Hyperthermia Patents (Class 601/3)
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Patent number: 12357847Abstract: The present invention relates to an ultrasonic wave generating cartridge which comprises: a cartridge housing; an ultrasonic wave generating unit which is disposed so as to be able to move in a reciprocating manner in the cartridge housing; and a position detection unit which can detect the real-time position of the ultrasonic wave generating unit by sending a transmission signal to the movement path of the ultrasonic wave generating unit.Type: GrantFiled: June 2, 2023Date of Patent: July 15, 2025Assignee: Jeisys Medical Inc.Inventors: Kyun Tae Kim, Hyun Jin Kim, Dong Hwan Kang, Won Ju Yi
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Patent number: 12343201Abstract: An endoscopic image diagnosis device having a disposable ultrasound probe is disclosed. An endoscopic image diagnosis device of the present invention has an ultrasound module provided with an ultrasound probe and detachably coupled to the front end of a scope; an ultrasound image diagnosis device electrically connected to the ultrasound probe to process an ultrasound diagnosis image; an endoscopic image diagnosis device electrically connected to the scope to process an endoscopic diagnosis image; and a display for displaying the ultrasonic diagnosis image of the ultrasonic image diagnosis device and the endoscopic diagnosis image of the endoscopic image diagnosis device, and thus the present invention can attachably/detachably use the ultrasound probe at the front end of a conventional endoscope device, so as to reduce the socioeconomic cost of transferring patients to secondary and tertiary hospitals if purchased and used by primary medical personnel who could not purchase expensive conventional equipment.Type: GrantFiled: July 13, 2021Date of Patent: July 1, 2025Assignee: UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUSInventor: Hee Man Kim
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Patent number: 12343022Abstract: Systems and methods for ultrasonically-assisted placement of orthopedic implants is described herein. An example method may comprise delivering ultrasonic energy to a surgical instrument such as a screw driver, Jamshidi needle, awl, probe, or tap that is in contact with the bone region targeted for removal and/or being prepared for implant placement. The method may further comprise delivering the ultrasonic energy via a probe passed through a cannulated surgical instrument and/or implant. An example system may comprise an ultrasonic generator coupled to a transducer, a probe or surgical instrument coupled to the transducer, a cannulated surgical instrument that allows passage of the probe, and a computing device configured to control the ultrasonic generator and take input from the user.Type: GrantFiled: August 2, 2023Date of Patent: July 1, 2025Assignee: MiRus LLCInventors: Angad Singh, Jay Yadav
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Patent number: 12290403Abstract: Systems and methods are provided for performing transcranial diagnostic procedures using a transcranial ultrasound transducer array. The array elements are positioned and oriented such that far field regions respectively associated therewith spatially overlap within the brain of a patient. The array elements may be oriented approximately normal to the skull, permitting efficient coupling of ultrasound energy into the brain. The array elements are controlled to generate ultrasound pulses, where the timing of the pulses is controlled, based on registration between the array elements and volumetric image data, such that ultrasound energy is focused at a target within spatially overlapping far fields of the array elements. The transcranial ultrasound transducer array elements may be positioned and oriented relative to the skull such that their respective ultrasound beams are focused within the skull and diverging with the brain.Type: GrantFiled: October 6, 2023Date of Patent: May 6, 2025Assignee: SUNNYBROOK RESEARCH INSTITUTEInventors: Kullervo Hynynen, Alec Hughes, Lulu Deng, Meaghan O'Reilly
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Patent number: 12279783Abstract: A system for delivering mechanical waves to treat a lesion present in a vessel of a body, including an external mechanical wave source for generating mechanical waves from outside of the body, and a wave directing device insertable in the vessel, the wave directing device configured to receive the mechanical waves generated by the external mechanical wave source and to redirect the mechanical waves according to a target direction.Type: GrantFiled: December 10, 2018Date of Patent: April 22, 2025Assignee: LES SOLUTIONS MÉDICALES SOUNDBITE INC.Inventors: Martin Brouillette, Steven Dion, Louis-Philippe Riel, Steven Arless, Marwan Abboud, Dustin Arless
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Patent number: 12263041Abstract: A signal processing pathway for an ultrasonic imaging device is provided. The signal processing pathway is configured to operate in a frequency range of 1 MHz to 40 MHz inclusive and a voltage range of ?80 V to +80 V inclusive.Type: GrantFiled: September 29, 2017Date of Patent: April 1, 2025Assignee: EXACT IMAGING INC.Inventors: Brian C. Wodlinger, Jerrold Wen, Zahra Torbatian, Simpson Lam
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Patent number: 12245892Abstract: This method for imaging in real time the propagation of a mechanical wave in an acoustically propagative medium comprises steps of: a) emitting (1000) a mechanical wave in an acoustically propagative medium, using an acoustic source being placed in an emission region of the acoustically propagative medium, b) measuring (1002) voltage signal waveform values at a reception region, using an acoustic measurement unit; c) calculating (1004) acoustic field values in the acoustically propagative medium, between the emission region and the reception region, using a reconstruction algorithm implemented in a signal processing unit, and the signal waveform values measured during step b) d) generating an image, using an image generation device and using the calculated acoustic field values.Type: GrantFiled: January 10, 2018Date of Patent: March 11, 2025Assignees: INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ CLAUDE BERNARD LYON, CENTRE LÉON-BÉRARDInventors: William Apoutou N'Djin, Kazuhiro Matsui, Françoise Chavrier, Rémi Souchon
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Patent number: 12239854Abstract: Methods and systems for acoustic treatment of tissue are provided. Acoustic energy, for example ultrasound energy, under proper functional control can penetrate deeply and be controlled precisely in tissue. Some aspects provide a method configured for removal of at least a portion of targeted tissue, such as a scar, abscess, non-cancerous tumor, or fibrous knot, in a tissue of the body.Type: GrantFiled: April 16, 2021Date of Patent: March 4, 2025Assignee: Guided Therapy Systems, LLCInventor: Michael H. Slayton
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Patent number: 12232802Abstract: The instant disclosure relates to electrophysiology catheters for tissue ablation within a cardiac muscle. In particular, the instant disclosure relates to an electrophysiology catheter that conforms to a shape of a pulmonary vein receiving ablation therapy for a cardiac arrhythmia and produces a consistent tissue ablation line along a length and circumference of the pulmonary venous tissue.Type: GrantFiled: June 25, 2021Date of Patent: February 25, 2025Assignee: St. Jude Medical, Cardiology Division, Inc.Inventor: Gregory K. Olson
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Patent number: 12214221Abstract: A method for ultrasound stimulation of spinal cord, the method comprising at least two stimulation cycles, each comprising the steps of: a) obtaining a first real-time spinal cord using a first set of ultrasound transducers; b) selecting a pre-determined stimulation area of the spinal cord from the first real-time spinal cord; c) calculating the position and orientation of the selected stimulation area relative to a second set of ultrasound transducers; and d) stimulating the selected stimulation area of the spinal cord at the calculated relative position and orientation using the second set of ultrasound transducers.Type: GrantFiled: June 21, 2017Date of Patent: February 4, 2025Assignee: THE HONG KONG POLYTECHNIC UNIVERSITYInventors: Md. Monzurul Alam, Yongping Zheng
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Patent number: 12213225Abstract: A control device, comprising: a processor including hardware, the processor being configured to: control a laser light source to emit a first instance of a laser light, calculate an overlap information related to an overlap area of an irradiation area of an irradiation target that is irradiated with the first instance of the laser light, and control the laser light source to emit a second instance of the laser light based on the overlap information.Type: GrantFiled: February 28, 2023Date of Patent: January 28, 2025Assignee: Olympus CorporationInventor: Yuhei Takata
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Patent number: 12201643Abstract: Provided herein are compositions and methods for mechanochemical dynamic therapy.Type: GrantFiled: October 14, 2022Date of Patent: January 21, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: King C. Li, Gun Kim, Qiong Wu, Jeffrey S. Moore, Yun-Sheng Chen
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Patent number: 12193970Abstract: Systems, methods and devices for utilizing heat transfer parameters or energy expenditure of devices providing controlled hypothermia, normothermia or hyperthermia to detect changes, or the absence of changes, a patient's endogenous set-point temperature; which is not available during exogenously induced targeted temperature management. A particular embodiment would allow detection of fever in patients undergoing targeted temperature managed.Type: GrantFiled: November 3, 2023Date of Patent: January 14, 2025Assignee: ZOLL Circulation, Inc.Inventors: Norman A. Paradis, B. Stuart Trembly
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Patent number: 12194319Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.Type: GrantFiled: June 30, 2023Date of Patent: January 14, 2025Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Rinat O. Esenaliev, Maria-Adelaide Micci, Donald S. Prough
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Patent number: 12186593Abstract: Improved acoustic neurostimulation is provided by having two or more acoustic transducers generate an acoustic interference pattern in a region of a patient being treated. The apparatus has at least two operating modes it can switch between. A first operating mode has the transducers driven at the same frequency. A second operating mode has the transducers driven at different frequencies. Full control of the acoustic transducers allows the acoustic interference pattern to be varied electronically at will.Type: GrantFiled: June 5, 2020Date of Patent: January 7, 2025Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Michael D. Menz, Butrus T. Khuri-Yakub, Stephen A. Baccus, Patrick Ye, Kim Pauly, Kamyar Firouzi, Morten F. Rasmussen, Omer Oralkan, Amin Nikoozadeh
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Patent number: 12165626Abstract: In a wave focusing device and a wave emitting device having the wave focusing device, the wave focusing device has a plurality of filters and focuses a wave by a phase overlap. The plurality of filters includes a first filter formed on a substrate, a second filter formed on the substrate and overlapping with the first filter in a first area, and a third filter formed on the substrate and overlapping with the second filter in a second area. A size of the first area is substantially same as that of the second area. A first portion of the second filter in the first area is inverted to a second portion of the second filter in the second area, with respect to a first axis. A wave passing through the wave focusing device is focused at a center of each of the first, second and third filters.Type: GrantFiled: April 1, 2022Date of Patent: December 10, 2024Assignees: KOREA INSTITUTE OF MACHINERY & MATERIALS, CENTER FOR ADVANCED META-MATERIALSInventors: Jun-Ho Jeong, Hyeokjung Kang, Sohee Jeon, Soon-Hyoung Hwang, Yongrok Jeong
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Patent number: 12150702Abstract: An ablation treatment catheter may include a first conductive wire formed of a first material. The first conductive wire is configured to be connected to a power generator and to carry a current to deliver ablation energy to a biological tissue. The catheter may include a second wire coupled to the first conductive wire. The second wire formed of a second material. The second wire forming a junction with the first conductive wire. The catheter may include a first electrode comprising an ablation element and a temperature sensor. The ablation element includes part of the first conductive wire and is configured to deliver the ablation energy to the biological tissue. The temperature sensor includes the junction of the first conductive wire and the second wire such that a thermocouple is formed at the junction to measure temperature at the first electrode.Type: GrantFiled: June 4, 2024Date of Patent: November 26, 2024Assignee: PhysCade, Inc.Inventors: Sanjiv M. Narayan, Bret Anders Herscher, David Krawzsenek
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Patent number: 12144683Abstract: An ultrasound diagnosis apparatus includes: a display; a memory storing one or more instructions; and a processor configured to execute the one or more instructions stored in the memory to: acquire first elasticity data with respect to a first area of an object; generate a first elasticity image based on the first elasticity data; acquire, based on the first elasticity data, first and second elasticity values respectively corresponding to first and second regions of interest included in the first area; control the display to display the acquired first and second elasticity values; and control the display to display, when the first elasticity value is selected, the first elasticity image and the first region of interest corresponding to the first elasticity value.Type: GrantFiled: August 6, 2020Date of Patent: November 19, 2024Assignee: SAMSUNG MEDISON CO., LTD.Inventors: Sunmo Yang, Jihun Kim, Wonik Heo
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Patent number: 12133759Abstract: The invention relates to a cardiotocography girdle. It is in the form of a spherical cap and comprises at least nineteen ultrasound transducers, denoted USTs, which are positioned on a first support layer (23) made of an elastic material, each UST being positioned in a support cavity (20), said girdle comprising a second support layer (24), likewise made of an elastic material and which encapsulates said USTs housed in the support cavities (20) with the first support layer (23), assembly being performed by adhesively bonding the first support layer (23) to the second support layer (24).Type: GrantFiled: February 4, 2021Date of Patent: November 5, 2024Assignee: NATEO HEALTHCAREInventor: Celine Hardy
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Patent number: 12115027Abstract: Method and apparatus are disclosed for esophageal heat transfer devices and methods for cardiac tissue ablation procedures. An exemplary method includes collecting esophageal data via one or more sensing elements of an esophageal heat transfer device positioned within an esophagus of the patient. The exemplary method includes determining, based on the esophageal data and/or operator selected power setting, a temperature setting and/or a flow rate setting for fluid flowing through the esophageal heat transfer device to maintain a target temperature of esophageal tissue adjacent to the ablation site via a heat transfer region. The exemplary method includes adjusting, via the controller, a fluid source to provide the fluid to the esophageal heat transfer device at the temperature setting and/or a flow rate setting.Type: GrantFiled: April 3, 2019Date of Patent: October 15, 2024Assignee: Advanced Cooling Therapy, Inc.Inventors: Erik Kulstad, Jay D. Schieber
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Patent number: 12109440Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.Type: GrantFiled: July 29, 2022Date of Patent: October 8, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
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Patent number: 12102473Abstract: Embodiments provide an ultrasound treatment system. In some embodiments, the system includes a removable transducer module having an ultrasound transducer. In some embodiments, the system can include a hand wand and a control module that is coupled to the hand wand and has a graphical user interface for controlling the removable transducer module, and an interface coupling the hand wand to the control module. The interface may provide power to the hand wand or may transfer a signal from the hand wand to the control module. In some embodiments, the treatment system may be used in cosmetic procedures on at least a portion of a face, head, neck, and/or other part of a patient.Type: GrantFiled: June 27, 2023Date of Patent: October 1, 2024Assignee: Ulthera, Inc.Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
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Patent number: 12082868Abstract: A multi-pole synchronous pulmonary artery radiofrequency ablation catheter may comprise a control handle, a catheter body and an annular ring. One end of the catheter body may be flexible, and the flexible end of the catheter body may be connected to the annular ring. The other end of the catheter body may be connected to the control handle. A shape memory wire may be arranged in the annular ring. One end of the shape memory wire may extend to an end of the annular ring and the other end of the shape memory wire may pass through a root of the annular ring and be fixed on the flexible end of the catheter body. The annular ring may be provided with an electrode group. The device can be used to treat pulmonary hypertension or heart failure with pulmonary denervation.Type: GrantFiled: May 31, 2023Date of Patent: September 10, 2024Assignee: PULNOVO MEDICAL (WUXI) CO., LTD.Inventor: Shaoliang Chen
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Patent number: 12077744Abstract: The invention describes a device (10) for dispensing microbubbles (30) for cell sonoporation, comprising: a tube configured to receive a vial (20) containing a solution (26) of microbubbles (30), at least two catheters (11, 12) arranged inside the tube and opening into the vial (20) when the latter is received by the tube, wherein, when the first catheter (11) is connected to a first air injection source, air can be injected into the vial (20) via the first catheter so as to generate an overpressure therein, the microbubbles (30) contained in the vial (20) entering the second catheter (12) and moving toward its second end (122). The invention also relates to a sonoporation device, a sonoporation process and a computer program product.Type: GrantFiled: September 18, 2019Date of Patent: September 3, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'ORLEANSInventors: Anthony Delalande, Matthias Lebertre, Michaël Delalande, Chantal Pichon
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Patent number: 12053198Abstract: An apparatus for tissue ablation according to an embodiment of the present disclosure includes an ultrasound output unit to output focused ultrasound, and a control unit to control an intensity of the focused ultrasound, wherein the control unit may be configured to control the intensity of the focused ultrasound below a setting value, when a first condition in which a vapor bubble is formed in a tissue or a second condition in which a temperature of the tissue reaches a threshold is accomplished during the output of the focused ultrasound to the tissue. According to this embodiment, it is possible to precisely control vapor bubble dynamics without generating the shockwave scattering effect by instantaneously controlling the acoustic pressure and the intensity of the focused ultrasound, and prevent damage to a tissue other than a lesion to be removed.Type: GrantFiled: April 24, 2020Date of Patent: August 6, 2024Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Ki Joo Pahk, Hyung Min Kim, Byung Chul Lee, Inchan Youn
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Patent number: 12053222Abstract: The disclosed technology is directed to a treatment system comprises a power supply apparatus and a treatment instrument configured to communicate electrically with the power supply apparatus so as to perform a treatment on a biological tissue. The treatment instrument includes an end effector that transmits a high-frequency current delivered by a first electrical energy to the biological tissue. An electric element is configured to operate the end effector by being actuated using second electric energy. The power supply apparatus includes a processor configured to receive a stop command to cutoff the supply of the first electric energy and the second electric energy in a state in which the first electric energy and the second electric energy are supplied and determine whether or not the end effector is in contact with the biological tissue based on a parameter related to the first electric energy after receiving the stop command.Type: GrantFiled: December 20, 2019Date of Patent: August 6, 2024Assignee: OLYMPUS CORPORATIONInventors: Ryu Onuma, Kenichi Kimura, Tsunetaka Akagane, Satoshi Honda
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Patent number: 12035966Abstract: A method for controlled ablation of target tissue includes activating laser ablation of hyperkeratotic tissue upon detecting a trigger input signal, detecting a photo-acoustical signature due to the laser ablation of the hyperkeratotic tissue, detecting a change in the photo-acoustical signature due to the laser ablation of a material different than the hyperkeratotic tissue, and ceasing the laser ablation upon detecting, by a signal processor, the change in the photo-acoustical signature.Type: GrantFiled: May 30, 2020Date of Patent: July 16, 2024Assignee: International Business Machines CorporationInventors: James J. Wynne, Jerome M. Felsenstein, Robert S. Olyha, Jr.
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Patent number: 12017093Abstract: Methods and systems confirm the treatment focus location of ultrasound energy to be delivered to a patient from a plurality of transducers. The location of focus of treatment ultrasound may be confirmed prior to the start of ultrasound therapy. In some embodiments, ultrasound therapy may comprise delivering treatment ultrasound energy from the treatment ultrasound transducers through the skull to the brain of a patient. Methods for confirming the treatment ultrasound focus location comprise determining receive focus profiles ?x,vi for particular candidate three-dimensional (3D) treatment focus locations and particular assumed ultrasound propagation velocity profiles; performing a pre-treatment (e.g. low-power) ultrasound transmission into the brain of the patient; receiving return signals; and determining the location of treatment focus based at least in part on the received return signals and the receive focus profiles ?x,vi.Type: GrantFiled: July 25, 2023Date of Patent: June 25, 2024Assignee: Cordance Medical Inc.Inventors: Bhaskar S. Ramamurthy, Mallika Keralapura, John Douglas Marshall
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Patent number: 11998764Abstract: The present disclosure provides an extracorporeal focused ultrasound treatment device for a pelvic disease. The treatment device includes an ultrasonic transducer and a treatment couch. Sound emitting surface of the ultrasonic transducer is a spherical surface having a first notch, a second notch and a third notch, the first notch and the second notch are respectively positioned at two intersections of the spherical surface and a diameter perpendicular to the main great circle, and the third notch connects the first notch with the second notch; a cross-section of the sound emitting surface parallel to the main great circle is in a shape of an arc; and an ultrasonic wave generated by the sound generation unit is focused at a center of the sphere corresponding to the sound emitting surface. The treatment couch is configured for a human body to lie in a lithotomy position.Type: GrantFiled: September 7, 2018Date of Patent: June 4, 2024Assignee: CHONGQING HAIFU MEDICAL TECHNOLOGY CO., LTD.Inventors: Hongbing Hu, Fangwei Ye, Bing Fu, Zhengming Cheng, Ying Zou, Hongjun Wen, Xiaobing Wu, Liang Hu, Haoran Huang, Jun Sun, Zheng Hu, Wenying Ma
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Patent number: 11980447Abstract: An esophageal deflection device includes an elongate outer tube that has a natural curved deflection at a position that corresponds to a targeted esophagus region for deflection. The outer diameter of the outer tube is substantially matched to an inner diameter of the esophagus to closely contact the esophagus wall, or is at least half of the inner diameter, or is smaller and includes suction ports for drawing the esophagus wall inward. An insertion rod or tube includes a portion that is stiffer than the curved deflection, and slides into the elongate outer tube to straighten the tube and can serve to guide the deflection device into an esophagus. Subsequent withdrawal of the insertion tube or rod will allow the curved deflection to return to its natural shape and deflect the targeted region of the esophagus.Type: GrantFiled: March 8, 2018Date of Patent: May 14, 2024Assignee: The Regents of the University of CaliforniaInventors: Karcher Morris, Anay Mahesh Pandit, Thomas Savides, Young Seo, Frank Talke, Youyi Fu, Greg Feld, Scott Garner
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Patent number: 11957697Abstract: Disclosed is a viral receptor that contains a sialic acid compound at one side thereof to provide binding affinity to a virus, and contains a lipid at the other side thereof, and that can be widely used for the treatment of viral infections based on this characteristic.Type: GrantFiled: September 17, 2021Date of Patent: April 16, 2024Assignee: MVRIX CO., LTD.Inventors: Woo Jae Chung, Dae Hyuk Kweon, Jinhyo Chung, Caleb Hong
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Patent number: 11944848Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.Type: GrantFiled: July 29, 2022Date of Patent: April 2, 2024Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
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Patent number: 11918652Abstract: An acoustic wave medical treatment of a body part of an individual in which nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part. The acoustic wave is sequentially applied on the body part, and/or the nanoparticles are magnetosomes. Also, compositions that include these nanoparticles.Type: GrantFiled: November 29, 2018Date of Patent: March 5, 2024Assignee: NANOBACTERIEInventor: Edouard Alphandery
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Patent number: 11896821Abstract: A method for aesthetic soft tissue treatment includes placing at least one applicator in contact with the patient's body. The applicator has at least one electrode. Electrotherapy and radio frequency therapy are provided to the soft tissue, optionally with overlay or sequentially. A handheld applicator may be used, with the applicator moving during the therapy, which may provide muscle stimulation in the patient, or provide an analgesic effect during the treatment. A spacing object may be positioned between the skin of the patient and the applicator.Type: GrantFiled: April 7, 2023Date of Patent: February 13, 2024Assignee: BTL Healthcare Technologies A.S.Inventor: Tomás Schwarz
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Patent number: 11890493Abstract: Systems and methods for transvaginal high intensity concentrated ultrasound. Urinary incontinence is treated through application of high intensity ultrasound to tissue structures to affect a change in the tissue.Type: GrantFiled: May 15, 2019Date of Patent: February 6, 2024Assignee: Acoustic Medsystems, Inc.Inventor: Everette C. Burdette
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Patent number: 11844722Abstract: Systems, methods and devices for utilizing heat transfer parameters or energy expenditure of devices providing controlled hypothermia, normothermia or hyperthermia to detect changes, or the absence of changes, a patient's endogenous set-point temperature; which is not available during exogenously induced targeted temperature management. A particular embodiment would allow detection of fever in patients undergoing targeted temperature managed.Type: GrantFiled: March 31, 2021Date of Patent: December 19, 2023Assignee: ZOLL Circulation, Inc.Inventors: Norman A. Paradis, B. Stuart Trembly
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Patent number: 11819881Abstract: A micromachined ultrasonic transducer (MUT) which comprises a first piezoelectric layer and a second piezoelectric layer. The first piezoelectric layer is disposed between a first electrode and a second electrode. The second piezoelectric layer is disposed between the second electrode and a third electrode. At least the first electrode has first and second ends along a first axis, one or more of which is defined by a radius of curvature R. A second axis normal to the first passes through a midpoint of the first axis. A half-width of the first electrode is defined by a length L measured from the midpoint, in the direction of the second axis, to an outer perimeter of the first electrode. A total width of the first electrode at its narrowest point along the first axis is at most 2L such that the first electrode has a concave shape. R/L, is greater than 1.Type: GrantFiled: June 30, 2021Date of Patent: November 21, 2023Assignee: Exo Imaging, Inc.Inventors: Haesung Kwon, Brian Bircumshaw, Sandeep Akkaraju
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Patent number: 11813485Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.Type: GrantFiled: January 28, 2021Date of Patent: November 14, 2023Assignees: The Regents of the University of Michigan, The United States Government as represented by the Department of Veterans AffairsInventors: Zhen Xu, Clifford Suhyun Cho
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Patent number: 11806874Abstract: A robot system includes a robot including rotary joints to be rotated and driven about axes by a motor, and a control device that controls the motor based on external force torque about the axes that acts on each of the respective rotary joints, a force point to apply external force is preset to the robot, and the control device calculates distances from the axes of the rotary joints to the force point based on angles of the rotary joints of the robot, and adjusts and increases an operation amount to the motor as the calculated distances decrease.Type: GrantFiled: September 11, 2020Date of Patent: November 7, 2023Assignee: FANUC CORPORATIONInventor: Shintarou Hori
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Patent number: 11786259Abstract: Systems and methods for ultrasonically-assisted placement of orthopedic implants is described herein. An example method may comprise delivering ultrasonic energy to a surgical instrument such as a screw driver, Jamshidi needle, awl, probe, or tap that is in contact with the bone region targeted for removal and/or being prepared for implant placement. The method may further comprise delivering the ultrasonic energy via a probe passed through a cannulated surgical instrument and/or implant. An example system may comprise an ultrasonic generator coupled to a transducer, a probe or surgical instrument coupled to the transducer, a cannulated surgical instrument that allows passage of the probe, and a computing device configured to control the ultrasonic generator and take input from the user.Type: GrantFiled: May 27, 2020Date of Patent: October 17, 2023Assignee: MiRus LLCInventors: Angad Singh, Jay Yadav
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Patent number: 11770816Abstract: A communication system includes multiple nodes of a time-sensitive network and a scheduler device. At least one of the nodes is configured to obtain a first signal that is represented in a frequency domain by multiple frequency components. The scheduler device generates a schedule for transmission of signals including the first signal within the time-sensitive network. The schedule defines multiple slots assigned to different discrete frequency sub-bands within a frequency band. The slots have designated transmission intervals. The nodes are configured to transmit the first signal through the time-sensitive network to a listening device such that the first signal is received at the listening device within a designated time window according to the schedule. At least some of the frequency components of the first signal are transmitted through the time-sensitive network within different slots of the schedule based on the frequency sub-bands assigned to the slots.Type: GrantFiled: December 23, 2020Date of Patent: September 26, 2023Assignee: General Electric CompanyInventors: Stephen Francis Bush, Guillaume Mantelet
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Patent number: 11730058Abstract: In some embodiments, a piezoelectric device is provided. The piezoelectric device includes a semiconductor substrate. A first electrode is disposed over the semiconductor substrate. A piezoelectric structure is disposed on the first electrode. A second electrode is disposed on the piezoelectric structure. A heating element is disposed over the semiconductor substrate. The heating element is configured to heat the piezoelectric structure to a recovery temperature for a period of time, where heating the piezoelectric structure to the recovery temperature for the period of time improves a degraded electrical property of the piezoelectric device.Type: GrantFiled: May 16, 2019Date of Patent: August 15, 2023Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Alexander Kalnitsky, Chun-Ren Cheng, Chi-Yuan Shih, Kai-Fung Chang, Shih-Fen Huang, Yi-Chuan Teng, Yi Heng Tsai, You-Ru Lin, Yan-Jie Liao
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Patent number: 11717365Abstract: A LUS robotic surgical system is trainable by a surgeon to automatically move a LUS probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2D ultrasound image slices captured by the LUS probe according to stored instructions are processable into a 3D ultrasound computer model of an anatomic structure, which may be displayed as a 3D or 2D overlay to a camera view or in a PIP as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. Virtual fixtures are definable so as to assist the surgeon in accurately guiding a tool to a target on the displayed ultrasound image.Type: GrantFiled: July 11, 2022Date of Patent: August 8, 2023Assignee: Intuitive Surgical Operations, Inc.Inventors: Christopher J. Hasser, Russell H. Taylor, Joshua Leven, Michael Choti
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Patent number: 11696791Abstract: A surgical instrument connectable to a surgical energy module that is configured to provide a first drive signal at a first frequency range for driving a first energy modality and a second drive signal at a second frequency range for driving a second energy modality is provided. The surgical instrument can comprise a surgical instrument component configured to receive power from a direct current (DC) power source, an end effector, and a circuit. The circuit can be configured to convert the first electrical signal to a DC voltage, apply the DC voltage to the surgical instrument component, and deliver the second energy modality to the end effector according to the second drive signal. Alternatively, the circuit can be disposed within a cable assembly configured to connect the surgical instrument to the surgical energy module.Type: GrantFiled: September 5, 2019Date of Patent: July 11, 2023Assignee: Cilag GmbH InternationalInventors: Joshua Henderson, Joshua P. Morgan, Andrew W. Carroll, Jeffrey L. Aldridge, Eitan T. Wiener
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Patent number: 11590370Abstract: Systems and methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Lifting sagging tissue on a face, neck, and/or body are described. Treatment with heat is provided in several embodiments.Type: GrantFiled: October 27, 2020Date of Patent: February 28, 2023Assignee: Guided Therapy Systems, LLCInventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
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Patent number: 11531207Abstract: According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI-glutamate and/or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications.Type: GrantFiled: December 18, 2017Date of Patent: December 20, 2022Assignee: The Trustees of Columbia University in the City of New YorkInventors: Volodymyr Nikolenko, Rafael Yuste, Brendon O. Watson, Darcy Peterka
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Patent number: 11490601Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for self-calibrating ultrasonic removal of sea lice. In some implementations, a method includes generating, by transducers distributed in a sea lice treatment station, a first set of ultrasonic signals, detecting a second set of ultrasonic signals in response to propagation of the first set of ultrasonic signals through water, determining propagation parameters of the sea lice treatment station based on the second set of ultrasonic signals that were detected, obtaining an image of a sea louse on a fish in the sea lice treatment station, determining, from the image, a location of the sea louse in the sea lice treatment station, and generating a third set of ultrasonic signals that focuses energy at the sea louse.Type: GrantFiled: December 23, 2020Date of Patent: November 8, 2022Assignee: X Development LLCInventors: Grace Calvert Young, Matthew Aaron Knoll, Bryce Jason Remesch, Peter Kimball
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Patent number: 11446523Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.Type: GrantFiled: March 29, 2020Date of Patent: September 20, 2022Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
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Patent number: 11439462Abstract: A system and method for laser skin resurfacing is provided. The system comprises a topical numbing composition, cryogenically cooled air, a fractional laser, and one or more topical compositions. The topical numbing composition and the cryogenically cooled air are operative to reduce patient pain and discomfort. The cryogenically cooled air is further operative to protect the patient's skin from thermal damage. The fractional laser is operative to ablate the patient's skin cells. The method comprises the steps of applying a topical numbing composition to an area of a patient's skin comprising the treatment area; directing cryogenically cooled air and a fractional laser to the treatment area; and applying one or more topical compositions to the treatment area.Type: GrantFiled: October 15, 2019Date of Patent: September 13, 2022Inventor: Simon Ourian
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Patent number: 11428808Abstract: Some embodiments of the present disclosure relate to the technical field of ultrasonic detection, and disclose an ultrasonic detection method, an ultrasonic detection system, and a related apparatus. The ultrasonic detection method includes: acquiring a reflected ultrasonic signal transmitted by an ultrasonic detector; generating an ultrasonic image according to the reflected ultrasonic signal, and displaying the ultrasonic image; acquiring information of a mark input by an operator based on the ultrasonic image; determining a marking position according to the information of the mark; transmitting the marking position to the ultrasonic detector, for the ultrasonic detector to indicate a corresponding position of the marking position on a surface of a detected object. The present disclosure resolves problems such as difficulty in operating on the surface of the detected object during ultrasonic detection and a low success rate of operation.Type: GrantFiled: September 13, 2019Date of Patent: August 30, 2022Assignee: CLOUDMINDS (SHENZHEN) HOLDINGS CO., LTD.Inventors: Lei Luo, Qingwei Ji