Abstract: It is an object of the invention to provide a label which enables a user to recognize information necessary when using a medicine bag in a reliable fashion. A label includes a base part 12 indicating thereon basic information including at least information on ingredients of medicines accommodated in a medicine bag 1 and a detachable part 14 detachably joined to the base part 12. The label is characterized in that the detachable part 14 is so shaped as to be attachable to such an area of the medicine bag 1 that it becomes difficult to use the medicine bag 1 when a surface of the area is covered, and the detachable part 14 indicates thereon characteristic information including at least directions on use of the medicine bag 1.

Abstract: A home pharmacy kit provided to organize, educate, simplify and add convenience to the consumer regarding self-treatment with over-the-counter (OTC) drugs and self-management of therapy with widely and commonly used OTC medications. The kit of the invention allows a consumer to achieve appropriate therapy when self-medicating and allows a consumer to avoid therapeutic duplication and over utilization and/or underutilization of medications, which may result from a lack of consumer related to the action and effects of common active ingredients found in a wide variety of cold and cough combination drug products as well as in gastrointestinal combination drug products.

Abstract: The invention relates generally to materials for facilitating the administration of dimethyl sulfoxide (DMSO) and related compounds. In one embodiment, the invention comprises a kit comprising items used for the safe and effective administration of DMSO. In another embodiment, the invention relates to indicating containers for holding or delivering DMSO.

Abstract: A vial for dispensing a liquid into a syringe is described which comprises a body section for holding the liquid, the body section having a top and a bottom; a port having a removable seal, where the port is adapted for a syringe connection and where the port is interconnected with the body section at a point near the top of the body section by a passageway which for at least a portion of its length extends above the level of the liquid in the body section when the vial is inverted, thereby preventing leakage of the liquid from the body section when the seal of the port is removed. A method of making the vial is also described.

Abstract: A disposable syringe having both graduated marks and a label describing the medicine contained in the syringe, obtained according to a method which involves feeding an orderly succession of syringes having the graduated marks on the body towards a labeling station; feeding an orderly succession of adhesive labels, each having a transparent portion, towards the labeling station; synchronizing each syringe with the respective label so that, subsequently, the transparent portion is placed over the graduated marks; and wrapping the respective label around the body of each syringe, first bringing a longitudinal edge of the label into contact with the syringe body then rotating the syringe about its own longitudinal axis.

Abstract: The label is executed as strip-shaped and adhered as directed in a self-overlapping fashion to a syringe body (1) which is inserted in a syringe protector formed from an insert (5) and a receiver (4). In the longitudinal direction of the strip it successively has a base section (11), two voucher sections (12a, 12b), a protective section (13), a holding section (14) and a grip tab (15). The label can be unrolled and pulled out from the syringe protector by a grip tab (15) so that the voucher sections (12a, 12b) are freely accessible. If necessary, after inserting the syringe body (1) into the syringe protector, the grip tab (15) can be extracted through lateral openings (24, 25) to a certain extent by gently turning the syringe body (1) relative to the syringe protector and then gripped since the grip tab (15) is at some distance after sticking the label onto the syringe body (1).

Abstract: This invention provides methods for treating a subject afflicted with a proliferative disorder comprising administering to the subject a therapeutically effective amount of an agent which inhibits the expression of p46 Shc and/or p52 Shc, inhibits the activity of p46 Shc and/or p52 Shc in the subject, or increases the level of phosphorylated p66 Shc in the subject. This invention also provides methods for determining whether an agent inhibits the phosphorylation of p46 Shc or p52 Shc; inhibits the dephosphorylation of p66 Shc comprising; or an agent inhibits the binding of a Shc A protein with a protein to which the Shc A protein must bind in a cell in order to carry out its proliferative function. This invention also provides articles of manufacture for use in treating a proliferative disorder in a subject.

Abstract: A living tissue transportation method includes the steps of: putting the living tissues in a carrying container for transportation (1) having a first memory storing an identifier and an IC tag (10) having a temperature sensor; putting the carrying container (1) in an individual carrying container (2) having a second memory for storing the identifier and a second IC tag (20) having a temperature sensor; storing a copy of the identifier of the IC tag (10) in the memory of the IC tag (20) and putting the individual carrying container (2) in a transportation container for constant temperature (3). A controller (30) provided in the transportation container (3) communicates with the IC tags (10, 20), and writes information indicating a temperature abnormality to the first and second memories when the temperatures of the carrying container (1) and the individual carrying container (2) are out of a predetermined temperature range.

Abstract: A blood donation device with a receptacle for a blood donation container and a control section at which utensils required by the operator can be accommodated and/or by means of which parameters of the donation process can be varied, detected and/or retrieved. Bending of the operator to the blood donation device is avoided by the fact that the control section is arranged in an elevated position with respect to the receptacle of the blood donation device.

Abstract: A system of marked medical containers comprises at least two containers having different properties in at least one respect, and at least one machine-readable marking on each of the containers, each marking being designed to allow discrimination between the difference in properties. Each marking allows discrimination between the difference by having at least one area with different absorbence or reflectance when irradiated with radiation in non-visible frequency ranges. A specific container comprises a syringe cartridge type container for use with a preparation delivery device.

Abstract: A method and device for identifying, testing or clearing a prefilled medicinal syringe in which the syringe is inserted into the test device which reads coding on the syringe and has a display as to whether the syringe is appropriate or not.

Abstract: A surgical sponge detection system includes a plurality of surgical sponges (2) having radio frequency identification tags (1) securely attached thereto and a non-optical hand-held reader (40) for detecting the sponges by detecting the tags (1). Also disclosed is a device (30) for automatically counting, weighing, and calculating blood loss contained within, soiled surgical sponges (2) which includes a cabinet with an opening (3) at the top through which sponges (2) are deposited, a reader (6) which scans each sponge (2) entered and determines sponge type from a tag (1) affixed to each sponge (2), and a disposable bag (8) into which the sponges (2) are deposited.

Abstract: A device for accessing biological fluid, sampling biological fluid constituents and determining the concentration of at least one target constituent within the accessed biological fluid is provided. The device has at least one micro-piercing member used to penetrate the skin to a selected depth and to access biological fluid, a constituent sampling means and a constituent measuring means. The constituent sampling means comprises a constituent transfer medium, such as a hydrophilic gel material, by which sampled constituents are transferred from the micro-piercing member to the measuring means. The measuring means includes an electrochemical cell having at least one porous electrode through which at least one sampled constituent is caused to enter into the electrochemical cell. Methods of sampling constituents within the skin and measuring the sampled constituents, as well as kits for practicing the invention are provided.

Abstract: A comprehensive system (10) for the growing, analyzing, storing, validating and distributing of cells or tissues for a variety of purposes, in which the comprehensive system (10) generally uses a macrocontainer (12) for each of the steps from beginning to end. The macrocontainer (12) may include a number of elements, an essential one of which is the primary container (14). In every case, the primary container (14) includes a biosensor and a data registry device (15) (usually a microchip) to record and to display the handling history of the primary container (14) throughout the implementation of the system (10). The macrocontainer (14) provides process control, sterility and a matrix within and around which associated inlets, outlets and data lines may be coordinated.

Abstract: A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a selected characteristic of the blood product.

Abstract: The present invention provides a biochip comprising, in sequence from one end of a blood collection bag formed into a flat, pouch-like shape using a flexible material:

Abstract: A medical material and a medical device comprising an aromatic vinyl compound/&agr;-olefin random copolymer according to the present invention, are materials which contain substantially no chlorine and which have not only excellent flexibility, transparency and proper resilience but also radiation resistance and biocompatibility, and they are hence advantageously used especially in the medical field.

Abstract: A prewarning device for instillation of medical liquid includes a throttling cylinder having a tubular needle connected to an open top thereof. A pointed head portion of the tubular needle is inserted into a medical liquid bottle for the medical liquid to flow into the throttling cylinder via the tubular needle. A portion of the tubular needle between the head portion and the throttling cylinder is transparent for a clamp to clamp therearound. A sensor is provided on the clamp to connect to a warning unit via a wire. The tubular needle defines a downward tapered inner space to receive a float therein. When the medical liquid bottle becomes empty, the float lowers in the tubular needle and is sensed by the sensor for the latter to actuate the warning unit to sound. The lowered float also blocks up the tubular needle to stop air from passing therethrough.

Abstract: A urine collection cup device is provided including a clear plastic cup, a reagent strip disposed against an inner surface of the cup and adhered thereto by means of a plastic laminate or adhesive member. An aperture is provided in the adhesive member on a sample introduction end of the reagent strip to enable a fluid sample to be introduced onto the reagent strip. By capillary action the fluid migrates up the reagent strip and causes a visible indication of test validity and test results. A second aperture covered with a hydrophobic material is provided adjacent the reagent strip end to enable air to vent from the strip while preventing fluid specimen from entering therein.

Abstract: A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a characteristic of the blood product. When the pH value drops to a predetermined level, the substance begins to erode, causing the pores to enlarge, and allowing a portion of the blood product to pass through the pores into the contained space, where it can be visibly detected. The contained space may contain a chemical indicator or buffers and nutrients, which are released into the blood product when the pores begin to open. In another embodiment, the microporous membrane may be in the form of a pod or capsule which may be attached to the wall or allowed to free-float within the contents of the storage container.

Abstract: The invention relates to: A method of providing an electronically readable item of information (725) on a medication cartridge (70). The invention further relates to a cartridge (70) containing an electronically readable item of information (725), a support (75) for reading the information (725) on the cartridge (70), a medication delivery device adapted to use a cartridge (70) and a support (75) according to the invention and a label (72) containing an electronically readable item of information (725). The object of the present invention is to provide an alternative method of generating an electronically readable item of information on a cartridge which method is simple and improves safety in reading. The problem is solved in that said item of information is redundantly provided (725, 726). The invention may e.g. be used in connection with medication delivery devices for self-treatment of a disease, e.g. diabetes.

Abstract: A cell storage maintenance and monitoring system includes a blood product storage container, such as a flexible bag, and a microporous membrane which may be attached to an inner wall of the blood storage container to form a contained space between the inner wall and the membrane. The membrane includes a plurality of pores, preferably filled with an erodible substance responsive to a characteristic of the blood product, such as pH. When the pH value drops to a predetermined level, the substance begins to erode, causing the pores to enlarge, and allowing a portion of the blood product to pass through the pores into the contained space, where it can be visibly detected. The contained space may contain a chemical indicator or buffers and nutrients, which are released into the blood product when the pores begin to open. In another embodiment, the microporous membrane may be in the form of a pod or capsule which may be attached to the wall or allowed to free-float within the contents of the storage container.

Abstract: A bottle having a sterility seal and a method for producing same are disclosed. The bottle, which can be configured to retain a medicament in powder or tablet form, features a protective cap configured to engage a transfer assembly associated with the bottle. The cap includes one or more raised ridges on an interior surface engageable with a portion of the transfer assembly. A band or layer configuration of a sealing material such as silicone is applied to the transfer assembly prior to insertion of the cap thereover. As the cap comes into surface contact with the sealing material, the ridges cause the material to “roll up” into a toroidal O-ring configuration, thereby forming a seal between the cap and the bottle adapted to the dimensional variations of those components.

Abstract: A container for examination and storage of a placenta includes a bottom wall, at least one substantially upright side wall joined to the bottom wall to define an interior and an open top. The side walls and/or the bottom wall have indicia thereon adapted to measure the size of the placenta in three dimensions. Indicia are also provided to measure the umbilical cord. The container is stackable for storage, and labeling areas are provided. A basic method of examining a placenta is disclosed, along with further steps and variations.

Abstract: To provide a plastic vessel containing an albumin preparation which completely restrains formation of thermally denatured albumin, a plastic molded member in a cylindrical shape is extruded in a molten state into opened dies, one end of which is closed in the dies, and a vessel is molded by blowing a compressed gas into the molded member in the dies or by bringing inner portions of the dies into a vacuum state. While the vessel is still disposed in the dies, an albumin preparation is introduced from an opening portion into an inner portion of the vessel and, therefore, the albumin preparation can be filled into the vessel in a sterilized state without being brought into contact with the atmosphere. Then, an opening portion of the vessel filled with the albumin preparation is hermetically sealed at an internal temperature of the opening portion of about 40° to 70° C. Thus formation of thermally denatured albumin can be completely restrained.

Abstract: A semen storage container containing the semen of a male pig is sealed with a stopper having a cone-shape vomiting portion whose point is closed at one end when the semen is used for artificial insemination, a predetermined portion of the cone-shape vomiting portion of the stopper is cut inserted into an insertion tube which is then inserted into the womb of female pig, thereby easily and cleanly carrying out artificial insemination. A window for confirming the amount of semen stored is added to the semen storage pack who se exterior is shading-printed to block a harmful ray of light such as direct ray of light, protecting the semen from deterioration.

Abstract: An improved test device for the testing of a fluid having a cup and a cover lid, such cover lid having a reagent test strip chamber containing a reagent test strip, a fluid receipt chamber, a fluid channel containing a fluid-passing pad and a fluid contact chamber. An actuation cover with a window defined therein is positioned over the regent test strip chamber, fluid receipt chamber, fluid contact chamber, such window positioned over the color change area of the reagent test strip. The actuation cover forms a fluid-tight seal around a first end of the reagent test strip which protrudes into the fluid contact chamber. After the cup is filled with fluid and the cover lid is positioned thereon, the cup is inverted, causing fluid to flow into the fluid receipt chamber through an aperture in said cover lid.

Abstract: Device for the transfusion of blood or hemo-derivatives including: a blood or hemo-derivatives container; a device for the transfusion of blood or hemoderivatives to the patient; and a device for connecting the container to the device for the transfusion; the device for connecting includes a joint formed by two central tubular mutually connectable members, both provided with complementary coding devices, and device for locking the connectable members together.

Abstract: For an apparatus for the extra-corporal treatment of blood wherein blood is supplied from a body to a vacuum bottle via a conduit, an insertion spike for piercing a closure plug of a vacuum bottle has a front end with a pointed tip and includes a first passage extending from the front end to a connecting piece for connection to a gas supply means, the front end having a perforated side wall for the diffused discharge of gases admitted through the first passage and a second passage having means for connection to a blood conduit and extending to an opening in the side of the insertion spike adjacent the perforated side wall.

Abstract: This invention relates to a method and apparatus for concentrating motile erm from a sperm sample, including concentrating sperm in the vicinity of one or more oocytes for in vitro fertilization. The method comprises placing a volume of fertilization medium in a container, said container having at least one microchamber and being shaped such that the fertilization medium, when placed in the container, fills the microchamber and a portion of the container outside of the microchamber, such that when a sperm sample is placed in the medium outside the chamber motile sperm swim into the microchamber, where they may be harvested or, if an oocyte is in the microchamber, in vitro fertilization occurs.

Abstract: An improved test device for the testing of a fluid having a cup and a cover lid, such cover lid having a reagent test strip chamber containing a reagent test strip, a filling chamber, and a cutting chamber. An actuation cover with a window defined therein is positioned over the reagent test strip chamber, filling chamber and cutting chamber, such window positioned over the color change area of the reagent test strip. The actuation cover forms a fluid-tight seal around a first end of the reagent test strip which protrudes into the filling chamber. A pointed member is disposed under an actuation button in the cutting chamber. After the cup is filled with fluid and the cover lid is positioned thereon, the operator depresses the actuation button, forcing the pointed member through the floor of the cutting chamber to form an aperture therein. The test device is then inverted, allowing the fluid to pass through the thus formed aperture into the cutting chamber.

Abstract: A blood sample/fluid system includes a pair of tubes formed of identically shaped concentric cylinders, each closed at one end and open at the other end and having different diameters enabling the reduced diameter tube to be positioned in the enlarged diameter tube. A locking ring is positioned around the outer surface of the reduced diameter tube to provide a spacer and seal for the enlarged diameter tube. An identifying label is positioned on the outer surface of the enlarged diameter tube for providing identity for both tubes when the tubes are engaged and for the enlarged diameter tube when the reduced diameter tube is removed from the enlarged diameter tube.

Abstract: A testing device having a lower cup for receipt of a fluid specimen and a cover lid containing a strip chamber having one or more reagent strips disposed therein and having a test chamber for each of the reagent strips, such test chamber receiving the end portion of the reagent strip, with each of the reagent strips having a color change testing area along its length. The cover lid is attachable to the cup in fluid-tight relationship with the device to be inverted for the fluid specimen to reach the reagent strips in the test chambers and react therewith, and for the device to be set upright for the reading of the color change testing areas through windows in the cover lid above the color change test areas.

Abstract: An improved device and process of assuring separation of an anticoagulant type fluid from a saline type fluid each of which is utilized in the process and operation of a plasmapheresis apparatus or the process of collecting donor blood, is disclosed. The improvement includes a cross-spike prevention receptacle which is dimensioned, and installed positionally in reference to a plasmapheresis or blood donor apparatus, to receive an anticoagulant fluid container to which a proper respective supply communication line will connect, and to exclude and not receive a saline fluid container or container holding a similiar type of fluid, whose fluid line will not reach and connect to the installed cross-spike prevention receptacle.

Abstract: A safety closing device for containers of biological liquids and, particularly, for test tubes used for the drawing, transport and/or analysis of blood. The safety closing device includes an undercap and a cap, both with central portions made of a perforable material. The central portion of the undercap is sealingly locked on the edge of the test tube and the central portion of the cap is sealingly locked on the side facing the undercap. A locking mechanism, that can only be intentionally disengaged, mechanically couples the cap to the undercap, and secures the cap/undercap assembly onto the prearranged open end of the test tube.

Abstract: A testing device having a lower cup for receipt of a fluid specimen and a lid containing a chamber having one or more reagent strips protruding therefrom, such reagent strips having color change testing areas thereon. The lid is attachable to the cup with the device to be inverted for the fluid specimen to reach the protruding reagent strips and for the device to be set upright for the reading of the color change testing areas through a transparent area of the lid.

Abstract: A tamper-resistant closure for a medical injection device such as a syringe includes a cap having both a blind bore sized to receive and seat tightly against the syringe tip, to prevent material from entering or being withdrawn from the device. The cap has a threaded connection to the syringe tip, and is entirely covered by a loose-fitting shield having a one-way drive mechanism which prevents the cap from being unscrewed from the device while the shield is in place. The shield has at least one internal, frangible tang protruding obliquely into the envelope of the cap, so that the shield and cap can be easily assembled, but cannot thereafter be disassembled without breaking the tang and thus providing an indication of tampering.

Abstract: The present invention is directed toward an apparatus and a method which can use immunoassay in sample treatment apparatus for diagnostic and testing purposes of urine by concentrating specific urine antigen in a small volume area and concentrating the urinary sediments in a separate small volume area. Urine is transported through the tubular container under pressure to flow through the sample container which screens off the urinary sediments and the beads so that antigens carried in the urine are collected and concentrated on the beads.

Abstract: An apparatus for collecting and testing multiple biological markers comprising a tubular compartmentalized container holding covalently bound antigen beads and correlating anti-antibody beads contained in separated compartments. The biological fluid, namely urine, is collected in the tubular container and is forced to flow through the separated compartment of the compartmentalized container so that predetermined ligands become attached to the bead ligands to obtain a plurality of biological markers.

Abstract: The present invention describes package units for medical purposes, in particular for receiving and/or storing sterilizable preparations for parenteral uses or dialysis solutions, comprising a container having at least one discharge spout and consisting of polyamide 66 or a laminate of polyamide 66 sheet and polyolefin sheet, the polyolefin sheet being disposed on the side facing the liquid to be stored and the sheet of polyamide 66 being disposed on the outside and the two sheets being bonded together in usual manner by means of an adhesive. The package units may further comprise an inner container or an outer container. The package unit is made in that a container having at least one discharge spout is made from polyamide 66 or the aforementioned laminate, said container filled with the liquid to be stored, then sealed and sterilized and possibly subsequently surrounded after cooling and drying with an outer container of polymeric material.

Abstract: An analytical specimen cup (10) has outer and inner partitions (26, 34) in a lid (14) thereof, with the outer partition being flexible and transparent and the inner partition having a valve (46) comprised of a frangible portion (50) of the inner partition. A chemical test strip (24) is mounted in a test space (42) between the outer and inner partitions and a fluid specimen in the cup can be introduced to the chemical test strip in the test space by manipulating the frangible valve (46) to break it open via the flexible outer partition. The inner partition is formed as a one-piece lid main member (22) with most of the rest of the lid whereas the outer partition is mounted to cover an indentation (30) into a top surface of the lid main member to define the test space in the indentation.

Abstract: An apparatus for recycling autologous blood from a patient for reinfusion back to the patient comprising suction means, admixing means for admixing aspirated blood with a washing fluid, filtering means for filtering the admixture through an emboli filter and a membrane filter, monitoring means for measuring the amount of cellular component volume in the filtered blood, filtration means for removing excess fluid and particulates from the blood, and reinfusion means is disclosed. Embodiments for use during surgery for on-line purification and reinfusion on a real time basis are disclosed along with embodiments for use post-surgically when the wound site is closed and drainage tubing has been implanted at the wound site to draw off blood post-surgically. Methods for performing the autotransfusion process are also disclosed.

Abstract: An apparatus for testing biological molecular indicators in blood comprising a tubular container, and a sample compartmentalized container holding labelled ligands and beads with immobilized ligands. Blood is collected in the tubular container under pressure to flow through the sample compartmentalized container which screens off the red blood cells so that enzymes of the labelled ligands are carried by the blood fluid to a reactant solution which is colored by specific labelled ligands to indicate the presence of specific ligands.

Abstract: An apparatus for collecting and testing multiple biological markers comprising a tubular compartmentalized container holding covalently bound antigen beads and correlating anti-antibody beads contained in separated compartments. The biological fluid, namely urine, is collected in the tubular container and is forced to flow through the separated compartment of the compartmentalized container so that predetermined ligands become attached to the bead ligands to obtain a plurality of biological markers.

Abstract: Liquid level monitoring apparatus for monitoring the level of a liquid in a container having a wall with an exterior surface and an interior surface and formed of a material which is substantially transparent to optical energy and which has an index of refraction different from that of the liquid. The apparatus comprises an optical sensor holder and adhesive means adapted to secure the sensor holder to the exterior surface of the container at a predetermined level. A sensor head is provided. An attachment mechanism is carried by the sensor head and the sensor holder for detachably mounting the sensor head on the sensor holder. A self-contained power supply is provided which is coupled to the sensor head.

Abstract: A device for the preparation of sterile pharmaceutical solutions for intravenous use includes a first bag (1), a second bag (8), and a filtration unit (5). The filtration unit (5) has an inlet tube and an outlet tube, the inlet tube of the filtration unit (5) being attached to an outlet port in the first bag (1) and the outlet tube being connected to an inlet port through which aqueous solvent may be introduced. The first bag (1) has a flexible lining that defines a chamber and a plurality of individual storage containers (3) attached to the lining of the chamber. The containers (3) have tops that may be snapped off by manipulation of the lining opposite the chamber. The removal of the container allows ingredients contained within to be individually released into the chamber on demand. The combination of the ingredients and the aqueous solvent forms a pharmaceutical solution of known composition.

Abstract: Blood bag having affixed thereto a label, portions of which are adapted to permit enhanced gas transmissibility between the interior and exterior of the bag. In preferred embodiments the affixed label has an outwardly facing surface adapted to provide useful information about the bag or bag contents and an inwardly facing surface having raised portions and depressed portions with the label generally adhering to the bag surface via only the raised or selected raised portions.

Abstract: A liquid container is packaged in a box having a removable handle which also acts as a closure device for the opening and closing of the box. The liquid may be bulk sterile fluids, chromatography buffers, industrial enzymes packaged in glycerol, liquid nutrient solutions, and similar liquids. The container comprises an inner bladder made of polyvinyl chloride. The inner bladder is wrapped in a carbon dioxide/oxygen gas barrier. This gas barrier may be in the form of a plastic bag. The gas barrier reduces or prevents the deterioration of the liquid in the inner bladder. The inner bladder has three ports for accessing the liquid. These ports are of a septum-type which can indicate tapering, The inner bladder also has a fill tube for use in filling, and a metal hook for hanging if the inner bladder, is removed from the box. The box is designed to support weight sufficient to allow stacking of several boxes with associated filled inner bladders.

Abstract: A tamper evident closure apparatus is described in which a closure sensing switch is positioned inside of a container for nonprescription drugs and the like for producing a lid removal signal upon the removal of the lid from the container. A sound signal generator responds to the lid removal signal and generates an auditory sound of safety signal informing the person opening the container that the lid has not been previously removed. A safety circuit also responds to the removal of the lid and inhibits the sound signal generator from responding to a second or subsequent lid removal signal so that the replacement and subsequent removal of the lid will not trigger the generation of a second sound of safety signal.

Abstract: A composite body fluid sample container is provided which incorporates at least one dry chemistry test strip into the structure with a shrink-wrap film whereby a plurality of chemically impregnated patches are exposed simultaneously in a self-contained device to provide instant response to a specimen introduced into the container. Moreover, the device separates the test strip from the remainder of the specimen so as to provide for additional testing if required. In addition, the device maintains the specimen, and the impregnated test strip isolated from exposure to contamination while at the same time keeping the specimen, if diseased, from contaminating handlers of the device. Finally, the device protects against breakage and any resulting leakage or contamination.