Sensitivity Of Skin To Allergens Or Radiation Patents (Class 600/556)
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Patent number: 11957477Abstract: An allergen delivery system with a tray and delivery set. The delivery set includes a dispensing well. The dispensing well holds a wettable material to receive an allergen and provide it to a delivery barb that has been received into the dispensing well. A conduit is connected to the dispensing well, to receive the allergen and provide it to the dispensing well. A reservoir is connected to the conduit to receive the allergen and provide it to the conduit. A cap is disposed on the reservoir, with a hole, such that when a finger depresses the cap, the finger covers the hole and the depression creates pressure within the reservoir, which motivates an amount of the allergen to flow out from the reservoir through the conduit and into the dispensing well, to be absorbed by the wettable material, where the allergen is available for delivery to the barbed delivery applicator.Type: GrantFiled: May 9, 2023Date of Patent: April 16, 2024Inventors: Ty L. Prince, Herman J. Novak
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Patent number: 11911172Abstract: An automated allergy office system and method provides a medical professional with a new allergy treatment plan to administer to a patient. The automated allergy office system comprises a viewing device to select a test site on the patient's skin that is clear. A multiple test applicator is in cooperative engagement with a fluid tray and delivers a small amount of a first allergen to a first test site on the patient's skin as a small amount of a second allergen is delivered to a second test site on the patient's skin. The allergy condition of the patient is detected as a wheal forms at the first test site after fifteen minutes. The elements of the treatment plan are retrieved from a database for treating the patient's allergy condition. The patient's electronic medical record is checked to confirm that the allergy treatment is new for this patient.Type: GrantFiled: December 9, 2022Date of Patent: February 27, 2024Inventors: Ty L. Prince, Herman J. Novak
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Patent number: 11783207Abstract: A system includes a memory having instructions therein and at least one processor in communication with the memory. The at least one processor is configured to execute the instructions to acquire phytomorphological field data via a sensor component of a mobile robot, generate, based on the phytomorphological field data and via a machine learning agent, a predicted likelihood of whether a hypothetical action by the mobile robot against a found plant would be directed against a true Toxicodendron plant, conduct a non-phytomorphological assessment of the found plant via the mobile robot and based on the predicted likelihood being below a first threshold and above a second threshold, and, via the mobile robot and based on the non-phytomorphological assessment, attack the found plant, mark a site of the found plant, and/or document a context of the site.Type: GrantFiled: February 18, 2020Date of Patent: October 10, 2023Assignee: International Business Machines CorporationInventors: Barton Wayne Emanuel, Nadiya Kochura, Tiberiu Suto, Vinod A. Valecha
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Patent number: 11744937Abstract: Provided is a flexible and conformal wearable, self-contained medical device. The medical device comprises an integral housing formed by a flexible upper portion and a flexible lower portion joined along their perimeters. The medical device is also provided in a plurality of shapes and configurations for increasing the flexibility and conformability of the housing. The components contained within the housing, such as a drug reservoir, printed circuit board, and power supply are preferably constructed from flexible materials and are formed, connected and positioned according to the configuration of the housing in a manner for enhancing flexibility of the housing. A thermal bubble micropump is provided for controlling flow of a drug from the flexible reservoir, that utilizes a thermal resistor provided locally to a thermal expansion fluid that causes a surrounding membrane to expand and displace a volume of drug to be provided to the user.Type: GrantFiled: June 11, 2021Date of Patent: September 5, 2023Assignee: Becton, Dickinson and CompanyInventors: Gary Searle, Keith N. Knapp, Peter Skutnik, Aidan Petrie, Dan Nelsen, Paul Brown
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Patent number: 11696722Abstract: A multiple test applicator has a first and second scratching barb in cooperative engagement with each other and a first and second reservoir in a fluid tray each filled with a first and second allergen. During allergen loading, the first allergen is loaded onto the first scratching barb as the second allergen is loaded onto the second scratching barb. Then, during allergen deposition the applicator is removed from the fluid tray and the first scratching barb moves laterally across the patient's skin as the second scratching barb moves laterally across the patient's skin toward the first scratching barb. The first scratching barb then scratches the epidermis at a first test site as a trace amount of the first allergen is deposited into a first site as the second scratching barb scratches a second site as a trace amount of the second allergen seeps into the second site.Type: GrantFiled: November 22, 2022Date of Patent: July 11, 2023Inventor: Ty L. Prince
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Patent number: 11517249Abstract: The multiple allergen testing system includes an applicator and a fluid tray. The fluid tray is cooperatively engageable with the applicator. The applicator has an allergen loading position and an allergen deposition position. In the allergen loading position, a different allergen is loaded onto each respective scratching barb from each respective reservoir of the loading tray. Each scratching barb is designed to retain a trace of allergen fluid. A pair of finger grips are positioned on opposing sides of the applicator frame. The applicator fits into one hand of a medical technician administering the allergen skin testing. The applicator is removed from the fluid tray and repositioned onto the skin of the patient. The applicator is made of compressible material. In the allergen deposition position, the applicator is compressed, and each allergen is deposited into each respective scratch generated by each respective scratching barb on the skin for further analysis.Type: GrantFiled: August 13, 2021Date of Patent: December 6, 2022Inventor: Ty L. Prince
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Patent number: 11471607Abstract: Medication delivery devices, sensing systems, and methods are disclosed for determining the relative axial and rotational movements of its members to determine the amount of a dose set and/or delivered by the medication delivery device. A sensing system comprises a barrel sensor system (100), a drive sleeve sensor system (130), and/or an axial sensor system (140). The barrel sensor system (100) is for detecting the absolute relative angular position of the barrel relative to the housing during dose setting. The drive sleeve sensor system (130) is for detecting the absolute relative angular position of the drive sleeve relative to the housing during dose delivery. The axial sensor system (140) is for detecting the relative axial positions of the dose dial relative to the housing during dose setting and delivery. A controller receives outputs from the sensor systems corresponding to the absolute relative positions to determine the actual amounts of dose set and delivered.Type: GrantFiled: August 4, 2017Date of Patent: October 18, 2022Assignee: Eli Lilly and CompanyInventors: Nicola Antonio Alagia, Roy Howard Byerly, Rossano Claudio Massari, Russell Wayne Perkins
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Patent number: 11464462Abstract: The invention relates to a drug abuse prevention device and a method thereof, said device comprising a sweat analysis system configured to determine content of drugs from sweat of a user; an air quality determination unit configured to determine the presence of drug contents in the air, a processor configured to compare the determined content of drugs in air and sweat of user with pre determined drug levels; and an auto trigger unit configured to trigger one or more registered users regarding the presence of drugs upon violation of predetermined drug levels.Type: GrantFiled: June 3, 2021Date of Patent: October 11, 2022Inventor: Mirza Faizan
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Patent number: 11426110Abstract: An envelope is comprised of two sheets of material that are placed one on top of each other with their interior sides facing each other with their edges sealed to each other with an adhesive to form an airtight enclosure. The envelope has at least one medical patch inside it that is attached to the interior side of at least one of the sheets and a layer of medical grade pressure sensitive adhesive surrounding the at least one medical patch. The pressure sensitive adhesive is applied to a part of the surface of the interior side of the sheet in order to attach the sheet of material and the at least one medical patch to the body of a patient. The medical patch can be an electrode for measuring a patient's vital signs or delivering an electric shock or a transdermal patch for delivering a drug to a patient.Type: GrantFiled: February 14, 2017Date of Patent: August 30, 2022Assignee: INOVYTEC MEDICAL SOLUTIONS LTD.Inventors: Ehud Kantor, Nir Barkai
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Patent number: 11369782Abstract: The method for administering a plurality of allergens into the skin of a patient uses a multiple test applicator in cooperative engagement with a fluid tray. The applicator has a plurality of scratching barbs each aligned with a plurality of reservoirs in the fluid tray. The method deploys allergen loading followed by allergen deposition. During allergen loading, a different allergen is loaded onto each respective scratching barb from each respective reservoir. Each scratching barb is designed to retain a trace amount of allergen. The applicator fits into one hand of a medical technician administering the skin test. The applicator is removed from the fluid tray and repositioned onto the skin of the patient for allergen deposition. Then, each scratching barb pierces the outer layer of the skin at each respective test site as a trace amount of each respective allergen seeps into each respective test site from each scratching barb.Type: GrantFiled: September 7, 2021Date of Patent: June 28, 2022Inventor: Ty L. Prince
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Patent number: 11317670Abstract: Interactive therapeutic devices for wear on a head of a user are provided herein, along with kits including the interactive therapeutic device and an activity book, and methods of using the devices and kits. Contemplated devices comprise a set of attachment points that removably couple with a set of patches via fastener components. The patches can include various types of patches that provide different benefits to the wearer, including style, a scent, a noise, a tactile sensation, protection, and/or the ability to better communicate a feeling and/or a need.Type: GrantFiled: June 18, 2020Date of Patent: May 3, 2022Assignee: Inspire Create, LLCInventor: Shannon Marie Davis
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Patent number: 11154237Abstract: A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.Type: GrantFiled: October 15, 2019Date of Patent: October 26, 2021Assignee: ROCA MEDICAL LTD.Inventors: James Strader, Jovan Hutton Pulitzer
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Patent number: 11123531Abstract: An integrated-type microneedle patch according to the present invention includes: a needle unit (10) including an array of microneedles (12) for skin puncturing, and a needle base (11) supporting the array of the microneedles (12); an active ingredient portion (30) containing an active ingredient that consists of a drug or a functional cosmetic ingredient; and a patch unit (20) including a protective patch layer (21) covering the active ingredient portion (30) and protecting skin after a procedure, wherein the active ingredient portion (30) is located toward the skin with respect to the protective patch layer (21), and the needle base (11) is located opposite to the skin with respect to the protective patch layer (21), whereby the needle unit (10) is separated from the patch unit (20) after a skin puncture procedure using the microneedles (12) is performed.Type: GrantFiled: May 10, 2019Date of Patent: September 21, 2021Inventor: Sanghyuk Lee
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Patent number: 11020043Abstract: A device (10) for performing an allergy test comprising a container unit (11) having a first surface (12) and a second surface (13). The container unit (11) comprising a plurality of cavities (22) each arranged for receiving an allergen container (14) comprising a supporting material (18) and a pricking tool, which is secured at a location of the supporting material (18). The supporting material (18) is arranged, when a pressure force is applied on the second surface (13), for being compressed thereby causing the pricking tool (19) for being displaced from a first position (25), wherein at said first position the at least one pricking tip (24) is at a first distance from the first surface (12), to a second position (26), wherein at said second position (26) the at least one pricking tip (24) is at a second distance from the first surface (12).Type: GrantFiled: August 21, 2015Date of Patent: June 1, 2021Assignee: PROF. DR. CLAUS BACHERT BVBAInventor: Claus Bachert
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Patent number: 11006891Abstract: Methods and items useful at least therein are provided for IBS related testing and treatment. Disclosed is a patch useful in determining if one or more test materials can cause allergic contact dermatitis in a patient. A kit containing information on use and that may include such a patch and/or test material(s) is also disclosed. A method of IBS related testing including performing skin patch testing on a patient presenting IBS symptoms using at least one test material that can cause allergic contact dermatitis is provided. A method for the treatment of IBS which includes limiting the intake by a patient presenting IBS symptoms of at least one material that gives a positive skin patch test result in the patient is also disclosed.Type: GrantFiled: March 2, 2017Date of Patent: May 18, 2021Assignee: IBS CENTERS FOR ADVANCED FOOD ALLERGY TESTING, LLCInventor: Michael Stierstorfer
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Patent number: 10945655Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.Type: GrantFiled: September 14, 2017Date of Patent: March 16, 2021Assignee: ST-9 Inc.Inventor: Marvin Smollar
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Patent number: 10899517Abstract: A sanitary wipe is provided, including a pad that is contained beneath or as part of an adhesive sticker or otherwise attachable body that is releasably secured at any convenient point on a surface of a container or containment vessel, such as the side or top of the containment vessel. The pad can be provided with or without a cleaning substance. For use, the user simply pulls the adhesive sticker or attachable body free of the container, and uses the wipe part or pad of the sticker or body to clean and remove contamination wherever contamination is suspected or at any other desired location, like on the lid of the containment vessel.Type: GrantFiled: April 3, 2015Date of Patent: January 26, 2021Inventors: Taso Georgas, George Michalopoulos
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Patent number: 10722158Abstract: A handheld oximeter probe has a replaceable probe tip. The probe tip can be removed or detached from the probe unit and discarded. A replacement probe tip can be attached to the probe tip. The replaceable probe tip allows the probe unit to be reused many times, each time with new sterile probe tip.Type: GrantFiled: April 20, 2017Date of Patent: July 28, 2020Assignee: ViOptix, Inc.Inventors: Joseph Heanue, Scott Coleridge, Sophia Elizabeth Berger
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Patent number: 10702203Abstract: A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.Type: GrantFiled: February 8, 2017Date of Patent: July 7, 2020Assignee: ROCA Medical Ltd.Inventors: James Strader, Jovan Hutton Pulitzer
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Patent number: 10470698Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.Type: GrantFiled: November 28, 2016Date of Patent: November 12, 2019Assignee: Lincoln Diagnostics, Inc.Inventors: Gary L. Hein, Jr., Douglas S. Hein
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Patent number: 10390753Abstract: A blister strip which can be stuck onto the skin, is formed from at least two sheets and has an applicator for applying a medium contained in the blister to the skin, wherein the blister strip includes an upper sheet, with at least one protuberance, wherein the underside of the upper sheet, the underside enclosing the protuberance, is of adhesive configuration. The blister strip has a lower sheet, which covers the lower surface of the blister strip and can be drawn off from the adhesive underside of the upper sheet. The protuberance contains an applicator, separating the protuberance into at least two sub-volumes. Wherein the applicator has at least one opening, which connects two sub-volumes, wherein one sub-volume is located between the applicator and the lower sheet, and wherein at least one sub-volume is entirely surrounded by the inner surface of the protuberance and the applicator, and contains the medium.Type: GrantFiled: October 16, 2015Date of Patent: August 27, 2019Assignee: ALLTEST GmbHInventor: Bernhard Forstner
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Patent number: 9788780Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.Type: GrantFiled: July 11, 2014Date of Patent: October 17, 2017Inventor: Marvin Smollar
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Patent number: 9655556Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.Type: GrantFiled: April 14, 2016Date of Patent: May 23, 2017Inventor: Marvin Smollar
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Patent number: 9649483Abstract: A drug delivery device that delivers pharmacologically active substances transdermally using microneedles arranged on a belt mounted rotatably about a plurality of rollers, the microneedles having an associated drug reservoir mounted on the belt which is compressed when the needles and belt are brought into contact with the skin.Type: GrantFiled: October 15, 2009Date of Patent: May 16, 2017Inventor: Dewan Fazlul Hoque Chowdhury
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Patent number: 9597030Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.Type: GrantFiled: April 14, 2016Date of Patent: March 21, 2017Inventor: Marvin Smollar
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Patent number: 9504418Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.Type: GrantFiled: April 17, 2015Date of Patent: November 29, 2016Assignee: Lincoln Diagnostics, Inc.Inventors: Gary L. Hein, Jr., Douglas S. Hein
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Patent number: 9308330Abstract: A delivery device (10) includes a roller (12) rotatably mounted on an axle (14), a reservoir (40), and one or more hollow needles (16) positioned in the roller (12) in fluid communication with the reservoir (40). As the roller (12) rotates about the longitudinal axis (17) of the axle (14), a piston (30) pushes contents of the reservoir (40) through the needles (16). An actuator (36) is operatively connected to the piston (30) for increasing a pushing force of the piston (30).Type: GrantFiled: July 10, 2013Date of Patent: April 12, 2016Assignee: Roller Jet Ltd.Inventors: Amir Waldman, Tal Presenty
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Patent number: 9060730Abstract: A method and a kit for quantification of at least one predictor promoting at least one multifactorial disease, intended for use in assessment of the risk for developing or progression of the at least one multifactorial disease for a subject are disclosed. The kit comprises a plurality of reservoir units (320), each reservoir unit (320) being arranged to releasably retain a skin irritation agent adapted to provoke an unspecific inflammatory response of skin. The kit comprises an estimation unit adapted to estimate a quantification of the at least one predictor on basis of an assessment of the at least one predictor performed by a user on basis of an assessment of the degree of severity of the inflammatory response to the skin irritation agent at each of a plurality of skin sites according to a predetermined inflammatory response criteria performed by the user and relative impact of the at least one predictor on the progress of the at least one multifactorial disease.Type: GrantFiled: December 30, 2009Date of Patent: June 23, 2015Assignee: DENTOSYSTEM SCANDINAVIA ABInventor: Sven Lindskog
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Publication number: 20150126898Abstract: The present invention discloses a system for applying antigens or other diagnostic substances to the skin of a subject for allergy testing. The system is comprised of fully contained predetermined quantities of antigenic or other testing material contained in sealed unit doses that maintain sterility and provide for precise handling and administration. Each unit dose contains an internal mechanism. The mechanism provides for piercing the laminate and comprises an internal channel for fluid communication, and may have an abrasive protrusions at the tip for piercing or abrading the skin surface to aid in generating a diagnostic response. The unit dose or doses may be housed in devices that provide for administration of the test material to the subject wherein the applicator section may contain protrusions for piercing or abrading the skin of a subject.Type: ApplicationFiled: August 28, 2013Publication date: May 7, 2015Applicant: Mystic Pharmaceuticals, Inc.Inventors: Timothy R. Sullivan, Jeff Gjersten, Jesse Hancock
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Patent number: 9011350Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.Type: GrantFiled: June 24, 2013Date of Patent: April 21, 2015Assignee: Lincoln Diagnostics, Inc.Inventors: Gary L. Hein, Jr., Douglas S. Hein
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Publication number: 20150025412Abstract: An allergy skin test kit includes a template having puncture site indicators and a computer-readable storage medium storing allergy test information that associates the puncture site indicators of the template with template locations or test substance indicators. A method of performing an allergy skin test includes providing a template having puncture site indicators. Allergy test information that associates the puncture site indicators of the template with template locations or test substances identifiers is obtained. Image data corresponding to a test area on the skin of a test subject obtained and image regions corresponding to the puncture site indicators of the template are identified. Test results corresponding to the image regions are determined based, at least in part, on the allergy test information.Type: ApplicationFiled: July 22, 2014Publication date: January 22, 2015Inventors: Sherwin A. Gillman, Alfredo Jalowayski
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Publication number: 20140276196Abstract: An allergy testing device is formed by a blister pack containing a series of collapsible chambers each associated with an allergen and a lancet. The allergy testing device may be placed adjacent to a patient's skin and actuated by applying pressure to the collapsible chambers to open the chambers and release the reagents contained therein. The lancets deliver the allergen to the skin. The allergy testing device may apply marking to the skin to allow accurate measurement of the allergy testing results.Type: ApplicationFiled: March 13, 2014Publication date: September 18, 2014Applicant: ALLERGY DEVICES, INC.Inventors: Mark Q. Niederauer, Patrick Strauss
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Publication number: 20140276197Abstract: A system, a method, and an apparatus are described herein for determining skin test sensitivities. A first skin test to evaluate a patient's skin reaction to one or more allergens may he performed. After measurements are taken of any reactions to the first skin test, a second skin test may be performed based on the results of the first skin test. Based on the results of the second test, an appropriate treatment endpoint for the patient may be determined. A computer-implemented method may be used for determining skin test sensitivities that may guide a user through one or more appropriate test selection and treatment endpoint determinations.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: GREER LABORATORIES, INC.Inventors: TOM GRIER, DONNA REKKERTH, MARTY JOHNSON, TIFFANY AHLERS, CURTIS ANDREWS
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Patent number: 8764675Abstract: An electrode for applying electric fields to a patient includes a plurality of ceramic elements (e.g., ceramic discs) that are designed to be positioned against the patient's skin. Electrical connections are made to the ceramic elements (e.g., using a flex circuit). Temperature sensors (e.g., thermistors) are preferably provided at at least some of the ceramic elements to sense the temperature at the skin beneath the ceramic elements, so that appropriate action can be taken if an overtemperature condition is detected.Type: GrantFiled: March 8, 2013Date of Patent: July 1, 2014Assignee: Novocure LtdInventor: Yoram Palti
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Patent number: 8715203Abstract: An electrode for applying electric fields to a patient includes a plurality of ceramic elements (e.g., ceramic discs) that are designed to be positioned against the patient's skin. Electrical connections are made to the ceramic elements (e.g., using a flex circuit). Temperature sensors (e.g., thermistors) are preferably provided at at least some of the ceramic elements to sense the temperature at the skin beneath the ceramic elements, so that appropriate action can be taken if an overtemperature condition is detected.Type: GrantFiled: September 17, 2007Date of Patent: May 6, 2014Assignee: Novocure LimitedInventor: Yoram Palti
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Patent number: 8597199Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.Type: GrantFiled: October 11, 2010Date of Patent: December 3, 2013Inventors: Ziv Harish, Isaac Rubinstein, Ehud Arbit, Russ Weinzimmer
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Publication number: 20130289440Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.Type: ApplicationFiled: June 24, 2013Publication date: October 31, 2013Inventors: Gary L. Hein, JR., Douglas S. Hein
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Publication number: 20130245492Abstract: A driver for engaging and dispensing fluid from a sealed, prefilled syringe is provided. The driver includes a body and a rotating actuator configured to engage a plunger of the prefilled syringe. The driver is configured such that rotation of the rotating actuator relative to the body imparts both rotational movement and axial movement to a plunger of the prefilled syringe resulting in ejection of fluid from the prefilled syringe.Type: ApplicationFiled: March 15, 2012Publication date: September 19, 2013Applicant: SMARTHEALTH, INC.Inventors: Karl-Michael Klenk, Curtis P. Hamann, Bryan Richard Falk
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Publication number: 20130231583Abstract: The present invention discloses methods, devices and systems for intradermal delivery comprising injection delivery guide devices as described herein. An injection delivery guide device may comprise a carrier member and at least one indentation applicator. Such methods, devices and systems are useful in intradermal administration of solutions comprising active agents.Type: ApplicationFiled: February 28, 2013Publication date: September 5, 2013Inventor: Donna Rekkerth
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Patent number: 8469900Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.Type: GrantFiled: November 30, 2011Date of Patent: June 25, 2013Assignee: Lincoln Diagnostics, Inc.Inventors: Gary L. Hein, Jr., Douglas S. Hein
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Publication number: 20130138013Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.Type: ApplicationFiled: November 30, 2011Publication date: May 30, 2013Applicant: LINCOLN DIAGNOSTICS, INC.Inventors: Gary L. Hein, JR., Douglas S. Hein
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Publication number: 20130052139Abstract: A method and a kit for quantification of at least one predictor promoting at least one multifactorial disease, intended for use in assessment of the risk for developing or progression of the at least one multifactorial disease for a subject are disclosed. The kit comprises a plurality of reservoir units (320), each reservoir unit (320) being arranged to releasably retain a skin irritation agent adapted to provoke an unspecific inflammatory response of skin The kit comprises an estimation unit adapted to estimate a quantification of the at least one predictor on basis of an assessment of the at least one predictor performed by a user on basis of an assessment of the degree of severity of the inflammatory response to the skin irritation agent at each of a plurality of skin sites according to a predetermined inflammatory response criteria performed by the user and relative impact of the at least one predictor on the progress of the at least one multifactorial disease.Type: ApplicationFiled: December 30, 2009Publication date: February 28, 2013Inventor: Sven Lindskog
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Patent number: 8386027Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.Type: GrantFiled: April 25, 2008Date of Patent: February 26, 2013Assignee: Echo Therapeutics, Inc.Inventors: Han Chuang, Juan P. Eslava, James P. Hurley, Debashis Ghosh, Keith Krystyniak, Scott C. Kellogg
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Patent number: 8363259Abstract: A method is described for producing printed patches to provide a plurality of color markings and high-contrast markings as aligned arrangements of fiducial points. The printed color markings facilitate optical image processing and the printed high-contrast markings facilitate high-contrast image processing. These fiducial points enable a visible area of interest to be located by a person and associated with relevant high-contrast imaging data. This method includes providing a patch; printing at least one arrangement of color markings on the patch; and printing at least one arrangement of high-contrast markings on the patch. According to further features of certain embodiments the markings are aligned, can designate the same point, or can be disjointed.Type: GrantFiled: January 29, 2009Date of Patent: January 29, 2013Assignee: Activiews Ltd.Inventor: Pinhas Gilboa
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Patent number: 8317721Abstract: The present invention provides a device and method for skin testing. The device includes a handle assembly connected to a cylinder assembly having a first and second cylinder housing. Each cylinder housing is connected to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin and a socket assembly that is structured and operable to pivot the testing head to apply equal and even pressure to all the pins. Further, the method provides positioning the device tangent to the surface of the skin, and pivoting the testing head assembly horizontally to apply equal and even pressure to the pins.Type: GrantFiled: October 14, 2010Date of Patent: November 27, 2012Inventors: Patrick Win, Edwin A. Reed
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Patent number: 8282571Abstract: The present invention provides a device for skin testing. The device includes a handle assembly connected to a cylinder assembly having two mutually parallel and spaced apart cylinder housings. Each cylinder housing connects to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin. Each head assembly has a collar and cooperating tip structured to pivot the testing head on two axes only and still apply even pressure to the pins. Each testing head readily inserts into the collar for usage and ejects promptly from the handle using a trigger mechanism. The cylinder housing construction minimizes accumulation of detritus therein.Type: GrantFiled: December 30, 2011Date of Patent: October 9, 2012Inventors: Patrick H. Win, Edwin A. Reed, IV
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Publication number: 20120253224Abstract: An apparatus and method for making an apparatus for skin testing includes a housing with an opening which defines a field of view of a skin testing region, an image sensing apparatus, an illumination apparatus, a binding apparatus, and an image processing controller. The image sensing apparatus is positioned with respect to the housing to capture images in the field of view provided by the opening. The illumination apparatus is positioned within the housing to direct light towards a portion of the field of view provided by the opening. The binding apparatus detachably secures the housing over the skin testing region and maintains a fixed distance between the image sensing apparatus and the skin testing region. The controller is configured to analyze test samples sites in each of the captured images from the image sensing apparatus and provide a skin test result for each of the test sample sites.Type: ApplicationFiled: October 13, 2011Publication date: October 4, 2012Applicant: SENSIVIDA MEDICAL TECHNOLOGIES, INC.Inventors: Jose Mir, John Spoonhower, John A. Agostinelli, John Squilla
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Publication number: 20120101406Abstract: The present invention provides a device for skin testing. The device includes a handle assembly connected to a cylinder assembly having two mutually parallel and spaced apart cylinder housings. Each cylinder housing connects to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin. Each head assembly has a collar and cooperating tip structured to pivot the testing head on two axes only and still apply even pressure to the pins. Each testing head readily inserts into the collar for usage and ejects promptly from the handle using a trigger mechanism. The cylinder housing construction minimizes accumulation of detritus therein.Type: ApplicationFiled: December 30, 2011Publication date: April 26, 2012Inventors: PATRICK H. WIN, Edwin A. Reed, IV
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Publication number: 20120089048Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.Type: ApplicationFiled: October 11, 2010Publication date: April 12, 2012Inventors: Ziv Harish, Isaac Rubinstein, Ehud Arbit, Russ Weinzimmer
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Patent number: RE46823Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.Type: GrantFiled: December 3, 2015Date of Patent: May 8, 2018Inventors: Ziv Harish, Isaac Rubinstein, Ehud Arbit, Russ Weinzimmer