Sensitivity Of Skin To Allergens Or Radiation Patents (Class 600/556)
  • Patent number: 11369782
    Abstract: The method for administering a plurality of allergens into the skin of a patient uses a multiple test applicator in cooperative engagement with a fluid tray. The applicator has a plurality of scratching barbs each aligned with a plurality of reservoirs in the fluid tray. The method deploys allergen loading followed by allergen deposition. During allergen loading, a different allergen is loaded onto each respective scratching barb from each respective reservoir. Each scratching barb is designed to retain a trace amount of allergen. The applicator fits into one hand of a medical technician administering the skin test. The applicator is removed from the fluid tray and repositioned onto the skin of the patient for allergen deposition. Then, each scratching barb pierces the outer layer of the skin at each respective test site as a trace amount of each respective allergen seeps into each respective test site from each scratching barb.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: June 28, 2022
    Inventor: Ty L. Prince
  • Patent number: 11317670
    Abstract: Interactive therapeutic devices for wear on a head of a user are provided herein, along with kits including the interactive therapeutic device and an activity book, and methods of using the devices and kits. Contemplated devices comprise a set of attachment points that removably couple with a set of patches via fastener components. The patches can include various types of patches that provide different benefits to the wearer, including style, a scent, a noise, a tactile sensation, protection, and/or the ability to better communicate a feeling and/or a need.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: May 3, 2022
    Assignee: Inspire Create, LLC
    Inventor: Shannon Marie Davis
  • Patent number: 11154237
    Abstract: A method for administering tests using a regional antigen testing kit is provided. The method comprises providing the regional antigen testing kit, extracting a predetermined amount of concentrated antigen from one of a plurality of concentrated antigens, dispensing the predetermined amount of concentrated antigen into a corresponding one of a plurality of wells, as indicated by visual indicia, repeating the extracting and dispensing steps until a desired number of the plurality of wells contain concentrated antigen, providing a prick tester having a plurality of needles extending thereon, aligning the plurality of needles of the prick tester with the plurality of wells, inserting each of the plurality of needles of the prick tester into one of the plurality of wells, and applying the plurality of needles of the prick tester to the skin of a patient to elicit a potential response.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: October 26, 2021
    Assignee: ROCA MEDICAL LTD.
    Inventors: James Strader, Jovan Hutton Pulitzer
  • Patent number: 11123531
    Abstract: An integrated-type microneedle patch according to the present invention includes: a needle unit (10) including an array of microneedles (12) for skin puncturing, and a needle base (11) supporting the array of the microneedles (12); an active ingredient portion (30) containing an active ingredient that consists of a drug or a functional cosmetic ingredient; and a patch unit (20) including a protective patch layer (21) covering the active ingredient portion (30) and protecting skin after a procedure, wherein the active ingredient portion (30) is located toward the skin with respect to the protective patch layer (21), and the needle base (11) is located opposite to the skin with respect to the protective patch layer (21), whereby the needle unit (10) is separated from the patch unit (20) after a skin puncture procedure using the microneedles (12) is performed.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: September 21, 2021
    Inventor: Sanghyuk Lee
  • Patent number: 11020043
    Abstract: A device (10) for performing an allergy test comprising a container unit (11) having a first surface (12) and a second surface (13). The container unit (11) comprising a plurality of cavities (22) each arranged for receiving an allergen container (14) comprising a supporting material (18) and a pricking tool, which is secured at a location of the supporting material (18). The supporting material (18) is arranged, when a pressure force is applied on the second surface (13), for being compressed thereby causing the pricking tool (19) for being displaced from a first position (25), wherein at said first position the at least one pricking tip (24) is at a first distance from the first surface (12), to a second position (26), wherein at said second position (26) the at least one pricking tip (24) is at a second distance from the first surface (12).
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: June 1, 2021
    Assignee: PROF. DR. CLAUS BACHERT BVBA
    Inventor: Claus Bachert
  • Patent number: 11006891
    Abstract: Methods and items useful at least therein are provided for IBS related testing and treatment. Disclosed is a patch useful in determining if one or more test materials can cause allergic contact dermatitis in a patient. A kit containing information on use and that may include such a patch and/or test material(s) is also disclosed. A method of IBS related testing including performing skin patch testing on a patient presenting IBS symptoms using at least one test material that can cause allergic contact dermatitis is provided. A method for the treatment of IBS which includes limiting the intake by a patient presenting IBS symptoms of at least one material that gives a positive skin patch test result in the patient is also disclosed.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: May 18, 2021
    Assignee: IBS CENTERS FOR ADVANCED FOOD ALLERGY TESTING, LLC
    Inventor: Michael Stierstorfer
  • Patent number: 10945655
    Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: March 16, 2021
    Assignee: ST-9 Inc.
    Inventor: Marvin Smollar
  • Patent number: 10899517
    Abstract: A sanitary wipe is provided, including a pad that is contained beneath or as part of an adhesive sticker or otherwise attachable body that is releasably secured at any convenient point on a surface of a container or containment vessel, such as the side or top of the containment vessel. The pad can be provided with or without a cleaning substance. For use, the user simply pulls the adhesive sticker or attachable body free of the container, and uses the wipe part or pad of the sticker or body to clean and remove contamination wherever contamination is suspected or at any other desired location, like on the lid of the containment vessel.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: January 26, 2021
    Inventors: Taso Georgas, George Michalopoulos
  • Patent number: 10722158
    Abstract: A handheld oximeter probe has a replaceable probe tip. The probe tip can be removed or detached from the probe unit and discarded. A replacement probe tip can be attached to the probe tip. The replaceable probe tip allows the probe unit to be reused many times, each time with new sterile probe tip.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: July 28, 2020
    Assignee: ViOptix, Inc.
    Inventors: Joseph Heanue, Scott Coleridge, Sophia Elizabeth Berger
  • Patent number: 10702203
    Abstract: A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: July 7, 2020
    Assignee: ROCA Medical Ltd.
    Inventors: James Strader, Jovan Hutton Pulitzer
  • Patent number: 10470698
    Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: November 12, 2019
    Assignee: Lincoln Diagnostics, Inc.
    Inventors: Gary L. Hein, Jr., Douglas S. Hein
  • Patent number: 10390753
    Abstract: A blister strip which can be stuck onto the skin, is formed from at least two sheets and has an applicator for applying a medium contained in the blister to the skin, wherein the blister strip includes an upper sheet, with at least one protuberance, wherein the underside of the upper sheet, the underside enclosing the protuberance, is of adhesive configuration. The blister strip has a lower sheet, which covers the lower surface of the blister strip and can be drawn off from the adhesive underside of the upper sheet. The protuberance contains an applicator, separating the protuberance into at least two sub-volumes. Wherein the applicator has at least one opening, which connects two sub-volumes, wherein one sub-volume is located between the applicator and the lower sheet, and wherein at least one sub-volume is entirely surrounded by the inner surface of the protuberance and the applicator, and contains the medium.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: August 27, 2019
    Assignee: ALLTEST GmbH
    Inventor: Bernhard Forstner
  • Patent number: 9788780
    Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 17, 2017
    Inventor: Marvin Smollar
  • Patent number: 9655556
    Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: May 23, 2017
    Inventor: Marvin Smollar
  • Patent number: 9649483
    Abstract: A drug delivery device that delivers pharmacologically active substances transdermally using microneedles arranged on a belt mounted rotatably about a plurality of rollers, the microneedles having an associated drug reservoir mounted on the belt which is compressed when the needles and belt are brought into contact with the skin.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: May 16, 2017
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 9597030
    Abstract: An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms. The allergy testing tray contains a main body having an underside and a top surface, a cover for locking with the main body and a plurality of reservoirs extending from the underside of the main body. The reservoirs each have a chamber with an opening extending from the top surface. The reservoirs are disposed in different groups and each group has an asymmetrical configuration matching that of the applicator.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 21, 2017
    Inventor: Marvin Smollar
  • Patent number: 9504418
    Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: November 29, 2016
    Assignee: Lincoln Diagnostics, Inc.
    Inventors: Gary L. Hein, Jr., Douglas S. Hein
  • Patent number: 9308330
    Abstract: A delivery device (10) includes a roller (12) rotatably mounted on an axle (14), a reservoir (40), and one or more hollow needles (16) positioned in the roller (12) in fluid communication with the reservoir (40). As the roller (12) rotates about the longitudinal axis (17) of the axle (14), a piston (30) pushes contents of the reservoir (40) through the needles (16). An actuator (36) is operatively connected to the piston (30) for increasing a pushing force of the piston (30).
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: April 12, 2016
    Assignee: Roller Jet Ltd.
    Inventors: Amir Waldman, Tal Presenty
  • Patent number: 9060730
    Abstract: A method and a kit for quantification of at least one predictor promoting at least one multifactorial disease, intended for use in assessment of the risk for developing or progression of the at least one multifactorial disease for a subject are disclosed. The kit comprises a plurality of reservoir units (320), each reservoir unit (320) being arranged to releasably retain a skin irritation agent adapted to provoke an unspecific inflammatory response of skin. The kit comprises an estimation unit adapted to estimate a quantification of the at least one predictor on basis of an assessment of the at least one predictor performed by a user on basis of an assessment of the degree of severity of the inflammatory response to the skin irritation agent at each of a plurality of skin sites according to a predetermined inflammatory response criteria performed by the user and relative impact of the at least one predictor on the progress of the at least one multifactorial disease.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: June 23, 2015
    Assignee: DENTOSYSTEM SCANDINAVIA AB
    Inventor: Sven Lindskog
  • Publication number: 20150126898
    Abstract: The present invention discloses a system for applying antigens or other diagnostic substances to the skin of a subject for allergy testing. The system is comprised of fully contained predetermined quantities of antigenic or other testing material contained in sealed unit doses that maintain sterility and provide for precise handling and administration. Each unit dose contains an internal mechanism. The mechanism provides for piercing the laminate and comprises an internal channel for fluid communication, and may have an abrasive protrusions at the tip for piercing or abrading the skin surface to aid in generating a diagnostic response. The unit dose or doses may be housed in devices that provide for administration of the test material to the subject wherein the applicator section may contain protrusions for piercing or abrading the skin of a subject.
    Type: Application
    Filed: August 28, 2013
    Publication date: May 7, 2015
    Applicant: Mystic Pharmaceuticals, Inc.
    Inventors: Timothy R. Sullivan, Jeff Gjersten, Jesse Hancock
  • Patent number: 9011350
    Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: April 21, 2015
    Assignee: Lincoln Diagnostics, Inc.
    Inventors: Gary L. Hein, Jr., Douglas S. Hein
  • Publication number: 20150025412
    Abstract: An allergy skin test kit includes a template having puncture site indicators and a computer-readable storage medium storing allergy test information that associates the puncture site indicators of the template with template locations or test substance indicators. A method of performing an allergy skin test includes providing a template having puncture site indicators. Allergy test information that associates the puncture site indicators of the template with template locations or test substances identifiers is obtained. Image data corresponding to a test area on the skin of a test subject obtained and image regions corresponding to the puncture site indicators of the template are identified. Test results corresponding to the image regions are determined based, at least in part, on the allergy test information.
    Type: Application
    Filed: July 22, 2014
    Publication date: January 22, 2015
    Inventors: Sherwin A. Gillman, Alfredo Jalowayski
  • Publication number: 20140276196
    Abstract: An allergy testing device is formed by a blister pack containing a series of collapsible chambers each associated with an allergen and a lancet. The allergy testing device may be placed adjacent to a patient's skin and actuated by applying pressure to the collapsible chambers to open the chambers and release the reagents contained therein. The lancets deliver the allergen to the skin. The allergy testing device may apply marking to the skin to allow accurate measurement of the allergy testing results.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: ALLERGY DEVICES, INC.
    Inventors: Mark Q. Niederauer, Patrick Strauss
  • Publication number: 20140276197
    Abstract: A system, a method, and an apparatus are described herein for determining skin test sensitivities. A first skin test to evaluate a patient's skin reaction to one or more allergens may he performed. After measurements are taken of any reactions to the first skin test, a second skin test may be performed based on the results of the first skin test. Based on the results of the second test, an appropriate treatment endpoint for the patient may be determined. A computer-implemented method may be used for determining skin test sensitivities that may guide a user through one or more appropriate test selection and treatment endpoint determinations.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: GREER LABORATORIES, INC.
    Inventors: TOM GRIER, DONNA REKKERTH, MARTY JOHNSON, TIFFANY AHLERS, CURTIS ANDREWS
  • Patent number: 8764675
    Abstract: An electrode for applying electric fields to a patient includes a plurality of ceramic elements (e.g., ceramic discs) that are designed to be positioned against the patient's skin. Electrical connections are made to the ceramic elements (e.g., using a flex circuit). Temperature sensors (e.g., thermistors) are preferably provided at at least some of the ceramic elements to sense the temperature at the skin beneath the ceramic elements, so that appropriate action can be taken if an overtemperature condition is detected.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 1, 2014
    Assignee: Novocure Ltd
    Inventor: Yoram Palti
  • Patent number: 8715203
    Abstract: An electrode for applying electric fields to a patient includes a plurality of ceramic elements (e.g., ceramic discs) that are designed to be positioned against the patient's skin. Electrical connections are made to the ceramic elements (e.g., using a flex circuit). Temperature sensors (e.g., thermistors) are preferably provided at at least some of the ceramic elements to sense the temperature at the skin beneath the ceramic elements, so that appropriate action can be taken if an overtemperature condition is detected.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: May 6, 2014
    Assignee: Novocure Limited
    Inventor: Yoram Palti
  • Patent number: 8597199
    Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: December 3, 2013
    Inventors: Ziv Harish, Isaac Rubinstein, Ehud Arbit, Russ Weinzimmer
  • Publication number: 20130289440
    Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 31, 2013
    Inventors: Gary L. Hein, JR., Douglas S. Hein
  • Publication number: 20130245492
    Abstract: A driver for engaging and dispensing fluid from a sealed, prefilled syringe is provided. The driver includes a body and a rotating actuator configured to engage a plunger of the prefilled syringe. The driver is configured such that rotation of the rotating actuator relative to the body imparts both rotational movement and axial movement to a plunger of the prefilled syringe resulting in ejection of fluid from the prefilled syringe.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 19, 2013
    Applicant: SMARTHEALTH, INC.
    Inventors: Karl-Michael Klenk, Curtis P. Hamann, Bryan Richard Falk
  • Publication number: 20130231583
    Abstract: The present invention discloses methods, devices and systems for intradermal delivery comprising injection delivery guide devices as described herein. An injection delivery guide device may comprise a carrier member and at least one indentation applicator. Such methods, devices and systems are useful in intradermal administration of solutions comprising active agents.
    Type: Application
    Filed: February 28, 2013
    Publication date: September 5, 2013
    Inventor: Donna Rekkerth
  • Patent number: 8469900
    Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: June 25, 2013
    Assignee: Lincoln Diagnostics, Inc.
    Inventors: Gary L. Hein, Jr., Douglas S. Hein
  • Publication number: 20130138013
    Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.
    Type: Application
    Filed: November 30, 2011
    Publication date: May 30, 2013
    Applicant: LINCOLN DIAGNOSTICS, INC.
    Inventors: Gary L. Hein, JR., Douglas S. Hein
  • Publication number: 20130052139
    Abstract: A method and a kit for quantification of at least one predictor promoting at least one multifactorial disease, intended for use in assessment of the risk for developing or progression of the at least one multifactorial disease for a subject are disclosed. The kit comprises a plurality of reservoir units (320), each reservoir unit (320) being arranged to releasably retain a skin irritation agent adapted to provoke an unspecific inflammatory response of skin The kit comprises an estimation unit adapted to estimate a quantification of the at least one predictor on basis of an assessment of the at least one predictor performed by a user on basis of an assessment of the degree of severity of the inflammatory response to the skin irritation agent at each of a plurality of skin sites according to a predetermined inflammatory response criteria performed by the user and relative impact of the at least one predictor on the progress of the at least one multifactorial disease.
    Type: Application
    Filed: December 30, 2009
    Publication date: February 28, 2013
    Inventor: Sven Lindskog
  • Patent number: 8386027
    Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: February 26, 2013
    Assignee: Echo Therapeutics, Inc.
    Inventors: Han Chuang, Juan P. Eslava, James P. Hurley, Debashis Ghosh, Keith Krystyniak, Scott C. Kellogg
  • Patent number: 8363259
    Abstract: A method is described for producing printed patches to provide a plurality of color markings and high-contrast markings as aligned arrangements of fiducial points. The printed color markings facilitate optical image processing and the printed high-contrast markings facilitate high-contrast image processing. These fiducial points enable a visible area of interest to be located by a person and associated with relevant high-contrast imaging data. This method includes providing a patch; printing at least one arrangement of color markings on the patch; and printing at least one arrangement of high-contrast markings on the patch. According to further features of certain embodiments the markings are aligned, can designate the same point, or can be disjointed.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: January 29, 2013
    Assignee: Activiews Ltd.
    Inventor: Pinhas Gilboa
  • Patent number: 8317721
    Abstract: The present invention provides a device and method for skin testing. The device includes a handle assembly connected to a cylinder assembly having a first and second cylinder housing. Each cylinder housing is connected to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin and a socket assembly that is structured and operable to pivot the testing head to apply equal and even pressure to all the pins. Further, the method provides positioning the device tangent to the surface of the skin, and pivoting the testing head assembly horizontally to apply equal and even pressure to the pins.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 27, 2012
    Inventors: Patrick Win, Edwin A. Reed
  • Patent number: 8282571
    Abstract: The present invention provides a device for skin testing. The device includes a handle assembly connected to a cylinder assembly having two mutually parallel and spaced apart cylinder housings. Each cylinder housing connects to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin. Each head assembly has a collar and cooperating tip structured to pivot the testing head on two axes only and still apply even pressure to the pins. Each testing head readily inserts into the collar for usage and ejects promptly from the handle using a trigger mechanism. The cylinder housing construction minimizes accumulation of detritus therein.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 9, 2012
    Inventors: Patrick H. Win, Edwin A. Reed, IV
  • Publication number: 20120253224
    Abstract: An apparatus and method for making an apparatus for skin testing includes a housing with an opening which defines a field of view of a skin testing region, an image sensing apparatus, an illumination apparatus, a binding apparatus, and an image processing controller. The image sensing apparatus is positioned with respect to the housing to capture images in the field of view provided by the opening. The illumination apparatus is positioned within the housing to direct light towards a portion of the field of view provided by the opening. The binding apparatus detachably secures the housing over the skin testing region and maintains a fixed distance between the image sensing apparatus and the skin testing region. The controller is configured to analyze test samples sites in each of the captured images from the image sensing apparatus and provide a skin test result for each of the test sample sites.
    Type: Application
    Filed: October 13, 2011
    Publication date: October 4, 2012
    Applicant: SENSIVIDA MEDICAL TECHNOLOGIES, INC.
    Inventors: Jose Mir, John Spoonhower, John A. Agostinelli, John Squilla
  • Publication number: 20120101406
    Abstract: The present invention provides a device for skin testing. The device includes a handle assembly connected to a cylinder assembly having two mutually parallel and spaced apart cylinder housings. Each cylinder housing connects to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin. Each head assembly has a collar and cooperating tip structured to pivot the testing head on two axes only and still apply even pressure to the pins. Each testing head readily inserts into the collar for usage and ejects promptly from the handle using a trigger mechanism. The cylinder housing construction minimizes accumulation of detritus therein.
    Type: Application
    Filed: December 30, 2011
    Publication date: April 26, 2012
    Inventors: PATRICK H. WIN, Edwin A. Reed, IV
  • Publication number: 20120089048
    Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.
    Type: Application
    Filed: October 11, 2010
    Publication date: April 12, 2012
    Inventors: Ziv Harish, Isaac Rubinstein, Ehud Arbit, Russ Weinzimmer
  • Patent number: 8136941
    Abstract: A nose pad for supporting eyeglasses on a nose is disclosed. The nose pad includes a first surface and a second surface, the second surface opposing the first surface and including a contact portion configured to contact a wearer's nose. In an embodiment, the first surface includes a first outer edge portion, a second outer edge portion, and a central portion that is provided between the first outer edge portion and the second outer edge portion. In an embodiment, the first outer edge portion, the second outer edge portion, and the central portion are configured so that light directed at the first surface and passing through the second surface is dispersed so that the light is not concentrated on a wearer's nose.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: March 20, 2012
    Assignee: Hardisty Optical Group, LLC
    Inventor: James Melvin Slicker
  • Patent number: 8100830
    Abstract: The invention relates to new non-therapeutic methods allowing the level of skin neurosensitivity and/or the state of neurosensorial skin reactivity of an individual to be evaluated by applying a peripheral nervous system stimulant to one skin area, the method being implemented under conditions of safety and comfort acceptable for the user, irrespective of his or her skin type.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: January 24, 2012
    Assignee: Societe l'Oreal S.A.
    Inventors: Olivier De Lacharrière, Gilles Rubinstenn, Roland Jourdain
  • Patent number: 8084268
    Abstract: A substrate is filled with a reagent that presents a stable free radical character, and that is capable of producing a visible reaction in the presence of at least one free radical scavenger analyte of the skin.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: December 27, 2011
    Assignee: L'Oreal
    Inventors: Francis Pruche, Quang Lan Nguyen, Jean-Pascal Hirt
  • Publication number: 20110306898
    Abstract: Methods and items useful at least therein are provided for IBS related testing and treatment. Disclosed is a patch useful in determining if one or more test materials can cause allergic contact dermatitis in a patient. A kit containing information on use and that may include such a patch and/or test material(s) is also disclosed. A method of IBS related testing including performing skin patch testing on a patient presenting IBS symptoms using at least one test material that can cause allergic contact dermatitis is provided. A method for the treatment of IBS which includes limiting the intake by a patient presenting IBS symptoms of at least one material that gives a positive skin patch test result in the patient is also disclosed.
    Type: Application
    Filed: June 9, 2010
    Publication date: December 15, 2011
    Inventor: Michael Stierstorfer
  • Publication number: 20110282236
    Abstract: Test methods for assessing irritation of portions of skin and/or assessing inhibition and/or reduction of such irritation are provided.
    Type: Application
    Filed: July 28, 2011
    Publication date: November 17, 2011
    Inventor: Miranda Aref Farage
  • Publication number: 20110270122
    Abstract: An allergy testing system includes encapsulated allergens, a microneedle array, and an activation system coupled to the microneedle array and the encapsulated allergens such that the encapsulated allergens are moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is also disclosed. Penetration of one or more microneedles into a skin of the patient is caused. Each of the penetrations into the skin is exposed with an allergen from each of the one or more microneedles. One or more images are captured of each of the penetrations into the skin. Each of the captured images are analyzed to assess the degree of reaction to the specific allergen. Allergic reactivity data is output for at least one of the allergens.
    Type: Application
    Filed: April 5, 2011
    Publication date: November 3, 2011
    Applicant: INFOTONICS TECHNOLOGY CENTER, INC.
    Inventors: Jose Mir, Dennis Roland Zander
  • Publication number: 20110264003
    Abstract: A test chamber for epicutaneous patch test units is provided. The test chamber is formed of a multilayer material including at least one absorbent layer and at least one barrier layer. The test chamber is adapted to contain a liquid or petrolatum-based allergen. The absorbent layer absorbs the liquid or petrolatum-based allergen, while the barrier layer prevents the allergen from migrating out of the test chamber.
    Type: Application
    Filed: April 22, 2010
    Publication date: October 27, 2011
    Applicant: SMARTHEALTH, INC.
    Inventor: Curtis P. Hamann
  • Publication number: 20110118624
    Abstract: The present invention provides a device and method for skin testing. The device includes a handle assembly connected to a cylinder assembly having a first and second cylinder housing. Each cylinder housing is connected to at least one testing head assembly that includes a plurality of pins having a plurality of tips positionable against the skin and a socket assembly that is structured and operable to pivot the testing head to apply equal and even pressure to all the pins. Further, the method provides positioning the device tangent to the surface of the skin, and pivoting the testing head assembly horizontally to apply equal and even pressure to the pins.
    Type: Application
    Filed: October 14, 2010
    Publication date: May 19, 2011
    Inventors: Patrick Win, Edwin A. Reed
  • Patent number: 7942827
    Abstract: An allergy testing system includes encapsulated allergens, a microneedle array, and an activation system coupled to the microneedle array and the encapsulated allergens such that the encapsulated allergens are moved into contact with a subject as the microneedle array is moved from a resting position to a penetrating position. A method for determining a degree of reaction to one or more allergens by a patient in a minimally invasive manner is also disclosed. Penetration of one or more microneedles into a skin of the patient is caused. Each of the penetrations into the skin is exposed with an allergen from each of the one or more microneedles. One or more images are captured of each of the penetrations into the skin. Each of the captured images are analyzed to assess the degree of reaction to the specific allergen. Allergic reactivity data is output for at least one of the allergens.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: May 17, 2011
    Assignee: Infotonics Technology Center, Inc.
    Inventors: Jose Mir, Dennis Roland Zander
  • Patent number: RE46823
    Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: May 8, 2018
    Inventors: Ziv Harish, Isaac Rubinstein, Ehud Arbit, Russ Weinzimmer