Amino Acid, Polypeptide, Or Protein Patents (Class 602/50)
  • Patent number: 12064531
    Abstract: A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: August 20, 2024
    Assignees: VENUS MEDTECH (HANGZHOU), INC., Sichuan University
    Inventors: Yunbing Wang, Yang Lei, Gaocan Li, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
  • Patent number: 11931477
    Abstract: The invention relates to a functional wound dressing being able to provide substances supporting the healing of a wound to the wound depending on the condition of the wound. In particular, in case of an infection which is reported to be frequently associated with poorly healing wounds, such as chronic wounds, a therapeutic substance is provided to the wound whereas in other cases no therapeutic substance is provided. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: March 19, 2024
    Assignee: PAUL HARTMANN AG
    Inventors: Markus Kettel, Andrew Tobias Jenkins, Laura Wallace
  • Patent number: 11890371
    Abstract: The present invention relates to biocompatible protein-based particles and their methods of preparation and use. More specifically the present invention relates protein-based particles including protein matrix, spread matrix and/or biocoacervate materials derived from one or more biocompatible purified proteins combined with one or more biocompatible solvents that are used to replace or repair tissue and/or bone in treatments for spinal disc(s), joint(s) (e.g. knee, hip, finger, ankle, elbow, shoulder . . . ) and organ(s) (e.g. bladder, lips, vagina, penis, urethra . . . ). In various embodiments of the present invention the protein-based particles may also include one or more pharmacologically active agents and/or one or more additives.
    Type: Grant
    Filed: December 26, 2008
    Date of Patent: February 6, 2024
    Assignee: PETVIVO HOLDINGS, INC.
    Inventor: David B. Masters
  • Patent number: 11878083
    Abstract: Multi component fibres for the reduction of the damaging activity of wound exudate components such as protein degrading enzymes and inflammatory mediators in wounds, the fibres comprising: from 10% to 100% by weight of the fibres of pectin and a sacrificial proteinaceous material in a weight ratio of 100:0 to 10:90 pectin to sacrificial proteinaceous material and from 0% to 90% by weight of the fibres of another polysaccharide or a water soluble polymer.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: January 23, 2024
    Assignee: CONVATEC TECHNOLOGIES INC.
    Inventors: Lucy Louisa Ballamy, Sharon Lam Po Tang, Marion Herbe, Alan Rogers, Sean Kelly
  • Patent number: 11806370
    Abstract: Methods of preparing placental tissue products/compositions are disclosed together with methods of utilizing the placental tissue composition for delivery of a therapeutic agent.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: November 7, 2023
    Assignee: Plakous Therapeutics, Inc.
    Inventors: Scott A. Washburn, Seth Tomblyn
  • Patent number: 11648011
    Abstract: Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: May 16, 2023
    Assignee: 3DT Holdings, LLC
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Patent number: 11623029
    Abstract: Biologically acceptable surgical barrier materials are comprised of a polyelectrolytic complex of chitosan and sodium alginate. The chitosan is deacetylated in an amount between about 40 to about 60% and has a molecular weight (Mw) between 50,000 and 375,000 g/mol. The barrier materials may be formed by mixing a two-component material system whereby one component comprises the chitosan and a second component comprises the sodium alginate and directing such a mixture (e.g., via air-assisted spray nozzle) toward a surgical site in need of the material. A polyelectrolytic complex of the chitosan and sodium alginate will thereby form in situ. Suitable ionic cross-linkers may be provided in the individual components, e.g., calcium chloride with the chitosan component and sodium tripolyphosphate with the sodium alginate component.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: April 11, 2023
    Assignee: LUNA LABS USA, LLC
    Inventors: Lauren Anne Costella, Michael J. Danilich, Christopher K. Tison, Patrick Cottler
  • Patent number: 11053323
    Abstract: A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: July 6, 2021
    Assignee: Covidien LP
    Inventors: Phillip Blaskovich, Valentino Tramontano, Rachit Ohri, Joshua Kennedy, Christopher M. Henry
  • Patent number: 9636362
    Abstract: Compositions and methods are provided for the manufacture and use of a pullulan-based collagen hydrogel film with controlled porosity. The hydrogel is fabricated with salt-induced phase inversion and cross-linking to form a reticular scaffold. This soft collagen scaffold displays excellent handling characteristics, durability, and a porous dermal-like ultrastructure that is maintained in vitro. Cells, including cells involved in tissue repair, are viably sustained within the scaffold. The hydrogel films are biodegradable, and find particular use in wound healing, where the hydrogel scaffold can be replaced by dermal cells over time.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: May 2, 2017
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Kirit Bhatt, Jayakumar Rajadas
  • Patent number: 9370604
    Abstract: A planar implant for replacement of biological tissues includes a layered structure including a) a lyophilized pericardium layer of biological origin, and b) at least one sponge-like layer of lyophilized extracellular protein.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: June 21, 2016
    Assignee: Aesculap AG
    Inventors: Erich Odermatt, Juergen Wegmann, Bernd Blender
  • Patent number: 9232805
    Abstract: A composition comprising a macromer that can be in situ polymerized into a hydrogel wound dressing directly on a wound and one or more antimicrobial agents intended to achieve bacteriostasis and/or be bacteriocidal. The antimicrobial agent is released upon application and trapped in the hydrogel upon its formation and also released over a period of time into the wound.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: January 12, 2016
    Assignee: BIOCURE, INC.
    Inventors: Bruktawit T. Asfaw, John C. Jackson, Zhihua Lu, Xiaowen Zhai, Sameer Shums, Thomas Hirt, Xianbo Hu, Claude-Raymond René
  • Publication number: 20150132363
    Abstract: Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator, wherein the fibrinogen is present in an amount between 3.0 mg/cm2 of the wound facing surface of the dressing and 13.0 mg/cm2 of the wound facing surface of the dressing. Also disclosed are methods for treating wounded tissue.
    Type: Application
    Filed: January 18, 2015
    Publication date: May 14, 2015
    Inventors: Martin MacPhee, Dawson Beall
  • Publication number: 20140371650
    Abstract: A unique multi-functional emergency bandage is introduced, wherein bleeding is stopped by: (1) optimizing mechanical properties and preventing ischemia and/or necrosis while applying enough pressure to help stop bleeding, and (2) incorporating inorganic anti-bleeding nano-structures (embedded within a gauze and/or microbial cellulose) with almost infinite life-time. Additionally, pathogen passage through the bandage is prohibited (via an intermediate filter layer). Together with the overall anti-microbial character of the bandage, the unique multi-functional bandage offers all these vital features within a single design. The unique bandage can be applied by using a single hand and bandaging direction can be changed using a unique binding apparatus.
    Type: Application
    Filed: June 18, 2013
    Publication date: December 18, 2014
    Inventors: Ozgur Cobanoglu, Jitka Eryilmaz, Deniz Sener, Mehmet Eryilmaz
  • Patent number: 8894620
    Abstract: Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: November 25, 2014
    Assignee: KCI Licensing, Inc.
    Inventor: Larry D. Swain
  • Publication number: 20140243726
    Abstract: In one embodiment, the present invention is a multi-layered bandage including a wound-contacting first layer which is porous, fluid-permeable, biodegradable, and capable of accelerating hemostasis and wound healing, and a second layer formed from an absorbent material which is releasably secured to the first layer. The first layer includes a porous, fluid-permeable, biodegradable lattice structure formed from a homogeneous mixture of collagen and a clotting enzyme which, as healing occurs, may be replaced by new tissue. The second layer may be detached at a time deemed safe, usually immediately after hemostasis occurs, without disturbing the healing process.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 28, 2014
    Applicant: ORTHOVITA, INC.
    Inventors: James San Antonio, Robert J. Chiasera, JR.
  • Patent number: 8795710
    Abstract: A laminated, bioimplantable dural graft product is configured for use as both an onlay graft and a suturable graft. The dural graft product is sufficiently pliable so as to sufficiently conform to a curvature of a tissue surface to which it is applied, such as the curved surface of a meningeal membrane. The use of the graft product can have improved properties, including suture retention strength and fluid impermeability. To use the dural graft product as an implant to replace, reinforce or strengthen bodily tissue, or to act as an adhesion barrier, the dural graft is placed in contact with bodily tissue and conforms to the curvature of the bodily tissue. Sutures can be used to maintain the contact between the dural graft and the bodily tissue.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 5, 2014
    Assignee: Codman & Shurtleff, Inc.
    Inventors: Robert E. Sommerich, Laurel R. Macomber
  • Patent number: 8778883
    Abstract: A kit for producing a foamed biocompatible material includes a container configured to sustain a high pressure, and a tissue-repair composition placed in the container. The composition contains a biocompatible material, a liquid carrier, and a gas. The container has an internal pressure of greater than 1 atm and less than 250 atm, and includes a valve and a nozzle for releasing from the nozzle a foam formed of the composition upon opening the valve. Methods of producing and applying the biocompatible material are also disclosed.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: July 15, 2014
    Assignees: Industrial Technology Research Institute, National Taiwan University Hospital
    Inventors: Chun-Jen Liao, Sheng-Hong Tseng, Huang-Chien Liang, Yi-Chun Su, Pei-Chi Hsu
  • Patent number: 8747887
    Abstract: A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: June 10, 2014
    Assignee: KCI Medical Resources
    Inventor: Arthur C. Coffey
  • Patent number: 8679526
    Abstract: The present invention discloses a class of compounds which have an enhancing effect on peroxidase based antimicrobial compositions. The invention relates to pharmaceutical compositions for prolonged topical use comprising enhancing agents such as methoxyphenols and substituted benzylaldehydes. Examples hereof are respectively guaiacol and vanillin.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: March 25, 2014
    Assignee: Flen Pharma N.V.
    Inventors: Dave Van Den Plas, Kris De Smet, Philippe Sollie
  • Publication number: 20140046236
    Abstract: The present invention relates to a layered chitosan scaffold wherein said layered scaffold comprises at least two fused layers, wherein at least one of the fused layers comprises a chitosan nanofiber membrane and the other fused layer comprises a porous chitosan support layer. Moreover, the present invention provides a layered chitosan scaffold characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water or other solvents and a process for the preparation of such layered chitosan scaffold. The present invention also provides a process for the preparation of the layered chitosan scaffold.
    Type: Application
    Filed: May 24, 2011
    Publication date: February 13, 2014
    Applicant: UNIVERSITY OF LIEGE
    Inventors: Patrice Filée, Astrid Freichels, Christine Jéröme, Abdelhafid Aquil, Alain Colige, Victor Tchemtchoua Tateu
  • Patent number: 8647663
    Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 11, 2014
    Assignee: Stemnion, Inc.
    Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
  • Patent number: 8647662
    Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: February 11, 2014
    Assignee: Stemnion, Inc.
    Inventors: David L. Steed, Linda O. Palladino
  • Publication number: 20130245528
    Abstract: Provided herein is a topical wound dressing that comprises a collagen and a flexible paste. Also provided is a wound dressing with a first layer of a sterilized mixture of collagen and a second adhesive layer effective to adhere to surrounding skin and to keep the first layer in contact with the wound. In addition there is provided a wound dressing foil that comprises collagen and a plastic compound that can provide a foil shape. Furthermore, methods of dressing wounds utilizing the wound dressings and wound dressing foil are provided herein.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 19, 2013
    Inventor: Carl Randall Harrell
  • Publication number: 20130183366
    Abstract: A sheet preparation characterized by that fibrinogen is held on one surface of a sheet-shaped support and thrombin is held on the other surface of the sheet-shaped support where fibrinogen is not held and that fibrinogen and thrombin are held separately from each other, and a process for preparing the same.
    Type: Application
    Filed: July 14, 2011
    Publication date: July 18, 2013
    Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
    Inventors: Hideki Saga, Tsutomu Hamuro
  • Publication number: 20130096479
    Abstract: A hemostatic product having a plurality of hemostatic layers. Each of the hemostatic layers includes a dextran support and at least one hemostatic agent, which is selected from the group consisting of thrombin and fibrinogen. The hemostatic layers are arranged in a stacked configuration.
    Type: Application
    Filed: September 19, 2012
    Publication date: April 18, 2013
    Applicant: ST. TERESA MEDICAL, INC.
    Inventor: St. Teresa Medical, Inc.
  • Patent number: 8383147
    Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: February 26, 2013
    Assignee: Ethicon, Inc.
    Inventors: Dhanuraj S. Shetty, Olajompo Moloye-Olabisi, Robert W. Van Holten, Degang Zhong
  • Patent number: 8377467
    Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 19, 2013
    Assignees: The University of North Carolina at Chapel Hill, Entegrion, Inc
    Inventors: Thomas H. Fischer, E. Stan Eskridge, Jr., William M. Malloy, Jr., Malloy Evans
  • Publication number: 20130028954
    Abstract: The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 31, 2013
    Inventors: Martin J. MacPhee, Dawson Beall, Stanley Friedman
  • Patent number: 8318197
    Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: November 27, 2012
    Assignee: Stemnion, Inc.
    Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
  • Patent number: 8313764
    Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: November 20, 2012
    Assignee: Stemnion, Inc.
    Inventors: David L. Steed, Linda O. Palladino
  • Patent number: 8313474
    Abstract: An aqueous solution of polyacrylic acid is placed in a mold, frozen, and freeze-dried to form a sponge-like polyacrylic acid structure. The sponge-like polyacrylic acid structure is compressed by the application of heat and pressure to reduce the thickness and increase the density of the sponge-like polyacrylic acid structure to form a densified polyacrylic acid structure. The densified polyacrylic acid structure is preconditioned by heating to form a wound dressing. The wound dressing can be applied to control severe, life-threatening bleeding from a wound at a wound site of a person.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: November 20, 2012
    Assignee: HemCon Medical Technologies, Inc.
    Inventors: Todd D. Campbell, William P. Wiesmann, Simon J. McCarthy
  • Publication number: 20120277646
    Abstract: A therapeutic device for promoting the healing of a wound in a mammal is disclosed. An exemplary device comprises a permeable structure having a plurality of depressions formed in a surface thereof. In use, the surface having the depressions is disposed adjacent a surface of the wound. A method of manufacturing a therapeutic device for promoting the healing of a wound in a mammal comprising the steps of providing a permeable substrate, and forming a plurality of depressions into a surface of the permeable substrate to provide the therapeutic device. A method of treating a wound comprises: providing a permeable structure comprising a plurality of randomly disposed fibers and having i) a plurality of wound surface contact elements disposed between end portions of the structure, and ii) a plurality of voids defined by the contact elements; and applying the permeable structure to at least one surface of the wound.
    Type: Application
    Filed: July 5, 2012
    Publication date: November 1, 2012
    Applicant: BOEHRINGER TECHNOLOGIES, L.P.
    Inventors: John R. BOEHRINGER, John KARPOWICZ, Amitabha MITRA, Christopher L. RADL
  • Patent number: 8283515
    Abstract: An absorbent article such as a diaper, pant diaper, adult incontinence guard, sanitary napkin and the like contains a skin conditioning agent in at least a portion of the article so as to be transferable to the skin of the wearer. The skin conditioning agent is contained in a hydrogel foam material (9; 19; 20) intended to be applied in skin contact with the wearer, either directly or indirectly via a liquid permeable material (2).
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: October 9, 2012
    Assignee: SCA Hygiene Products AB
    Inventors: Marie-Louise Lagerstedt-Eidrup, Anne Farbrot, Bo Runeman
  • Patent number: 8277837
    Abstract: The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: October 2, 2012
    Assignees: Entegrion, Inc., University of North Carolina at Chapel Hill
    Inventors: Thomas H. Fischer, E. Stan Eskridge, Jr., William M. Malloy, Jr., Malloy Evans
  • Patent number: 8273369
    Abstract: The present invention is directed to a reinforced absorbable hemostat comprising at least one hemostatic agent in a single layer of nonwoven synthetic fabric having a mixture of compressed fiber staples of a polyglycolide/polylactide copolymer and a polydioxanone.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: September 25, 2012
    Assignee: Ethicon, Inc.
    Inventors: Olajompo Moloye-Olabisi, Dhanuraj S. Shetty, Robert W. Van Holten, Degang Zhong
  • Patent number: 8183428
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: May 22, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Patent number: 8168850
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: May 1, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Patent number: 8152783
    Abstract: Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: April 10, 2012
    Assignee: KCI Licensing, Inc.
    Inventor: Larry D. Swain
  • Patent number: 8152750
    Abstract: The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.
    Type: Grant
    Filed: September 13, 2004
    Date of Patent: April 10, 2012
    Assignee: Marine Polymer Technologies, Inc.
    Inventors: John N. Vournakis, Sergio Finkielsztein
  • Patent number: 8128708
    Abstract: Described are methods for treating a topical wound in a patient. The methods involve applying to the wound a wound dressing including a collagenous biomaterial isolated as a sheet of tissue from urinary tract tissue of a mammal.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: March 6, 2012
    Assignee: Cook Biotech Incorporated
    Inventors: Michael C. Hiles, Umesh H. Patel
  • Patent number: 8115048
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: February 14, 2012
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Patent number: 8101202
    Abstract: Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: January 24, 2012
    Assignee: Keraplast Technologies, Ltd
    Inventors: Keith Edward Branham, James Perry English, Donald R. Cowsar
  • Patent number: 8063263
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: November 22, 2011
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Patent number: 8049059
    Abstract: A tissue graft product includes at least one collagen layer comprised of submucosa or renal capsule tissue having slits therein to provide a mesh pattern which in turn establishes a graft structure that is highly deformable. The slits and mesh pattern provide for improved characteristics when utilized as a tissue graft and in particular an external wound care. Preferred devices have multiple submucosa, renal capsule or other collagenous extracellular matrix layers, providing a substantial and lasting scaffold for tissue ingrowth during wound treatment.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: November 1, 2011
    Assignee: Cook Biotech Incorporated
    Inventors: Mark W. Bleyer, Umesh H. Patel
  • Patent number: 7935364
    Abstract: The present invention provides a wound dressing that includes a patterned gradient of immobilized growth factor molecules that promote directed migration of cells during dermal wound healing. Growth factor is immobilized on a support substrate to present a gradient pattern of increasing growth factor concentration to migrating cells. Methods of promoting wound healing using the patterned gradient wound dressing and fabrication methods of same are also provided.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: May 3, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kristyn Simcha Masters, Tracy Jane Stefonek
  • Publication number: 20100292625
    Abstract: The invention relates to biology and medicine, in particular, it can be used in medicine for preparing a pharmacological composition used for accelerated healing of wounds and the damages by means of addressed (directed) delivery of biologically active agents to mitochondria by means electrochemical potential of hydrogen ions contained therein. Said invention can be also used for producing a composition useful in transplantation surgery for preserving transplantation material and for inhibiting rejection. Moreover, the invention can be used for producing a cosmetic agent for improving state of the skin and for the revitalisation and regeneration thereof.
    Type: Application
    Filed: January 29, 2007
    Publication date: November 18, 2010
    Inventors: Vladimir P. Skulachev, Maxim V. Skulachev
  • Patent number: 7794450
    Abstract: An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: September 14, 2010
    Assignee: Smith & Nephew PLC
    Inventors: Patrick Lewis Blott, Bryan Greener, Edward Yerbury Hartwell, Julian Lee-Webb, Derek Nicolini, Clare Green, Robin Paul Martin
  • Patent number: 7753894
    Abstract: An apparatus for cleansing wounds with means for stressing the wound bed and optionally tissue surrounding the wound, in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The means for stressing the wound bed and optionally tissue surrounding the wound promotes wound healing. The dressing and a method of treatment using the apparatus.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: July 13, 2010
    Assignee: Smith & Nephew PLC
    Inventors: Patrick Lewis Blott, Edward Yerbury Hartwell, Derek Nicolini, Clare Green, Robin Martin, Bryan Greener, Julian Lee-Webb
  • Patent number: 7683234
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: March 23, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Reinhold H. Dauskardt, Michael T. Longaker, Paul Yock
  • Publication number: 20100022932
    Abstract: The present invention provides a multilayer bandage, comprising a webbing for contacting a wound and a first membrane that comprises at least one water-insoluble polymer and is water-impervious. The present invention further provides methods for making the multilayer bandage, methods of using the multilayer bandage for accelerated wound healing, and kits comprising compositions of the present invention.
    Type: Application
    Filed: October 1, 2009
    Publication date: January 28, 2010
    Applicant: BAYER INNOVATION GMBH
    Inventors: Axel THIERAUF, Iwer Baecker, Andreas Haisch