Halogenation Of Acyclic Carbon Patents (Class 570/196)
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Patent number: 8680346Abstract: The subject of the invention is a process for the preparation of 2,3-dichloro-1,1,1-trifluoropropane by chlorination of 3,3,3-trifluoropropene at a pressure greater than 2 bar. Application in the synthesis of 1234yf.Type: GrantFiled: September 11, 2009Date of Patent: March 25, 2014Assignee: Arkema FranceInventors: Anne Pigamo, Michel Devic, Laurent Wendlinger
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Publication number: 20130178620Abstract: The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.Type: ApplicationFiled: September 14, 2012Publication date: July 11, 2013Inventors: Beverly L. Wolgast, CHARLES A. GILSON, III, SHELLEY AYTES, SCOTT A. ESTRADA, DIPANJAN SENGUPTA, BRIAN SMITH, MAX REY, ULRICH WEIGL, HEIDEDORE JLSABETH REY-PAPINA
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Publication number: 20130165658Abstract: This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.Type: ApplicationFiled: June 9, 2011Publication date: June 27, 2013Inventors: Gennady Nisnevich, Mark Gandelman, Kseniya Kulbitski
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Publication number: 20120142967Abstract: The present invention relates to processes and intermediates useful in the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin), a serotonin (5-HT) receptor modulator that is useful in the treatment of, for example, central nervous system disorders, such as obesity.Type: ApplicationFiled: June 17, 2010Publication date: June 7, 2012Inventors: John A. DeMattei, Marlon Carlos, Ryan O. Castro, Tsung-Hsun Chuang, Mark Allen Hadd, Xiao-Xiong Lu, Mark Macias, Stephen M. Shaw
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Publication number: 20110015438Abstract: The present invention provides processes and intermediates useful in the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a serotonin (5-HT) receptor agonist that is useful in the treatment or prophylaxis of, for example, central nervous system disorders, such as obesity.Type: ApplicationFiled: March 3, 2009Publication date: January 20, 2011Inventors: Marlon V. Carlos, Ryan O. Castro, Tawfik Gharbaoui, Xiao-Xiong Lu, You-An Ma, Nicholas D. San Martin
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Publication number: 20100168484Abstract: [PROBLEMS] To provide a simpler method for producing a high-quality chlorinated aromatic hydrocarbon (e.g., cumylchloride), which can be used as a cationic polymerization initiator. [MEANS FOR SOLVING PROBLEMS] A chlorinated aromatic hydrocarbon can be produced by repeating both (a) the step of performing chlorination reaction by stirring an organic solution containing a compound represented by Ar(R1C?CH2)n with an aqueous hydrochloric acid solution having a hydrochloric acid concentration of 30% by weight or higher and (b) the step of removing the water phase in part or whole from the reaction solution produced in the step (a), and then adding an aqueous hydrochloric acid solution having a hydrochloric acid concentration of 30% by weight or higher to the reaction solution, until the chlorination reaction rate of the compound reaches a predetermined level.Type: ApplicationFiled: August 3, 2006Publication date: July 1, 2010Inventors: Susumu Kyotani, Naoki Furukawa
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Patent number: 7271302Abstract: The present invention relates to processes for the bromination of organic compounds, and to bromination microreactors for carrying out these processes.Type: GrantFiled: September 19, 2000Date of Patent: September 18, 2007Assignee: Merck Patent GesellschaftInventors: Kai Fabian, Joeran Stoldt, Hanns Wurziger, Norbert Schwesinger
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Publication number: 20030105350Abstract: A process for thermal benzylic bromination of a wide variety of benzylic compounds is described. Bromine is used as the bromination agent. Moderate temperatures are employed and the process can be used to produce in relatively pure form either mono- or dibrominated benzylic bromination products.Type: ApplicationFiled: December 5, 2001Publication date: June 5, 2003Inventors: Max K. Mortensen, Hassan Y. Elnagar, Ranjit K. Roy, Robert C. Herndon,, Robert H. Allen, David A. Caillet
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Patent number: 6201161Abstract: Disclosed is a method of removing about 0.05 to about 20 mole % of a benzaldehyde or benzotrihalide from a mixture with a liquid compound that boils within about −10 to about ±5° C. of the boiling point of the benzaldehyde or benzotrihalide. To the mixture is added a benzotrihalide in an amount about stoichiometric to about 10 mole % in excess of stoichiometric, or, respectively, a benzaldehyde in an amount about stoichiometric with the amount of said benzotrihalide, where said benzaldehyde and said benzotrichloride react to form a benzalhalide and a benzoylhalide. The product mixture is distilled to isolate the products.Type: GrantFiled: April 17, 2000Date of Patent: March 13, 2001Assignee: Occidental Chemical CorporationInventors: Pravin M. Khandare, Dean R. Lagerwall, Daniel R. Thielen
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Patent number: 6187977Abstract: The present invention thus provides a process for producing (D) a chlorinated hydrocarbon compound of the general formula (2): CnR1mHk(CR2R3Cl)j (2) [wherein n is an integer of 1 to 12, m and k each independently is an integer of 0 to 25, j is an integer of 1 to 10; R1 represents an atom selected from the group consisting of chlorine, bromine, iodine, oxygen, nitrogen, sulfur and phosphorus and, when m is 2 or more, the two or more R1 groups may be the same or different, the group CnR1mHk having a valence of j does not contain any tertiary carbon-hydrogen bond; and R2 and R3 each independently represents a saturated aliphatic hydrocarbon group containing 1 to 5 carbon atoms or a group derived therefrom by substitution of a halogen atom or atoms for some hydrogen atom or atoms thereof and not containing a tertiary carbon-hydrogen bond],which process comprises adding (C) a protic acid to a mixture of (A) a compound of the general formula: CnR1mHk(CHR2R3)j (1) [wherein mType: GrantFiled: April 27, 1999Date of Patent: February 13, 2001Assignee: Kaneka CorporationInventors: Takahiro Ohishi, Takeshi Kawamura, Akihisa Hirota, Takuya Maeda, Hiroshi Tsuneishi, Shun Wachi
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Patent number: 6133468Abstract: Substituted benzyl bromides of the formula I ##STR1## where at least one substituent R.sup.1-5 is an electron-attracting group such as fluorine, chlorine, bromine, C.sub.1 -C.sub.4 -alkoxycarbonyl, cyano or nitro, and the other substituents R.sup.1-5 are hydrogen or methyl,are prepared by bromination of substituted toluenes of the formula II ##STR2## with a brominating agent at from 20 to 95.degree. C.Type: GrantFiled: January 11, 2000Date of Patent: October 17, 2000Assignee: BASF AktiengesellschaftInventors: Horst Wingert, Norbert Gotz, Michael Keil, Bernd Muller
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Patent number: 5821393Abstract: The present invention relates to a process for the preparation of an aromatic bromoalkyl-substituted hydrocarbon compound, in which an alkyl-substituted aromatic hydrocarbon compound is reacted with a brominating agent in the presence of water.Type: GrantFiled: December 18, 1996Date of Patent: October 13, 1998Assignee: Hoechst AktiengesellschaftInventors: Hans Millauer, Frank Kuber
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Patent number: 5672791Abstract: Nuclear-halogenated benzotrichlorides are prepared in a particularly advantageous manner from the corresponding nuclear-halogenated benzotrifluorides by reacting nuclear-halogenated benzotrifluorides with silicon tetrachloride in the presence of catalytic amounts of aluminium trichloride.Type: GrantFiled: January 24, 1996Date of Patent: September 30, 1997Assignee: Bayer AktiengesellschaftInventors: Fritz Doring, Reinhold Gehring, Josef Heinrich
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Patent number: 5502261Abstract: The present invention relates to a process for preparing 2,2'-bis(halomethyl)-1,1'-binaphthyl, by reacting 2,2'-dimethyl-1,1'-binaphthyl in the presence of a solvent with a halogenating agent under the action of light having a wavelength of from 10.sup.-5 to 10.sup.-8 m in the presence or absence of a free-radical former at from -10.degree. to 120.degree. C.Type: GrantFiled: March 21, 1995Date of Patent: March 26, 1996Assignee: Hoechst AktiengesellschaftInventors: Hans-Jerg Kleiner, Dieter Regnat, Horst Ro/ schert
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Patent number: 5157173Abstract: 4-chlorobenzotrichloride was prepared by the chlorination of p-xylene in the vapor phase at a temperature above about 200.degree. C. in the presence of an activated carbon catalyst and water. An approximately 75 percent calculated yield was obtained at 250.degree. C. using a wide-pore activated carbon catalyst.Type: GrantFiled: September 24, 1991Date of Patent: October 20, 1992Assignee: DowElancoInventors: Michael A. DesJardin, Clark P. Allphin
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Patent number: 5144067Abstract: Disclosed is a process for the coproduction of (1) an alkyl iodide and (2) an .alpha.-iodocarboxylic acid, a mono-.alpha.-iodocarboxylic anhydride or a mixture thereof which comprises contacting a mixture of an iodine compound and a carboxylic anhydride with a peroxide at an elevated temperature.Type: GrantFiled: September 29, 1989Date of Patent: September 1, 1992Assignee: Eastman Kodak CompanyInventors: Joseph R. Zoeller, Michael R. Cushman, Regina M. Moncier, Brent A. Tennant
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Patent number: 5110425Abstract: A terminally chlorinated normal alkane hydrocarbon is produced at high terminal selectivity, by adsorbing a normal alkane into a select zeolite and chlorinating the adsorbed alkane in the zeolite. The zeolite may be of a type having internal channels of diameter slightly larger than that of the alkane, and substantially no internal chambers, and may be selected from the pentasil family of zeolites. The chlorination reaction may be conducted under heating to enhance terminal selectivity even further, in many cases to levels approaching 100%.Type: GrantFiled: October 10, 1990Date of Patent: May 5, 1992Assignee: Inrad, Inc.Inventors: Nicholas J. Turro, James R. Fehlner
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Patent number: 4971664Abstract: A terminally chlorinated normal alkane hydrocarbon is produced at high terminal selectivity, by adsorbing a normal alkane into a select zeolite and chlorinating the adsorbed alkane in the zeolite. The zeolite may be of a type having internal channels of diameter slightly larger than that of the alkane, and substantially no internal chambers, and may be selected from the pentasil family of zeolites. The chlorination reaction may be conducted under heating to enhance terminal selectivity even further, in many cases to levels approaching 100%.Type: GrantFiled: July 13, 1988Date of Patent: November 20, 1990Assignee: Inrad, Inc.Inventors: Nicholas J. Turro, James R. Fehlner
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Patent number: 4967026Abstract: A process is described for preparing chloromethyl phenethyl bromide, in which phenethyl bromide is reacted with HCl and formaldehyde in the presence of zinc chloride as the catalyst, and in a chlorinated hydrocarbon as the solvent. The product is produced in yields in excess of 70%, the para isomer constituting more than 75% of the product which contains a mixture of ortho, meta and para isomers.Type: GrantFiled: May 11, 1989Date of Patent: October 30, 1990Assignee: Bromine Compounds Ltd.Inventor: Stephen Daren
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Patent number: 4956055Abstract: A process is disclosed for preparing bidentate ligands of the formula: ##STR1## wherein: each Ar is independently selected from aromatic ring compounds having 6 up to 14 carbon atoms, e.g., phenyl, naphthyl, phenanthryl and anthracenyl;the x bonds and the y bonds are attached to adjacent carbon atoms on the ring structures;each R, when present as a substituent, is independently selected from alkyl, alkoxy, aryloxy, aryl, aralyky, alkaryl, alkoxyalky, cycloaliphatic, halogen, alkanoyl, alkanoyloxy, alkoxycarbonyl, carboxyl, cyano or formyl radicals;n is a whole number in the range of 0-4 where Ar is phenyl; 0-6 where Ar is naphthyl; and 0-8 where Ar is phenanthryl or anthracenyl;each R.sub.1 and R.sub.2 is independently selected from alkyl, aryl, aralkyl, alkaryl or cycloaliphatic radicals, or substituted derivatieves thereof;each R.sub.3 and R.sub.4 is independently selected from hydrogen and the R.sub.Type: GrantFiled: July 24, 1989Date of Patent: September 11, 1990Assignee: Eastman Kodak CompanyInventor: Thomas A. Puckette
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Patent number: 4954227Abstract: A process is disclosed for preparing bidentate ligands of the formula: ##STR1## wherein: each AR is independently selected from aromatic ring compounds having 6 up to 14 carbon atoms, e.g., phenyl, naphthyl, phenanthryl and anthracenyl;the x bonds and the y bonds are attached to adjacent carbon atoms on the ring structures;each R, when present as a substituent, is independently selected from alkyl, alkoxy, aryloxy, aryl, aralkyl, alkaryl, alkoxyalkyl, cycloaliphatic, halogen, alkanoyl, alkanoyloxy, alkoxycarbonyl, carboxyl, cyano or formyl radicals;n is a whole number in the range of 0-4 were Ar is phenyl; 0-6 where Ar is naphthyl; and 0-8 where Ar is phenanthryl or anthracenyl;each R.sub.1 and R.sub.2 is independently selected from alkyl, aryl, aralkyl, alkaryl or cycloaliphatic radicals, or substituted derivatives thereof;each R.sub.3 and R.sub.4 is independently selected from hydrogen and the R.sub.Type: GrantFiled: July 24, 1989Date of Patent: September 4, 1990Assignee: Eastman Kodak CompanyInventor: Thomas A. Puckette
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Patent number: 4879416Abstract: The process for preparing a bidentate ligand comprising the steps,(1) contacting with ozone under ozonolysis conditions a suspension in a hydroxylic reaction medium of phenanthrene or a phenanthrene derivative to form an ozonated intermediate,(2) contacting said ozonated intermediate with a reducing agent under conditions appropriate to form the corresponding diol,(3) contacting said diol with a latent displaceable functional group under conditions appropriate to convert the diol to the corresponding difunctional biaryl compound, and(4) contacting said difunctional biaryl compound, with an anion of N, P, As, Sb or Bi under conditions appropriate to form the desired bidentate ligand.Type: GrantFiled: November 23, 1987Date of Patent: November 7, 1989Assignee: Eastman Kodak CompanyInventors: Thomas A. Puckette, Thomas J. Devon, Gerald W. Phillips, Jerome L. Stavinoha
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Patent number: 4879008Abstract: A process is disclosed for preparing bidentate ligands of the formula: ##STR1## wherein: each Ar is independently selected from aromatic ring compounds having 6 up to 14 carbon atoms, e.g., phenyl, naphthyl, phenanthryl and anthracenyl;the x bonds and y bonds are attached to adjacent carbon atoms on the ring structure;each R, when present as a substituent, is independently selected from alkyl, alkoxy, aryloxy, aryl, aralkyl, alkaryl, alkoxyalkyl, cycloaliphatic, halogen, alkanoyl, alkanoyloxy, alkoxycarbonyl, carboxyl, cyano or formyl radicals;n is a whole number in the range of 0-4 were Ar is phenyl; 0-6 where Ar is naphthyl; and 0-8 where Ar is phenanthryl or anthracenyl;each R.sub.1 and R.sub.2 is independently selected from alkyl, aryl, aralkyl, alkaryl or cycloaliphatic radicals, or substituted derivatives thereof;each R.sub.3 and R.sub.4 is independently selected from hydrogen and the R.sub.Type: GrantFiled: November 9, 1987Date of Patent: November 7, 1989Assignee: Eastman Kodak CompanyInventor: Thomas A. Puckette
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Patent number: 4814467Abstract: A process for chlorinating compounds containing a carbon atom bonded to a hetero-atom selected from the group consisting of oxygen, nitrogen and sulfur; said process comprises contacting the carbon hetero-atom containing compound with a chloro phosphorus complex of the formulaRP.sup..sym. CL.sub.3 P.sup..crclbar. Cl.sub.6wherein R is selected from the group consisting of aryl, substituted aryl, alkyl and substituted alkyl, so that the hetero-atom is replaced by at least one chlorine atom; compounds capable of being chlorinated can include, for example, carboxylic acids, acid chlorides, ketones, aldehydes, alcohols, epoxides, esters, anhydrides, ethers, thiols, and aromatic nitro groups; the reaction can be extended to compounds containing the carbon to chlorine bond alpha to a carbon atom containing at least one hydrogen atom, it can be further dehydrochlorinated, e.g., by either heating to a temperature ranging from about 50.degree. C. to about 300.degree. C. or by reaction with a base selected, e.g.Type: GrantFiled: January 22, 1988Date of Patent: March 21, 1989Assignee: ICI Americas Inc.Inventors: Elliott Bay, Andrea Leone-Bay, Peter E. Timony
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Patent number: 4783562Abstract: Trichloromethyl-substituted aromatic compounds are obtained by the chlorination of thioethers of the formula ##STR1## wherein Ar represents an optionally substituted aryl radial,X.sub.1 denotes hydrogen or halogen, andR.sup.1 represents optionally substituted alkyl, aralkyl, the nitrile group, an optionally substituted aryl radical or the group ##STR2## wherein Ar and X have the meaning given. The compounds, of which some are new, can be used as intermediate products for plant protection agents.Type: GrantFiled: February 25, 1982Date of Patent: November 8, 1988Assignee: Bayer AktiengesellschaftInventor: Albrecht Marhold
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Patent number: 4767885Abstract: Sterically hindered binifers are made as well as utilized to produce telechelic polyisobutylenes. The telechelic polymers can be produced at high temperatures, for example minus 30.degree. C.Type: GrantFiled: August 6, 1984Date of Patent: August 30, 1988Assignee: University of AkronInventor: Joseph P. Kennedy
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Patent number: 4563529Abstract: A trifluoromethylpyridine selected from the group consisting of .alpha.-trifluoromethylpyridine, .gamma.-trifluoromethylpyridine, a bis(trifluoromethyl)pyridine and chlorides thereof which have 1 to 3 chlorine atoms in its pyridine nucleus is produced by reacting a pyridine derivative selected from the group consisting of .alpha.-picoline, .gamma.-picoline and a lutidine with chlorine and anhydrous hydrogen fluoride at a temperature of 300.degree. to 600.degree. C. in a vapor phase in the presence of a diluent and a catalyst comprising a fluoride of a metallic element selected from the group consisting of aluminum, chromium, iron, nickel, manganese, cobalt and copper.Type: GrantFiled: June 4, 1981Date of Patent: January 7, 1986Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Yasuhiro Tsujii, Shigeyuki Nishimura
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Patent number: 4513154Abstract: A process for consecutive-competitive gas phase halogenation of organic compounds, i.e. alkanes, alkenes and benzene, alkyl benzenes and alkenyl benzenes containing labile hydrogens and having no more than 12 and 9 carbon atoms, respectively, in a thin reaction film on the surface of a porous barrier for production of highly halogenated products by substantial suppression of diffusion of partially halogenated intermediates away from the reaction film is disclosed.Type: GrantFiled: July 28, 1980Date of Patent: April 23, 1985Assignee: Allied CorporationInventor: Bruce E. Kurtz
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Patent number: 4489210Abstract: The invention relates to a process for the halogenation of organic compounds in the liquid phase using gaseous halogenating agents, the gaseous halogenating agents being metered into the reaction vessel at such an entry velocity that a gas jet is formed in the reaction mixture at the point of entry of the halogenating agent and the formation of individual gas bubbles at the point of entry is prevented.Type: GrantFiled: July 30, 1982Date of Patent: December 18, 1984Assignee: Bayer AktiengesellschaftInventors: Helmut Judat, Ulrich Schnegg, Karlfried Wedemeyer
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Patent number: 4465865Abstract: A method of preparing terephthalic aldehyde or isophthalic aldehyde from p-xylene or m-xylene, which comprises chlorinating the side chain or p or m xylene to a chlorination degree of 2.5 to 3.5, and thereafter contacting the so-chlorinated product with hexamethylenetetramine in aqueous solution at elevated temperature whereby the corresponding aldehyde is obtained.Type: GrantFiled: February 22, 1982Date of Patent: August 14, 1984Assignee: Dynamit Nobel AktiengesellschaftInventors: Fritz Englander, Klaus-Dieter Steffen
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Patent number: 4423263Abstract: A process for the selective side-chain halogenation of alkylaromatic hydrocarbons, consisting of reacting the hydrocarbon with an N-halogenoamine in the presence of a proton donor and a metal ion.Type: GrantFiled: June 29, 1982Date of Patent: December 27, 1983Assignee: ANIC, S.p.A.Inventors: Francesco Minisci, Giancarlo Serboli, Edoardo Platone
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Patent number: 4362884Abstract: Organosilicon compounds referred to as silacrown ethers or "silacrowns" are of the general formula: ##STR1## where R.sup.1 and R.sup.2 are organic radicals or hydrogen and n is an integer between 4 and 10 inclusive. Silacrown ethers are prepared by reacting polyethylene glycol with substituted silanes under conditions promoting cyclization over polymerization. Silacrown ethers may be employed as phase-transfer catalysts in solution or immobilized on siliceous supports.Type: GrantFiled: November 23, 1981Date of Patent: December 7, 1982Assignee: Petrarch Systems, Inc.Inventor: Barry C. Arkles
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Patent number: 4331821Abstract: A process for the monohalogenation of alkylbenzenes in the .alpha.-position is disclosed wherein an alkylbenzene reactant containing a hydrogen atom in the .alpha.-position is contacted with a halogen and the reaction mixture is withdrawn such that the amount of monohalogenated alkylbenzene formed is no greater than 33 mol percent in the reaction mixture. Also disclosed are novel monohalogenated alkylbenzenes of the formula ##STR1## in which R.sup.7 represents trifluoromethoxy, trifluoromethylthio or 2-perfluoropropyl or also, if R.sup.8 represents chlorine, represents trifluoromethyl and, furthermore, ifR.sup.8 and R.sup.9 represent trifluoromethyl, represents hydrogen,R.sup.8 represents hydrogen or also, if R.sup.7 represents trifluoromethyl or trifluoromethoxy, represent chlorine and also, if R.sup.7 represents hydrogen and R.sup.9 represents trifluoromethyl, denotes trifluoromethyl andR.sup.9 represents hydrogen and, if R.sup.7 represents hydrogen and R.sup.Type: GrantFiled: November 24, 1980Date of Patent: May 25, 1982Assignee: Bayer AktiengesellschaftInventors: Rudiger Schubart, Erich Klauke, Klaus Naumann, Rainer Fuchs
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Patent number: 4329525Abstract: A compound is chlorinated with chlorine to produce chlorinated product and hydrogen chloride byproduct. Recovered hydrogen chloride byproduct is contacted with oxygen and a molten salt mixture containing the higher and lower valent chlorides of a multivalent metal, such as cuprous and cupric chloride, to effect recovery of the hydrogen chloride by enriching the molten salt content of the higher valent chloride. The molten salt, enriched in higher valent chloride, is then dechlorinated by use of a stripping gas, preferably hydrogen chloride, to produce a gaseous effluent containing stripped chlorine and the stripping gas, which is then recycled to the chlorination step. The presence of stripping gas, as a diluent, improves the chlorination operation.Type: GrantFiled: February 21, 1978Date of Patent: May 11, 1982Assignee: The Lummus CompanyInventors: Herbert Riegel, Vincent Strangio, Morgan C. Sze
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Patent number: 4306102Abstract: p-Tert.butylbenzotribromide and the derivatives thereof which is halogen-substituted at the nucleus are prepared under side chain halogenation conditions by bromination of p-tert.butyltoluene and its derivatives substituted at the nucleus by halogen. Practically no undesired bromination in the nucleus or at the tert.butyl radical takes place.By partial saponification of the benzotribromide the corresponding benzoyl bromide is obtained. Further saponification of the latter or complete saponification of the benzotribromide yields p-tert.butylbenzoic acid and derivatives thereof which are halogen substituted at the nucleus, the esters of which can be used in pharmacology.Type: GrantFiled: November 14, 1979Date of Patent: December 15, 1981Assignee: Hoechst AktiengesellschaftInventors: Franz Landauer, Georg Schaeffer
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Patent number: 4256907Abstract: A process for the preparation of a substituted vinyl-cyclopropanecarboxylic acid ester of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1-4 carbon atoms or halogen,R.sup.3 is halogen, phenoxy or phenoxy substituted by alkyl with 1-4 carbon atoms or by halogen,R.sup.4 is halogen or methyl, andn is 0, 1, 2, 3 or 4,comprising saponifying with alkali an ester of the formula ##STR2## in which R.sup.5 is alkyl with 1-4 carbon atoms,thereby to replace R.sup.5 by an alkaline salt group, and directly reacting such salt without intermediate purification with a benzyl chloride of the formula ##STR3## Advantageously the benzyl chloride is obtained by the gas-phase photochlorination of a compound of the formula ##STR4## the chlorination proceeding to about 25 to 75%, and the chlorination mass being employed directly without isolation.Type: GrantFiled: April 24, 1978Date of Patent: March 17, 1981Assignee: Bayer AktiengesellschaftInventors: Klaus Naumann, Rudiger Schubart, Thomas Schmidt
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Patent number: 4226783Abstract: A process for .alpha.-chlorination of side chains of electronegatively substituted aromatic compounds with dichlorine monoxide.Type: GrantFiled: July 3, 1978Date of Patent: October 7, 1980Assignee: E. I. Du Pont de Nemours and CompanyInventor: Frank D. Marsh