Abstract: A biological sample collection tube suitable for use in collecting and processing blood samples, is of high strength, transparent plastic. The tube wall is substantially gas impermeable, permitting the retention of samples therein, under conditions of vacuum, for prolonged periods. The selected material is combustible in air, yielding products of combustion that are substantially non-toxic, to facilitate the safe disposal of the tubes, together with the enclosed samples. The tube is made of plastic copolymer or monomer resin such as polyethylene, polypropylene or polyamide. A preferred material group is amorphous nylon, in particular Nylon 6 (T.M.) such as polyethylenenaphthalate and ethylene vinyl alcohol. The tube may be made from a combination of such materials by mechanical integration in manufacture, through co-extrusion, co-injection, or by a dual material indexed molding process.

Abstract: An air-evacuated blood collection tube assembly comprising an air-evacuated tubular container having an open end and a closed end, and a cannula-penetrable self-sealing gas-proof closure in sealing engagement with the open end of the container so as to maintain the vacuum inside the container. The closure has an end interior of the container and an end exterior of the container. The end interior has a first notch formed adjacent to the container wall. The end exterior includes a first notch that is aligned with the notch on the end interior of the container. The tubular container is formed of a polyethylene terephthalate material. The open end of the tubular container is flared outwardly. A hump extends inwardly of the inner diameter of the tubular container. The closure has an indented ring that is formed so as to receive this hump during engagement with the tubular container.

Abstract: A closure or cap for a reagent container for use in an analysis system in which an automatic pipetting device is used for transferring small quantities of reagent from the reagent container to reaction cells. In order to simplify the process of handling the reagent container in an automatic analysis system, the closure is characterized in that it is formed in one piece from a plastic and it has a cylindrical side wall and an annular top wall adjacent the side wall and merging into a conical wall which extends inwards from the inner circle of the top wall and ends in a piercable tip situated on the axis of symmetry of the cylindrical wall.

Abstract: A syringe filling and metering device (2, 90) for pharmaceutical containers (4) including a variable volume region housing the liquid pharmaceutical (78) and a needle access portion, such as a septum (74) or piston (104), which is pierced by the needle cannula (72) of the syringe (6), such as by mounting the syringe in a syringe carrier (8). An elongate piston stop (58) is held in place by a piston driver (42) to which the syringe carrier is threadably connected. The syringe carrier is screwed into the piston driver to drive the barrel of the cartridge over the piston, thus forcing the contents of the cartridge through the needle cannula and into the syringe. The invention can also be practiced with the needle cannula piercing the piston so that the movement of the piston into the barrel of the container forces the liquid pharmaceutical through the needle cannula and into the syringe.

Abstract: A protection system is provided for the transfer of toxic liquid from a bulk container through a first conduit to a connector for a delivery device such as a dosage syringe. A second conduit connects the connector to a waste receptacle. The first and second conduits penetrate the closed end of a flexible barrier bag. The bag is initially retracted from the bulk container to allow manipulation of the bulk container. The bag is subsequently extended over and sealed around the bulk container and waste receptacle to protect the health care provider during liquid transfer to the deliver device.

Abstract: An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9, wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing sufficient NaHCO.sub.3 to maintain the pH thereof between about 7.0 and about 7.6, and further containing from about 0.0004 moles of dissolved CO.sub.2 per ml of composition up to the saturation level of dissolved CO.sub.2 at a CO.sub.2 head pressure of up to about 2.5 atmospheres.

Abstract: This invention relates to bags for the cryopreservation of mammalian cells and particularly for the long-term freezing of red blood cell. This invention also relates to methods of manufacturing such bags.

Abstract: An elastomeric stopper for a fluid-containing bottle to hermetically seal the content therein and to provide access thereto by the insertion of an infusion device through the stopper, the stopper comprising an annular protuberance which forms a second seal with the shaft of the infusion device to prevent leakage, blow-out and introduction of particulate matter into the bottle.

Abstract: A hypodermic syringe which can be filled with liquid medication for injection into a subject only from a container of the liquid under pressure greater than the ambient pressure around the syringe includes a moveable piston in a cylinder and an injection needle extending from one end of the cylinder defining a liquid dosage space between the piston and the needle and on the other side of the piston in the cylinder is a piston stem that extends from the other end of the cylinder and is manipulated by the user to inject a liquid from the dosage space under the force of the piston out of the needle, the piston and the piston stem being adapted so that the stem can be manipulated to push the piston toward the needle, but the stem cannot be manipulated to pull the piston away from the needle, and the position of the stem in the cylinder can be adjusted at any of a plurality of positions that limit the travel of the piston away from the needle and so limit the volume of the liquid dosage space defined between the p

Abstract: An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9, wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing sufficient NaHCO.sub.3 to maintain the pH thereof between about 7.0 and about 7.6, and further containing from about 0.0004 moles of dissolved CO.sub.2 per ml of composition up to the saturation level of dissolved CO.sub.2 at a CO.sub.2 head pressure of up to about 2.5 atmospheres.

Abstract: A quick release tamper evident closure device for disposable fluid medical storage bags. The closure device comprises an outlet port section and a closure cap section sealed together. The outlet port section is sealed to the bag and includes a tubular member for discharging the fluid in the bag. The outer end of the tubular memeber extends inside a cavity formed in the cap section. A tear path is formed around the cap section for severing the cap section from the port section to provide access to the tubular member. The tear path includes opposed curved portions merging into an apex. A handle extends outward from the cap section and aligned with the apex for applying an outward force which is initially concentrated at the apex, to cause ripping of the closure cap at the apex and then along the remainder of the tear path. The handle includes an opening and is flexible for varying the dimensions of the opening to accommodate the various sized finger inserted therethrough.

Abstract: An ampul for containing a physiologically acceptable liquid comprises a tubular body made of a non-toxic, chemically inert thermoplastic material having an elongation at break ranging from about 100% to about 200%, a tensile strength at break less than about 15,000 psi and a flexural modulus less than about 400,000 psi. The tubular body has at least one end portion of reduced cross-sectional dimension formed with a peripheral line of weakness enabling the end portion to be manually fractured. The ampul according to the invention is impact-resistant and forms a clean cut when the end portion is fractured to dispense its content, thereby eliminating dangerous shards.

Abstract: This invention relates to containers for the cryopreservation of mammalian cells and particularly for the long-term freezing of red blood cell. This invention also relates to methods of manufacturing such containers.

Abstract: A fluid dispensing apparatus is provided which comprises a flexible, collapsible fluid container in fluid communication with an adjustable volume multi-dose dispensing means.

Abstract: A pre-slit injection site includes a housing with a flow path therethrough. A first end of the housing carries a pre-slit septum. A blunt cannula, usable with the injection site, carries a locking member. When the pre-slit injection site slidably receives the blunt cannula the locking member latches to the injection site forming a mechanically coupled unit.

Abstract: A closure device for connection to a fluid container which has an opening for receiving the device. The closure device has a base section which may sealably cover the container opening. The base section has a spike receiving opening passing there through with at least one air vent on the base section which is spaced from the spike receiving opening. A hydrophobic air filter, is associated with the air vent. Adjoining the base section is an internal cover, which lies over the aperture, covering it and the base section. The internal cover has a pierceable portion which is in alignment with the spike receiving opening of the base section.

Abstract: The present invention is directed to a device for sterile coupling and decoupling of a first solution system to a second solution system. The first system has a resealable member so as to allow access into the system. The device includes a housing for receiving the resealable member so as to provide a fluid tight cooperating engagement with the resealable member. A penetrable barrier is positioned in the housing across from the resealable member. A conduit in flow communication with the second system is adapted for sterile penetration of the barrier and the resealable member. An inlet and outlet duct provides a passageway between the barrier and the resealable member. The inlet is adapted for fluid flow from a source of sterilizing fluid and optionally a sterile rinsing fluid. The outlet duct receives the sterilizing fluid after is passes across and sterilizes the resealable member facing the barrier.

Abstract: A dispenser cap for use with a fluid container having an aperture through a flexible portion of a stopper closing the mouth of the container comprises a main body portion and a fluid communicating spike extending through the body portion. The spike has an outer diameter of sufficient size to form a seal with and to permit flexing of the flexible portion of the container stopper upon insertion of the spike in the stopper and upon movement of the cap toward the flexible portion of the stopper. The main body portion of the dispenser cap comprises a disk portion with a skirt extending from the disk portion and circumferentially encircling the container stopper.

Abstract: An ampoule is disclosed having a stopper slidably mounted therein adjacent the proximal end and a rubber diaphragm secured to the distal end. An aperture barrier is provided in the ampoule between the proximal and distal ends, and has an aperture sealed by a plug. Sterile acidified liquid local anaesthetic is contained in an proximal compartment defined in the ampoule by the barrier and the stopper. Sterile alkaline neutralizing reagent is contained in the distal compartment defined in the ampoule by the barrier and the rubber diaphragm. In use, the ampoule is placed in the barrel of a hypodermic syringe, and is then manually advanced in the barrel toward the distal end of the syringe to cause the proximal end of the hypodermic needle of the syringe, which proximal end extends into the barrel of the syringe, to perforate the rubber diaphragm and communicate with the distal compartment of the ampoule. The distal end of the hypodermic needle is then inserted into the oral tissues of the patient.

Abstract: A port/spike assembly including an enteral spike having a diameter substantially less than the diameter of a standard parenteral spike. The assembly also includes a port having a tube with an outer wall which defines a generally cylindrical elongated bore. A frangible membrane is disposed inside the elongated bore, and divides the bore into upper and lower bore sections. A selector ring is provided in the upper bore section for permitting insertion of the reduced diameter enteral spike and for preventing the insertion of a standard parenteral spike through the membrane. The assembly prevents inadvertent insertion of a parenteral spike into an enteral feeding system.

Abstract: A wedge-shaped access port for a flexible container is described. The flexible container is formed of at least one or more sheets of material which are sealed together about the edges to form a cavity. The wedge-shaped port is sealed to the container so that a base of the wedge is exterior to the cavity and a thin edge of the wedge is located inside the cavity. An orifice in the port provides a passageway from the base of the wedge to the cavity. The wedge shape of the port allows sealing of the port to container with minimal stress or thinning of material at the seal between the port and the container.

Abstract: A closure arrangement for pharmaceutical bottles contains a stopper closing the bottle mouth, and a closure cap mounted over the bottle mouth and a closure cap. The stopper is adapted to be pierced with a hollow needle for extracting a medicament located in the bottle. The closure cap is provided with a tear-off disc which is located above the stopper and is removable upon opening the closure. The tear-off disc is produced from plastic material in one piece with the closure cap and is retained thereat by means of a weakening line. Between the tear-off disc and the stopper there is provided a spacer which does not extend beyond the outline of the tear-off disc. The spacer is formed in one piece with the tear-off disc and/or with the stopper. The closure cap can be one-handedly pressed in the direction toward the bottle, whereby the tear-off disc is separated from the closure cap and the stopper is free for insertion of a hollow needle.

Abstract: A container has a body made of superimposed layers of flexible plastics film and a port sealed between said layers. The port comprises superimposed layers of flexible plastics material which provide a channel. A layer of non-sealable material is located in said channel during sealing of the port to the container body so as to prevent the opposing surfaces of the channel from being sealed together, said non-sealable layer being thereafter removed. Preferably the port comprises two layers of film united at one end thereof and along opposite sides thereof to provide the channel with a rupturable closure at the one end.

Abstract: A nozzle member is mounted to a medical solution container for providing an inlet port of an additional medical solution introduced into the container by means of a needle. The nozzle member comprises a tubular body and a synthetic resin sealing membrane mounted within the tubular body. Projections are formed on both surfaces in the central portion of the sealing membrane so as to prevent the sealing membrane from being strained or cracked in the step of thermally sterilizing the medical solution container.

Abstract: One of the two confined volumes, for example the "supplying" one (2), is provided with a tubular perforating element (3) confined within a space closed by a diaphragm or perforable wall (503); the second confined volume (1) also has a perforable diaphragm (301); the surfaces of the two diaphragms (503, 301) directed towards the external environment are permanently bonded together after which the perforator (3) is manipulated from the outside so as to perforate the two diaphragms, placing in communication, via the tubular duct of the perforator, the confined environment of the supplying volume with that of the second volume.

Abstract: A blood aerator comprises an aerating vessel having a vessel body provided with ports for a gas- and liquid-tight connection to a blood hose and at least one gas hose. A simplified and reliable handling is permitted in that a port for the blood hose and a port for a lower gas hose are separately provided on the bottom portion of the vessel body, the port for the lower gas hose contains a hydrophobic filter element, which is impermeable to blood and permeable to gas, and the port for a second gas hose is provided on the top portion of the vessel body.

Abstract: A collapsible container of a synthetic resin foil for receiving liquid substances, especially dialysis concentrates and having a filling fitting, a discharge fitting and at least one grip in which one or both of the fittings can be integrated.

Abstract: The present invention comprehends the provision of a fluid tight holding chamber which accumulates solution from the vial that aspirates during mixing or drawing fluid from the vial or is pressured out of the syringe upon extraction of the cannula from the vial. The holding chamber is defined in conjunction with the vial septum by a shield cap that surrounds and seals to the neck of the vial. The shield cap defines a guide for the cannula of the syringe and directs the cannula through a sealing member, the holding chamber, the septum and into the vial. One aspect of the invention provides a sleeve portion on the shield cap that receives and retains the syringe barrel. An arm is provided on the sleeve portion and has a notch that holds the syringe barrel in a predetermined position during shipment and storage of the assembly.

Abstract: A port and closure assembly for a container is provided. The port and closure assembly includes a port having a tubular portion that extends from a base and terminates at an end including an opening. The tubular portion is divided into an upper and lower section by a pierceable membrane. The upper section including an end that terminates at the opening and including a resealing injection site. A closure member for removably surrounding at least a portion of the end of the port including the opening is provided. The closure includes a sleeve that circumscribes at least a portion of an outer surface of the upper section of the tubular portion. The sleeve is so constructed and arranged as to cause portions of the upper section to contact the resealing member during a sterilization step that softens the portions and further causes the portions of the upper section to retain the resealing injection site within the tubular portion after the portions have hardened.

Abstract: A lyophilization container device comprising a top end having at least one lyophilization port axially extending upward and defining a generally polygonally oval shape. The device includes a bottom end having generally the same shape as the top and having preferably a substantially flat bottom. Also included is a wall portion sealed to the top and bottom end to define the container, with the wall portion having an inside surface which is drug compatible and has sufficient buckle strength to withstand vertical force during stopper seating.

Abstract: A medical solution container includes a bag portion for storing solution and a header portion which incorporates an improved outlet port in communication with the bag portion for receiving and holding a spike from an administration set. The outlet port has, at a distal end from the bag portion, a generally inwardly inclined tapered annular collar which, at its widest diameter portion, joins a substantially cylindrical coaxial bore section. The cylindrical bore section has a first section with a reduced diameter which adjoins a second section having an enlarged diameter. The second section is located at an end of the outlet port proximate the bag. A pierceable diaphragm for sealing the outlet port is supported at the junction of the reduced and enlarged diameter bore sections and lies substantially in a plane which is at an angle to a normal to the insertion direction of the spike or the axial direction of the cylindrical bore. By providing the diaphragm at an angle, which is preferably between about 5.degree.

Abstract: A universal connector is described, being capable of both connection with female luer connectors and penetration of resealable-diaphragm connection sites. The connector comprises a tubular member defining a first tubular section having a distal end capable of resealably penetrating a latex resealable-diaphragm injection site. Aperture means are provided adjacent the distal end of the tubular member for communication with the lumen of the tubular member with the exterior. The tubular member also defines a frustoconical male luer section positioned proximally of the first tubular section and proportioned to be sealable with female luer connectors. The male luer section has a minimum diameter that is greater than the maximum diameter of the first tubular section. Annular step means are provided separating the first tubular section and male luer section, and means are provided, spaced proximally of the frustoconical male luer section, for providing connection with a fluid conduit.

Abstract: A liquid collection tube for collecting blood or like liquid with a liquid collection needle, comprises a tube member with a bottom and a cap member removably fitted on an open end of the tube, with thread structures. A sealing member is interposed between the cap member and open end of the tube member to enhance the close contact between the two. The sealing member is not bonded to the open end of the tube member, and it can be removed together with the cap member to open the open end of the tube member when the cap member is removed from the tube member. The cap member has a through hole permitting a re-sealing member of the sealing member to be pierced from the outside.

Abstract: A disposable tray assembly forming a housing for an aspiration kit is disclosed. The tray assembly includes a base and an upper tray member sealingly connected to the base to define a sealed internal chamber or reservoir for extracted fluids. Access to the reservoir is provided by an elastomeric plug through which a needle may be inserted. A soluble capsule filled with disinfectant is in registry with the plug so that fluids discharged by the neeedle are subjected to the disinfectant.

Abstract: According to the present invention, a vial cap is provided which has two openings, one for receiving the neck of a syringe and allowing medicine to flow into the syringe, and another for allowing air to flow into the vial as medicine is extracted. A safety lid to the vial cap is preferably provided for assuring sterility. A membrane may also be provided to cover the interior surface of the vial cap so that no medicine leaks into the region between the vial cap and its safety lid while the medicine is being transported and stored.The shape and size of the two openings may be varied according to the application, in particular according to the material used for the cap and the medicine being stored in the vial.

Abstract: The blood collecting tube of the present invention has a tubular body that is opened at one end and closed at the other end and a sealing member which is bonded to the peripheral edge of the opening of the tubular body so as to seal this opening.

Abstract: A device for sealing a container intended to be connected to a recipient provided with a connector for supply of its contents to the recipient in such a way that the container can be applied to and removed from the recipient without leakage and is sealed after the removal. For this purpose an elastic body is included in the device, which contains a cavity with a thin bottom, which cavity is adapted to the connector and is inclined relative to the longitudinal axis of the body, so that the interior portion of the body is displaced radially time of application of the device to the connector and opens a channel between the body and the container wall for air supply to the container. The interior portion of the cavity is smaller than the exterior portion of the connector to enable the connector to open the sealing device by widening a normally closed hole or slit located at the bottom of the cavity.

Abstract: A vial containing liquid contents constructed so as to permit transfer of its contents to a syringe without the use of a needle with the syringe. One embodiment employs rotation of a cap to align openings avoiding the use of a needle. In another embodiment, there is provided mounted within apparatus located on the mouth of the vial a needle which is built in to the apparatus. The syringe engages the needle which is then depressed to puncture the cork sealing the vial, the vial is then inverted, and the contents drained into the syringe. The needle is withdrawn thereby resealing the contents of the vial, and the needle remains with the vial.

Abstract: A blood collecting tube comprises a tubular member made of synthetic resin which has an open end and a closed bottom, and a closure member which is for closing the open end of the tubular member and allows a puncture needle to pierce therethrough, the interior of said blood collecting tube being kept under reduced pressure, said tubular member being essentially made of a polyester resin mixture of a polyester resin mainly based on a ethylene glycol and terephthalic acid and a polyester resin mainly based on ethylene glycol and isopthalic acid. The tubular member of this blood collecting tube can be suitably made by injection molding and has high gas barrier properties so that the capability of collecting blood decreases little with time.

Abstract: A package comprising a package container structure having an open end leading into an interior chamber therein, a package lid structure mounted over the open end of the package container structure in generally sealed relation with the interior chamber thereof so as to be moved into opening relation thereto, and a device for use with a medicament vial disposed within the sealed interior chamber. The device and package container structure have interengageable elements disposed out of interengagement when the device is disposed within the sealed interior chamber operable when the package lid structure is moved into opening relation and the device is moved out of the open end of the interior chamber to be moved into interengagement. The device and package container structure with the interengaging elements thereof interengaged provide a generally sealed interior space including the interior chamber within which a medicament vial is contained in cooperating relation with the device.

Abstract: A method for use when making mutually different analyses on organic body fluids which, when taken as samples from a patient, are drawn into a so-called vacuum tube 1 which is hermetically sealed by means of a rubber stopper 2 or the like. The device comprises a pressure-equalizing and sample-retrieval cannula 3 having a penetrating pipe 4 with a pointed end intended to penetrate the rubber stopper 2. The other end of the pipe 4 merges with a seating for receiving a cuvette, pipette or like collecting vessel, provides with a suction hose 11 which extends through the pipe 4 and into the vacuum tube 1. The seating is an integral part of a holding device provided with downwardly projecting fixation means 6 which embrace the rubber stopper 2 and hold the cannula 3 in position, so as to enable the vacuum tube 1 to be centifuged with the cannula in position.

Abstract: A plug device for a transfusion container comprising a plug body made of rubber having an air passing portion into which a water repellent but air-permeable filter of porous material is inserted, a sealing sheet adapted to cover at least the surface portion of the rubber plug body which may be contacted with the transfusible fluid in the container, and a funnel shape air guide member which is formed integrally with the sealing sheet and the upper end of which is extended toward the bottom of the container.

Abstract: A means to connect a hypodermic syringe to its bottle of medicament, so that the syringe is in proper alignment to pierce the bottle sealing diaphragm. The means also holds the syringe to the bottle so that a measured amount of medicament may be withdrawn. Also included are sealing caps to retain full sterility of all elements during use and also non-use. The means permits the entire volume of the medicament to be withdrawn in a plurality of measured doses.

Abstract: In a single-use device for collecting and holding blood samples, provision is made for an evacuated tube with a closure (stopper) that can be pierced by the tip of a needle, the other tip of which is intended to be inserted into a vein of a patient. Disposed below the said pierceable stopper, and in the tube, is a diaphragm intended to passed through by the needle-tip that pierces the stopper, so as to form a supplementar barrier between the interior of the tube and the environment when the pierceable stopper is removed.

Abstract: A port assembly for a container is provided. The port assembly includes an elongated tube extending from an end of a base, the tube defining a tubular bore for receiving a member for accessing the container. The tubular bore includes a membrane for separating the tubular bore into a first portion and second portion, the first portion being closer to the container than the second portion. A resealing injection site is mechanically locked within the second portion of the channel. A method for making the port assembly is also provided.

Abstract: A port and closure assembly is provided. The closure includes a sleeve member and the port a rib member. The sleeve member having an inner circumference that is less than the outer circumference of the rib. The port and closure cooperating to produce an audible signal when the closure is removed from the port.

Abstract: The invention relates to an apparatus for connecting a bottle containing a medicament to a syringe the needle of which is housed in a closed chamber defined by the apparatus and from which the needle can be made to emerge by sliding the separate constituent parts of the appartus along each other. To prevent the needle from emerging from the chamber when no bottle is housed in the appropriate seat provided in the apparatus, there extends from one of the parts of the apparatus an elongated flexible appendix having at least one protuberance which projects into the seat and against which the bottle presses when inserted into the seat, so bending the appendix outwards. In front of the free end of the appendix there is provided a stop tooth projecting from that consituent part of the apparatus which is projecting from that constituent part of the apparatus which is mobile along the first part and extends totally around the seat.

Abstract: A container and needle assembly includes a container body portion having a proximal end, a distal end and a side wall therebetween defining a chamber for retaining fluid and a tip portion extending from the distal end of the body portion having a passageway therethrough. A projection extends outwardly from the tip portion. A pierceable barrier is provided for preventing fluid communication between the chamber and the passageway. A hub having a forward end, a rearward end and a conduit therethrough is movably positioned within the passageway. A first cannula extends outwardly from the forward end of the hub and a second cannula extends outwardly from the rearward end of the hub. A needle shield movably engaging the tip, covers the first cannula. This needle shield has an outer extension portion extending over a portion of the tip which is capable of contacting the projection for limiting the motion of the needle shield toward the proximal end of the body portion.

Abstract: A sterile closure device for a stoppered container which includes a cover member positioned over the top portion of the stopper, a shrinkable band member enclosing a peripheral portion of the cover member and the top portion of the stopper and having a pull tab portion by which the band member can be fractured and a spot of adhesive connecting the peripheral portion of the cover member to the band member such that upon fracture of the band member the cover member and tab portion will be removed together.

Abstract: A vacuum blood-collection tube comprising a tube-shaped vessel having an opening through which air can be removed, and a plug that makes the opening air-tight to maintain low-pressure conditions inside the said vessel, the raw materials of the said vessel being polyethyleneterephthalate, a copolymer of polyethyleneterephthalate, or an acrylonitrile resin, and the inner walls of said vessel incorporating a hydrophilic substance that is either difficult or impossible to dissolve in water and that prevent blood clots from adhering to the inner walls of said tube, a water-soluble substance, and a adsorptive inorganic substance.