Abstract: An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other.

Abstract: Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.

Abstract: An adhesive bandage dispensing system comprises a bandage retaining and dispensing spool and a continuous elongated bandage strip wound around the spool. The bandage strip comprises a plurality of individual adhesive bandages serially connected to one another at perforated edges. The perforations are oriented transverse to the elongated direction of the bandage strip and structurally weaken the bandage strip so that individual bandages may be separated from the bandage strip at the perforation lines by application of removal force thereto. The bandage strip is sized and shaped to ensure that absorbent pads of the bandage strip are sealingly enclosed by the bandages strip itself. The invention, thus, provides a bandage dispensing system which prevents contamination of the individual bandages without the need for additional packaging materials. Numerous advantageously shaped spools for use in the bandage dispensing system are disclosed.

Abstract: A prosthetic tissue patch includes a sheet of material having first and second sides, with a plurality of macrochannels extending parallel to each other in the plane of the sheet, and defining a dispersed set of chambers that serves as a reservoir of pharmaceutical material or living culture. The channels communicate through pores in the thin surrounding wall with a surface of the sheet which is placed in contact with tissue and may intergrow therewith. The sheet is preferably 0.2-2.0 mm. thick, with the macrochannels each having a diameter between about 0.1 and 1.5 mm, generally no more than about three quarters of the sheet thickness. A preferred embodiment is formed of polytetrafluoroethylene (PTFE) with an anisotropic porosity structure of nodes which may be oriented generally transverse to the plane of the sheet. The channels are initially filled either by conventional methods, or by insertion of solid filaments of material, and may be capped closed by a special plug.

Abstract: A surgical dressing consisting of a film which carries an adhesive layer wherein the film has a hydration rate of at least 0.1 g/in.sup.2 /min.; becomes saturated when in contact with water in 3 minutes or less and absorbs at least its own weight of water. The film comprises a polyethylene oxide and a polymer or polymers selected from an ether based polyurethane and a polyether block amide. The dressing finds special use as a IV catheter site cover.

Abstract: A method of inhibiting the stretching of the skin to prevent damage to the skin, and resulting stretch marks (striations) on a woman's abdominal area during pregnancy, by transversely taping an adhesive-backed polyurethane sheet over the affected area for a major portion of the pregnancy period.

Abstract: A conformable material is described which comprises a backing layer having an adhesive layer on a first surface and a removable protector covering the adhesive layer and a removable carrier layer on the non-adhesive surface of the backing layer. The carrier layer and the protector layer are provided with slits substantially the length of the longitudinal or major axis.

Abstract: A multidose transdermal drug delivery system comprises a laminate composite with a plurality of compartments. Each compartment is a reservoir for a unit dose of a drug active to be transdermally administered. The assembly is adhesively secured to the skin of a patient. Individual seals are provided for resealably enclosing the drug active in each of the reservoirs. The individual enclosing seals are removable to release the unit dose into contact with the skin of the patient and are actuable to control the transdermal absorption of the drug actives. Provisions are also made to automatically indicate the activation of the drug and to prevent an accidental release of medicament.

Abstract: The present invention is directed to a topical composition for the treatment of psoriasis. The composition comprises a film forming agent, especially vinyl acetate crotonic acid copolymer a plasticizer, an aqueous alcoholic solution and an amount of alkali effective to prevent the gellation of the film forming agent.

Abstract: A transdermal therapeutic formulation is made of a composition comprising a polymer and ingredients mixed with the polymer which are a pharmacologically active substance, an alcohol, a percutaneous absorption promoter utilized according to necessity and water utilized according to necessity. The polymer comprises lipophilic monomer units and hydrophilic monomer units in a specific ratio. The alcohol, the percutaneous absorption promoter and water are mixed with the polymer in specific amounts. The transdermal therapeutic formulation has excellent percutaneous absorption, has many kinds of applicable pharmacologically active substances, shows good stability of percutaneous absorption with time because of absence of crystallization of the pharmacologically active substance, has good adhesive strength and thus favorably utilized as transdermal therapeutic plaster.

Abstract: Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.

Abstract: An improved medical dressing, including a dressing layer having a first face and a second face, the first face having an adhesive coating on at least a portion thereof; a release layer covering the dressing layer in releasable contact with the adhesive face of the dressing layer; a support layer covering the dressing layer in releasable contact with the second face of the dressing layer, the dressing layer having smaller surface dimension than the release layer and the support letter, the support layer having on at least one side thereof a U-shaped perforation therethrough, the perforation extending from an area adjacent an edge of the support layer and overlapping the smaller surface dimension of the dressing layer; and a delivery means for applying the dressing layer to a wound site, the delivery means pivotally mounted on a portion of the support layer adjacent the base of the U-shaped perforation.

Abstract: The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer such as polylactides, polyglycolides, polycaprolactones or copolymers thereof in a pharmaceutically acceptable solvent such as N-methylpyrrolidone, alcohols or alkyl esters. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid such as water, saline solution or body fluid to coagulate or solidify the film onto the human or animal tissue.

Abstract: There are described padding materials comprising a first moisture vapor permeable film layer and a second moisture vapor permeable film layer with air bubbles spaced therebetween. The air bubbles may optionally contain foam pips. Methods of preparation and uses of the padding materials are also described.

Abstract: A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.

Abstract: Chlorhexidine gluconate-containing adhesives have dispersed therein solid chlorhexidiene particles which will pass through a 125 .mu.m sieve and at least about 30% of the total volume of particles has a size of not less than 5 .mu.m. The adhesive may be a vinyl ether adhesive and may be coated upon a backing layer such as a hydrophilic polyurethane to produce products suitable for use as wound dressings, IV dressing or incise drapes. The chlorhexidine gluconate may be obtained as a freeze-dried solid and added directly, in suspension, to the adhesive mass without further milling.

Abstract: An orthopedic appliance for reinforcing a patient's skeletal anatomy from a rigid shell fitted at the inside to the patient at skin overlying the skeletal anatomy to be reinforced, has an improvement for adhering the rigid shell to the skin of the patient. A strip of flexible tensile tape has a first side for fitting to the skin of a patent and a second side outward exposed for fitting to the inside of the rigid shell. A hypoallergenic non-inflammatory adhesive is coated on one side of the strip of flexible tape for fitting to the skin. Means for removable attachment to the inside of the rigid shell is placed on the second side of the strip of flexible tape for outward exposure and attachment to the rigid shell. Complimentary means for removable attachment is fitted to the inside of the rigid shell. This attachment transfers loading from the skin of the patient to the rigid shell for orthopedically reinforcing the skeletal anatomy of the patient.

Abstract: This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.

Abstract: A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.

Abstract: A polyvalent cation crosslinked pectin fiber composition is composed of a calcium sensitive low methoxyl pectin with a degree of esterification (DE) of less than 15% or calcium sensitive amidated pectin having a DE of less than 50% where the pectin is polyvalent cation crosslinkable and has an average molecular weight (MW) having an upper limit of 200,000 and a lower limit of 5000. This pectin is useful in making wound dressings for topical applications.

Abstract: An adhesive bandage having a flexible backing element with a generally circular central region and a plurality of salient points radially extending from the central region giving the bandage a generally star-shaped or asterisk-shaped appearance. Wherein, the shape of the bandage helps the bandage protect and cover cuts on flexible parts of the body, such as the fingers and toes, without buckling and exposing the cut to the surrounding environment.

Abstract: Disclosed is a device for delivering tissue adhesives and/or sealant patches to a surface which covers or surrounds a lumen, cavity or organ, or potential lumen or cavity, within a human or other animal. Also disclosed is a method of delivering tissue adhesives and/or sealant patches to a surface which covers or surrounds a lumen, cavity or organ, or potential lumen or cavity. The method is particularly suited to sealing perforations in vascular walls, such as after arterial access for Percutaneous Transluminal Coronary Angioplasty (PTCA), Percutaneous Coronary Angiography and Percutaneous Coronary Atherectomy and similar diagnostic and therapeutic procedures.

Abstract: A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of an adhesive overlay, a backing layer underlying the central portion of the adhesive overlay, an active agent-permeable membrane, the backing layer and membrane defining a reservoir that contains a formulation of the active agent, a peel seal disc underlying the active agent-permeable membrane, a heat seal about the periphery of the peel seal disc, the active agent-permeable membrane and the backing layer and a removable release liner underlying the exposed overlay and peel seal disc. The adhesive layer is above and peripheral to the path of the active agent to the skin or mucosa and is protected from degradation by the components of the reservoir by a multiplicity of heat seals. The peel seal disc protects against release of the active agent-containing reservoir and the release liner protects the adhesive from exposure to the environment prior to use.

Abstract: A composition comprising a cross-linked salt of (a) a polyvinylpyrrolidone having ring opened pyrrolidone groups; (b) at least one acrylic acid-containing or methacrylic acid-containing polymer; and (c) an amine-containing polymer. The composition may be used as a pressure-sensitive adhesive, has good tack, and may be peeled from the body or from an object without causing damage or injury to the body or object.

Abstract: A dressing comprising a skin friendly pressure-sensitive continuous or discontinuous adhesive layer (2), which is coated on one side with a non-adhesive flexible polymer film (1 a) and which is optionally coated on the other side with a removable release layer (3), said polymer film (1a) consisting of an uppermost layer (4) of a material which is relatively hard, and a lowermost layer (5) of a material which is relatively soft, said lowermost layer (5) being thicker than the uppermost layer (4). The dressing has a low surface friction and a good flexibility.

Abstract: An improved wound dressing composite is disclosed, having a membrane film wound dressing, a relatively stiff substantially planar carrier sheet with tabs, and a releasable cover. The film dressing has an upper surface, a lower adhesive surface and opposed side edges for application in a spread out disposition to a wound site with the lower surface adhered thereto. The film dressing, being relatively thin, is substantially unable to support itself in a planar configuration. The carrier sheet has an upper surface, a lower surface, and opposed edges. The carrier sheet is releasably adhered on its lower surface to the upper surface of the film dressing in supporting relation for supporting the film dressing in a planar configuration, with the side edges of the film dressing and carrier sheet generally aligned in close adjacency.

Abstract: A transdermal delivery system for the modulated administration of drugs is described. The drug delivery device comprises a backing; a drug reservoir containing the drug, a plasticizer-type enhancer, a solvent-type enhancer, and optionally, a gelling agent; a non-rate-controlling membrane; and an adhesive layer containing a plasticizer-type enhancer. This drug delivery system is particularly useful for the administration of tolerance-inducing drugs, for example, vasodilators, such as isosorbide dinitrate.

Abstract: Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant.

Abstract: This invention relates to an adhesive sheet material, such as an adhesive tape, which is suitable for use on wet surfaces, in particular upon wet skin. The adhesive sheet material effectively binds to the wet surface and moves moisture away from the surface. The adhesive sheet material has a porous backing having opposing sides and is made of non-wettable fibers. The water-insoluble pressure sensitive adhesive is discontinuously coated on one side of the backing to provide areas of the adhesive interspersed with areas of bare backing.

Abstract: Angiographic vascular occlusion agents comprising a biopolymer alone or in combination with platelet-rich plasma. A liquid biopolymer gels in situ in contact with divalent cations. Biopolymer agent achieves permanent occlusion, biopolymer combined with the platelet-rich plasma achieves temporary or semi-permanent occlusion. The plasma is obtained from the patient's own blood to avoid undesirable immunogenic reactions. The occlusion agents have strong occlusive properties when injected into a bleeding vessel.

Abstract: A wound covering comprising a film formed of a polyurethane resin, or a laminate of the polyurethane film and an absorptive cloth, wherein the polyurethane film or the cloth contains an antibacterial agent, and perforations are formed at least on the polyurethane film.

Abstract: Anti-adhesion films useful for the prevention of surgical adhesions are disclosed. These films comprise substrate materials (such as collagen) and hetero-bifunctional anti-adhesion binding agents, wherein the substrate material is covalently linked to receptive tissue within the body of a patient via the binding agent. Preferred binding agents comprise substrate-reactive and tissue-selective functional groups. Anti-adhesion compositions useful for the formation of such films are also disclosed.

Abstract: A wound dressing possessing a wound exudate-absorbing component and at least one liquid-impermeable dressing-securing component is manufactured from the same flexible, cellular, thermoplastic resin workpiece.

Abstract: Ad adhesive composition suitable for wound dressing and other medical applications comprising a mixture of polyisobutylene and a rubber polymer selected from the group consisting of random styrene butadiene copolymer (SBR) and halobutyl rubber so as to form a rubbery elastomer base matrix, and at least one hydrocolloid. The addition of the SBR or halobutyl rubber to the elastomer base offsets the possible degradation of the polyisobutylene upon sterilization, and therefore, helps to maintain the integrity of the composition. Water soluble hydrocolloid gums and water swellable cohesive strengthening agents are dispersed within the base matrix and may carry a pharmaceutical agent to be dispensed directly to a wound site.

Abstract: A fastening system includes a membrane assembly which can comprise a pair of body panels secured together at a seam. The membrane panels can comprise a semi-permeable material. A sheath assembly has a tubular configuration with proximate and distal ends and a sheath passage extending therebetween. The sheath assembly can be fastened to the membrane assembly by adhesively securing the sheath assembly adjacent to its proximate end between the membrane panels at the membrane assembly seam. A sheath-to-tube fastener is provided for fastening the sheath assembly to a tube. In one embodiment of the present invention a surgical sponge is fastened to the membranes in fluidic connection with the sheath, which is fastened to a suction tube for drawing blood from a surgical site.

Abstract: This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.

Abstract: Autologous platelet-rich plasma and a biocompatible polymer containing hemostatic adhesive agents. The agents have strong hemostatic properties when applied to a bleeding wound or vessel.

Abstract: A flexible, transparent wound dressing product contains a clear hydrogel material in a gel-like phase. The wound dressing product is comprised of several layers including a wound dressing, removable tab and release liner. The removable tab provides a grippable surface to allow for the removal of the release liner from the wound dressing and to facilitate handling of the wound dressing during application to the wound site. The tab may be comprised of a flat, double-coated paper or other suitable material, or a flexible, V-shaped member, and is removable by peeling after the wound dressing is applied. The wound dressing comprises a transparent thin-film layer, a first adhesive layer, backing layer, second adhesive layer, support layer and a hydrogel material. The transparent layer has a center portion and a perimeter portion. The backing layer, support layer and hydrogel material, which together form a reinforced hydrogel patch, are positioned in the center portion of the transparent layer.

Abstract: A skin-friendly dressing which has a high moisture absorbing capacity, a high degree of flexibility and good integrity. The dressing includes a moisture-absorbing adhesive sheet to be adhered to the skin and mucous membranes, with a layer of water swellable colloid which is dispersed in or mixed with a water insoluble viscous elastomer binder and, if desired, usual auxiliary materials. The adhesive sheet at one outwardly directed surface is firmly connected to a non-adhesive water impervious cover layer, and at the other, against-the-skin or mucous-membrane directed surface of the adhesive sheet, a removable protecting sheet. The adhesive sheet is provided with one or several grooves or ditches that fully or partly surround a central part of the adhesive sheet.

Abstract: A sheet material, coated with a surgical adhesive comprising an NCO-terminated urethane prepolymer, is used for bonding of tissues, with improved handleability.Surgical instruments, comprising a non-adherent material towards an NCO-terminated urethane prepolymer, are used for application of surgical adhesive. Such instruments, comprising a rod tapered so that the tip can be partly inserted into blood vessel, are suitable for anastomosis of blood vessel.

Abstract: Disclosed is a device in the form of an adhesive tape stripping which in consequence of its configuration and presence of glue surfaces thereon facilitates the isolation of sawed particles of a cast material, for example, to the area of cutting as the material is being cut or sawed. Thus, for example, when a casting material is ready to be removed from a limb, the protective tape of the invention is applied to the cast in such a manner as to orient the cutting path preferably along the center of the tape. In a preferred case, a guide line is drawn on the tape for such purpose. The process of cutting generates the particles which instead of being dispersed into the atmosphere are accumulated on the adhesive surfaces of the trapping tape and are also embedded into the body of a thicker bottom adhesive layer of the tape thereby obviating the need for any vacuum equipment material and the associated personnel required therefor.

Abstract: A skin irritation alleviation agent composed of a polyoxyalkylene-modified organopolysiloxane is provided. Various compositions including skin external application compositions, cosmetic or similar compositions (e.g., an adhesive composition for a false eyelash, a decolorant composition, a depilatory composition, and an eyeliner composition) containing a polyoxyalkylene-modified organosiloxane are also provided. This alleviation agent has a low skin irritation effect and extremely high safety factor when used on the human body.

Abstract: An adhesive composition suitable for wound dressing and other medical applications comprising a mixture of polyisobutylene and a rubber polymer selected from the group consisting of random styrene butadiene rubber (SBR) and halobutyl rubber so as to form a rubbery elastomer base matrix, and at least one hydrocolloid. The addition of the SBR or halobutyl rubber to the elastomer base offsets the possible degradation of the polyisobutylene upon sterilization, and therefore, helps to maintain the integrity of the composition. Water soluble hydrocolloid gums and water swellable cohesive strengthening agents are dispersed within the base matrix and may carry a pharmaceutical agent to be dispensed directly to a wound site.

Abstract: A stratiform pad for surrounding and protecting a bed sore from pressure while the patient is in bed. The pad comprises a median layer containing a closed cell air bubble film, a body-contacting layer bonded to one surface of the median layer to adhere the pad to the patient's body, and a bed-contacting layer bonded to the other surface of the median layer to adhere the pad to the bed surface. The pad contains an interior bed sore receiving aperture and provides sustained lift of the body away from the bed in the area of the sore, thus relieving the pain of pressure and providing space for the flow of healing air.

Abstract: A sheet material, coated with a surgical adhesive comprising an NCO-terminated urethane prepolymer, is used for bonding of tissues, with improved handleability.Surgical instruments, comprising a non-adherent material towards an NCO-terminated urethane prepolymer, are used for application of surgical adhesive. Such instruments, comprising a rod tapered so that the tip can be partly inserted into blood vessel, are suitable for anastomosis of blood vessel.

Abstract: The present invention relates to thermoplastic membranes which are selectively permeable to water or water vapor and which can be simply produced by the lamination of a thermoplastic sheet onto an absorbent material at or around the glass transition temperature of the thermoplastic.

Abstract: A thermal bandage apparatus for simultaneously dressing and thermally treating a wounded bodily area includes a fluid absorbent member having a wound contacting surface for absorbing bodily fluids produced by an open wound and holding means adjacent and connected to the fluid absorbent member for holding a thermal medium against the fluid absorbent member such that heat is transferred between the thermal medium and the open wound by thermal conduction through the fluid absorbent member. There is also disclosed an arrangement for providing a continuous supply of heat or cold to a wound.

Abstract: A new polymer, the feed monomers and molar percents of which, exclusive of a polymerization initiator and crosslinker, are:A. (I) 42 mole % to 58 mole % of a siloxy silane of formula I,(II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II,(III) 0 to 5 mole % of a Group A monomer, and(IV) 0 to 16 mole % of an additional vinylic copolymerizable monomer;B. (I) 42 mole % to 58 mole % of a siloxy silane of formula I,(II) 21 mole % up to less than 42 mole % of an unsubstituted alkyl (meth)acrylate of formula II,(III) 0 to 5 mole % of a Group A monomer, and(IV) 0 to 29 mole % of an additional vinylic copolymerizable monomer; orC. (I) 16 mole % up to less than 42 mole % of a siloxy silane of formula I,(II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II,(III) 0 to 5 mole % of a Group A monomer, and(IV) 0 to 36 mole % of an additional vinylic copolymerizable monomer;where formula I is ##STR1## where formula II is ##STR2## in which R.sub.

Abstract: A transdermal drug delivery system is disclosed. The system comprises a laminate composite of a patch/skin permeable membrane; a transfer gel layer disposed on said permeable membrane; a permeable membrane disposed on said transfer gel layer; a plurality of sectional drug reservoirs for receiving medicament disposed on the transfer gel layer; and activation means for releasing medicament from said drug reservoirs for contact with skin of a patient. The medicament in contained in the reservoirs at varying amounts and/or concentrations, providing for selectable dosage, for sequential delivery, for sequential activation, for variable unit dose drug delivery in transdermal application.

Abstract: A tape for attaching bandages, with non-adhesive tabs at each end for easy manipulation and removal while wearing gloves is disclosed. Also disclosed are tapes with target markings for location of a puncture wound, tapes with pressure disks or plates attached, and methods of making and using the tapes.