligand may be administered together. The compound may be Galanal A or Galanal B. The GLP-1 receptor ligand may be GLP-1 or exendin-4.

Abstract: The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, and wherein the dotted line may represents an additional bond and Ra represents a hydrogen atom or a Si(Rb)3 or (Rb)2COH group, each Rb representing C1-6 alkyl group or a phenyl group. The invention concerns also the compound (I) as well as its use for the synthesis of ?-santalol or of derivatives thereof.

Abstract: The present invention is directed to a novel fragrance compound of octahydro-4,7-methano-1H-indene-5-acetaldehyde, octahydro-6-methyl-4,7-methano-1H-indene-5-carboxaldehyde, or a mixture thereof.

Abstract: Embodiments of the present disclosure include polycyclopentadiene compounds represented by Formula (I): in which each X is either a hydrogen or a cyano group (N?C—), n has an average value from zero to 20; each m independently has a value of zero to 3; p has a value of zero to 20; each R is independently a halogen, a nitrile group, a nitro group, an alkyl group, an alkoxy group, an alkenyl group, or an alkenyloxy group, where the alkyl group, the alkoxy group, the alkenyl group, and the alkenyloxy group each independently contain 1 to 6 carbon atoms; and each Q is independently hydrogen or an alkyl group containing 1 to 6 carbon atoms. Embodiments of the present disclosure also include a curable composition that includes the polycyclopentadiene compound(s) of Formula (I) and a curing amount of a resin or a catalyst amount of a catalyst and/or a cure accelerating amount of an accelerating agent.

Abstract: Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.

Abstract: The present invention refers to a process for the production of myrtanal from ?-pinene epoxide that comprises at least of putting this epoxide in contact with a microporous and crystalline catalyst with pores of a diameter of at least 0.52 nm with an empirical formula for the calcinated and dehydrated form of Hw(MwTixSnyZrzSi1-w-x-y-z)O2 where M is at least a metal with valence+3 selected from Al, B, Ga, Fe, Cr and combinations of these; w is a molar fraction of M with a value of between 0 and 2(x+y+z); x is a molar fraction of titanium and has a value of between 0 and 0.06; y is a molar fraction of tin and has a value of between 0 and 0.06; z is a molar fraction of zirconium and has a value of between 0 and 0.06; and where at least one of the three values “x”, “y” or “z” is different from zero. In the present invention, the microporous and crystalline catalyst preferably has pores of at least 0.52 nm and has a crystalline structure with an X-ray diffractogram of a zeolite beta.

Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

Abstract: The present invention claims fluoro- & iodo-containing aldehydes as ALDH substrates for use as diagnostic imaging agents or as therapeutic agents. The aldehydes are both directly and indirectly attached to an aromatic or a straight chain ring. ALDH activity was monitored either by the formation of acid-product or consumption of aldehyde substrates.

Abstract: This invention addresses problems to provide a cyclic compound having a high solubility in safety solvents and a high sensitivity and being good in the shape of the resulting resist pattern, a method of producing the same, a radiation sensitive composition comprising the same, and a method of forming a resist pattern using the radiation sensitive composition. As means for solving the problem, there are provided a cyclic compound having a specific structure, a radiation sensitive composition comprising the compound, and a method of forming a resist pattern using the composition.

Abstract: The present invention concerns a process for the preparation of a compound of formula (I), wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof.

Abstract: Described are 2,2,3-trimethylcyclopentane derivatives of formula 1 wherein R1 is methyl or ethyl; and R2 is hydrogen, methyl or ethyl. The invention furthermore relates to a method of their production a to fragrance compositions comprising them.

Abstract: The present invention provides a lubricating oil comprising an alicyclic compound represented by a general formula (I): wherein n is an integer of 0 or 1; one of R1 and R2 represents —CH2OR4 (wherein R4 represents a carboxylic acid residue) while the other one represents alkyl, lower alkyl-substituted or unsubstituted cycloalkyl, aryl, or aralkyl; and R3 represents —CH2OR5 (wherein R5 represents a carboxylic residue) and the like. The lubricating oil of the present invention has an excellent traction coefficient, excellent heat resistance, or the like. For the lubricating oil of the present invention, the alicyclic compound represented by the general formula (I) can be directly used as it is, and other base oils such as ester oil, poly-?-olefin, mineral oil, or silicone oil may be included therein, if necessary.

Abstract: The present invention relates to a method of functionalizing a carbon material. A carbon material is contacted with a carboxylic acid, whereby a mixture is formed. The mixture is heated for a suitable period of time at a temperature below the thermal decomposition temperature of the carbon material.

Abstract: This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour growth. Pharmaceutical compositions containing known adjutants and the title compounds are also within the scope of this invention.

Abstract: The present invention concerns a process for the preparation of a compound of formula (I), wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof.

Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.

Abstract: Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating, oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.

Abstract: The disclosed is about a hydroformylation of a cyclic olefin with rhodium catalyst, and specifically about the recovering of the rhodium catalyst. Aldehyde and the cyclic olefin are added into a rhodium catalyst solution to process a hydroformylation, thereby forming the product cycloalkyl aldehyde. Afterwards, the result is divided into two layers. The upper layer is substantially rhodium catalyst solution, and the lower layer is substantially cycloalkyl aldehyde and the aldehyde. After separation, the upper layer is reserved to process next hydroformylation reaction with newly added cyclic olefin.

Abstract: The present invention relates to a photochromic material comprising a proteorhodopsin apoprotein and a retinal analog. In one embodiment, the retinal analog is an azulenic retinoid compound. In another embodiment, the retinal analog is a compound that is structurally similarly to all-trans-retinal. The proteorhodopsin apoprotein and the retinal analog form a photochromic material having different spectral properties from those of a corresponding photochromic material formed by the same proteorhodopsin apoprotein and all-trans-retinal. In one embodiment of the application, the retinal analog-containing proteorhodopsin has an absorbance spectrum that does not overlap significantly with that of all-trans-retinal-containing proteorhodopsin. In another embodiment of the application, the retinal analog-containing proteorhodopsin yields a red-shifted visual chromophore compared with the all-trans-retinal-containing proteorhodopsin chromophore.

Abstract: The present invention provides a lubricating oil comprising an alicyclic compound represented by a general formula (I): wherein n is an integer of 0 or 1; one of R1 and R2 represents —CH2OR4 (wherein R4 represents a carboxylic acid residue) while the other one represents alkyl, lower alkyl-substituted or unsubstituted cycloalkyl, aryl, or aralkyl; and R3 represents —CH2OR5 (wherein R5 represents a carboxylic residue) and the like. The lubricating oil of the present invention has an excellent traction coefficient, excellent heat resistance, or the like. For the lubricating oil of the present invention, the alicyclic compound represented by the general formula (I) can be directly used as it is, and other base oils such as ester oil, poly-?-olefin, mineral oil, or silicone oil may be included therein, if necessary.

Abstract: The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 6 to 30 carbon atoms and containing single and/or double bonds.

Abstract: Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating, oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.

Abstract: Described are polyalkylbicylic chemical derivatives for use a fragrance ingredients having the generic structure: wherein m=0 or 1; wherein X is methyl or hydrogen; wherein R1, R2, R3 and R4 each represents methyl or ethyl with the proviso that when X is methyl, each of R1, R2, R3 and R4 is methyl and when X is hydrogen, one of R1, R2, R3 and R4 is ethyl; and wherein R6 represents hydrogen or methyl. Methods for using and making these compounds are also disclosed.

Abstract: The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 6 to 30 carbon atoms and containing single and/or double bonds.

Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Abstract: Methods, compositions, and devices for alleviating the problems of toxic discharge of aldehydes present in waste streams are disclosed. The methods relate to forming neutralized aldehydes by treating aldehydes with oxidizing agents. The oxidizing agents offer a simple, effective, fast and inexpensive solution for treatment of toxic aldehydes prior to disposal into the environment.

Abstract: A process for selectively hydroformylating dicyclopentadiene to 8(9)-formyltricyclo-[5.2.1.02,6]dec-3-ene in a heterogeneous reaction system using an aqueous solution of transition metal compounds, containing water-soluble organic phosphorus(III) compounds in complex-bound form, of group VIII of the Periodic Table of the Elements, wherein the water-soluble organic phosphorus(III) compounds are alkali metal or alkaline earth metal salts of sulfonated arylphosphines and aryldiphosphines.

Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Abstract: The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 1 to 30 carbon atoms and containing single and/or double bonds.

Abstract: A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation.

Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.

Abstract: A process for preparing 3(4),8(9)-bisformyltricyclo[5.2.1.02.6]decane by hydroformylating dicyclopentadiene with subsequent distillation wherein the hydroformylation of dicyclopentadiene is carried out in two stages, and, in the first hydroformylation stage, the reaction is effected in a heterogeneous reaction system using an aqueous solution of transition metal compounds, containing water-soluble organic phosphorus (III) compounds in complex-bound form, of group VIII of the Period Table of the Elements to give 8(9)-bisformyltricyclo[5.2.1.02.6]dec-3-ene, and, in a second hydroformylation stage, the thus obtained 8(9)-bisformyltricyclo[5.2.1.02.6]dec-3-ene is converted, in homogeneous organic phase in the presence of transition metal compounds of group VIII of the Periodic Table of the Elements to 3(4),8(9)-bisformyltricyclo[5.2.1.02.6]decane.

Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-containing diene obtained in step (a) or a commercially available saccharide-containing diene with a dienophile by Diels-Alder reaction.

Abstract: Aldehydes containing a difluorooxymethylene bridge, of the general formula I

Abstract: Novel and nonobvious compounds that function, alone or in combination, as nuclear hormone receptors for the stimulation and/or improvement of murine, mammalian skin. Specifically, beta-ionol analog and fatty acid analog compounds that are believed to function as RXR, RAR and/or PPAR receptor ligands to encourage skin differentiation and discourage excess skin proliferation. The present invention further relates to one or more products, consumer and otherwise, comprising the novel, nuclear hormone receptor ligands disclosed herein.

Abstract: This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the construction of other enantio-enriched compounds.

Abstract: New antitumor compounds isolated from a sponge are of the a formulae (1), (2), (3) and (4).

Abstract: Acid addition salts of imidazolidinones are provided as catalysts for transforming a functional group within a first reactant by reaction with a second reactant. Exemplary first reactants are &agr;,&bgr;-unsaturated carbonyl compounds such as &agr;,&bgr;-unsaturated ketones and &agr;,&bgr;-unsaturated aldehydes. Chiral imidazolidinone salts can be used to catalyze enantioselective reactions, such that a chiral product is obtained from a chiral or achiral starting material in enantiomerically pure form.