Additional Ring Containing Patents (Class 568/807)
  • Publication number: 20150126779
    Abstract: This invention selectively synthesizes a cycloparaphenylene compound having 10, 11, or 13 benzene rings. The invention also synthesizes a cycloparaphenylene compound in which a functional group is introduced into a desired portion. By reacting specific raw materials using a specific reaction, a cyclic compound having 10, 11, or 13 bivalent aromatic hydrocarbon groups, bivalent heterocyclic groups, or derivative groups thereof can be selectively obtained as a pure substance.
    Type: Application
    Filed: March 7, 2013
    Publication date: May 7, 2015
    Inventors: Kenichiro Itami, Yasutomo Segawa, Haruka Omachi, Sanae Matsuura, Yusuke Nakanishi, Yuuki Ishii
  • Publication number: 20150025237
    Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 22, 2015
    Inventors: George Anthony Moniz, Annie Zhu Wilcoxen, Farid Benayoud, Jaemoon Lee, Huiming Zhang, Taro Terauchi, Ayumi Takemura, Yu Yoshida, Toshiaki Tanaka, Keiichi Sorimachi, Yoshimitsu Naoe, Yuji Kazuta
  • Publication number: 20150018560
    Abstract: The present invention relates to a process for preparing a diol of the formulae (Ia) or (Ib), or a mixture thereof, comprising the reaction of an epoxy alcohol of formulae (Va) or (Vb), or a mixture thereof, with alkali metal borohydride or earth alkaline borohydride, in particular sodium borohydride, and anhydrous aluminum(III) chloride. The invention also relates to processes and intermediates for preparing an epoxy alcohol of formulae (Va) or (Vb). The invention furthermore relates to processes for preparing cis-metconazole in which a diol of the formulae (Ia) or (Ib) is applied as a precursor.
    Type: Application
    Filed: February 7, 2013
    Publication date: January 15, 2015
    Applicant: BASf ARGO B.V. ARNHEM (NL). ZURICH-BRANCH
    Inventors: Thomas Zierke, Paul Kemper
  • Publication number: 20140356230
    Abstract: A synergistic microbicidal composition containing a phenolic compound selected from the class consisting of chlorinated phenols, monosubstituted phenols, fused bicyclic phenols, isopropyl methyl catechols, and monosubstituted catechols and an antimicrobial alcohol selected from the class of menthadiene alcohols and other antimicrobial alcohols.
    Type: Application
    Filed: December 5, 2012
    Publication date: December 4, 2014
    Applicant: ROHM AND HAAS COMPANY
    Inventors: Robert J. Cornmell, Megan A. Diehl, Stephen Golding, John R. Harp, Ian P. Stott, Katherine M. Thompson, Carol L. Truslow
  • Publication number: 20140165873
    Abstract: A compound of the formula wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are each independently selected from a member of the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkylaryl, straight-chain hydrocarbon, branched-chain hydrocarbon, halogen, and mixtures thereof; wherein X1, X2, X3, X4, and X5 are each independently selected from a member of the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkylaryl, alkoxyl, aryloxy, straight-chain hydrocarbon, branched-chain hydrocarbon, halogen, and mixtures thereof; and wherein the compound can optionally be a mixture of cis and trans isomers wherein only one of R1 to R10 is a non-hydrogen group.
    Type: Application
    Filed: December 18, 2012
    Publication date: June 19, 2014
    Applicant: XEROX CORPORATION
    Inventors: Naveen Chopra, Guerino G. Sacripante, Jordan H. Wosnick
  • Publication number: 20140135374
    Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: June 13, 2012
    Publication date: May 15, 2014
    Applicant: BIKAM PHARMACEUTICALS, INC.
    Inventor: David S. Garvey
  • Publication number: 20140066640
    Abstract: A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.
    Type: Application
    Filed: April 19, 2012
    Publication date: March 6, 2014
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: G.K. Surya Prakash, Parag V. Jog, Patrice T.D. Batamack, George A. Olah
  • Publication number: 20130225822
    Abstract: The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7?-amino-1,1?-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7?-amino-1,1?-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.
    Type: Application
    Filed: November 18, 2011
    Publication date: August 29, 2013
    Inventors: Qilin Zhou, Jianhua Xie, Xiaoyan Liu, Jianbo Xie, Lixin Wang
  • Publication number: 20130184470
    Abstract: Process for preparing 5-[1-(4-chlorophenyl)-methylene]-1-hydroxymethyl-2,2-dimethyl-cyclopentanol A process for preparing diols (Ia) and (Ib) by reacting an oxirane (II) with water and hydrogenating the resulting 5[1-(4-chlorophenyl)-meth-(E)-ylidene]-1-hydroxymethyl-2, 2-dimethyl-cyclopentanol (III) with hydrogen in the presence of a metal catalyst. Compounds (Ia), (Ib) and (III) are intermediates for synthesizing Metconazole.
    Type: Application
    Filed: September 28, 2011
    Publication date: July 18, 2013
    Inventor: Thomas Zierke
  • Publication number: 20130158276
    Abstract: Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.
    Type: Application
    Filed: June 17, 2011
    Publication date: June 20, 2013
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Taichiro Touge, Hideki Nara, Tomohiko Hakamada
  • Publication number: 20130053574
    Abstract: The invention relates to an asymmetric hydrogenation method for ketone compounds, comprising the step of: under hydrogen atmosphere, in the presence of an in situ catalyst derived from a chiral ligand and a ruthenium salt, adding a ketone compound and a base into a second solvent to carry out an asymmetric hydrogenation for the ketone compound. The invention can obtain a conversion of 100% and a highest asymmetric inducement effect of 99.7% for the ketone compound. The invention has the advantages including simple procedure, high conversion and selectivity, good atom economy and good prospect of industrial application.
    Type: Application
    Filed: April 16, 2012
    Publication date: February 28, 2013
    Applicant: NIPPON CHEMICAL INDUSTRIAL CO., LTD.
    Inventors: Wanbin Zhang, Delong Liu, Hui Guo, Yangang Liu
  • Publication number: 20120289674
    Abstract: A compound represented by a formula 1 shown below. In the formula 1, each of R1 and R2 independently represents a group selected from the group consisting of a hydrogen atom and substituents composed of C, H and/or X (wherein X represents a hetero atom), and each of Z1 and Z2 independently represents a group selected from the group consisting of aromatic substituents composed of C and H, aromatic substituents composed of C, H and X (wherein X represents a hetero atom), groups containing an aromatic ring and a double-bonded and/or triple-bonded conjugated structure composed of C and H, and groups containing an aromatic ring and a double-bonded and/or triple-bonded conjugated structure composed of C, H and/or X (wherein X represents a hetero atom).
    Type: Application
    Filed: January 28, 2011
    Publication date: November 15, 2012
    Applicants: Kanagawa University, Hitachi Chemical Company, Ltd.
    Inventors: Shigeaki Funyuu, Kenichi Ishitsuka, Hideo Nakako, Sentaro Okamoto
  • Patent number: 8283502
    Abstract: An autocatalytic process for the synthesis of chiral propargylic alcohols.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: October 9, 2012
    Assignee: Lonza Ltd.
    Inventors: Nicka Chinkov, Aleksander Warm, Erick Carreira
  • Patent number: 8227643
    Abstract: This invention relates to bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable salts and their use in the modulation of Sirtuin 1 (Sirt1) and there use in neuroprotection for subject suffering from neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, including Parkinson's plus diseases such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and dementia with Lewy bodies, and in the manufacture of medicaments for such Sirt1 modulation and neuroprotection.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: July 24, 2012
    Assignee: ProteoTech, Inc.
    Inventors: Alan D. Snow, Qubai Hu, Judy A. Cam
  • Publication number: 20120182516
    Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Application
    Filed: August 30, 2010
    Publication date: July 19, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Andreas Taugerbeck, Achim Goetz
  • Publication number: 20120172337
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 5, 2012
    Applicant: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20120142934
    Abstract: A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.
    Type: Application
    Filed: March 10, 2011
    Publication date: June 7, 2012
    Inventors: Chien-Hong CHENG, Jaganathan Karthikeyan, Pang-Chi Huang
  • Patent number: 8168835
    Abstract: A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: May 1, 2012
    Assignee: National Tsing Hua University
    Inventors: Biing-Jiun Uang, Ping-Yu Wu, Hsyueh-Liang Wu
  • Publication number: 20120065430
    Abstract: Polarized unsaturated functional groups is directly reduced by using metal amidoborane or derivatives thereof through double hydrogen transfer process. Over 99% conversion of reagents and high isolated yield of products can be achieved after reaction.
    Type: Application
    Filed: November 23, 2010
    Publication date: March 15, 2012
    Inventors: Ping Chen, Weiliang Xu, Zhitao Xiong, Guotao Wu
  • Publication number: 20120029237
    Abstract: An autocatalytic process for the synthesis of chiral propargylic alcohols.
    Type: Application
    Filed: April 9, 2010
    Publication date: February 2, 2012
    Inventors: Nicka Chinkov, Aleksander Warm, Erick Carreira
  • Patent number: 8101804
    Abstract: A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: January 24, 2012
    Assignee: Clariant Specialty Fine Chemicals (France)
    Inventors: Alain Schouteeten, Sébastien Jus, Jean-Claude Vallejos
  • Publication number: 20110313203
    Abstract: The present invention relates to a process for purifying crude polymethylol which comprises polymethylol of the formula (I) (HOCH2)2—C—R2 ??(I) in which each R is independently a further methylol group or an alkyl group having 1 to 22 carbon atoms or an aryl or aralkyl group having 6 to 22 carbon atoms, and also hydroxy acid of the formula (IV) in which each R is independently as defined above, which comprises performing the purification in a distillation column, the bottom of the distillation column being connected to an evaporator with a short residence time. The present invention further relates to a composition comprising polymethylol and 1 to 10 000 ppm by weight of an ester of polymethylol and of a hydroxy acid and to the use thereof.
    Type: Application
    Filed: December 7, 2009
    Publication date: December 22, 2011
    Applicant: BASF SE
    Inventors: Tilman Sirch, Michael Steiniger, Steffen Maas, Stefan Rittinger
  • Publication number: 20110295042
    Abstract: A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 1, 2011
    Inventors: Biing-Jiun UANG, Ping-Yu Wu, Hsyueh-Liang Wu
  • Patent number: 8049042
    Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: November 1, 2011
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
  • Publication number: 20110251390
    Abstract: Chiral amino alcohol and amino phosphine compounds are provided herein, which compounds are useful for asymmetric synthesis.
    Type: Application
    Filed: October 2, 2009
    Publication date: October 13, 2011
    Inventors: Daniel L. Comins, Sonja S. Capracotta
  • Patent number: 7968727
    Abstract: 4-bromomethyl-2?-formylbiphenyl and 4-bromomethyl-2?-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2?-cyanobiphenyl or 4?-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: June 28, 2011
    Assignee: Lek Pharmaceuticals, D.D.
    Inventors: Anton Copar, Ljubomir Antoncic, Matej Antoncic
  • Publication number: 20110124924
    Abstract: A method for the preparation of cyclopropyl carbinols by cyclopropanation of unsaturated alcoholates, utilising a reagent system selected from (A) magnesium metal and dibromomethane, and (B) dibromomethane and a tertiary Grignard reagent, the reaction being carried out in the presence of an ether solvent. The process is useful, for example, for the preparation of ingredients for the flavour and fragrance industry.
    Type: Application
    Filed: August 19, 2008
    Publication date: May 26, 2011
    Applicant: GIVAUDAN SA
    Inventor: Fridtjof Schroder
  • Publication number: 20110077393
    Abstract: Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of chemical synthesis processes. Accordingly, the utility of the methods disclosed herein includes the ability to automate chemical synthesis and purification of the resulting products.
    Type: Application
    Filed: August 9, 2010
    Publication date: March 31, 2011
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION
    Inventors: Gerald B. Hammond, Bo Xu
  • Patent number: 7737127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: June 15, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • Patent number: 7714170
    Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, use in the reduction of A? peptide in vivo, use in modulating APP processing, and use in modulating the activity of APP secretase.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: May 11, 2010
    Assignee: Proteotech, Inc.
    Inventors: Alan D. Snow, Qubai Hu, Judy A. Cam
  • Patent number: 7700657
    Abstract: Novel vitamin D analogs, markedly active in the fields of cell proliferation and differentiation, are selected from among (4E,6E)-7-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl}-3-ethylnona-4,6-dien-3-ol, (E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, (3E,5E)-6-[3-(3,4-bis-hydroxymethylbenzyloxy)-phenyl]-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, (E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)ethyl]phenyl}-1,1,1-trifluoro-2-trifluoromethyloct-5-en-3-yn-2-ol, and (3E,5E)-6-{3-[2-(3,4-bis-hydroxymethylphenyl)-ethyl]phenyl-1,1,1-trifluoro-2-trifluoromethylocta-3,5-dien-2-ol, and the geometric isomers thereof and these compounds in which one or more of the hydroxyl functions are protected by a protective group —(C?O)—R, in which R is a linear or branched alkyl radical having from 1 to 6 carbon atoms, an aryl radical having from 6 to 10 carbon atoms, or an aralkyl radical having from 7 to 11 carbon atoms, the aryl radical or the aralkyl radical optional
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: April 20, 2010
    Assignee: Galderma Research & Development
    Inventor: Jean-Michel Bernardon
  • Publication number: 20100004483
    Abstract: A subject-matter of the present invention is a novel process for the synthesis of (E)-stilbene derivatives targeted at obtaining in particular resveratrol and piceatannol.
    Type: Application
    Filed: July 25, 2007
    Publication date: January 7, 2010
    Applicant: CLARIANT SPECIALTY FINE CHEMICALS (FRANCE)
    Inventors: Alain Schouteeten, Sébastien Jus, Jean-Claude Vallejos
  • Publication number: 20090318521
    Abstract: 4-bromomethyl-2?-formylbiphenyl and 4-bromomethyl-2?-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2?-cyanobiphenyl or 4?-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
    Type: Application
    Filed: March 30, 2006
    Publication date: December 24, 2009
    Applicant: LEK PHARMACEUTICALS D.D.
    Inventors: Anton Copar, Ljubomic Antoncic, Matej Antoncic
  • Publication number: 20090312558
    Abstract: The present invention relates to an efficient process for preparing an arylcyclopropanecarbonitrile, which involves the use of sulfolane as a solvent.
    Type: Application
    Filed: June 26, 2008
    Publication date: December 17, 2009
    Applicant: Reliance Life Sciences Pvt. Ltd.
    Inventors: Sandeep Pandurang Bhujbal, Venkata Ramana Kondepati, Rajesh Rao, Jayaraman Venkat Raman
  • Patent number: 7601876
    Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: October 13, 2009
    Assignee: Proteotech, Inc.
    Inventors: Alan D. Snow, Beth P. Nguyen, Gerardo M. Castillo, Virginia J. Sanders, Thomas P. Lake, Lesley Larsen, Rex T. Weavers, Stephen D. Lorimer, David S. Larsen, David L. Coffen, Charlotte Coffen, legal representative
  • Patent number: 7586015
    Abstract: A process is used for the preparation of 1,3,2-oxazaborolidine compounds. This process prepares compounds of formula (I) or (IA): in which: R1 is an alkyl or an aryl; and R2, R3, R4 and R5 are especially a hydrogen atom or an alkyl, wherein the following are reacted in two steps: a) a boric precursor compound with an acetal compound to give a boronate compound; and b) the boronate compound with an amino alcohol compound. This process avoids by-products and exhibits a very good stereospecificity.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 8, 2009
    Assignee: Zach System
    Inventors: Alain Burgos, Stëphane Frein
  • Patent number: 7560597
    Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2?,4?-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof: wherein: n is independently 1, 2, 3, or 4; W is independently —C(?O)—, —CH(OH)—, or —C(?NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(?O)—RE2, —C(?O)—O—RE3, —C(?O)—O—S(?O)2ORE4, —C(?O)—(CH2)n—C(?O)ORE5, —C(?O)—(CH2)n—NRNE1RNE2, —C(?O)—(CH2)n—NRNE3—C(?O)RE6, —C(?O)—(CH2)n—C(?O)—NRNE4RNE5, or —P(?O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: July 14, 2009
    Assignee: The University Court of the University of Aberdeen
    Inventors: Iain Robert Greig, Robert Jurgen van 't Hof, Stuart Hamilton Ralston
  • Publication number: 20080312186
    Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.
    Type: Application
    Filed: August 19, 2008
    Publication date: December 18, 2008
    Applicant: The University Court of the University of Aberdeen
    Inventors: Stuart H. RALSTON, Iain R. GREIG, Aymen I. I. MOHAMED, Robert J. VAN 'T HOF
  • Patent number: 7465838
    Abstract: The present invention relates to a method for the preparation of C2-symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R1 and R2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of ?-(aryl or heteroaryl)-?-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C2-symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: December 16, 2008
    Assignee: Ciba Specialty Chemical Corp.
    Inventor: Ulrich Berens
  • Publication number: 20080221220
    Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2?,4?-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to compounds selected from compounds of the following formula and pharmaceutically acceptable salts, solvates, and hydrates thereof: wherein: n is independently 1, 2, 3, or 4; W is independently —C(?O)—, —CH(OH)—, or —C(?NOROX)—; ROX is independently —H or C1-3alkyl; J is independently: —H, —RE1, —C(?O)—RE2, —C(?O)—O—RE3, —C(?O)—O—S(?O)2ORE4, —C(?O)—(CH2)n—C(?O)ORE5, —C(?O)—(CH2)n—NRNE1RNE2, —C(?O)—(CH2)n—NRNE3—C(?O)RE6, —C(?O)—(CH2)n—C(?O)—NRNE4RNE5, or —P(?O)(ORE7)(ORE8); wherein each of RE1, RE2, RE3, RE4, RE5, RE6, and RE7 is independently: —H, C1-3alkyl, -Ph, or —CH2-Ph.
    Type: Application
    Filed: March 6, 2008
    Publication date: September 11, 2008
    Inventors: Iain Robert Greig, Robert Jurgen van 't Hof, Stuart Hamilton Ralston
  • Publication number: 20080206490
    Abstract: The present invention relates to cyclobutane and spiro[3.3]heptane compounds, to a process for the preparation thereof, to the use thereof as components in liquid-crystalline media, and to electro-optical display elements which contain these liquid-crystalline media.
    Type: Application
    Filed: August 16, 2006
    Publication date: August 28, 2008
    Inventors: Volker Reiffenrath, Matthias Bremer, Melanie Klasen-Memmer
  • Publication number: 20080160417
    Abstract: Provided is a polymer composition containing an oxocarbon and a polymer, further, a polymer composition that the oxocarbon are expressed by formula (1).
    Type: Application
    Filed: January 10, 2006
    Publication date: July 3, 2008
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Ken Yoshimura
  • Patent number: 7312249
    Abstract: Novel biaromatic vitamin D analogues have the general formula (I): and are suited for a wide variety of pharmaceutical applications, whether in human or veterinary medicine, and also for cosmetic applications.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: December 25, 2007
    Assignee: Galderma Research & Development
    Inventors: Thibaud Biadatti, Etienne Thoreau, Johannes Voegel, Andre Jomard
  • Patent number: 7166337
    Abstract: The present invention relates to liquid-crystal mixtures having specific resistance values, comprising acidic compounds. The present invention furthermore relates to liquid-crystal displays containing these liquid-crystal mixtures. The invention furthermore relates to compounds of the formula I, in which the parameters are as defined in the text, to their preparation, and to their use for achieving certain specific resistance values in liquid-crystal mixtures. The application also relates to a method of adjusting the specific resistance of liquid-crystal mixtures using acidic compounds.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: January 23, 2007
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Darius, Volker Reiffenrath, Kazuaki Tarumi, Bernhard Rieger, Michael Heckmeier, Marcus Reuter, Peer Kirsch
  • Patent number: 7132294
    Abstract: The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two pendant and terminal unsaturated groups, each being functionalized with at least one halogen substituted alcohol or phenol functional group. The compound of the invention preferably has one of the following general formulae: wherein A is a core moiety; B is a pendant and terminal unsaturated group; q is at least 1; r is at least 2; X is a linking group; and n is an integer designating the number of repeating units from 1 to 3, with the proviso that, if n is greater than 1, then the B groups differ from each other in at least two of the repeating units. The device is used to detect the molecules of a hydrogen bond accepting vapor such as an organophosphonate or nitroaromatic vapor.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: November 7, 2006
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Eric J. Houser, Robert Andrew McGill
  • Patent number: 6924400
    Abstract: The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I): and also to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: August 2, 2005
    Assignee: Galderma Research & Development, SNC
    Inventors: Jean-Michel Bernardon, Thibaud Biadatti
  • Patent number: 6831106
    Abstract: The present invention relates to novel triaromatic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, in carcinology and in the field of autoimmune diseases and that of organ or tissue transplants in particular), or alternatively in cosmetic compositions.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: December 14, 2004
    Assignee: Galderma Research & Development, S.N.C.
    Inventors: Jean-Michel Bernardon, Thibaud Biadatti
  • Patent number: 6828439
    Abstract: Disclosed are novel compounds, compositions, and methods that are particularly useful in photodynamic therapy. In particular, the inventive compounds, compositions, and methods relate to the formation of cytotoxic radical species in the presence of light. Significantly, the compounds, compositions, and methods of the present invention do not require the presence of oxygen in the photodynamic therapy and, as such, rely on a unimolecular mechanism for producing the radicals. The inventive compounds, compositions, and methods can be used, for example, in the treatment of cancers as well as infections caused by microorganisms such as protozoa, fungi, bacteria, and viruses.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: December 7, 2004
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: Jeffrey M. Zaleski, Diwan Singh Rawat
  • Publication number: 20040199028
    Abstract: A antimicrobial compound, compositions containing the same, and method of using the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated hydroxyalkyl-substituted phenol compounds.
    Type: Application
    Filed: April 19, 2004
    Publication date: October 7, 2004
    Inventors: D. Scott Harper, Robert A. Coburn, Andre Soshinsky, Marianne D. Huntley
  • Patent number: 6765117
    Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF1-type compounds.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: July 20, 2004
    Assignee: United Therapeutic Corporation
    Inventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski