Hyperthermia Patents (Class 601/3)
  • Patent number: 10695135
    Abstract: The present invention relates to a non-invasive positioning system for screwing and fixing a bone, where a intramedullary nail is inserted to marrow of the bone, and the intramedullary nail comprises a wall and at least one through-hole through the wall for screwing and fixing by at least one corresponding set screw, the system comprises: an in vitro locator having at least one light source to emit a laser with a wavelength to the muscle tissue to form an incident light and running through the muscle tissue and the bone to form a penetrated light, an optical holder having an optical lens and a positioning ring portion for removably disposing the optical lens, wherein the focusing spot of the incident light, the focusing spot of the penetrated light, and the at least one through-hole are aligned in a line to confirm a linear position for screwing and fixing the intramedullary nail.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: June 30, 2020
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yin-Chih Fu, Jau-Sheng Wang, Tien-Ching Lee, Mei-Ling Ho, Wei-Chi Chen
  • Patent number: 10561862
    Abstract: In some embodiments, an ultrasound treatment system can comprise: a ultrasound transducer comprising a subdivided surface comprising a plurality of electronically isolated pieces; a power source coupled to at least two of the pieces, wherein the power supply is configured to independently shape a temporal delay or a spatial delay, as compared to each other, of acoustic energy emitted from the at least two pieces; wherein each of the at least two pieces shape the acoustic energy, independently, into a thermal zone in subcutaneous tissue.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 18, 2020
    Assignee: Guided Therapy Systems, LLC
    Inventor: Michael H Slayton
  • Patent number: 10525288
    Abstract: A method and system for noninvasive face lifts and deep tissue tightening are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat the SMAS region. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the SMAS region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 7, 2020
    Assignee: Guided Therapy Systems, LLC
    Inventors: Michael H. Slayton, Peter G. Barthe, Inder Raj S. Makin, Brian D. O'Connor
  • Patent number: 10500128
    Abstract: An apparatus for generating an acoustic energy pulse and delivering it into a body is described. The apparatus includes a generator for creating an acoustic energy pulse having an energy density field that can be measured at all points within a space in the shape of an imaginary cylinder having a length greater than or equal to 2 cm and a diameter. The cylindrically shaped space has a cylinder longitudinal axis oriented relative to a longitudinal axis of the energy pulse at an angle in the range from zero to twenty degrees. A minimum energy density for the pulse at all locations within the cylindrically shaped space is at least 50% of a maximum energy density for the pulse within the space.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 10, 2019
    Assignee: Acoustic Wave Cell Therapy, Inc.
    Inventors: Charles R. Engles, Yung Chen Su
  • Patent number: 10390877
    Abstract: Systems and methods are disclosed for treating back pain associated with a vertebral body of a patient. The system may include an external energy source configured to be positioned at a location external to the body of the patient, a linear configured to drive translation of the external source in one or more axes, a computer coupled to the external source and linear drive and programming executable on said computer for determining a target treatment site within or near the vertebral body based on acquired imaging data, positioning a focal point of the external energy source to substantially coincide with the target treatment site, and delivering a treatment dose of therapeutic energy at said target treatment site, wherein the treatment dose is configured to modulate a nerve within or near the vertebral body.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 27, 2019
    Assignee: Relievant Medsystems, Inc.
    Inventors: Michael H Heggeness, Richard C Pellegrino, Rex Peters
  • Patent number: 10300306
    Abstract: The present invention provides n ultrasonic treatment device (10) for heating a portion of a subject of interest, comprising a ultrasonic irradiation unit (12) for generating high-intensity focused ultrasonic irradiation, whereby a beam path of the ultrasonic irradiation is movable along a trajectory for depositing ultrasonic energy within a target zone (22) of the subject of interest, and a control unit (20) for controlling the ultrasonic irradiation unit (12) to move the beam path of the ultrasonic irradiation along the trajectory and to apply an ultrasonic dose to the target zone (22), wherein the control unit (20) is adapted to receive temperature information of the target zone (22) and to control the ultrasonic irradiation unit (12) based on the received temperature information, and the control unit (20) is adapted to control the ultrasonic irradiation unit (12) based on the temperature of a current (26) and at least one previous direction (28) of the beam path of the ultrasonic irradiation along the tra
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 28, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Charles Mougenot
  • Patent number: 10299818
    Abstract: A device (1) for treatments of endoscopic resection/removal of tissues, includes: a handpiece apt to be held by an user; an external tubular element (3) having a proximal end, a distal end and a cutting aperture disposed at the distal end; an internal tubular element (4) apt to be pivotally housed in the external tubular element (3) and having a proximal end, a distal end and a cutting tip at its distal end. The device also includes guide elements (5) for rotating and/or oscillating the internal tubular element (4) with respect to the external tubular element (3). The guide elements (5) include an electric motor (19) and electric feeding element for the electric motor (19) and are contained completely inside the handpiece (2).
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: May 28, 2019
    Assignee: FRII SA
    Inventor: Raffaele Riva
  • Patent number: 10251657
    Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: April 9, 2019
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Adam D. Maxwell, Bryan W. Cunitz, Wayne Kreider, Oleg A. Sapozhnikov, Ryan S. Hsi, Michael R. Bailey
  • Patent number: 10232161
    Abstract: An ultrasonic device for transversely manipulating drug delivery carriers includes a driving unit and a transducer. The transducer is electrically connected to the driving unit and has a piezoelectric sheet in a curved shape. The piezoelectric sheet includes a plurality of channels, and a phase difference is generated between every two of the channels by the driving unit for producing an acoustic vortex.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: March 19, 2019
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Wei-Chen Lo, Chih-Kuang Yeh, Shih-Tsung Kang, Zong-Han Hsieh
  • Patent number: 10143489
    Abstract: A treatment method and medical device are disclosed for cutting a substance inside a body lumen. The medical device includes a drive shaft that is rotatable; a strut that is rotatably connected to a distal side of the drive shaft, that extends along a rotation axis, and whose central portion is expandable radially outward; and a support portion that is rotatably connected to the distal side of the drive shaft, that is formed in a mesh shape and a tubular shape while including multiple gaps, at least a portion of which is positioned on a radially inner side of the strut, and that is expandable radially outward by a central portion in a direction extending along the rotation axis being bent.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: December 4, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Junichi Kobayashi, Tomonori Hatta, Taiga Nakano
  • Patent number: 10117669
    Abstract: A treatment medical and medical device are disclosed for cutting a substance inside a body lumen. The medical device includes a drive shaft that is rotatable; a strut that is rotatably connected to a distal side of the drive shaft, that extends along a rotation axis, and whose central portion is expandable radially outward; and a support portion that is rotatably connected to the distal side of the drive shaft, that is formed in a mesh shape and a tubular shape while including multiple gaps, at least a portion of which is positioned on a radially inner side of the strut, and that is expandable radially outward by a central portion in a direction extending along the rotation axis being bent.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: November 6, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Junichi Kobayashi, Tomonori Hatta, Taiga Nakano
  • Patent number: 10099044
    Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: October 16, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Balasundar Iyyavu Raju, Christopher Stephen Hall, Ralf Seip, Todd Nicholas Erpelding
  • Patent number: 10039599
    Abstract: Medical devices and methods for making and using the same are disclosed. An example method may include a method for treating tissue near a body passageway using an apparatus including a catheter having a plurality of electrodes, a radio-frequency energy generator, and a controller coupling the energy generator to the plurality of electrodes and configured to selectively energize the electrodes. The method may include using the apparatus to subject the tissue near the body passageway to a plurality of energy treatment cycles. The treatment cycle may include determining desired voltages for at least a subset of the electrodes for maintaining a predetermined target temperature profile proximate the subset of electrodes, setting an output voltage of the energy generator to correspond to the desired voltage determined for one of the electrodes, and energizing at least some of the electrodes at the output voltage to deliver energy to the body passageway.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: August 7, 2018
    Assignee: Vessix Vascular, Inc.
    Inventor: Prabodh Mathur
  • Patent number: 9981148
    Abstract: Disclosed are thermal treatment methods that involve monitoring and/or actively adjusting the temperature of targeted and/or non-targeted tissues.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: May 29, 2018
    Assignee: INSIGHTEC, LTD.
    Inventors: Kobi Vortman, Shuki Vitek, Yoav Levy
  • Patent number: 9888881
    Abstract: Methods and structures for detecting a physiologic parameter of a target anatomical environment. The device including a housing with a distal portion first port couplable to a probe and a proximal portion; and a sensing unit, a processing unit, and an output unit carried by the housing, the output unit configured to output a reporting signal based on the determined physiologic parameter value such as pressure; the sensing unit, processing unit, and output unit being disposed substantially between the first port and the proximal portion of the housing.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: February 13, 2018
    Assignee: Mirador Biomedical
    Inventors: Justin Hulvershorn, Karl Schmidt, Douglas Swartz
  • Patent number: 9852619
    Abstract: A method for operating an ultrasonic appliance (1), which ultrasonic appliance has an ultrasonic generator (2) and an ultrasonic oscillator (4) that has an electrical operative connection to the ultrasonic generator, wherein the ultrasonic generator supplies electric power to an ultrasonic transducer that the ultrasonic oscillator contains and stimulates said ultrasonic transducer to produce ultrasound. The proposed method is distinguished in that the ultrasonic oscillator and the ultrasonic generator communicate with one another (K1, K2), preferably digitally, via an operative data and/or signal connection, wherein the ultrasonic oscillator transmits identification data to the ultrasonic generator, which identification data allow the ultrasonic generator to recognize the ultrasonic oscillator. Furthermore, a communication device—suitable for carrying out said method—for an ultrasonic appliance and an ultrasonic appliance having such a communication device are provided.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: December 26, 2017
    Assignee: Weber Ultrasonics GmbH
    Inventor: Ralf Broszeit
  • Patent number: 9833165
    Abstract: Cardiac ablation is monitored to detect hemopericardium by iteratively acquiring magnetic resonance imaging (MRI) data that includes the pericardium, measuring the pericardium by analyzing the sets of MRI data, making a determination that a measurement of the pericardium in consecutive sets of MRI data differ, and responsively to the determination reporting a change in configuration of the pericardium.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 5, 2017
    Assignee: Biosense Webster (ISRAEL) Ltd.
    Inventors: Yitzhack Schwartz, Assaf Govari, Vadim Gliner
  • Patent number: 9833640
    Abstract: Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: December 5, 2017
    Assignee: Guided Therapy Systems, L.L.C.
    Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
  • Patent number: 9808239
    Abstract: A device for the transosseous insertion of suture threads comprises: —a main body (1), equipped with a grip (2), supporting a protruding cannula (3) provided with an active end (30); —a flexible thread-like element (4) which is housed in a coaxially sliding manner inside the cannula (3) and is suitable, on command, for exiting from the active end (30) of the cannula (3). The thread-like element (4) is made of a super-elastic, shape-memory material and thus has the property of freely assuming, at least in an adequate temperature range for which its operative use is foreseen, a natural and predetermined curved form at least in a determined portion of the terminal part thereof. Means are provided for producing the coaxial movement of the thread-like element (4) in the two directions relative to the cannula (3).
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: November 7, 2017
    Assignee: NCS LAB S.R.L.
    Inventor: Matteo Mantovani
  • Patent number: 9782324
    Abstract: Systems and methods for treating facial soft tissues of a patient in a healthcare or cosmetic treatment environment such as, for example, a spa, clinic, or a medical practitioner's office are presented herein. The facial treatment system includes a facial stimulator instrument and/or an acoustic oscillator to deliver therapeutic stimulation to the facial tissues of a patient including percussive massage, electrical stimulation, and acoustic stimulation. A facial treatment application executing on a processor of a computing device identifies a treatment protocol and operates the facial stimulator instrument and/or acoustic oscillator to implement the facial tissue treatment.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: October 10, 2017
    Assignee: Sigma Instruments Holdings, LLC
    Inventors: John Crunick, Tamas Becse, Louis L. Laskey, Jr.
  • Patent number: 9770280
    Abstract: A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: September 26, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chris J. Diederich, Jeffrey C. Lotz, William H. Nau, Jr., David S. Bradford
  • Patent number: 9700742
    Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: July 11, 2017
    Assignee: University of Washington
    Inventors: Michael S. Canney, Michael R. Bailey, Lawrence A. Crum, Vera A. Khokhlova, Tatiana D. Khokhlova, Wayne Kreider, Joo Ha Hwang, Oleg A. Sapozhnikov
  • Patent number: 9649511
    Abstract: An ultrasonic irradiation device 10 includes: an ultrasonic irradiation pad 110 including at least two output elements for emitting supersonic waves with output strength in a range of 50±5 mW/cm2 to 110±5 mW/cm2 at output frequency in a range of 500±50 kHz to 800±50 kHz; drive control device 11 that drivingly controls the ultrasonic irradiation pad 110; and fastening device 120 that fastens the ultrasonic irradiation pad 110 in a state of being in close contact with a forearm 50 of the living body, in which the fastening device 120 is formed into a deformable strip having a removable fixed portion 120a in an end portion.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: May 16, 2017
    Inventor: Katsunori Nonogaki
  • Patent number: 9604860
    Abstract: Provided is a technique capable of reducing power consumption at driving time in relation to a suspension processing device using an ultrasonic wave. A suspension processing device 1A is provided with a suspension processing unit 3A configured of a flow channel unit 30 in which a suspension flows, and a drive control unit 2A that controls driving of the suspension processing unit 3A. The suspension processing unit 3A has a first oscillator 40a and a second oscillator 40b provided in the flow channel unit 30. The drive control unit 2A includes a signal amplifier 22. A first oscillator 40a and a second oscillator 40b are electrically connected to each other via the signal amplifier 22, and the ultrasonic wave is generated between the first oscillator 40a and the second oscillator 40b.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 28, 2017
    Assignee: Hitachi, Ltd.
    Inventors: Takuya Kambayashi, Kentaro Nakamura
  • Patent number: 9579518
    Abstract: In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: February 28, 2017
    Assignee: Kona Medical, Inc.
    Inventor: Michael Gertner
  • Patent number: 9486651
    Abstract: The present disclosure provides for effective systems and methods for increasing target tissue conspicuity within a particular anatomy of a particular patient. In an exemplary embodiment, a system associated with the present disclosure includes: (a) a MRI-guided HIFU system for generating ablation markings on a target tissue region, the MRI-guided HIFU system including a transducer for delivering HIFU to the target tissue region, the delivered HIFU generating the ablation markings on the target tissue and an MRI imaging system adapted to generate a three dimensional image of the target tissue region during HIFU delivery for guiding the delivery of the HIFU to the target tissue region; (b) a radiotherapy delivery system for delivering radiotherapy treatment to the target tissue region; and (c) a CT imaging system operable within the radiotherapy delivery system for generating a three dimensional image of the target tissue region.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 8, 2016
    Assignees: KONINKLIJKE PHILIPS N.V., THE UNIVERSITY OF CHICAGO
    Inventors: Gregory Karczmar, Shunmugavelu Sokka, Charles A. Pelizzari
  • Patent number: 9302125
    Abstract: Methods and apparatus are provided that enable a physician to image tissue within the body that is to be ablated, and then to ablate that tissue using a device having an ultrasound imaging system and an aligned high intensity focused ultrasound system.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: April 5, 2016
    Assignee: The Foundry, LLC
    Inventors: Hanson S. Gifford, Mark E. Deem
  • Patent number: 9242121
    Abstract: An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located.
    Type: Grant
    Filed: April 2, 2011
    Date of Patent: January 26, 2016
    Assignee: CHONGQING HAIFU MEDICAL TECHNOLOGY CO., LTD.
    Inventors: Zhibiao Wang, Hua Wang, Deping Zeng, Chunliang Zhao, Fangwei Ye, Sanyong Li, Guihua Xu, Xiaobo Gong
  • Patent number: 9220476
    Abstract: An ultrasound system comprises a transducer, a controller arranged to generate control signals arranged to control the transducer to generate pressure waves directed at a target volume, and sensing means arranged to sense cavitation in the target volume. The controller is arranged to receive sensing signals from the sensing means and to vary the control signals in response to the sensing signals thereby to control the cavitation.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: December 29, 2015
    Assignee: Isis Innovation Limited
    Inventors: Constantin Coussios, Manish Arora, Natalie Hockham, Ronald Aurele Roy
  • Patent number: 9132287
    Abstract: A system and method for medical treatment of tissue using ultrasound. The system comprises a probe having an array of transducer elements, an ultrasound waveform generator adapted to generate at least one electrical ultrasound signal, and a plurality of phase controls, each coupled to the ultrasound waveform generator and adapted to generate from the electrical ultrasound signal a phase-shifted drive signal that is coupled to an associated transducer element. The drive signal is effective to control grating lobe foci emitted by the array. The method employs the system.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: September 15, 2015
    Inventors: T. Douglas Mast, Waseem Faidi, Inder Raj S. Makin, Peter G. Barthe, Michael H. Slayton
  • Patent number: 9050449
    Abstract: A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: June 9, 2015
    Assignee: Mirabilis Medica, Inc.
    Inventors: Gregory P. Darlington, Michael J. Connolly, Justin A. Reed, Jessica E. Parsons, Roland Horth, John Murkowski, Charles D. Emery
  • Publication number: 20150141876
    Abstract: An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chris J. Diederich, Jeffrey C. Lotz, Will Nau, David S. Bradford
  • Publication number: 20150141874
    Abstract: A multi-beam ultrasound device with intersecting beams is presented for use in medical therapy and industry. Multiple ultrasound beams interfere constructively and destructively depending on their phase at the target tissue, and this device and its methodology uses phase control for intensity enhancement at the beam intersection. Two among many embodiments are detailed: phase matching where the phases of the beams are determined and controlled to be equal, and phase sweeping where the phases of the beams are purposely varied.
    Type: Application
    Filed: November 18, 2013
    Publication date: May 21, 2015
    Inventor: Kitchener Clark Wilson
  • Publication number: 20150141734
    Abstract: The method determines parameters to generate confocal ultrasound beams (B1,B2) inside a medium (4), and uses a device (1) comprising first and second ultrasound means (11,12) and first and second displacement members (13,14) for moving the ultrasound means (11,12). The parameters include signals s1,s2 to the ultrasound means (11,12), and the positions x1,x2 of the ultrasound means (11,12). The parameters are optimized for having a minimum amplitude a1,a2 of the signals s1,s2 and having an acoustic effect inside the medium (4).
    Type: Application
    Filed: March 8, 2013
    Publication date: May 21, 2015
    Inventors: Jean-Yves Chapelon, Cyril Lafon, Jean-Louis Mestas
  • Publication number: 20150141875
    Abstract: Compositions and methods used in the non-invasive detection and/or treatment of hypoxic tissues in vivo are described. Compositions including microbubbles functionalized with one or more hypoxia targeting agents and one or more therapeutic compounds, methods of preparing the functionalized microbubbles, and methods of using the functionalized microbubbles for diagnostic and/or therapeutic applications are described, including a method for selectively determining the amount of vascular hypoxia occurring in a tissue.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Inventors: Nathan A. Koonce, Robert Griffin
  • Publication number: 20150133827
    Abstract: An ultrasound irradiation apparatus includes first transducers configured to irradiate first ultrasound energy upon an object with respect to a potential diagnosis and to receive an echo signal which corresponds to the irradiated first ultrasound energy, second transducers configured to irradiate second ultrasound energy upon a region of interest which is determined based on a result of processing of the received echo signal, and a contact pad configured to facilitate a contact between the first transducers and the object, and to facilitate a contact between the second transducers and the object.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 14, 2015
    Applicants: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION, SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Joonho SEO, Hotaik LEE, Wonchul BANG, Jungbae KIM, Youngsun KIM
  • Publication number: 20150133826
    Abstract: The invention provides for a medical apparatus (300, 500, 600) comprising a high intensity focused ultrasound system (302), a memory containing instructions, and a processor. Execution of the instructions causes the processor to receive (100, 202) surface data (342) descriptive of the location of a surface (322). The surface data defines the location of the heating volume. Execution of the instructions further cause the processor to determine (102, 204) a set of transducer switching commands (344) using the heating location data and an ultrasound transducer element model (352) and control (104, 206) the high intensity focused ultrasound system with the set of transducer switching commands to heat the heating volume. The set of transducer switching commands comprises an intensity level for the multiple ultrasound transducer elements either above or below a predetermined intensity for controlling a cross sectional shape of the heating volume to encompass the surface.
    Type: Application
    Filed: June 4, 2013
    Publication date: May 14, 2015
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Antti Johannes Viitala, Mika Petri Ylihautala
  • Publication number: 20150126910
    Abstract: The invention provides for a medical instrument (300, 500, 600) comprising a high intensity focused ultrasound system (302) comprising an ultrasonic transducer (306) with multiple transducer elements (400, 402, 404, 406, 408). The medical instrument further comprises a memory (334) containing machine executable instructions (350, 352, 354, 520, 522, 524) which cause a processor to receive (100, 200) a treatment plan (340) specifying a protected zone (322) within a subject (301) and to calculate (102, 208) a set of transducer control parameters (342) using the treatment plan. The set of transducer control parameters specify the switching of electrical power to the multiple transducer elements. An ultrasonic intensity estimate (900) in the protected zone is below a predetermined threshold. The ultrasonic intensity estimate is calculated using an incoherent sum of the ultrasonic pressure generated by each of the multiple transducer elements.
    Type: Application
    Filed: December 12, 2012
    Publication date: May 7, 2015
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Iipo Asko Julius Koskela, Charles Mougenot, Marko Tapani Häkkinen
  • Publication number: 20150119763
    Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 30, 2015
    Inventors: Michael S. Canney, Michael R. Bailey, Lawrence A. Crum, Vera A. Khokhlova, Tatiana D. Khokhlova, Wayne Kreider, Joo Ha Hwang, Oleg A. Sapozhnikov
  • Publication number: 20150112234
    Abstract: Devices, systems, and methods for the selective positioning of an intravascular ultrasound neuromodulation device are disclosed herein. One aspect of the present technology is directed to positioning systems for focused ultrasound devices. Some embodiments, for example, are directed to dual-balloon positioning systems. Such systems can include, for example, an elongated shaft and a therapeutic assembly and a balloon assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The balloon assembly can include a first balloon and a second balloon circumferentially offset from the first balloon about the elongated shaft. The first and second balloons can be selectively inflated to position an ultrasound transducer of the therapeutic assembly at a precise location within the blood vessel.
    Type: Application
    Filed: October 18, 2013
    Publication date: April 23, 2015
    Inventors: Gerry McCaffrey, Barry O'Connell
  • Publication number: 20150112235
    Abstract: The object of the invention relates to an apparatus for the thermal treatment of biological tissues by means of the application of focused ultrasound waves, the apparatus including: a probe movement system (7) for ensuring: the moving of the focal zone (Z) along a first direction (X), from a distal point (D) of the treatment zone (T) to a proximal point (P) of the treatment zone, in order to create a sequence (S) of elementary treatment zones; the juxtaposition of sequences (S, S1, S2, S3, . . . ) of elementary treatment zones in order to completely cover the treatment zone (T); a control circuit (6) controlling the probe (2), in order to ensure that the ultrasonic power delivered to the focal zone decreases between the distal point (D) and the proximal point (P) of the treatment zone.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 23, 2015
    Inventors: Lucie BRASSET, Jean-Yves CHAPELON, Nicolas GUILLEN, Francoise CHAVRIER, Emmanuel BLANC
  • Patent number: 9011336
    Abstract: A method and system for treating tissue with a combined therapy profile is disclosed. In one exemplary embodiment, ultrasound energy is used to treat numerous depths of tissue within a region of interest and the spatial and temporal properties of the ultrasound energy are varied for more effective treatment. The method and system of the present invention are configured to treat all of the tissue from the surface on down and not spare intervening tissue.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: April 21, 2015
    Assignee: Guided Therapy Systems, LLC
    Inventors: Michael H. Slayton, Peter G. Barthe, Inder Raj S. Makin
  • Patent number: 9014786
    Abstract: The present invention is directed to a device and method for opening obstructed body internal passages and for sensing and characterizing tissues and substances in contact with the device. In general, the device comprises a catheter tube capable of inducing vibrations in a guidewire contained therein, wherein said vibrations of the guidewire are utilized for opening a passage through an occlusion. The in-vivo vibrations may be induced by means of a magnetic field actuating means and a guidewire comprising magnetic coupling means, or by means of transducers, which may be also used for the sensing. The invention also relates to the field of minimal invasive catheterization, particularly an apparatus for opening and/or removing obstructions occluding body internal passages by means of an active guidewire comprising a coil to which an alternating voltage can be applied. In that way the guidewire can vibrate if an external magnetic field is applied.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 21, 2015
    Assignee: Eyoca Medical Ltd.
    Inventors: Ran Carmeli, Jonathan Einav, Itai Yonat
  • Publication number: 20150105701
    Abstract: The invention provides a therapeutic system comprising: a console, wherein the console comprises a controller and an energy generator; a therapeutic device comprising: an operational head configured for transmitting the energy output from to a biological tissue; and a memory device comprising control instructions, wherein said control instructions comprise instructions for controlling the console; a reversible memory operable linkage linking the memory device to the controller; and a reversible connector configured for operably linking the energy generator to the operational head. Optionally, the energy generator is a generator of ablation energy or heat energy (e.g. RF generator) and the control instructions comprise instructions for controlling the output of the energy generator. Optionally, the control instructions comprise one or more parameters of energy output or an algorithm configured for controlling the energy output.
    Type: Application
    Filed: September 24, 2014
    Publication date: April 16, 2015
    Inventors: Carl Mayer, John Ellenz
  • Patent number: 9005143
    Abstract: In some embodiments, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: April 14, 2015
    Assignee: Kona Medical, Inc.
    Inventor: Michael Gertner
  • Patent number: 8998791
    Abstract: The present invention provides a system for increasing skin rejuvenation of a region of a patient's skin comprising a pulsed electromagnetic field (PEMF) frequency generator for constantly providing electromagnetic pulses to the region of a patient's skin and a deep tissue diathermy device for constantly applying heat to the region of a patient's skin up to temperature T. The system is adapted for simultaneously applying heat and PEMF to the region of a patient's skin; wherein application of the system increases skin rejuvenation such that the skin rejuvenation increase (SRI) is greater than the sum of the SRI provided by electromagnetic pulses increase and the SRI provided by the deep tissue diathermy device increase.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: April 7, 2015
    Assignee: Venus Concept Ltd
    Inventors: Oded Ron Edoute, Orit Ron Edoute, Itzhak Kremin, Vadim Polyakov
  • Patent number: 8992447
    Abstract: A system for applying focused ultrasound energy to a nerve surrounding an artery of a patient includes a piezoelectric array comprising a plurality of piezoelectric elements, a controller configured to control at least a subset of the piezoelectric elements so that at least one of the piezoelectric elements in the subset is in a signal transmitting mode, in a signal sensing mode, or both, a first platform on which the piezoelectric elements are coupled and a second platform, wherein the second platform is configured to support at least a part of the patient, a programmable generator configured to generate output power for one or more of the piezoelectric elements, and a programmable processor configured to process a signal sensed by at least one of the piezoelectric elements.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: March 31, 2015
    Assignee: Kona Medical, Inc.
    Inventors: Michael Gertner, David Perozek, Jimin Zhang, Arash Sabet
  • Publication number: 20150088039
    Abstract: A device (1) and a method for therapeutic treatment comprising an acoustic treatment transducer (2) able to emit high intensity waves (HIFU) toward a target (3) in order to treat the target. The high intensity waves have a focal point. The device com-prises at least one detector (15) for detecting a change of tis-sue properties caused by the high intensity waves in the target (3). The device (1) further comprises at least one means for time measurement able to measure the time tmark from the beginning of the emission of a pulse of HIFU until a change of tissue properties is detected or means for detecting the frequency of appearance of changes of tissue properties.
    Type: Application
    Filed: March 14, 2013
    Publication date: March 26, 2015
    Inventors: Sylvain Yon, Francois Lacoste
  • Publication number: 20150087977
    Abstract: To implement a single-chip ultrasonic imaging solution, on-chip signal processing may be employed in the receive signal path to reduce data bandwidth and a high-speed serial data module may be used to move data for all received channels off-chip as digital data stream. The digitization of received signals on-chip allows advanced digital signal processing to be performed on-chip, and thus permits the full integration of an entire ultrasonic imaging system on a single semiconductor substrate. Various novel waveform generation techniques, transducer configuration and biasing methodologies, etc., are likewise disclosed. HIFU methods may additionally or alternatively be employed as a component of the “ultrasound-on-a-chip” solution disclosed herein.
    Type: Application
    Filed: December 5, 2014
    Publication date: March 26, 2015
    Applicant: Butterfly Network, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, Tyler S. Ralston, Gregory L. Charvat, Nevada J. Sanchez
  • Publication number: 20150088040
    Abstract: Methods and systems for treating stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis and a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth from 0 mm to 1 cm with a conformal selective deposition of ultrasound energy without damaging an intervening tissue in the range of frequencies from 2 to 50 MHz. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.
    Type: Application
    Filed: November 26, 2014
    Publication date: March 26, 2015
    Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin