Implanted Dynamic Device Or System Patents (Class 604/891.1)
  • Patent number: 10313420
    Abstract: A system includes a portable device and an external device connected wirelessly. Graphical user interface data determines a user interface functionality to be executed in a user interface of the external device in the portable apparatus, and is transmitted to the external device. The user interface functionality includes presenting at least one graphical interaction element on the user interface and receiving user input as a response to the user interacting with the graphical interaction element. The input data received from the user interface is used in the portable device to control a computer process relating to physiological data.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: June 4, 2019
    Assignee: Polar Electro OY
    Inventors: Niclas Granqvist, Mika Erkkila, Olli Komulainen
  • Patent number: 10292831
    Abstract: A system and method for electrical stimulation in an orthopedic implant that includes at least one implantable component with an implant body, a plurality of electrodes, and implant circuitry is effective to convert an external wireless power transmission to an electrical current and effective to control the plurality of electrodes; and at least one non-implant with a power source, and transmitter circuitry to generate the electromagnetic field that couples with the implant circuitry.
    Type: Grant
    Filed: March 19, 2016
    Date of Patent: May 21, 2019
    Assignee: INTELLIGENT IMPLANTS LIMITED
    Inventors: Erik Zellmer, Rory Murphy
  • Patent number: 10264972
    Abstract: A mechanism is provided. The mechanism includes a user device and a smart pill within a host. The smart pill is communicatively connected to the user device for transmitting and receiving secure communications. Settings of the smart pill while in the host are configured to be changed based on patient category data of the host.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: April 23, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James R. Kozloski, Clifford A. Pickover
  • Patent number: 10251553
    Abstract: A mechanism is provided. The mechanism includes a user device and a smart pill within a host. The smart pill is communicatively connected to the user device for transmitting and receiving secure communications. Settings of the smart pill while in the host are configured to be changed based on patient category data of the host.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: April 9, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James R. Kozloski, Clifford A. Pickover
  • Patent number: 10226587
    Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 12, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry B. Gray, Russell H. Beavis
  • Patent number: 10143770
    Abstract: The present invention relates to a photocatalytic apparatus and a heating, ventilating, and air conditioning (HVAC) equipment for a vehicle comprising the same and, more specifically, to a photocatalytic apparatus and HVAC equipment for a vehicle comprising the same, wherein the photocatalytic apparatus may sterilize and deodorize an evaporator in addition to purifying air introduced into an HVAC case and may continuously maintain sterilization and deodorization functions by efficiently radiating heat generated from the photocatalytic apparatus.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: December 4, 2018
    Assignee: HANON SYSTEMS
    Inventors: Jae Ho Kim, Ki Hong Kim, Ji-Yong Park, Tae Yong Park, Yong Jun Jee
  • Patent number: 10130757
    Abstract: A medical therapy system including liquid detection is disclosed. A medical therapy includes a case with an interior and an exterior. Within the interior of the case is the liquid detection system that includes a first electrode set with a first positive electrode and a first negative electrode. The liquid detection system further includes an impedance measurement circuit coupled to the first electrode set to determine impedance values between the first positive electrode and the first negative electrode. A threshold detector compares impedance values between the first electrode set to a first threshold impedance. A microprocessor is programmed to initiate an alarm when measured impedance from the first electrode set is below the first threshold impedance.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: November 20, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Yongbo Wang, Steve Chow
  • Patent number: 10123981
    Abstract: Methods, systems, devices, and medicaments are provided for locally administering to a pelvic-area organ or tissue structure in a patient at least one drug continuously or continually over a treatment period of 24 hours or more in an amount effective to achieve a therapeutic effect in another organ or tissue structure by means of shared or convergent pelvic afferent pathways. The methods systems, devices, and medicaments can be used in the treatment of IC/BPS, chronic pelvic pain, vulvodynia, orchialgia, urethral syndrome, dysparenia, chronic prostatitis, chronic pelvic pain, levator ani syndrome, irritative bowel syndrome, or a combination thereof. The drug may include anesthetic agents, analgesic agents, antispasmodic agents, antimuscarinic agents, and combinations thereof. The drug may be released from a drug delivery device or a sustained release composition deployed inside the bladder.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 13, 2018
    Assignee: ALLERGAN, INC.
    Inventors: Julie Himes, Dennis Giesing, Cheryl Larrivee-Elkins, Michael J. Cima, Purnanand Sarma, Paul Goldenheim
  • Patent number: 10105317
    Abstract: A drug delivery method for effective drug application is disclosed in this invention. In this method, a micro-carrier delivers an encapsulated, desired drug directly to targeted sites without significant interactions with other components in the biological system in the pathway. In one embodiment, a micro-carrier containing encapsulated drug is first delivered to the general area for treatment. It then scans the area and selectively attaches itself the cell site or organ location to be treated. Finally, the desired drug contained in the micro-carrier is released to the attached cell or organ. In another embodiment, a micro-device is first used to process the general area to be treated to enhance differentiation in properties (such as surface charge) between healthy cells and unhealthy cells (such as cancer cells). Drug encapsulated in the micro-carrier is next applied to preferentially attach onto the targeted sites (such as cancer cell sites) to be treated.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: October 23, 2018
    Assignee: Anpac Bio-Medical Science Co., Ltd.
    Inventors: Chris C. Yu, He Yu
  • Patent number: 10105093
    Abstract: A device comprising: means for obtaining a parameter of a sample of body fluid from a user; means for using information provided by one or more sensors to calculate a measure of physical activity of the user; means for calculating a medicament dose using at least in part the measured parameter and the measure of physical activity of the user; and means for indicating the calculated medicament dose to the user.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: October 23, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Schabbach, Jörg Heisiep, Stephan Müller-Pathle, Ross MacArthur
  • Patent number: 10098765
    Abstract: The present invention relates to an implant (10), and particularly to an intraluminal endoprosthesis, comprising a body and at least one abluminal layer (3) disposed on the body, the abluminal layer preferably containing at least one pharmaceutically active substance. In order to protect the abluminal layer (3) from delamination or shearing, the abluminal layer (3) is additionally fastened to the implant body at least in a transition region (7) by way of at least one anchoring layer (5) disposed on the abluminal layer (3). In addition, methods for producing such an implant are described.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: October 16, 2018
    Assignee: BIOTRONIK AG
    Inventors: Bjoern Klocke, Alexander Borck
  • Patent number: 10092387
    Abstract: An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 9, 2018
    Assignees: California Institute of Technology, City of Hope
    Inventors: Yu-Chong Tai, Dongyang Kang, Hirotake Komatsu, Henry K. Lin, Yoko Mullen
  • Patent number: 10085828
    Abstract: Apparatus is provided, including a housing configured for insertion into a body of a subject; at least one oxygen reservoir disposed within the housing; and at least one layer of transplanted cells, disposed within the housing; and gaseous oxygen disposed within the at least one oxygen reservoir. Other embodiments are also described.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: October 2, 2018
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Yaki Stern, Yoram Rozy
  • Patent number: 10076324
    Abstract: Adjunct material to provide controlled drug elution is provided. In general, an implantable adjunct formed from at least one bioabsorbable polymer can be configured to be applied to tissue by a surgical stapler in conjunction with staples. The adjunct can be made from a plurality of fibers and it can have one or more medicants releasably retained therein that are effective to provide a desired effect on tissue in-growth in a predetermined manner. Release of each of the at least one medicants from the adjunct material can be controlled by a degradation rate of the at least one bioabsorbable polymer.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: September 18, 2018
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Michael J. Vendely, Frederick E. Shelton, IV
  • Patent number: 10039864
    Abstract: The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 7, 2018
    Assignee: Interface Biologics, Inc.
    Inventors: Roseita Esfand, J. Paul Santerre, Mark J. Ernsting, H. Hung Pham, Vivian Z. Wang, Meilin Yang
  • Patent number: 9981137
    Abstract: An implantable medical device that includes electrical circuitry for providing a therapy to a patient. The device also includes a housing forming an inner chamber that is adapted for receiving, at least a portion of the electrical circuitry. The device further includes a thermally conductive material that is configured to disperse heat from a first portion of the implantable medical device that is located in proximity to a heat generating component of the electrical circuitry, to a second portion of the implantable medical device that is not located in proximity to said heat generating component. The thermally conductive material is a discrete component separate from the electrical circuitry and the housing.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 29, 2018
    Assignee: Nuvectra Corporation
    Inventor: Jay H Eiger
  • Patent number: 9950151
    Abstract: An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: April 24, 2018
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Avi Rotem, Uriel Barkai, Baruch Zimerman, Zohar Gendler
  • Patent number: 9919099
    Abstract: Implanted drug pump devices can be refilled via a fill port in the drug reservoir that includes a self-resealable septum.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 20, 2018
    Assignee: MINIPUMPS, LLC
    Inventors: Yu-Chong Tai, Jason Shih, Julian D. Kavazov
  • Patent number: 9810688
    Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 7, 2017
    Assignee: ROBERT BOSCH GMBH
    Inventors: Nadezda Fomina, Christopher Johnson, Sam Kavusi, Habib Ahmad
  • Patent number: 9782430
    Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10 % by weight to 20 % by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: October 10, 2017
    Assignee: Covidien LP
    Inventors: Rachit Ohri, Phillip D. Blaskovich
  • Patent number: 9770556
    Abstract: Methods and apparatus for translating a continuous-delivery delivery profile into a plurality of periodic bolus deliveries.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: September 26, 2017
    Assignee: Medallion Therapeutics, Inc.
    Inventors: Brian M. Shelton, Pedrum Minaie, Jon Douglas Newbill, Peter C. Lord
  • Patent number: 9764087
    Abstract: Systems for predicting a drug delivery profile as described herein include at least one drug pump and/or a controllable valve that produce a drug flow and dispense at least a first drug. The system also includes at least one carrier fluid pump and/or another controllable valve that produces a carrier fluid flow, a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow, and a fluid path for carrying the mixed flow between the flow junction structure and a delivery point. The system further includes a processing device configured to predict the drug delivery profile at the delivery point based on determining a predicted time variation of drug concentration at the delivery point using at least a model of the mixed flow. The model includes a plurality of parameters related to propagation of the mixed flow through the fluid path.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 19, 2017
    Assignees: The General Hospital Corporation, Steward St. Elizabeth's Medical Center of Boston, Inc.
    Inventors: Robert A. Peterfreund, Michael Parker, Nathaniel M. Sims, Mark A. Lovich, Harold J. DeMonaco
  • Patent number: 9717845
    Abstract: A medical therapy system for delivering at least two therapies based on a geographic location of the medical therapy system is disclosed. The medical therapy system includes an infusion pump having a case that contains a processor, memory, a drive mechanism, a reservoir, a radio, and a sensor suite. The sensor suite includes a global positioning system (GPS) receiver to determine a location of the infusion pump. The processor receives the location of the infusion pump and executes first instructions stored in the memory. The processor executes second instructions stored in the memory only when the location of the infusion pump is within a safe zone defined around specified GPS coordinates.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: August 1, 2017
    Assignee: MEDTRONIC MINIMED, INC.
    Inventor: Emilian Istoc
  • Patent number: 9687638
    Abstract: The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: June 27, 2017
    Assignee: Medimetrics Personalized Drug Delivery
    Inventors: Hans Zou, Jeff Shimizu
  • Patent number: 9610429
    Abstract: Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: April 4, 2017
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Jason L. Harris, Taylor W. Aronhalt, Dwight Henninger, James W. Voegele, Lee M. Kaplan, Nicholas Stylopoulos
  • Patent number: 9603997
    Abstract: Implanted drug pump devices can be refilled with a refill needle inserted through a fill port in the drug reservoir of the drug pump device. Proper needle insertion may be verified visually or using electrical, magnetic, optical, acoustic, or other suitable sensing mechanisms.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 28, 2017
    Assignee: MINIPUMPS, LLC
    Inventors: Mark Humayun, Yu-Chong Tai, Nenad Jelisavcic, Julian D. Kavazov, Fukang Jiang
  • Patent number: 9533133
    Abstract: A venous access port assembly having a base, a peripheral surface, and a septum. The base defines an interior reservoir. The peripheral surface includes integrally molded X-ray discernable indicia identifying that the assembly is rated for power injection. The X-ray discernable indicia may extend through a height of the peripheral surface from a top surface to a bottom surface thereof. According to one aspect, the peripheral surface may be formed from X-ray discernable material, and the X-ray discernable indicia may be formed from the X-ray discernable material, or they may be formed by voids in the X-ray discernable material. According to another aspect, the peripheral surface may be formed from a radiotransparent or radiolucent material and applied with a radiopaque agent, and the X-ray discernable indicia may be one or more voids in the radiopaque agent or may be portions of the peripheral surface applied with the radiopaque agent.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: January 3, 2017
    Assignee: Medical Components, Inc.
    Inventors: Timothy M. Schweikert, Raymond R. Bizup, Kevin E. Sanford, Kenneth M. Zinn
  • Patent number: 9532705
    Abstract: In a method and a system for contact-free magnetic navigation of a magnetic body in a work space that is at least partially filled with a fluid, a thickening agent is added to the fluid. The use of a thickening agent as an additive for such a fluid is also described.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: January 3, 2017
    Assignee: Siemens Aktiengesellschaft
    Inventors: Stefan Foertsch, Henrik Keller
  • Patent number: 9504787
    Abstract: An ambulatory infusion device for the infusion of a liquid drug into a patient's body over an extended time period includes an infusion cannula designed to be placed in the patient's subcutaneous tissue. At least two subcutaneous electrodes are comprised by the infusion cannula and are placed in the subcutaneous tissue. An impedance measuring unit is operatively coupled to the at least two electrodes and is configured to measure at least one impedance value between the at least two electrodes. A variation of the at least one impedance value reflects a displacement of interstitial fluid by drug upon drug administration. An event trigger unit is operatively coupled to the impedance measuring unit and being configured to evaluate the at least one impedance value and to generate an event trigger if evaluation of the at least one impedance value indicates the occurrence of an administration anomaly.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: November 29, 2016
    Assignee: Roche Diagnostics International AG
    Inventors: Reto Aeschilimann, James Leuenberger
  • Patent number: 9474712
    Abstract: Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: October 25, 2016
    Assignee: Gearbox, LLC
    Inventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9456916
    Abstract: This invention is a device and method for selectively and automatically reducing absorption of unhealthy food in a person's gastrointestinal tract, while allowing normal absorption of healthy food. In an example, such a device can comprise: a food-identifying sensor; an absorption-reducing substance; an implanted reservoir; and a release-control mechanism that selectively and automatically releases the substance into the person's gastrointestinal tract when the sensor detects that the person is consuming unhealthy food.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: October 4, 2016
    Assignee: Medibotics LLC
    Inventor: Robert A. Connor
  • Patent number: 9440003
    Abstract: According to an aspect of the present invention, various medical devices, including implantable or insertable medical devices, are provided, which comprise at least one particle-containing region whose surface is at least partially coated with a diamond-like coating.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: September 13, 2016
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventor: Jan Weber
  • Patent number: 9421311
    Abstract: A catheter pump is disclosed herein. The catheter pump can include a catheter assembly that comprises a drive shaft and an impeller coupled to a distal end of the drive shaft. A driven assembly can be coupled to a proximal end of the drive shaft within a driven assembly housing. The catheter pump can also include a drive system that comprises a motor and a drive magnet coupled to an output shaft of the motor. The drive system can include a drive assembly housing having at least one magnet therein. Further, a securement device can be configured to prevent disengagement of the driven assembly housing from the drive assembly housing during operation of the pump.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: August 23, 2016
    Assignee: THORATEC CORPORATION
    Inventors: Adam R. Tanner, Richard L. Keenan, Doug M. Messner, Michael R. Butler
  • Patent number: 9414930
    Abstract: Effective devices and methods using a chemonucleolysis agent are provided for treating an intervertebral disc or treating spinal arachnoiditis. The devices and methods comprise a chemonucleolysis agent to degrade or to shrink at least a portion of the intervertebral disc. In some embodiments, the methods and devices are configured to immediately release an effective amount of the chemonucleolysis agent within 24 hours when the device comes in contact directly or indirectly with an activator and provide sustained release of the chemonucleolysis agent over a period of up to one year to treat the intervertebral disc. In some embodiments, the chemonucleolysis agent in the device is administered in or near the intrathecal space and/or thecal sac to treat spinal arachnoiditis.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: August 16, 2016
    Assignee: KYPHON SÀRL
    Inventor: Elaine Lee
  • Patent number: 9416791
    Abstract: To design the rotor as compressible in the radial direction in a fluid pump, in particular for microinvasive medical use, said rotor is configured as stretchable in its longitudinal direction by push elements and pull elements acting axially on it. A fluid pump is presented herein having a drivable rotor which is rotatable about its longitudinal axis and which has at least one impeller blade. The rotor at least partly comprises an elastically compressible and expandable material and is elastically stretchable by elements acting axially on it in the direction of its longitudinal axis. A push element and a pull element engage at different ends of the rotor and/or of a housing of the fluid pump. The push element and the pull element are configured to apply tension to the rotor by applying force in mutually opposite directions at the different ends of the rotor.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: August 16, 2016
    Assignee: ECP ENTWICKLUNGSGESELLSCHAFT MBH
    Inventor: Thomas Toellner
  • Patent number: 9386925
    Abstract: The invention relates to a device for drug administration and/or monitoring the status of a patient, the device comprising a first and a second measuring means, and the time for using the second measuring means being set in accordance with the data of the first measuring means.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: July 12, 2016
    Assignee: Medimetrics Personalized Drug Delivery B.V.
    Inventors: Henrike Krijnsen, Geert Langereis, Michel Van Bruggen, Ventzeslav Iordanov
  • Patent number: 9387163
    Abstract: Methods, systems, devices, and medicaments are provided for locally administering to a pelvic-area organ or tissue structure in a patient at least one drug continuously or continually over a treatment period of 24 hours or more in an amount effective to achieve a therapeutic effect in another organ or tissue structure by means of shared or convergent pelvic afferent pathways. The methods systems, devices, and medicaments can be used in the treatment of IC/BPS, chronic pelvic pain, vulvodynia, orchialgia, urethral syndrome, dysparenia, chronic prostatitis, chronic pelvic pain, levator ani syndrome, irritative bowel syndrome, or a combination thereof. The drug may include anesthetic agents, analgesic agents, antispasmodic agents, antimuscarinic agents, and combinations thereof. The drug may be released from a drug delivery device or a sustained release composition deployed inside the bladder.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: July 12, 2016
    Assignee: Allergan, Inc.
    Inventors: Julie Himes, Dennis Giesing, Cheryl Larrivee-Elkins, Michael J. Cima, Purnanand Sarma, Paul Goldenheim
  • Patent number: 9375582
    Abstract: The present disclosure involves an electronic apparatus for programming an implantable medical device to provide a stimulation therapy for a patient. The electronic apparatus includes a user interface configured to communicate with a user, a memory storage configured to store executable instructions, and a computer processor configured to execute the instructions to implement a plurality of safety controls.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: June 28, 2016
    Assignee: Nuvectra Corporation
    Inventors: Norbert Kaula, Yohannes Iyassu
  • Patent number: 9370619
    Abstract: Apparatus, for use with a fluid cartridge, that include a percutaneous port having an interior configured to receive the fluid cartridge, an implantable operative portion that has a fluid transfer device with an inlet and an outlet, and delivery/manifold tube with a manifold portion and a delivery portion, are disclosed.
    Type: Grant
    Filed: February 21, 2009
    Date of Patent: June 21, 2016
    Assignee: IncuMed, LLC
    Inventors: Alfred E. Mann, Tom Xiaohai He
  • Patent number: 9357968
    Abstract: Implantable sensor system including a sensor which is situated in a housing, the housing having a measurement region which is permeable for the parameters to be detected by the sensor, wherein the measurement region has an erodible protective coating which is permeable for the parameters to be detected by the sensor.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: June 7, 2016
    Assignee: DYCONEX AG
    Inventors: Marc Hauer, Thomas Doerr
  • Patent number: 9332974
    Abstract: A tissue thickness compensator may generally comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a third layer comprising a third medicament. The tissue thickness compensator may comprise a first layer comprising a first medicament, a second layer comprising a second medicament, and a reservoir comprising a third medicament disposed within the reservoir. The medicaments may be independently selected from a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a pharmaceutically active agent, a matrix metalloproteinase inhibitor, and combinations thereof. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: May 10, 2016
    Assignee: Ethicon Endo-Surgery, LLC
    Inventors: Cortney E. Henderson, Taylor W. Aronhalt, Chunlin Yang, Charles J. Scheib, Venkataramanan Mandakolathur Vasudevan, Mark D. Timmer, Richard W. Timm, Tamara Widenhouse, Steven G. Hall
  • Patent number: 9327071
    Abstract: An implantable fluid delivery system for use in hearing systems includes an implantable fluid pump having a fluid chamber having at least one wall with a membrane, an inlet and an outlet in fluid communication with the fluid chamber, and a floating mass transducer coupled to the membrane. The membrane is configured to move in a first direction increasing a volume of the fluid chamber and to move in a second direction decreasing the volume of the fluid chamber, and the floating mass transducer is configured to cause the membrane to move in the first and second directions. The system further includes an implantable hearing device having one or more fluid channels in fluid communication with the fluid pump.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: May 3, 2016
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Roland Hessler
  • Patent number: 9314511
    Abstract: The present invention is directed to systems and methods for delivering therapy for a cardiac disorder, wherein the system comprises a source for supplying a protein formulation containing a protein that is otherwise deficient in cardiac cells in a patient with a cardiac disorder, and a catheter having a proximal end and a distal end for delivering the protein formulation to the pericardial sac region of a human heart.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: April 19, 2016
    Assignee: Medtronic, Inc.
    Inventor: John G. Keimel
  • Patent number: 9283331
    Abstract: A hypodermic needle system and method for reducing the incidence of infections due to administering fluids by injection to humans or animals is provided. The hypodermic needle system may include a needle with an insert disposed within its hollow channel to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. The hypodermic needle system may include a film that covers at least one surface of the needle or insert, and/or have a bent or curved tip to reduce the ability of infectious agents to adhere to said surface/space within the needle. Additionally, the hypodermic needle system may include an anti-infection agent, such as an antibiotic or antiseptic to further reduce the incidence of infections, and may include an attachment member which reduces the risk of infection.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: March 15, 2016
    Assignee: University of Utah Research Foundation
    Inventor: Randall J. Olson
  • Patent number: 9248013
    Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: February 2, 2016
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Bo Lu, Mark Humayun
  • Patent number: 9205241
    Abstract: Improved medical devices and methods are provided that are implantable at or near a target tissue site beneath the skin of a patient, the medical device comprising an adhesive sheet having a region configured to receive a solid or semi-solid drug depot, the drug depot disposed within the region of the adhesive sheet, the drug depot having at least one surface configured to release a therapeutically effective amount of the drug over a period of at least one day, wherein the adhesive sheet limits movement of the medical device at or near the target tissue site. In some embodiments, the medical device provided can include an effective amount of at least one analgesic and/or at least one anti-inflammatory agent at or near a target site, and can reduce, prevent or treat inflammation and/or pain, such as postoperative pain or orthopedic degenerative pathology pain.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: December 8, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Patent number: 9180245
    Abstract: A method, computer program product, and infusion pump assembly for administering a sequential, multi-part, infusion event, wherein the sequential, multi-part, infusion event includes a plurality of discrete infusion events. If a one-time infusion event is available to be administered, the administration of at least a portion of the plurality of discrete infusion events included within the sequential, multi-part, infusion event is delayed. The one-time infusion event is administered.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: November 10, 2015
    Assignee: DEKA Products Limited Partnership
    Inventors: Robert J. Bryant, Marc A. Mandro
  • Patent number: 9162024
    Abstract: Embodiments of an implantable electrolytic pump include a drug reservoir, a cannula fluidly coupled to the reservoir, a pumping mechanism for forcing liquid from the reservoir through the cannula, control circuitry for operating the pumping mechanism, and a power source comprising primary and auxiliary batteries in a stacked configuration, only the main battery being operatively coupled to the control circuitry during normal operation, the control circuitry operatively coupling the back-up battery upon detection of an electrical fault. The pump may further include a hermetic enclosure containing the control circuitry and the power source.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: October 20, 2015
    Assignee: MiniPumps, LLC
    Inventors: Changlin Pang, Fukang Jiang, Jason Shih, Sean Caffey, Mark Humayun, Yu-Chong Tai, Jeffrey Brennan, Raymond Peck
  • Patent number: 9144589
    Abstract: The present invention is concerned with a photosynthetic scaffold that delivers oxygen and its uses for tissue engineering and the treatment of ischemia.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: September 29, 2015
    Assignee: SYMBIOX, INC.
    Inventors: Jose-Tomas Eagana-Erazo, Hans-Gunther Machens, Ursula Hopfner, Joerg Nickelsen
  • Patent number: 9138281
    Abstract: Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: September 22, 2015
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Denise Zarins, Hanson Gifford, III, Mark Deem, Douglas Sutton, Howard R. Levin, Mark Gelfand