Amino Acid, Polypeptide, Or Protein Patents (Class 602/50)
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Patent number: 12064531Abstract: A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.Type: GrantFiled: May 6, 2021Date of Patent: August 20, 2024Assignees: VENUS MEDTECH (HANGZHOU), INC., Sichuan UniversityInventors: Yunbing Wang, Yang Lei, Gaocan Li, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
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Patent number: 11931477Abstract: The invention relates to a functional wound dressing being able to provide substances supporting the healing of a wound to the wound depending on the condition of the wound. In particular, in case of an infection which is reported to be frequently associated with poorly healing wounds, such as chronic wounds, a therapeutic substance is provided to the wound whereas in other cases no therapeutic substance is provided. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.Type: GrantFiled: October 23, 2019Date of Patent: March 19, 2024Assignee: PAUL HARTMANN AGInventors: Markus Kettel, Andrew Tobias Jenkins, Laura Wallace
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Patent number: 11890371Abstract: The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein-based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder . . . ) and organ(s) (e.g. bladder, lips, vagina, penis, urethra . . . ). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.Type: GrantFiled: December 26, 2008Date of Patent: February 6, 2024Assignee: PETVIVO HOLDINGS, INC.Inventor: David B. Masters
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Patent number: 11878083Abstract: Multi component fibres for the reduction of the damaging activity of wound exudate components such as protein degrading enzymes and inflammatory mediators in wounds, the fibres comprising: from 10% to 100% by weight of the fibres of pectin and a sacrificial proteinaceous material in a weight ratio of 100:0 to 10:90 pectin to sacrificial proteinaceous material and from 0% to 90% by weight of the fibres of another polysaccharide or a water soluble polymer.Type: GrantFiled: November 9, 2021Date of Patent: January 23, 2024Assignee: CONVATEC TECHNOLOGIES INC.Inventors: Lucy Louisa Ballamy, Sharon Lam Po Tang, Marion Herbe, Alan Rogers, Sean Kelly
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Patent number: 11806370Abstract: Methods of preparing placental tissue products/compositions are disclosed together with methods of utilizing the placental tissue composition for delivery of a therapeutic agent.Type: GrantFiled: March 26, 2021Date of Patent: November 7, 2023Assignee: Plakous Therapeutics, Inc.Inventors: Scott A. Washburn, Seth Tomblyn
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Patent number: 11648011Abstract: Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.Type: GrantFiled: May 11, 2021Date of Patent: May 16, 2023Assignee: 3DT Holdings, LLCInventors: Ghassan S. Kassab, Xiao Lu
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Patent number: 11623029Abstract: Biologically acceptable surgical barrier materials are comprised of a polyelectrolytic complex of chitosan and sodium alginate. The chitosan is deacetylated in an amount between about 40 to about 60% and has a molecular weight (Mw) between 50,000 and 375,000 g/mol. The barrier materials may be formed by mixing a two-component material system whereby one component comprises the chitosan and a second component comprises the sodium alginate and directing such a mixture (e.g., via air-assisted spray nozzle) toward a surgical site in need of the material. A polyelectrolytic complex of the chitosan and sodium alginate will thereby form in situ. Suitable ionic cross-linkers may be provided in the individual components, e.g., calcium chloride with the chitosan component and sodium tripolyphosphate with the sodium alginate component.Type: GrantFiled: March 28, 2018Date of Patent: April 11, 2023Assignee: LUNA LABS USA, LLCInventors: Lauren Anne Costella, Michael J. Danilich, Christopher K. Tison, Patrick Cottler
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Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations
Patent number: 11053323Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.Type: GrantFiled: November 7, 2016Date of Patent: July 6, 2021Assignee: Covidien LPInventors: Phillip Blaskovich, Valentino Tramontano, Rachit Ohri, Joshua Kennedy, Christopher M. Henry -
Patent number: 9636362Abstract: Compositions and methods are provided for the manufacture and use of a pullulan-based collagen hydrogel film with controlled porosity. The hydrogel is fabricated with salt-induced phase inversion and cross-linking to form a reticular scaffold. This soft collagen scaffold displays excellent handling characteristics, durability, and a porous dermal-like ultrastructure that is maintained in vitro. Cells, including cells involved in tissue repair, are viably sustained within the scaffold. The hydrogel films are biodegradable, and find particular use in wound healing, where the hydrogel scaffold can be replaced by dermal cells over time.Type: GrantFiled: March 3, 2011Date of Patent: May 2, 2017Assignee: The Board of Trustees of The Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Kirit Bhatt, Jayakumar Rajadas
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Patent number: 9370604Abstract: A planar implant for replacement of biological tissues includes a layered structure including a) a lyophilized pericardium layer of biological origin, and b) at least one sponge-like layer of lyophilized extracellular protein.Type: GrantFiled: July 23, 2008Date of Patent: June 21, 2016Assignee: Aesculap AGInventors: Erich Odermatt, Juergen Wegmann, Bernd Blender
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Patent number: 9232805Abstract: A composition comprising a macromer that can be in situ polymerized into a hydrogel wound dressing directly on a wound and one or more antimicrobial agents intended to achieve bacteriostasis and/or be bacteriocidal. The antimicrobial agent is released upon application and trapped in the hydrogel upon its formation and also released over a period of time into the wound.Type: GrantFiled: June 28, 2011Date of Patent: January 12, 2016Assignee: BIOCURE, INC.Inventors: Bruktawit T. Asfaw, John C. Jackson, Zhihua Lu, Xiaowen Zhai, Sameer Shums, Thomas Hirt, Xianbo Hu, Claude-Raymond René
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Publication number: 20150132363Abstract: Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm2 of the wound facing surface of the dressing and 13.0 mg/cm2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.Type: ApplicationFiled: January 18, 2015Publication date: May 14, 2015Inventors: Martin MacPhee, Dawson Beall
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Publication number: 20140371650Abstract: A unique multi-functional emergency bandage is introduced, wherein bleeding is stopped by: (1) optimizing mechanical properties and preventing ischemia and/or necrosis while applying enough pressure to help stop bleeding, and (2) incorporating inorganic anti-bleeding nano-structures (embedded within a gauze and/or microbial cellulose) with almost infinite life-time. Additionally, pathogen passage through the bandage is prohibited (via an intermediate filter layer). Together with the overall anti-microbial character of the bandage, the unique multi-functional bandage offers all these vital features within a single design. The unique bandage can be applied by using a single hand and bandaging direction can be changed using a unique binding apparatus.Type: ApplicationFiled: June 18, 2013Publication date: December 18, 2014Inventors: Ozgur Cobanoglu, Jitka Eryilmaz, Deniz Sener, Mehmet Eryilmaz
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Patent number: 8894620Abstract: Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.Type: GrantFiled: March 7, 2012Date of Patent: November 25, 2014Assignee: KCI Licensing, Inc.Inventor: Larry D. Swain
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Publication number: 20140243726Abstract: In one embodiment, the present invention is a multi-layered bandage including a wound-contacting first layer which is porous, fluid-permeable, biodegradable, and capable of accelerating hemostasis and wound healing, and a second layer formed from an absorbent material which is releasably secured to the first layer. The first layer includes a porous, fluid-permeable, biodegradable lattice structure formed from a homogeneous mixture of collagen and a clotting enzyme which, as healing occurs, may be replaced by new tissue. The second layer may be detached at a time deemed safe, usually immediately after hemostasis occurs, without disturbing the healing process.Type: ApplicationFiled: February 27, 2013Publication date: August 28, 2014Applicant: ORTHOVITA, INC.Inventors: James San Antonio, Robert J. Chiasera, JR.
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Patent number: 8795710Abstract: A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue.Type: GrantFiled: August 22, 2008Date of Patent: August 5, 2014Assignee: Codman & Shurtleff, Inc.Inventors: Robert E. Sommerich, Laurel R. Macomber
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Patent number: 8778883Abstract: A kit for producing a foamed biocompatible material includes a container configured to sustain a high pressure, and a tissue-repair composition placed in the container. The composition contains a biocompatible material, a liquid carrier, and a gas. The container has an internal pressure of greater than 1 atm and less than 250 atm, and includes a valve and a nozzle for releasing from the nozzle a foam formed of the composition upon opening the valve. Methods of producing and applying the biocompatible material are also disclosed.Type: GrantFiled: November 13, 2009Date of Patent: July 15, 2014Assignees: Industrial Technology Research Institute, National Taiwan University HospitalInventors: Chun-Jen Liao, Sheng-Hong Tseng, Huang-Chien Liang, Yi-Chun Su, Pei-Chi Hsu
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Patent number: 8747887Abstract: A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.Type: GrantFiled: October 3, 2005Date of Patent: June 10, 2014Assignee: KCI Medical ResourcesInventor: Arthur C. Coffey
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Patent number: 8679526Abstract: The present invention discloses a class of compounds which have an enhancing effect on peroxidase based antimicrobial compositions. The invention relates to pharmaceutical compositions for prolonged topical use comprising enhancing agents such as methoxyphenols and substituted benzylaldehydes. Examples hereof are respectively guaiacol and vanillin.Type: GrantFiled: June 13, 2006Date of Patent: March 25, 2014Assignee: Flen Pharma N.V.Inventors: Dave Van Den Plas, Kris De Smet, Philippe Sollie
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Publication number: 20140046236Abstract: The present invention relates to a layered chitosan scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one of the fused layers comprises a chitosan nanofiber membrane and the other fused layer comprises a porous chitosan support layer. Moreover, the present invention provides a layered chitosan scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan scaffold. The present invention also provides a process for the preparation of the layered chitosan scaffold.Type: ApplicationFiled: May 24, 2011Publication date: February 13, 2014Applicant: UNIVERSITY OF LIEGEInventors: Patrice Filée, Astrid Freichels, Christine Jéröme, Abdelhafid Aquil, Alain Colige, Victor Tchemtchoua Tateu
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Patent number: 8647663Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.Type: GrantFiled: November 14, 2012Date of Patent: February 11, 2014Assignee: Stemnion, Inc.Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
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Patent number: 8647662Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.Type: GrantFiled: November 13, 2012Date of Patent: February 11, 2014Assignee: Stemnion, Inc.Inventors: David L. Steed, Linda O. Palladino
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Publication number: 20130245528Abstract: Provided herein is a topical wound dressing that comprises a collagen and a flexible paste. Also provided is a wound dressing with a first layer of a sterilized mixture of collagen and a second adhesive layer effective to adhere to surrounding skin and to keep the first layer in contact with the wound. In addition there is provided a wound dressing foil that comprises collagen and a plastic compound that can provide a foil shape. Furthermore, methods of dressing wounds utilizing the wound dressings and wound dressing foil are provided herein.Type: ApplicationFiled: March 13, 2013Publication date: September 19, 2013Inventor: Carl Randall Harrell
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Publication number: 20130183366Abstract: A sheet preparation characterized by that fibrinogen is held on one surface of a sheet-shaped support and thrombin is held on the other surface of the sheet-shaped support where fibrinogen is not held and that fibrinogen and thrombin are held separately from each other, and a process for preparing the same.Type: ApplicationFiled: July 14, 2011Publication date: July 18, 2013Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Hideki Saga, Tsutomu Hamuro
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Publication number: 20130096479Abstract: A hemostatic product having a plurality of hemostatic layers. Each of the hemostatic layers includes a dextran support and at least one hemostatic agent, which is selected from the group consisting of thrombin and fibrinogen. The hemostatic layers are arranged in a stacked configuration.Type: ApplicationFiled: September 19, 2012Publication date: April 18, 2013Applicant: ST. TERESA MEDICAL, INC.Inventor: St. Teresa Medical, Inc.
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Patent number: 8383147Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.Type: GrantFiled: August 22, 2012Date of Patent: February 26, 2013Assignee: Ethicon, Inc.Inventors: Dhanuraj S. Shetty, Olajompo Moloye-Olabisi, Robert W. Van Holten, Degang Zhong
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Patent number: 8377467Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.Type: GrantFiled: March 2, 2012Date of Patent: February 19, 2013Assignees: The University of North Carolina at Chapel Hill, Entegrion, IncInventors: Thomas H. Fischer, E. Stan Eskridge, Jr., William M. Malloy, Jr., Malloy Evans
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Publication number: 20130028954Abstract: The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.Type: ApplicationFiled: September 28, 2012Publication date: January 31, 2013Inventors: Martin J. MacPhee, Dawson Beall, Stanley Friedman
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Patent number: 8318197Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.Type: GrantFiled: January 17, 2012Date of Patent: November 27, 2012Assignee: Stemnion, Inc.Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
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Patent number: 8313764Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.Type: GrantFiled: June 20, 2011Date of Patent: November 20, 2012Assignee: Stemnion, Inc.Inventors: David L. Steed, Linda O. Palladino
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Patent number: 8313474Abstract: An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.Type: GrantFiled: December 17, 2007Date of Patent: November 20, 2012Assignee: HemCon Medical Technologies, Inc.Inventors: Todd D. Campbell, William P. Wiesmann, Simon J. McCarthy
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Publication number: 20120277646Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of manufacturing a therapeutic device for promoting the healing of a wound in a mammal comprising the steps of providing a permeable substrate, and forming a plurality of depressions into a surface of the permeable substrate to provide the therapeutic device. A method of treating a wound comprises: providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.Type: ApplicationFiled: July 5, 2012Publication date: November 1, 2012Applicant: BOEHRINGER TECHNOLOGIES, L.P.Inventors: John R. BOEHRINGER, John KARPOWICZ, Amitabha MITRA, Christopher L. RADL
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Patent number: 8283515Abstract: An absorbent article such as a diaper, pant diaper, adult incontinence guard, sanitary napkin and the like contains a skin conditioning agent in at least a portion of the article so as to be transferable to the skin of the wearer. The skin conditioning agent is contained in a hydrogel foam material (9; 19; 20) intended to be applied in skin contact with the wearer, either directly or indirectly via a liquid permeable material (2).Type: GrantFiled: May 2, 2003Date of Patent: October 9, 2012Assignee: SCA Hygiene Products ABInventors: Marie-Louise Lagerstedt-Eidrup, Anne Farbrot, Bo Runeman
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Patent number: 8277837Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.Type: GrantFiled: January 8, 2007Date of Patent: October 2, 2012Assignees: Entegrion, Inc., University of North Carolina at Chapel HillInventors: Thomas H. Fischer, E. Stan Eskridge, Jr., William M. Malloy, Jr., Malloy Evans
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Patent number: 8273369Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.Type: GrantFiled: May 17, 2010Date of Patent: September 25, 2012Assignee: Ethicon, Inc.Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong
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Patent number: 8183428Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.Type: GrantFiled: January 22, 2009Date of Patent: May 22, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
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Patent number: 8168850Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.Type: GrantFiled: January 22, 2009Date of Patent: May 1, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
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Patent number: 8152783Abstract: Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.Type: GrantFiled: June 26, 2008Date of Patent: April 10, 2012Assignee: KCI Licensing, Inc.Inventor: Larry D. Swain
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Patent number: 8152750Abstract: The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.Type: GrantFiled: September 13, 2004Date of Patent: April 10, 2012Assignee: Marine Polymer Technologies, Inc.Inventors: John N. Vournakis, Sergio Finkielsztein
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Patent number: 8128708Abstract: Described are methods for treating a topical wound in a patient. The methods involve applying to the wound a wound dressing including a collagenous biomaterial isolated as a sheet of tissue from urinary tract tissue of a mammal.Type: GrantFiled: January 28, 2010Date of Patent: March 6, 2012Assignee: Cook Biotech IncorporatedInventors: Michael C. Hiles, Umesh H. Patel
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Patent number: 8115048Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.Type: GrantFiled: January 22, 2009Date of Patent: February 14, 2012Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
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Patent number: 8101202Abstract: Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.Type: GrantFiled: June 9, 2005Date of Patent: January 24, 2012Assignee: Keraplast Technologies, LtdInventors: Keith Edward Branham, James Perry English, Donald R. Cowsar
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Patent number: 8063263Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.Type: GrantFiled: January 22, 2009Date of Patent: November 22, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
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Patent number: 8049059Abstract: A tissue graft product includes at least one collagen layer comprised of submucosa or renal capsule tissue having slits therein to provide a mesh pattern which in turn establishes a graft structure that is highly deformable. The slits and mesh pattern provide for improved characteristics when utilized as a tissue graft and in particular an external wound care. Preferred devices have multiple submucosa, renal capsule or other collagenous extracellular matrix layers, providing a substantial and lasting scaffold for tissue ingrowth during wound treatment.Type: GrantFiled: October 25, 2002Date of Patent: November 1, 2011Assignee: Cook Biotech IncorporatedInventors: Mark W. Bleyer, Umesh H. Patel
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Patent number: 7935364Abstract: The present invention provides a wound dressing that includes a patterned gradient of immobilized growth factor molecules that promote directed migration of cells during dermal wound healing. Growth factor is immobilized on a support substrate to present a gradient pattern of increasing growth factor concentration to migrating cells. Methods of promoting wound healing using the patterned gradient wound dressing and fabrication methods of same are also provided.Type: GrantFiled: March 4, 2008Date of Patent: May 3, 2011Assignee: Wisconsin Alumni Research FoundationInventors: Kristyn Simcha Masters, Tracy Jane Stefonek
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PHARMACEUTICAL AND COSMETIC COMPOSITIONS FOR ACCELERATED HEALING OF WOUNDS AND OTHER SURFACE DAMAGES
Publication number: 20100292625Abstract: The invention relates to biology and medicine, in particular, it can be used in medicine for preparing a pharmacological composition used for accelerated healing of wounds and the damages by means of addressed (directed) delivery of biologically active agents to mitochondria by means electrochemical potential of hydrogen ions contained therein. Said invention can be also used for producing a composition useful in transplantation surgery for preserving transplantation material and for inhibiting rejection. Moreover, the invention can be used for producing a cosmetic agent for improving state of the skin and for the revitalisation and regeneration thereof.Type: ApplicationFiled: January 29, 2007Publication date: November 18, 2010Inventors: Vladimir P. Skulachev, Maxim V. Skulachev -
Patent number: 7794450Abstract: An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.Type: GrantFiled: October 28, 2004Date of Patent: September 14, 2010Assignee: Smith & Nephew PLCInventors: Patrick Lewis Blott, Bryan Greener, Edward Yerbury Hartwell, Julian Lee-Webb, Derek Nicolini, Clare Green, Robin Paul Martin
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Patent number: 7753894Abstract: An apparatus for cleansing wounds with means for stressing the wound bed and optionally tissue surrounding the wound, in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The means for stressing the wound bed and optionally tissue surrounding the wound promotes wound healing. The dressing and a method of treatment using the apparatus.Type: GrantFiled: December 17, 2007Date of Patent: July 13, 2010Assignee: Smith & Nephew PLCInventors: Patrick Lewis Blott, Edward Yerbury Hartwell, Derek Nicolini, Clare Green, Robin Martin, Bryan Greener, Julian Lee-Webb
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Patent number: 7683234Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.Type: GrantFiled: August 3, 2007Date of Patent: March 23, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
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Publication number: 20100022932Abstract: The present invention provides a multilayer bandage, comprising a webbing for contacting a wound and a first membrane that comprises at least one water-insoluble polymer and is water-impervious. The present invention further provides methods for making the multilayer bandage, methods of using the multilayer bandage for accelerated wound healing, and kits comprising compositions of the present invention.Type: ApplicationFiled: October 1, 2009Publication date: January 28, 2010Applicant: BAYER INNOVATION GMBHInventors: Axel THIERAUF, Iwer Baecker, Andreas Haisch