Sulfur, Oxygen, Halogen Or Group Ia Or Iia Light Metal Containing Patents (Class 568/5)
-
Publication number: 20150144927Abstract: An organic electroluminescence (EL) device includes a charge generating layer including a charge generating material or a hole injection layer including a hole injection material, the charge generating material or the hole injection material including a 1,2-closo-carborane compound represented by the following Formula 1: wherein each Ar1 is independently a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group.Type: ApplicationFiled: November 26, 2014Publication date: May 28, 2015Applicant: NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITYInventors: Xiulan JIN, Junji KIDO, Hisahiro SASABE, Kazuo UDAGAWA
-
Publication number: 20140303390Abstract: Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.Type: ApplicationFiled: October 24, 2012Publication date: October 9, 2014Applicants: UNIVERZITA PALACKEHO V OLOMOUCI, USTAV ORGANICKE CHEMIE A BIOCHEME AKADEMIE VED CESKE REPUBLIKY, v.v.i., USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY, v.v.iInventors: Jiri Brynda, Petr Cigler, Bohumir Gruner, Pavlina Maloy Rezacova, Pavel Mader, Vaclav Sicha, Mario Bakardjiev, Josef Holub, Petr Dzubak, Marian Hajduch
-
Publication number: 20140239191Abstract: The uninterrupted production of an ion beam with self-cleaning of a discharge chamber and extractor system, including extraction aperture(s), of an ion implantation device. The method increases the time of continuous operation of the ion implantation device, and therefore, increases total implantation time without reducing intensity. As a result, the time integrated output of the ion implantation device is increased. The method includes feeding a working molecule comprising at least two boron atoms and a strong oxidizer into an ion implantation device and removing gaseous compounds from the ion implantation device, wherein said working molecule provides upon fragmentation a polyatomic boron-containing ion, and the strong oxidizer which reacts with solid products of decomposition of the working molecule to form said gaseous compounds. A working molecule including at least two boron atoms and at least one strong oxidizer is also disclosed.Type: ApplicationFiled: July 20, 2012Publication date: August 28, 2014Inventors: Ady Itzchak Hershcovitch, Oleg Alexeyenko, Timur Kulevoy, Rostislav Kuibeda, Efim Oks, Vasiliy Gushenets, Pavel Storozhenko, Ella Gurkova, Sergey Dugin, Gennady Kropachev, Dimitri Seleznev
-
Patent number: 8741250Abstract: The present invention relates to a synthetic method for producing a per-hydroxylated icosahedral boron compound via catalytic hydroxylation of icosahedral boron compound using a soft electrophile.Type: GrantFiled: August 3, 2012Date of Patent: June 3, 2014Assignee: The Curators of the University of MissouriInventors: M. Frederick Hawthorne, Oleg Bondarev
-
Patent number: 8680265Abstract: Processes are disclosed for the preparation of a compound having the formula: (I) and intermediate compounds wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH2)nC2HB9H10 or O(CH2)nC2HB10H10 wherein n is 0 or an integer from 1 to 20 and O(CH2)nC2HB9H10 is nido ortho-, meta- or para-carborane and O(CH2)nC2HB10H10 is ortho-, meta- or para-carborane.Type: GrantFiled: December 13, 2005Date of Patent: March 25, 2014Assignee: PSIMEI PharmaceuticalsInventors: Paul Stanley Bury, Ke-Dong Li, Anthony David Bentham, Bipin Chandra Muljibhai Patel
-
Patent number: 8372369Abstract: Methods for enhancing hydrogen spillover and storage are disclosed. One embodiment of the method includes doping a hydrogen receptor with metal particles, and exposing the hydrogen receptor to ultrasonication as doping occurs. Another embodiment of the method includes doping a hydrogen receptor with metal particles, and exposing the doped hydrogen receptor to a plasma treatment.Type: GrantFiled: April 20, 2011Date of Patent: February 12, 2013Assignee: The Regents of The University of MichiganInventors: Ralph T. Yang, Yingwei Li, Anthony J. Lachawiec, Jr.
-
Publication number: 20120244690Abstract: According to certain embodiments, a resist is placed over the surface of a semiconductor structure, wherein the resist covers a portion of the semiconductor structure. Dopants are implanted into the semiconductor structure using an ion implantation beam in regions of the semiconductor structure not covered by the resist. Due to exposure to the ion implantation beam, at least a portion of the resist is converted by exposure to the ion beam to contain an inorganic carbonized material. The semiconductor structure with resist is contacted with a superacid composition containing a superacid species to remove the resist containing inorganic carbonized materials from the semiconductor structure.Type: ApplicationFiled: March 23, 2011Publication date: September 27, 2012Applicant: TOSHIBA AMERICA ELECTRONIC COMPONENTS, INC.Inventor: Yoshihiro Uozumi
-
Publication number: 20110230678Abstract: Disclosed is an organic framework including: planar layers formed by successively connecting building blocks arranged in the vicinity of each other, in which each of the building blocks includes two or three C6 to C204 aromatic ring groups covalently bonded to a linear or annular boron-containing cluster; and a Lewis base coordinated to the boron-containing cluster within the planar layers.Type: ApplicationFiled: November 17, 2009Publication date: September 22, 2011Applicant: INSILICOTECH CO., LTDInventors: Dong Hyun Jung, Minkyoung Kim, Daejin Kim, Seung-Hoon Choi, Jihye Yoon, Sang Beom CHoi, Eunhee Jo, Jaheon Kim
-
Patent number: 8013190Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.Type: GrantFiled: January 27, 2005Date of Patent: September 6, 2011Assignees: Vysoka Skola Chemicko-Technologicka V Praze, Ustav Organicke Chemie A Biochemie AV CZ, Ustav Anorganicke Chemie AV CZ, Department of Virology, University of HeidelbergInventors: Vladimír Král, Petr Cigler, Jan Konvalinka, Milan Kozísek, Jana Prejdová, Bohumír Grüner, Jaromír Plesek, Martin Lepsík, Jana Pokorná, Hans-Georg Kräusslich, Jochen Bodem
-
Publication number: 20110184175Abstract: Disclosed is a method for producing a BSH derivative, which comprises a step of addition-reacting BSH with an ?,?-unsaturated nitrile compound in the presence of a base. Various BSH derivatives obtained by the method are also disclosed.Type: ApplicationFiled: July 23, 2009Publication date: July 28, 2011Applicant: STELLA PHARMA CORPORATIONInventors: Mitsunori Kirihata, Tomoyuki Asano, Kohki Uehara, Yoshihide Hattori
-
Patent number: 7737234Abstract: Provided is a method for polymerizing a polymer precursor, comprising: contacting a polymer precursor with a lithium carborane catalyst and an initiator under polymerizing conditions. A reaction solvent may be used, but is not necessary. Also provided is a method of preparing lithium carborane polymers, comprising: contacting a lithium carborane polymer precursor having a terminal alkenyl or alkynyl group with an initiator and an optional reaction solvent under polymerizing conditions. Functionalized carborane anions are also provided.Type: GrantFiled: August 4, 2006Date of Patent: June 15, 2010Assignee: The Regents of the University of Colorado, a body corporateInventors: Josef Michl, Kamesh Vyakaranam, Stefanie Koerbe
-
Publication number: 20100016613Abstract: Processes are disclosed for the preparation of a compound having the formula: (I) and intermediate compounds wherein M is a single-photon-emission tomography imageable radiometal and/or a paramagnetic metal, R is hydrogen or a halogen provided that at least one R is halogen and Y is selected from ortho, meta or para O(CH2)nC2HB9H10 or O(CH2)nC2HB10H10 wherein n is 0 or an integer from 1 to 20 and O(CH2)nC2HB9H10 is nido ortho-, meta- or para-carborane and O(CH2)nC2HB10H10 is ortho-, meta- or para-carborane.Type: ApplicationFiled: December 13, 2005Publication date: January 21, 2010Applicant: PSIMEI PHARMACEUTICALS PLCInventors: Paul Stanley Bury, Ke-Dong Li, Anthony David Bentham, Bipin Chandra Muljibhai Patel
-
Publication number: 20090317920Abstract: The present invention is a compound having a structure represented by the following formula (1): and an antibody to BSH obtained by using the compound as a hapten and using a complex of the hapten and a high-molecular compound as an antigen. By using the present invention, it becomes possible to provide a hapten compound for preparing an antibody recognizing BSH highly sensitively and highly selectively, an antibody to BSH, as well as a kit for measuring BSH and an immunological measuring method having high sensitivity and excellent in quantitative property using the antibody.Type: ApplicationFiled: October 5, 2006Publication date: December 24, 2009Applicant: STELLA CHEMIFA CORPORATIONInventors: Mitsunori et al. Kirihata, Tomoyuki Asano, Kohki Uehara
-
Patent number: 7572458Abstract: Provided are a boron compound-layered double hydroxide (LDH) nanohybrid in which a boron compound for boron neutron capture therapy is intercalated in between layers of LDH, a method of preparing the boron compound-LDH nanohybrid, and a pharmaceutical composition including the boron compound-LDH nanohybrid, which can be used in boron neutron capture therapy.Type: GrantFiled: June 11, 2008Date of Patent: August 11, 2009Assignee: Ewha University-Industry Collaboration FoundationInventors: Jin Ho Choy, Ie Rang Jeon, Soo Jin Choi, Jae Min Oh
-
Patent number: 7563934Abstract: A method for producing MnB12H12, wherein M is a metal or ammonium cation and n is one or two, by combining a metal borohydride and XBH3; wherein X is a substituted amine; a substituted phosphine; or tetrahydrofuran.Type: GrantFiled: November 3, 2008Date of Patent: July 21, 2009Assignee: Rohn and Haas CompanyInventors: Rajiv Manohar Banavali, Randall Wayne Stephens, John Hiroshi Yamamoto
-
Publication number: 20090012044Abstract: The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, ?1 or ?2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.Type: ApplicationFiled: January 27, 2005Publication date: January 8, 2009Applicants: VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE, USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CZ, USTAV ANORGANICKE CHEMIE AV CZ, DEPARTMENT OF VIROLOGY, UNIVERSITY OF HEIDELBERGInventors: Vladimir Kral, Petr Cigler, Jan Konvalinka, Milan Kozisek, Jana Prejdova, Bohumir Gruner, Jaromir Plesek, Martin Lepsik, Jana Pokorna, Hans-Georg Krausslich, Jochen Bodem
-
Patent number: 7084133Abstract: A compound represented by the following general formula (I), wherein R1 represents a hydroxy-substituted alkyl group, a hydroxy-substituted alkenyl group, a hydroxy-substituted arylalkyl group (said arylalkyl group may have a substituent on the aryl ring), or a hydroxy-substituted arylalkenyl group (said arylalkenyl group may have a substituent on the aryl ring); X represents a dicarba-closo-dodecaborane-diyl group; R2 represents a hydroxy-substituted alkyl group or a hydroxy-substituted alkoxyalkyl group, or a salt thereof, which is useful as an agent exerting vitamin D actions or an agent for enhancing vitamin D actions R1—X—R2.Type: GrantFiled: February 8, 2002Date of Patent: August 1, 2006Inventor: Hiroyuki Kagechika
-
Patent number: 7067653Abstract: The invention describes the synthesis of a panel of novel carbon-carbon linked carboranyl-containing 5,10,15,20-tetraphenylporphyrins bearing 25–44% boron by weight. In certain embodiments, a phenyl porphyrin compound has a carboranyl group attached to the phenyl group by a carbon-carbon linkage, wherein the phenyl group corresponds to the following formula where R7 through R11 are hydrogen, a carboranyl group, or are selected from the group consisting of hydroxyl, NMe3+, PMePh2+, PO(OH)2, SO3H, COOH, and NH2. In this embodiment, the carboranyl group is attached to the phenyl group by a carbon-carbon linkage, either one or two of R7 through R11 are other than hydrogen; and the phenyl porphyrin compound contains at least one phenyl group having at least one of said carboranyl groups.Type: GrantFiled: May 9, 2001Date of Patent: June 27, 2006Assignee: The Regents of the University of CaliforniaInventors: Maria Da Graca H. Vicente, Shankar Jayaram Shetty, Laurent Jaquinod, Kevin M. Smith
-
Patent number: 6992224Abstract: Present invention relates to a process for the manufacture of fluorinated alcohols as well as borates which are employed in the manufacture of the fluorinated alcohols. Fluorinated alcohols of the formulae HOCHRCF(CF3)CHFCF(CF3)2 and HOCHRCF(CF(CF3)2)CHFCF3, HOCHRCF(CF2CF3)CH(CF3)2 and HOCHRC(CF3)2CHFCF2CF3 are made by heating a mixture of a borate of the formula (RCH2O)3B, wherein R?H or a C1 to C7 alkyl group, with perfluoro-4-methyl-2-pentene or perfluoro-2-methyl-2-pentene and a free-radical initiator to form a mixture of borates, optionally separating the mixture of borates from any reactants, solvents, and by-products; hydrolyzing the mixture of borates to form a hydrolysis product mixture; and separating the alcohols from the hydrolysis product mixture.Type: GrantFiled: May 12, 2004Date of Patent: January 31, 2006Assignee: Honeywell International Inc.Inventors: Michael Van Der Puy, Jingji Ma, George J. Samuels, Leonard M. Stachura
-
Publication number: 20040038127Abstract: The present invention is directed to the use of a new ambient temperature molten salt as an electrolyte for electrochemical energy storage devices, such as electrochemical cells and electrolytic capacitors. The ambient temperature molten salt comprises an imide cation combined with a small anion. A particularly preferred anion is bis-trifluoromethanesulfonyl imide. The electrolyte is useful with electrochemical devices such as primary and secondary electrochemical cells and capacitors of the electrolytic and electrolytic/electrochemical hybrid types.Type: ApplicationFiled: August 15, 2003Publication date: February 26, 2004Inventor: Carl Roger Schlaikjer
-
Patent number: 6664426Abstract: New boron icosahedral ethers and esters formed from Cs2[closo-B12(OH)12],; Cs[closo-1-H-1-CB11(OH)11]; and closo-1,12-H2-1,12-C2B10(OH)10 are disclosed. Also set forth are their preparation by reacting the icosahedral boranes [closo-B12H12]2−, [closo-1-CB11H12]− and closo-1,12-(CH2OH)2-1,12-C2B10H10 with an acid anhdride or acid chloride to form the ester or an alkylating agent to form the ether.Type: GrantFiled: June 12, 2000Date of Patent: December 16, 2003Assignee: The Regents of the University of CaliforniaInventors: M. Frederick Hawthorne, Toralf Peymann, Andreas Maderna
-
Patent number: 6645903Abstract: The present invention provides catalyst components comprising a compound having a weakly coordinating anion salt and a reactive cation, in particular a compound of the formula MxQy. Preferably, each M is independently a cation with at least one M being a reactive cation as defined herein. Q is a fluorinated polyhedral borate moiety. And x and y are absolute values of the oxidation states of Q and M, respectively. The present invention also provides processes for using the catalyst components defined herein.Type: GrantFiled: July 25, 2002Date of Patent: November 11, 2003Assignee: Colorado State University Research FoundationInventors: Steven H. Strauss, Sergei V. Ivanov
-
Patent number: 6525224Abstract: A polyhedral borane cluster consists essentially of a fused polyhedron including an open decaborane cage fused to a closed dodecaborane cluster wherein borane atoms are not an integral part of the cluster vertices. The polyhedral borane cluster can be contained within a biomolecule for use as a neutron capture reagent. A method of synthesizing the polyhedral borane cluster includes the step of fusing an open decaborane cage to a closed dodecaborane cluster.Type: GrantFiled: June 7, 2000Date of Patent: February 25, 2003Assignee: Northern Illinois UniversityInventors: Bernard F. Spielvogel, Narayan Hosmane
-
Patent number: 6521604Abstract: The invention relates to a compound which contains boron and which comprises the following general formula (1) in which Cb represents carborane, R2 and R3, independent of one another, represent a hydrogen atom or an organic radical, and R and R1, independent of one another, represent a hydrogen atom or an organic group, or R and R1 form a carbonyl group with the carbon atom to which they are bound. The invention also relates to a method of producing a compound containing boron and to the application of the same.Type: GrantFiled: December 15, 2000Date of Patent: February 18, 2003Assignee: Deutches KrebsforschungszentrumInventors: Manfred Wiessler, Helmut Tröster, Stefan Raddatz, Eberhard Spiess, Michael Trendelenburg
-
Patent number: 6448447Abstract: The present invention provides weakly coordinating anion salts comprising a reactive cation and uses thereof. In particular, the present invention provides compounds of the formula MxQy and uses thereof. Preferably, each M is independently a cation with at least one M being a reactive cation as defined herein. Q is a fluorinated polyhedral borate moiety. And x and y are absolute values of the oxidation states of Q and M, respectively.Type: GrantFiled: October 31, 2000Date of Patent: September 10, 2002Assignee: Colorado State University Research FoundationInventors: Steven H. Strauss, Sergei V. Ivanov
-
Patent number: 6323372Abstract: New icosahedral borohydrates Cs2[closo-B12(OH)12]; Cs[closo-1-H-1-CB11(OH)11]; and closo-1,12-H2-1,12-C2B10(OH)10 are disclosed. Also set forth are their preparation by refluxing the icosahedral boranes [closo-B12H12]2−, [closo-1-CB11H12]− and closo-1,12-(CH2OH)2-1,12-C2B10H10 with a hydroxylating agent, preferably 30%w hydrogen peroxide.Type: GrantFiled: April 10, 2000Date of Patent: November 27, 2001Assignee: The Regents of the University of CaliforniaInventors: M. Frederick Hawthorne, Toralf Peymann, Axel Hans-Joachim Herzog
-
Patent number: 6180829Abstract: The present invention provides compounds comprising a polyhalogenated heteroborane anion of the formula RaZBbHcFdXe(OR″)f−1, and a method for producing the same. Specifically, the present invention provides compounds comprising a polyfluorinated monocarborane anion.Type: GrantFiled: December 17, 1999Date of Patent: January 30, 2001Assignee: Colorado State University Research FoundationInventors: Steven H. Strauss, Sergei V. Ivanov, Anthony J. Lupinetti
-
Patent number: 6143264Abstract: Process for the preparation of undecahydrododecaborate anions [B.sub.12 H.sub.(12-n) (XCN).sub.n ].sup.2- or [B.sub.12 H.sub.11 XH].sup.2- or a nonahydrodecaborate anions [B.sub.10 H.sub.(12-n) (XCN).sub.n ].sup.2- or [B.sub.10 H.sub.9 XH].sup.2- or anions of formula [B.sub.12 H.sub.11 SC(NR.sup.1 R.sup.2).sub.2 ].sup.-1 wherein X=O, S, or Se.Type: GrantFiled: August 26, 1998Date of Patent: November 7, 2000Assignee: The University of StrathclydeInventors: Victor Alexandrovich Brattsev, John Howell Morris
-
Patent number: 6130357Abstract: The present invention provides compounds comprising a polyhalogenated heteroborane anion of the formula R.sub.a ZB.sub.b H.sub.c F.sub.d X.sub.e (OR").sub.f.sup.-1, and a method for producing the same. Specifically, the present invention provides compounds comprising a polyfluorinated monocarborane anion.Type: GrantFiled: March 27, 1998Date of Patent: October 10, 2000Assignee: Colorado State University Research FoundationInventors: Steven H. Strauss, Sergei V. Ivanov, Anthony J. Lupinetti
-
Patent number: 6037490Abstract: Novel compounds which are useful for boron neutron capture therapy (BNCT) are disclosed. The compounds comprise a stable boron-containing group and an aminocycloalkane carboxylic acid group or a boronated acyclic hydrocarbon-linked amino carboxylic acid. Methods for synthesis of the compounds and for use of the compounds in BNCT are disclosed.Type: GrantFiled: September 3, 1997Date of Patent: March 14, 2000Assignee: The University of Tennessee Research CorporationInventors: George W. Kabalka, Rajiv R. Srivastava
-
Patent number: 5807905Abstract: Compounds of the formula I ##STR1## in which n and o are a number from 0 to 50, m is a number from 1 to 50, u and v are 0 or 1, and at least one of the indices u and v is 1, R.sub.1, R.sub.2, R.sub.2a, R.sub.3 and R.sub.4 independently of one another are, for example, aromatic hydrocarbons, R.sub.5, if n and o are 0, is for example C.sub.1 -C.sub.12 alkyl and, if n and/or o are greater than 0, or if n and o are 0 and at the same time only one index u or v is 1, R.sub.5 may additionally, for example, be an aromatic hydrocarbon, at least one of the radicals R.sub.1, R.sub.2, R.sub.2a, R.sub.3, R.sub.4 and R.sub.5 being an aromatic hydrocarbon radical which is sterically hindered ortho to the boron atom, X is, for example, C.sub.1 -C.sub.20 alkylene, phenylene, biphenylene, etc., and Z is a radical which is able to form positive ions, are suitable as photoinitiators, both the compounds per se and their combination with dyes or other electron acceptors.Type: GrantFiled: November 21, 1996Date of Patent: September 15, 1998Assignee: Ciba Specialty Chemicals CorporationInventors: Allan Francis Cunningham, Martin Kunz, Hisatoshi Kura
-
Patent number: 5731470Abstract: Substituted borate and carborate anions having unusual properties of being exceptionally weakly nucleophilic and being soluble in non-polar solvents. One-electron oxidation of the anions yields the corresponding radicals. The compounds are useful, e.g., as electrolytes, catalysts, and electrochromic materials.Type: GrantFiled: April 5, 1996Date of Patent: March 24, 1998Assignee: Board of Regents of the University of ColoradoInventors: Josef Michl, Benjamin T. King, Zbynek Janousek
-
Patent number: 5648532Abstract: Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.Type: GrantFiled: June 3, 1993Date of Patent: July 15, 1997Assignee: The Regents of the University of CaliforniaInventors: M. Frederick Hawthorne, Debra Arliene Feakes, Kenneth John Shelly
-
Patent number: 5612017Abstract: A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.Type: GrantFiled: April 24, 1995Date of Patent: March 18, 1997Assignee: Associated Universities, Inc.Inventors: Michiko Miura, Daniel N. Slatkin
-
Patent number: 5252237Abstract: Alkoxy borates of alkylated phenols have been found to be effective cleanliness agents for lubricants and additives for improving the dropping point of greases.Type: GrantFiled: August 3, 1992Date of Patent: October 12, 1993Assignee: Mobil Oil CorporationInventors: Harry J. Andress, Jr., Henry Ashjian, William F. Olszewski, Robert E. Ernhoffer
-
Patent number: 5116980Abstract: The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.Type: GrantFiled: February 25, 1991Date of Patent: May 26, 1992Assignee: The United States of America as represented by the United States Department of EnergyInventor: Detlef Gabel
-
Patent number: 5102569Abstract: A method of preparing a borated alkylcatechol by first reacting catechol with boric acid and thereafter alkylating with an olefin.Type: GrantFiled: October 23, 1990Date of Patent: April 7, 1992Assignee: Chevron Research and Technology CompanyInventors: Anatoli Onopchenko, Thomas V. Liston
-
Patent number: 5021572Abstract: The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.Type: GrantFiled: January 27, 1989Date of Patent: June 4, 1991Assignee: The United States Department of EnergyInventor: Detlef Gabel
-
Patent number: 4444972Abstract: Carboranylmethylene-substituted cyclophosphazenes which can be thermally polymerized into carboranylmethylene-substituted phosphazene polymers, useful as thermally stable coatings and, due to the characteristics of these polymers in acting as a ligand for transition metals, metallocarboranylmethylene phosphazene polymers which can act as immobilized catalyst systems, and are electrically conductive and superconductive.Type: GrantFiled: May 3, 1983Date of Patent: April 24, 1984Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Harry R. Allcock, Angelo G. Scopelianos
-
Patent number: 4391993Abstract: Disclosed is an improved method and the thermolysis equipment setup for certing tetraethylammonium tetrahydridoborane to bis(tetraethylammonium) decahydrodecaborane by a thermolysis reaction which increases the yield in the range between about 22% to 64%, and, perhaps higher. The heat transfer control is maintained by employing triethylamine borane in the reaction mixture between about 175.degree. C. and 186.degree. C. for a reaction time from about 1 hour to about 2.5 hours. The disclosed thermolysis procedure is successful in dissipating a major portion of the exothermic heat. The control of the generated heat serves to minimize the formation of the byproduct bis(tetraethylammonium) dodecahydrododecaborane while increasing the yield of the desired product, bis(tetraethylammonium) decahydrodecaborane.Type: GrantFiled: February 12, 1982Date of Patent: July 5, 1983Assignee: The United States of America as represented by the Secretary of the ArmyInventor: David C. Sayles
-
Patent number: 4288585Abstract: Carboranyl-substituted polyphosphazenes are prepared by heat polymerizing a carboranyl halocyclophosphazene at 250.degree. C. for about 120 hours in the absence of oxygen and moisture. The cyclophosphazene is obtained by allowing a lithium carborane, e.g. the reaction product of methyl-o-carborane with n-butyllithium in ethyl ether, to react with e.g. hexachlorocyclotriphosphazene at ambient temperatures and in anhydrous conditions. For greater stability in the presence of moisture, the chlorine substituents of the polymer are then replaced by aryloxy or alkoxy groups, such as CF.sub.3 CH.sub.2 O--.The new substantially inorganic polymers are thermally stable materials which produce a high char yield when exposed to extreme temperatures, and can thus serve to insulate less heat and fire resistant substances.Type: GrantFiled: March 12, 1980Date of Patent: September 8, 1981Inventors: Robert A. Administrator of the National Aeronatuics and Space Administration, with respect to an invention of Frosch, Harry R. Allcock, John P. O'Brien, Angelo G. Scopelianos, Larry L. Fewell