Abstract: A device for collecting blood, comprising: a tubular member having a diameter D1 enclosing an interior volume having a rated capacity, a distal end of the tubular member provided with a tip having a first through-hole in fluid communication with the interior volume, a proximal end of the tubular member provided a second through-hole in fluid communication with the interior volume; a cap formed of a self-healing material and configured to seal the tip of the tubular member; and a plunger movably accommodated within the interior volume of the tubular member, the plunger including an elongate member having an enlarged pad provided on a proximal end, an elastomeric member provided on a distal end and one or more locking wing members provided on and biased to extend away from the elongate member; wherein when the plunger is retracted to the rated capacity, the one or more locking wing members extend beyond the interior volume and engage with the proximal end of the tubular member.

Abstract: An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam.

Abstract: Apparatuses and methods of using them to collect blood, are provided, by first ensuring that the patient's skin is properly cleaned, to prevent contamination of the collected blood. One feature is a blood collection device configured to collect blood from a patient. Another feature is a scrub timer integrated into the device and configured to indicate to a user a scrub time period prior to beginning a blood draw process. The scrub timer can be configured to audibly and/or visually indicate to a user the start and stop times of a scrub cleaning process. In one embodiment, the scrub timer can be restarted, either manually or automatically, if the scrub cleaning process is not followed properly.

Abstract: Systems and methods for evaluating multiple candidate sensing vectors for use in sensing electrical activity of a heart are disclosed. The system can sense physiologic signals using each of a plurality of candidate sensing vectors, and generate respective signal intensity indicators and interference indicators using the physiologic signals sensed by using the respective sensing vectors. The system can also receive electrode information of each of the candidate sensing vectors, including information about sensing electrodes that are also used for delivering cardiac electrostimulation. The system can rank at least some of the plurality of candidate sensing vectors according to the signal intensity indicators, the interference indicators, and the electrode information. The system can also include a user interface for displaying the ranked sensing vectors, and allowing the user to select at least one sensing vector for use in sensing the cardiac electrical activity.

Abstract: Methods and systems for implantably determining a patient's anemia status and treating anemia are described. Blood viscosity is compared one or more thresholds to determine a patient's anemia status. Therapy, in the form of electrical stimulation therapy or administration of a pharmaceutical delivered to the patient's kidneys or hypothalamus is controlled based on the anemia status.

Abstract: The present invention is device for delivering an electrode into a lateral vein of the coronary sinus. The device includes a support structure, a stent, a tether coupled to the stent and a removable sheath disposed about the stent. The stent is carried on the support structure and is deployable from a first collapsed configuration to a second expanded configuration for engaging the inner walls of the selected vessel. The sheath is sized to retain the stent in the first collapsed configuration. The electrode is carried on the stent or on a lead threaded over the tether.

Abstract: An apparatus and method for determining the density and fluid-type of a fluid flowing in a capillary tube, the velocity and viscosity of a blood sample flowing in a capillary tube, the erythrocyte sedimentation rate (ESR) of a blood sample after flow has been brought to an abrupt stop in a capillary tube, and/or the zeta sedimentation rate (ZSR) of a blood sample after flow has been brought to an abrupt stop in a capillary tube. These measurements are accomplished by directing a waveform pulse, such as an ultrasound pulse, at a pre-determined frequency transversely across the capillary tube and sample fluid, and by determining the flight of time of the pulse through the capillary tube and sample fluid and/or the Doppler shift of the echo signals reflecting off cells moving forwardly or transversely within a flowing, or stationary, blood sample.

Abstract: Method and apparatus to determine the speed of sedimentation of blood and other parameters connected thereto, said method being carried out by detecting the development over time of the optical density, or absorbance, of a sample of blood, said sample being sent in the form of a flow inside a capillary container (12), said detection being made in correspondence with a point of said capillary container (12) and the relative data acquired being processed to obtain said speed of sedimentation and said connected parameters, said method providing to instantly interrupt the flow of the blood sample flowing inside said capillary container (12), in order to determine a thickening of the red cells in said blood sample and their consequent sedimentation, said detection being made substantially simultaneously with said instant interruption.

Abstract: A constriction device that constricts body tissue includes fixation structures for fixing the device on constricted body tissue. The device includes an elongated sleeve including an inner surface and opposed opened ends. The device is formed from expandable or elastic material so that when in an expanded condition, body tissue to be constricted may be received therein and thereafter, when released from the expanded condition, the body tissue is constricted by the device. The fixation structures include a plurality of fixation elements on the inner surface of the sleeve that grasp the body tissue upon release of the sleeve from the expanded condition to fix the device on the constricted tissue.

Abstract: A control and system for blood testing, including a control having stabilized blood cells that have been introduced into a suspension including an aggregating agent and preferably a surfactant. The control and system is used advantageously for indirect acute protein plasma measurement, including erythrocyte sedimentation rate testing.

Abstract: A blood viscosity measuring system and method that monitors the rising head of a column of fluid representing a living being's blood in-vivo to determine the blood viscosity over a range of shears. The system includes a capillary tube, at least a portion of which is located within the vascular system of the being, and a riser tube, having a liquid therein coupled to the capillary tube. A sensor and associated microprocessor are provided to determine the change in the height of the liquid in the riser tube at plural points along the length of the tube from which the viscosity is calculated.

Abstract: A method and apparatus for testing the efficacy of agents (e.g., new drugs, old drugs, biologically-active agents, etc.) by removing a predetermined amount of blood from a living being and placing this predetermined amount of blood in continuous motion in a temperature-controlled environment and then removing samples from the continuously-moving predetermined amount of blood. The drug, or drugs, or agents under test can then be administered to the removed samples, instead of into the living being, thereby avoiding subjecting the living being to any risk of any adverse reaction while utilizing blood samples that simulate the circulating blood of the living being.

Abstract: A three-phase suspension suitable for use as an erythrocyte sedimentation rate control having the following three components: (1) a synthetic plasma base, (2) a high molecular weight polymer, and (3) mammalian red blood cells. The control is designed to allow the user to monitor the accuracy and precision of analytical methods for determining the sedimentation rate of human erythrocytes in whole blood specimens.

Abstract: In a method for measuring in vivo coagulation rate, a fold of organic tissues is clamped so that a target blood vessel contained in the organic tissues is closed at a downstream point and an upstream point spaced from one another. Waveform energy is then directed through the clamped organic tissues. Waveform energy transmitted at least partially through the organic tissues is analyzed to determine a state of coagulation of blood trapped in the blood vessel between the downstream point and upstream point.

Abstract: This invention includes a method of determining the viscosity and the pressure gradient in a blood vessel, including the acquisition of n.gtoreq.2 blood speed values, corresponding to the same number of n radii of the blood vessel, determined along a diameter situated in a given axial position, formation of a blood speed vector by means of said n blood speed values, and evaluation of said viscosity and pressure gradient on the basis of a transformation of said blood speed value, including formation of a linear relation which directly links a flow rate vector (y) to the speed derivative vector (h), factorized by the viscosity (.mu.), and to the pressure gradient vector (.sigma.), and simultaneous evaluation of the two values to be determined for the viscosity (.mu.) and the pressure gradient (.sigma.) on the basis of said direct equation. The velocities are advantageously determined by correlation of ultrasonic signals supplied by an echography apparatus.

Abstract: A presealed integral hematocrit test assembly includes a holder, a bore molded into the holder, and a blood sample tube mounted on the holder adapted to receive a sample of blood by capillary action, whereby the blood sample tube is filled with blood from its inlet end by capillary action, and the test assembly is centrifuged into a column having a red corpuscles portion, white corpuscles portion, and a plasma portion. The method of using the presealed integral hematocrit test assembly includes the steps of measuring the length of the red cells column portion and measuring the total length of the blood column, and dividing the length of the red cells column portion by the total length of the blood column to make the hematocrit determination.

Abstract: A three-phase solution suitable for use as an erythrocyte sedimentation rate control having the following three components: (1) a synthetic plasma base, (2) a high molecular weight polymer, and (3) mammalian red blood cells. The control is designed to allow the user to monitor the accuracy and precision of analytical methods for determining the sedimentation rate of human erythrocytes in whole blood specimens.