Abstract: The present invention relates to processes and intermediates useful in the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin), a serotonin (5-HT) receptor modulator that is useful in the treatment of, for example, central nervous system disorders, such as obesity.

Abstract: The present invention relates to processes for the bromination of organic compounds, and to bromination microreactors for carrying out these processes.

Abstract: The present invention is an industrially advantageous process for isopropyl chloride production in which the catalytic activity can be maintained under the milder reaction conditions than in the conventional processes, and which requires no special reactor. Propylene and hydrogen chloride is reacted in a gas phase, in the presence of iron or a halogenated aluminum oxide (preferably, aluminum oxide reacted with hydrogen chloride). Preferably, a temperature during the reaction is 20 to 100° C., and a pressure of the reaction is 1013 to 3039 hPa (absolute pressure).

Abstract: A process for the halogenation of activated methylene and methine compounds with at least equimolar amounts of an electrophilic halogenation reagent, which comprises reacting said activated methylene and methine compounds in the presence of catalytic amounts of a titanium compound of the formula I or of a titanium compound of the formula II

Abstract: Disclosed is a method of removing about 0.05 to about 20 mole % of a benzaldehyde or benzotrihalide from a mixture with a liquid compound that boils within about −10 to about ±5° C. of the boiling point of the benzaldehyde or benzotrihalide. To the mixture is added a benzotrihalide in an amount about stoichiometric to about 10 mole % in excess of stoichiometric, or, respectively, a benzaldehyde in an amount about stoichiometric with the amount of said benzotrihalide, where said benzaldehyde and said benzotrichloride react to form a benzalhalide and a benzoylhalide. The product mixture is distilled to isolate the products.

Abstract: A novel 3-substituted .alpha.,.beta.-dibromoethylbenzene of formula (I): ##STR1## wherein X represents a halogen atom or a trihalomethyl group, which is useful as an intermediate for pharmaceuticals or agricultural chemicals, is prepared by a simple and high yield process which comprises reacting a 3-substituted .alpha.-bromoethylbenzene represented by formula (II): ##STR2## wherein X is as defined above, or a 3-substituted ethylbenzene represented by formula (III): ##STR3## wherein X is as defined above, with bromine in the presence of a quaternary ammonium salt.

Abstract: The present invention relates to a process for preparing 2,2'-bis(halomethyl)-1,1'-binaphthyl, by reacting 2,2'-dimethyl-1,1'-binaphthyl in the presence of a solvent with a halogenating agent under the action of light having a wavelength of from 10.sup.-5 to 10.sup.-8 m in the presence or absence of a free-radical former at from -10.degree. to 120.degree. C.

Abstract: Compounds such as ##STR1## wherein R is F, CF.sub.3, CF.sub.2 H, CHF CF.sub.3 or CF.sub.2 CF.sub.3, as well as related compounds containing chlorine, are used as solvents in halogenation processes.

Abstract: 4-chlorobenzotrichloride was prepared by the chlorination of p-xylene in the vapor phase at a temperature above about 200.degree. C. in the presence of an activated carbon catalyst and water. An approximately 75 percent calculated yield was obtained at 250.degree. C. using a wide-pore activated carbon catalyst.

Abstract: Disclosed is a process for the coproduction of (1) an alkyl iodide and (2) an .alpha.-iodocarboxylic acid, a mono-.alpha.-iodocarboxylic anhydride or a mixture thereof which comprises contacting a mixture of an iodine compound and a carboxylic anhydride with a peroxide at an elevated temperature.

Abstract: A method is provided for forming (3-trifluoromethylphenyl)acetonitrile through the intermediate .alpha.,.alpha.,.alpha.-trifluoro-.alpha.'-chloro-m-xylene. This intermediate is formed by selective chlorination of .alpha.,.alpha.,.alpha.'-trichloro-m-xylene under conditions which maximize yield and minimize the formation of undesired, non-recyclable chlorinated by-products.

Abstract: A process is described for preparing chloromethyl phenethyl bromide, in which phenethyl bromide is reacted with HCl and formaldehyde in the presence of zinc chloride as the catalyst, and in a chlorinated hydrocarbon as the solvent. The product is produced in yields in excess of 70%, the para isomer constituting more than 75% of the product which contains a mixture of ortho, meta and para isomers.

Abstract: A process for producing brominated acenaphthylene condensates of the formula: ##STR1## wherein x is 1 or 2, y is an integer from 1 to 6 and n is 1 or more, from elementary units of the following formulas: ##STR2## wherein y is as defined above, comprising, (A) brominating the side chain of the acenaphthene with 0.2 to 2.0 times as many moles of bromine as acenaphthene, said bromination initiated by ultraviolet radiation or by a radical initiator in a halogenated hydrocarbon solvent, (B) adding a Lewis acid catalyst to the reaction solution of step (A) to promote the condensation of the brominated acenaphthene product of step (A), (C) adding to the reaction solution of step (B) an equimolar or more amount of bromine relative to the amount of acenaphthene starting material, to further brominate and condense the brominated acenaphthene and/or brominated acenaphthene condensates; and (D) dehydrobrominating the brominated acenaphthene condensates.

Abstract: A novel process for the selective chlorination of p-tert-butyltoluene to p-tert-butylbenzyl chloride.

Abstract: A process is provided for the production of N-substituted morpholines and piperidines of the formula ##STR1## comprising the steps of (a) reacting a methallylbenzene of the formulas ##STR2## wherein R.sub.1 is H or a straight or branched chained C.sub.1 -C.sub.4 alkyl group, alone or in admixture with a corresponding isobutenylbenzene of the formula ##STR3## wherein R.sub.1 is as defined above, with hydrogen bromide in the presence of a peroxide to yield, respectively, the corresponding bromine compound of the formula ##STR4## wherein R.sub.1 is as defined above, alone or in admixture with a bromine compound of the formula ##STR5## wherein R.sub.1 is as defined above and wherein the bromine atom is in the secondary or tertiary position, and(b) reacting the resultant bromine compound of formula IV, alone or in admixture with the corresponding bromine compound of Formula V, with a compound of the formula ##STR6## wherein R.sub.2, R.sub.3, R.sub.4 and R.sub.

Abstract: A process for the selective side-chain halogenation of alkylaromatic hydrocarbons, consisting of reacting the hydrocarbon with an N-halogenoamine in the presence of a proton donor and a metal ion.

Abstract: Organosilicon compounds referred to as silacrown ethers or "silacrowns" are of the general formula: ##STR1## where R.sup.1 and R.sup.2 are organic radicals or hydrogen and n is an integer between 4 and 10 inclusive. Silacrown ethers are prepared by reacting polyethylene glycol with substituted silanes under conditions promoting cyclization over polymerization. Silacrown ethers may be employed as phase-transfer catalysts in solution or immobilized on siliceous supports.

Abstract: Alpha-chlorinated cumene derivatives are prepared by chlorinating cumene derivatives in the presence of light. The chlorination may be taken to 100 percent conversion when performed in a solvent, e.g., m-dichlorobenzene.

Abstract: The invention provides a process for producing beta-bromoethyl aromatic compounds comprising reacting hydrogen bromide with a vinyl aromatic compound in the presence of an azo radical initiator to effect the antimarkovnikoff addition of HBr to the vinyl double bond.