Abstract: A computer-implemented method includes receiving a signal associated with a characteristic of an actuation event of a medicament delivery device. The method includes establishing a communications link (e.g., via a short-range wireless protocol), between a mobile computing device and a medicament delivery device. A wireless first signal associated with a first motion profile of the medicament delivery device is then received from the medicament delivery device. A second signal associated with a second motion profile of the mobile computing device is generated. The method then includes producing a notification via the mobile computing device when A) a magnitude of the first motion profile is outside of a first threshold and B) a magnitude of the second motion profile is outside of a second threshold.

Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Abstract: An implantable drug delivery device and method for delivering a drug to a living body. The device includes a housing having at least one opening, a reservoir within the housing adapted to contain the drug, a temporary seal closing the at least one opening of the housing, and a heating element in thermal contact with the temporary seal. The heating element is adapted to generate heat in response to a magnetic field to melt the temporary seal and release the drug within the reservoir through the at least one opening of the housing.

Abstract: This invention is in the field of medical intervention related to the lacrimal system. The invention relates to a lacrimal system device or system and methods of using the device for drug delivery to the eye, sinuses and/or periocular tissues.

Abstract: Ingestible radio frequency identification (RFID) tags are disclosed. A system embodiment includes, but is not limited to, an RFID tag including a flexible substrate foldable between a planar configuration and a tubular configuration, a conductive element disposed on the flexible substrate, and an RFID tag chip electrically coupled with the conductive element; a capsule structured and dimensioned for ingestion by a biological subject, the capsule including a shell structured and dimensioned to enclose a medication for the biological subject simultaneously with the RFID tag when the flexible substrate is in the tubular configuration, but not when the flexible substrate is in the planar configuration; and a pH switch structure coupled to an exterior surface of the capsule, the pH switch configured to deactivate the RFID tag in a first configuration and to permit activation of the RFID tag in a second configuration within the biological subject.

Abstract: A pump including a disposable component including a disposable component inlet port coupled to a first disposable conduit in fluid communication with a fluid medium source, wherein the first disposable conduit includes a disposable piston pump assembly and a disposable bubble eliminator, and the first disposable conduit is in fluid communication with a disposable component outlet port, wherein the disposable bubble eliminator is in fluid communication with a lumen of the first disposable conduit and is operable to reduce a gas content of a fluid medium; wherein the disposable piston pump assembly is operable to pump the fluid medium from the disposable component inlet port, through the first disposable conduit and the disposable bubble eliminator, to the disposable component outlet port; and a reusable component including a reusable movable stage operable to compress the disposable piston pump assembly; and a reusable mechanical actuator operable to drive the movable stage.

Abstract: An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

Abstract: A method, computer program product, and infusion pump assembly for administering a sequential, multi-part, infusion event, wherein the sequential, multi-part, infusion event includes a plurality of discrete infusion events. If a one-time infusion event is available to be administered, the administration of at least a portion of the plurality of discrete infusion events included within the sequential, multi-part, infusion event is delayed. The one-time infusion event is administered.

Abstract: A drug delivery assembly is provided for delivering a medicament to a patient via a fluid flow path. The assembly includes a main body having a body housing with a body interface and a controller. The assembly also includes a cartridge having a cartridge housing with a cartridge interface configured to be removably associated to the body interface. A drug reservoir positioned within the cartridge housing is configured to contain a medicament and includes an outlet. An adhesive pad is associated with a surface of the cartridge housing and is configured to removably attach to a human body surface. The controller is configured to execute a drug delivery routine in which at least a portion of the medicament in the drug reservoir is delivered to a subject via the outlet and the fluid flow path when the main body is coupled to the cartridge.

Abstract: Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics).

Abstract: The devices, assemblies, and methods described herein utilize photoacoustic principals to create a jet of fluid using a ultrasonic resonance member and a pulsed laser light beam. The ultrasonic resonance member is a treated substrate having an liquid interface surface in contact with a fluid. When a pulsed laser light beam is applied to the treated substrate, pressure is generated via induced ultrasonic waves to urge the fluid into a jet stream.

Abstract: Embodiments relate to a system, comprising a timer module comprising a timer configured to set a time for a session, an infusion module comprising an infusing device configured for administering a drug to a patient, a patient monitoring module comprising a first sensor configured for monitoring a physiological condition of the patient, a drug monitoring and control module comprising a second sensor configured for monitoring a drug delivery to the patient, an alarm generating module comprising signal generator that generates an indication signal when a value of the physiological condition is outside a predefined threshold, and wherein the time for the session is dynamically adjusted during the session, and wherein the drug delivery is dynamically adjusted during the session.

Abstract: The present invention provides a sampling capsule and a sampling capsule system. The sampling capsule includes an enclosure, a partition wall arranged in the enclosure, and a sample chamber enclosed by the partition wall and the enclosure at a first side of the partition wall. The sampling capsule further includes an inner sample inlet on the partition wall, an outer sample inlet, a sampling tube and a switch assembly. The outer sample inlet is on the enclosure at a second side of the partition wall. The sampling tube connects the outer sample inlet and the inner sample inlet, and the switch assembly clamps or unclamps a portion of the sampling tube. When sampling is needed, the switch assembly unclamps the sampling tube to sample liquid. When sampling ends, the switch assembly tightly clamps the sampling tube to prevent sample liquid leak or contamination.

Abstract: A system and method for altering bone growth on and within an orthopedic implant that includes an implant body; a plurality of electrodes, wherein each electrode is at least partially embedded in the implant body, and comprises: a set of primary electrodes comprising at least one electrode, wherein a non-embedded segment of each primary electrode is proximal to a bone growth region, a set of secondary electrodes comprising at least one electrode, wherein a non-embedded segment of each secondary electrode is distal to the bone growth region, and wherein the plurality of electrodes are configured to function in a stimulation operating mode, such that a subset of primary electrodes function as cathodes and a subset of secondary electrodes function as anodes; a control system comprising a processor, and circuitry that connects to the plurality of electrodes; and a power system.

Abstract: Provided herein are methods, compositions, devices, and systems for the 3D printing of biomedical implants. In particular, methods and systems are provided for 3D printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).

Abstract: Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

Abstract: An implantable connector for connecting an electronics package and a neural interface is made by way of a compressible contacts (e.g., a spring) that physical contacts a corresponding exposed bond pad. The compressible contact is held in compression with the exposed bond pad using a mechanical coupler. The compressible contact is physically separated and electrically isolated from other contacts by way of a compressible gasket. The compressible gasket is also held in compression using the mechanical coupler.

Abstract: An elastic physiological patch includes a patch assembly and an implant assembly. The patch assembly includes an electronic device, and a soft patch body defining a chamber for receiving the electronic device. The implant assembly is mountable to the electronic device and includes an implant which is capable of being driven to partially pass through the patch body and which is adapted to be implanted in the skin of a subject. The implant and the patch body cooperatively seal the chamber.

Abstract: An intravascular blood pump for percutaneous insertion comprises a catheter (10) and a pumping device (1) attached to the catheter (10). The catheter (10) extends along a longitudinal axis and has a distal end (11) and a proximal end (12) opposite the distal end (11). The catheter (10) comprises an elongate stiffening structure (15) extending continuously longitudinally along the length of the catheter (10) between the proximal end (11) and the distal end (12) of the catheter (10). The stiffening structure (15) may comprise a shape-memory material, such as Nitinol. It may be in the form of a wire that extends loosely through the lumen of the catheter and helps to avoid or significantly reduce kinks in the catheter.

Abstract: A method is provided including disposing central electrodes outside and in electrical contact with a skull of a head of a subject identified as at risk of or suffering from Alzheimer's disease, within one cm of a sagittal midplane of the skull; and disposing peripheral electrodes outside and in electrical contact with the skull, superior to an orbitomeatal plane of the skull and inferior to a first plane midway between the orbitomeatal plane and a cranial vertex of the skull, the first plane parallel to the orbitomeatal plane. The subject is treated by clearing amyloid beta, tau protein, and/or metal ions from brain parenchyma to a subarachnoid space, by activating control circuitry to apply respective currents between one or more of the central electrodes and two or more of the peripheral electrodes, and configure the central electrodes as cathodes and the peripheral electrodes as anodes. Other embodiments are also described.

Abstract: This document relates to methods and materials for treating urinary calculi. For example, ureteral orifice devices and methods for using ureteral orifice devices to treat urinary calculi present within a mammal (e.g., a human) are provided.

Abstract: A method and system for monitoring analytes in the circulatory system of an individual is provided. A biological sensor is implanted in the bone marrow of a patient and may be self contained within a housing. The biological sensor measures physiological parameters of a patient, including analytes, on a fixed or adjustable schedule. The biological sensor includes a control unit having a transmitter and an energy source for providing energy to the control unit. The biological sensor may be used to adjust other medical treatments and devices in a closed or semi closed loop mechanism and/or predict patient treatment.

Abstract: An implantable therapy delivery device that includes a porous pouch and a cell encapsulation device configured to fit inside the porous pouch. The porous pouch may include a bio-absorbable material and/or a vascularization promotor, and the porous pouch may be packaged separately from the cell encapsulation device.

Abstract: A filling member (43) in a medicament delivery device (1), the filling member (43) includes a first conduit (12) that fluidly communicates with a reservoir (4) and a second conduit (14) that fluidly communicates with a pump (3) and with the first conduit (12), wherein the filling member (43) provides two-way medicament flow that enters the reservoir (4) via the first conduit (12), exits the reservoir (4) into the first conduit (12) and the second conduit (14), and exits the second conduit (14) to the pump (3). The reservoir (4) includes a reservoir tube (44A) having one end that is formed with the reservoir (4), and the reservoir tube (44A) having another end that is press fit to the filling member (43) to establish fluid communication with the reservoir (4).

Abstract: Systems and methods are disclosed that include a guide catheter apparatus insertable through a external body passage of a subject. The guide catheter apparatus includes a substantially rigid shaft and a handle. The shaft has a proximal opening, a distal opening, and a lumen extending between the proximal opening and the distal opening. The handle has a structure to allow a position of the guide catheter to be controlled by some or all of three fingers of one hand of an operator of the handle. The structure of the handle is adapted to permit the operator to position a thumb and index finger of the hand to manipulate a working device inserted into the lumen of the guide catheter, where the working device is manipulable via a portion of the working device immediately adjacent to the handle.

Abstract: A communication platform at least partially implements secure communications between a medical device and a trusted authority (TA) service provider. The secure communications prevent access to the secure communications by the communication platform while permitting access to the secure communications at the medical device and/or at the trusted authority service provider.

Abstract: Systems and methods relate to an ambulatory medicament device that can generate a dose control signal to cause a medicament pump to infuse medicament into a subject. The system can analyze status to determine whether an alarm condition for the ambulatory medicament device or for a subject is already present in a list of pending alarm conditions. If the alarm is not present, the system can determine a severity level of the alarm condition from among a plurality of severity levels and annunciate the alarm condition using one or more annunciation patterns selected based on the severity level of the alarm condition for the medicament device or for the subject. The system may maintain an indication of the alarm condition on the list of pending alarm conditions until the alarm condition is resolved.

Abstract: Percutaneous gas diffusion device. In one embodiment, the percutaneous gas diffusion device includes a core layer, an outer layer, and an intermediate layer. The core layer may be cylindrical and may include a gas-permeable, liquid-impermeable material. The outer layer may peripherally surround the core layer and may include a tissue-integrating material. The intermediate layer may peripherally surround the core layer and may be peripherally surrounded by the outer layer. The intermediate layer may include a barrier that prevents infiltration of tissue from the outer layer into the core layer and that additionally reduces diffusion of gas from the core layer into the outer layer. The percutaneous gas diffusion device may be coupled to a subcutaneous implant device, such as a subcutaneous container holding implanted cells and/or tissue, a subcutaneous electrochemical oxygen concentrator, or a water electrolyzer.

Abstract: A thin-film covered stent device may include a thin-film mesh and a stent backbone covered by the thin-film mesh, thereby forming a dual-layer stent structure. The thin-film covered stent device may have smaller pores and a high pore density compared to conventional stents. For example, the thin-film covered stent device may have a slit length of between 50 and 250 micrometers and a pore density of between 134 and 227 pores per mm2. The thin-film covered stent device facilitates rapid healing of tissue defects such as those encountered during the endovascular treatment of an aneurysm.

Abstract: An infusion set, patch pump, or elements thereof, having an exemplary catheter (14) provided with one or more channels, grooves and coatings (24, 34, 44), configured and arranged to provide a degree of strength and flexibility. The catheter (14) can also have an exemplary flexible union with the hub (12) having at least one of a ball-and-socket joint (66, 68), a sliding plate (86), and a flexible bushing (106), and which is sealed to allow even further movement of the catheter (14) while preventing leakage of medication through the junction. In doing so, a number of benefits associated with the use of rigid materials in catheter construction can be provided while at the same time, benefits associated with the use of flexible materials in catheter construction and/or flexible engagement with the hub can also be provided.

Abstract: The present invention provides a semiautomatic syringe with improved safety including: a main body; a receptacle which is installed at one side of the main body, receives therein a set amount of infusion solution, and has a set pressure; an infusion solution tube which extends by a set length while penetrating the main body, connects with the receptacle, and provides a passageway for moving the infusion solution; a protective cover which is installed at the other side of the main body, connects with the infusion solution tube, extends by a set length, and has a hollow portion; an injection needle which is provided in the protective cover and has an injection hole formed to discharge the infusion solution, which moves through the infusion solution tube, to the outside; and a flow rate adjusting member which is installed in the main body and adjusts a movement amount of the infusion solution by opening and closing the passageway of the infusion solution tube, in which the injection needle is provided in a state

Abstract: The invention relates a system for implanting an implantable device in bone tissue, a processing unit for such system, a method of implanting an implantable device and a method of providing information for an implanting of an implantable device. In view of the finding that a fat content in cancellous bone is higher than a fat content in compact bone, the lipids fraction, which can be determined by optical means, e.g. spectroscopy, can be used to determine correct screw placement in healthy bone.

Abstract: Methods and devices are provided for the use of thin-film cuffs on endovascular grafts. A method includes forming a fenestrated thin-film Nitinol sheet, expanding the fenestrated thin-film Nitinol sheet to expand the fenestrations, and attaching the expanded thin-film Nitinol sheet to a longitudinal end of a cover for an endovascular graft to form a cuff for the endovascular graft. The method may further include implanting the endovascular graft into a blood vessel. An endovascular graft may include a cover having a proximal and distal end, a proximal thin-film mesh cuff extending from the proximal end, and a distal thin-film mesh cuff extending form the distal end.

Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.

Abstract: The invention relates to a balloon catheter featuring—at least on portions of the outward-turned surface of the dilatable area—hair-like extensions, with the average diameter D, the average length L, and the average center-to-center distance P of the hair-like extensions to each other being selected such that a drug on the balloon surface covered with hair-like extensions can essentially be secured by means of capillary forces.

Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Abstract: Described is a bioelectric stimulating device for reducing orthodontic treatment time (braces) with post-treatment stability enhancement. The device and associated methods provide a native sustainable optimal release of an increase in the quantity of the right cells and proteins over time and in the right sequence to optimize tooth movement with the braces by accelerating bone resorption at the leading edge of the tooth during movement. This acceleration phenomenon is responsible for being able to shorten orthodontic treatment time. Following the final alignment of the teeth, the same device can utilize the native response and accelerate the tooth/bone interface stability by targeting specific cells and proteins that are responsible for bone deposition (hardening) in order to shorten the retention phase, while greatly decreasing the chance of relapse (instability).

Abstract: Embodiments disclosed herein include devices for time release of measured quantities of an active ingredient and storage of animal management information. One embodiment disclosed herein releases an active ingredient, which is useful in the ruminant art, within the rumen and, then, at optionally varied intervals, releases additional doses into the same environment. The active ingredients are compartmentalized and, upon receiving an appropriate signal, use a magnetic field to expel the active ingredient into the rumen of the animal. The doses of active ingredient may be delivered simultaneously, sequentially, or independently. Further, the doses of active ingredient may be the same active ingredient or different active ingredients, in any formulation. Another embodiment described herein stores animal management information, such as identification or dosage information, and wirelessly communicates the stored information to an external device.

Abstract: Implants are placed in turbinate mucosal tissue using a surgical device having a proximal grip portion and a distal hollow sharp needle portion that is manipulated using the grip portion and inserted submucosally into mucosal turbinate tissue. One or more biodegradable, drug-eluting solid implants are disposed within the needle. The implants have one or more implant withdrawal-discouraging, mucosal tissue-engaging surface features along their length. An actuator disposed within the device is used to deliver one or more of the implants from the needle into the mucosal turbinate tissue and submucosally bury at least one such tissue-engaging feature therein.

Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.

Abstract: An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. A primary power supply is configured to provide primary electrical energy to at least a portion of the processing logic. A backup power supply is configured to provide backup electrical energy to the at least a portion of the processing logic in the event that the primary power supply fails to provide the primary electrical energy to the at least a portion of the processing logic.

Abstract: The present invention discloses a liquid medicine injection device that is attached to a patient's body to inject liquid medicine such as insulin at an appropriate time. A liquid medicine injection device according to the present invention includes: a case; a liquid medicine tank that is disposed in the case and where liquid medicine is received; an electro-osmosis pump that is connected with the liquid medicine tank and moves the liquid medicine; a needle assembly that receives the liquid medicine by being connected to the electro-osmosis pump and injects the received liquid medicine into a human body; and an adhesive member combined to the case and attached to the human body.

Abstract: A method for reducing small volume subcutaneous leaks of therapeutic fluids during procedures to refill an implantable medical device includes reducing pressure in a reservoir of the device. A refill needle can be percutaneously inserted into a fill port in communication with the reservoir and therapeutic fluid can be delivered through the needle into the reservoir. Reduced reservoir pressure upon withdrawal of the refill needle from the port can result in reduced subcutaneous leakage of the therapeutic fluid.

Abstract: The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.

Abstract: Described are implantable devices having expandable reservoirs for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and includes a retention structure and a penetrable element coupled to and extending within at least a portion of the retention structure. A porous drug release mechanism is positioned in fluid communication with an outlet of the device; and a reservoir having a volume configured to contain one or more therapeutic agents is in fluid communication with the outlet through the porous drug release mechanism. The device is at least partially inserted along an axis of insertion. The reservoir enlarges from an insertion configuration having a first three-dimensional shape to an expanded configuration having a second three-dimensional shape, the second three-dimensional shape being eccentrically positioned relative to the axis of insertion.

Abstract: Apparatus include an external controller, a memory storing trim settings corresponding to a plurality of modes of operation, and a memory device. The memory device includes an array of memory cells, an internal controller, and a trim register array. The internal controller is configured to load trim settings to a trim register of the trim register array in response to a command received from the external controller, to set trims in response to the trim settings in response to receiving an access command associated with the trim settings, and to perform an access operation on the array of memory cells using the trims in response to receiving the access command. The external controller is configured, in response to receiving a command indicative of a desired mode of operation, to select trim settings corresponding to the desired mode of operation, and to transmit the selected trim settings to the memory device.

Abstract: Described are implants for placing in a body, tools for delivering the implants, and systems and methods for using implants and tools for placing in a body and more particularly to nasal implants, tools for delivering nasal implants, and systems and methods for using such implants and tools. A tool may include a hand-held implant delivery device that holds, moves, orients, inserts, or shapes an implant. An implant may be a biodegradable, longitudinal implant that may be oriented for implantation by an implant delivery device.

Abstract: A system includes a portable device and an external device connected wirelessly. Graphical user interface data determines a user interface functionality to be executed in a user interface of the external device in the portable apparatus, and is transmitted to the external device. The user interface functionality includes presenting at least one graphical interaction element on the user interface and receiving user input as a response to the user interacting with the graphical interaction element. The input data received from the user interface is used in the portable device to control a computer process relating to physiological data.