Abstract: The invention relates to a liquid-permeable primary dressing in the form of a supple thermoplastic section of material (1.4), comprising: a first smooth surface (4); a second surface (5) facing away from the smooth surface (4); and a plurality of three-dimensional perforations, whose walls extend from the first smooth surface (4) and end in an overhang with a free edge, thus making the second surface (5) rough to the touch. At least one of the free edges has an angled section that is approximately perpendicular to a perforation axis. In a preferred embodiment, the periphery (13) of the material section is smooth on both sides, i.e. on both the first and second surfaces (4; 5), the periphery (13) of the surface (5) that was at first rough being thermally smoothed.

Abstract: The invention relates to a medical plaster which is able to supply damaged skin and open wounds with an active compound which helps to accelerate wound healing and allows it to proceed better. The plaster has novel design features which enable, in particular, protein- or peptide-containing medicaments, such as, for example, erythro-poietin (EPO), to exert their wound-healing or wound-healing-promoting action by release of the active compound from the plaster without being significantly deactivated or metabolized in the process by substances occurring in the wound secretion.

Abstract: An abdominal wound dressing and methods of use are described that enable the application of negative pressure to the wound site in a healing manner while also limiting the formation of adhesions that would prevent the removal of the dressing. The dressing comprises a layer of porous foam material enclosed by sheets of elastomeric material punctuated by a number of appropriately placed holes. Multiple layers of porous foam may also be used. A suction tube connector is provided on an upper surface of a layer of foam for connection to a negative pressure source. At least one layer of foam is enclosed in elastomeric material and is placed in direct contact with the tissue within the open wound. Fluids are drawn by negative pressure through the holes positioned in the elastomeric envelope and through the foam.

Abstract: A medical access cover having a first layer and a second layer. The first layer comprises medically sterile material and defining lines which define a plurality of flaps that fold open to define a first wound access opening. The second layer defines a second wound access opening. The first layer and second layer are positioned suitable to align the first opening and the second opening.

Abstract: A multi-ply technical composite, usable in particular for making medical aids, garments and medical articles, includes at least two layers (2, 3), the first of which (2), in contact with the skin, is a cotton fabric (elasticised to a greater or lesser extent) or silk, or fabrics to which chitosan, silver or another antibacterial substance or active constituent is added, and the second, outer layer (3) is constituted by a semipermeable membrane, such as polyurethane between 5 and 80 microns thick, with considerable elasticity in order to ensure the user's comfort. Receptors rechargeable with active constituents are inserted into fabric (2) and protected by the polyurethane membrane.

Abstract: A wound contact device comprising a permeable material and a wound contact layer having voids extending through the contact layer to a depth in the permeable material. The wound contact layer can comprise a thin sheet or film forming a generally flat and smooth wound contact surface having essentially no discontinuities or gaps. The wound contact layer can comprise a thin sheet of highly calendered fabric forming a wound contact surface having a mean surface roughness in the range of about 0 microns to about 200 microns. In progressive wound healing, an embodiment of the wound contact device having the fabric contact surface is used in earlier healing stages and an embodiment of the wound contact device with film contact surface is used in later healing stages. The wound contact device is particularly useful in wound dressings for use in suction-assisted wound therapy.

Abstract: A wound dressing defining skin facing areas having different degrees of skin adherence. The dressing comprises a backing layer defining a center portion and a border portion surrounding the center portion. A carrier layer is secured to the border portion of the backing layer within the border portion and includes a first skin adherent facing layer. An absorbent core is connected to a surface of the backing layer within the center portion and a second skin adherent facing layer is disposed along a surface of the absorbent core. The first facing layer has greater skin adhesive properties than the second facing layer.

Abstract: A wound dressing including an absorbent core defining opposed proximal and distal surfaces. A perforated skin adherent facing layer is secured to a proximal surface of the absorbent core and a liquid impervious, vapor permeable backing layer is connected to a distal surface of the absorbent core. The backing layer defines at least one compliant element disassociated from the distal surface of the absorbent core and including at least one ridge extending outwardly relative to the distal surface of the absorbent core.

Abstract: Non-aerosol spray-on skin patch compositions as described comprising at least one substantially water insoluble film forming agent, at least one film plasticizer agent, at least one water soluble compound, and at least one organic solvent, the composition forming a flexible, porous and physiologically compatible skin patch when sprayed on to skin and allowed to dry. Also described are methods of improving wound healing by administering a physiologically active ingredient to a patient in need of such treatment.

Abstract: In various embodiments, a wound dressing includes a wound treatment composition including at least one absorbent or adsorbent compound contained within a sheath having an operatively inner and an operatively outer wall. A surface of the operatively inner wall of the wound dressing, that is to contact a wound in use, is a substantially smooth continuous surface conveniently of a plastic inner wall, selected for easy release from a wound. The inner wall is perforated to enable exudates or slough to pass therethrough. In some embodiments, a wound treatment composition includes an absorbent material, preferably silica, for adsorbing moisture on or around a wound and a collagen, conveniently gelatin.

Abstract: A method of forming a generally leak-proof peripherally sealed absorbent pad and a pad formed by such method are disclosed herein. Non-sealed layered pads are formed by assembling the following layers: (1) a sheet of liquid-impermeable material; (2) bibulous pads disposed on the sheet of liquid-impermeable material, the bibulous pads disposed relative to each other based on a predetermined spacing; (3) a liquid-permeable sheet disposed on top of the bibulous pads; and (4) a sheet of liquid-impermeable material having precut apertures disposed on the liquid-permeable sheet, the apertures sized and shaped to be framed by the pads and spaced relative to each other based on the predetermined spacing. The non-sealed layered pads are then sealed along a periphery of the precut apertures to the sheet of liquid-impermeable material to form a sheet of absorbent pads.

Abstract: A bandage for treatment of wounds having living fly larvae that produces a secretion and a sealed pouch including the living fly larvae. The sealed pouch completely encloses the fly larvae and prevents the fly larvae from touching the wound. The sealed the pouch is made of a fine-mesh net having a pore size that allows the passing of secretions produced by the fly larvae to reach the wound but prevents passage of the fly larvae enclosed in the pouch.

Abstract: The present invention relates to a medicinal product with a textile component such as a wound compress having a surface containing a multiplicity of openings arranged in at least two hole patterns. The diameter of one opening of one hole pattern deviates from the diameter of an opening of another hole pattern by about at least a factor of 5. Better wound healing is achieved by adapting the structural and mechanical characteristics of the medicinal product to the characteristics of the target tissue.

Abstract: A biocompatible substrate for use as a resorbable or non-resorbable implant, graft, prosthesis, etc., has an array of projections or pits of nanometer dimensions on a surface thereof, which resist attachment of cells. Typically the projections or pits are 10-250 nm in size and at spacings of 20-500 nm. The substrate may additionally have areas where cell adhesion is promoted.

Abstract: This invention relates to methods of promoting the healing of skin wounds, products for promoting the healing of skin wounds and processes for making such products. More particularly, this invention relates to layered absorbent dressings which absorb wound exudate in conjunction with additional products for assisting the healing of wounds at each stage of wound healing, as well as methods of using these dressings and methods of making these dressings.

Abstract: A bandage for treatment of wounds is described, including a wound overlay, which contains the secretion of fly larvae. The wound overlay can be a single pouch or may be subdivided into chambers, which enclose living fly larvae. It is likewise possible to soak or permeate the wound overlay with the secretion of fly larvae.

Abstract: The invention relates to a adhesive article comprising at least one backing layer with a first and second surface and a pressure sensitive adhesive layer adhered first surface of the backing layer in a pattern, wherein the pattern of the adhesive layer has an adhesive free area of less than about 25% and wherein the adhesive article has a water vapor transmission rate of greater than about 2000 g/m2/24 hour. The invention also relates to a method of forming an adhesive article comprising (a) providing a release liner, (b) applying pressure sensitive adhesive in a pattern wherein the free adhesive area is less than 25%, and (c) applying a backing layer to the pressure sensitive adhesive. The present invention provides pattern coated adhesive bandages that strongly adhere to human skin while permitting water vapor transmission there through. Accordingly the present invention also provides methods of facilitating the healing of wounds using the pattern coated adhesive bandage.

Abstract: The present invention provides processes by which a polymeric hydrogel can be securely adhered to a substrate to form a hydrogel laminate with greatly improved delamination resistance. The laminate is formed by casting onto a polymeric adhesive-coated substrate an aqueous solution of hydrophilic polymer, then exposing this composite to ionizing radiation which cross-links the hydrophilic polymer to form a hydrogel and also induces copolymerization of the hydrophilic polymer and the adhesive polymer.

Abstract: An absorbent article and a method for manufacturing an absorbent article are disclosed. The absorbent article is made from an inner core absorbent material, which is surrounded by an apertured film. The absorbent material is selected from rayon, cotton, wood pulp, polyester, polyamide, polyolefin, copolymers thereof, and combinations thereof. The absorbent article has a bottom layer, which is made of an apertured film oriented such that protuberances face the inside of the absorbent article. The absorbent article also has a top layer, which is made of an apertured film oriented such that the protuberances face the outside of the absorbent article. The absorbent article may be useful in various applications including sanitary protection and bandages.

Abstract: An absorbent article and a method for manufacturing an absorbent article are disclosed. The absorbent article is made from an inner core absorbent material, which is surrounded by an apertured film. The absorbent material is selected from rayon, cotton, wood pulp, polyester, polyamide, polyolefin, copolymers thereof, and combinations thereof. The absorbent article has a bottom layer, which is made of an apertured film oriented such that protuberances face the inside of the absorbent article. The absorbent article also has a top layer, which is made of an apertured film oriented such that the protuberances face the outside of the absorbent article. The absorbent article may be useful in various applications including sanitary protection and bandages.

Abstract: This invention is an anti-proliferative drug placed onto or within a sterile sheet or mesh that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This mesh or gauze onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL™ absorbable hemostat gauze-like sheet with an anti-proliferative drug such as Rapamycin or Taxol, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions. Another embodiment of this invention is an anti-proliferative drug attached to a bandage that is placed onto a cut in the skin to decrease scar tissue formation.

Abstract: Protective bandages in accordance with this invention include an anchoring strip having a protective layer on a lower surface thereof for overlying a desired area on a person's skin. Force-transmission-impeding means is provided on the side of the anchoring strip opposed to the side including the protective layer. The force-transmission-impeding means includes a top sheet adhered adjacent peripheral edges thereof to an upper surface of the anchoring strip to define an internal compartment between the anchoring strip and the top sheet. A compressive cushioning member is provided within the internal compartment for absorbing compressive forces, and low friction, relatively movable confronting surfaces are provided within the internal compartment spaced from the upper surface of the anchoring strip to absorb shear forces imposed upon the bandage.

Abstract: A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m2 applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40° C.) of at least 1000 g/m2/day, preferably at least 6000 g/m2/day.

Abstract: A bandage for treatment of wounds is described, including a wound overlay, which contains the secretion of fly larvae. The wound overlay can be a single pouch or may be subdivided into chambers, which enclose living fly larvae. It is likewise possible to soak or permeate the wound overlay with the secretion of fly larvae.

Abstract: A non-stretching wound dressing is provided for use with a patient. The wound dressing includes a cover sheet having top and bottom sides, a thin film sheet formed on the bottom side of the cover sheet, the film sheet having first and second ends and an adhesive side, and a carrier sheet in adjacent contact with the adhesive side of the thin film sheet. The dressing also includes a first gripping tab attached to one end of the thin film sheet and disposed between the film sheet and the carrier sheet for separating the carrier sheet from the film sheet with the cover sheet remaining affixed to the film sheet. A second gripping tab is attached to the top side of the cover sheet and at one end of the cover sheet so that pulling on the second gripping tab releases the cover sheet from the film sheet with the film sheet remaining in place on the patient.

Abstract: The invention disclosed herein is a medical pressure dressing. The dressing includes a frame for affixing to skin surrounding the skin treatment site and a strap for covering the frame and wound. The frame has a channel extending therethrough providing an orifice over the skin treatment site. The strap includes, or else includes means for attachment to, a plunger that is shaped for being received downwardly through the channel and against the wound when the strap is extended across the frame. The present application further discloses a process for treating a wound that includes a tissue covered by a skin treatment site. The process includes reducing the elasticity of the skin treatment site by affixing a frame having an elasticity less than the elasticity of the skin treatment site around the skin treatment site, and performing an elasticity-sensitive procedure on the wound. Examples of elasticity-sensitive procedures include pushing, cutting, puncturing, rubbing, and such.

Abstract: This invention relates to a composition containing a hydrophobic solvent, a network polymer and a flow control agent which is useful in healing wounds. The composition of this invention may be applied directly to a wound to create a structured occlusive dressing. The dressings of this invention do not migrate, but maintain their integrity at skin temperature, and encourage the creation of a moist wound environment while protecting the wound in order to accelerate healing.

Abstract: A biodegradable, flexible wound covering based on fibrin and a process for its preparation are described, in which a fibrinogen solution is subjected to a single-stage or multistage dialysis, then a flexible fibrin web is formed by action of an aqueous thrombin solution on the fibrinogen solution and this is subsequently subjected to freeze-drying.

Abstract: A film dressing, in particular for the human or animal body, consisting of a flexible, conformable polymer film which is detachably bonded on the side facing away from the skin to a supporting sheet and is provided on the side facing the skin with a pressure sensitive adhesive layer which is in turn provided with an at least two-part protecting layer which can be pulled off, is characterized in that the protecting layer has hinge-like connections at two opposite edges to the supporting sheet.

Abstract: The present invention provides a wound dressing comprising a mixture of textile fibres and gel forming fibres wherein the dressing is a knitted fabric comprising support yarn and in-laid yarn, the support yarn being substantially free of gel-forming fibres.

Abstract: The dressing system of the present invention provides, in one aspect, a composite dressing that allows a wound to be dressed in one easy step and redressed without disturbing the wound. The composite dressing comprises a contact component having a bottom side facing a wound, and a top side. A dressing component is releasably attached to the top side of the contact component such that the dressing component can be readily separated from the contact component if pulled relative to the contact component. The contact component can remain on the wound to prevent disturbance, and another composite dressing or dressing component can be applied to the contact component.

Abstract: A porous sheet suitable for use in first-aid sticking plasters, poultices, etc. as the substrate is described. The porous sheet comprises a thermoplastic polymer, and an arbitrary cross section of the porous sheet has a polymer packing of 30 to 90% and contains 2 to 100 polymer sections having a sectional area of 0.001 mm2 or less per millimeter along the surface of the porous sheet. At least one surface of the porous sheet is in net-work structure (a) formed by fiber-like bodies which are integrally bonded to each other at intersections by fusion of polymer constituting the fiber-like bodies and/or net-work structure (b) formed by fiber-like protrusions. With such structures, the porous sheet has a moderate air permeability, and is good in soft texture and highly resistant to fluff formation by rubbing.

Abstract: A process and device for improved healing of large avulsed or burned tissue which prevents excessive cicatricial, keloid or fibromatoid formation, reduces fluid loss, and increases protection from infection by employing an elastomer matrix; i.e., a thin sheet of elastomer with a plurality of fenestrations, placed on the wound and a bath of oil to cover the matrix. The oil bath is provided by a flexible sealed capsule of thin silicone elastomer, preferably filled with soybean oil that percolates through the walls of the capsule. Enhanced granulation tissue formation is promoted by encapsulation of the wound with the matrix. Granulation tissue engulfs the matrix while the matrix integrity and elastic rigidity acts to reduce scarring. The barrier of the sterile soybean oil bath and the barrier of the elastomer matrix improve antisepsis and acts to reduce loss of body fluids.

Abstract: An improved wound dressing is provided which comprises a backing layer bearing a reference marking, a hydrocolloid layer and a release layer. The hydrocolloid swells in use. This swelling can be seen or felt through the backing layer. When the swelling extends to or beyond the reference marking, the dressing should be changed to prevent leaking. Thus, the dressing can be left in place for as long as possible, but not so long as to damage the underlying skin.

Abstract: A wound dressing (1) comprising a layer of absorbent foam material (2) which includes a pattern of holes (4). The holes open out on that side of the foam material which lies proximal to the wearer's skin when the dressing (1) is worn, and the layer of foam material is coated with a layer (3) of skin-adhering hydrophobic gel, wherein those end parts of the walls of the holes in the foam material that lie proximal to the wearer's skin when the dressing is worn are gel coated. A method of producing such a dressing is also disclosed.

Abstract: The present invention provides an adhesive article that includes a backing substrate and a discontinuous adhesive layer disposed thereon, wherein the backing substrate comprises a fibrous web and absorbent particulate material, and further wherein the article has an initial wet skin adhesion of at least 20 g/2.5 cm (0.08 N/cm).

Abstract: An absorbent pack for absorbing body fluids is provided. The absorbent pack includes an absorbent member and an enclosure assembly that surrounds the absorbent member. Apertures are formed in the enclosure member to permit body fluid to pass therethrough and be absorbed by the absorbent member. The enclosure assembly is made of a material that avoids unwanted adherence between the absorbent pack and a patient's skin or other body tissue. The enclosure assembly has a size to allow the absorbent member to expand without being impeded when it absorbs body fluid. A retention member can be joined to an anterior end of the absorbent member to assist in the removal of the absorbent pack from a body cavity. A cap member can be joined to the anterior end in order to avoid the possibility of separation of the anterior end from remaining portions of the absorbent member when the absorbent pack is removed from a body cavity.

Abstract: There is provided a novel wound dressing material which has biocompatibility and infection controllability as essential properties required for such a material, especially excellent flexibility and water absorption properties, thereby accelerating smooth regeneration of a skin defect without stripping off the regenerating skin while removing the material from the skin. A healing agent is added to the wound dressing material which comprises an amorphous film of a crystallinity below 10% and contains fibroin and sericin as a main component.

Abstract: A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m2 applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40° C.) of at least 1000 g/m2/day, preferably at least 6000 g/m2/day.

Abstract: A therapeutic mat for application to a person includes a relatively elastic substrate of a predetermined size, a hydrogel substance connected to the elastic substrate, and a plurality of microcrystals dispersed throughout the hydrogel substance. The therapeutic mat may further include retaining straps connectable to the elastic substrate and of a size and configuration to extend about the part of the body for supporting the therapeutic mat in a relatively fixed position.

Abstract: A bandage that has a securing portion made of any adhesive material connected to a domed portion that is made of any rigid material that is pleated in the middle that provides shielding to protected areas from physical trauma that also flexes and allows air to flow to and from the protected area.

Abstract: A conformable wound dressing is prepared by producing a sub-confluent layer of cultured mammalian cells such as epithelial cells anchored to a surface of a synthetic polymeric film which is hydrophobic, non-inhibitory to cell growth and non-cytotoxic. The polymer may be ethylene-vinyl acetate copolymer or a blend of ethylene-vinyl acetate copolymer and polystyrene, and is preferably subjected to corona discharge to improve cell attachment. The polymeric film may be sterilized with ethylene oxide or by gamma-irradiation. Preferably, the polymeric film is a continuous film containing apertures formed by perforation before or after cell culture to provide an apertured wound dressing. In a preferred embodiment, a laminate is formed containing a sub-confluent layer of mammalian cells anchored to a surface of a continuous film of synthetic polymer having a plurality of thin and thick portions cast on and supported by a carrier layer having a plurality of raised portions.

Abstract: The dressing system of the present invention provides, in one aspect, a composite dressing that allows a wound to be dressed in one easy step and redressed without disturbing the wound. The composite dressing comprises a contact component having a bottom side facing a wound, and a top side. A dressing component is releasably attached to the top side of the contact component such that the dressing component can be readily separated from the contact component if pulled relative to the contact component. The contact component can remain on the wound to prevent disturbance, and another composite dressing or dressing component can be applied to the contact component.

Abstract: A wound dressing is disclosed in which a pressure-sensitive adhesive layer, preferably of a soft, pliant adhesive composition having one or more hydrocolloids dispersed therein, is backed by an elastomeric film and has its opposite (bodyside) surface covered by a removable primary release sheet and a release strip, with at least a portion of the release strip being interposed between the adhesive layer and the primary release sheet along one side edge of the dressing. The primary release sheet and the release strip have superposed or overlapping tab portions that project outwardly beyond a side edge portion of the dressing. In a preferred embodiment, the adhesive and backing layers are translucent and the release strip is visible therethrough by reason of sharp color or tonal contrast in relation to the primary release sheet.

Abstract: Device for protecting large wounds, such as surgical incisions, from the environment. The device contains a semi-rigid, flexible plate with attaching means which direct environmental pressures away from the wound.

Abstract: The present invention relates to a multi-layered wound dressing particularly for use as a dressing on highly exudating wounds.

Abstract: A bandage in the form of a reinforced silicone gel sheet for the treatment of scar tissue is disclosed. The bandage consists of a first layer of silicone adapted to adhere to the skin, a second layer of polyester mesh fabric with a plurality of holes therethrough, which contacts the first layer, and a third layer of silicone. The third layer acts as a sealant and an adhesive when applied to the mesh fabric by projecting through the holes in the mesh fabric to seal the second layer and to laminate the second layer between the first layer and the third layer. The sealant effect of the third layer provides a non-adherent surface which enables the bandage to be worn underneath clothing. A method of manufacture is also disclosed.

Abstract: A bilayer laminated medical dressing having a thermally expandable passage is provided. The medical dressing achieves gas permeability as a function of temperature by cutting a star-shaped hole through the dressing when the dressing is flat and relaxed. On warming, the leaves between the radial cuts of the star-shaped hole curl and increase the hole size. Such a material is useful as a medical dressing.

Abstract: A wound dressing comprising an absorbent layer (5) and absorbent layer retaining means wherein the absorbent layer retaining means comprises an adhesive annular foam flange (2).

Abstract: A conformable wound dressing is prepared by producing a sub-confluent layer of cultured mammalian cells such as epithelial cells anchored to a surface of a synthetic polymeric film which is hydrophobic, non-inhibitory to cell growth and non-cytotoxic. The polymer may be ethylene-vinyl acetate copolymer or a blend of ethylene-vinyl acetate copolymer and polystyrene, and is preferably subjected to corona discharge to improve cell attachment. The polymeric film may be sterilized with ethylene oxide or by gamma-irradiation. Preferably, the polymeric film is a continuous film containing apertures formed by perforation before or after cell culture to provide an apertured wound dressing. In a preferred embodiment, a laminate is formed containing a sub-confluent layer of mammalian cells anchored to a surface of a continuous film of synthetic polymer having a plurality of thin and thick portions cast on and supported by a carrier layer having a plurality of raised portions.