2,6,6-trialkylcyclohexenyls (e.g., Vitamin A, Etc.) Patents (Class 568/824)
  • Publication number: 20150112091
    Abstract: The present invention relates to compounds of formula (I) wherein R1 signifies a C1-C15 alkyl moiety or a C2 to C18 alkenyl moiety, to their process of production as well as to their use in organic synthesis, especially as intermediates (building blocks) in the synthesis of vitamin A or ?-carotene or derivatives thereof, or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin, preferably vitamin A.
    Type: Application
    Filed: June 14, 2012
    Publication date: April 23, 2015
    Applicant: DSM IP ASSETS
    Inventors: Werner Bonrath, Thomas Netscher, Jan Schütz, Bettina Wüstenberg
  • Publication number: 20150099894
    Abstract: The present invention relates to an improved process for the production of 4-alkanoyloxy-2-methylbutanoic acid, as well as to the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) for the synthesis of organic compounds comprising isoprene (isoterpene) units, such as ?-carotene or other carotenoids (e.g. canthaxanthin, zeaxanthin or astaxanthin) or as vitamin E or vitamin A as well as other structurally similar compounds.
    Type: Application
    Filed: June 5, 2013
    Publication date: April 9, 2015
    Inventors: Werner Bonrath, Jan Schütz, Bettina Wüstenberg, Thomas Netscher
  • Publication number: 20140323550
    Abstract: The present invention relates to a carrier for delivering a substance to extracellular matrix-producing cells in the intestine, the carrier containing a retinoid as a targeting agent, and an agent for treating fibrosis of the intestine utilizing the carrier.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 30, 2014
    Inventors: Tokiyoshi Ayabe, Kiminori Nakamura, Kenjiro Minomi, Yasunobu Tanaka
  • Publication number: 20140323767
    Abstract: The present invention relates to an improved process for the production of 1,3,3-trimethyl-2-(3-methylpent-2-en-4-ynyl)cyclohex-1-ene, highly enriched in the Z-isomer, and the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) the synthesis of vitamin A or ?-carotene or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 30, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jan Schütz, Bettina Wüstenberg
  • Publication number: 20140127187
    Abstract: Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid; a substance delivery carrier for the cell, which comprises the targeting agent; an anti-cancer composition utilizing the targeting agent or the carrier; an anti cancer-associated fibroblast composition; and a method for treatment of cancer.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 8, 2014
    Applicant: Nitto Denko Corporation
    Inventors: Yoshiro Niitsu, Rishu Takimoto
  • Patent number: 8686052
    Abstract: Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid; a substance delivery carrier for the cell, which comprises the targeting agent; an anti-cancer composition utilizing the targeting agent or the carrier; an anti cancer-associated fibroblast composition; and a method for treatment of cancer.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: April 1, 2014
    Assignee: Nitto Denko Corporation
    Inventors: Yoshiro Niitsu, Rishu Takimoto
  • Patent number: 8614345
    Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of specific ruthenium catalysts, or pre-catalysts, in hydrogenation processes for the reduction of ketones and/or aldehydes into the corresponding alcohol respectively. Said catalysts are ruthenium complexes comprising a tetradentate ligand (L4) coordinating the ruthenium with: —two nitrogen atoms, each in the form of a primary or secondary amine (i.e. a NH2 or NH group) or N-alkyl imine functional groups (i.e. a C?N group), and —two sulfur atoms, each in the form of thioether functional groups.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: December 24, 2013
    Assignee: Firmenich SA
    Inventors: Francesco Santoro, Lionel Saudan, Michel Alfred Joseph Saudan, Sylvia Joyeuse Adélaïde Ada Saudan
  • Publication number: 20130267581
    Abstract: Disclosed is a substance delivery carrier for an extracellular-matrix-producing cell in the bone marrow, which comprises a retinoid. Also disclosed in an agent for treating myelofibrosis by utilizing a substance capable of regulating the activity or proliferation of an extracellular-matrix-producing cell in the bone marrow.
    Type: Application
    Filed: June 18, 2013
    Publication date: October 10, 2013
    Inventor: Yoshiro Niitsu
  • Publication number: 20130216611
    Abstract: Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for fibroid lung, which utilized the carrier; and a preparation kit of the therapeutic agent.
    Type: Application
    Filed: April 22, 2013
    Publication date: August 22, 2013
    Applicant: Nitto Denko Corporation
    Inventor: Nitto Denko Corporation
  • Publication number: 20130136789
    Abstract: The present invention relates to a substance delivery carrier for extracellular matrix-producing cells in the kidney, the carrier including a retinoid as a targeting agent, an agent for treating renal fibrosis utilizing the carrier, a process for producing them, a production kit, a method for treating renal fibrosis using the agent for treating renal fibrosis, etc.
    Type: Application
    Filed: June 17, 2011
    Publication date: May 30, 2013
    Applicant: NITTO DENKO CORPORATION
    Inventors: Yoshiro Niitsu, Keiko Kajiwara, Yasunobu Tanaka, Miyono Miyazaki
  • Publication number: 20130072559
    Abstract: Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 21, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Krzysztof PALCZEWSKI, Matthew Batten
  • Publication number: 20130028967
    Abstract: Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for pulmonary fibrosis, which utilized the carrier; and a preparation kit of the therapeutic agent.
    Type: Application
    Filed: October 10, 2012
    Publication date: January 31, 2013
    Applicant: NITTO DENKO CORPORATION
    Inventor: NITTO DENKO CORPORATION
  • Publication number: 20130011336
    Abstract: Agents and methods for imaging a cell and/or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and/or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and/or diagnosis a condition or disease.
    Type: Application
    Filed: September 11, 2009
    Publication date: January 10, 2013
    Applicant: NITTO DENKO CORPORATION
    Inventors: Yoshiro Niitsu, Lei Yu, Gang Zhao, Sang Van, Xinghe Wang, Jian Liu, Sanjib Kumar Das, Yasunobu Tanaka, Keiko Kajiwara, Hirokazu Takahashi, Miyono Miyazaki
  • Publication number: 20120328694
    Abstract: Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for fibroid lung, which utilized the carrier; and a preparation kit of the therapeutic agent.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 27, 2012
    Applicant: Nitti Denko Corporation
    Inventors: Yoshiro Niitsu, Rishu Takimoto
  • Publication number: 20120277180
    Abstract: Provided herein are methods and systems for identifying one or more cofactors such as vitamins for individuals based on the genetic makeup of the individual by detecting the presence or absence of at least one genetic variant, determining a predisposition to cofactor remediable condition, generating a personalized nutritional advice plan based on the genetic variant. Also provided herein are formulations of cofactors determined by the genetic make-up of the individual and methods of determining and producing these formulations.
    Type: Application
    Filed: September 30, 2010
    Publication date: November 1, 2012
    Applicants: VITAPATH GENETICS, INC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Nicholas Marini, Jasper Rine, Dennis Austin Gilbert, Bruce Cohen
  • Publication number: 20120269886
    Abstract: Disclosed are: a substance transfer carrier to an extracellular matrix-producing cell in the lung, which comprises a retinoid; a therapeutic agent for pulmonary fibrosis, which utilized the carrier; and a preparation kit of the therapeutic agent.
    Type: Application
    Filed: June 8, 2012
    Publication date: October 25, 2012
    Applicant: NITTO DENKO CORPORATION
    Inventors: Yoshiro Niitsu, Rishu Takimoto, Kenjiro Minomi, Miyono Miyazaki, Keiko Kajiwara, Yasunobu Tanaka
  • Publication number: 20120209032
    Abstract: Processes for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprise: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 16, 2012
    Applicant: DSM IP ASSETS B.V.
    Inventor: Jochen STANGL
  • Patent number: 8183389
    Abstract: The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: May 22, 2012
    Assignee: DSM IP Assets B.V.
    Inventor: Jochen Stangl
  • Publication number: 20120076852
    Abstract: An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.
    Type: Application
    Filed: September 29, 2011
    Publication date: March 29, 2012
    Applicant: Nitto Denko Corporation
    Inventors: Yoshiro Niitsu, Junji Kato, Yasushi Sato
  • Publication number: 20120077992
    Abstract: The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of solid, for example metallic, structure which allows cross-flow of the material through the porous element. The invention also relates to various types of uses of the device. A device in accordance with the invention is particularly useful to carry out chemical reactions under homogenous and heterogeneous conditions. Such a device hereinafter also referred as reactor may comprises a tube (1) having a cylindrical wall (2) with one inlet end (3) and one outlet end (4). Arranged in the tube (1) is at least one cylindrical porous element (5) consisting of solid metal structure, wherein said porous element (5) comprises a plurality of hollow spaces that are connected to each other and form an interconnected cavity network and wherein the at least one porous element (5) and the cylindrical wall (2) are made in one piece.
    Type: Application
    Filed: June 14, 2010
    Publication date: March 29, 2012
    Inventors: Cédric Hutter, Francesco Mascarello, Philipp Von Rohr, David Ruppen
  • Patent number: 7875751
    Abstract: A novel process for the preparation of highly purified carotenoids from plant extracts, especially the marigold flower extracts, is disclosed. The process includes the formation, isolation and purification of carotenoids, primarily lutein and zeaxanthin, at lower temperatures with the use of at least a polar solvent and at least a non-polar solvent. The highly purified carotenoids so obtained are useful for human consumption, such as nutritional supplements and pharmaceuticals.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: January 25, 2011
    Assignee: Allied Biotech Corporation
    Inventors: Chia-Line Chuang, Hsin-Ke Li, Chong-Nan Chuang
  • Publication number: 20110015412
    Abstract: The invention relates to a process of reacting a primary allylic alcohol with a compound containing a) a metal selected from the group consisting of Ag, Au, Ce, Mn, Ni, Ru, Re, Zn and Co preferably Ag and b) an oxidant like TEMPO (2,2?,6,6?-tetra-methylpiperidin-1-oxyl) or its derivates and c) a co-oxidants selected from the group of peroxodisulfates (PDS), H2505, H2O2, NaOCl, O2, KOCl, and air.
    Type: Application
    Filed: February 15, 2008
    Publication date: January 20, 2011
    Applicant: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Jean-Francois Eckhardt, Manfred L. Eggersdorfer, Ramona Hinze, Wolfgang F. Hölderich, Michael H. Valkenberg
  • Publication number: 20100312016
    Abstract: The present invention relates to a process for the preparation of ?-ionones and/or ?-ionones of the formulae (II) and (III) by acid catalyzed ring-closing of ?-ionone of the formula (I) wherein R1 to R7 are independently selected from hydrogen and C1-C4-alkyl, R8 is selected from hydrogen and C1-C4-alkyl and the hydroxyl group, R9 and R10 are independently selected from hydrogen and C1-C4-alkyl or R9 and R10 form together the oxygen of a carbonyl group, whereby if R9 and R10 form together the oxygen of a carbonyl group no ?-isomer is formed comprising: a) reacting a ?-ionone according to formula (I) in presence of a concentrated Brønsted-acid having a pKs<3, and an organic solvent that is substantially immiscible with the concentrated acid and with an diluted aqueous solution of said acid; b) hydrolysis of the reaction product obtained in step a) by addition of water; and phase separation into an organic phase comprising the ?-ionone and/or the ?-ionone of the formulae (II) and (III) and into an aqueous di
    Type: Application
    Filed: November 12, 2007
    Publication date: December 9, 2010
    Inventors: Andreas Luettin, Claude Stritt
  • Publication number: 20100236321
    Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes.
    Type: Application
    Filed: March 21, 2007
    Publication date: September 23, 2010
    Applicant: Metanomics GmbH
    Inventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
  • Publication number: 20100144659
    Abstract: Disclosed are a novel therapeutic agent and a novel treatment method for cancer. Specifically disclosed are: a targeting agent for a cell selected from the group consisting of a cancer cell and a cancer-associated fibroblast, which comprises a retinoid; a substance delivery carrier for the cell, which comprises the targeting agent; an anti-cancer composition utilizing the targeting agent or the carrier; an anti cancer-associated fibroblast composition; and a method for treatment of cancer.
    Type: Application
    Filed: March 28, 2008
    Publication date: June 10, 2010
    Applicant: Nitto Denko Corporation
    Inventors: Yoshiro Niitsu, Rishu Takimoto
  • Publication number: 20090287006
    Abstract: The invention relates to a process comprising a condensation step wherein a starting aldehyde or ketone is made to react with an ester of an ?-haloacid to form an epoxy compound, whereby the reaction is carried out in the presence of a dipolar aprotic compound selected from the group consisting of 1-methyl-2-pyrrolidone (NMP), hexamethylphosphorous triamide (HMPT), dimethylsulfoxide (DMSO), and urea derivatives of the following formula: (III) wherein R1, R2, R3 and R4 may each independently be H or a C1-C4 alkyl group and whereby R2 and R3 may together form a heterocyclic group.
    Type: Application
    Filed: September 13, 2006
    Publication date: November 19, 2009
    Inventors: Jochen Stangl, Claude Stritt
  • Publication number: 20090076285
    Abstract: The invention relates to a process for the treatment of an aqueous mixture comprising a dipolar aprotic compound, comprising: a) an adsorption step, in which the aqueous mixture is brought into contact with a porous adsorbent, whereby the porous adsorbent is chosen such that the dipolar aprotic compound adsorbs to it more readily than water; b) a desorption step, in which the porous adsorbent is brought into contact with a desorbing agent, whereby a recovery solution is formed comprising the desorbing agent and the dipolar aprotic compound.
    Type: Application
    Filed: December 20, 2006
    Publication date: March 19, 2009
    Inventor: Jochen Stangl
  • Patent number: 7378558
    Abstract: A process for preparing carotenoids, in which the process includes reacting a dialkoxy dialdehyde in a double Wittig condensation with a phosphonium salt of or in a double Wittig-Horner condensation with a phosphonate. The carotenoids include, for example, ?-carotene, zeaxanthin, canthaxanthin, astaxathin, lycopene and croceptin, which are useful as nutraceuticals, food colorants, and feed additives.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: May 27, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Klaus Henrich, Andreas Keller
  • Patent number: 7071228
    Abstract: A method of treating said musculoskeletal and connective tissue inflammations including osteoarthritis and associated articular and periarticular inflammations, and non-articular Rheumatism including capsulitis, tendonitis, fibrositis, and perarticular inflammations is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a patient of an initial dosage of a composition comprising 13-cis-retinoic acid for an initial treatment period, and thereafter administering a maintenance dosage of the composition.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: July 4, 2006
    Inventor: L. Dean Parks
  • Patent number: 6894198
    Abstract: An alkali metal alkoxide or alkaline earth metal alkoxide in granular form.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: May 17, 2005
    Assignee: Degussa AG
    Inventors: Andreas Harthun, Christoph Theis, André Noppe, Josef Metz
  • Publication number: 20040220432
    Abstract: The present invention provides a method for extracting carotenoids from green plant materials using supercritical fluid extraction. A first and second supercritical fluid extraction is performed on the green plant composition at two different pressures to obtain two extracts. The first extract includes substantial amounts of &bgr;-carotene. The second extract may have a controlled concentration of &bgr;-carotene, and includes substantial amounts of lutein.
    Type: Application
    Filed: February 2, 2004
    Publication date: November 4, 2004
    Inventor: Lance B. Crombie
  • Patent number: 6743954
    Abstract: A process for the preparation of optically pure acetylenediols of the formulae R-I and S-I and their further reaction to give meso-zeaxanthin are described.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: June 1, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Klaus Henrich, Klaus Ditrich
  • Patent number: 6743956
    Abstract: The present invention relates to a process for selective liquid phase hydrogenation of carbonyl compounds of the general formula I, where R1 and R2 are identical or different and are each independently hydrogen or a saturated or a mono- or polyunsaturated straight-chain or branched, optionally substituted C1-C20-alkyl radical, an optionally substituted aryl radical or an optionally substituted heterocyclic group, to give the corresponding alcohols of the general formula II where R1 and R2 are each as defined above, in the presence of hydrogen and a Pt/ZnO catalyst.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: June 1, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Mathias Haake, Till Gerlach, Frank Funke
  • Publication number: 20040024264
    Abstract: A process for the preparation of optically pure acetylenediols of the formulae R-I and S-I 1
    Type: Application
    Filed: July 16, 2003
    Publication date: February 5, 2004
    Inventors: Hansgeorg Ernst, Klaus Henrich, Klaus Ditrich
  • Patent number: 6660888
    Abstract: There are disclosed a disulfone compound of formula (1): wherein Ar denotes an aryl group that may have a substituent, R1 denotes a hydrogen atom or a protective group of a hydroxyl group and the wavy line means that the disulfone compound is an E or Z geometrical isomer or a mixture thereof, a method for producing the same, intermediate compounds therefore and a process for producing retinol through the disulfone compound.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: December 9, 2003
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiya Takahashi, Shinzo Seko, Kazutaka Kimura, Noriyuki Doi, Naoto Konya
  • Patent number: 6552219
    Abstract: There are provided a dihalogen derivative represented by formula (2): wherein X represents a halogen atom and R2 represents a protective group for a hydroxyl group; a process for producing the same; and a process for producing vitamin A by use of said dihalogen derivative.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: April 22, 2003
    Assignee: Sumitomo Chemical Company, Ltd.
    Inventors: Toshiya Takahashi, Atsushi Furutani, Shinzo Seko
  • Patent number: 6388124
    Abstract: There is disclosed a dihalo-compound of formula (1): wherein X1 and X2 represent different halogen atoms, R represents a hydrogen atom or a protective group for a hydroxyl group, and a process for producing vitamin A derivative via a sulfone derivative of formula (5): wherein Ar represents an optionally substituted aryl group, and R represents the same as defined above.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: May 14, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiya Takahashi, Shinzo Seko
  • Patent number: 6384270
    Abstract: The invention relates to a process for making vitamin A from ethynyl-retro-&agr;-ionol using an allene acetate as intermediate.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: May 7, 2002
    Assignee: Aventis Animal Nutrition, S.A.
    Inventors: Jean-Erick Ancel, Pierre Meilland
  • Patent number: 6348622
    Abstract: There is provided a compound of the formula[I]: wherein R represents a hydrogen atom or a protective group for a hydroxyl group; and A represents a hydrogen atom, a halogen atom or a group of the formula A1: Q represents Q3: when A represents a halogen atom or a protective group for a hydroyl group, A represents Q4:  wherein R1 and R2 represent a hydrogen atom or a protective group for a hydroxyl group; and when A represents a hydrogen atom, Q is Q2:
    Type: Grant
    Filed: February 9, 2000
    Date of Patent: February 19, 2002
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiya Takahashi, Shinzo Seko, Takashi Miki
  • Publication number: 20010005509
    Abstract: An improved, and useful, topical transdermal delivery composition for the alleviation and treatment of dermatitis, eczema, lupus, dry, cracked, flaking, peeling, and itching skin infirmites of the foot, which has as its constituents, safflower oil, flaxseed oil, vitamin A, tocopheryl linoleate, and tincture of benzoin to restore organic oil lipids that are essential for the health of the dermal areas of the foot.
    Type: Application
    Filed: January 3, 2001
    Publication date: June 28, 2001
    Inventor: Marie Harbeck
  • Patent number: 6245952
    Abstract: The present invention relates to a process for the preparation of alcohols by reduction of the carbonyl function in substrates belonging to the class of aldehydes, ketones, esters or lactones, which substrates may contain unsaturated functions other than carbonyl. This process includes the steps of reacting the carbonyl substrate with stoichiometric amounts of a silane in the presence of catalytic amounts of an active zinc compound which is monomeric and not a hydride, hydrolyzing the thus-obtained siloxane with a basic agent, and separating and purifying, if necessary, the thus-obtained alcohol. The catalytically active compound is generally obtained by the reaction of an oligomeric or polymeric precursor compound of zinc with a complexing agent.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: June 12, 2001
    Assignee: Firmenich SA
    Inventor: Hubert Mimoun
  • Publication number: 20010000028
    Abstract: Nonalcoholic steatohepatitis (NASH) is a disease of the liver characterized by inflammation and damage to the liver cells. Typically, steatohepatitis involves inflammation of the liver related to fat accumulation, and mimics alcoholic hepatitis but is observed in patients who seldom or never consume alcohol. Nonalcoholic steatohepatitis can lead to serious liver damage, and ultimately cirrhosis. The present invention provides methods and compositions useful for the treatment or alleviation of nonalcoholic steatohepatitis and the pharmaceutical formulations for their administration to a human. Specifically, compositions comprised of lecithin, antioxidants and vitamin B complex are administered parenterally, most preferably by oral administration. Specific therapeutic formulations include admixtures of these compounds and specific dosage formulations include daily oral administrations of these compounds in tablet or powder forms.
    Type: Application
    Filed: November 29, 2000
    Publication date: March 15, 2001
    Inventors: Houn Simon Hsia, David Fan
  • Patent number: 6180670
    Abstract: Skin aging and related conditions can be effectively treated with a conjugate of a retinoid and a bioactive organic acid preferably selected from among alpha-hydroxy acids, beta-hydroxy acids, and keto-acids; preferred conjugates include retinyl glycolyl ether and retinyl glycolate (as either the ester or reverse ester).
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: January 30, 2001
    Assignee: Avon Products, Inc.
    Inventors: John A. Duffy, Janice J. Teal, Mark S. Garrison, George P. Serban
  • Patent number: 6150086
    Abstract: Multiple micro-encapsulations of a high concentration oleophilic substance using heat to set the primary particle renders the composition suitable for the production of free-flowing powders or beadlets. Microencapsulation involves forming an emulsion out of the oleophilic substance and a polymer, and then use heat setting and/or cross-linking the polymer encapsulates the oleophilic composition. This process is then repeated with a second polymer or third polymer, and with or without cross-linked via the same or different mechanism to further protect the oleophilic substance.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: November 21, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Stasia Boyle, Kuei-Tu Chang
  • Patent number: 6146825
    Abstract: Multiple micro-encapsulations of a high concentration oleophilic substance using heat to set the primary particle renders the composition suitable for the production of free-flowing powders or beadlets. Microencapsulation involves forming an emulsion out of the oleophilic substance and a polymer, and then use heat setting and/or cross-linking the polymer encapsulates the oleophilic composition. This process is then repeated with a second polymer or third polymer, and with or without cross-linked via the same or different mechanism to further protect the oleophilic substance.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: November 14, 2000
    Assignee: Roche Vitamins Inc.
    Inventors: Stasia Boyle, Kuei-Tu Chang
  • Patent number: 6117845
    Abstract: Disclosed are acid-stable compounds of Formula I: ##STR1## as well as pharmaceutical compositions containing the compounds as active ingredients, and methods to treat cancers in mammal, including humans, by administering one or more of the compounds to a subject in need thereof. The compounds are resistant to acid hydrolysis.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: September 12, 2000
    Assignee: Ohio State University Research Foundation
    Inventors: Margaret Clagett-Dame, Robert W. Curley, Jr., Kevin L. Weiss, Linda A. Tephly, Vishal Sikri
  • Patent number: 6087541
    Abstract: There is disclosed a novel polyene alcohol derivative of the formula [I]: ##STR1## wherein, R represents a hydrogen atom or a protective group for a hydroxy group, andY represents the following group: ##STR2## wherein, R represents a hydrogen atom or a protective group for a hydroxy group, and Y represents the following group, and a production method thereof.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: July 11, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiya Takahashi, Yasunobu Miyamoto
  • Patent number: RE40912
    Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: September 8, 2009
    Assignee: The Catholic University of America
    Inventor: Frederick Khachik
  • Patent number: RE40931
    Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: October 6, 2009
    Assignee: The Catholic University of America
    Inventor: Frederick Khachik
  • Patent number: RE40938
    Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin in its pure free form, apart from chemical impurities and other carotenoids. Lutein may be used as an analytical standard or in cancer prevention trials and as a safe and effective color additive for human food.
    Type: Grant
    Filed: February 5, 2007
    Date of Patent: October 13, 2009
    Assignee: The Catholic University of America
    Inventor: Frederick Khachik