Abstract: A port and closure assembly is provided. The closure includes a cap that cooperates with the port to produce a friction fit. The cap and port are hermetically sealed together by a coating. The coating provides a method of determining if the closure has been opened.

Abstract: A storage receptacle sealing and transfer apparatus is disclosed for selectively enabling sealing and transfer of material to and from the receptacle. The apparatus is particularly useful for maintaining and later transferring drug and associated materials, under sterile conditions, to achieve mixing, as, is necessary, for example, in reconstituting a drug by mixing the drug with a diluent prior to delivery to a patient. The transfer apparatus is mounted at the aperture, or mouth, of a storage receptacle to seal the aperture until the contents are needed, and then to permit sterile transfer from one receptacle to another receptacle through a central passage.

Abstract: Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof.Also disclosed is the use of the 5.dbd.-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.

Abstract: A sealing device for bag-shaped, liquid containers for sick-care of flexible material. An opening for filling or emptying the container is sealed by means of a disc-shaped member which has a tube made in one piece therewith and extending in use towards the interior of the container. One end of the tube adjacent the disc-shaped member being closed by a cover which seals against the outside surface of the disc-shaped member level therewith, and the other end of the tube is sealed by means of a flattening of the tube, to produce a sterile space between the two closed ends of the tube, said flattened portion of the tube extending transversely to the longitudinal direction of the tube to form two tube sidewall portions converging towards the flattened portion of the tube, at least one of said sidewall portions being penetrable by a cannula when inserted through the mouth of the tube and extending through the tube.

Abstract: Device for easily and simply coupling to the free end of a small tube (7) mounted on a transfusion needle an apparatus of the type used for coupling a syringe to a drug holding bottle. The device comprises a hollow shaped body (1) that can be coupled to the small tube (7). An axial passageway (13) in the body (1) is closed by a plug (5). A collar (2) shaped as the mouth of a conventional drug bottle projects from the body (1). The collar (2) extends axially and a continuous annular recess (3) is formed therein. The recess (3) has a profile and arrangment sized and shaped to allow for the teeth projecting from the resilient lugs of the apparatus to which the device is to be coupled to be inserted and locked therein.

Abstract: A container having two compartments for keeping two materials in separated relation. When it is desired that the two materials be intermixed, an actuator carrying a pair of piercing pins is inserted into ports of the compartments until membranes blocking exit of the materials from their respective compartment are punctured. When these membranes are punctured the materials are received at a mixing chamber where the materials are mixed.

Abstract: A body is provided with members for coupling it to one end of a bottle or the like. The body has a seat for housing the free end of a syringe, with a hole for allowing for the syringe needle to pass through. The free end of a syringe may be housed and threaded in the seat. On the side opposite surfaces of the body seat and at the syringe end provided for insertion in the seat, there are formed radially projecting longitudinal teeth and slanted resilient fins which are deflected by the teeth as the syringe is threaded to the body. The teeth abut against the fins, thereby preventing the syringe from being screwed off the body.

Abstract: A syringe purging device comprises a closed chamber into which air and/or any excessive amount of a hazardous liquid, such as a chemotherapy drug, is ejected from a syringe to overcome the health hazard created by openly purging syringes into the air or into a pad of gauze material. A sharp open end of a hollow needle of a syringe is sealingly inserted into the chamber and the syringe is activated to purge any air and/or excess liquid into the chamber which expands as necessary. Preferably, the chamber is then further expanded to reduce the pressure therewithin to better ensure clean withdrawal of the needle from the chamber or extension of the needle beyond the chamber and retention within the chamber of any fluids ejected from the syringe.

Abstract: An apparatus comprising a vial container hazardous material in the vial container in a condition requiring a diluent to be mixed therewith to form the liquid solution, and an assemblage carried by the vial container for providing (1) a sealed medicament chamber within the vial container within which the hazardous material is disposed, (2) a filter vented control chamber and (3) a sealed variable volume control chamber between the vented control chamber and the medicament chamber, the arrangement being such as to enable an open end of a syringe needle of a diluent syringe having a syringe chamber containing diluent in communication therewith to be moved into and withdrawn successively from the chambers so as to mix the diluent with the hazardous material in such a way as to substantially prevent the hazardous material from entering the immediate atmospheric environment.

Abstract: A syringe purging device comprises a liquid-tight chamber into which air and/or any excessive amount of a hazardous liquid, such as a chemotherapy drug, is ejected from a syringe to overcome the health hazard created by openly purging syringes into the air or into a pad of gauze material. A sharp open end of a hollow needle of a syringe is sealingly inserted into the liquidtight chamber, and the syringe is activated to purge any air and/or excess liquid into the chamber. The liquidtight chamber may be closed, with any liquid ejected thereinto being retained by absorption into a wad of absorbent material contained within the chamber. Alternately, the chamber may be vented to the atmosphere through a hydrophobic filter such that air injected into the chamber passes through the filter, but any liquid is retained within the chamber since it cannot pass through the hydrophobic filter.

Abstract: A device for sampling blood and measuring erythrocyte sedimentation rate. The device comprises a tube with one end closed, a blood sampling portion on an opened end of the tube and an erythrocyte sedimentation rate measuring portion extending from the blood sampling portion. A stopper is located on the open end of said tube, and may be pierced with a blood drawing needle. Finally a partition member is located within said tube and extends substantially over the entire length of said tube. Blood is directly sampled into the device and the device mixes the sampled blood with a solution of an anticoagulant with a high efficiency in the device. Accordingly, measurement of erythrocyte sedimentation rate can be performed quickly and easily.

Abstract: A valvular system for the extraction and/or addition of liquids held in flexible sterilizable containers of plastic material, including an elastomeric semirigid hydraulic seal having two major superior and inferior faces and at least one minor lateral face. A housing of plastic material for the said elastomeric element. The valvular system is characterized in that at least one of the said major faces of the elastomeric element is at least partially spaced from the housing body.

Abstract: A guide member is adapted to be removably mounted in the access aperture of a capped vial and arranged to guide and to support a delicate syringe needle as the same is advanced through a resilient septum closing the vial.

Abstract: Device for ventilating and pressure balancing the interior of a sealed vessel (91) containing a substance which is to be taken out from said vessel e.g. by an injection syringe, said vessel being provided with a closure means (2) comprising a sealing member (2) through which a puncturing member, e.g. a needle can be passed for entering the interior of said vessel the closure means (2) or a connection means (3) attachable onto said vessel is provided with ventilating means (10, 13, 14, 15) arranged to provide a communication between the interior of the vessel (1) and a closed container or alternatively the atmosphere via a filter (16).

Abstract: A medicinal vial cover for preventing the introduction of a liquid solution to atmosphere during the removal of the solution from a container of the type having an axially-extending neck and an entrance opening coaxial with the neck in which the opening is sealed by a rubber plug through which a hypodermic needle is inserted to extract the solution into a syringe, the cover having a tip at one of its ends and a hollow base at its other end adapted to be attached over the neck of the container. A hypodermic needle can then be inserted through both the cover and the rubber plug to withdraw the solution into a syringe with any aerosol or droplets being trapped within the cover.

Abstract: A nonvented gravity fed exponential mixing and delivery system and apparatus for the administration of a drug in a precalculated manner to give constant therapeutic blood plasma levels in the recipient, (patient), which provides an inexpensive, quick and simple exponential mixing procedure to deliver an infusion containing exponentially decreasing concentrations of a drug, which the exponential mixing of a dilute solution of the drug or isotonic solution which flows by gravity from a conventional IV container, through a coupling means, into a vertically aligned nonvented nondeformable mixing chamber, filled to capacity with a concentrated solution of said drug, said mixing container being provided with a verticle inlet conduit means and a vertical outlet conduit means at opposing ends, each conduit means extending into said mixing container at a height to provide a sufficient height differential to induce exponential mixing of the solutions, to effect an exponentially decreasing concentration of said drug dur

Abstract: A plug assembly for puncture has a cylindrical member of a rigid resin having first and second openings one at each end thereof and a channel for communication between the first and second openings. The cylindrical member has a mating tapering surface on an outer side of the first opening. The assembly also includes an elastic member of a synthetic resin arranged at least in the channel extending toward the second opening of the cylindrical member so as to block the channel of the cylindrical member. The elastic member permits a needle penetration and assuring a re-sealability after an injection needle has been withdrawn. The cylindrical member and the elastic member are molded in an integral fashion.

Abstract: A fitment for attachment to a container having an integral body constructed from a thermoplastic foam and having an integral skin outer surface and a cellular core. The body has a top and bottom surface and includes at least one resealable port.

Abstract: A penetrator for fully draining the liquid in multi-dose vials when drawing liquid into a syringe is disclosed. The apparatus also provides a cuff and a sleeve that are encoded for preventing misidentification of the contents of a syringe by identifying the syringe with the vial from which the contents of the syringe were drawn. The cuff is mounted on the penetrator and the sleeve is mounted on the port end of the syringe, so that a mismatch between the cuff and sleeve is readily detected when the port end of the syringe is attached to the penetrator to withdraw liquid from the vial.

Abstract: A container comprises a bottle for a liquid product and having at the end of its neck a leakproof envelope enclosing an additional product to be stored separately from the liquid in the bottle. A cap on the neck includes a slidable push button carrying a perforator to open the envelope in a central region of the envelope to allow the additional product to mix with the liquid and then to be discharged through an eccentric duct in the cap rather than having to pass through the center of the cap where the perforator is positioned.

Abstract: An improved disposable liquid container adapted for infant nursing is provided for maintaining nursing liquid in a sterile or aseptic condition until dispensed therefrom. Rigid penetrating means carried by a semirigid support member penetrate a compartment closing diaphragm to allow nursing liquid to flow from the compartment to a communicating, attached nipple. The semirigid support member is integral with the liquid compartment and substantially preserves its shape as the fluid is dispensed therefrom. Flexible walls of the container are allowed to collapse together as the fluid is dispensed to prevent excessive ingestion of air by a nursing infant. The attached nipple is maintained in a clean, uncontaminated, sterile, or aseptic condition until use by means of separable sealing tabs or a discardable cover.

Abstract: A coupling member is disclosed for use in connecting together flexible tubes and the like. The coupling member is adapted for connection with a mating coupling member, and includes an outer rigid coupling component which is thermally resistant and an inner coupling component which is thin and flexible, so that the inner coupling component can provide a penetrable seal and whereby the overall coupling member is capable of withstanding autoclaving temperatures so that it can be sterilized prior to use. A coupling device including such a coupling member is also disclosed, including a second coupling member which is capable of mating with the first coupling member and which includes a penetrating portion so that when the two coupling members are mated, the penetrating portion of the second coupling member penetrates the inner coupling component of the first coupling member.

Abstract: A pierceable port for injecting or withdrawing a fluid through a hollow needle inserted into a container. The port has a covering film securing a sterile pad of resealable material to a wall of the container having a portion pierceable by a needle. A tear strip is heat welded to the cover so as to form a removable tab comprised of a welded tear strip section, a welded cover section and an unwelded lap forming a grip for removing the tab. The tab is connected to an unwelded portion of the cover by a tear joint of substantially less tear strength than either the tab or the unwelded cover portion. The cover and the base member define a chamber for maintaining the sterility of the pad until the tab is removed to expose a sterile portion of the pad for insertion of the needle. A method for making the port is described.

Abstract: The present invention comprehends the provision of a fluid tight holding chamber which accumulates solution (1) from the vial that aspirates or is pressured out of the vial upon extraction of the cannula from the vial or (2) is aspirated from the syringe before the cannula is removed from the holding chamber. The holding chamber is defined in the neck of the vial by an insert. The insert may be one piece or two piece and has an inner end sealing the contents of the vial from the holding chamber and an outer end sealing the aspirated medicament in the holding chamber. The insert has a luer seal for sealing against the luer connector on the syringe during the practice of certain procedures.

Abstract: A self-contained body mounted pump assembly for continuously administering a therapeutic agent parenterally. The pump has a transparent top through which the contents can be seen and outwardly flaring sides to provide for comfort, stability and other useful features. The pump assembly is driven by a fluid imbibing, preferably osmotic pump and contains its own source of actuating fluid. Means for superimposing a pulse dose on the tonic flow are also described.

Abstract: A stoppered vial containing a medicament is secured through the edge of a flexible container. Mixing of the medicament in the vial with the contents of the flexible container is accomplished by removing the stopper from the vial by manipulation through the sides of the flexible container. In one embodiment, the stoppered vial is mounted through and in the edge of the flexible container and in another embodiment the flexible container has a port which will receive the stoppered vial therein in a secure manner.

Abstract: A reconstitution device for constituting a drug in a standard drug vial with a liquid in a second container such as a parenteral solution container is provided. The reconstitution device 10 includes a housing 52 and a hollow, double-pointed needle 54 mounted within the housing. The housing includes a sheath 70 having a substantially circular base 72 and a skirt 74 depending from the base. The skirt 72 includes a free end 76, a substantially cylindrical inner surface 78 and an outer surface 80. A plurality of inwardly projecting bumps 82 are intermittently spaced about the inner surface 78. The bumps are disposed a substantially equal distance from the base 72, the distance being substantially equal to the width of the malleable band.

Abstract: An injector for infusion or transfusion systems utilizes a housing having a duct extending longitudinally therethrough. The inner surface of a penetrable membrane covers an end of the duct, with the edge of the surface abutting an annular shoulder of the housing. A ring is disposed in an annular indentation on the periphery of the outer surface of the membrane, with the outer edge of the inner surface of the ring abutting a second annular shoulder of the housing. The outer surface of the ring and the central portion of the outer surface of the membrane are flush.

Abstract: An arrangement in apparatus for preparing solutions from dry harmful materials, such as cytostaticum, radioactive, toxic and allergy-producing substances, includes a glass ampoule (1) for accommodating the dry substance. The ampoule communicates with a device (4) for enlarging the internal volume of the ampoule, so as to equalize the pressure generated therein when preparing the solution.Solvent is introduced into the ampoule (1) and solution removed therefrom through a cannula (8) which is constantly sheathed against contamination by means of an elastic sheath (10). The sheath is provided with self-sealing means (11) arranged to sealingly abut the ampoule (1) when withdrawing solution therefrom, in a manner to tightly seal the ampoule against the surroundings.

Abstract: A container suitable for storing and dispensing parenteral fluids comprises a flat member 2 inserted into a pouch 1 of plastics material. The member has two ports 9, 10 passing therethrough which are protected by removeable tabs 14, 15 having passageways 19, 20 which are coaxial with the ports. The port 9 is sealed after filling by a cup-shaped closure (25, FIG. 4 not shown). The port 10 is closed by a ruptureable membrane and may have a resilient plug (29, FIG. 5 not shown) and needle guide (30, FIG. 5 not shown). The tabs may be connected to the member by portions 16, 16a, 17, 17a and 18 of reduced thickness. The outer ends of the passageways are sealed by covers 21, 22 or by flattening and sealing the ends of the passageways.The member, ports and tabs may be integrally formed by injection moulding (FIG. 1).

Abstract: A medical solution container having an outlet port with a neck that includes a tapered annular collar for slidably and sealingly engaging the hollow spike of an administration set. The inner and outer surfaces of the tapered collar slope inwardly, the collar defining an opening that is smaller (when the collar is unstretched) than the reduced portion of the bore of the neck communicating with that collar, thereby helping to assure effective contact between the collar and an inserted spike.

Abstract: A mixing and dispensing receptacle including a first container defining a first nozzle portion and a first sealed chamber retaining a first substance and a rupturable wall portion separating the first chamber from the interior of the first nozzle portion; and a second container defining a second chamber retaining a second substance and a second nozzle portion disposed at least partially within the interior of the first nozzle portion and circumferentially sealed thereto so as to sealingly isolate the second substance. The second nozzle portion is movable axially relative to the first nozzle portion so as to pierce the rupturable wall portion and provide communication between the first and second chambers. One of the nozzle portions comprises a tapered outer surface adapted for engagement with a mating coupling member and an aseptic shield covers the tapered outer surface and is removable therefrom.

Abstract: A closed pouch for infusion liquid is made from a continuously extruded plastics hose by providing transverse seals and cutting the hose in said seals, and an assembly of two necks and a filling hose connection is secured to the outer wall of each pouch, said wall being pierced when liquid is to be extracted from or supplied to the pouch through one of said necks. Such an assembly is made from plastics as a unitary structure together with closing caps for the necks and a common flange to be secured to said wall. One neck is provided, at the flange side, with an enlarged bore terminating in a shoulder which is substantially parallel to the flange, and a pierceable sealing pad is inserted from the flange side into said enlarged bore, the latter being eventually closed by the pouch wall.

Abstract: A port system for a blow molded intravenous solution container in which microbial contamination is prevented upon administration of the solution. The port system includes an integrally formed tube projecting outwardly from the container with a pierceable diaphragm positioned over the entry portion of the tube. Preferably, with respect to the tube entry portion, the diaphragm is concave, and may be made thinner in the center to facilitate proper placement of a piercing pin. In one embodiment, the port tube is inwardly flared adjacent the diaphragm so that as the piercing element is pushed through the diaphragm, the remnants of the pierced diaphragm can be pressed into the flared portion of the tube.

Abstract: The invention relates to an assembly for preparing and dispensing a solution and to the stopper for such an assembly, said assembly comprising a first bottle containing a first liquid component, with an elongated head; a second bottle containing a second component, liquid or solid; a stopper for this second bottle presenting a recess whose shape is homologous of the head of the first bottle, and in which said head is for example screwed. The bottom of the recess is constituted by a membrane of deformable material comprising an axial orifice which is hermetically closed, in the absence of deformation of the membrane, by the natural radial constriction of the material of the membrane. By screwing the first bottle in the stopper, the membrane is axially deformed and the orifice is radially distended, thus allowing the two bottles to be placed in communication in reversible manner. The invention also relates to a process for making the stopper.

Abstract: A bag for storing liquids for medical purposes such as blood and liquids for parenteral administration and which has neutral physiological properties is made of polyolefin material that is more specially in the form of a polyethylene film for the body of the bag and a copolymer of ethylene and vinyl acetate, with more specially 20 to 32% by weight of vinyl acetate, as a material for the hose connector. The copolymer is welded to the material of the body of the bag and then cross linked.

Abstract: Disclosed is a uniquely simple, multiple use apparatus for the packaging of fluids, such as those reference fluids used for the calibration and standardization of blood gas instrumentation, which must not be exposed to air.

Abstract: A pouch-like bag for containing a liquid for medical or surgical use has two walls (10, 11) formed by respective plies of flexible plastics material sealed together (at 12) around at least their top and side edges and one or more, folded plies (14) of flexible plastics material of substantially smaller dimensions forming a gusset bottom portion having opposed leaves (16, 17) each of which is sealed (at 18) to the adjacent wall (10, 11). The gusset ply (14) carries one or more elements (21, 22 ) of elastomeric material capable of making an hermetic and liquid-tight seal with a needle, e.g. an administration set needle for a hospital drip-feed system or a hypodermic or injection needle for injecting a drug into the bag contents.

Abstract: A bottle containing injection liquid from which liquid is intended to be withdrawn by inserting a hollow needle into the bottle is provided with a fitment for sterilizing the needle as it is introduced into the bottle. The fitment comprises connector attached to the bottle and a detachable cap having a body part which is received within a tubular part of the connector. The cap is in the form of an enclosure containing a body of absorbent material impregnated with sterilizing substance and incorporating an end wall having an integral removable portion separable therefrom by rupturing the material of the end wall so as to form an aperture in the end wall through which the point of the needle may pass into the enclosure. The point of the needle is thereby sterilized as it is moved through the enclosure into the bottle to withdraw liquid therefrom and is sterilized for a second time on withdrawal from the fitment.

Abstract: A closure device for fluid-tight closure of an opening of a fluid container. The device comprises a casing part (1) and a cap part (2). These parts are injection molded from different plastic materials, preferably from PVC and polypropylene, respectively, one partially against the other. A tubular portion (12) of the cap part (2) intrudes sealingly into a substantially cylindrical hollow space between an internal and an external sleeve portion (3,4) of the casing part (1).

Abstract: A port structure is provided for a container such as a flexible bag for I.V. fluids which will permit the piercing by a piercing pin in a leak resistant manner. The port structure is fabricated with the usual piercing diaphragm positioned in the innermost portion of the tubular port. Unlike the usual construction of port structures of this type, the inner tubular member containing the pierceable diaphragm is not connected to the remaining portions of the port structure at the outermost regions thereof or adjacent the flange or connecting portions, but instead joins the tubular member at an intermediary position so as to create a standing port for receiving the piercing pin.

Abstract: A thermoplastic container is shown having an insert sealing the container. The insert includes a membrane which can be pierced to provide access to the inside of the container to draw off a substance such as a sterile liquid. The insert is held by a retaining structure which receives and seals with the insert.

Abstract: The invention relates to a storage bag, in particular for medical purposes for storing blood or infusion solutions, comprising a thermoplastic polymer material and having at least one outlet comprising a tube member.

Abstract: A container for liquids for use in medicine and surgery is made of flexible plastics material and a container volume is defined by heat seals at each end of the container. At one end of the container there are three ports one being a filling tube and the other two being outlet or additive ports which are sealed by frangible membranes. To allow for expansion of air in the volumes outside those membranes the outer end of each of those ports open into expansion chambers defined by further heat sealed seams of the sheet or tube material forming the container. A line of weakening enables these expansion chambers to be torn off immediately before the use of the appropriate port so as to gain access to the port but so as meanwhile to have preserved the sterility of the outer surface of the membrane.

Abstract: Improved port and closure constructions are disclosed for medical solution containers, particularly collapsible containers intended for storing and administering parenteral solutions. An outlet port includes a tubular neck with an elastomeric sealing disc held against the distal end of the neck by a tear-off cap, the disc having planar surfaces and a circumferential rib spaced from each of those surfaces for sealingly engaging the inside of the cap. Within the outlet port is an annular collar that slopes and tapers distally inwardly for engaging the spike of an administration set. An inlet port is also provided, such inlet port having a neck with an internal annular distally-facing shoulder and a plurality of longitudinal internal ribs located distal to the shoulder. The ribs are useful for guiding a stopper into sealing engagement with the shoulder without interfering with the seal as so formed.

Abstract: Film material for use in sterilized medical solution containers such as blood bags or I.V. bags, comprising 30-90% linear low density polyethylene (LLDPE) and 10-70% styrene-ethylene-butylene-styrene (SEBS). The particular LLDPE and SEBS materials are selected from among known LLDPE and SEBS materials according to density, in the case of LLDPE, and styrene/rubber ratio and composition in the case of SEBS. Up to 10% of an optional third component such as high melt index LLDPE or polypropylene may be added as a processing aid. Material having greater than 50% LLDPE is particularly well suited for medical solution container application.

Abstract: A method of preparation of valves for a flat, flexible, sterilizable container capable of sterilely containing a liquid to be removed under absolutely sterile conditions which comprises the steps of:forming a two-layer laminate including a first layer of a copolymer of ethylene with a minor proportion of butylene and a second layer of an amide polymer; forming a pocket in the two-layer laminate wherein the first layer forms the inner surface of the pocket; providing an elastomeric core element having spaced major faces; inserting the core element into the pocket in the two-layer laminate; providing a three-layer laminate including a first outer layer of a major portion of a propylene polymer, a second outer layer of a copolymer of ethylene with a minor proportion of butylene, and an intermediate layer of an amide polymer; orienting the three-layer laminate so that the second outer layer thereof is apposed to the first layer of the two-layer laminate; expelling air surrounding the core element in the pocket; w

Abstract: A composite closure arrangement is provided for blood sample collection tubes, and particularly evacuated blood collection tubes for reducing exposure of a technician to any blood droplets or blood aerosol during removal of a sample of the blood from the container. The device also hides and contains any such aerosol or droplets. Moreover, the device provides enhanced ease of removal of the stopper, when desired. A cap is configured to be placed over and fitted onto the rubber stopper of the tube, with the top portion of the cap extending over and spaced from the top of the stopper to define a cavity between the overlying portion of the cap and the top of the stopper. The center of the overlapping portion of the cap includes a sample needle access bore providing access to the stopper diaphragm. Cooperating opposed abutments on the cap and the stopper maintain the cap on the stopper.

Abstract: A thermoplastic container, particularly a bottle, has a one-piece container top unitarily formed with the container body and a container neck and enclosing a stopper of elastomeric material, particularly rubber. To prevent contact between the container contents and the stopper, a mounting and separating element is provided between the stopper and the container. The mounting element has tubular axially extending plug and retaining portions and has one edge which can be welded to the container and a radially projecting, thin weld ring.

Abstract: A catheter plug for sealing the proximal end of a parenterally placed catheter and permitting repeated small volume injections and delivery of parenteral fluids without disturbing the sterility of the catheter. The catheter plug has a compression chamber for applying compression to a self-sealing elastometric septum thereby enhancing the septum's self-sealing characteristics. Compression force is applied to the septum by screw movement between oppositely threaded male and female couplers. The catheter plug is particularly useful in situations where pressures higher than arterial pressures are encountered or where it is desirable to leave the catheter indwelling for long periods of time.