Abstract: Hydroxy arylcyclobutenes are prepared by the Baeyer-Villiger oxidation of arylcyclobutene aldehydes with permonophosphoric acid.

Abstract: This invention concerns compounds having the structure: ##STR1## wherein each of R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.2', R.sup.3', R.sup.4', and R.sup.5', is independently hydrogen (--H), or a hydroxyl (--OH), methoxy (--OMe), methyl (--Me), carboxaldehyde (--CHO) or phenylformazen (Ph--N.dbd.CH--) group.This invention also provides a novel process of synthesizing the compounds of the subject invention, including intermediate compounds useful in the process.The present invention also provides pharmaceutical compositions comprising a pharmaceutically effective amount of a compound according to the subject invention and a pharmaceutically acceptable carrier. Finally, the invention provides spermicidal methods and methods of killing or of retarding the proliferation of, cancer cells.

Abstract: Process for the alkylation of phenols comprising reacting a phenol with a vinyl-aromatic hydrocarbon in the presence of an acidic catalyst and of a solvent.

Abstract: A 5,6,7,8-tetrahydro-1-naphthalenol derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent lower alkyl,R.sub.5 and R.sub.6 represent hydrogen or lower alkyl,R represents hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkyl substituted by one or more hydroxyl groups, C.sub.3 -C.sub.18 alkenyl, C.sub.2 -C.sub.18 acyl, benzyl, benzoyl, carboxyl and carboxylic salts of an alkali or alkaline earth metal or of an organic amine.The derivative is useful as an antioxidant in cosmetic compositions and in pharmaceutical compositions for the preventive treatment of cutaneous inflammations and allergies or certain forms of cancer.

Abstract: Novel styryl-tetrahydronaphthalene and indane derivatives useful for treating neoplasms and dermatoses.

Abstract: This invention is addressed to antioxidants which are polymerizable using the Ziegler catalyst system. The antioxidant of the present invention has the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each aryl groups containing a hindered antioxidant structure imparting antioxidant properties to the compounds. The compounds of the present invention are useful in the polymerization of olefin compounds using Ziegler catalyst systems whereby the antioxidant of the invention becomes chemically bound to the polymer while, at the same time, imparting antioxidant properties thereto.

Abstract: 4-Methyl-2-cyclohexylphenol can be prepared by alkylation of p-cresol with cyclohexanol or cyclohexene by performing the reaction in the liquid phase in the presence of 1-10% by weight, based on the amount of p-cresol, of a large pore, acidic zeolite.

Abstract: Novel styryl-tetrahydromaphthalene and indane derivatives useful for treating neoplasms and dermatoses.

Abstract: Ortho-aromatic diaryl ethers, such as o-biphenylyl phenyl ether, are hydrolyzed to corresponding phenolic compounds, such as o-phenylphenol and phenol, when contacted with water in the presence of ceria or thoria at a temperature of between about 250.degree. C. and 700.degree. C.

Abstract: Compounds having the formula ##STR1## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.

Abstract: A method is provided for the production of optically active (S)-(-)- and (R)-(+)-binaphthol and catalyzed asymmetric hydrolysis of corresponding racemic (R,S)-(.+-.)-binaphthol an (R,S)(.+-.)-spirobiindanol diesters.

Abstract: A novel compound, 4-(4-hydroxyphenyl)-3-cyclohexene-1-ol, and a novel preparation process of 4,4'-biphenol by using the novel compound as the raw material.4-(4-Hydroxyphenyl)-3-cyclohexene-1-ol can be obtained by conducting a thermal decomposition reaction of 4,4-bis(4-hydroxyphenyl)cyclohexanol. 4,4'-Biphenol can be industrially manufactured by conducting a dehydrogenation reaction of 4-(4-hydroxyphenyl)-3-cyclohexene-1-ol.

Abstract: Colloidal suspensions of charged polymer particles containing charged metal complexes are prepared from charged polymer colloids by ion exchange. The charged polymer latex particles containing the metal complex are characterized as ranging from about 0.01 to 1.5 micrometers in diameter and containing from about 0.01 to 3.0 millimoles of metal complex per gram of dry polymer and are useful for catalysis of chemical reactions in aqueous dispersions.

Abstract: The phenol compound of the present invention can be readily produced by, for example, reacting glyoxal, glutaraldehyde or crotonaldehyde with particular phenols. The phenol compound of the present invention is useful not only as a developer but also as an antioxidant for, e.g., synthetic resins and as an intermediate in the production of medicines or agricultural chemicals.The heat-sensitive recording material of the present invention, which contains the phenol compound as described above, shows little discoloration of the developed color and little coloration of the ground even at a high temperature and high humidity. Thus it is highly superior to conventional ones.

Abstract: The present invention relates to new synthetic compounds of the cannabinoid class, specifically carenadiol and its derivatives. This compound and its derivatives have been shown to have biological activity which indicates their usefulness in the treatment of patients with various neurological disorders.

Abstract: Perfume compositions and perfumed articles containing dihydro- and/or tetrahydro-1-naphthol derivatives of the formula ##STR1## wherein the dotted lines represent carbon-carbon single or double bonds with the proviso that no more than one of them is a double bond and wherein R.sub.1, R.sub.2 and R.sub.3 independently are methyl groups or hydrogen atoms; said naphthol derivatives have a very natural leather-like odor.

Abstract: 1,4-dihydroxy, 5,8-dihydronaphthalene and related compounds are provided from benzoquinone, and 1,3-butadiene which may be substituted with halogen, acyl, and alkyl, in a one step reaction in the presence of a ferric salt catalyst.

Abstract: Novel compounds of the following general formula: ##STR1##

Abstract: Compounds having the formula ##STR1## wherein ##STR2## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.

Abstract: Novel compounds of the following general formula: ##STR1##

Abstract: The invention is a process for the preparation of an aromatic hydrocarbon with a cyclobutene ring fused to the aromatic hydrocarbon which comprises, dissolving an ortho alkyl halomethyl aromatic hydrocarbon in an inert solvent and pyrolyzing the solution of ortho alkyl halomethyl aromatic hydrocarbon in the inert solvent under conditions such that the ortho alkyl and halomethyl substituents form a cyclobutene ring thereby forming an aromatic hydrocarbon having a fused cyclobutene ring.

Abstract: Novel compounds of the following general formula: ##STR1##

Abstract: Olefins are produced by containing an organic compound having at least one benzene ring with ethylenediamine and calcium metal, the calcium metal being used in large excess or alternatively in conjunction with an inert abrasive particulate substance. Substantially all of the organic compounds are converted to corresponding cyclic olefins, largely mono-olefins.

Abstract: In the production of 1,1-dimethyl-6-hydroxyindans through the reaction of phenols with isoprene or 2,3-dimethyl-1,3-butadiene in the presence of phosphoric acid, an improvement is comprised of using a phosphoric acid concentration of about 100% instead of 85% or less and also of the distillation of the product mixture from a solution containing phosphoric acid of about 95% concentration.

Abstract: Novel compounds of the following general formula: ##STR1##

Abstract: Novel compounds of the following formula: ##STR1##

Abstract: Novel compounds of the following general formula: ##STR1##

Abstract: Compounds having the formula ##STR1## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ--W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.

Abstract: Novel compounds of the following general formula: ##STR1##

Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

Abstract: Indene compounds of the formula ##STR1## wherein X represents a hydrogen atom, a halogen atom, a hydroxyl group or a methyl group, and y is 0 or an integer of 1 to 3, are produced by either heat-decomposing indene compounds of the formula ##STR2## wherein X and y are as defined, in the presence of an acid or alkaline catalyst; or heat-decomposing isopropenyl phenols of the formula ##STR3## wherein X and y are as defined, or oligomers or polymers thereof in the presence of an acid catalyst. 5-Hydroxy-1,1,3-trimethyl-2-indene corresponding to formula (III) is a novel compound.

Abstract: Allylbenzene is converted to indene by means of a tungsten-containing catalyst.

Abstract: 1,1,3,3-substituted hydroxyindanes of the formula ##STR1## wherein R.sup.1 is selected from the group of hydrogen, halogen and optionally substituted alkyl, cycloalkyl, aralkyl and aryl and the group ##STR2## wherein X is sulphur or the group ##STR3## R.sup.2 and R.sup.3 can be the same or different and are selected from the group of hydrogen, halogen and optionally substituted alkyl, cycloalkyl, aralkyl and aryl group, or, ifR.sup.2 and R.sup.3 are in the ortho position to each other, they may form a condensed carbocyclic 5-membered ring together with the carbon atoms of the benzene ring to which they are attached as substituents,R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are the same or different and are selected from the group of optionally substituted alkyl, cycloalkyl, aralkyl and aryl orR.sup.4 and R.sup.5 and/or R.sup.6 and R.sup.7 and/or R.sup.8 and R.sup.9 can form a cycloaliphatic ring together with the carbon atom to which they are attached as substituents orR.sup.6 and/or R.sup.

Abstract: Indene compounds of the formula ##STR1## wherein X represents a hydrogen atom, a halogen atom, a hydroxyl group or a methyl group, andy is 0 or an integer of 1 to 3,are produced by either heat-decomposing indene compounds of the formula ##STR2## wherein X and y are as defined, in the presence of an acid or alkaline catalyst; or heat-decomposing isopropenyl phenols of the formula ##STR3## wherein X and y are as defined,or oligomers or polymers thereof in the presence of an acid catalyst. 5-Hydroxy-1,1,3-trimethyl-2-indene corresponding to formula (III) is a novel compound.

Abstract: The present invention relates to novel compositions of matter and novel processes for preparing these compositions of matter. Moreover, there are provided novel methods by which certain of these novel compositions of matter are employed for pharmacologically useful purposes.

Abstract: An improved process is provided for the preparation of a certain class of hydroxyphenyl-indanol compounds by the cyclization of a phenol selected from the group consisting of an isopropenylphenol, oligomers thereof, and mixtures of any of said group in any combination and proportion, by dissolving said phenol in a stoichiometric excess of an organic acid selected from the group consisting of trifluoroacetic acid, trichloroacetic acid, difluoroacetic acid, dichloroacetic acid, fluoroacetic acid, chloroacetic acid, formic acid, and mixtures thereof at a temperature falling within a range of from about 0.degree. C. to about 90.degree. C. to form a solution; and maintaining said solution at a temperature falling within the above said range until the formation of said indanol is substantially complete.The dihydroxy compounds produced by the present method are useful in the preparation of epoxy, alkyd, and urethane resins in particular.

Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.

Abstract: Novel norbornenyl phenolics useful as antioxidants are defined by the following structural formula: ##STR1## where R.sup.1, R.sup.2, and R.sup.3 are individually selected from hydrogen and alkyl groups of 1 to 3 carbon atoms; R.sup.4 is selected from hydrogen, alkyl groups containing 1 to 12 carbon atoms, and substituted and unsubstituted alicyclic groups of 4 to 8 carbon atoms; R.sup.5 is selected from alkyl groups containing 1 to 6 carbon atoms, and substituted and unsubstituted alicyclic groups of 4 to 8 carbon atoms; R.sup.7 is selected from alkylene and alkenylene groups containing 1 to 8 carbon atoms; and R.sup.8 is selected from hydrogen, alkyl and alkenyl groups containing 1 to 8 carbon atoms.

Abstract: Compounds having the formula ##STR1## wherein ##STR2## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.

Abstract: The present invention relates to novel compounds of the general formula ##STR1## wherein R.sup.1 is --H or --CO--alk, wherein alk is lower alkyl of 1 to 5 carbon atoms; R.sup.2 is 1,1-dimethylheptyl or 1,2-dimethylheptyl, Q is --CH.sub.3 when A------B is a single bond, and Q is --CH.sub.2 OR.sup.4 when A------B is a double bond, and R.sup.4 is --H or --CO--alk where alk is lower alkyl of 1 to inclusive 5 carbon atoms.The invention relates both to the isomeric mixtures and to the individual isomers of the above compounds. Furthermore the invention relates to pharmaceutical compositions containing a compound defined above as active ingredient. The pharmaceutical compositions are of value as central nervous system depressants, as sedatives, as tranquilizers, as anticonvulsant agents, as effective agents against migraine, for the treatment of glaucoma, as antidiarrheal agents and as antiinflammatory agents.

Abstract: The invention concerns to new (isocamph-5-yl)-guaiacyl ethers of the formula ##STR1## wherein R is an isocamph-5-yl radical in the 6- or 4-position relative to the ethoxy group;a process for their preparation and their use for the preparation of 3-(isocamph-5-yl)-cyclohexanol which is an important constituent of sandal compound.

Abstract: Disclosed are tellurium (IV) compounds represented by the formula: ##STR1## wherein: D is a Lewis base function containing a group VA or VIA donor atom;Q represents the atoms necessary to complete a 5- or 6-membered ring, when taken together with C, D and Te, when m is 1 and represents the atoms linking C and D when m is greater than 1;R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkyl and aryl;X is an anion;n is 1 or 2; andm is an integer from 1 to 500.These compounds are useful in an image-forming combination comprising the described Te(IV) compound and a reducing agent. The image-forming combination is useful in a variety of materials, including a dry amplification element.

Abstract: A process for preparing 6-isobornyl-3,4-xylenol by condensing camphene and 3,4-dimethylphenol benzylether in an inert anhydrous organic solvent in the presence of a Friedel-Crafts catalyst at a temperature of around 0.degree. C., and the 6-isobornyl-3,4-xylenol benzylether thus obtained is debenzylated by hydrogenating in the presence of a solvent and a hydrogenation catalyst.

Abstract: The invention concerns new [isocamph-5-yl]-guaiacyl esters of the formula ##STR1## in which R represents an isocamph-5-yl radical located in the 2-position or 4-position relative to the OAc group and Ac represents a C.sub.1 -C.sub.4 -alkylsulphonyl or di-(C.sub.1 -C.sub.4 -alkyl)-phosphoryl radical; a process for their preparation and their use for the preparation of 3-[isocamph-5-yl]-cyclo-hexanol which is an important constituent of sandal compound.

Abstract: A novel method for producing hydroquinone and quinone derivatives by a regio- and stereo-specific coupling reaction of hydroquinone derivative having a terminal activated (poly)prenyl side chain with a prenyl derivative. This method can provide in good yield various hydroquinone and quinone derivatives having any prenyl length of the side chain.

Abstract: There is described a process for the production of 6-hydroxy-1,2,3,4-tetrahydronaphthalene of formula I, ##STR1## which comprises treatment of beta naphthol with an absorbant, removal of the absorbant and selective hydrogenation of the resulting beta naphthol, preferably in a solvent which is inert under the reaction conditions. There is also described a process for the production of a compound of formula I using a rhodium catalyst.

Abstract: A very efficient method with respect to the reaction velocity as well as selectivity is proposed for the preparation of .alpha.-tetralone by the liquid phase oxidation of tetralin with oxygen, in which a binary catalyst is employed which is composed of a compound of chromium or cobalt soluble in the reaction mixture and an N,N-dialkyl substituted carboxylic acid amide such as N,N-dimethylformamide, N,N-dimethylacetamide and the like.

Abstract: A process for the hydroxylation of phenols and phenol ethers in the nucleus with hydrogen peroxide wherein a phenol or a phenol ether is reacted at the start of the reaction with substantially anhydrous hydrogen peroxide and wherein the reaction is carried out in the presence of a strong acid.

Abstract: New terpenophenols of the general formula: ##STR1## wherein R is a 2-isobornyl, 5-camphyl or 2-norbornyl group of exo or endo configuration and in the ortho, meta or para position with respect to the OH group; R.sub.1, R.sub.2 may each be a hydrogen atom or halogen atom (Cl, Br, F,I) or a lower alkyl or lower alkoxy radical having a straight or branched chain of 1 to 4 carbon atoms or a nitro or cyano group.