Hyperthermia Patents (Class 601/3)
  • Patent number: 11490601
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for self-calibrating ultrasonic removal of sea lice. In some implementations, a method includes generating, by transducers distributed in a sea lice treatment station, a first set of ultrasonic signals, detecting a second set of ultrasonic signals in response to propagation of the first set of ultrasonic signals through water, determining propagation parameters of the sea lice treatment station based on the second set of ultrasonic signals that were detected, obtaining an image of a sea louse on a fish in the sea lice treatment station, determining, from the image, a location of the sea louse in the sea lice treatment station, and generating a third set of ultrasonic signals that focuses energy at the sea louse.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: November 8, 2022
    Assignee: X Development LLC
    Inventors: Grace Calvert Young, Matthew Aaron Knoll, Bryce Jason Remesch, Peter Kimball
  • Patent number: 11446523
    Abstract: The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.
    Type: Grant
    Filed: March 29, 2020
    Date of Patent: September 20, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Avinoam D. Bar-Zion, Atousa Nourmahnad, David Maresca, Mikhail Shapiro
  • Patent number: 11439462
    Abstract: A system and method for laser skin resurfacing is provided. The system comprises a topical numbing composition, cryogenically cooled air, a fractional laser, and one or more topical compositions. The topical numbing composition and the cryogenically cooled air are operative to reduce patient pain and discomfort. The cryogenically cooled air is further operative to protect the patient's skin from thermal damage. The fractional laser is operative to ablate the patient's skin cells. The method comprises the steps of applying a topical numbing composition to an area of a patient's skin comprising the treatment area; directing cryogenically cooled air and a fractional laser to the treatment area; and applying one or more topical compositions to the treatment area.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: September 13, 2022
    Inventor: Simon Ourian
  • Patent number: 11428808
    Abstract: Some embodiments of the present disclosure relate to the technical field of ultrasonic detection, and disclose an ultrasonic detection method, an ultrasonic detection system, and a related apparatus. The ultrasonic detection method includes: acquiring a reflected ultrasonic signal transmitted by an ultrasonic detector; generating an ultrasonic image according to the reflected ultrasonic signal, and displaying the ultrasonic image; acquiring information of a mark input by an operator based on the ultrasonic image; determining a marking position according to the information of the mark; transmitting the marking position to the ultrasonic detector, for the ultrasonic detector to indicate a corresponding position of the marking position on a surface of a detected object. The present disclosure resolves problems such as difficulty in operating on the surface of the detected object during ultrasonic detection and a low success rate of operation.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: August 30, 2022
    Assignee: CLOUDMINDS (SHENZHEN) HOLDINGS CO., LTD.
    Inventors: Lei Luo, Qingwei Ji
  • Patent number: 11419693
    Abstract: A multi-layer, super-planar laminate structure can be formed from distinctly patterned layers. The layers in the structure can include at least one rigid layer and at least one flexible layer; the rigid layer includes a plurality of rigid segments, and the flexible layer can extend between the rigid segments to serve as a joint. The layers are then stacked and bonded at selected locations to form a laminate structure with inter-layer bonds, and the laminate structure is flexed at the flexible layer between rigid segments to produce an expanded three-dimensional structure, wherein the layers are joined at the selected bonding locations and separated at other locations. A layer with electrical wiring can be included in the structure for delivering electric current to devices on or in the laminate structure.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: August 23, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Joshua B. Gafford, Samuel B. Kesner, Conor J. Walsh, Michael Karpelson, Robert J. Wood, Zivthan Dubrovsky, Benjamin I. Goldberg, Kathleen O'Donnell, Michael J. Smith
  • Patent number: 11235180
    Abstract: A method and system for noninvasive face lifts and deep tissue tightening are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat the SMAS region. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the SMAS region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: February 1, 2022
    Assignee: Guided Therapy Systems, LLC
    Inventors: Michael H. Slayton, Peter G. Barthe, Inder Raj S. Makin, Brian D. O'Connor
  • Patent number: 11235179
    Abstract: A method and system for energy-based (e.g., ultrasound treatment and/or other modalities) of skin glands are provided. An exemplary method and system for targeted treatment of skin glands, such as sweat and/or sebaceous glands, can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound (or other energy) through control of various spatial and temporal parameters. As a result, ablative energy can be deposited at the particular depth at which the skin gland population is located below the skin surface.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: February 1, 2022
    Assignee: Guided Therapy Systems, LLC
    Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
  • Patent number: 11103731
    Abstract: Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: August 31, 2021
    Assignee: INSIGHTEC, LTD.
    Inventors: Kobi Vortman, Shuki Vitek, Eyal Zadicario, Yoav Levy
  • Patent number: 11076839
    Abstract: An ultrasonic inspection phantom includes ultrasonic inspection phantom including a hydrogel including water, a polymer, and a mineral.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: August 3, 2021
    Assignee: Ricoh Company, Ltd.
    Inventors: Tatsuya Niimi, Takashi Matsumura, Takuya Saito
  • Patent number: 11058449
    Abstract: An ultrasonic surgical device including an elongate waveguide having a longitudinal axis and a distal end, and a blade extending away from the distal end of the waveguide, the blade including a curved portion that has at least five faces extending lengthwise along at least a portion of the length of the blade. Each of the faces has a width that extends perpendicular to the longitudinal axis of the waveguide and a length that extends orthogonal to the width. Each of the faces is flat across its width and is either flat along its entire length or includes one or more curved segments along its length, with each of the curved segments of an individual face being curved in the same direction. A method of fabricating an ultrasonic surgical device is also provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 13, 2021
    Assignee: REACH SURGICAL, INC.
    Inventor: Jean Beaupre
  • Patent number: 11058447
    Abstract: A surgical instrument includes a transducer configured to produce vibrations at a predetermined frequency. An ultrasonic end effector extends along a longitudinal axis and is coupled to the transducer. The ultrasonic end effector comprises an ultrasonic blade and a clamping mechanism. A controller receives a feedback signal from the ultrasonic end effector and the feedback signal is measured by the controller. A lumen is adapted to couple to a pump. The controller is configured to control fluid flow through the lumen based on the feedback signal, and the lumen is located within the ultrasonic end effector.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: July 13, 2021
    Assignee: Cilag GmbH International
    Inventor: Kevin L. Houser
  • Patent number: 11013629
    Abstract: An intraluminal device and method of fixation of an intraluminal device in a mammalian lumen or hollow organ that experiences peristalsis includes a fixation system that is adapted to resist distal migration of the intraluminal device in the lumen or hollow organ. The intraluminal device has a wall surface configured to the size and shape of a mammalian lumen or hollow organ. A fixation system is adapted to resist distal migration of the body in the lumen or hollow organ. The fixation system includes a bio-absorbable material around at least one of the elongated members.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: May 25, 2021
    Assignee: BFKW, LLC
    Inventor: Randal S. Baker
  • Patent number: 10960236
    Abstract: A method and system for noninvasive face lifts and deep tissue tightening are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat the SMAS region. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the SMAS region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: March 30, 2021
    Assignee: Guided Therapy Systems, LLC
    Inventors: Michael H. Slayton, Peter G. Barthe, Inder Raj S. Makin, Brian D. O'Connor
  • Patent number: 10933259
    Abstract: The present invention, in some embodiments thereof, relates to a devices and methods for intravascular denervation and assessment thereof and, more particularly, but not exclusively, to devices and methods for renal denervation. Some embodiments of the invention relate to an intravascular catheter configured for ultrasonic ablation of the tissue, comprising a plurality of piezoelectric transceivers. In some embodiments, an intravascular distancing device is provided, the device adapted for obtaining at least a minimal distance between an ultrasound emitting element and a tissue, such as the blood vessel wall. Some embodiments of the invention relate to assessment of renal sympathetic denervation (RSD) treatment effectiveness. Some embodiments of the invention relate to processing echo of signals, such as processing of signals to characterize physical and/or mechanical properties of the blood vessel.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: March 2, 2021
    Assignee: CardioSonic Ltd.
    Inventors: Ariel Sverdlik, Or Shabtay, Ronen Neeman, Giora Beit-Yaakov, Lilah Marziano, Avital Schauder, Marina Dubinsky, Yehuda Zadok, Jonathan Yalom
  • Patent number: 10835172
    Abstract: A device for assessing sunscreen coverage on a person includes a casing a lens assembly extending from about a front facing surface of the casing and allowing transmissivity to light energy in a wavelength range of about 300 to about 400 nm. A filter is in optical communication with the lens assembly and having a high optical density above about 390 nm and a low optical density below about 390 nm. A sensor is in optical communication with the filter, the sensor having a signal/noise ratio that is greater than about 36 db. A controller is configured for receiving input from a user to control the device. A display screen may be in communication with a controller for displaying an image associated with the filtered light.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: November 17, 2020
    Assignee: Voxelight, LLC
    Inventors: David S. Cohen, Jonathan Meyer, Wolfgang Wagner, Connie Tran, Andrew Meyer
  • Patent number: 10695135
    Abstract: The present invention relates to a non-invasive positioning system for screwing and fixing a bone, where a intramedullary nail is inserted to marrow of the bone, and the intramedullary nail comprises a wall and at least one through-hole through the wall for screwing and fixing by at least one corresponding set screw, the system comprises: an in vitro locator having at least one light source to emit a laser with a wavelength to the muscle tissue to form an incident light and running through the muscle tissue and the bone to form a penetrated light, an optical holder having an optical lens and a positioning ring portion for removably disposing the optical lens, wherein the focusing spot of the incident light, the focusing spot of the penetrated light, and the at least one through-hole are aligned in a line to confirm a linear position for screwing and fixing the intramedullary nail.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: June 30, 2020
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yin-Chih Fu, Jau-Sheng Wang, Tien-Ching Lee, Mei-Ling Ho, Wei-Chi Chen
  • Patent number: 10561862
    Abstract: In some embodiments, an ultrasound treatment system can comprise: a ultrasound transducer comprising a subdivided surface comprising a plurality of electronically isolated pieces; a power source coupled to at least two of the pieces, wherein the power supply is configured to independently shape a temporal delay or a spatial delay, as compared to each other, of acoustic energy emitted from the at least two pieces; wherein each of the at least two pieces shape the acoustic energy, independently, into a thermal zone in subcutaneous tissue.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 18, 2020
    Assignee: Guided Therapy Systems, LLC
    Inventor: Michael H Slayton
  • Patent number: 10525288
    Abstract: A method and system for noninvasive face lifts and deep tissue tightening are disclosed. An exemplary method and treatment system are configured for the imaging, monitoring, and thermal injury to treat the SMAS region. In accordance with an exemplary embodiment, the exemplary method and system are configured for treating the SMAS region by first, imaging of the region of interest for localization of the treatment area and surrounding structures, second, delivery of ultrasound energy at a depth, distribution, timing, and energy level to achieve the desired therapeutic effect, and third to monitor the treatment area before, during, and after therapy to plan and assess the results and/or provide feedback.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 7, 2020
    Assignee: Guided Therapy Systems, LLC
    Inventors: Michael H. Slayton, Peter G. Barthe, Inder Raj S. Makin, Brian D. O'Connor
  • Patent number: 10500128
    Abstract: An apparatus for generating an acoustic energy pulse and delivering it into a body is described. The apparatus includes a generator for creating an acoustic energy pulse having an energy density field that can be measured at all points within a space in the shape of an imaginary cylinder having a length greater than or equal to 2 cm and a diameter. The cylindrically shaped space has a cylinder longitudinal axis oriented relative to a longitudinal axis of the energy pulse at an angle in the range from zero to twenty degrees. A minimum energy density for the pulse at all locations within the cylindrically shaped space is at least 50% of a maximum energy density for the pulse within the space.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: December 10, 2019
    Assignee: Acoustic Wave Cell Therapy, Inc.
    Inventors: Charles R. Engles, Yung Chen Su
  • Patent number: 10390877
    Abstract: Systems and methods are disclosed for treating back pain associated with a vertebral body of a patient. The system may include an external energy source configured to be positioned at a location external to the body of the patient, a linear configured to drive translation of the external source in one or more axes, a computer coupled to the external source and linear drive and programming executable on said computer for determining a target treatment site within or near the vertebral body based on acquired imaging data, positioning a focal point of the external energy source to substantially coincide with the target treatment site, and delivering a treatment dose of therapeutic energy at said target treatment site, wherein the treatment dose is configured to modulate a nerve within or near the vertebral body.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: August 27, 2019
    Assignee: Relievant Medsystems, Inc.
    Inventors: Michael H Heggeness, Richard C Pellegrino, Rex Peters
  • Patent number: 10300306
    Abstract: The present invention provides n ultrasonic treatment device (10) for heating a portion of a subject of interest, comprising a ultrasonic irradiation unit (12) for generating high-intensity focused ultrasonic irradiation, whereby a beam path of the ultrasonic irradiation is movable along a trajectory for depositing ultrasonic energy within a target zone (22) of the subject of interest, and a control unit (20) for controlling the ultrasonic irradiation unit (12) to move the beam path of the ultrasonic irradiation along the trajectory and to apply an ultrasonic dose to the target zone (22), wherein the control unit (20) is adapted to receive temperature information of the target zone (22) and to control the ultrasonic irradiation unit (12) based on the received temperature information, and the control unit (20) is adapted to control the ultrasonic irradiation unit (12) based on the temperature of a current (26) and at least one previous direction (28) of the beam path of the ultrasonic irradiation along the tra
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 28, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Charles Mougenot
  • Patent number: 10299818
    Abstract: A device (1) for treatments of endoscopic resection/removal of tissues, includes: a handpiece apt to be held by an user; an external tubular element (3) having a proximal end, a distal end and a cutting aperture disposed at the distal end; an internal tubular element (4) apt to be pivotally housed in the external tubular element (3) and having a proximal end, a distal end and a cutting tip at its distal end. The device also includes guide elements (5) for rotating and/or oscillating the internal tubular element (4) with respect to the external tubular element (3). The guide elements (5) include an electric motor (19) and electric feeding element for the electric motor (19) and are contained completely inside the handpiece (2).
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: May 28, 2019
    Assignee: FRII SA
    Inventor: Raffaele Riva
  • Patent number: 10251657
    Abstract: Methods, computing devices, and a computer-readable medium are described herein related to fragmenting or comminuting an object in a subject using a burst wave lithotripsy (BWL) waveform. A computing device, such a computing device coupled to a transducer, may carry out functions for producing a BWL waveform. The computing device may determine a burst frequency for a number of bursts in the BWL waveform, where the number of bursts includes a number of cycles. Further, the computing device may determine a cycle frequency for the number of cycles. Yet further, the computing device may determine a pressure amplitude for the BWL waveform, where the pressure amplitude is less than or equal to 8 MPa. In addition, the computing device may determine a time period for producing the BWL waveform.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: April 9, 2019
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Adam D. Maxwell, Bryan W. Cunitz, Wayne Kreider, Oleg A. Sapozhnikov, Ryan S. Hsi, Michael R. Bailey
  • Patent number: 10232161
    Abstract: An ultrasonic device for transversely manipulating drug delivery carriers includes a driving unit and a transducer. The transducer is electrically connected to the driving unit and has a piezoelectric sheet in a curved shape. The piezoelectric sheet includes a plurality of channels, and a phase difference is generated between every two of the channels by the driving unit for producing an acoustic vortex.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: March 19, 2019
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Wei-Chen Lo, Chih-Kuang Yeh, Shih-Tsung Kang, Zong-Han Hsieh
  • Patent number: 10143489
    Abstract: A treatment method and medical device are disclosed for cutting a substance inside a body lumen. The medical device includes a drive shaft that is rotatable; a strut that is rotatably connected to a distal side of the drive shaft, that extends along a rotation axis, and whose central portion is expandable radially outward; and a support portion that is rotatably connected to the distal side of the drive shaft, that is formed in a mesh shape and a tubular shape while including multiple gaps, at least a portion of which is positioned on a radially inner side of the strut, and that is expandable radially outward by a central portion in a direction extending along the rotation axis being bent.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: December 4, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Junichi Kobayashi, Tomonori Hatta, Taiga Nakano
  • Patent number: 10117669
    Abstract: A treatment medical and medical device are disclosed for cutting a substance inside a body lumen. The medical device includes a drive shaft that is rotatable; a strut that is rotatably connected to a distal side of the drive shaft, that extends along a rotation axis, and whose central portion is expandable radially outward; and a support portion that is rotatably connected to the distal side of the drive shaft, that is formed in a mesh shape and a tubular shape while including multiple gaps, at least a portion of which is positioned on a radially inner side of the strut, and that is expandable radially outward by a central portion in a direction extending along the rotation axis being bent.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: November 6, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Junichi Kobayashi, Tomonori Hatta, Taiga Nakano
  • Patent number: 10099044
    Abstract: A device for delivery of a substance (144) using energy to protect, at a site of activation, against a side effect of another substance (156) that was delivered, is being delivered, and/or will be delivered, at another site. The activation may be non-invasive, remote and the energy beam (140) may be an ultrasound beam. A first of the substances can be activated at a particular energy level, and the second is then activated at a lower level so that a population of particles bearing the first substance is not inadvertently activated during activation of the second substance. The device may comprise a system to control the levels of energy applied.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: October 16, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Balasundar Iyyavu Raju, Christopher Stephen Hall, Ralf Seip, Todd Nicholas Erpelding
  • Patent number: 10039599
    Abstract: Medical devices and methods for making and using the same are disclosed. An example method may include a method for treating tissue near a body passageway using an apparatus including a catheter having a plurality of electrodes, a radio-frequency energy generator, and a controller coupling the energy generator to the plurality of electrodes and configured to selectively energize the electrodes. The method may include using the apparatus to subject the tissue near the body passageway to a plurality of energy treatment cycles. The treatment cycle may include determining desired voltages for at least a subset of the electrodes for maintaining a predetermined target temperature profile proximate the subset of electrodes, setting an output voltage of the energy generator to correspond to the desired voltage determined for one of the electrodes, and energizing at least some of the electrodes at the output voltage to deliver energy to the body passageway.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: August 7, 2018
    Assignee: Vessix Vascular, Inc.
    Inventor: Prabodh Mathur
  • Patent number: 9981148
    Abstract: Disclosed are thermal treatment methods that involve monitoring and/or actively adjusting the temperature of targeted and/or non-targeted tissues.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: May 29, 2018
    Assignee: INSIGHTEC, LTD.
    Inventors: Kobi Vortman, Shuki Vitek, Yoav Levy
  • Patent number: 9888881
    Abstract: Methods and structures for detecting a physiologic parameter of a target anatomical environment. The device including a housing with a distal portion first port couplable to a probe and a proximal portion; and a sensing unit, a processing unit, and an output unit carried by the housing, the output unit configured to output a reporting signal based on the determined physiologic parameter value such as pressure; the sensing unit, processing unit, and output unit being disposed substantially between the first port and the proximal portion of the housing.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: February 13, 2018
    Assignee: Mirador Biomedical
    Inventors: Justin Hulvershorn, Karl Schmidt, Douglas Swartz
  • Patent number: 9852619
    Abstract: A method for operating an ultrasonic appliance (1), which ultrasonic appliance has an ultrasonic generator (2) and an ultrasonic oscillator (4) that has an electrical operative connection to the ultrasonic generator, wherein the ultrasonic generator supplies electric power to an ultrasonic transducer that the ultrasonic oscillator contains and stimulates said ultrasonic transducer to produce ultrasound. The proposed method is distinguished in that the ultrasonic oscillator and the ultrasonic generator communicate with one another (K1, K2), preferably digitally, via an operative data and/or signal connection, wherein the ultrasonic oscillator transmits identification data to the ultrasonic generator, which identification data allow the ultrasonic generator to recognize the ultrasonic oscillator. Furthermore, a communication device—suitable for carrying out said method—for an ultrasonic appliance and an ultrasonic appliance having such a communication device are provided.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: December 26, 2017
    Assignee: Weber Ultrasonics GmbH
    Inventor: Ralf Broszeit
  • Patent number: 9833165
    Abstract: Cardiac ablation is monitored to detect hemopericardium by iteratively acquiring magnetic resonance imaging (MRI) data that includes the pericardium, measuring the pericardium by analyzing the sets of MRI data, making a determination that a measurement of the pericardium in consecutive sets of MRI data differ, and responsively to the determination reporting a change in configuration of the pericardium.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: December 5, 2017
    Assignee: Biosense Webster (ISRAEL) Ltd.
    Inventors: Yitzhack Schwartz, Assaf Govari, Vadim Gliner
  • Patent number: 9833640
    Abstract: Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: December 5, 2017
    Assignee: Guided Therapy Systems, L.L.C.
    Inventors: Peter G. Barthe, Michael H. Slayton, Inder Raj S. Makin
  • Patent number: 9808239
    Abstract: A device for the transosseous insertion of suture threads comprises: —a main body (1), equipped with a grip (2), supporting a protruding cannula (3) provided with an active end (30); —a flexible thread-like element (4) which is housed in a coaxially sliding manner inside the cannula (3) and is suitable, on command, for exiting from the active end (30) of the cannula (3). The thread-like element (4) is made of a super-elastic, shape-memory material and thus has the property of freely assuming, at least in an adequate temperature range for which its operative use is foreseen, a natural and predetermined curved form at least in a determined portion of the terminal part thereof. Means are provided for producing the coaxial movement of the thread-like element (4) in the two directions relative to the cannula (3).
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: November 7, 2017
    Assignee: NCS LAB S.R.L.
    Inventor: Matteo Mantovani
  • Patent number: 9782324
    Abstract: Systems and methods for treating facial soft tissues of a patient in a healthcare or cosmetic treatment environment such as, for example, a spa, clinic, or a medical practitioner's office are presented herein. The facial treatment system includes a facial stimulator instrument and/or an acoustic oscillator to deliver therapeutic stimulation to the facial tissues of a patient including percussive massage, electrical stimulation, and acoustic stimulation. A facial treatment application executing on a processor of a computing device identifies a treatment protocol and operates the facial stimulator instrument and/or acoustic oscillator to implement the facial tissue treatment.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: October 10, 2017
    Assignee: Sigma Instruments Holdings, LLC
    Inventors: John Crunick, Tamas Becse, Louis L. Laskey, Jr.
  • Patent number: 9770280
    Abstract: A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: September 26, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chris J. Diederich, Jeffrey C. Lotz, William H. Nau, Jr., David S. Bradford
  • Patent number: 9700742
    Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: July 11, 2017
    Assignee: University of Washington
    Inventors: Michael S. Canney, Michael R. Bailey, Lawrence A. Crum, Vera A. Khokhlova, Tatiana D. Khokhlova, Wayne Kreider, Joo Ha Hwang, Oleg A. Sapozhnikov
  • Patent number: 9649511
    Abstract: An ultrasonic irradiation device 10 includes: an ultrasonic irradiation pad 110 including at least two output elements for emitting supersonic waves with output strength in a range of 50±5 mW/cm2 to 110±5 mW/cm2 at output frequency in a range of 500±50 kHz to 800±50 kHz; drive control device 11 that drivingly controls the ultrasonic irradiation pad 110; and fastening device 120 that fastens the ultrasonic irradiation pad 110 in a state of being in close contact with a forearm 50 of the living body, in which the fastening device 120 is formed into a deformable strip having a removable fixed portion 120a in an end portion.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: May 16, 2017
    Inventor: Katsunori Nonogaki
  • Patent number: 9604860
    Abstract: Provided is a technique capable of reducing power consumption at driving time in relation to a suspension processing device using an ultrasonic wave. A suspension processing device 1A is provided with a suspension processing unit 3A configured of a flow channel unit 30 in which a suspension flows, and a drive control unit 2A that controls driving of the suspension processing unit 3A. The suspension processing unit 3A has a first oscillator 40a and a second oscillator 40b provided in the flow channel unit 30. The drive control unit 2A includes a signal amplifier 22. A first oscillator 40a and a second oscillator 40b are electrically connected to each other via the signal amplifier 22, and the ultrasonic wave is generated between the first oscillator 40a and the second oscillator 40b.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 28, 2017
    Assignee: Hitachi, Ltd.
    Inventors: Takuya Kambayashi, Kentaro Nakamura
  • Patent number: 9579518
    Abstract: In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: February 28, 2017
    Assignee: Kona Medical, Inc.
    Inventor: Michael Gertner
  • Patent number: 9486651
    Abstract: The present disclosure provides for effective systems and methods for increasing target tissue conspicuity within a particular anatomy of a particular patient. In an exemplary embodiment, a system associated with the present disclosure includes: (a) a MRI-guided HIFU system for generating ablation markings on a target tissue region, the MRI-guided HIFU system including a transducer for delivering HIFU to the target tissue region, the delivered HIFU generating the ablation markings on the target tissue and an MRI imaging system adapted to generate a three dimensional image of the target tissue region during HIFU delivery for guiding the delivery of the HIFU to the target tissue region; (b) a radiotherapy delivery system for delivering radiotherapy treatment to the target tissue region; and (c) a CT imaging system operable within the radiotherapy delivery system for generating a three dimensional image of the target tissue region.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 8, 2016
    Assignees: KONINKLIJKE PHILIPS N.V., THE UNIVERSITY OF CHICAGO
    Inventors: Gregory Karczmar, Shunmugavelu Sokka, Charles A. Pelizzari
  • Patent number: 9302125
    Abstract: Methods and apparatus are provided that enable a physician to image tissue within the body that is to be ablated, and then to ablate that tissue using a device having an ultrasound imaging system and an aligned high intensity focused ultrasound system.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: April 5, 2016
    Assignee: The Foundry, LLC
    Inventors: Hanson S. Gifford, Mark E. Deem
  • Patent number: 9242121
    Abstract: An ultrasonic transducer is disclosed, which includes one or a plurality of ultrasonic emitting units. Wavefronts of the ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are sphere surfaces with uniform radius, and the one or the plurality of ultrasonic emitting units can reflect ultrasound. The one ultrasonic emitting unit is configured to form a spherical resonant cavity, or the plurality of ultrasonic emitting units are configured to form a spherical resonant cavity collectively. An internal cavity of the spherical resonant cavity has a spherical shell shape or a cross-sectional spherical shell shape with a spherical center therein. The ultrasonic waves emitted by the one or the plurality of ultrasonic emitting units are focused on an area in which the spherical center of the spherical resonant cavity is located.
    Type: Grant
    Filed: April 2, 2011
    Date of Patent: January 26, 2016
    Assignee: CHONGQING HAIFU MEDICAL TECHNOLOGY CO., LTD.
    Inventors: Zhibiao Wang, Hua Wang, Deping Zeng, Chunliang Zhao, Fangwei Ye, Sanyong Li, Guihua Xu, Xiaobo Gong
  • Patent number: 9220476
    Abstract: An ultrasound system comprises a transducer, a controller arranged to generate control signals arranged to control the transducer to generate pressure waves directed at a target volume, and sensing means arranged to sense cavitation in the target volume. The controller is arranged to receive sensing signals from the sensing means and to vary the control signals in response to the sensing signals thereby to control the cavitation.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: December 29, 2015
    Assignee: Isis Innovation Limited
    Inventors: Constantin Coussios, Manish Arora, Natalie Hockham, Ronald Aurele Roy
  • Patent number: 9132287
    Abstract: A system and method for medical treatment of tissue using ultrasound. The system comprises a probe having an array of transducer elements, an ultrasound waveform generator adapted to generate at least one electrical ultrasound signal, and a plurality of phase controls, each coupled to the ultrasound waveform generator and adapted to generate from the electrical ultrasound signal a phase-shifted drive signal that is coupled to an associated transducer element. The drive signal is effective to control grating lobe foci emitted by the array. The method employs the system.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: September 15, 2015
    Inventors: T. Douglas Mast, Waseem Faidi, Inder Raj S. Makin, Peter G. Barthe, Michael H. Slayton
  • Patent number: 9050449
    Abstract: A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: June 9, 2015
    Assignee: Mirabilis Medica, Inc.
    Inventors: Gregory P. Darlington, Michael J. Connolly, Justin A. Reed, Jessica E. Parsons, Roland Horth, John Murkowski, Charles D. Emery
  • Publication number: 20150141875
    Abstract: Compositions and methods used in the non-invasive detection and/or treatment of hypoxic tissues in vivo are described. Compositions including microbubbles functionalized with one or more hypoxia targeting agents and one or more therapeutic compounds, methods of preparing the functionalized microbubbles, and methods of using the functionalized microbubbles for diagnostic and/or therapeutic applications are described, including a method for selectively determining the amount of vascular hypoxia occurring in a tissue.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Inventors: Nathan A. Koonce, Robert Griffin
  • Publication number: 20150141876
    Abstract: An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chris J. Diederich, Jeffrey C. Lotz, Will Nau, David S. Bradford
  • Publication number: 20150141734
    Abstract: The method determines parameters to generate confocal ultrasound beams (B1,B2) inside a medium (4), and uses a device (1) comprising first and second ultrasound means (11,12) and first and second displacement members (13,14) for moving the ultrasound means (11,12). The parameters include signals s1,s2 to the ultrasound means (11,12), and the positions x1,x2 of the ultrasound means (11,12). The parameters are optimized for having a minimum amplitude a1,a2 of the signals s1,s2 and having an acoustic effect inside the medium (4).
    Type: Application
    Filed: March 8, 2013
    Publication date: May 21, 2015
    Inventors: Jean-Yves Chapelon, Cyril Lafon, Jean-Louis Mestas
  • Publication number: 20150141874
    Abstract: A multi-beam ultrasound device with intersecting beams is presented for use in medical therapy and industry. Multiple ultrasound beams interfere constructively and destructively depending on their phase at the target tissue, and this device and its methodology uses phase control for intensity enhancement at the beam intersection. Two among many embodiments are detailed: phase matching where the phases of the beams are determined and controlled to be equal, and phase sweeping where the phases of the beams are purposely varied.
    Type: Application
    Filed: November 18, 2013
    Publication date: May 21, 2015
    Inventor: Kitchener Clark Wilson