Polycyclo Ring System Patents (Class 568/808)
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Publication number: 20110155944Abstract: An aromatic ring-containing compound for a resist underlayer and a resist underlayer composition, the aromatic ring-containing compound being represented by the following Chemical Formula 1: wherein, in Chemical Formula 1, R1 to R6 are each independently a substituted or unsubstituted C1 to C10 alkyl group, a substituted or unsubstituted C5 to C20 aromatic ring group, a substituted or unsubstituted C3 to C20 cycloalkyl group, a substituted or unsubstituted C3 to C20 cycloalkenyl group, a substituted or unsubstituted C2 to C20 heteroaryl group, or a substituted or unsubstituted C2 to C20 heterocycloalkyl group, X1 to X6 are each independently hydrogen, a hydroxy group (—OH), a substituted or unsubstituted alkyl amine group, a substituted or unsubstituted alkoxy group, or an amino group (—NH2), n1 to n6 are each independently 0 or 1, and 1?n1+n2+n3+n4+n5+n6?6.Type: ApplicationFiled: December 29, 2010Publication date: June 30, 2011Inventors: Sung-Wook Cho, Hwan-Sung Cheon, Min-Soo Kim, Seung-Bae Oh, Jee-Yun Song
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Publication number: 20110077394Abstract: Compounds of Formula (1) are disclosed. Cb is a carbocyclic or heterocyclic group having an atom within the cyclic structure selected from C, N, Si, and Cr and singly bound to A. A is CR, COR, CSR, CNR2, CCN, CCONR2, CNO2, CNNAr, CX?, or N. Cr is a chromophore having a substantially planar cyclic structure. The compounds function as nanometer-scale rotary molecular motors powered and controlled by light energy. The design of the molecular motor devices is flexible so that the rotary direction, drive light wavelength, and other physical characteristics can be varied. The compounds can be chemically functionalized to allow it to be integrated into or attached to a variety of structures. The device can be used in applications where mechanical power, positional control, and information encoding are to be generated at the size scale of individual molecules.Type: ApplicationFiled: June 24, 2004Publication date: March 31, 2011Inventors: Thomas W. Bell, Joseph I. Cline, Christine R. Cremo, Stephen L. Gillett, John H. Frederick
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Patent number: 7892702Abstract: Photosensitizing dyes are often used in conjunction with a photoacid generator in holographic recording media. Conventional photosensitizing dyes typically are limited by having an appreciable absorption of light when used in a sufficient concentration, such that the intensity of light decreases significantly with penetration into a recording medium. The present invention discloses a number of new 5-alkynyl substituted napthacene photosensitizing dyes that have low extinction coefficients coupled with good sensitizing properties, such that the problems associated with the photosensitizing dyes absorbing light are significantly reduced.Type: GrantFiled: February 21, 2008Date of Patent: February 22, 2011Assignee: ForceTEC Co., Ltd.Inventors: David A. Waldman, Eric S. Kolb, Kirk D. Hutchinson, Richard A. Minns
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Publication number: 20110009646Abstract: There are provided a novel ruthenium-diamine complex, and methods for selectively producing an optically active alcohol and an optically active amine, which are important as precursors for the synthesis of medicinal drugs and functional materials, using the ruthenium-diamine complex as a catalyst. A novel ruthenium-diamine complex prepared by introducing a trisubstituted silyl group into an aromatic compound (arene) moiety that is coordinated with a ruthenium complex having an optically active diamine as a ligand, a catalyst for asymmetric reduction formed from the ruthenium-diamine complex, and a method for producing an optically active alcohol or an optically active amine using the catalyst.Type: ApplicationFiled: July 13, 2010Publication date: January 13, 2011Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Taichiro Touge, Hideki Nara
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Patent number: 7863488Abstract: A method comprising reducing an acenequinone to form an acenepolyhydrodiol by exposing the acenequinone to a reducing environment comprising an alkoxyaluminate.Type: GrantFiled: February 8, 2010Date of Patent: January 4, 2011Assignees: Alcatel-Lucent USA Inc., Columbia UniversityInventor: Xiaoliu Chi
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Publication number: 20100324291Abstract: Methods for the preparation of 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and salts thereof are described.Type: ApplicationFiled: June 22, 2010Publication date: December 23, 2010Applicant: H. LUNDBECK A/SInventors: Heidi Lopez de Diego, Ole Nielsen, Lone Munch Ringgard, Henrik Svane, Allan Carsten Dahl, Mark Howells, Benny Bang-Andersen, Lars Ole Lyngsø, Sherry Lynn Collier
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Publication number: 20100297250Abstract: 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.Type: ApplicationFiled: November 21, 2008Publication date: November 25, 2010Applicant: University of Georgia Research Foundation, Inc.Inventors: Geert-Jan Boons, Jun Guo, Xinghai Ning, Margaretha Wolfert
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Publication number: 20100240634Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.Type: ApplicationFiled: October 9, 2009Publication date: September 23, 2010Applicant: JAPAN TOBACCO INC.Inventors: Takahisa Motomura, Hironobu Nagamori, Koichi Suzawa, Hirotsugu Ito, Toru Morita, Satoru Kobayashi, Hisashi Shinkai
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Publication number: 20100210854Abstract: Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.Type: ApplicationFiled: February 19, 2010Publication date: August 19, 2010Inventors: Vladimir V. Popik, Andrei A. Poloukhtine
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Publication number: 20100197976Abstract: Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group 8 transition metal compound a chiral phosphine and a chiral diamine of formula (I) in which R1, R2, R3 and R4 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, an aryl group or a urethane or sulphonyl group and R5, R6, R7 and R8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R1, R2, R3 and R4 is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.Type: ApplicationFiled: January 29, 2010Publication date: August 5, 2010Applicant: Johnson Matthey PLCInventors: William Patrick Hems, Gabriela Alexandra Grasa
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Publication number: 20100157202Abstract: A polymer compound which is useful as a light emitting material and a charge transporting material and excellent in electron injection property, comprising as a partial structure therein a structure of the following formula (a) is provided: (wherein, a ring A and a ring B represent each independently an aromatic ring or a non-aromatic ring, and at least one of the ring A and the ring B is an aromatic ring. A ring C represents an aromatic ring. Z1 represents an atom selected from a carbon atom, oxygen atom, sulfur atom, nitrogen atom, silicon atom, boron atom, phosphorus atom and selenium atom or a group containing the atom, and Z2 to Z6 represent each independently an atom selected from a carbon atom, silicon atom, nitrogen atom and boron atom or a group containing the atom.).Type: ApplicationFiled: November 9, 2006Publication date: June 24, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Shigeya Kobayashi, Satoshi Kobayashi
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Publication number: 20100144086Abstract: A method comprising reducing an acenequinone to form an acenepolyhydrodiol by exposing the acenequinone to a reducing environment comprising an alkoxyaluminate.Type: ApplicationFiled: February 8, 2010Publication date: June 10, 2010Applicants: Lucent Technologies Inc., Columbia UniversityInventor: Xiaoliu Chi
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Publication number: 20100087646Abstract: [Problem] To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. [Means for Solving Problems] The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R1 represents alkyl, alkenyl, etc.; R2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m+ represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).Type: ApplicationFiled: January 28, 2008Publication date: April 8, 2010Applicant: WAKO PURE CHEMICAL INDUSTRIES, LTD.Inventors: Norio Miyaura, Yasunori Yamamoto
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Publication number: 20100081849Abstract: The invention provides a reaction system comprising: a first reaction promoter capable of converting a first substrate into a first substance; and a plurality of microcapsules, each of said microcapsules comprising a second reaction promoter encapsulated within an encapsulant, said second reaction promoter being capable of converting a second substrate into a second substance. The second substrate is capable of passing through the encapsulant to contact the second reaction promoter and the second substance is capable of passing out of the microcapsules through the encapsulant.Type: ApplicationFiled: August 23, 2007Publication date: April 1, 2010Inventors: Anthony Frederick Masters, Alessandro Fois, Thomas Maschmeyer
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Publication number: 20100056819Abstract: The present invention provides a process for producing nano graphene platelets (NGPs) that are both dispersible and electrically conducting. The process comprises: (a) preparing a pristine NGP material from a graphitic material; and (b) subjecting the pristine NGP material to an oxidation treatment to obtain the dispersible NGP material, wherein the NGP material has an oxygen content no greater than 25% by weight. Conductive NGPs can find applications in transparent electrodes for solar cells or flat panel displays, additives for battery and supercapacitor electrodes, conductive nanocomposite for electromagnetic wave interference (EMI) shielding and static charge dissipation, etc.Type: ApplicationFiled: September 3, 2008Publication date: March 4, 2010Inventors: Bor Z. Jang, Aruna Zhamu
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Publication number: 20090309076Abstract: A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent Q attached thereto, each Q independently being —N3, —CN, —COOR?, —CCR?, —C(R?)C(R?)R?, —OCOR?, —OCOOR?, —SR?, —OSO2R??, and/or —CON(R?)R?, wherein each R? is hydrogen, an unsubstituted or substituted alkyl group having from 1 to 18 carbon atoms; an unsubstituted or substituted aryl group, an unsubstituted or substituted alkene or alkyne group having from 2 to 18 carbon atoms, wherein the substituents are halo or hydroxyl and R?? is —CF3 or a perfluorinated alkyl group having from 2 to 18 carbon atoms The number, locations and nature of the constituents Q are dependent upon the structure of the photochromic compound.Type: ApplicationFiled: December 5, 2008Publication date: December 17, 2009Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Darrin R. Dabideen, Anil Kumar, Terry A. Kellar, II
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Publication number: 20090226634Abstract: Methods for synthesizing 1,4-(ketone or ketal) bridged and/or 5,14-(ketone or ketal) bridged hydropentacenes useful as soluble precursors for formation of pentacene or substituted (e.g., halo) pentacenes; precursor compounds formed thereby; methods for preparing form the precursor compounds conductive thin films comprising pentacene or a substituted pentacene, and articles including such thin films are described. Also described are tetracene and anthracene derivatives which should also be useful in the formation of conductive thin films, among other uses.Type: ApplicationFiled: March 2, 2009Publication date: September 10, 2009Applicant: ACADEMIA SINICAInventors: Tahsin J. CHOW, Chung-Chih WU, Ta-Hsien CHUANG, Hsing-Hung HSIEH, Hsin-Hui HUANG
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Patent number: 7586015Abstract: A process is used for the preparation of 1,3,2-oxazaborolidine compounds. This process prepares compounds of formula (I) or (IA): in which: R1 is an alkyl or an aryl; and R2, R3, R4 and R5 are especially a hydrogen atom or an alkyl, wherein the following are reacted in two steps: a) a boric precursor compound with an acetal compound to give a boronate compound; and b) the boronate compound with an amino alcohol compound. This process avoids by-products and exhibits a very good stereospecificity.Type: GrantFiled: January 25, 2007Date of Patent: September 8, 2009Assignee: Zach SystemInventors: Alain Burgos, Stëphane Frein
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Publication number: 20090105241Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (“ADHD”), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.Type: ApplicationFiled: December 12, 2008Publication date: April 23, 2009Applicant: Cephalon FranceInventors: Brigitte Lesur, Christophe Yue, Sophie Chasset, Olivier Renault
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Publication number: 20090098072Abstract: The invention relates to the use of compounds of formula (X—Ar—Y), in which X and Y respectively are selected independently of one another from the groups H, C-1-8 alkyl and groups as per formulae (Ia), (Ib) or (Ic), together with other groups that are defined as cited in the description, as antioxidants. The invention also relates to corresponding novel compounds and preparations and to corresponding production methods for said compounds and preparations.Type: ApplicationFiled: March 26, 2007Publication date: April 16, 2009Inventors: Thomas Rudolph, Herwig Buchholz
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Publication number: 20090042105Abstract: Photosensitizing dyes are often used in conjunction with a photoacid generator in holographic recording media. Conventional photosensitizing dyes typically are limited by having an appreciable absorption of light when used in a sufficient concentration, such that the intensity of light decreases significantly with penetration into a recording medium. The present invention discloses a number of new 5-alkynyl substituted napthacene photosensitizing dyes that have low extinction coefficients coupled with good sensitizing properties, such that the problems associated with the photosensitizing dyes absorbing light are significantly reduced.Type: ApplicationFiled: February 21, 2008Publication date: February 12, 2009Applicant: DCE Aprilis, Inc.Inventors: David A. Waldman, Eric S. Kolb, Kirk D. Hutchinson, Richard A. Minns
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Patent number: 7465838Abstract: The present invention relates to a method for the preparation of C2-symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R1 and R2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of ?-(aryl or heteroaryl)-?-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C2-symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.Type: GrantFiled: September 23, 2003Date of Patent: December 16, 2008Assignee: Ciba Specialty Chemical Corp.Inventor: Ulrich Berens
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Publication number: 20080242892Abstract: A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.Type: ApplicationFiled: June 13, 2008Publication date: October 2, 2008Applicant: APICORE, LLCInventors: Satyam Nampalli, Brijesh Patel, Peter Xavier Tharial, Ravishanker Kovi
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Publication number: 20080139848Abstract: A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.Type: ApplicationFiled: December 11, 2006Publication date: June 12, 2008Applicant: Apicore, LLCInventors: Satyam S. Nampalli, Brijesh Patel, Peter Xavier Tharial, Ravishanker Kovi
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Publication number: 20080090026Abstract: The present invention relates to a liquid-crystal display of the PSA (polymer sustained alignment) type, and to novel liquid-crystal media and novel polymerizable compounds for use in PSA displays.Type: ApplicationFiled: October 11, 2007Publication date: April 17, 2008Inventors: Georg Bernatz, Andreas Taugerbeck
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Patent number: 7132294Abstract: The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two pendant and terminal unsaturated groups, each being functionalized with at least one halogen substituted alcohol or phenol functional group. The compound of the invention preferably has one of the following general formulae: wherein A is a core moiety; B is a pendant and terminal unsaturated group; q is at least 1; r is at least 2; X is a linking group; and n is an integer designating the number of repeating units from 1 to 3, with the proviso that, if n is greater than 1, then the B groups differ from each other in at least two of the repeating units. The device is used to detect the molecules of a hydrogen bond accepting vapor such as an organophosphonate or nitroaromatic vapor.Type: GrantFiled: February 25, 2002Date of Patent: November 7, 2006Assignee: The United States of America as represented by the Secretary of the NavyInventors: Eric J. Houser, Robert Andrew McGill
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Patent number: 7087798Abstract: A spirofluorenol such as 3?,9?-dimethoxy-5?-hydroxyspiro[(1H-cyclopent[d,e,f]phenanthrene)-1,7?-benzo[c]fluorene] is produced by protecting a hydroxyl group bonded to a particular fluorenone compound such as 3,9-dimethoxy-5-hydroxybenzo[c]fluorene-7-one with “a substituted silyl group in which the sum of carbon atoms of substituents bonded to a silicon atom is 5 to 12”, such as a t-butyldimethylsilyl group, then, reacting the fluorenone compound with a particular organometal compound such as 1-lithiophenanthrene so as to be transformed into a spiro form and, then, removing the protection therefrom. This method makes it possible to efficiently produce the spirofluorenol which is useful as a starting material for producing photochromic compounds.Type: GrantFiled: December 13, 2002Date of Patent: August 8, 2006Assignee: Tokuyama CorporationInventors: Hirohumi Shiigi, Noriyuki Fukada, Kenji Tanaka, Masao Yamaguchi
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Patent number: 6924400Abstract: The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I): and also to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.Type: GrantFiled: December 10, 2002Date of Patent: August 2, 2005Assignee: Galderma Research & Development, SNCInventors: Jean-Michel Bernardon, Thibaud Biadatti
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Patent number: 6787676Abstract: Non-chiral and, in particular, optically active alcohols are prepared from a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine in an advantageous manner by using a catalyst that contains both a support-bonded Ru(II) complex bisphosphine ligand and a diamine ligand.Type: GrantFiled: February 4, 2002Date of Patent: September 7, 2004Assignee: Studiengesellschaft Kohle mbHInventor: Dieter Arlt
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Patent number: 6727392Abstract: A process for preparing a compound of the formula useful as a non-steroidal glucocorticoid receptor modulator.Type: GrantFiled: October 15, 2002Date of Patent: April 27, 2004Assignees: Pfizer Inc., Pfizer Products Inc.Inventors: Jerry A. Murry, Timothy D. White
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Patent number: 6700025Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: January 5, 2001Date of Patent: March 2, 2004Assignee: United Therapeutics CorporationInventors: Robert M. Moriarty, Hitesh Batra
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Patent number: 6610889Abstract: Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal complex of a ligand of formula I, as defined further herein.Type: GrantFiled: October 31, 2001Date of Patent: August 26, 2003Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Barry M. Trost, Hisanaka Ito
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Publication number: 20030135053Abstract: The invention relates to novel bicyclic aromatic compounds which have the general formula (I): 1Type: ApplicationFiled: January 2, 2003Publication date: July 17, 2003Inventor: Jean-Michel Bernardon
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Patent number: 6586613Abstract: Substituted tetrahydro-naphthalenes and analogous compounds are prepared by reducing or condensing appropriate functional substituents in substituted tetrahydro-naphthalenes and analogous compounds by customary methods and converting functional groups in this manner into the desired groups. The compounds according to the invention are suitable for use as active compounds in pharmaceuticals, in particular in pharmaceuticals for treating arteriosclerosis and also dyslipidaemias.Type: GrantFiled: March 17, 2000Date of Patent: July 1, 2003Assignee: Bayer AktiengellschaftInventors: Arndt Brandes, Michael Lögers, Jürgen Stoltefuss, Gunter Schmidt, Klaus-Dieter Bremm, Hilmar Bischoff, Delf Schmidt, Stefan Antons, Holger Paulsen, Stephan Nicholas Müller, Paul Naab, Carsten Schmeck
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Patent number: 6566537Abstract: The invention relates to a process for the enantioselective preparation of tolterodine and analogues and salts thereof comprises the steps of: a) enantioselectively reducing the carbonyl function in a compound of formula (II): wherein R1, R2 and R3 independently of each other are hydrogen, methyl, methoxy, hydroxy, hydroxymethyl, carbamoyl, sulphamoyl or halogen, to form an enantiomerically enriched compound of formula (IIIa) or (IIIb): wherein R1, R2 and R3 are as defined above; b) subjecting the compound of formula (IIIa) or (IIb) to a sigmatropic rearrangement to form a corresponding enantiomerically enriched compound of formula (IVa) or (IVb): wherein R1, R2 and R3 are as defined above; c) subjecting the compound of formula (IVa) or (IVb) to a Baeyer-Villiger oxidation to form a corresponding enantiomerically enriched compound of the general formula (Va) or (Vb): wherein R1, R2 and R3 are as defined above; d) converting the compouType: GrantFiled: July 31, 2001Date of Patent: May 20, 2003Assignee: Pharmacia ABInventors: Pher G. Andersson, Christian Hedberg
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Patent number: 6521755Abstract: This invention provides a process to prepare 10,11-(optionally substituted)methanodibenzosuberane derivatives. The invention also provides an intermediate in this process.Type: GrantFiled: November 15, 2001Date of Patent: February 18, 2003Assignee: Eli Lilly and CompanyInventors: Bret Eugene Huff, Michael Edward LeTourneau, Thomas Michael Wilson, Julie Kay Bush, Susan Marie Reutzel-Edens
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Patent number: 6465700Abstract: Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.Type: GrantFiled: August 3, 1998Date of Patent: October 15, 2002Assignee: Boulder Scientific CompanyInventors: Jeffrey M. Sullivan, Hamlin H. Barnes
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Patent number: 6448412Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.Type: GrantFiled: October 30, 2000Date of Patent: September 10, 2002Assignee: Sphere Biosystems, Inc.Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
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Patent number: 6399785Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the Cn fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.Type: GrantFiled: October 30, 2000Date of Patent: June 4, 2002Assignee: C-Sixty, Inc.Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
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Patent number: 6342642Abstract: The present invention provides novel 1,4-diaryl-2-fluoro-1-buten-3-ol compounds of the structural formula I a method for the preparation of those formula I compounds, and the use of those formula I compounds in the preparation of 1,4-diaryl-2-fluoro-1,3-butadiene compounds of formula II and 1,4-diaryl-2-fluoro-2-butene compounds of formula IIIType: GrantFiled: August 13, 2001Date of Patent: January 29, 2002Assignee: BASF AktiengesellschaftInventors: Yulin Hu, David Allen Hunt
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Patent number: 6333435Abstract: A process of synthesizing a compound of the formula 1: is disclosed, which comprises reacting a compound of the formula 2: with diphenylphosphine in the presence of an amine base and a nickel catalyst to produce a compound of formula 1.Type: GrantFiled: May 18, 1995Date of Patent: December 25, 2001Assignee: Merck & Co., Inc.Inventors: Dongwei Cai, David L. Hughes, Sylvain Levac, Thomas R. Verhoeven
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Patent number: 6323173Abstract: The compounds of the formula wherein the symbols R1, R2, R3 and R4 represent, independently of one another, a hydrogen atom or a linear or branched, saturated or unsaturated C1 to C3 lower alkyl radical, are advantageous as perfuming ingredients for the preparation of perfuming compositions and perfumed articles, to which they impart odoriferous notes of the lily of the valley type.Type: GrantFiled: January 6, 2000Date of Patent: November 27, 2001Assignee: Firmenich SAInventors: Beat Winter, Philippe Schneider
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Patent number: 6306899Abstract: This invention relates to anti-viral drugs such as Helioxanthin and its analogs. The present compounds may be used alone or in combination with other drugs for the treatment of Hepatitis B virus (HBV), Hepatitis C virus (HCV), Yellow Fever, Dengue Virus, Japanese Encephalitis, West Nile virus and related flaviviruses. In addition, compounds according to the present invention can be used to prevent hepatoma secondary to virus infection as well as other infections or disease states which are secondary to the virus infection.Type: GrantFiled: August 23, 1999Date of Patent: October 23, 2001Assignees: Yale University, N. Y. Mu, N.T.U., V.G.HInventors: Yung-Chi Cheng, Chen-Kung Chou, Lei Fu, Yueh-Hsiung Kuo, Sheau-Farn Yeh, Juliang Zhu, Yonglian Zhu
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Patent number: 6297399Abstract: Indane compounds of general formulas (7) and (8) and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity as described, wherein in formula (7) R2 to R13, in formula (8) R1 and R3 and R13 are selected from one or more of the same or different of: H, halo, hydroxy, alkoxy, aryloxy, acetoxy, carboxy, alkyl carbonyl, hydro carbonyl, amino, amido, alkylamino, hydroxylamino, amine oxide groups, azo groups, cyano, hydrazino groups, hydrazide groups, hydrazone groups, imide groups, iminoether groups, ureyl groups, oxime, nitro, nitrate, nitrite, nitroso groups, nitrile, heterocyclic groups containing heretro atoms containing one or more of N, O or S, aralkyl groups, mono and polybenzoid aryl groups, substituted aryl groups, thiol, thioureyl, phenylthiol groups, sulphonic acid groups, sulphoxide groups, sulphone groups, alkyl containing 1 to 10 carbon atoms or cycloalkyl groups containing 3 to 8 carbon atoms which may sType: GrantFiled: June 8, 1998Date of Patent: October 2, 2001Assignee: Venantius LimitedInventors: John Walsh, Neil Frankish, Helen Sheridan, William Byrne
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Patent number: 6207865Abstract: A carbonyl compound or a mixture of two or more carbonyl compounds is catalytically hydrogenated in the presence of a Raney copper catalyst in the form of nuggets.Type: GrantFiled: January 11, 2000Date of Patent: March 27, 2001Assignee: BASF AktiengesellschaftInventors: Boris Breitscheidel, Marc Walter, Detlef Kratz, Gerhard Schulz, Manfred Sauerwald
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Patent number: 6184381Abstract: This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmaceuticals, liquid crystal materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compounds as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound.Type: GrantFiled: September 29, 1998Date of Patent: February 6, 2001Assignees: Japan Science & Technology Corp., NKK Corp., Takeda Chemical Industries, Asahi Kasei Kogyo Kabushiki Kaisha, Takasago Intl. Corp.Inventors: Takao Ikariya, Shohei Hashiguchi, Jun Takehara, Nobuyuki Uematsu, Kazuhiko Matsumura, Ryoji Noyori, Akio Fujii
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Patent number: 6162926Abstract: The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C.sub.n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by .sup.3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.Type: GrantFiled: November 13, 1997Date of Patent: December 19, 2000Assignee: Sphere Biosystems, Inc.Inventors: Randall B. Murphy, Stephen R. Wilson, Quing Lu
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Patent number: 6156940Abstract: The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active .alpha.-phenyl-substituted-.beta.-amino alcohols of the formula (3) or optically active .alpha.-non-substituted-.beta.-amino alcohols of the formula (4).The present invention further relates to a process for producing optically active carbinols, comprising reacting a prochiral ketone with, an asymmetric reducing agent obtained from optically active .beta.-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid. All of the formulas (1) to (5) are the same as shown in the specification.Type: GrantFiled: April 8, 1998Date of Patent: December 5, 2000Assignees: Sumika Fine Chemicals Company, Limited, Sumitomo Chemical Company, LimitedInventors: Kenji Saito, Norio Kometani, Azusa Fujiwara, Yukio Yoneyoshi, Gohfu Suzukamo
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Patent number: 6147224Abstract: Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR.sub.1 R.sub.1).sub.n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent aryl or 5 or 6 membered heteroaryl radical having 1 to 3 heteroatoms selected from N, S and O, said aryl or heteroaryl groups being unsubstituted, or substituted with 1 to 3 C.sub.1-6 alkyl or with 1 to 3 C.sub.1-6 fluoroalkyl groups; and the remaining symbols have the meaning described in the specification, have RXR selective retinoid agonist-like activity.Type: GrantFiled: October 1, 1998Date of Patent: November 14, 2000Assignee: Allergan Sales, Inc.Inventors: Vidyasagar Vuligonda, Kwok Yin Tsang, Jayasree Vasudevan, Roshantha A. Chandraratna
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Patent number: 6133488Abstract: With the use of an aqueous solvent containing at least water (e.g. water), and at least one organic solvent selected from esters or ketones and separable from the aqueous solvent, the processes of the invention separate (1) an adamantanediol and an adamantanepolyol having three or more hydroxyl groups per molecule, from a group of adamantanepolyols having plural hydroxyl groups per molecule, distributing the former into an organic solvent layer and the latter into an aqueous solvent layer. Further, (2) an adamantanemonool and the group of adamantanepolyols can be separated from a group of adamantanols having at least one hydroxyl group per molecule with using an aqueous solvent (e.g. aqueous solution of acetic acid) for crystallization of the adamantanemonool.Type: GrantFiled: October 31, 1997Date of Patent: October 17, 2000Assignee: Daicel Chemical Industries, LimitedInventor: Naruhisa Hirai