Abstract: The present invention relates to a three-dimensional adhesive device to be attached to the body surface of a mammal comprising a microelectronic sensing system characterized by (a) a three-dimensional adhesive body made of a pressure sensitive adhesive having an upper surface and a bottom surface; (b) a microelectronic system embedded in the body of the pressure sensitive adhesive; (c) one or more cover layer(s) attached to the upper surface; and (d) optionally a release liner releasable attached to the bottom surface of the adhesive device. Suitably the microelectronic system is a microelectronic sensing system capable of sensing physical input such as pressure, vibration, sound, electrical activity (e.g. from muscle activity), tension, blood-flow, moisture, temperature, enzyme activity, bacteria, pH, blood sugar, conductivity, resistance, capacitance, inductance or other chemical, biochemical, biological, mechanical or electrical properties.

Abstract: A liner for an orthopedic or prosthetic device includes a core formed from a porous and compressible material, a first layer secured to the first side of the core and forming a first surface to the liner, and a second layer secured to the second side of the core and forming a second surface to the liner. The first and second layers may comprise different properties from one another and be formed from different materials including fabrics and polymeric materials. A polymeric film may be secured to the core or one of the layers to define at least part of a surface of the liner.

Abstract: A dressing for treating a tissue site may include a base layer, a sealing member, a first and a second wicking layer, and an absorbent layer. The base layer may have a periphery surrounding a central portion and a plurality of apertures disposed through the periphery and the central portion. At least one of the apertures in the periphery may be positioned at an edge of the periphery, and may have an interior exposed at the edge. The sealing member and the base layer may define an enclosure. The first and the second wicking layer may each be disposed in the enclosure with the absorbent layer positioned between the first and the second wicking layer. Other dressings, systems, and methods are disclosed.

Abstract: Present invention is related to an ultrathin triboelectric nanogenerator having a positive assembly layer and a negative assembly layer electrically connected together. The positive assembly layer comprises a positive layer and a first electrode. The negative assembly layer comprises a negative layer and a second electrode. The said first electrode and the said second electrode are electrically connected with each other. The positive layer could be a foam layer with under 90 ?m thickness and less than 60 ?m pore size. The present invention firstly provides the ultrathin triboelectric nanogenerator with PU foam as the positive layer which could achieve better electrical performance compared to any conventional triboelectric nanogenerator.

Abstract: A negative pressure wound therapy device, kit, and method are provided for improved treatment of wounds on complex three-dimensional anatomies. The device includes a conformable manifold made of a porous and permeable material with a pattern of cuts designed to transform the manifold from a relaxed, planar state to a pliable three-dimensional state when extended along the lateral axis. The kit further may include a wound interface layer, an adhesive, breathable drape, and a pneumatic connection to a negative pressure wound therapy device. Finally, a method for treating wounds using reduced pressure and the presently disclosed kit is provided.

Abstract: Disclosed and described herein are systems and methods of energy generation from fabric electrochemistry. An electrical cell is created when electrodes (cathodes and anodes) are ‘printed’ on or otherwise embedded into fabrics to generate DC power when moistened by a conductive bodily liquid such as sweat, wound, fluid, etc. The latter acts, in turn, as the cell's electrolyte. A singular piece of fabric can be configured into multiple cells by dividing regions of the fabric with hydrophobic barriers and having at least one anode-cathode set in each region. Flexible inter-connections between the cells can be used to scale the generated power, per the application requirements.

Abstract: Disclosed embodiments relate to apparatuses and methods for wound treatment. In certain embodiments, a negative pressure wound therapy apparatus can include a spacer layer with an upper portion and a lower portion. The spacer layer can be configured to be wrapped around at least one edge of the absorbent layer with the upper portion of the spacer layer being above the absorbent layer and the lower portion of the spacer layer being below the absorbent layer. In some embodiments, a negative pressure wound therapy apparatus can include a first and second spacer layer and an absorbent layer. The first spacer layer can be positioned below the absorbent layer and the first spacer layer can have a perimeter larger than a perimeter of the absorbent layer. The second spacer layer can be positioned above the absorbent layer. The second spacer layer can have a perimeter larger than the perimeter of the absorbent layer.

Abstract: A wound dressing in the form of a bag enclosing fly maggots, having a porous wall made from plastic, the wall having a membrane made from an open cell polyurethane foam, the pore diameter of which is approximately 0.1 mm to approximately 1 mm.

Abstract: Provided are insulative apparatus and methods of forming insulative apparatus. As an example, a method of forming an insulative apparatus can include connecting a barrier material to a mold; injecting a polyurethane foam composition into the mold, wherein the polyurethane foam composition includes a polyol, an isocyanate, and supercritical carbon dioxide; curing the polyurethane foam composition to form a polyurethane foam and applying a vacuum to the mold to provide a pressure from 1 millibar to 500 millibar.

Abstract: A negative pressure wound closure system and methods for using such a system are described. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Some embodiments may utilize a stabilizing structure with dissolvable portions.

Abstract: The present invention relates to an adhesive patch. The adhesive patch includes a plurality of reliefs, each relief having a flat top face, and each micro channel groove defined between adjacent reliefs of the plurality of reliefs, wherein the plurality of reliefs and the micro channel groove are respectively formed on and defined the adhesive patch, and wherein a hydrogel layer is disposed on at least a portion of a bottom face of the micro channel groove and is contained in the groove. Therefore, the adhesive patch is well-adhered to a dry or wet adhered face.

Abstract: A body side member of an ostomy appliance having backing film forming a distal surface, the distal surface including one or more individual pockets containing a moldable material that can exit the pockets.

Abstract: An apparatus, system, and method for treating an incisional wound having incisional walls. The apparatus includes a conduit having a first end for receiving reduced pressure and a second end. The apparatus further includes a scaffold. The scaffold has opposing surfaces for positioning adjacent the incisional walls and is fluidly coupled to the second end of the conduit for receiving the reduced pressure. The scaffold is generally elongated in shape and has a thickness between the opposing surfaces that is sufficiently thin for positioning within the incisional wound. The apparatus further includes an internal manifold that has a primary flow channel extending generally longitudinally within the scaffold and between the opposing surfaces of the scaffold. The internal manifold is fluidly coupled to the second end of the conduit. The application of the reduced pressure through the scaffold and the internal manifold induces tissue apposition between the incisional walls.

Abstract: The present invention relates to a composite material, which is of particular use in wound treatment, and to a method for producing the same composite material. Said composite material comprises a hydrophilic polyurethane foam material comprising a first polyurethane polymer; a hydrophilic fiber material comprising a second polymer, wherein said second polymer is not a polyurethane polymer and wherein said fiber material is capable of absorbing and retaining a fluid. In the composite material according to the present invention, said first polymer is covalently bonded to said second polymer.

Abstract: Systems, methods and devices are provided for use in a negative pressure wound therapy system for healing a wound in a patient. Various aspects may include an ester-based material adapted to be directly applied to the wound, such as a smooth muscle fistula, without substantially damaging tissue in the wound during dressing changes. The ester-based material may have an affinity for the wound bed surface and/or wound fluid. In addition various aspects may include a device adapted to close the wound, such as a smooth muscle fistula.

Abstract: A cannulated tube protector comprising a main body, a first pair of securing members extending from the main body, a second pair of securing members extending from the main body, and a splinting member comprising a viewing door. The viewing door is structured to open thereby exposing a viewing aperture, defined as a doorway. The doorway extends from a first surface of the main body to an opposing second surface of the main body.

Abstract: A liner for an orthopedic or prosthetic device includes a core formed from a porous and compressible material, a first layer secured to the first side of the core and forming a first surface to the liner, and a second layer secured to the second side of the core and forming a second surface to the liner. The first and second layers may comprise different properties from one another and be formed from different materials including fabrics and polymeric materials. A polymeric film may be secured to the core or one of the layers to define at least part of a surface of the liner.

Abstract: Reduced-pressure medical dressings, systems, and methods involve a dressing with a first barrier layer that desolidifies when exposed to a fluid—typically a liquid—to form a treatment aperture in the first barrier that is used to deliver reduced pressure to a tissue site. The first barrier layer is formed from a desolidifying material. The system includes a drape covering a second surface of a manifold and a portion of the patient's epidermis to provide a substantially sealed space containing a manifold and the first barrier layer. Other systems, dressings, and methods are also disclosed.

Abstract: A dressing assembly for use with a reduced pressure treatment system, the dressing assembly develops a directed force under reduced pressure. The directed force may be a radial force or a closing force. The dressing assembly includes a shaped dressing bolster having a shaped extremity that is operable to evenly deliver the radial force and to distribute reduced pressure. Numerous shapes may be used for the shaped extremity. The dressing assembly may further include an over-drape to assist in creating a seal over the shaped dressing bolster and against a portion of a patient's epidermis.

Abstract: The present invention relates to a multilayered wound dressing particularly for wound treatment in the granulation and epithelization phase. The wound dressing comprises a) a first layer as a wound contact layer having a first side and a second side, and b) at least one second layer as an absorbent layer having a first side and a second side and comprising a hydrophilic polyurethane foam, wherein the polyurethane foam comprises a water fraction of at least 10% by weight of water.

Abstract: Some embodiments have a pump assembly mounted to or supported by a dressing for reduced pressure wound therapy. The dressing can have visual pressure, saturation, and/or temperature sensors to provide a visual indication of the level of pressure, saturation, and/or temperature within the dressing. Additionally, the pump assembly can have a pressure sensor in communication with the flow pathway through the pump, and at least one switch or button supported by the housing, the at least one switch or button being accessible to a user and being in communication with the controller. The pump assembly can have a controller supported within or by the housing, the controller being configured to control an operation of the pump. The pump can be configured to be sterilized following the assembly of the pump such that all of the components of the pump have been sterilized.

Abstract: Systems, apparatuses, and methods for closing an opening through a surface of a tissue site are described. The system includes a sealing member adapted to cover the opening to form a sealed space and a negative-pressure source adapted to be fluidly coupled to the sealed space to provide negative pressure to the sealed space. The system also includes a contracting layer adapted to be positioned adjacent the opening and formed from a material having a firmness factor and a plurality of holes extending through the contracting layer to form a void space. The holes have a perforation shape factor and a strut angle causing the plurality of holes to collapse in a direction substantially perpendicular to the opening. The contracting layer generates a closing force substantially parallel to the surface of the tissue site to close the opening in response to application of the negative pressure.

Abstract: A unique multi-functional emergency bandage stops bleeding by: (1) optimizing mechanical properties and preventing ischemia and/or necrosis while applying enough pressure to help stop bleeding, and (2) incorporating inorganic anti-bleeding nano-structures (embedded within a gauze and/or microbial cellulose) with almost infinite life-time. Additionally, pathogen passage through the bandage is prohibited (via an intermediate filter layer). Together with the overall anti-microbial character of the bandage, the unique multi-functional bandage offers all these vital features within a single design. The unique bandage can be applied by using a single hand and bandaging direction can be changed using a unique binding apparatus.

Abstract: An apparatus for cleansing wounds in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. microfiltration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.

Abstract: Super-soft foam materials, optionally for use as medical dressings, are provided. The pads are made of a foam prepared from NCO-terminated prepolymers in combination with an aqueous phase including fatty alcohols and alkyl polysaccharides. The foam may optionally contain at least one medicinal agent.

Abstract: The present invention pertains to antimicrobial compositions comprising inter alia at least one alkenyl- and/or alkynyl-substituted polysiloxane, at least one polysiloxane comprising silicon-bonded hydrogen atoms, and at least one hydrosilylation catalyst, as well as antimicrobial silicone gels, wound dressings, and methods of preparing the above.

Abstract: Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

Abstract: The present invention relates to an absorbent dressing comprising a breathable impermeable substrate (4) and an absorbent foam (2), which is particularly suitable for use in the care of chronic or acute wounds. The invention relates to a dressing comprising an absorbent foam (2) and a protective substrate (4) that is impermeable to fluids, but permeable to water vapor, said substrate being formed by assembling a film (4a) and an openwork reinforcement that is coated with an adhesive silicone gel (4b) without blocking the openings in the reinforcement. In addition, the dressing comprises a non-absorbent web (5) which is disposed between the absorbent foam (2) and the substrate (4), which adheres to the adhesive silicone gel coating on the reinforcement, and which adheres to the absorbent foam (2).

Abstract: A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.

Abstract: The present disclosure provides structures and/or gaskets for deposition between adjacent intestinal sections in an anastomosis procedure. The structure possesses at least an inner ring of a first material, and a middle ring of a second material. The first material and the second material include a wound treatment material consisting of at least one of an adhesive, a sealant and/or a medicament. The first material is different from the second material.

Abstract: A wound treatment system comprises a wound-treatment apparatus and a wound dressing coupled to the apparatus. The wound dressing includes a foam structure wound insert having pores with a greater cross-sectional area when viewed from a first direction and a smaller cross-sectional area when viewed from an orthogonal direction. Methods for making such wound inserts may include compressing foam structure material having pores with a substantially uniform cross-sectional area. Methods for treating a wound using a wound insert.

Abstract: An automatically self-adjusting variable permeability providing (AVPP) layer is provided over and in operative interaction with a wound site containing a wound to the integumentary system of a living creature such as the skin of a human patient. The AVPP layer has the capability of automatically changing in respective fluid permeability characteristics provided by respective subregions of the AVPP layer where the changes are in reaction to extant or changed conditions in corresponding micro-zones of the wound site. The automatic self-adjusting behaviors of the respective subregions of the AVPP layer can include providing a faster rate of vapor removal for micro-zones of the wound site that are too wet and providing a slower rate of vapor removal or essentially no vapor removal for micro-zones of the wound site that are too dry.

Abstract: An elongate adhesive article having a length substantially greater than a width includes a backing layer having an adhesive layer and a single weakened region formed of a removable strip of backing layer that is oriented substantially perpendicular to the article length. The removable strip of backing layer is at least partially defined by a pair of lines of weakness separated by a gap of between about 2 and about 15 mm. The elongate article may include an absorbent pad in the form of an adhesive bandage or sticking plaster. A method of using such an elongate article includes the steps of applying the article to the skin of a mammal, removing a predefined strip from the article; and removing the remainder of the article from the skin.

Abstract: Disclosed are methods for using open-celled polymeric foam wound dressings made from high internal phase emulsions (HIPEs). The wound dressings have a high capillary pressure and may reduce or obviate the need for treatments like negative pressure wound treatment (NPWT). Also disclosed are structures for HIPE foam wound dressings. The HIPE foam wound dressings typically include at least two layers of HIPE foam with different, but homogeneous, average cell sizes. The average cell sizes form a cell size gradient, with cell size typically decreasing from the front or face layer of foam toward the back layer of foam. The back layer of foam may be a collapsed layer, while the front layer or layers may be expanded. Compared with HIPE foams for other absorbent applications, the wound dressing foams may be higher in hydratable salts and higher in initial moisture levels.

Abstract: The invention refers to a disposable absorbent article such as a diaper, a pant or a sanitary napkin. The disposable absorbent article further comprises a structure which is able to elongate and simultaneously convert from an initial flat configuration into an erected configuration.

Abstract: The present invention relates to an adhesive wafer suitable for attachment to the skin or a wound, the wafer comprising a dressing sheet comprising a layer of skin-friendly adhesive, the adhesive layer being provided with a backing layer on the non-skin-facing surface thereof, and a flexible protection layer on the skin-facing surface of the adhesive layer, the protection layer protecting the adhesive layer before use of the wafer and the protection layer being attached to the adhesive layer in such a way that it is releasable and wherein the protection layer is in the form of a porous material.

Abstract: A wound dressing for covering a wound is formed of at least one absorbing member and a plurality of elongated activated carbon fibers. The at least one absorbing member is made of a foamed polymeric material and includes a plurality of pores. The activated carbon fibers are distributed in the at least one absorbing member and partially protrude into the pores. Each of the activated carbon fibers has a diameter of 2-15 ?m and a length of 40-1500 ?m. In light of the above, the tissue fluid leaking from the wound can be absorbed by the absorbing member to prevent the wound from soakage and the activated carbon fibers inside the absorbing member can emit far-infrared rays to promote the blood circulation around the wound for quickening healing of the wound.

Abstract: A vacuum bandage is provided for use with a wound having a wound surface. The bandage is connectable to a vacuum source and includes a wound dressing member having a wound contacting surface, a top surface, and a port configured for communication with the vacuum source. The wound dressing member further includes holes in the wound contacting surface configured for communication with the wound surface of the wound and a passageway between the port and each hole. The vacuum bandage further includes a pack adjacent to the top surface of the member. The pack may include an aperture positioned about the port.

Abstract: The invention provides a layered composition comprising: a first layer comprising a first material, wherein the first material comprises a gel material; a second layer comprising a second material, wherein the second material is harder is than the first material; and a third layer comprising a third material, wherein the third material has a lower tensile modulus than the second material, wherein the second layer is disposed between the first and third layers. The composition may be used in a wound dressing, in which preferably the first layer is in fluid flow communication with the wound.

Abstract: A reduced pressure treatment apparatus includes a charging chamber storing a first pressure less than an ambient pressure and a regulated chamber storing a second pressure less than the ambient pressure. The first pressure is less than the second pressure. A conduit provides fluid communication between the regulated chamber and the charging chamber. A regulator member is operably associated with the conduit to prevent fluid communication through the conduit when the second pressure is less than or equal to a desired therapy pressure and to allow fluid communication through the conduit when the second pressure exceeds the desired therapy pressure.

Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.

Abstract: In one aspect, a wound treatment system includes an inner layer comprising a foam material impregnated with a zinc oxide containing composition with or without calamine and/or ichthammol and in the presence or absence of antimicrobial agent (inorganic and/or organic). An optional outer layer comprises a short/long stretch compression bandage. In another aspect, a method of manufacturing the foam article impregnated with the zinc oxide containing composition is disclosed. In yet another aspect, a method of applying the wound treatment system to a patient's leg is disclosed. In still another aspect, a kit is provided including a foam layer impregnated with a zinc oxide containing composition; optionally, an elastic bandage component (e.g., long or short stretch elastic bandage); and, optionally, an outer stocking or sleeve, wherein the bandage system components are packaged together.

Abstract: A wound dressing comprising an open-cell foam substrate infused with an ion-containing composition in a water-dispersible carrier is provided. The composition includes citric acid or a salt thereof; salts of potassium, rubidium, and zinc ions; and a carrier comprising two or more polyol components, at least one polyol component being solid at 23 degrees C. A method of treating a wound with said wound dressing is also provided.

Abstract: A dental dressing to promote healing and relieve pain and swelling associated with exposed dental alveoli. The dressing includes a three-dimensional dressing matrix to absorb leaked fluid associated with one or more exposed alveoli, and a therapeutic member to provide substantially localized cold therapy to one or more exposed alveoli, the therapeutic member embedded substantially within the dressing matrix and shaped to substantially engage one or more exposed alveoli while fitting substantially between contiguous teeth. At least part of the dressing matrix substantially conforms to one or more exposed alveoli, thereby engaging the therapeutic member with one or more exposed alveoli.

Abstract: Embodiments disclosed herein are directed to the treatment of wounds using negative pressure. Some embodiments disclosed herein provide for a foam pad, which may be suitable for use in abdominal wound sites, and which may be sized in a dimensionally-independent manner. Additional embodiments provide for a wound contact layer, as well as a system for the treatment of abdominal wounds.

Abstract: The present invention relates to a wound packing material that comprises a porous material and is suitable for use in negative pressure wound therapy. The wound packing material comprises frangible regions defining a plurality of portions, the frangible regions allowing the portions to be selectively removed. The invention further relates to methods of manufacturing the wound packing material, and to methods of its use.

Abstract: Wound dressings and wound inserts comprising substantially dry reactive agents, methods of forming wound inserts comprising dry reactive agents, and wound-treatment methods.

Abstract: A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.

Abstract: In one aspect, a wound treatment system includes an inner layer comprising a foam material impregnated with a zinc oxide containing composition with or without calamine and/or ichthammol and in the presence or absence of antimicrobial agent (inorganic and/or organic). An optional outer layer comprises a short/long stretch compression bandage. In another aspect, a method of manufacturing the foam article impregnated with the zinc oxide containing composition is disclosed. In yet another aspect, a method of applying the wound treatment system to a patient's leg is disclosed. In still another aspect, a kit is provided including a foam layer impregnated with a zinc oxide containing composition; optionally, an elastic bandage component (e.g., long or short stretch elastic bandage); and, optionally, an outer stocking or sleeve, wherein the bandage system components are packaged together.

Abstract: An apparatus for stimulating healing of a wound, includes a porous pad adapted to contact a surface of the wound on an affected part of a body. An envelope for receiving the porous pad and the affected part of the body is provided, and the envelope includes a re-sealable opening that permits the wound to be inspected. A connector is fluidly connected to an interior of the envelope and to a source of negative pressure.