Polysaccharide Patents (Class 602/49)
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Patent number: 12157875Abstract: A scaffolding material for culturing a cell, the scaffolding material for culturing a cell containing a synthetic resin, and having a nitrogen content of the synthetic resin of 0.1% by mass or more and 10% by mass or less. According to the scaffolding material for cell culture, the scaffolding material can have suitable hydrophilicity and strength, high fixation of cells after seeding, and highly efficient cell proliferation.Type: GrantFiled: July 2, 2020Date of Patent: December 3, 2024Assignee: SEKISUI CHEMICAL CO., LTD.Inventors: Satoshi Haneda, Yuriko Manabe, Ryoma Ishii, Hiroki Iguchi, Hiroshi Yamauchi, Takahiro Omura
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Patent number: 11898274Abstract: A hydrogel-forming multicomponent fiber includes: at least one first fiber component; and at least one second fiber component. The first and the second fiber components are selected independently of one another from a group consisting of polysaccharides and/or polysaccharide derivatives. The first fiber component is produced from a polysaccharide and/or a polysaccharide derivative having a water solubility of more than 50% by weight. The multicomponent fiber has a water solubility of less than 15% by weight.Type: GrantFiled: June 21, 2018Date of Patent: February 13, 2024Assignee: CARL FREUDENBERG KGInventors: Birgit Kosan, Michael Mooz, Frank Meister
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Patent number: 11564673Abstract: The present disclosure relates to a gastrointestinal delivery device of a dressing, where the delivery device is capable of fitting through a narrow channel before expanding and applying the dressing. The gastrointestinal delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.Type: GrantFiled: December 28, 2018Date of Patent: January 31, 2023Assignees: Tricol Biomedical, Inc., Oregon Health & Science UniversityInventors: Kenneth E. Perry, Kenneth P. Perry, Hua Xie, Brintha Enestvedt, Simon J. McCarthy
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Patent number: 10653783Abstract: Methods of producing microporous zwitterionic cryogels are described, wherein the cryogels are useful for sustaining release of therapeutic agents. The disclosed cryogels overcome several limitations associated with existing compositions, for example the disclosed cryogels have high loading efficiencies and a sustained release profile with minimal burst of up to 4 months or more. The characteristics of the disclosed cryogels can be varied by altering monomer (e.g. zwitterion) and crosslinker selection. The amount of monomer contained in the hydrogel may also be varied to aid in controlling the cryogel's chemistry.Type: GrantFiled: November 9, 2017Date of Patent: May 19, 2020Inventors: Melissa D. Krebs, Gulsu Sener Yildirim
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Patent number: 10549015Abstract: The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps: a°) a first solution, comprising an oxidized collagen is prepared, b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7 %, by weight, with respect to the total weight of the solution, c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid, d) a diluted solution is prepared by adding water to solution of c), e) a first layer of solution obtained in c) is casted on an inert support, f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify, g) the gelified first and second layers are dried to obtain a film.Type: GrantFiled: September 23, 2015Date of Patent: February 4, 2020Assignee: Sofradim ProductionInventors: Nicolas Prost, Delphine Petit, Xavier Bourges
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Publication number: 20150079196Abstract: A wound dressing makes use of polysaccharides, including the formation of a range of variable viscosity mixtures that use a solid polysaccharide such as medical grade cane sugar and a liquid polysaccharide such as honey, both of which have inherent beneficial properties for wound healing. The mixture is applied to an absorbent surface that is designed to absorb the mixed polysaccharide only partially.Type: ApplicationFiled: September 19, 2013Publication date: March 19, 2015Applicant: MEDLINE INDUSTRIES, INC.Inventors: Debashish Chakravarthy, Andrew J. Ford
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Patent number: 8933290Abstract: A mesh implant is disclosed which may be utilized for treating urinary incontinence, hernias, uterovaginal prolapses and other related injuries.Type: GrantFiled: June 26, 2007Date of Patent: January 13, 2015Assignee: Sofradim Production SASInventors: Olivier Lefranc, Philippe Gravagna, Yves Bayon, Michel Therin
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Publication number: 20140171848Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.Type: ApplicationFiled: February 20, 2014Publication date: June 19, 2014Applicant: Z-Medica, LLCInventors: Raymond J. Huey, Denny Lo, Daniel J. Burns, Giacomo Basadonna, Francis X. Hursey
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Patent number: 8653319Abstract: A hydratable gel-forming polymer may be sterilized by chilling the polymer below ambient temperature and sterilizing the chilled polymer using ionizing radiation (e.g., E-Beam radiation). Doing so may reduce the degradation in physical properties caused by ionizing radiation sterilization of the polymer while at ambient temperature, and may preserve or retain desired hydration or gel-forming characteristics.Type: GrantFiled: April 23, 2009Date of Patent: February 18, 2014Assignee: Medtronic, Inc.Inventors: Drew Powell Amery, Matthew F. Myntti
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Publication number: 20130296760Abstract: A wound dressing including at least one layer made of microbially produced cellulose formed into a biocellulose layer, wherein the wound dressing is configured to adsorb bacteria and wherein the thickness of the bio-cellulose layer is between 0.08 and 1.5 mm, as well as a method for producing such a wound dressing.Type: ApplicationFiled: November 1, 2011Publication date: November 7, 2013Inventors: Ralf Ramminger, Hugh Andrews, Patrick Schütz
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Patent number: 8575132Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.Type: GrantFiled: January 11, 2013Date of Patent: November 5, 2013Inventor: Xin Ji
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Publication number: 20130079695Abstract: A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.Type: ApplicationFiled: November 20, 2012Publication date: March 28, 2013Applicant: Z-Medica, LLCInventor: Z-Medica, LLC
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Patent number: 8313474Abstract: An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.Type: GrantFiled: December 17, 2007Date of Patent: November 20, 2012Assignee: HemCon Medical Technologies, Inc.Inventors: Todd D. Campbell, William P. Wiesmann, Simon J. McCarthy
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Patent number: 8283515Abstract: An absorbent article such as a diaper, pant diaper, adult incontinence guard, sanitary napkin and the like contains a skin conditioning agent in at least a portion of the article so as to be transferable to the skin of the wearer. The skin conditioning agent is contained in a hydrogel foam material (9; 19; 20) intended to be applied in skin contact with the wearer, either directly or indirectly via a liquid permeable material (2).Type: GrantFiled: May 2, 2003Date of Patent: October 9, 2012Assignee: SCA Hygiene Products ABInventors: Marie-Louise Lagerstedt-Eidrup, Anne Farbrot, Bo Runeman
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Publication number: 20120215149Abstract: A tissue dressing material for being applied in contact with a tissue of a patient. The tissue dressing material's main component is deacetylated native chitosan. Moreover, a liquid tissue dressing material for being applied in contact with a tissue of a patient, the tissue dressing material being an aqueous mixture. The main component of the constituent(s) of the mixture other than water is deacetylated native chitosan.Type: ApplicationFiled: September 1, 2009Publication date: August 23, 2012Applicant: Medovent GmbHInventors: Rivelino Montenegro, Thomas Freier
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Patent number: 8152750Abstract: The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.Type: GrantFiled: September 13, 2004Date of Patent: April 10, 2012Assignee: Marine Polymer Technologies, Inc.Inventors: John N. Vournakis, Sergio Finkielsztein
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Patent number: 7815932Abstract: To provide a patch containing fentanyl for mucous membrane of the oral cavity (oral transmucosal fentanyl), which rapidly increases the serum concentration of the drug, is easy in handling and is superior in safety. The patch can be prepared by laminating on one side of a drug layer which contains fentanyl or its salt as an active ingredient, methyl vinyl ether-maleic anhydride copolymer as an adhesive, and at least one substance selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose as a thickener, a support layer hardly soluble or insoluble in water, and a backing in this order.Type: GrantFiled: June 1, 2004Date of Patent: October 19, 2010Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Katsumi Ihara, Mitsuhiro Nagata, Sayoko Inazuki
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Patent number: 7794450Abstract: An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.Type: GrantFiled: October 28, 2004Date of Patent: September 14, 2010Assignee: Smith & Nephew PLCInventors: Patrick Lewis Blott, Bryan Greener, Edward Yerbury Hartwell, Julian Lee-Webb, Derek Nicolini, Clare Green, Robin Paul Martin
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Patent number: 7780979Abstract: This invention involves fabric-supported chitosan modified temperature responsive PNIPAAm/PU hydrogel and the use thereof in preparation of facial mask. The merit of this invention is the hydrogel formed can reversibly swell and deswell near body temperature; the incorporation of PU can suppress the syneresis of PNIPAAm at an elevated temperature; Grafting of PNIPAAm and PU onto the surface of cellulose fabrics can enhance the mechanical strength of hydrogel; Coupling of chitosan to the surface of hydrogel can not only improve the handle and skin affinity, but also render the facial mask antibacterial; The hydrogel is capable of loading a variety of nutrients (or other functional components), which can release at body temperature; the hydrogel facial mask can be reusable with repeated rinsing.Type: GrantFiled: January 27, 2006Date of Patent: August 24, 2010Assignee: The Hong Kong Polytechnic UniversityInventors: Jinlian Hu, Wenguang Liu, Baohua Liu
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Patent number: 7758939Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.Type: GrantFiled: January 10, 2005Date of Patent: July 20, 2010Inventors: Kevin S. Marchitto, Stephen T. Flock
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Patent number: 7753894Abstract: An apparatus for cleansing wounds with means for stressing the wound bed and optionally tissue surrounding the wound, in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The means for stressing the wound bed and optionally tissue surrounding the wound promotes wound healing. The dressing and a method of treatment using the apparatus.Type: GrantFiled: December 17, 2007Date of Patent: July 13, 2010Assignee: Smith & Nephew PLCInventors: Patrick Lewis Blott, Edward Yerbury Hartwell, Derek Nicolini, Clare Green, Robin Martin, Bryan Greener, Julian Lee-Webb
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Patent number: 7709556Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.Type: GrantFiled: October 9, 2003Date of Patent: May 4, 2010Assignee: Poly-Med, Inc.Inventor: Shalaby W. Shalaby
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Patent number: 7652190Abstract: An integrated wound dressing system and method including a bandage and a self-contained receptacle that stores treatment material for the care and treatment of wounds. The treatment material is easily accessible and can be removed from the receptacle through an exit. The treatment material can then be used to control bleeding and/or clean the wound before dressing. The bandage may include a layer of plastic that acts as an occlusion barrier to reduce heat loss and maintain moisture levels at the wound site. The occlusion barrier also acts to prevent the passage of air into or out of the wound site. The bandage also includes fasteners that act to prevent unintentional unraveling and to secure the bandage during final packaging. These fasteners help facilitate the wrapping of amputations, stumps, and extremities. The integrated wound dressing system provides an all-in-one system for treating and dressing wounds and reduces the time required to do so.Type: GrantFiled: April 18, 2007Date of Patent: January 26, 2010Assignee: Tactical Medical Solution, Inc.Inventor: Ross A. Johnson
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Publication number: 20080287907Abstract: Systems and methods provide intraluminal delivery of a bandage structure within a body lumen or hollow body organ.Type: ApplicationFiled: December 20, 2007Publication date: November 20, 2008Inventors: Kenton Gregory, Amanda Dayton
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Publication number: 20080269659Abstract: Some embodiments of the invention provide an apparatus for achieving hemostasis in a puncture tract in a patient (e.g., a human or animal). Such a tract might have been created during a medical procedure or operation. Alternatively, the tract might be a result of a traumatic injury (e.g., injury that occurred outside of a hospital) that created a traumatic wound, such as a bullet wound, shrapnel or knife puncture. The puncture typically extends from the epidermis to the vasculature and/or internal organs in a living organism. In some embodiments, the apparatus includes (1) a bandage for inserting at least partially into a puncture tract to achieve hemostasis, and (2) a strap for maintaining the bandage on a part of a patient (e.g., a part of a human or animal such as appendage, torso, extremity, etc.). The strap maintains the bandage within the puncture tract at a particular pressure in some embodiments. The bandage and strap are removed from the patient after a time period (e.g.Type: ApplicationFiled: September 26, 2007Publication date: October 30, 2008Inventors: Patrick J. Bergin, Jeffrey P. Wensel
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Patent number: 7229689Abstract: This invention relates to polysaccharide fibres having water absorption properties characterised by the incorporation within the fibres of at least one substance having anti-microbial properties, and to wound dressings formed from said fibres. The polysaccharide fibres are preferably formed from alginate or alginate containing additional polysaccharide materials to give additional absorbency (such as, for example, sodium carboymethyl cellulose). The fibres preferably contain a silver compound as an antimicrobial agent.Type: GrantFiled: November 5, 2001Date of Patent: June 12, 2007Assignee: SSL InternationalInventors: Yimin Qin, Melanie Rachel Groocock
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Patent number: 7141714Abstract: Wound care device comprising chitosan, said chitosan being capable of absorbing liquid to form a swollen, coherent gel, and said chitosan being in the form of fibres having been modified by treatment with acid in a solvent which is not able to dissolve the chitosan fibres and by treatment with heat.Type: GrantFiled: October 29, 2004Date of Patent: November 28, 2006Assignee: Coloplast A/SInventor: Brian Nielsen
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Patent number: 7094418Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.Type: GrantFiled: November 17, 2004Date of Patent: August 22, 2006Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, David L. Clapper
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Patent number: 7019191Abstract: The present invention is directed to methods of making wound dressings that include the steps of contacting a fabric substrate having properties effective for use as a hemostat and containing fibers prepared from a biocompatible polymer, with a solution of a water-soluble or water-swellable biocompatible polymer under conditions effective to distribute the polymer solution substantially homogenously on and through the fabric substrate, transferring the fabric substrate to a lyophilization unit under conditions effective to maintain the homogeneous distribution on and throughout the substrate, and lyophilizing the fabric having the polymer solution distributed on and there through.Type: GrantFiled: March 25, 2003Date of Patent: March 28, 2006Assignee: Ethicon, Inc.Inventors: Dwayne Lee Looney, John Crilley, Jian Xin Guo, Guanghui Zhang, Sanyog Manohar Pendharkar
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Patent number: 7011093Abstract: Nasal dilators and strips, methods of their manufacture, and methods for improving the breathing of individuals are provided. The strips and dilators include an elongated substrate, with or without a dilating component or portion, having top and bottom surfaces and a pressure-sensitive adhesive disposed on the bottom surface. The dilator is designed to provide a gentle expanding force to the nasal wall tissue when the dilator is adhesively attached to the nose. This invention further includes a cosmetic fragrance, an aromatic medication and/or transdermal medication disposed on the strips or dilators. In order to improve the shelf-life and in-use olfactory effectiveness of such products, fragrance delivery mechanisms are used. Separation of volatile oils and adhesives are also provided to minimize adhesive residue.Type: GrantFiled: April 21, 2003Date of Patent: March 14, 2006Assignee: CNS, Inc.Inventors: Milton W. Anderson, Nobuya Hashizume, Peter J. Cronk, Kristen Cronk
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Patent number: 6998509Abstract: Wound care device comprising chitosan, said chitosan being capable of absorbing liquid to form a swollen, coherent gel, and said chitosan being in the form of fibers having been modified by treatment with acid in a solvent which is not able to dissolve the chitosan fibers and by treatment with heat.Type: GrantFiled: October 4, 2000Date of Patent: February 14, 2006Assignee: Coloplast A/SInventor: Brian Nielsen
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Patent number: 6756518Abstract: A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-&bgr; activity is also provided.Type: GrantFiled: January 25, 2002Date of Patent: June 29, 2004Assignee: United States Surgical CorporationInventors: Elliott A. Gruskin, Christofer T. Chistoforou
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Patent number: 6599523Abstract: The invention provides wound dressings and methods of their use, especially for the treatment of chronic, non-healing wounds. The wound dressings are composed of a support matrix, such as cotton cellulose, and an active agent associated with the support matrix. The active agent may be a protease inhibitor or a protease sequestrant, in particular an inhibitor or sequestrant of a neutrophil-derived cationic protease such as elastase.Type: GrantFiled: February 28, 2001Date of Patent: July 29, 2003Assignees: Virginia Commonwealth University, The United States of America as represented by the Department of AgricultureInventors: Kelman I. Cohen, Robert F. Diegelmann, Dorne Yager, Judson Vincent Edwards
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Patent number: 6541678Abstract: The present invention discloses an immunostimulating agent that may be applied to various surgical devices to promote rapid healing and the ready acceptance and integration of the surgical devices with the body tissues at the surgical site.Type: GrantFiled: March 21, 2001Date of Patent: April 1, 2003Assignee: Brennen Medical, Inc.Inventor: Barbara Klein
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Publication number: 20020161440Abstract: Disclosed are a dermal scaffold comprising alkaline pre-treated free amine-containing chitosan matrix, alkaline pre-treated free amine-containing chitosan and alkaline pre-treated collagen mixed matrix, or alkaline pre-treated free amine-containing chitosan and alkaline pre-treated collagen mixed matrix containing chitosan fabrics, which has excellent wound healing effect by constituting microenvironments suitable for migration and proliferation of fibroblasts and vascular cells surrounding the wound to be extremely useful as wound healing dressings, and a bioartificial dermis comprising the dermal scaffold and human fibroblasts, particularly useful for healing broad wound sites such as burns.Type: ApplicationFiled: April 25, 2002Publication date: October 31, 2002Inventors: Young-Sook Son, Yong-Ha Youn, Seok-Il Hong, Seung-Hoon Lee, Yong-Jae Gin, Kyu-Bo Han, Chun-Ho Kim
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Patent number: 6410044Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.Type: GrantFiled: May 16, 2000Date of Patent: June 25, 2002Assignee: Surmodics, Inc.Inventors: Stephen J. Chudzik, David L. Clapper
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Publication number: 20020064551Abstract: Sequestrants and inhibitors of protease are applied to the wound site through the use of wound dressing based carrier systems to which they may be optionally ionically or covalently bound for the purpose of the initiation or enhancement of healing associated with chronic non-healing wounds.Type: ApplicationFiled: December 13, 2001Publication date: May 30, 2002Inventors: J. Vincent Edwards, Robert F. Diegelmann, I. Kelman Cohen, Dorne R. Yager
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Publication number: 20020028231Abstract: The invention relates to a coating material for medical treatment, particularly a wound contact material, of resorbable, synthetic material, which is formed from a terpolymer based on lactide, trimethylene carbonate and &egr;-caprolactone with a maximum lactide content of 85 wt. %, trimethylene carbonate in the range 5 to 20 wt. % and &egr;-caprolactone in the range 5 to 20 wt. %, a method for its manufacture and its use.Type: ApplicationFiled: August 16, 2001Publication date: March 7, 2002Inventors: Helmut Hierlemann, Heinrich Planck
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Publication number: 20020026039Abstract: The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one long-chain, straight aliphatic alcohol with between 10 and 22 carbon atoms. The possible remaining non-esterified carboxylic functions, if present, are salified. The application further discloses biocompatible threads having a multifilament conformation comprising filaments formed by the aforesaid esters, and their use in the fields of medicine and surgery.Type: ApplicationFiled: August 28, 2001Publication date: February 28, 2002Inventors: Davide Bellini, Lanfranco Callegaro
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Patent number: 6264702Abstract: Composite prosthesis, comprising a non-absorbable prosthetic fabric and at least one film made of a material which is absorbable in vivo, combined with one surface of the prosthetic fabric. In combination, the prosthetic fabric has a three-dimensional structure separating its two surfaces, at least one of which is open to all post-surgical cell colonization, and the film of absorbable material is linked at least superficially to the other surface of said fabric.Type: GrantFiled: August 24, 1999Date of Patent: July 24, 2001Assignee: Sofradim ProductionInventors: Francois Régis Ory, Michel Therin
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Publication number: 20010008937Abstract: The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one long-chain, straight aliphatic alcohol with between 10 and 22 carbon atoms. The possible remaining non-esterified carboxylic functions, if present, are salified. The application further discloses biocompatible threads having a multifilament conformation comprising filaments formed by the aforesaid esters, and their use in the fields of medicine and surgery.Type: ApplicationFiled: January 25, 1999Publication date: July 19, 2001Inventors: LANFRANCO CALLEGARO, DAVIDE BELLINI
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Patent number: 6198016Abstract: The present invention provides an adhesive article that includes a backing substrate and a discontinuous adhesive layer disposed thereon, wherein the backing substrate comprises a fibrous web and absorbent particulate material, and further wherein the article has an initial wet skin adhesion of at least 20 g/2.5 cm (0.08 N/cm).Type: GrantFiled: June 10, 1999Date of Patent: March 6, 2001Assignee: 3M Innovative Properties CompanyInventors: Donald H. Lucast, Donald R. Battles
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Patent number: 6171594Abstract: An adhesive agent for application to human or animal skin, preferably for use in connection with ostomy or incontinence appliances, comprises a pressure sensitive adhesive and optionally additives conventionally used in adhesives of this kind and parts of or extracts from Aloe vera. Such adhesive prevents or alleviates skin problems.Type: GrantFiled: January 11, 1999Date of Patent: January 9, 2001Assignee: Colorplast A//SInventor: Inger Mann Nielsen
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Patent number: 6143946Abstract: A therapeutic mat for application to a person includes a relatively elastic substrate of a predetermined size, a hydrogel substance connected to the elastic substrate, and a plurality of microcrystals dispersed throughout the hydrogel substance. The therapeutic mat may further include retaining straps connectable to the elastic substrate and of a size and configuration to extend about the part of the body for supporting the therapeutic mat in a relatively fixed position.Type: GrantFiled: December 24, 1998Date of Patent: November 7, 2000Inventor: Joan E. Docter
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Patent number: 6063980Abstract: This invention relates to a cast liner that provides improved comfort over prior known cast liners. The cast liner provides several layers of material having functions which functionally complement one another. The inner layer comprises a soft highly breathable material with a first layer comprising a high wicking nonwoven material overlying the inner layer and a second layer comprising a stitch bond fabric which is relatively stiff but open and compressible to support the body through the underlying inner and first layers.Type: GrantFiled: May 5, 1998Date of Patent: May 16, 2000Assignee: E. I. du Pont de Nemours and CompanyInventors: Robert Howe Peterson, Kenneth Ashley Saum
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Patent number: 5986164Abstract: A wound dressing which comprises alginate characterized in that the alginate has a mannuronate content of 50% to 80% has a molecular weight of 7,000 to 40,000 and has a monovalent:polyvalent of from 10 to 30:70 to 90.Type: GrantFiled: May 16, 1996Date of Patent: November 16, 1999Assignee: Bristol-Myers Squibb CompanyInventors: David Kershaw, Peter Michael John Mahoney
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Patent number: 5981826Abstract: The present invention includes a poly(vinyl alcohol) hydrogel construct having a wide range of mechanical strengths for use as a human tissue replacement. A process in connection with the present invention eliminates any step involved with dehydration of the hydrogel prior to implantation thereof. The hydrogel construct may include a tissue scaffolding, a load bearing surface within a joint, or any other structure which is suitable for supporting the growth of tissue.Type: GrantFiled: September 17, 1997Date of Patent: November 9, 1999Assignee: Georgia Tech Research CorporationInventors: David N. Ku, Linda G. Braddon, David M. Wootton
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Patent number: 5944754Abstract: The invention provides compositions and methods for generating new tissue on a surface, e.g., a surface of damaged or lost tissue, of a structure or organ in a mammal, The methods involve applying a thin layer of a liquid hydrogel-cell composition to the surface; and allowing the liquid hydrogel-cell composition to solidify, thereby forming a matrix that enables the tissue precursor cells to grow and generate new tissue. The surface can be internal, e.g., the surface of an organ or the internal surface of a blood vessel, or external, e.g., skin.Type: GrantFiled: November 8, 1996Date of Patent: August 31, 1999Assignee: University of MassachusettsInventor: Charles A. Vacanti
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Patent number: 5846213Abstract: Cellulose films useful as wound and bum dressings are prepared from a solution of cellulose produced by Acetobacter xylinum in a stirred tank. The materials of this invention comprise a film of microbially produced cellulose, particularly cellulose produced from the culture of Acetobacter xylinum in a stirred tank. The film is made by dissolving the cellulose in a solvent system comprising dimethylacetamide and lithium chloride, casting the resulting solution onto a flat surface and regenerating the film in a gelation bath. Humectant is incorporated into the film by solvent exchange. The film is then sterilized and packaged for long term storage. These films are strong and elastic having mechanical properties superior to plant derived cellulose membranes and similar to that of the human skin and are useful as wound dressings.Type: GrantFiled: June 16, 1997Date of Patent: December 8, 1998Assignee: The University of Western OntarioInventor: Wan-Kei Wan
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Patent number: 5836970Abstract: Wound dressings comprising a synergistic combination of reagents comprising a blend or mixture having effective amounts of chitosan and alginate to provide an absorption capacity for wound exudate far greater than that obtainable with the same amount by weight of either chitosan or alginate alone, along with the inherent hemostatic properties of the alginate and the other biological properties of the reagents including, but not limited to fungistic and bacteriostatic properties as well as the ability to accelerate wound healing by inducing high migration of poly- and mononuclear cells toward the wound and rapid granulating tissue formation with abundant angiogenesis. The alginate and chitosan may be provided in the form of a powder, film, gel, foam or mixtures thereof. In addition to the alginate and chitosan, the wound dressing may and frequently will contain other reagents providing specific desired functions.Type: GrantFiled: August 2, 1996Date of Patent: November 17, 1998Assignee: The Kendall CompanyInventor: Abhay S. Pandit