Ultrasonic Patents (Class 601/2)
  • Patent number: 12097382
    Abstract: A method for covertly creating adverse health effects in a human subject includes generating at least one electromagnetic wave at a frequency within the range of about 300 MHz (megahertz) and about 300 GHz (gigahertz). The at least one electromagnetic energy wave is pulsed at a pulse frequency within a target range of human neural oscillations. The at least one pulsed electromagnetic wave is remotely transmitted to the subject's brain.
    Type: Grant
    Filed: September 25, 2023
    Date of Patent: September 24, 2024
    Inventors: Elwood Norris, Seth Putterman
  • Patent number: 12096991
    Abstract: The invention relates to a position determining device for determining a position of an elongate object within a tubular structure, said position determining device comprising a first providing unit for providing a first distribution of curvature values at a plurality of first points along a path within the tubular structure. The position determining device further comprises a second providing unit for providing a second distribution of strain values or of curvature values at a plurality of points along the object, and a position determining unit for determining the position of the object relative to the path on the basis of the first and second distributions.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: September 24, 2024
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
    Inventors: Jan Strehlow, Torben Pätz, Horst Hahn
  • Patent number: 12082789
    Abstract: A method for minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising: guiding a laser fiber within a patient with a guidance tool; measuring a temperature within the target tissue and the safety zone based on an invasive and a non-invasive thermal sensor; computing a thermal profile in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient; and controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: September 10, 2024
    Assignee: Convergent Life Sciences, Inc.
    Inventors: Dinesh Kumar, Amit Vohra, Daniel S. Sperling
  • Patent number: 12070235
    Abstract: A device and method for perforating a dense bone layer. The device includes a vibration generator for generating mechanical vibration, in particular ultrasonic vibration, and an instrument with an elongated shaft and a distal end piece including a perforator. The distal end piece is arranged at a distal end of the shaft and the proximal end of the shaft is connected or connectable to the vibration generator. The perforator has the form of a solid or a hollow cylinder. The vibration generator, the shaft and the distal end piece are adapted to each other for the shaft to transmit, when connected to the activated vibration generator, mechanical vibration from the vibration generator to the distal end piece and for vibrating the perforator in a direction parallel to its cylinder axis.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 27, 2024
    Assignee: BOSONIC AG
    Inventors: Andrè Schwery, Jörg Mayer
  • Patent number: 12064389
    Abstract: A method for treating a kidney with focused extracorporeal shockwaves in a noninvasive manner. The method configured for the treatment of chronic kidney disease (CKD) at any one of CKD stage 1 to CKD stage 4. The method of treatment comprising using non-invasive extracorporeal shockwaves having an energy density of 0.02 to 0.18 mJ/mm2 that are delivered to at least one treatment zone selected from various focal zones encompassing renal structures.
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: August 20, 2024
    Inventor: Avner Spector
  • Patent number: 12064287
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Grant
    Filed: September 6, 2022
    Date of Patent: August 20, 2024
    Assignee: Sunnybrook Research Institute
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Patent number: 12067161
    Abstract: Ultrasonic transducers may be used to track the position of an object. For example, eyewear such as a pair of glasses or other head-mounted device may use ultrasonic transducers to track a user's eye position and gaze direction. To increase positioning accuracy over short-range distances, an array of ultrasonic transducers with different center frequencies may be formed on a common substrate. The closely spaced ultrasonic transducers with relatively small individual bandwidths may be used to simulate a single transducer with a larger bandwidth. Control circuitry may adjust the phases of the transducers in the array to steer the ultrasonic signal beam towards the user's eye and/or to receive an ultrasonic signal beam from the direction of the user's eye. The control circuitry may use time delay and/or phase delay measurement techniques to determine a distance and/or direction to the user's eye using the ultrasonic transducer arrays.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: August 20, 2024
    Assignee: Apple Inc.
    Inventors: Ehsan Arbabi, Patrick R. Gill, Avery L. Wang
  • Patent number: 12054788
    Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: August 6, 2024
    Assignee: Washington University
    Inventors: Eric Claude Leuthardt, Gavin P. Dunn, Hong Chen, Allegra Petti
  • Patent number: 12053652
    Abstract: An ultrasound therapy device for generating ultrasound therapy. The ultrasound therapy device includes a wearable structure, ultrasound transducer units, a tightening mechanism, a memory, and a processor. The wearable structure is securable to a user to transmit the ultrasound to a target therapy area of a user including at least one of a kidney region, a lung region, and a lower limb of the user. The ultrasound transducer units are attachable and repositionable in the wearable structure to generate and deliver the ultrasound to the target region. The ultrasound transducer units are arranged in an array. The array of ultrasound transducer units is mechanically moved within the wearable structure and is in contact with a material to facilitate penetration of ultrasound into the user's body.
    Type: Grant
    Filed: January 16, 2023
    Date of Patent: August 6, 2024
    Assignee: CSW Therapeutics AB
    Inventors: Filip Ludwig Peters, Christopher Lee Stokely, Mena Nadum
  • Patent number: 12029311
    Abstract: A device for providing oral care includes at least one lumen fluidly coupled to a brush head. The lumen is adapted to suction fluid via an aperture disposed within the brush head. The brush head may be provided an oral cleaning fluid to facilitate cleaning of oral anatomy. The oral cleaning fluid may be provided within a cup provided within a containment assembly coupled to the oral care tool. Alternatively, or in addition, the cleaning fluid may be provided via fluid reservoir fluidly coupled to the oral care tool. The brush head comprises a bristles section and a foam section.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: July 9, 2024
    Assignee: Sage Products, LLC
    Inventors: Brett C. Blabas, Ronald C. Cagle, Thomas Keaty, Jr., Jay Roberts, David P. Beck, Heather K. Mercier
  • Patent number: 11998501
    Abstract: Systems for promoting sexual well-being in males and for treating erectile dysfunction using acoustic energy.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: June 4, 2024
    Assignee: Kemeny Healthcare Inc.
    Inventors: Csaba Truckai, John H. Shadduck, Akos Toth
  • Patent number: 11992365
    Abstract: Various embodiments are generally directed to a flexible elongate member (e.g., endoscopic accessory tool) positionable into and/or through selected anatomies, such as by generating images to position components of a flexible elongate member or to localize anatomic features, for instance. Some embodiments are directed to generating images with a plurality of imaging techniques to localize anatomic features and/or components of a flexible elongate member for one or more of inspection, orientation, and/or facilitating access to body passageways or lumens.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: May 28, 2024
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Peter L. Dayton, Barry Weitzner, Megan Chrobak, Thomas Jones, Mark W. Boden, James Weldon, Elizabeth M. Albrecht, George Wilfred Duval
  • Patent number: 11980778
    Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.
    Type: Grant
    Filed: May 2, 2023
    Date of Patent: May 14, 2024
    Assignee: HistoSonics, Inc.
    Inventors: Jonathan M. Cannata, Ryan M. Miller, Alexander P. Duryea, Dejan Teofilovic, Zeljko Mladenovic, Aleksandra Rakic, Joshua Stopek
  • Patent number: 11969609
    Abstract: Embodiments of a dermatological cosmetic treatment and imaging system and method can include use of transducer to simultaneously or substantially simultaneously produce multiple cosmetic treatment zones in tissue. The system can include a hand wand, a removable transducer module, a control module, and/or graphical user interface. In some embodiments, the cosmetic treatment system may be used in cosmetic procedures, including brow lifts, fat reduction, sweat reduction, and treatment of the décolletage. Skin tightening, lifting and amelioration of wrinkles and stretch marks are provided.
    Type: Grant
    Filed: December 5, 2022
    Date of Patent: April 30, 2024
    Assignee: Ulthera, Inc.
    Inventor: Charles D. Emery
  • Patent number: 11944847
    Abstract: A method for delivering ultrasound therapy using open-loop controls comprises inserting a distal tip of a therapeutic ultrasound applicator into a patient's urethra, the distal tip including an ultrasound transducer; acquiring ultrasound images of the patient's urethra and prostate with an ultrasound imaging probe; aligning the distal tip of the therapeutic ultrasound applicator with the patient's prostate using the ultrasound images; delivering therapeutic ultrasound energy to the patient's prostate, with the ultrasound transducer, according to a treatment plan, the treatment plan including a predetermined limited angular range for the therapeutic ultrasound energy that avoids the patient's rectum and neurovascular bundles, wherein the therapeutic ultrasound is delivered without temperature feedback data.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: April 2, 2024
    Assignee: Profound Medical Inc.
    Inventor: Mathieu Allard
  • Patent number: 11944494
    Abstract: According to the present invention, a transducer part is mechanically scanned in a chamber for a medium. A pair of diaphragms are provided to the two sides of the transducer part (one side and the other side in the mechanical scanning direction). Each of the diaphragms has a hollow membrane and a base. The hollow membrane has a pair of longitudinal lateral surfaces extending in a longitudinal direction parallel to the center axis of rotation. An attachment hole is formed in a partition wall, and a projecting part provided on the base is inserted into the attachment hole.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: April 2, 2024
    Assignee: FUJIFILM HEALTHCARE CORPORATION
    Inventor: Tomoo Takahashi
  • Patent number: 11938277
    Abstract: A catheterization system including a catheter, drainage bag and one or more indicators configured to measure an attribute relating to the usage of the catheter system and communicate information about the attribute to a network, such as an EMR database. The indicators may include a location indicator, a duration indicator, an elevation indicator, a tamper indicator, a dependent loop indicator, a floor contact indicator, and a patient securement indicator. The system may autonomously detect and record one or more attributes relating to the usage of the catheter system.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: March 26, 2024
    Assignee: C. R. Bard, Inc.
    Inventors: Tim Waitkus, Chris Fodouop, Kelsey Leeke, John Gohde, Logan Madden, Nichole Abla
  • Patent number: 11936415
    Abstract: An air interface plane (AIP) of a radio frequency (RF) aperture includes: a circuit board having a first side and a second side opposite the first side; and a matrix of tapered elements arranged on the first side of the circuit board and secured to the circuit board, the matrix of tapered elements cooperating to at least one of receive or transmit an over-the-air RF signal. Suitably, each tapered element of the matrix has: a central hub extending along a longitudinal axis from a hub base which is proximate to the first side of the circuit board to an apex of the tapered element which is distal from the first side of the first circuit board; and a plurality of arms extending from the central hub at the apex of the tapered element, each of the plurality of arms including a first portion that projects the arm radially away from the longitudinal axis and a second portion that projects the arm longitudinally toward the first side of the circuit board.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: March 19, 2024
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Raphael Joseph Welsh, Douglas A. Thornton, Mackenzie Jordan Hawkins, Micah John Meleski, Katherine M. Armitage, Daniel G. Loesch, Matthew E. Huntwork, David R. Chase, Erik W. Edwards, John Bartholomew, Thomas Lloyd Moffitt, Curt Hudberg
  • Patent number: 11931202
    Abstract: An ultrasound automatic scanning system according to an embodiment includes an ultrasound probe, a mechanical mechanism, and processing circuitry. The ultrasound probe transmits and receives ultrasonic wave. The mechanical mechanism holds and moves the ultrasound probe while an ultrasonic-wave transmission-reception surface of the ultrasound probe is pointed to a subject. The processing circuitry acquires a distance between a body surface of the subject and the ultrasonic-wave transmission-reception surface of the ultrasound probe based on reflected wave data collected while the ultrasound probe is moved by the mechanical mechanism. The processing circuitry generates, based on information of the distance, locus information of movement of the ultrasound probe when ultrasound scanning is executed on the subject. The mechanical mechanism executes ultrasound scanning on the subject by moving the ultrasound probe based on the locus information generated by the processing circuitry.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: March 19, 2024
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Yusuke Kobayashi, Satoshi Matsunaga
  • Patent number: 11918485
    Abstract: Piezoelectric osteotomy devices and corresponding systems and methods for removing an acetabular cup or shell from a patient's acetabulum are disclosed. In one embodiment, the piezoelectric osteotomy device includes a piezoelectric element to actuate a cutting tip on an armature. In some such embodiments, the cutting tip may be extended and/or retracted to facilitate cutting of bone around an acetabular cup. The armature may include a fluid output port located proximate the cutting tip to mitigate heat generated by the cutting tip. In one embodiment, the piezoelectric osteotomy device is arranged and configured to provide constant current adjustment.
    Type: Grant
    Filed: December 12, 2022
    Date of Patent: March 5, 2024
    Assignees: SMITH & NEPHEW, INC., SMITH & NEPHEW ORTHOPAEDICS AG, SMITH & NEPHEW ASIA PACIFIC PTE. LIMITED
    Inventors: Michael Bozeman, Monali Shah, Roy Messina, Andrea Karduss, Jeffrey J. Shea
  • Patent number: 11918996
    Abstract: Integrated cartridges for sample homogenization, nucleic acid fragmentation, and nucleic acid detection are disclosed herein. The integrated cartridges include a main housing having a sample well and a detection chamber and a sonication feature coupled to and extending outwardly from the main housing. The sonication feature includes a sonication chamber for receiving a sample fluid. A fluidic path directs the sample fluid from the sample well, to the sonication chamber, and to the detection chamber. Systems for use with the integrated cartridges can include sonotrodes with openings for positioning the sonication feature and/or temperature sensors for monitoring the temperature of the sonication feature. Methods include moving the sample fluid from the sample well to the sonication feature, transmitting ultrasonic energy into the sample fluid, moving the sample fluid from the sonication feature to the detection chamber, and performing a nucleic acid detection assay within the detection chamber.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: March 5, 2024
    Assignee: GeneCapture, Inc.
    Inventors: Greg Thompson, Zachary McGee, Paula Millirons
  • Patent number: 11921473
    Abstract: Apparatus, systems, articles of manufacture, and methods to generate acceptability criteria for autonomous systems plans are disclosed. An example apparatus includes a data compiler to compile data generated by the autonomous system into an autonomous system task dataset, a data encoder to encode the dataset for input into a rule distillation neural network architecture, a model trainer to train the rule distillation neural network architecture, an adaptor to adapt the trained rule distillation neural network architecture to a new input data domain using the autonomous system task dataset, a verifier to generate formally verified acceptability criteria, and an inferer to evaluate a control command, the evaluation resulting in an acceptance or rejection of the command.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 5, 2024
    Assignee: INTEL CORPORATION
    Inventors: Javier Felip Leon, Javier Sebastian Turek, David I. Gonzalez Aguirre, Ignacio Javier Alvarez, Luis Carlos Maria Remis, Justin Gottschlich
  • Patent number: 11918832
    Abstract: Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: March 5, 2024
    Assignee: Insightec Ltd.
    Inventors: Yoav Levy, Eyal Zadicario, Javier Grinfeld, Rafi De Picciotto
  • Patent number: 11903118
    Abstract: An assembly including: a printed circuit board (PCB) having a first surface and a second surface; at least one energy transmitter mounted on the first surface; at least one cooling element associated with the PCB second surface, wherein the cooling element is configured to cool the at least one energy transmitter via the PCB.
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: February 13, 2024
    Assignee: Sofwave Medical Ltd.
    Inventors: Ariel Sverdlik, Erez Panir
  • Patent number: 11901930
    Abstract: An air interface plane (AIP) of a radio frequency (RF) aperture includes: a circuit board having a first side and a second side opposite the first side; and a matrix of tapered elements arranged on the first side of the circuit board and secured to the circuit board, the matrix of tapered elements cooperating to at least one of receive or transmit an over-the-air RF signal. Suitably, each tapered element of the matrix has: a central hub extending along a longitudinal axis from a hub base which is proximate to the first side of the circuit board to an apex of the tapered element which is distal from the first side of the first circuit board; and a plurality of arms extending from the central hub at the apex of the tapered element, each of the plurality of arms including a first portion that projects the arm radially away from the longitudinal axis and a second portion that projects the arm longitudinally toward the first side of the circuit board.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: February 13, 2024
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: David R. Chase, Micah Blue, Michael Jansen, Curt Hudberg
  • Patent number: 11890060
    Abstract: Disclosed is a system to assist in a procedure. During the procedure an object may be moved relative to a subject, such as being positioned and/or placed within a subject. The system and related method may be used to assist in displaying and/or determining a pose of the object relative to a subject, such as rigid portions of a subject.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: February 6, 2024
    Assignee: Medtronic Navigation, Inc.
    Inventors: Matthew W. Koenig, Marco Capote
  • Patent number: 11864951
    Abstract: The invention relates to a probe (110, 210, 310, 410, 510) which has a sealed cooling chamber (140, 240, 340, 440, 540) arranged within a casing (112, 212, 312, 412, 512) of the probe. An interface unit (124, 224, 324, 424, 524) of the probe is at least partially arranged within the cooling chamber or in contact with the cooling chamber. The cooling chamber is at least partially filled with a heat transfer liquid (142, 242, 342, 442, 542).
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: January 9, 2024
    Assignee: SuperSonic Imagine
    Inventors: Matthieu Valentin, Etienne Rousseau, Frédéric Giral
  • Patent number: 11869208
    Abstract: The present disclosure relates to methods, apparatuses, and computer programs for processing computed tomography images. Precise segmentation of the left atrium (LA) in computed tomography (CT) images constitutes a crucial preparatory step for catheter ablation in atrial fibrillation (AF). We aim to apply deep convolutional neural networks (DCNNs) to automate the LA detection/segmentation procedure and create a three-dimensional (3D) geometries. The deep learning provides an efficient and accurate way for automatic contouring and LA volume calculation based on the construction of the 3D LA geometry. Non-pulmonary vein (NPV) trigger has been reported as an important predictor of recurrence post atrial fibrillation (AF) ablation. Elimination of NPV triggers can reduce the post-ablation AF recurrence. The deep learning was applied in pre-ablation pulmonary vein computed tomography (PVCT) geometric slices to create a prediction model for NPV triggers in patients with paroxysmal atrial fibrillation (PAF).
    Type: Grant
    Filed: March 15, 2021
    Date of Patent: January 9, 2024
    Assignees: TAIPEI VETERANS GENERAL HOSPITAL, National Yang Ming Chiao Tung University
    Inventors: Horng-Shing Lu, Chih-Min Liu, Shih-Lin Chang, Shih-Ann Chen, Yenn-Jiang Lin, Hung-Hsun Chen, Wei-Shiang Chen
  • Patent number: 11865068
    Abstract: A negative pressure massage device which includes a massage stick, an external negative pressure device and a communication pipe. The massage stick includes a stick body, an air channel in the stick body, a negative pressure connection hole and an air suction opening formed at both ends of the stick body and communicated with the air channel. The external negative pressure device is installed separately from the massage stick and includes a housing and a negative pressure drive/control module. The negative pressure drive/control module includes a controller, a negative pressure generating component, a pressure relief assembly and an air pipe assembly with a negative pressure communication hole formed on the housing. The ends of the communication pipe are communicated with the negative pressure connection hole and the negative pressure communication hole. This disclosure provides various negative pressure massage effects and improves the ease of operation.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: January 9, 2024
    Assignees: BIBOTING INT'L. CO., LTD.
    Inventors: Po-Chang Liu, Li-Pin Yuan
  • Patent number: 11850096
    Abstract: A method, device and system for ultrasonic delivery and attachment of ligand-receptor based drugs and/or drug carriers and/or image enhancing contrast agents utilizing catch and slip bond mechanisms in a targeted part(s) of the human or animal (patient) body or organs or tissue is described and disclosed. The system includes an acoustic power source coupled to an acoustic transducer with the acoustic transducer placed upon a patient's delivery zone. The acoustic transducer transmits an acoustic field to the target drug delivery and/or imaging zone. A detection probe and/or a probe of an imaging system are placed over or within said delivery zone and the probe is coupled to a sensing/imaging system. A control computer that controls power and wave shape of the acoustic signal generated into the acoustic filed by the acoustic power source and receives data from the sensing/imaging system.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: December 26, 2023
    Inventor: Cetin Cetinkaya
  • Patent number: 11844562
    Abstract: An electrosurgical forceps includes a first shaft member including a first inner frame. A first jaw member extends distally from the first inner frame. A first outer housing is supported by the first inner frame. The first inner frame includes a first member stamped from sheet metal. A second shaft member includes a second inner frame. A second jaw member extends distally from the second inner frame. A second outer housing is supported by the second inner frame. The second inner frame includes a second member stamped from sheet metal and a rigid filler member disposed on the second member.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: December 19, 2023
    Assignee: Covidien LP
    Inventors: Kelley Goodman, Grant T. Sims, Daniel W. Mercier, Craig Krastins, Jennifer Rich
  • Patent number: 11819685
    Abstract: A method is provided including disposing midplane treatment electrodes over a superior sagittal sinus, outside and in electrical contact with a skull of a head of a subject identified as at risk of or suffering from Alzheimer's disease. Lateral treatment electrodes are disposed between 1 and 12 cm of a sagittal midplane of the skull. The subject is treated by clearing amyloid beta, by activating control circuitry to apply one or more treatment currents between (a) one or more of the midplane treatment electrodes and (b) one or more of the lateral treatment electrodes; and configure the midplane treatment electrodes as cathodes, and the lateral treatment electrodes as anodes. Other embodiments are also described.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: November 21, 2023
    Assignee: RAINBOW MEDICAL LTD.
    Inventor: Yossi Gross
  • Patent number: 11801400
    Abstract: A therapy apparatus for treating tissue by emission of focused ultrasound waves, including: a creation surface of a pressure field of focused ultrasound waves divided into at least N sectors having segments of asymmetrical concave curve with centres of curvature; centres of curvature asymmetrical to the extent where the centres of curvature are situated at different distances from the plane of symmetry or from at least one of the axis of symmetry and at different depths taken according to the axis of symmetry; the individual axes intersecting between the focal zones and the creation surface or beyond the focal zones such that the beams originating from the sectors intersect to create a focal coverage zone which is off-axis relative to the plane of symmetry or to the axis of symmetry; the sectors of this creation surface creating energy deposit zones with profiles corresponding to the focal coverage zones.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: October 31, 2023
    Assignees: EDAP TMS FRANCE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDECALE (INSERM), UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE LEON BERARD
    Inventors: Marine Sanchez, David Melo De Lima, Jérémy Vincenot
  • Patent number: 11801394
    Abstract: A method for covertly creating adverse health effects in a human subject includes generating at least one electromagnetic wave at a frequency within the range of about 300 MHz (megahertz) and about 300 GHz (gigahertz). The at least one electromagnetic energy wave is pulsed at a pulse frequency within a target range of human neural oscillations. At least one ultrasonic audio wave is generated at a frequency greater than about 20 kHz (kilohertz). The at least one audio wave is pulsed at the pulse frequency. Each of the at least one pulsed electromagnetic wave and the at least one ultrasonic audio wave are remotely transmitted to the subject's brain.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: October 31, 2023
    Inventors: Elwood Norris, Seth Putterman
  • Patent number: 11804679
    Abstract: An energy module is disclosed. The energy module includes a hand-switch circuit, a surgical instrument interface coupled to the hand-switch circuit, and a control circuit coupled to the surgical instrument interface and the hand-switch circuit. The control circuit is configured to control the hand-switch circuit to communicate with a surgical instrument coupled to the hand-switch circuit using a plurality of communication protocols over a single wire. The control circuit is configured to control the hand-switch circuit to supply power to the instrument over the single wire.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: October 31, 2023
    Assignee: Cilag GmbH International
    Inventors: Joshua Henderson, Joshua P. Morgan, Andrew W. Carroll, Jeffrey L. Aldridge, Eitan T. Wiener, James M. Vachon
  • Patent number: 11794040
    Abstract: Apparatuses and methods for generating therapeutic shock waves. Some embodiments comprise: an acoustic-wave generator configured to emit acoustic waves having at least one frequency between 1 MHz and 1000 MHz; a shock wave housing coupled to the acoustic-wave generator; and a shock wave medium disposed in the shock wave housing; where the apparatus is configured such that if the acoustic-wave generator emits acoustic waves then at least some portion of the acoustic waves will travel through the shock wave medium and form one or more shock waves.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: October 24, 2023
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Christopher C. Capelli
  • Patent number: 11786760
    Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: October 17, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: John Frederick Graf, Christopher Michael Puleo, Jeffrey Michael Ashe, Victoria Eugenia Cotero, David Andrew Shoudy
  • Patent number: 11771447
    Abstract: A method of treatment of the human or animal body with noninvasive low energy extracorporeal shockwaves and in particular, to such a method that is utilized for controlling a cascade of biomolecular activity involving a plurality of biomolecular factors, provided to improve function of the treatment portion of the human or animal body.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: October 3, 2023
    Inventors: Avner Spector, Tamar Shultz More
  • Patent number: 11766576
    Abstract: Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Brainsonix Corporation
    Inventors: Shelly Jordan, Mark Evan Schafer, Alex Korb, Walter William Wurster
  • Patent number: 11766382
    Abstract: An example skincare device includes a main body having a first side, a second side, an intermediate portion, a groove, a light source, a motor, a temperature control unit, and a user control configured to control one or more of the light source, motor, and temperature control unit. The skincare device can provide heat, cool, light, and/or vibrational therapy to a user's skin.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: September 26, 2023
    Assignee: FOREO Inc.
    Inventor: Filip Sedic
  • Patent number: 11738215
    Abstract: A flue for use with an ultrasonic surgical tip, comprising protrusions or bumps on its inner surface with improved protrusion pattern, density and location. The flue has enhanced cooling effect for the ultrasonic surgical tip.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: August 29, 2023
    Assignee: Integra LifeSciences Enterprises, LLP
    Inventors: Daniel J. Cotter, Saurav V. Gupta, Igor V. Kosenko, John Bertorelli, Prakash Manandhar
  • Patent number: 11737736
    Abstract: An ultrasound imaging device or probe includes a tip having a heat conducting exterior housing within which an imaging element is positioned. The imaging element is engaged with a heat sink formed of an electrically insulating material that also has high thermal conductivity. The heat sink contacts and extends through and electrically insulating enclosure within which the imaging element is disposed. As a result, the heat generated by the imaging element can be readily conducted to the ambient environment via the heat sink and heat conductive exterior housing while also enabling the imaging element and other electrical components to be electrically insulated from the housing.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: August 29, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: Birger Løype, Warren Lee, Stephen D. Edwardsen
  • Patent number: 11730446
    Abstract: A catheter-based ultrasound imaging system configured to provide a full circumferential 360-degree view around an intra-vascular/intra-cardiac imaging-catheter-head by generating a three-dimensional view of the tissue surrounding the imaging-head over time. The ultrasound imaging system can also provide tissue-state mapping capability. The evaluation of the vasculature and tissue characteristics include path and depth of lesions during cardiac-interventions such as ablation. The ultrasound imaging system comprises a catheter with a static or rotating sensor array tip supporting continuous circumferential rotation around its axis, connected to an ultrasound module and respective processing machinery allowing ultrafast imaging and a rotary motor that translates radial movements around a longitudinal catheter axis through a rotary torque transmitting part to rotate the sensor array-tip.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: August 22, 2023
    Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
    Inventors: Christoph Hennersperger, Andrew Bourke, Fionn Lahart
  • Patent number: 11724133
    Abstract: Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: August 15, 2023
    Assignee: Guided Therapy Systems, LLC
    Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
  • Patent number: 11724119
    Abstract: The present invention is directed to a method for treating a bowel disease in a subject in need thereof, the method comprising inhibiting the activity of neurons of the insular cortex of the subject. Further provided is a system comprising a transcranial stimulation transducing coil for transcranial stimulation configured to provide a series of pulses to neurons of the insular cortex.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: August 15, 2023
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Asya Rolls, Tamar Koren, Hilla Azulay-Debby, Tamar Ben Shaanan
  • Patent number: 11707635
    Abstract: Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: July 25, 2023
    Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
    Inventors: Hairong Zheng, Hui Zhou, Lili Niu, Ruibiao Guo, Long Meng, Yongchuan Li, Min Su, Jiqing Huang, Ming Qian
  • Patent number: 11684340
    Abstract: An ultrasound endoscope includes: an insertion portion; an ultrasound functional unit including an ultrasound transducer; an endoscope functional unit that at least includes an imaging optical system; and a balloon locking portion configured to connect the ultrasound functional unit and the endoscope functional unit, the balloon locking portion having a groove shape that can lock a balloon. A first plane passes, in a direction of a longitudinal axis of the insertion portion, through a first end portion of the ultrasound transducer near the endoscope functional unit, the first plane being perpendicular to the longitudinal axis of the insertion portion, and the first plane is positioned closer to a proximal end than a second plane passing through a second end portion of the balloon locking portion near the ultrasound functional unit, the second plane being perpendicular to the longitudinal axis of the insertion portion.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: June 27, 2023
    Assignee: OLYMPUS CORPORATION
    Inventor: Toshihiro Kitahara
  • Patent number: 11684387
    Abstract: A method for sealing a vessel includes supplying electrical energy to an ultrasonic surgical instrument having an end effector and a transducer coupled to the end effector, when the end effector is grasping a vessel, sensing parameters of the vessel when the end effector achieves a predetermined velocity, estimating a size of the vessel based on the sensed parameters, controlling the electrical energy based on maintaining a predetermined initial heating rate of heating the vessel until a predetermined amount of energy corresponding to the estimated size of the vessel has been delivered, and controlling the electrical energy based on a predetermined heating rate curve of heating the vessel after the predetermined amount of energy corresponding to the estimated size of the vessel has been delivered.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: June 27, 2023
    Assignee: Covidien LP
    Inventors: David J. Van Tol, Kelly E. Goodman, Keith W. Malang, Christopher T. Tschudy
  • Patent number: 11672553
    Abstract: An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: June 13, 2023
    Assignee: EKOS Corporation
    Inventors: Robert L. Wilcox, Ronald L. Haas
  • Patent number: 11667975
    Abstract: Among the various aspects of the present disclosure is the provision of a noninvasive and localized brain liquid biopsy using focused ultrasound. Briefly, therefore, the present disclosure is directed to methods and systems to identify brain lesion or tumor characteristics without the need for a solid brain biopsy.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: June 6, 2023
    Assignee: Washington University
    Inventors: Eric Leuthardt, Gavin Dunn, Hong Chen, Allegra Petti