Abstract: Methods for controlling brain activity in a subject are described herein. An example method can include delivering a stimulus to the subject, wherein the stimulus induces neural activity in the subjects brain and modulates expression of at least one soluble mediator of cellular activity (such as, for example, a cytokine, chemokine, and/or growth factor) within the subject, and the stimulus is delivered to the subject for less than one hour.

Abstract: Wearable devices can be used to provide therapy to users and/or to monitor various physiological parameters of the user. In some cases, therapy can be triggered automatically based on the monitored physiological parameters reaching or exceeding predefined thresholds.

Abstract: In one aspect, a method of determining a location of a user within an indoor space, includes emitting a radiofrequency signal into the indoor space, receiving backscattered training radiofrequency signals, including multipath, for at least one location within the indoor space, converting the received training signals into a point cloud for each location of the at least one location, assigning a signature for each location based on the point cloud for each location, receiving additional radiofrequency signals, including multipath, converting the additional radiofrequency signals into an additional point cloud, and determining a location of the user by comparing the additional point cloud to the assigned signatures.

Abstract: A sterile barrier system package comprising a tray, a lidding film and a unique printed or molded SBS Code for communicating and tracking the SBS to its specific intended usability through activating a digital experience.

Abstract: The present disclosure discloses a method, device, apparatus, and storage medium for sleep monitoring. The method includes: monitoring physical sign information of a user in response to receiving a monitoring command; determining sleep quality information of the user according to the physical sign information of the user, wherein the physical sign information comprises at least breathing information.

Abstract: A vibration signal-based smartwatch authentication method includes generating incremental vibration signals using a vibration motor in a smartwatch; performing frequency band-based hierarchical endpoint segmentation to obtain vibration signals at a plurality of frequency bands; extracting frequency-domain features for the vibration signals at the plurality of frequency bands; training a dynamic time warping model by taking the vibration signals at the plurality of frequency bands as a training data set, training a nearest neighbor model by taking the extracted frequency-domain features as training data; collecting to-be-authenticated vibration signals which are processed to serve as test data signals; discriminating similarities between the test data signals and corresponding training data signals through the dynamic time warping model, giving a classification result through the nearest neighbor model, performing weighted calculation on a discrimination result of the dynamic time warping model and a discrimin

Abstract: An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone whereby the ferric element force can be adjusted by a force delivery element.

Abstract: A method may include presenting, on a display of an infusion device, a first patient parameter and a second patient parameter. The infusion device may receive a first entry, which may include a first value of the first patient parameter. The infusion device may determine a default value of the second patient parameter based on the entered first value of the first patient parameter. The infusion device may present the determined default value of the second patient parameter. The infusion device may receive a second entry, which includes a second value of the second patient parameter. The second value may be an adjustment of the default value of the second patient parameter that is an accurate representation of the second patient parameter. Related methods and articles of manufacture, including apparatuses and computer program products, are also disclosed.

Abstract: System and methods of a mobile application to remotely monitor residents with device-free sensing of human motion over Wi-Fi is provided. A detailed behavioral analysis of various functions related to the sleep and activity of the subject has been provided. The Remote Care Application (RCA) is a mobile application on several platforms that displays the results of all the analysis and behavioral patterns obtained from the motion from the subject. The system relies on existing wireless communication signals and machine learning techniques in order to automatically detect the motion of the subject, sleep analysis of the subject, activity analysis of the subject.

Abstract: Various examples of methods and systems are provided for real-time signal processing. In one example, a method for processing data to select a pattern includes receiving data via a sensor, evaluating the data including waveforms over a time domain, averaging the waveforms to obtain a mean waveform, selecting a pattern based on the mean waveform, and generating a notification regarding the selected pattern. The pattern can include a start time, a hold time, and an end time. In another example, a system includes one or more sensors that detect the data and a mobile platform that evaluates the data, averages the waveforms to obtain the mean waveform and selects a pattern based on the mean waveform. A user interface can be used to communicate the notification regarding the selected pattern. The patterns can include breathing patterns, which can be used to reduce stress in a subject being monitored by the sensor.

Abstract: An apparatus and method for removing high-frequency radio frequency interference are disclosed.

Abstract: Real time mirroring of dominant brain frequencies through the use of two types of stimuli is provided. Through devices and methods that simultaneously look for asymmetries and in real time, one can create real time variable sequences of acoustic and electric stimuli, and then one can effectively and efficiently support the brain to balance its activity between corresponding right and left lobes without one's mindful attention.

Abstract: The present disclosure generally relates to user interfaces for breathing sequences. In some examples, a device displays a configuration user interface that comprises a prompt to select a number of cycles of a breathing sequence, adjusts the number of cycles of the breathing sequence to the selected number of cycles in response to selection, and initiates a breathing phase of the breathing sequence. In some examples, the device displays and fluctuates a progress indicator in accordance with the selected number of cycles. In some examples, a device detects a time associated with a first breathing sequence, generates a prompting criteria based on a predetermined prompting frequency and the detected time, determines if the prompting criteria has been met, displays a prompt to initiate a second breathing sequence, wherein the prompt comprises a first affordance, and displays a second breathing sequence user interface in response to selection of the first affordance.

Abstract: Systems methods are described for modifying sleep patterns based on biofeedback. The method may include identifying a target sleep pattern from a plurality of candidate sleep patterns, receiving biofeedback information from a user, identifying a stimulus pattern based on the target sleep pattern and the biofeedback information, and providing at least one stimulus to the user based on the stimulus pattern.

Abstract: A method of estimating a body temperature of an individual based on physiological data including a heart rate received from at least one sensor 510 and received environmental data. The physiological data and the environmental data are inputted into a model present on a processor 520. The model generates an estimated body temperature and an estimated physiological condition based on the inputs. The processor 520 compares the estimated physiological condition to a measured physiological condition in the physiological data. A controller 530 modifies at least one parameter in the model when the difference between the estimated physiological condition and the measured physiological condition is above a threshold.

Abstract: Systems slow breathing with positive pressure therapy. In embodiments, a current interim breathing rate target is set, and periodically magnitude of a variable pressure waveform scaled to the current interim breathing rate target is increased if breathing rate is greater than the interim rate target to lengthen breath duration. The magnitude of the pressure increase may be a function of the difference between the interim rate target and the breathing rate. The interim rate target may be reduced in response to slowing breathing rate. The waveform cycles, inhalation to exhalation, when airflow decreases to a cycle threshold. Different interim rate targets have different cycle threshold functions that allow easier cycling as the interim rate targets decrease. Similarly, the waveform triggers, exhalation to inhalation, when airflow increases to a trigger threshold. Different interim rate targets have different trigger threshold functions that allow easier triggering as the interim rate targets decrease.

Abstract: A sleep assessment system includes a blood flow measurement unit and a assessment unit. The blood flow measurement unit acquires first information related to the blood flow of the user. The assessment unit determines the sleep stage of the user based on the first biological information.

Abstract: Wearable devices for providing therapy to a patient may include disposable or reusable treatment pads. The treatment pads may include electrodes and are configured to apply energy to various regions around the head and eyes. The treatment pads may provide therapy when the eyes are open or closed. The wearable device may include a battery and/or control circuitry for issuing therapy pulses through the electrodes.

Abstract: A bed includes components to control temperature of a sleep surface, for example based on time and historical usage patterns by a user. In some embodiments the temperature of the sleep surface is controlled based on information indicating a sleep state of the user. In some embodiments the temperature is dynamically adjusted so to achieve particular sleep states and/or sleep patterns for the user. In some embodiments the temperature and timing of temperature adjustments is iteratively adjusted over multiple sleep sessions so to achieve improvements in sleep states and/or sleep quality for the user.

Abstract: A system and method for health diagnostics and more specifically to an image-capture based system and method for detecting physiological state for a subject. The system provides a remote and non-invasive approach by which to detect physiological state with a high confidence. The system enables monitoring of hemoglobin concentration changes by optical imaging and related detection systems.

Abstract: A system and a method of turnkey neurological solution to provide a variety of stimulations including photo-stimulation, binaural stimulation, and electro-acupuncture in wearable form, such as in glasses. Light may be generated from at least one light source powered by integrated photovoltaic cells and amplified light may be sent to a predetermined direction through the at least one angularly oriented optical window in which one face is covered by an optical film or coating. Also, the system and method may provide that, as an optical window is fabricated, photovoltaics may be fused directly to faces of the optical window for absorption of ambient light energy, and a light source may be fused into grooves on the edge of the optical window, with nanoelectrodes attached for electrical connections to controllers inserted in a housing. It may also be contemplated to provide binaural stimulation and electro-acupuncture effectors on the wearable device.

Abstract: A method of modulating a brain activity of a mammal is achieved by subjecting the mammal to repetitive transcranial magnetic stimulation (rTMS) with an rTMS apparatus at variable pulse intervals for a time sufficient to modulate said brain activity. Improvement in a physiological condition or a clinical condition is achieved. Conditions to be treated include but are not limited to PTSD, autism spectrum disorder and Alzheimer's disease. Wavelet transform analysis is used to determine the variable pulse intervals employed.

Abstract: An orthotic obstructive sleep apnea treatment device is provided that includes a hyoid bone attachment element disposed to attach a ferric element to a hyoid bone whereby the ferric element force can be adjusted by a force delivery element.

Abstract: An interactive multi-purpose interactive cognitive platform is provided that uses image-based interactivities and may use enriched visual stimuli for diagnoses, treatment, and to evaluate and assess the progress and/or treatment of cognitive diseases and/or conditions with cognitive impacts. The platform may be used for performance enhancement training. The platform may include a graphical user interface. The platform is designed to cooperatively engage multiple cognitive domains using interactivities-embedded assessments. The images and image sets may involve the application of Gestalt principles for assessments and may be personalized address individual user preferences. The multi-purpose interactive cognitive platform may be used to produce diagnostics and/or treatment plans for specific cognitive conditions and diseases with a cognitive component.

Abstract: An energy optimization system for a load of perishable goods in temperature controlled storage, wherein a thermal profile of the load is developed, which is then used, in connection with temperature readings of the air and goods to simulate an expected temperature of the goods over an absolute or relative time duration at one or more set points. The simulation allows an optimal energy efficient set point to be determined, which may then be used to make the HVAC unit of the temperature controlled storage zone more energy efficient.

Abstract: Systems and methods to facilitate sleep are described. In on example, a cognitive alarm clock system for children learns sleep patterns and activities towards recommending sleep schedules and teaching independence. The system may detect the cognitive state of a child based on voice or cry pattern recognition, a time of day or night, scheduled activities, and social context, among other factors. The system may initiate actions to facilitate sleep in response to the cognitive factors. For example, the system may adjust lighting or push back a wakeup time. In another example, the system may use the cognitive analysis to teach children good sleeping habits by making recommendations to facilitate a good night's rest and encourage independence.

Abstract: Systems and methods to facilitate sleep are described. In on example, a cognitive alarm clock system for children learns sleep patterns and activities towards recommending sleep schedules and teaching independence. The system may detect the cognitive state of a child based on voice or cry pattern recognition, a time of day or night, scheduled activities, and social context, among other factors. The system may initiate actions to facilitate sleep in response to the cognitive factors. For example, the system may adjust lighting or push back a wakeup time. In another example, the system may use the cognitive analysis to teach children good sleeping habits by making recommendations to facilitate a good night's rest and encourage independence.

Abstract: Children who experience anxiety associated with novel situations react physically and emotionally in ways that make it challenging for the child, parents, educators, and providers to proceed with the intended goal of that novel situation. Anxiety in children can be reduced by introducing fun or distracting stimuli that act on specific neural pathways. The stimuli introduced can familiarize a child with the environment in which the procedure will take place and the equipment and people which the child will meet. In the healthcare setting, by using consistent stimuli, and by disrupting anxiety at one or more of a series of stages in which anxiety typically occurs, a reduction in needed anesthesia can be achieved, which is healthier for the child and reduces the costs associated with the medical or dental procedure.

Abstract: Methods and systems are provided to monitor bio-signals associated with one or more physiological structures of a subject, process the bio-signals to determine neural information, determine a current state of the subject based on the neural information, determine feedback to be provided to the subject based on the current state and a desired state, and/or to provide the feedback to the subject in order to modify the subject's current state to the desired state. The neural information may include validated neural indices relating to dynamic regulation of the monitored physiological structures via identifiable neural pathways and/or neural metrics quantified from such neural indices.

Abstract: A method of affecting a biological, cellular or biochemical function or structure in a targeted subcortical location in a brain of a patient using a TRPMS apparatus placed on a head of the patient includes positioning two or more of a plurality of magnetic assemblies on locations of the head mount selected to stimulate the targeted subcortical location in the brain of the patient, and activating the plurality of magnetic assemblies at the selected locations to generate magnetic fluxes of a selected strength, frequency and duration directed into the brain of the patient, wherein the magnetic flux directed into the brain of the patient from each of the assemblies is operative to generate induced electric field in regions of the brain and the regions of induced electric fields generated by each of the plurality of magnetic assemblies converge in the targeted subcortical location and combine to a magnitude sufficient to affect the biological, cellular or biochemical function or structure in the targeted subcortic

Abstract: Methods, systems, and devices for a pulsed integrator and memory techniques are described. A first device may facilitate discharging a memory cell using at least one current pulse until a voltage associated with the memory cell reaches a reference voltage. The discharge time of the memory cell may be determined based at least in part on a duration of at least one current pulse. In some examples, a state of the memory cell may be determined based at least in part on a discharge time.

Abstract: A method of authorizing performance of transcranial magnetic stimulation on a subject using a head mount adapted to bear one or more magnetic assembly devices having unique identifiers. The method comprises connecting the one or more magnetic assembly devices to a control device, each magnetic assembly device being installed at a location on the head mount, receiving, at the control device, the identifiers of the connected magnetic assembly devices. determining whether the installed magnetic assembly devices are authorized for the treatment based on the received identifiers and treatment configuration information in a database, and energizing the connected magnetic assembly devices based on the determination of authorization.

Abstract: An apparatus for use in treating a neurological disorder of the auditory system, including a stimulus generation unit and a somatosensory stimulation unit. The stimulus generation unit operable to analyse an audio signal including a first component comprising a broadband or white noise component and a second component including a plurality of complex tone bursts, and generate a plurality of actuation signals representative of at least one of the first or second component of the audio signal and further to spectrally modify the audio signal to generate a binaural modified audio signal for delivery to a subject. The somatosensory stimulation unit includes: an array of stimulators to apply a somatosensory stimulation to the subject with the modified audio signal, and an input for receiving the plurality of actuation signals from the stimulus generation unit and directing individual actuation signals in a predetermined pattern to individual stimulators in the array.

Abstract: An apparatus, system, and method for the measurement, aggregation and analysis of data collected using non-contact or minimally-contacting sensors provides quality of life parameters for individual subjects, particularly in the context of a controlled trial of interventions on human subjects (e.g., a clinical trial of a drug, or an evaluation of a consumer item such as a fragrance). In particular, non-contact or minimal-contact measurement of quality-of-life parameters such as sleep, stress, relaxation, drowsiness, temperature and emotional state of humans may be evaluated, together with automated sampling, storage, and transmission to a remote data analysis center. One component of the system is that the objective data is measured with as little disruption as possible to the normal behavior of the subject. The system can also support behavioral and pharmaceutical interventions aimed at improving quality of life.

Abstract: An emotion estimating method includes: acquiring first data and second data from the subject, the first data corresponding to physiology data, and the second data corresponding to one of physiology data different from the first data and non-physiology data; calculating a first value and a second value based on the acquired first data and second data, the first value indicating a degree of arousal of the subject and the second value indicating a degree of valence of the subject; estimating the emotion of the subject, by using the calculated first value and second value and based on a predetermined association of people's emotions with a degree of arousal and a degree of valence of the people, the predetermined association being pre-stored in a memory; and outputting information indicating the estimated emotion.

Abstract: Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a neural stimulation system that receives an indication of an ambient audio signal detected by a microphone. The system selects, from a profile, an audio signal including a fixed parameter and a variable parameter. The system sets the variable parameter to a first value. The system generates an output signal based on the fixed parameter and the first value, and provides the output signal to the speaker. The system measures a physiological condition of the subject, adjusts the variable parameter to a second value, generates a second output signal based on the fixed parameter and the second value of the variable parameter, and provides the output signal to the speaker to cause the speaker to provide modified sound to the subject.

Abstract: Various improvements are provided to breathing training, monitoring and/or assistance devices. A portable device is provided which optionally includes a gas canister, a feedback system for implementing pressure control, and a visual output for indicating adherence to a breathing exercise to the user. The pressure control may provide regulation of different pressures for inhalation and exhalation.

Abstract: A system and method for health diagnostics and more specifically to an image-capture based system and method for detecting physiological state for a subject. The system provides a remote and non-invasive approach by which to detect physiological state with a high confidence. The system enables monitoring of hemoglobin concentration changes by optical imaging and related detection systems.

Abstract: The present disclosure provides a system and a method for relaxation and cultivation of attention. The method comprising: detecting a non-respiratory bodily action of a first person; determining based on comparing the non-respiratory bodily action of the first person with at least one predetermined threshold, whether or not the first person is voluntarily attending on the non-respiratory bodily action at the present time; and generating feedback to be perceived by the first person through at least one response system if the first person is voluntarily attending on the non-respiratory bodily action at the present time.

Abstract: Visual and auditory stimuli are provided to a patient to treat various neurological disorders or conditions and/or to provide improved mental or physical performance. The visual and auditory stimuli are provided by a wearable headset or sleep mask that may be comfortably worn by a user, such as in bed to induce sleep. The wearable headset or sleep mask includes, or works in cooperation with, sensors that determine the state of the user and modify the operation of the headset for treating various disorders or contentions.

Abstract: Introduced are methods and systems for an adjustable bed device configured to: gather biological signals associated with multiple users, such as heart rate, breathing rate, or temperature; analyze the gathered human biological signals; and heat or cool a bed based on the analysis.

Abstract: A method for security and/or automation systems is described. In one embodiment, the method may include receiving input regarding at least one home automation system operation profile. The method may further include receiving monitored sleep data of at least one user of a home automation system associated with the at least one home automation system operation profile. The method may further include comparing the received monitored sleep data with the received input regarding the at least one home automation system operation profile, and may include implementing the at least one home automation system operation profile based, at least in part, on the comparing.

Abstract: Methods and systems are provided to monitor bio-signals associated with one or more physiological structures of a subject, process the bio-signals to determine neural information, determine a current state of the subject based on the neural information, determine feedback to be provided to the subject based on the current neural state and a desired neural state, and/or to provide the feedback to the subject in order to modify the subject's current neural state to the desired neural state. The neural information may include validated neural indices relating to dynamic regulation of the monitored physiological structures via identifiable neural pathways and/or neural metrics quantified from such neural indices.

Abstract: A subject's forehead, and underlying pre-frontal cortex may be cooled by positioning a pre-cooled heat transfer pack on the subject's forehead so that the heat transfer pack is in thermal communication with the subject's forehead, the temperature of the pre-cooled heat transfer pack being below 10° Celsius. Thermal communication between the subject's forehead and the heat transfer pack may be maintained for a period of time sufficient to cool the subject's pre-frontal cortex. Cooling of the pre-frontal cortex may slow the metabolic rate of the subject's pre-frontal cortex and/or induce an onset of sleep for the subject.

Abstract: The present invention is directed to a magnetic vestibular stimulation (MVS) system for rehabilitation of subjects with vestibular and balance disorders. The magnetic vestibular stimulation system includes a magnet and a cooling system. In some embodiments, the subject wears video goggles in order to stimulate the subject to orient to a virtual reality. The subject can lie, sit or stand in or near a strong magnetic field generated by the system. The magnetic field generated by the system stimulates the vestibular system to counteract the inherent imbalance created by a naturally-occurring vestibular disorder. Particularly important, the direction and amplitude of vestibular stimulation can be easily manipulated by altering the orientation and distance of the head relative to the magnetic field vector. Thus, MVS can be precisely tailored to a patient's specific pattern of vestibular disturbance.

Abstract: Systems slow breathing with positive pressure therapy. In embodiments, a current interim breathing rate target is set, and periodically magnitude of a variable pressure waveform scaled to the current interim breathing rate target is increased if breathing rate is greater than the interim rate target to lengthen breath duration. The magnitude of the pressure increase may be a function of the difference between the interim rate target and the breathing rate. The interim rate target may be reduced in response to slowing breathing rate. The waveform cycles, inhalation to exhalation, when airflow decreases to a cycle threshold. Different interim rate targets have different cycle threshold functions that allow easier cycling as the interim rate targets decrease. Similarly, the waveform triggers, exhalation to inhalation, when airflow increases to a trigger threshold. Different interim rate targets have different trigger threshold functions that allow easier triggering as the interim rate targets decrease.

Abstract: The configurations herein are directed to a sleep trolley system for automation of sleep disruption. Such a unique system often includes a platform support system; a natural habitat chamber configured for an animal subject, wherein the natural habitat chamber is removeably disposed thereon the platform support system; an agitator disposed therein the natural habitat chamber, wherein the agitator is configured with a first magnetic component to provide magnetic coupling; a trolley affixed to the platform support system; wherein the trolley is configured with a second magnetic component, wherein the second magnetic component exerts a magnetic attraction force with the first magnetic component coupled to the agitator as disposed therein the natural habitat chamber; and a control system configured to move the trolley along a dimension of the platform support system so as to guide the agitator along a corresponding length of the natural habitat chamber via the magnetic attraction force.

Abstract: Detection and treatment of disordered breathing is disclosed, with treatment being primarily delivered using electrical stimulation of the diaphragm, either directly or by stimulating appropriate nerves.

Abstract: One aspect of the present disclosure relates to a system to facilitate at home neural monitoring. The system can include a wearable device and an external device. The wearable device can include an electrode configured to be placed behind a patient's ear to record an electroencephalogram (EEG) signal; an amplifier to amplify the EEG signal; a battery; and a wireless transmission system to transmit the amplified EEG signal. The external device can be configured to receive the amplified EEG signal and to perform analysis of the amplified EEG signal. In some instances, the external device can also provide neural stimulation (e.g., acoustic, visual, or electrical) to the wearable device in response to analysis of the amplified EEG signal.

Abstract: A breathing apparatus and system include a breathing apparatus having a display, an internal memory unit, and a processing unit, and optionally an interface for connecting at least an external memory unit to the apparatus; optionally an external memory unit connectable to the breathing apparatus via the interface; wherein the processing unit is in operative communication with the display, the internal memory unit, and/or the external memory unit when connected to the apparatus via the interface, and the processing unit is configured to provide on at least a portion of the display, a user selectable background stored on at least one of the internal and/or external memory unit, such as a background image, or a background color different than a factory default background color that is not selectable by a user.