Abstract: This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.

Abstract: A rectal drainage appliance is disclosed comprising a tubular element having an inflatable balloon at a distal end for anchoring the appliance in the rectum. The appliance includes one or more of: (i) first and second auxiliary lumens communicating with the inflatable balloon to provide independent inflation and pressure monitoring paths coupled to the balloon; (ii) a pressure state indicator defined by a mechanical element configured to flip between first and second states or shapes responsive to sensed pressure; and (iii) a collapsible auxiliary lumen larger than the inflation lumen, and configured to permit admission of irrigation fluid. The pressure state indicator may also be used in intestinal drains.

Abstract: A flexible printed circuit and a manufacturing method thereof, an electronic device module and an electronic device are provided.

Abstract: An intracranial pressure monitoring device includes a housing defining a first internal chamber, a plurality of strain gauges disposed on an inner surface of a diaphragm defined by a wall of the first internal chamber, a device for generating orientation signals, and circuitry coupled to the plurality of strain gauges and to the device. The circuitry is configured to generate intracranial pressure data from signals received from the plurality of strain gauges, generate orientation data based on the orientation signals received from the device, and store the intracranial pressure data and the orientation data in a computer readable storage such that the intracranial pressure data and orientation data are associated with each other.

Abstract: In part, the disclosure relates to computer-based methods, devices, and systems suitable for performing intravascular data analysis and measurement of various types of data such as pressure and flow data. The disclosure relates to probes and methods suitable for determining an event in a cardiac cycle such as flow threshold such as a peak flow, a fraction thereof, other intravascular parameters or a point in time during which peak flow or a change in one of the parameters occurs. An exemplary probe includes one or more of a pressure sensor, a resistor, a flow sensor and can be used to generate diagnostic data based upon measured intravascular and other parameters. In part, the disclosure relates to methods and systems suitable for determining a coronary flow reserve value in response to one or more of intravascular pressure and flow data or data otherwise correlated therewith.

Abstract: The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health. Certain implementations are directed to patients who require daily catheterization. The various embodiments have at least one tube coupled to a catheter, a pressure sensor, a pump, and a processor. Certain embodiments include a digital device with a software application capable of displaying the monitored readings.

Abstract: An integrated circuit includes a nexus and a first, a second, a third, and a fourth circuit board. Each of the first and second circuit boards is coupled to opposing sides of the nexus, and each of the third and fourth circuit boards is coupled to opposing sides of the second circuit board. The integrated circuit is transitionable between a first, open configuration, in which the first, second, third and fourth circuit boards and the nexus are substantially coplanar, and a second configuration, in which the first, second, third and fourth circuit boards and the nexus are coupled to one another to define a cavity therein.

Abstract: A system and method are provided for detecting air embolisms in lines for hemodynamic monitoring. In use, using a first sensor, one or more gas bubbles are detected within a first line for hemodynamic monitoring. In response to the detecting, a first clamp attached to the first line for hemodynamic monitoring is contracted.

Abstract: A capsule endoscope image receiver includes a receiving electrode unit that receives first and second differential signals from a capsule endoscope image transmitter through a human body communication channel, an analog amplifying unit that receives the first and second differential signals and outputs first and second amplified differential signals, and a signal restoring unit that receives the first and second amplified differential signals and restores image information. The analog amplifying unit includes a first amplifier that outputs the first amplified differential signal, a second amplifier that outputs the second amplified differential signal, and an input impedance that is connected between a first inverting input terminal of the first amplifier and a second inverting input terminal of the second amplifier and obtains a gain of differential signal amplification in which a high frequency component of the first and second amplified differential signals is greater than a low frequency component.

Abstract: A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material. A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material.

Abstract: A catheter can include a catheter main body and a sheath that covers the catheter main body and can move along the longitudinal axis with respect to the catheter main body. An operating unit can be disposed at a proximal end portion of the sheath and can move the sheath and the catheter main body with respect to one another. The catheter main body can include a slit on an outer peripheral surface of a distal end portion and can extend along the longitudinal axis from a slit distal end to a slit proximal end side. An outside diameter of the distal end portion of the catheter main body is larger than an inside diameter of a distal end portion of the sheath when the distal end portion of the catheter main body is housed in the sheath.

Abstract: Intravascular diagnosis apparatus and methods are disclosed. In one aspect of the disclosed technology, a intravascular diagnosis apparatus includes a monitoring guidewire and a display unit. The monitoring guidewire includes a core wire and a sensor disposed in a distal region of the core wire. The display unit includes a processor and a display screen, and is capable of receiving communication from the monitoring guidewire. The display unit is configured to perform computations using the processor based on communications received from the monitoring guidewire and is configured to display information on the display screen based on the computations. The display unit can be configured to be disposed after a predetermined number of uses or after a predetermined duration of use.

Abstract: A sample collection and processing apparatus includes a tissue processing cassette and a biopsy device. The tissue processing cassette is sized to be used in a pathology laboratory for purposes of dehydrating, embedding and sectioning. The tissue processing cassette has at least one distal opening through which tissue samples are received and has a floor with a plurality of openings. The biopsy device has a cassette holder adapted to receive the tissue processing cassette. The cassette holder has a fluid path adapted to be coupled to a vacuum source and in fluid communication with the interior of the tissue processing cassette through the openings of the floor such that vacuum from the vacuum source facilitates the transfer of the cut tissue samples into the received tissue processing cassette.

Abstract: A catheter hub assembly includes a body. A pressure sensor is disposed within the body to sense pressure within a catheter and communicating with the body. The body has a chamber formed therein having a predetermined volume. A stopper assembly, slideably moves to engage the body forming a gastight seal within the chamber for pushing a column of gas ahead of the stopper assembly as the stopper assembly moves from a first position to a second position.

Abstract: A low-profile intercranial device including a low-profile static cranial implant and a functional neurosurgical implant. The low-profile static cranial implant and the functional neurosurgical implant are virtually designed and interdigitated prior to physical assembly of the low-profile intercranial device.

Abstract: In some examples, a tissue compression device includes a base including a major surface configured to engage a dorsal surface of a hand of a patient, a flexible backing adjustably mechanically connected to the base and configured to engage a palmar surface of the hand when the dorsal surface of the hand is engaged with the base, and an expandable member mechanically connected to the flexible backing. The expandable member is configured to be positioned over an ulnar region of the patient when the palmar surface of the hand is engaged with the flexible backing and the dorsal surface of the hand is engaged with the base, such that inflation of the expandable member may apply pressure to tissue near the ulnar artery of the patient.

Abstract: A medical instrument includes a snake wrist structure further including: a first joint disk having a first rim having a first tooth slot and a first toothed gear with the first tooth slot opposite the first toothed gear along the first rim; and a first strut having a first slot bearing and a first hole bearing connected by a first connection strut with the first slot bearing in the first tooth slot.

Abstract: Provided is an implant, including a chamber having an interior radius wherein the interior radius has a flange, a cover slip, a cup, a setting member, a securing member, a resistance member, and an opposing member, wherein the cover slip, cup, resisting member, and setting member are attached to one another, the setting member sets on a flange and the securing member secures the setting member to the flange, the resistance member includes a flexibility and a longitudinal axis with a length wherein the flexibility permits modification of the length, and the opposing member sets a minimum length of the longitudinal axis. Also provided is a method of using said implant including affixing the chamber to a skull of a mammal.

Abstract: A device that can be placed within or near the cranial vault that fluctuates in size in response to changes in CSF pressure is disclosed. The device diminishes in size when CSF pressures rise and increases in size as CSF pressures diminish. The device has the effect of reducing the flow of CSF occurring in the foramen magnum and provides an alternative to craniovertebral decompression in Chiari I patients. The device may have applications in other neurologic illnesses associated with abnormal CSF flow, such as Idiopathic Syringomyelia, Normal Pressure Hydrocephalus, and CSF dural leaks.

Abstract: Methods and devices to diagnose and treat fecal incontinence in females and males are provided. A multiple sensor-enabled catheter for positioning in a patient's rectum allows for the visualization and manipulation or positioning of an anatomical reference point(s) in the patient's body. A multiple sensor-enabled catheter for rectal insertion in a patient allows for the visualization and implementation of efficient and effective exercises to strengthen pelvic floor muscles.

Abstract: A hemostatic device includes a covering member for covering a dorsal side of a patient's hand, the covering member including a hole through which a puncture site on the hand where bleeding is to be stopped, is exposed. The hemostatic device further includes a pressing member configured to apply a compression force to the puncture site when the pressing member is positioned over the site and fixed to the covering member, a fixing member configured to fix the pressing member to the covering member, and a support member configured to support the hand when the pressing member applies the compression force to the puncture site. At least a portion of the support member faces the hole portion with the hand interposed therebetween, when the covering member is disposed on the dorsal side of the hand.

Abstract: Systems and methods for measuring phase dynamics and other properties (e.g. intracranial pressure) are disclosed. For example, the system may generate a reference waveform and a measurement waveform using digital synthesizers, each waveform having an identical constant frequency but also a relative phase shift. Next, system may send a tone-burst, via a transducer, into a sample (e.g. a skull or a bonded material), and then receive a reflected tone-burst in response. Then, a phase difference between the received tone-burst and the measurement waveform may be determined with a linear phase detector. Next, the phase shift of the measurement waveform may be adjusted, by the determined phase difference, such that there is no longer any phase difference between the received tone-burst and the adjusted measurement waveform generated by the appropriate digital synthesizer. A similar adjustment may occur after subsequent tone-bursts, allowing accurate monitoring of continuously variable phase relationships.

Abstract: System for non-invasive measuring of an intracranial reserve space (ICRS) parameter of a mammalian subject, comprising a multi-frequency ultrasound probe configured, beginning at a start time, to emit and receive ultrasound waves into and from the subject's head and to produce a signal of brain tissue pulsation; an instrument configured to non-invasively partially occlude an internal jugular vein (IJV) starting at the start time and including a second ultrasound probe producing a second signal; and a computer system configured to receive the signal, the second signal and the start time, the computer system also configured, using one or more processors, to derive from the signal an intracranial brain tissue pulsation waveform and from the second signal images of the IJV, and to determine a length of time from the start time to a subsequent time at which the waveform is sufficiently compressed so as to exhibit a predefined decline in variability.

Abstract: A method for detecting evidence of a stroke in a patient may involve securing a volumetric integral phase-shift spectroscopy (VIPS) device to the patient's head, transmitting a first signal from a first transmitter of the VIPS device through a left hemisphere of the patient's brain to a receiver of the VIPS device, transmitting a second signal from a second transmitter of the VIPS device through a right hemisphere of the patient's brain to the receiver, and detecting the evidence of the stroke, with the VIPS device.

Abstract: An apparatus (10) for minimally-invasive, including non-invasive, prevention and/or treatment of hydrocephalus and method for use of the same are disclosed. In one embodiment of the apparatus (10), a housing (50) is sized for superjacent contact with a skull having a fontanel. Within the housing (50), a compartment (12) includes a pressure applicator (88), such as a fluid-filled bladder (22), under the control of a pressure regulator (14). The pressure applicator (88) is configured to selectively apply an external pressure to the fontanel. The compartment (12) includes a pressure sensor (90) configured to measure intracranial pulse pressure of the fontanel. Further, in one embodiment, the apparatus (10) can cause pulse pressure modulation by adjusting the intracranial pulse pressure via the pressure applicator (88). This enables a non-invasive measurement of the pulse pressure and modulation thereof in infants, for example.

Abstract: A coaxial draining tube, particularly for chest draining systems, includes an inner tube, which has a first opening, and an outer tube, which has a second opening. The inner tube is enclosed within the outer tube and has a smaller diameter than the second opening of the outer tube. The first and second tubes are mutually coupled by way of a supporting component and include one or more holes adapted to allow the passage of air from the chest cavity to the first opening of the inner tube and one or more holes adapted to allow the passage of liquids from the chest cavity to the second opening of the outer tube. The one or more holes are provided in the portion of the coaxial draining tube that is intended to be inserted in the chest cavity of a patient.

Abstract: A system and method for collecting operation data associated with a medical apparatus including an internal device implanted in a subject and an external device that is magnetically-coupled to and drives the internal device. The medical apparatus may be monitored to obtain raw data associated with the operation of the medical apparatus and one or more calculations may be performed on the raw data, wherein the raw data and/or calculated values may be associated with voiding frequency and voiding volume of the subject. A report may be generated from the raw data and/or calculated values. In addition, one or more signals may be sent to the external device and/or a docking station, or communicated by other means, to indicate to the subject that the operation of the medical apparatus should be altered.

Abstract: A method for delivering an immunotherapy agent to a tumor includes advancing the delivery device into a vessel of a patient, and infusing the agent under pressure into the vessel to penetrate the tumor. The delivery device prevents reflux of the agent toward non-treatment sites.

Abstract: Systems and methods for monitoring physiological parameters such as intracranial pressure (“ICP”), intracranial temperature, and subject head position are provided. In some embodiments, an implantable apparatus for measuring ICP can be implanted into a subject skull. The apparatus can comprise an implant body having a hermetically sealed chamber housing a gas at a reference pressure, and a pressure conduction catheter having a proximal end and a distal end, wherein the distal end is configured to extend into the brain through a burr hole in the skull and includes a plurality of ports. A barrier can cover the ports of the distal end of the pressure conduction catheter, wherein the barrier and pressure conduction catheter are filled with a number of gas molecules so that the barrier is not in tension in a predefined range of ICPs. The ports may also be configured such that a barrier is not necessary.

Abstract: Non-invasive measurement of intracranial pressure (ICP), for example mean ICP. A probe adjacent the head emits energy, such as ultrasound, and receives reflected signals. A processing unit derives ICP waveform from the signals. A pressure mechanism applies external pressure intermittently to outer surface of the head and incrementally increases the external pressure. The processing unit is configured to detect a decrease in amplitude of the ICP waveform (occurring in some embodiments only after an intermediate period of ICRS compensation), the processing unit configured to determine the ICP of the person from a sum of applied external pressures from a time of the initial value A1 until a final value at which the amplitude remains stable with additional increase in applied external pressure. In some cases, the final value is earlier than that but the processing unit extrapolates the sum to when the amplitude remains stable with additional increases in pressure.

Abstract: Ophthalmic surgical devices, systems, and methods for regulating aspiration from a patient's eye are provided. A vacuum pump in fluid communication with an aspiration line provides fluid aspiration from a vitreous chamber of the eye through the aspiration line. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the aspiration in response to changes in the IOP, such as by controlling the vacuum pump. The controller may determine whether a fluid infusion to the vitreous chamber through an infusion line is below a maximum infusion level, regulate the infusion in response to the IOP being below a threshold value and the infusion being below the maximum infusion level, and regulate the aspiration in response to the IOP being below the threshold value and the infusion being at or above the maximum infusion level.

Abstract: An imaging capsule configured to be swallowed to scan the gastrointestinal tract of a person from the inside, including a radiation source providing X-Ray and gamma radiation for scanning the gastrointestinal tract, a pressure sensor for measuring the internal pressure in the imaging capsule; and wherein the imaging capsule is configured to control the emission of radiation from within the imaging capsule responsive to the measurements of the pressure sensor.

Abstract: A medical system includes a medical fluid pumping machine comprising a pressure sensor, a medical fluid line set comprising a fluid line in fluid communication with a fluid passage formed between a diaphragm and a base, the medical fluid line set being configured to be connected to the medical fluid pumping machine in a manner such that the diaphragm of the medical fluid line set aligns with the pressure sensor of the medical fluid pumping machine, and a member configured to apply a positive force to the pressure sensor when the medical fluid line set is connected to the medical fluid pumping machine and the fluid passage is at atmospheric pressure.

Abstract: A shunt including an implantable housing having a proximal end and a distal end. A pressure sensitive valve is contained within the housing at a position between the proximal end and the distal end, and the pressure sensitive valve is capable of controlling a flow of fluid between the fluid inlet port and the fluid outlet port. The shunt further including a sensor assembly fluidly coupled to the pressure sensitive valve, wherein the sensor assembly is mechanically actuated and capable of detecting the flow of fluid through the pressure sensitive valve. A condition of the shunt can be detected by detecting a flow of fluid through the shunt and generating a signal indicative of a period of fluid flow through the implantable shunt based on the detecting. The signal can be output to an external device capable of determining, from the signal, whether the shunt is malfunctioning.

Abstract: Wireless intracranial monitors are provided. The wireless intracranial monitors comprise a main body, a wireless transceiver, a processing module, and a sensing module, in which the sensing module contains a catheter. On the catheter, a pressure sensor is configured to detect deformation of the catheter or a diaphragm connected to the pressure sensor. The detected deformation is then transmitted to the processing module through an in-catheter wire.

Abstract: A bio-pressure sensor system is disclosed, comprising a first sensor configured to provide a reference pressure measurement and second sensor configured to measure a fluid pressure within a human body. The bio-pressure sensor system also comprises a first reference element and second reference element. The first and second sensors share the first reference element. The second reference element is coupled to the first sensor and configured to provide a reference pressure. The first and second sensors each comprise independent output signals.

Abstract: A system capable of monitoring a replaceable component is provided. The system includes a controller for controlling operation of the system; programming instructions according to which the system is configured to: accept input of a viable life for the component, calculate an accumulated amount of distress experienced by the component based on each set of previously collected use data associated with each previous use of the component, and determine, based in part on the accumulated amount of distress, a used portion of the viable life that the component has experienced as a result of the previous use(s) thereof and an unused portion of the viable life; and a feedback device configured to provide to an operator of the system an indication of at least one of the unused and used portions of the viable life of the component. Methods of monitoring a replaceable component of a system are also provided.

Abstract: The present invention provides strategies to integrate adsorption and liquefaction techniques to separate hydrocarbon feed mixtures into purified light and heavy components, respectively. Initially, the hydrocarbon stream is separated into a light and heavy stream. The light stream can be integrated into a natural gas product. The heavy stream is partially liquefied. A first gas liquid separation of the partially liquefied heavy stream at an elevated pressure separates the liquid heavy stream from a methane-containing gas. The rejected methane component, which generally will include some rejected C2 and C3+ material, can be recycled to be combined with the feed mixture for re-processing. A further aspect of the strategy is then to practice at least one additional gas-liquid separation of the separated liquid heavy stream at a lower pressure effective to help further resolve the liquid heavy stream from C2-containing gas.

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract: A device for detecting spatial differences in fluid level changes in a tissue of a patient may include a support structure for securing the device to a body part of the patient, a processing element operably connected to the support structure, a wireless networking interface operably connected to the support structure and in communication with the processing element and an external computing device via a network, a first transmission module operably connected to the support structure and in communication with the processing element, a second transmission module and a third transmission module operably connected to the support structure and in communication with the processing element. When activated, the first transmission module transmits a first time varying magnetic field through the tissue of the patient. The second and third transmission modules, which are spatially separated from one another, receive first and second versions, respectively, of the first time varying magnetic field.

Abstract: Systems and methods for measuring and damping forces within autoinjectors in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an injection system comprises a syringe disposed within a housing, the syringe having a first end and a second end; a needle disposed at the second end of the syringe; a plunger disposed at the first end of the syringe and configured to move toward the second end of the syringe; a stopper disposed between the plunger and the second end of the syringe; a first damper disposed between the plunger and the stopper, such that the first damper is capable of damping a first event occurring between the plunger and the stopper; and a second damper disposed at the second end of the syringe, such that the second damper is capable of damping a second event occurring at the second end of the syringe.

Abstract: Non-invasive measurement of intracranial pressure (ICP), for example mean ICP. A probe adjacent the head emits energy, such as ultrasound, and receives reflected signals. A processing unit derives ICP waveform from the signals. A pressure mechanism applies external pressure intermittently to outer surface of the head and incrementally increases the external pressure. The processing unit is configured to detect a decrease in amplitude of the ICP waveform (occurring in some embodiments only after an intermediate period of ICRS compensation), the processing unit configured to determine the ICP of the person from a sum of applied external pressures from a time of the initial value A1 until a final value at which the amplitude remains stable with additional increase in applied external pressure. In some cases, the final value is earlier than that but the processing unit extrapolates the sum to when the amplitude remains stable with additional increases in pressure.

Abstract: A measurement system and method for measuring at least one parameter in a body tissue comprise at least one measurement device to be applied to the body, an optical unit for emitting light waves, wherein at least one wavelength of the light waves lies in the region of the absorption of a body parameter, at least one light guide between the optical unit and the measurement device in order to transmit light waves, and an evaluation unit for evaluating measurement waves. Light waves emitted by the optical unit can be beamed into an optical measurement volume in the body tissue by means of the measurement device, and measurement waves received by the measurement device from the measurement volume can be transmitted from the body tissue to the evaluation unit.

Abstract: In some examples, a device includes processing circuitry configured to determine a set of correlation coefficient values for first and second physiological parameters. The processing circuitry is further configured to determine a metric of the correlation coefficient values for a first plurality of bins and for a second plurality of bins, wherein each bin of the first plurality has a first bin parameter and each bin of the second plurality of bins has a second bin parameter different than the first bin parameter. The processing circuitry is also configured to determine a composite estimate of a limit of autoregulation of the patient based on the metric for the first plurality of bins and the metric for the second plurality of bins. The processing circuitry is configured to determine an autoregulation status based on the composite estimate and output, for display via the display, an indication of the autoregulation status.

Abstract: In some examples, a device includes processing circuitry configured to determine a set of correlation coefficient values for values of first and second physiological parameters. The processing circuitry is further configured to determine that the first physiological parameter changes rapidly in a particular time period. The processing circuitry is configured to select a correlation coefficient value associated with the particular time period and determine an updated value of the selected correlation coefficient value in response to determining that the first physiological parameter changes rapidly in a particular time period. The processing circuitry is further configured to determine an estimate of a limit of autoregulation of the patient based on the set of correlation coefficient values and the updated value. The processing circuitry is configured to determine an autoregulation status based on the estimate of the limit of autoregulation and output, for display, an indication of the autoregulation status.

Abstract: An intrauterine pressure-sensing catheter for detecting pressure changes within the uterus of a patient is disclosed having a tube with a primary lumen extending from a proximal end to a distal end of the elongate tube. A monitor lumen is positioned within the elongate tube between the primary lumen and a wall of the elongate tube and extends from a proximal end of the elongate tube to a distal end of the elongate tube. A pressure-compliant balloon is disposed about an exterior of the elongate tube adjacent a distal end tip. A sleeve is slidably mounted on an exterior of the elongate tube and disposed over the pressure-compliant balloon during insertion of the pressure-sensing catheter within the patient. The distal end tip is configured to prevent movement of the sleeve over the tip and is further configured to provide a zone of protection for the pressure-compliant balloon.

Abstract: In some examples, a catheter may include a catheter body, a first expandable member, and a second expandable member. The catheter body may define a first lumen, a second lumen, a delivery port, and a surface extending from the delivery port into the first lumen. The first lumen may define a first central longitudinal axis. The second lumen may define a second central longitudinal axis spaced from the first central longitudinal axis in a direction orthogonal to the second central longitudinal axis. The delivery port may be in fluid communication with the first lumen. The surface extending from the delivery port into the first surface may be oriented at an obtuse or acute angle relative to the first central longitudinal axis.

Abstract: A pressure sensor assembly for use in sensing a pressure of a process fluid in a high temperature environment includes an elongate sensor housing configured to be exposed to the process fluid and having a cavity formed therein. A pressure sensor is positioned in the cavity of the elongate sensor housing. The pressure sensor has at least one diaphragm that deflects in response to applied pressure and includes an electrical component having an electrical property which changes as a function of deflection of the at least one diaphragm which is indicative of applied pressure. A flexible membrane in contact with the at least one diaphragm is disposed to seal at least a portion of the cavity of the sensor housing from the process fluid and flexes in response to pressure applied by the process fluid to thereby cause deflection of the at least one diaphragm.

Abstract: A catheter for measuring pressure in the urinary tract of a patient includes a catheter body having a proximal and distal end. A plurality of lumens is formed in the catheter body, and an adaptor is coupled to the proximal end of the catheter body. The adaptor includes a port for each lumen. A first pressure sensor, typically including a balloon, is fluidically coupled to a first lumen and is configured and positioned to measure pressure in a urethra of the patient. A second pressure sensor, also typically including a balloon, is fluidically coupled to a second lumen and is configured and positioned on the catheter body to measure pressure in a bladder of the patient. An expandable retention member, which may be coupled to a third lumen, is positioned on the catheter body between the first and second expandable pressure sensors so that the catheter body may be retained at a selected location in the urinary tract to properly position the fluid pressure sensors in the bladder and urethra, respectively.

Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.