Ultrasonic Patents (Class 601/2)
  • Patent number: 11406315
    Abstract: A non-invasive system for monitoring brain trauma, the system comprising: a plurality of spaced apart brainwave sensors configured to monitor brainwaves of a user of the system; one or more force determination sensors, configured to determine an amount of force exerted on the user's head; and a processing unit configured to: obtain a plurality of brainwave readings from the brainwave sensors and a plurality of force readings from the force determination sensors; provide a notification upon the force readings indicating that the amount of force exerted on the user's head exceeds a threshold or upon the brainwave readings indicating an abnormal brain activity.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: August 9, 2022
    Inventor: Elliot Steven Finkelstein
  • Patent number: 11406848
    Abstract: The present disclosure relates to an ultrasound therapy device using high-intensity focused ultrasound (HIFU) and a control method thereof. The ultrasound therapy device comprises: an array type HIFU converter having a plurality of HIFU conversion elements; and a control unit for performing a control to treat tissues in a focusing area by selecting and driving some of the HIFU conversion elements of the array type HIFU converter and irradiating ultrasound signals to an object through the driven active conversion elements to generate heat energy, wherein, after an elapse of a predetermined time period, the control unit drives a combination of other conversion elements as new active conversion elements in replacement of the active conversion elements.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: August 9, 2022
    Inventors: Tai-Kyong Song, Pilsu Kim, Jiwon Park, Sua Bae
  • Patent number: 11389372
    Abstract: A method of modulating glandular secretions by administering acoustic shock waves to a reflexology zone has been discovered. In one preferred embodiment, a treatment method achieves one or more of a) modulating blood sugar levels, b) stimulating insulin production levels or c) normalizing A1C levels by administering acoustic shock waves to a reflexology zone or region of a patient. The treatment method further has the steps of: activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves; subjecting the reflexology zone to acoustic shock waves stimulating the pancreas to have a modulated response wherein the modulated response is one of an adjustment in blood sugar levels or insulin production and release or normalizing A1C levels which increases low level output, decreases high level output or stabilizes erratic output; and wherein the emitted acoustic shock waves are focused or unfocused.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: July 19, 2022
    Assignee: Softwave Tissue Regeneration Technologies, LLC
    Inventors: John F. Warlick, John Patrick Finney, Janey Lynn Watts
  • Patent number: 11389263
    Abstract: Surgical instruments include a first drive assembly having a first drive gear and a lockout mechanism positioned for releasable engagement with the first drive assembly to inhibit rotation of the first drive gear. The lockout mechanism includes a pawl and an actuator for moving the pawl from a first position in engagement with the first drive gear to a second position spaced from the first drive gear.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: July 19, 2022
    Assignee: Covidien LP
    Inventors: Justin Williams, Joseph Eisinger, Michael Ingmanson, Kelly Azeredo, Thomas Wingardner, David Valentine, Jr.
  • Patent number: 11375979
    Abstract: Disclosed is an ultrasonic probe having an improved heat radiation capability. The ultrasonic probe includes a transducer module configured to transmit and receive an ultrasonic signal, a housing configured to accommodate the transducer module, a cable connected to the transducer module inside the housing and drawn from the inside of the housing to the outside of the housing through an end of the housing, a bending device configured to cover the cable and connected to the end of the housing to receive heat, a strain relief configured to surround the bending device and including a heat radiation groove extending along a circumferential direction of the cable, and a heat radiation fin inserted into the heat radiation groove such that one end thereof is in contact with the bending device and the other end thereof is in contact with outside air.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: July 5, 2022
    Inventors: Gil Ju Jin, Ji Ho Gu
  • Patent number: 11364079
    Abstract: A shock wave generating device includes an optical fiber and a reflective part, and is configured to reflect and converge the shock wave generated inside the reflective part to an outside of the reflective part. The reflective part includes: a reflector having a concave surface having a cut surface-of-revolution shape, and a through hole, which is formed coaxially with a rotating axis of the concave surface, and into which the optical fiber is to be inserted; a sealing body configured to seal an opening portion of the concave surface; and a liquid to be charged between the concave surface and the sealing body. The optical fiber has a distal end arranged at a position on a rear side of a focal point of the concave surface, at which the shock wave reflected by the concave surface is convergeable outside the reflective part.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: June 21, 2022
    Inventors: Hiroaki Yamamoto, Kazuyoshi Takayama, Hiroaki Shimokawa
  • Patent number: 11351075
    Abstract: A convertible patient support apparatus includes a patient support bed and a removable patient contact disposed in a hole in the patient support bed. The hole is defined by a support frame. A static membrane is attached to the support frame. One of a plurality of removable patient contacts can be removably attached to the support frame to convert the convertible patient support apparatus based on the patient and/or therapy.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: June 7, 2022
    Assignee: Profound Medical Inc.
    Inventors: Antti Matias Syrjä, Aaro Tuominen, Raimund Christopher Wieland Jung
  • Patent number: 11338156
    Abstract: Systems and methods for noninvasive tissue tightening are disclosed. Thermal treatment of tissues such as superficial muscular aponeurosis system (SMAS) tissue, muscle, adipose tissue, dermal tissue, and combinations thereof are described. In one aspect, a system is configured for treating tissue through delivery of ultrasound energy at a depth, distribution, temperature, and energy level to achieve a desired cosmetic effect.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: May 24, 2022
    Assignee: Guided Therapy Systems, LLC
    Inventors: Michael H. Slayton, Peter G. Barthe, Inder Raj S. Makin, Brian D. O'Connor
  • Patent number: 11318243
    Abstract: In one example embodiment, a system for treating a tissue site is disclosed that may comprise a manifold including a non-porous film having a plurality of closed cells defined by a sealed region perforated with apertures extending through the sealed region, wherein the manifold is adapted to contact the tissue site. The system may further comprise a cover adapted to provide a fluid seal between a therapeutic environment including the manifold proximate one side of the cover and a local external environment on the other side of the cover. In one embodiment, the plurality of closed cells is adapted to form distal channels with the cover and the apertures are adapted to provide fluid communication between the distal channels and the tissue site. The system may further comprise a negative-pressure source fluidly coupled to the therapeutic environment and adapted to provide negative pressure through the distal channels and the apertures to the tissue site.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: May 3, 2022
    Assignee: KCI Licensing, Inc.
    Inventors: Timothy Mark Robinson, Christopher Brian Locke
  • Patent number: 11318330
    Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: May 3, 2022
    Inventors: Christopher Michael Puleo, Lakshmi Sireesha Kaanumalle, Victoria Eugenia Cotero, John Frederick Graf
  • Patent number: 11298568
    Abstract: Systems and methods for ablating tissue include an ablation device having an energy source and a sensor. The energy source provides a beam of energy directable to target tissue, and the sensor senses energy reflected back from the target tissue. The sensor collects various information from the target tissue in order to facilitate adjustment of ablation operating parameters, such as changing power or position of the energy beam. Gap distance between the energy source and target tissue, energy beam incident angle, tissue motion, tissue type, lesion depth, etc. are examples of some of the information that may be collected during the ablation process and used to help control ablation of the tissue.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: April 12, 2022
    Assignee: Auris Health, Inc.
    Inventors: Hira V. Thapliyal, David A. Gallup, James W. Arenson
  • Patent number: 11284841
    Abstract: An implant sized and shaped to be endovascularly delivered to the middle meningeal artery includes a carrier that carries a payload between first and second ends thereof. An anchor mechanism associated with the implant transitions into a swollen state in response to exposure to bodily fluids. In the swollen state, said anchor mechanism anchors the implant to the middle meningeal artery. Before or during the transition, the anchor mechanism permits endovascular delivery of the implant to the middle meningeal artery.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: March 29, 2022
    Assignee: Tufts Medical Center, Inc.
    Inventors: Adel M. Malek, Carl Heilman
  • Patent number: 11278745
    Abstract: Disclosed are methods and devices for treatment of subcutaneous fat by simultaneously transdermally inducing both ultrasonic transverse vibrations and ultrasonic longitudinal vibrations in subcutaneous tissue, for example for reduction of subcutaneous fat.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: March 22, 2022
    Inventors: Alexander Britva, Alexander Dverin, Yevgeny Pens, Joseph Lepselter, Ziv Karni, Shahar Tsurgil, Ohad Toledano
  • Patent number: 11253729
    Abstract: An external ultrasound generating treating device (12) to induce spinal cord and/or spinal nerve treatment comprises at least two sub-arrays of ultrasound generating treatment transducers, a left sub-array (20iL) being located on a left lateral side and a right sub-array (20iR) being located on a right lateral side of the central longitudinal axis (Ai). The device comprises a support structure (32) having at least one module (34i) comprising a left lateral section (34iL) and a right lateral section (34iR). The support structure (32) maintains, in use of the device, a constant distance and a constant relative angular orientation around the central longitudinal axis (Ai) between the first left and first right treatment transducers or set of treatment transducers (20iL, 20iR). Also disclosed is an apparatus including the external ultrasound generating treating device (12) and methods of its use.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: February 22, 2022
    Inventor: Alexandre Carpentier
  • Patent number: 11250675
    Abstract: A sensor system includes an actuator, an accelerometer coupled with the actuator, a rigid member, a transducer, and one or more processors. The actuator generates motion. The accelerometer outputs an acceleration signal responsive to at least the motion of the actuator. The rigid member extends from a first end coupled with the accelerometer to a second end. The transducer is coupled with the second end of the rigid member. The transducer can be configured to couple with a load, and can output a force signal responsive to at least a portion of the motion of the actuator transmitted to the transducer via the rigid member. The one or more processors determine a mechanical impedance of the load based at least on the acceleration signal and the force signal.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: February 15, 2022
    Assignee: Facebook Technologies, LLC
    Inventors: Morteza Khaleghimeybodi, Chuming Zhao, Scott Porter
  • Patent number: 11241586
    Abstract: Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: February 8, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Li-Huei Tsai, Anthony James Martorell, Ho-Jun Suk, Ed Boyden
  • Patent number: 11241592
    Abstract: Disclosed is a method and apparatus for more locally stimulating a desired stimulation region in a predetermined part of an object, the apparatus including a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object, a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object, and a controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: February 8, 2022
    Inventors: Hyunjoo Lee, HyungGuk Kim, Seongyeon Kim
  • Patent number: 11235178
    Abstract: Embodiments of the present disclosure relate to techniques for facilitating personalized neuromodulation treatment protocols. In one embodiment, a predetermined treatment position of an energy application device is used to guide future treatments for the patient. In one embodiment, a position of the energy application device relative to the predetermined treatment position is determined. In one embodiment, a total dose of ultrasound energy applied to the region of interest is determined.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: February 1, 2022
    Inventors: Christopher Michael Puleo, Yang Zhao, Kirk Dennis Wallace, Ying Fan, Jeffrey Michael Ashe, David Andrew Shoudy
  • Patent number: 11221672
    Abstract: The present invention provides an asymmetric EEG-based coding and decoding methods for BCIs, the BCI system includes an evoked stimulus module, an acquisition module and an EEG signal data set including a training set Xk and a testing sample Y, and an EEG signal decoding module; the evoked stimulus module sends a hybrid coding visual stimulus to subjects to evoke a specific EEG signal as required; the acquisition module obtains data information by amplifying and filtering the EEG signal so as to constitute EEG signal module; the decoding module coverts the data information into an instruction set for outputting the coding method of the present invention uses asymmetric characteristics of brain electrophysiological activity response to stimulus, combines with coding strategies such as SDMA, CDMA, FDMA and phase division multiple access coding.
    Type: Grant
    Filed: December 30, 2018
    Date of Patent: January 11, 2022
    Inventors: Minpeng Xu, Dong Ming, Xiaolin Xiao
  • Patent number: 11213342
    Abstract: A surgical instrument includes: a handpiece; a movable member configured to transmit a driving force to a treating member to treat a subject by moving relatively to the handpiece; and a connector arranged inside the handpiece, and including a strip to apply a pressing force to the movable member. The movable member includes a first conductive portion formed therein. The connector includes a second conductive portion formed on the strip. The second conductive portion abutting against the first conductive portion to connect the movable member and the handpiece electrically. The second conductive portion of the connector is a molded interconnect device constituting a three-dimensional circuit.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: January 4, 2022
    Inventors: Kenjiro Kanno, Tomoyuki Tsuchiya
  • Patent number: 11194038
    Abstract: A multistatic array topology and image reconstruction process for fast 3D near field microwave imaging are presented. Together, the techniques allow for hardware efficient realization of an electrically large aperture and video-rate image reconstruction. The array topology samples the scene on a regular grid of phase centers, using a tiling of multistatic arrays. Following a multistatic-to-monostatic correction, the sampled data can then be processed with the well-known and highly efficient monostatic Fast Fourier Transform (FFT) imaging algorithm. In this work, the approach is described and validated experimentally with the formation of high quality microwave images. The scheme is more than two orders of magnitude more computationally efficient than the backprojection method. In fact, it is so efficient that a cluster of four commercial off-the-shelf (COTS) graphical processing units (GPUs) can render a 3D image of a human-sized scene in 0.048-0.101 seconds.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: December 7, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: William F. Moulder, James D. Krieger, Denise T. Maurais-Galejs, Huy T. Nguyen, Jeffrey S. Herd
  • Patent number: 11166632
    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: November 9, 2021
    Assignees: Massachusetts Institute of Technology, Elemind Technologies, Inc.
    Inventors: Nir Grossman, David Wang, Edward Boyden
  • Patent number: 11150156
    Abstract: The purpose of the present invention is to propose a device for detecting refrigerant leaks in a refrigeration cycle. The device can be applied irrespective of whether a liquid-receiving tank is present, has a simple configuration, and can be installed easily and inexpensively as a retrofit. Moreover, the device is configured so as to detect the presence of leaks without stopping operation of the equipment, and is innovative and of exceptional utility such that there is no decrease in the equipment operation rate as caused by detection of leaks.
    Type: Grant
    Filed: February 15, 2016
    Date of Patent: October 19, 2021
    Assignee: NANBA CO., LTD.
    Inventors: Shunsuke Nanba, Syoichi Nanba
  • Patent number: 11122978
    Abstract: A dual-modality photoacoustic remote sensing combined with optical coherence tomography (PARS-OCT) system for visualizing details in a sample, the system comprising one or more light sources configured to generate (1) one or more excitation beams configured to generate signals in the sample at one or more first locations below a surface of the sample; (2) one or more interrogation beams incident on the sample at one or more second locations; (3) a sample beam; and (4) a reference beam.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: September 21, 2021
    Inventors: Parsin Haji Reza, Zohreh Hosseinaee, Kevan Bell, Saad Abbasi, Ben Eccelstone
  • Patent number: 11123039
    Abstract: Embodiments provide an ultrasound treatment system and method. In some embodiments, the system includes a removable transducer module having an ultrasound transducer. In some embodiments, the system can include a hand wand with at least one finger activated controller and a control module that is coupled to the hand wand and has a graphical user interface for controlling the removable transducer module, and an interface coupling the hand wand to the control module. The interface may provide power to the hand wand or may transfer a signal from the hand wand to the control module. In some embodiments, the treatment system may be used in cosmetic procedures on at least a portion of a face, head, neck, and/or other part of a patient.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: September 21, 2021
    Assignee: Ulthera, Inc.
    Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
  • Patent number: 11116531
    Abstract: A surgical instrument has a first modular assembly and a second modular assembly. The first modular assembly has a body, an ultrasonic waveguide, an ultrasonic blade connected to a distal end of the ultrasonic waveguide, and a coupling member that movably couples with the body. The second modular assembly has a clamp arm assembly with a first pivot coupling, a clamp pad assembly with a second pivot coupling, and a distal outer sheath that selectively couples to the body of the first modular assembly via the coupling member. The distal outer sheath has an interior surface that houses a portion of the ultrasonic waveguide, and this interior surface also houses the first pivot coupling and the second pivot coupling.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: September 14, 2021
    Assignee: Cilag GmbH International
    Inventors: Ryan M. Asher, Chad P. Boudreaux, Joseph Dennis, Wei Guo, Bryce L. Heitman, James A. McCrea, Patrick J. Minnelli, Yachuan Yu, Monica L. Zeckel, Junhua Zhu
  • Patent number: 11103416
    Abstract: A device for the prevention of stroke is provided that has a processor, a compression system, a compression member, and a vascular probe carried by the compression member. The vascular probe senses a parameter of a circulation system from a closed neck artery that is not being externally accessed. The processor processes the closed parameter and based upon this processing communicates with the compression system to instruct the compression system to actuate the compression member. The compression member and vascular probe are external to the interior of the patient when the vascular probe senses the closed parameter of the circulation system.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: August 31, 2021
    Inventor: Michael Zhadkevich
  • Patent number: 11096752
    Abstract: A robotic surgical system comprising a surgical instrument comprising an end effector comprising (i) a blade, (ii) a first jaw member including a first electrode, and (iii) a second jaw member including a second electrode. The robotic surgical system may also comprise a motor and a control circuit configured to: (i) produce control signals comprising a first control signal and a second control signal, (ii) deliver an electrosurgical energy signal to the first electrode and the second electrode via the first control signal, (iii) deliver a drive signal to the motor via the second control signal (iv) receive at least one feedback signal, (v) determine a rate of change based on a first feedback signal of the at least one feedback signal, and (vi) maintain the rate of change at a predetermined rate or within a predetermined range.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: August 24, 2021
    Assignee: Cilag GmbH International
    Inventors: Foster B. Stulen, Randolph C. Stewart, Chad P. Boudreaux
  • Patent number: 11083380
    Abstract: A bio-signal acquiring apparatus includes a sensor part and a signal processor. The sensor part includes a bio-signal sensor, a load sensor, and an ultrasonic sensor array, the bio-signal sensor configured to detect a bio-signal of an object that comes into contact with the sensor part, the load sensor configured to detect a contact load of the object, and the ultrasonic sensor array configured to detect contact load distribution of the object. The signal processor is configured to obtain a contact load of the object at a region of interest based on the contact load and the contact load distribution, and configured to output the contact load of the object at the region of interest and the bio-signal.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: August 10, 2021
    Inventors: Yong Joo Kwon, Sang Yun Park, Jae Min Kang, Byung Hoon Ko, Jeong Eun Hwang
  • Patent number: 11083619
    Abstract: A flexible device having a layered structure for delivering electrical stimulation and one or both of light and ultrasound to a skin surface is provided. The device is flexible so as to form a non-planar contact surface against the skin surface, and includes one or both of (a) a flexible light emitter layer positioned between two flexible conductive layers that emits light when driven by a power source and (b) a flexible ultrasound emitter layer positioned between two flexible conductive layers that produces ultrasound when driven by a power source. The device also includes a flexible electrical stimulation layer that functions as an electrode and is configured to provide electrical stimulation when driven by a power source.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 10, 2021
    Assignee: CAREWEAR CORP.
    Inventors: Michael R. Hall, John C. Castel, Dawn Castel
  • Patent number: 11058399
    Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: July 13, 2021
    Inventors: Zhen Xu, Ryan M. Miller, Adam D. Maxwell, Charles A. Cain
  • Patent number: 11045143
    Abstract: A multi-lumen catheter with a connectable hub for monitoring intra-abdominal pressure including an expandable outer balloon and a first lumen communicating with the balloon. The balloon and first lumen are filled with gas to form a gas filled chamber to monitor pressure within the bladder to thereby monitor pressure within an abdomen of the patient. A second lumen communicates with the bladder to remove fluid from the bladder. The hub includes a pressure transducer for measuring bladder pressure based on gas compression and has an elongated member insertable into the first lumen to advance gas through first lumen to expand the balloon.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: June 29, 2021
    Assignee: Sentinel Medical Technologies, LLC
    Inventors: Timothy McKinney, Marc-Alan Levine
  • Patent number: 11033292
    Abstract: A medical device is described having a handle, a shaft coupled to the handle, an end effector coupled to the shaft and an ultrasonic transducer coupled to the end effector for delivering ultrasonic energy to tissue or a vessel to be treated. A drive circuit is provided for generating a drive signal that is applied to the ultrasonic transducer. In one embodiment, the drive circuit includes a resonant circuit and a controller that varies the period of the drive signal passed through the resonant circuit in order to control the power supplied to the ultrasonic transducer.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: June 15, 2021
    Assignee: Cilag GmbH International
    Inventors: Alan Edward Green, Paul Christopher Roberts, Mark David Tuckwell, Peter Ralph Bonham
  • Patent number: 11020617
    Abstract: Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: June 1, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Elisa E. Konofagou, Matthew Downs, Stephen Lee, Min Gon Kim, Hermes Arytto Salles Kamimura
  • Patent number: 11013938
    Abstract: Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 25, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Elisa E. Konofagou, Matthew Downs
  • Patent number: 11016186
    Abstract: In a method for detection of defective ultrasonic transducers in an in ultrasonic sensing device, an ultrasonic signal is generated at an ultrasonic sensing device comprising a plurality of ultrasonic transducers. A reflected ultrasonic signal corresponding to the ultrasonic signal is received at at least one ultrasonic transducer of the plurality of ultrasonic transducers. It is determined whether performance the at least one ultrasonic transducer is degraded based at least in part on the reflected ultrasonic signal.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 25, 2021
    Assignee: InvenSense, Inc.
    Inventors: Harihar Narasimha-Iyer, Hao-Yen Tang
  • Patent number: 11006997
    Abstract: A generator is configured to output two or more waveforms at different frequencies. In particular, the generator is configured to provide an ultrasonic waveform, which may be suitable for driving a transducer of an ultrasonic surgical instrument, and electrosurgical radiofrequency energy, which may be suitable for electrosurgical instruments.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: May 18, 2021
    Assignee: Covidien LP
    Inventors: Steven C. Rupp, Robert B. Smith, Daniel A. Friedrichs
  • Patent number: 10993694
    Abstract: The present invention generally relates to devices for imaging the interior of a vessel. The device can involve an elongated body configured to fit within the lumen of a vessel, a rotatable shaft positioned inside the elongated body, and a telescoping element, wherein a portion of the elongated body extends through the telescoping element, in which the elongated body is configured to contain the rotatable shaft inside the telescoping element.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: May 4, 2021
    Inventors: Douglas Meyer, Dylan Van Hoven
  • Patent number: 10981021
    Abstract: The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: April 20, 2021
    Assignees: Carthera, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie (Paris 6)
    Inventors: Alexandre Carpentier, Michael Canney, Alexandre Vignot
  • Patent number: 10974078
    Abstract: Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: April 13, 2021
    Inventors: Shelly Jordan, Mark Evan Schafer, Alex Korb, Walter William Wurster
  • Patent number: 10970395
    Abstract: An exemplary security threat monitoring system receives performance metric data representative of a performance metric for a storage system, applies the performance metric data as an input to an unsupervised machine learning model, and identifies, based on an output of the unsupervised machine learning model, an anomaly in the performance metric data.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: April 6, 2021
    Assignee: Pure Storage, Inc
    Inventors: Apoorva Bansal, Olivia Watkins, Jonathan Hayase, Nikita Bhargava, Christopher Golden, Sergey Zhuravlev
  • Patent number: 10959768
    Abstract: Systems and methods for facilitating treatment are disclosed that can include the use of imaging techniques in conjunction with one or more non-invasive techniques for modifying tissue, e.g., tissue in or around the spine. Depending on the type of treatment to be performed, various imaging modalities may be suitable for visualizing the tissue. Energy can be applied to tissue from outside of the body such that the tissue is modified in a non-invasive manner. For example, focused ultrasound can be used to dissect body tissues or can be applied to specific regions of tissue to change a characteristic of the tissue, e.g., increase its elasticity. The methods disclosed herein can be stand-alone treatments or can be performed prior to one or more surgical procedures. For example, non-invasive imaging and modification of body tissues can facilitate accessing the spine, preparing an interbody space, and/or surgically correcting the spine.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: March 30, 2021
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Michael Slivka, Kevin Lee, Roman Lomeli
  • Patent number: 10960234
    Abstract: A method of treating a condition associate with accumulation of an agent in cells in a patient includes exposing the cells to ultrasound, to selectively kill or induce apoptosis in the cells. The cells include the accumulated agent.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: March 30, 2021
    Assignee: Siwa Corporation
    Inventor: Lewis S. Gruber
  • Patent number: 10952759
    Abstract: Various ultrasonic instruments are disclosed. The ultrasonic instruments include structures configured to indicate the cutting length of the instruments, detect when grasped tissue has extended beyond the cutting length of the instrument, and prevent tissue from extending beyond the cutting length. Several techniques for each types of structures are disclosed.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: March 23, 2021
    Assignee: Ethicon LLC
    Inventors: Jeffrey D. Messerly, William E. Clem, John A. Weed, III, Eric Stout, Craig T. Davis, John E. Brady, Joseph D. Dennis, Phillip H. Clauda, Monica L. Z. Rivard
  • Patent number: 10940335
    Abstract: An ultrasound stimulation helmet (100) configured to regulate an endogenous neurotrophic factor in a brain or expression of proteins related to a neurodegenerative disease comprises: a main body (1) having a forehead perimeter adjustment knob (12), a back head perimeter adjustment knob (13), a fastening support frame (14), and multiple position adjustment knobs (15); and multiple ultrasound probes (2) detachably mounted on the main body (1), wherein the ultrasound probe (2) has a frequency adjustment button and an intensity adjustment button to respectively control an output frequency and output intensity of the ultrasound probe (2), and other ultrasound parameters and an angle of the ultrasound probe (2) itself are adjustable as well.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: March 9, 2021
    Assignee: National Yang-Ming University
    Inventor: Feng-Yi Yang
  • Patent number: 10932845
    Abstract: An apparatus includes a body, a shaft assembly, an articulation section, an end effector, and an articulation drive assembly. The articulation drive assembly is configured to drive the articulation section to deflect the end effector relative to the longitudinal axis from a non-articulated configuration to an articulated configuration. The articulation drive assembly includes a rotatable housing, a static member, and an indication feature. The rotatable housing is rotatably coupled to the body. The static member is fixed relative to the body. The indication feature is configured to indicate when the end effector is deflected into the non-articulated configuration. The indication feature includes a ridge and a cantilever arm. The ridge extends from an exterior surface of the rotatable housing. The cantilever arm defines a slot configured to house the ridge when the end effector is in the non-articulated configuration.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: March 2, 2021
    Assignee: Ethicon LLC
    Inventor: Barry C. Worrell
  • Patent number: 10925666
    Abstract: A catheter for use with a suction source for removing excess fluid from a tissue treatment site has a catheter body, a distal section and a fluid evacuation path, where the distal section includes a multi-lumened member and at least one evacuation port, and the fluid evacuation path extends through a lumen in the multi-lumened member to provide suction communication between the suction source and the at least one evacuation port. The fluid evacuation path may also be configured for two-way flow, including distally and proximally along the catheter.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: February 23, 2021
    Inventors: Rogelio Plascencia, Jr., Dean Ponzi, Arnold Tuason
  • Patent number: 10918304
    Abstract: A rheology system (202) includes a rheology transducer device (204) for introducing mechanical waves into a subject of interest (120). The rheology transducer device (204) includes multiple transducers (212), a driving device (206) for driving the rheology transducer device (204), a sensor device (208) for sensing mechanical waves at the subject of interest (120), and a control device (210) for receiving input from the sensor device (208) and for controlling the driving device (206) based on the received input from the sensor device (208). An MR rheology system (200) includes the above rheology system (202) and an MR imaging system (110) adapted to control the rheology system (200). A rheology method includes with the rheology system (202), driving the rheology transducer device (204) to introduce mechanical waves into the subject of interest (120), sensing mechanical waves at the subject of interest (120), and performing feedback control.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: February 16, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Daniel Wirtz, Christoph Leussler, Peter Mazurkewitz
  • Patent number: 10898711
    Abstract: Described is system for mapping user behavior to brain regions of interest. Using a cognitive-behavior model, a behavioral task is selected that is suited for a desired brain state. Using a functional-anatomical model coupled to the cognitive-behavior model, a set of high-definition neurostimulations is selected to be applied to the user during performance of the selected behavioral task. The selected set of high-definition neurostimulations targets specific regions of the user's brain. Changes in the user's brain state are sensed during application of the set of high-definition neurostimulations and performance of the selected behavioral task using at least one brain monitoring technique. The coupled functional-anatomical and cognitive-behavior models are adapted until the desired brain state is reached.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: January 26, 2021
    Assignee: HRL Laboratories, LLC
    Inventors: Matthew E. Phillips, Matthias Ziegler, David W. Payton, Charles E. Martin
  • Patent number: 10881882
    Abstract: The presented methods and devices may provide at least one treatment action leading to one or more treatment effects including influencing the tissue to enhance, renew or improve biosynthesis of at least one component of an extracellular matrix. In one embodiment, the methods and devices may provide treatment effects to skin fibroblasts and/or fasciacytes of the patient, influencing the skin fibroblasts and/or fasciacytes to enhance, renew or improve biosynthesis of hyaluronic acid.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: January 5, 2021
    Inventors: Tomá{hacek over (s)} Schwarz, Daniel Mali{hacek over (s)}