Sleep Or Relaxation Inducing Therapy (e.g., Direct Nerve Stimulation, Hypnosis, Analgesia) Patents (Class 600/26)
  • Patent number: 11226125
    Abstract: An energy optimization system for a load of perishable goods in temperature controlled storage, wherein a thermal profile of the load is developed, which is then used, in connection with temperature readings of the air and goods to simulate an expected temperature of the goods over an absolute or relative time duration at one or more set points. The simulation allows an optimal energy efficient set point to be determined, which may then be used to make the HVAC unit of the temperature controlled storage zone more energy efficient.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: January 18, 2022
    Assignee: Lettuce Box, Inc.
    Inventors: Mark Hogan, Darryl Kuhn
  • Patent number: 11179540
    Abstract: Systems and methods to facilitate sleep are described. In on example, a cognitive alarm clock system for children learns sleep patterns and activities towards recommending sleep schedules and teaching independence. The system may detect the cognitive state of a child based on voice or cry pattern recognition, a time of day or night, scheduled activities, and social context, among other factors. The system may initiate actions to facilitate sleep in response to the cognitive factors. For example, the system may adjust lighting or push back a wakeup time. In another example, the system may use the cognitive analysis to teach children good sleeping habits by making recommendations to facilitate a good night's rest and encourage independence.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: November 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Maja Vukovic, Michael S. Gordon, Jinho Hwang, Ryan T. Gordon
  • Patent number: 11179539
    Abstract: Systems and methods to facilitate sleep are described. In on example, a cognitive alarm clock system for children learns sleep patterns and activities towards recommending sleep schedules and teaching independence. The system may detect the cognitive state of a child based on voice or cry pattern recognition, a time of day or night, scheduled activities, and social context, among other factors. The system may initiate actions to facilitate sleep in response to the cognitive factors. For example, the system may adjust lighting or push back a wakeup time. In another example, the system may use the cognitive analysis to teach children good sleeping habits by making recommendations to facilitate a good night's rest and encourage independence.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: November 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Maja Vukovic, Michael S. Gordon, Jinho Hwang, Ryan T. Gordon
  • Patent number: 11141560
    Abstract: Children who experience anxiety associated with novel situations react physically and emotionally in ways that make it challenging for the child, parents, educators, and providers to proceed with the intended goal of that novel situation. Anxiety in children can be reduced by introducing fun or distracting stimuli that act on specific neural pathways. The stimuli introduced can familiarize a child with the environment in which the procedure will take place and the equipment and people which the child will meet. In the healthcare setting, by using consistent stimuli, and by disrupting anxiety at one or more of a series of stages in which anxiety typically occurs, a reduction in needed anesthesia can be achieved, which is healthier for the child and reduces the costs associated with the medical or dental procedure.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: October 12, 2021
    Assignee: Calma Co LLC
    Inventors: Courtney A. Hill, Christie Traczyk, Adam Choe
  • Patent number: 11134844
    Abstract: Methods and systems are provided to monitor bio-signals associated with one or more physiological structures of a subject, process the bio-signals to determine neural information, determine a current state of the subject based on the neural information, determine feedback to be provided to the subject based on the current state and a desired state, and/or to provide the feedback to the subject in order to modify the subject's current state to the desired state. The neural information may include validated neural indices relating to dynamic regulation of the monitored physiological structures via identifiable neural pathways and/or neural metrics quantified from such neural indices.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: October 5, 2021
    Assignee: Polyvagal Science LLC
    Inventor: Stephen Porges
  • Patent number: 11052262
    Abstract: A method of affecting a biological, cellular or biochemical function or structure in a targeted subcortical location in a brain of a patient using a TRPMS apparatus placed on a head of the patient includes positioning two or more of a plurality of magnetic assemblies on locations of the head mount selected to stimulate the targeted subcortical location in the brain of the patient, and activating the plurality of magnetic assemblies at the selected locations to generate magnetic fluxes of a selected strength, frequency and duration directed into the brain of the patient, wherein the magnetic flux directed into the brain of the patient from each of the assemblies is operative to generate induced electric field in regions of the brain and the regions of induced electric fields generated by each of the plurality of magnetic assemblies converge in the targeted subcortical location and combine to a magnitude sufficient to affect the biological, cellular or biochemical function or structure in the targeted subcortic
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: July 6, 2021
    Assignee: SERAYA MEDICAL SYSTEMS LLC
    Inventor: Leeam Lowin
  • Patent number: 11049560
    Abstract: Methods, systems, and devices for a pulsed integrator and memory techniques are described. A first device may facilitate discharging a memory cell using at least one current pulse until a voltage associated with the memory cell reaches a reference voltage. The discharge time of the memory cell may be determined based at least in part on a duration of at least one current pulse. In some examples, a state of the memory cell may be determined based at least in part on a discharge time.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: June 29, 2021
    Assignee: Micron Technology, Inc.
    Inventors: Hernan A. Castro, Jeremy M. Hirst
  • Patent number: 10981016
    Abstract: A method of authorizing performance of transcranial magnetic stimulation on a subject using a head mount adapted to bear one or more magnetic assembly devices having unique identifiers. The method comprises connecting the one or more magnetic assembly devices to a control device, each magnetic assembly device being installed at a location on the head mount, receiving, at the control device, the identifiers of the connected magnetic assembly devices. determining whether the installed magnetic assembly devices are authorized for the treatment based on the received identifiers and treatment configuration information in a database, and energizing the connected magnetic assembly devices based on the determination of authorization.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: April 20, 2021
    Assignee: SERAYA MEDICAL SYSTEMS LLC
    Inventors: Leeam Lowin, David Leason
  • Patent number: 10893371
    Abstract: An apparatus for use in treating a neurological disorder of the auditory system, including a stimulus generation unit and a somatosensory stimulation unit. The stimulus generation unit operable to analyse an audio signal including a first component comprising a broadband or white noise component and a second component including a plurality of complex tone bursts, and generate a plurality of actuation signals representative of at least one of the first or second component of the audio signal and further to spectrally modify the audio signal to generate a binaural modified audio signal for delivery to a subject. The somatosensory stimulation unit includes: an array of stimulators to apply a somatosensory stimulation to the subject with the modified audio signal, and an input for receiving the plurality of actuation signals from the stimulus generation unit and directing individual actuation signals in a predetermined pattern to individual stimulators in the array.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: January 12, 2021
    Assignee: Neuromod Devices Limited
    Inventors: Stephen Hughes, Ross O'Neill, Brendan Conlon, Caroline Hamilton, Shona D'Arcy
  • Patent number: 10885152
    Abstract: An apparatus, system, and method for the measurement, aggregation and analysis of data collected using non-contact or minimally-contacting sensors provides quality of life parameters for individual subjects, particularly in the context of a controlled trial of interventions on human subjects (e.g., a clinical trial of a drug, or an evaluation of a consumer item such as a fragrance). In particular, non-contact or minimal-contact measurement of quality-of-life parameters such as sleep, stress, relaxation, drowsiness, temperature and emotional state of humans may be evaluated, together with automated sampling, storage, and transmission to a remote data analysis center. One component of the system is that the objective data is measured with as little disruption as possible to the normal behavior of the subject. The system can also support behavioral and pharmaceutical interventions aimed at improving quality of life.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: January 5, 2021
    Assignee: RESMED SENSOR TECHNOLOGIES LIMITED
    Inventors: Conor Heneghan, Conor Hanley, Niall Fox, Alberto Zaffaroni, Philip De Chazal
  • Patent number: 10863939
    Abstract: An emotion estimating method includes: acquiring first data and second data from the subject, the first data corresponding to physiology data, and the second data corresponding to one of physiology data different from the first data and non-physiology data; calculating a first value and a second value based on the acquired first data and second data, the first value indicating a degree of arousal of the subject and the second value indicating a degree of valence of the subject; estimating the emotion of the subject, by using the calculated first value and second value and based on a predetermined association of people's emotions with a degree of arousal and a degree of valence of the people, the predetermined association being pre-stored in a memory; and outputting information indicating the estimated emotion.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: December 15, 2020
    Assignee: PANASONIC INTELLECTUAL PROPERTY CORPORATION OF AMERICA
    Inventors: Nawatt Silawan, Koichi Kusukame, Shinji Uchida, Shinichi Shikii, Aki Yoneda, Tatsuo Itoh
  • Patent number: 10843006
    Abstract: Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a neural stimulation system that receives an indication of an ambient audio signal detected by a microphone. The system selects, from a profile, an audio signal including a fixed parameter and a variable parameter. The system sets the variable parameter to a first value. The system generates an output signal based on the fixed parameter and the first value, and provides the output signal to the speaker. The system measures a physiological condition of the subject, adjusts the variable parameter to a second value, generates a second output signal based on the fixed parameter and the second value of the variable parameter, and provides the output signal to the speaker to cause the speaker to provide modified sound to the subject.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: November 24, 2020
    Assignee: Cognito Therapeutics, Inc.
    Inventors: Zachary John Hambrecht Malchano, Martin Warren Williams
  • Patent number: 10835700
    Abstract: Various improvements are provided to breathing training, monitoring and/or assistance devices. A portable device is provided which optionally includes a gas canister, a feedback system for implementing pressure control, and a visual output for indicating adherence to a breathing exercise to the user. The pressure control may provide regulation of different pressures for inhalation and exhalation.
    Type: Grant
    Filed: September 18, 2016
    Date of Patent: November 17, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Manuela Lunz, Teunis Johannes Vink, Leendert Van Der Tempel, Mareike Klee, Lenneke Van Genugten, Neil Francis Joye, Franciscus Hendrikus Van Heesch, Edwin Van Rutten, Jeroen Herman Lammers, Gabriele Spina, Albertus Cornelis Den Brinker, Kevin Paul Warmerdam, Sander Kruitwagen, Andrew Mitchell, Denny Mathew, Achim Gerhard Rolf Koerber, Frank Bies
  • Patent number: 10806390
    Abstract: A system and method for health diagnostics and more specifically to an image-capture based system and method for detecting physiological state for a subject. The system provides a remote and non-invasive approach by which to detect physiological state with a high confidence. The system enables monitoring of hemoglobin concentration changes by optical imaging and related detection systems.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: October 20, 2020
    Assignee: NURALOGIX CORPORATION
    Inventors: Kang Lee, Pu Zheng
  • Patent number: 10799665
    Abstract: The present disclosure provides a system and a method for relaxation and cultivation of attention. The method comprising: detecting a non-respiratory bodily action of a first person; determining based on comparing the non-respiratory bodily action of the first person with at least one predetermined threshold, whether or not the first person is voluntarily attending on the non-respiratory bodily action at the present time; and generating feedback to be perceived by the first person through at least one response system if the first person is voluntarily attending on the non-respiratory bodily action at the present time.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: October 13, 2020
    Assignee: PAUSEABLE APS
    Inventor: Peng Cheng
  • Patent number: 10799667
    Abstract: Visual and auditory stimuli are provided to a patient to treat various neurological disorders or conditions and/or to provide improved mental or physical performance. The visual and auditory stimuli are provided by a wearable headset or sleep mask that may be comfortably worn by a user, such as in bed to induce sleep. The wearable headset or sleep mask includes, or works in cooperation with, sensors that determine the state of the user and modify the operation of the headset for treating various disorders or contentions.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: October 13, 2020
    Assignee: SANA HEALTH, INC.
    Inventor: Richard Hanbury
  • Patent number: 10792461
    Abstract: Introduced are methods and systems for an adjustable bed device configured to: gather biological signals associated with multiple users, such as heart rate, breathing rate, or temperature; analyze the gathered human biological signals; and heat or cool a bed based on the analysis.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: October 6, 2020
    Assignee: EIGHT SLEEP, INC.
    Inventors: Matteo Franceschetti, Massimo Andreasi Bassi
  • Patent number: 10764079
    Abstract: A method for security and/or automation systems is described. In one embodiment, the method may include receiving input regarding at least one home automation system operation profile. The method may further include receiving monitored sleep data of at least one user of a home automation system associated with the at least one home automation system operation profile. The method may further include comparing the received monitored sleep data with the received input regarding the at least one home automation system operation profile, and may include implementing the at least one home automation system operation profile based, at least in part, on the comparing.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: September 1, 2020
    Assignee: Vivint, Inc.
    Inventors: Matthew Mahar, Matthew J. Eyring, Clint Gordon-Carroll, Jeremy B. Warren, James Ellis Nye, Jefferson Lyman
  • Patent number: 10702154
    Abstract: Methods and systems are provided to monitor bio-signals associated with one or more physiological structures of a subject, process the bio-signals to determine neural information, determine a current state of the subject based on the neural information, determine feedback to be provided to the subject based on the current neural state and a desired neural state, and/or to provide the feedback to the subject in order to modify the subject's current neural state to the desired neural state. The neural information may include validated neural indices relating to dynamic regulation of the monitored physiological structures via identifiable neural pathways and/or neural metrics quantified from such neural indices.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: July 7, 2020
    Assignee: Polyvagal Science LLC
    Inventor: Stephen Porges
  • Patent number: 10695530
    Abstract: A subject's forehead, and underlying pre-frontal cortex may be cooled by positioning a pre-cooled heat transfer pack on the subject's forehead so that the heat transfer pack is in thermal communication with the subject's forehead, the temperature of the pre-cooled heat transfer pack being below 10° Celsius. Thermal communication between the subject's forehead and the heat transfer pack may be maintained for a period of time sufficient to cool the subject's pre-frontal cortex. Cooling of the pre-frontal cortex may slow the metabolic rate of the subject's pre-frontal cortex and/or induce an onset of sleep for the subject.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: June 30, 2020
    Assignee: Slumber Science LLC
    Inventor: Kevin Surace
  • Patent number: 10646723
    Abstract: The present invention is directed to a magnetic vestibular stimulation (MVS) system for rehabilitation of subjects with vestibular and balance disorders. The magnetic vestibular stimulation system includes a magnet and a cooling system. In some embodiments, the subject wears video goggles in order to stimulate the subject to orient to a virtual reality. The subject can lie, sit or stand in or near a strong magnetic field generated by the system. The magnetic field generated by the system stimulates the vestibular system to counteract the inherent imbalance created by a naturally-occurring vestibular disorder. Particularly important, the direction and amplitude of vestibular stimulation can be easily manipulated by altering the orientation and distance of the head relative to the magnetic field vector. Thus, MVS can be precisely tailored to a patient's specific pattern of vestibular disturbance.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: May 12, 2020
    Assignee: The Johns Hopkins University
    Inventors: Daniel H. Reich, Collin L. Broholm, David Zee, Dale Roberts, Michael C. Schubert, Jorge Otero-Millan, Bryan Ward
  • Patent number: 10646670
    Abstract: Systems slow breathing with positive pressure therapy. In embodiments, a current interim breathing rate target is set, and periodically magnitude of a variable pressure waveform scaled to the current interim breathing rate target is increased if breathing rate is greater than the interim rate target to lengthen breath duration. The magnitude of the pressure increase may be a function of the difference between the interim rate target and the breathing rate. The interim rate target may be reduced in response to slowing breathing rate. The waveform cycles, inhalation to exhalation, when airflow decreases to a cycle threshold. Different interim rate targets have different cycle threshold functions that allow easier cycling as the interim rate targets decrease. Similarly, the waveform triggers, exhalation to inhalation, when airflow increases to a trigger threshold. Different interim rate targets have different trigger threshold functions that allow easier triggering as the interim rate targets decrease.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: May 12, 2020
    Assignee: ResMed Pty Ltd
    Inventors: Dion Charles Chewe Martin, David John Bassin
  • Patent number: 10603462
    Abstract: The configurations herein are directed to a sleep trolley system for automation of sleep disruption. Such a unique system often includes a platform support system; a natural habitat chamber configured for an animal subject, wherein the natural habitat chamber is removeably disposed thereon the platform support system; an agitator disposed therein the natural habitat chamber, wherein the agitator is configured with a first magnetic component to provide magnetic coupling; a trolley affixed to the platform support system; wherein the trolley is configured with a second magnetic component, wherein the second magnetic component exerts a magnetic attraction force with the first magnetic component coupled to the agitator as disposed therein the natural habitat chamber; and a control system configured to move the trolley along a dimension of the platform support system so as to guide the agitator along a corresponding length of the natural habitat chamber via the magnetic attraction force.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: March 31, 2020
    Assignee: Washington State University
    Inventors: John Hoehn Harkness, Ryan Patrick Todd, Barbara A. Sorg
  • Patent number: 10603491
    Abstract: Detection and treatment of disordered breathing is disclosed, with treatment being primarily delivered using electrical stimulation of the diaphragm, either directly or by stimulating appropriate nerves.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: March 31, 2020
    Assignee: Respicardia, Inc.
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert, Antonis Panteleon
  • Patent number: 10542904
    Abstract: One aspect of the present disclosure relates to a system to facilitate at home neural monitoring. The system can include a wearable device and an external device. The wearable device can include an electrode configured to be placed behind a patient's ear to record an electroencephalogram (EEG) signal; an amplifier to amplify the EEG signal; a battery; and a wireless transmission system to transmit the amplified EEG signal. The external device can be configured to receive the amplified EEG signal and to perform analysis of the amplified EEG signal. In some instances, the external device can also provide neural stimulation (e.g., acoustic, visual, or electrical) to the wearable device in response to analysis of the amplified EEG signal.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: January 28, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Dominique M. Durand
  • Patent number: 10537254
    Abstract: A method for calculating blood pressure based on pulse return wave transmission time, and a blood pressure monitor have been provided. The method includes the following steps: S1: collecting and storing pulse waveform data at a fingertip; S2: processing said pulse waveform data to obtain a heart rate and parameters of a plurality of pulse periods, detecting time axis coordinates of a primary wave starting point SPL1 of a pulse wave and a growth point SPL2 of a return wave in each of said pulse periods, and calculating a corresponding pulse return wave transmission time RWTT: RWTT=SPL2?SPL1; S3: calculating the pulse return wave transmission time RWTT in each of said pulse periods to form a RWTT array; and S4: calculating systolic and diastolic pressures based on said RWTT array and the heart rate.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: January 21, 2020
    Assignee: HANGZHOU NANOCHAP ELECTRONICS CO., LTD.
    Inventor: Jiawei Yang
  • Patent number: 10540067
    Abstract: A breathing apparatus and system include a breathing apparatus having a display, an internal memory unit, and a processing unit, and optionally an interface for connecting at least an external memory unit to the apparatus; optionally an external memory unit connectable to the breathing apparatus via the interface; wherein the processing unit is in operative communication with the display, the internal memory unit, and/or the external memory unit when connected to the apparatus via the interface, and the processing unit is configured to provide on at least a portion of the display, a user selectable background stored on at least one of the internal and/or external memory unit, such as a background image, or a background color different than a factory default background color that is not selectable by a user.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: January 21, 2020
    Assignee: MAQUET CRITICAL CARE AB
    Inventors: Madlene Lindström, Anette Sunna, Helena Stone
  • Patent number: 10537703
    Abstract: Methods and apparatuses for improving sleep by transdermal electrical stimulation (TES). In general, described herein are methods for applying TES to a subject, and particularly the subject's head (e.g., temple/forehead region) and/or neck with an TES waveform adapted to improve sleep, including reducing sleep onset (falling to sleep) more quickly and/or lengthening the duration of sleep. TES waveform(s) particularly well suited to enhancing sleep are also described herein.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: January 21, 2020
    Assignee: Thync Global, Inc.
    Inventors: William J. Tyler, Alyssa M. Boasso, Hailey M. Mortimore, Sumon K. Pal, Jonathan Charlesworth
  • Patent number: 10512783
    Abstract: Systems and related methods for controlling delivery of a stimulus to a pinna of a subject with a stimulator worn on the pinna are described. A wearable stimulation device includes a mechanical, electrical, or other type of stimulator secured to a pinna of a subject. A personal computing device in communication with the wearable stimulation device controls delivery of stimuli and other aspects of operation of the device. The personal computing device presents various types of information relating to operation and control of the device to a user of the wearable stimulation device. In some aspects recommendations regarding neural stimuli and other stimuli or experiences to be delivered in association with the neural stimuli are provided via a computing system in communication with the personal computing device or the wearable stimulation device.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 24, 2019
    Assignee: eQuility LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Stephen L. Malaska, Nathan P. Myhrvold, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 10456579
    Abstract: An electrotherapeutic system for treating a visual disease is disclosed. The system includes a signal generator configured to generate a treatment waveform comprising a series of current pulses. Preferably, the current pulses have a peak current amplitude of 200 microamps or less. The system also includes a headset applicator comprising a headband and a headset. The headset has a magnetic slot configured to be mounted to a magnetic mount of the headband. The headset includes left and right eyecup electrodes each of which has a contact surface that is positioned for contact with a skin surface within left and right eye regions, respectively. Preferably, the contact surface of each of the left and right eyecup electrodes comprises an upper contact pad and a lower contact pad that have a total area in the range of about 1.10 cm2 to about 1.80 cm2. The headset is connectable to the signal generator and configured to deliver the treatment waveform to one or both of the left and right electrodes.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: October 29, 2019
    Assignee: Nova Oculus Canada Manufacturing ULC
    Inventor: Alfonso Salazar
  • Patent number: 10456082
    Abstract: A method, apparatus and computer program, in which a body of a wearable apparatus is maintained maintaining by a link in place at a given part of skin of the user. A sensor platform is movably supported sandwiched between the body and the skin and supported by the body movably with relation to the body towards and away of the skin, when the apparatus is worn by the user. A sensor is supported by the sensor platform. The sensor produces sensor signals corresponding to a property of the skin or underlying matter. The position of the sensor platform is adjusted by an actuator with relation to the skin.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: October 29, 2019
    Assignee: Nokia Technologies Oy
    Inventors: Matti Kosonen, Harri Lasarov
  • Patent number: 10453227
    Abstract: A mass spectrometry data processing apparatus having a function of displaying a plurality of MSn spectra in an arranged manner is allowed to display these MSn spectra in a state where a user can easily grasp presence or absence of a common neutral loss. A mass spectrometry data processing apparatus 20 that displays, on a display screen, an MSn spectrum resulting from mass spectrometric analysis of n?1 stage dissociation, where n is integer of two or more, of an ion, includes: a precursor ion identifying section 32 configured to identify, for each of a plurality of MSn spectra, a mass-to-charge ratios m/z of a precursor ion from which the MSn spectra are obtained; and a spectrum aligning section 33 configure to display the MSn spectra on the display screen in a vertically arranged manner such that positions of the mass-to-charge ratios m/z of the respective precursor ions are located at a same horizontal position of the display screen.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: October 22, 2019
    Assignee: SHIMADZU CORPORATION
    Inventors: Hiroyuki Yasuda, Yoshikatsu Umemura, Tetsuya Kageyama
  • Patent number: 10426904
    Abstract: An anesthesia system includes a volume reflector, a breathing circuit, a processing unit, and a display operatively connected to the processing unit. The processing unit is configured to provide a status indicator on the display for gas in the volume reflector, the status indicator including a graphical representation of an extent of a driving gas of the volume reflector and/or a patient gas in the volume reflector, and/or a flow of gas and a direction of the flow in the volume reflector, and/or a waste gas flow out of the volume reflector relative a fresh gas flow in the system, and/or a re-breathing fraction (RBF), and/or a balance between the fresh gas flow and patient uptake and/or leakage of gas from the breathing circuit.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: October 1, 2019
    Assignee: Maquet Critical Care AB
    Inventors: Stefan Broborg, Jacob Jansson, Hans Bocké
  • Patent number: 10420912
    Abstract: A system for influencing the senses of a person in a room for measuring and/or influencing physiological parameters of the person is provided. The person is substantially stationary and lying in the room during the measurement and/or influencing. The system includes a sound insulating apparatus for screening off acoustically active devices with respect to the person. The acoustically active devices serve for measuring and/or influencing the physiological parameters in the room, and an optical display apparatus for offering optical stimuli and/or signals for the person in the field of view of the person.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: September 24, 2019
    Assignee: Graft Gesellschaft von Architekten mbH
    Inventors: Alawi Lütz, Claudia Spies, Thomas Willemeit, Annette Finke
  • Patent number: 10398902
    Abstract: Systems and related methods for controlling delivery of a stimulus to a pinna of a subject with a stimulator worn on the pinna are described. A wearable stimulation device includes a mechanical, electrical, or other type of stimulator secured to a pinna of a subject. A personal computing device in communication with the wearable stimulation device controls delivery of stimuli and other aspects of operation of the device. The personal computing device also controls delivery of a sound signal (for example, music) to the user of the stimulation device in association with the neural stimulus. In some aspects recommendations regarding neural stimuli and other stimuli or experiences to be delivered in association with the neural stimuli are provided via a computing system in communication with the personal computing device or the wearable stimulation device.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: September 3, 2019
    Assignee: eQuility LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Stephen L. Malaska, Nathan P. Myhrvold, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 10384070
    Abstract: The present invention provides for eyeglasses to deliver light therapy to the wearer. The eyeglass lenses or frames feature an embedded light source in logical and electrical communication with power, sensors, processors, and other components contained within the eyeglasses.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: August 20, 2019
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall B. Pugh, William Chester Neeley, Robertson Towart, Mario Peeters, Wilhelmus Drinkenburg, Aleksander Miletic
  • Patent number: 10368797
    Abstract: A system for monitoring sleep efficiency includes a measuring device and a data processing device. The measuring device is for measuring body temperature of a subject and for outputting temperature data associated with the body temperature. The data processing device receives the temperature data, and is programmed to process the temperature data so as to determine sleep efficiency. The processing of the temperature data includes constructing a curve of the body temperature over asleep episode, finding a saddle point of the curve occurring for a first time, treating a time instance at which the saddle point occurs as a sleep-onset time point at which the subject falls asleep, and determining the sleep efficiency according to the sleep-onset time point.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: August 6, 2019
    Inventor: Tsung-Cheng Huang
  • Patent number: 10357663
    Abstract: Light therapy is provided to a subject using a system and/or method. The light therapy includes the administration of electromagnetic radiation to the eyeball of the subject underneath the eyelid of the subject while the eyelid of the subject is closed (e.g., as the subject sleeps). The light therapy algorithm may be designed to impact melatonin and/or serotonin levels within the body of the subject in a therapeutically beneficial manner. For example, the light therapy algorithm may be designed to impact melatonin and/or serotonin levels to treat one or more of a sleep and/or mood disorder (e.g., seasonal affective disorder, non-seasonal depression, Circadian rhythm disruption), or other disorders treatable with control over melatonin and/or serotonin levels in the body.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: July 23, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Michael Edward Colbaugh, Timothy A. Nathan
  • Patent number: 10328263
    Abstract: In a patient suffering from neural impairment, stimulation is provided to sensory surfaces of the face and/or neck, or more generally to areas of the body that stimulate the trigeminal nerve, while performing an activity intended to stimulate a brain function to be rehabilitated. The simulation may then be continued after the performance of the activity has ceased. It has been found that the patient's performance of the activity is then improved after stimulation has ceased. Moreover, it tends to improve to a greater extent, and/or for a longer time, when the post-activity stimulation is applied, as compared to when post activity stimulation is not applied.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: June 25, 2019
    Inventors: Yuri P. Danilov, Mitchell E. Tyler, Kurt A. Kaczmarek
  • Patent number: 10293177
    Abstract: Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a neural stimulation system that receives an indication of an ambient audio signal detected by a microphone. The system selects, from a profile, an audio signal including a fixed parameter and a variable parameter. The system sets the variable parameter to a first value. The system generates an output signal based on the fixed parameter and the first value, and provides the output signal to the speaker. The system measures a physiological condition of the subject, adjusts the variable parameter to a second value, generates a second output signal based on the fixed parameter and the second value of the variable parameter, and provides the output signal to the speaker to cause the speaker to provide modified sound to the subject.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 21, 2019
    Assignee: COGNITO THERAPEUTICS, INC.
    Inventors: Zachary John Hambrecht Malchano, Martin Warren Williams
  • Patent number: 10293163
    Abstract: A method to provide non-invasive neurostimulation to enhance a subject's proficiency in an exercise includes: (a) engaging a subject in a physical or mental exercise, the subject having no cognitive, physical or emotional impairment; (b) providing intraoral cutaneous stimulation of at least one of the subject's trigeminal nerve, facial nerve or hypoglossal nerve by delivering electrical pulses to one or more stimulators situated within the subject's mouth, the delivery of electrical pulses being (i) contemporaneously with and independent of the subject's engagement in the exercise, and (ii) independent of the subject's surrounding environment; and (c) repeating steps (a) and (b) on a periodic basis.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: May 21, 2019
    Inventors: Yuri P. Danilov, Mitchell E. Tyler, Kurt A. Kaczmarek
  • Patent number: 10292639
    Abstract: There is provided an information processing device including: a sleep environment controlling unit configured to, when exerting control of, on the basis of a result of forecast of a transition of a depth of sleep of a user at least in a period from a first time to a second time, a sleeping environment of the user such that the depth of sleep at the second time falls below a first depth-of-sleep threshold value estimated as an upper limit of a first depth-of-sleep region in which the user is likely to awake, decide a temporal pattern of the control in the period from the first time to the second time in accordance with a temporal pattern of the transition.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: May 21, 2019
    Assignee: SONY CORPORATION
    Inventor: Yasushi Tsuruta
  • Patent number: 10286555
    Abstract: A method for inducing the feeling of a presence (FoP) in a subject by using a master-slave robotic system, the method including the steps of altering a visual perception of a surrounding environment of the subject, connecting the subject with a robotic master device so that the subject can move, move on or manipulate the robotic master device, connecting the subject with a robotic slave device, making the subject move, move on or manipulate the robotic master device so that the subject is directly or indirectly touched by the robotic slave device according to a movement of the robotic master device, wherein the robotic master device and the robotic slave device are operatively connected so that the subject receives at least one of spatially and temporally conflicting sensorimotor stimulation.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 14, 2019
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Giulio Rognini, Olaf Blanke, Masayuki Hara
  • Patent number: 10288786
    Abstract: Method, device (100) and system (200) for detection and quantification of the variation of eye damage caused by the blue and violet light of the visible spectrum comprising the steps of detecting the incident radiation on an individual's visual system; calculating the incident radiation within the range between 380 and 500 nm; establishing at least one threshold of incident radiation within said range; detecting if at least one threshold established for said range has been exceeded; warning of the excess of at least one threshold; measuring the exposure time to incident radiation; and inferring in the different ocular structures of an individual the effect of incident radiation and warning of such effect.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: May 14, 2019
    Assignees: UNIVERSIDAD COMPLUTENSE DE MADRID, CRAMBO, S.A.
    Inventors: Celia Sanchez Ramos, Nilo Garcia Manchado
  • Patent number: 10157349
    Abstract: A computer-implemented method of automating inductive bias selection includes a computer receiving a plurality of examples, each example providing a plurality of feature-value pairs. The computer constructs an inductive bias dataset which correlates each respective example in the plurality of examples with numerical indications of training quality. The numerical indications of training quality for each respective example are generated by creating a plurality of models, with each model corresponding to a distinct set of inductive biases. The training quality for each respective model is evaluated when applied to the respective example. The computer uses the inductive bias dataset to select a plurality of inductive biases for application to one or more new datasets.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: December 18, 2018
    Assignee: PTC Inc.
    Inventors: Ryan Todd Caplan, Bruce F. Katz, Joseph John Pizonka
  • Patent number: 10105066
    Abstract: Methods, apparatuses and systems for controlling an alarm are set forth herein for reminding a user with assurance of sleep quality. The method includes receiving sleep information, determining a sleep status, determining whether duration of the sleep status reaches a pre-determined duration threshold, and based on a determination that the duration of the sleep status reaches the pre-determined duration threshold, outputting alarming information.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: October 23, 2018
    Assignee: Anhui Huami Information Technology Co.,Ltd.
    Inventors: Haocheng Wu, Hui Wang
  • Patent number: 9999744
    Abstract: A user monitoring device system includes a user monitoring device with a microphone and sensors to determine air quality, sound level/quality, light quality and ambient temperature near the user. A movement detection device detects a user's movement information. The movement detection device and the monitoring system assist to determine user sleep information and sleep behavior information. The microphone records user movement sounds detected by the movement detection device. The movement detection device is configured to cause the microphone to stop recording user movement sounds when the movement sounds are not directed to a sleep related parameter. In response to determining user sleep information or sleep behavior information the system is used for treatment of sleep or psychiatric disorders.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: June 19, 2018
    Assignee: FITBIT, INC.
    Inventor: James Proud
  • Patent number: 9997083
    Abstract: One embodiment provides a system comprising at least one learner application module for receiving feedback data from at least one user via at least one electronic device, about information presented to the users by a presenter. The system further comprises at least one sensor for capturing contextual data associated with the users. The system further comprises a recommendation provider for collecting feedback data and contextual data from each learner application module and each sensor, respectively. The recommendation provider determines at least one personalized recommendation for each user based on the collected data and the presented information.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: June 12, 2018
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Saeed Abbasi Moghaddam, Emmanuel M. Tapia
  • Patent number: 9981107
    Abstract: Introduced are methods and systems for: gathering human biological signals, such as heart rate, breathing rate, or temperature; analyzing the gathered human biological signals; and controlling home appliances based on the analysis.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: May 29, 2018
    Assignee: Eight Sleep Inc.
    Inventors: Matteo Franceschetti, Massimo Andreasi Bassi
  • Patent number: 9962104
    Abstract: A stress-measuring device (10) and method determines a level (15) of stress of a user (1), in particular long-term stress. The stress-measuring device (10) includes an input interface (12) for receiving a skin conductance signal (11) indicating the skin conductance of the user (1), the skin conductance signal (11) over time forming skin conductance trace data (13). The stress-measuring device (10) further includes a processing unit (14) for processing the skin conductance trace data (13). The processing unit (14) determines, over at least a portion of the skin conductance trace data (13), values of a rise time (tr) between at least two different points of the skin conductance trace data (13), a frequency distribution of the rise time (tr) values, and the level (15) of stress of the user (1) based on the determined frequency distribution.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: May 8, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Jan Johannes Gerardus De Vries, Martin Ouwerkerk