Implanted Dynamic Device Or System Patents (Class 604/891.1)
  • Patent number: 11135363
    Abstract: Systems and methods relate to an ambulatory medicament device that can generate a dose control signal to cause a medicament pump to infuse medicament into a subject. The system can analyze status to determine whether an alarm condition for the ambulatory medicament device or for a subject is already present in a list of pending alarm conditions. If the alarm is not present, the system can determine a severity level of the alarm condition from among a plurality of severity levels and annunciate the alarm condition using one or more annunciation patterns selected based on the severity level of the alarm condition for the medicament device or for the subject. The system may maintain an indication of the alarm condition on the list of pending alarm conditions until the alarm condition is resolved.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: October 5, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Michael J. Rosinko, David Chi-Wai Lim, Edward R. Damiano, Firas H. El-Khatib, Himanshu Patel
  • Patent number: 11033666
    Abstract: Percutaneous gas diffusion device. In one embodiment, the percutaneous gas diffusion device includes a core layer, an outer layer, and an intermediate layer. The core layer may be cylindrical and may include a gas-permeable, liquid-impermeable material. The outer layer may peripherally surround the core layer and may include a tissue-integrating material. The intermediate layer may peripherally surround the core layer and may be peripherally surrounded by the outer layer. The intermediate layer may include a barrier that prevents infiltration of tissue from the outer layer into the core layer and that additionally reduces diffusion of gas from the core layer into the outer layer. The percutaneous gas diffusion device may be coupled to a subcutaneous implant device, such as a subcutaneous container holding implanted cells and/or tissue, a subcutaneous electrochemical oxygen concentrator, or a water electrolyzer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: June 15, 2021
    Inventors: Anthony A. Ferrante, Simon G. Stone
  • Patent number: 11020254
    Abstract: A thin-film covered stent device may include a thin-film mesh and a stent backbone covered by the thin-film mesh, thereby forming a dual-layer stent structure. The thin-film covered stent device may have smaller pores and a high pore density compared to conventional stents. For example, the thin-film covered stent device may have a slit length of between 50 and 250 micrometers and a pore density of between 134 and 227 pores per mm2. The thin-film covered stent device facilitates rapid healing of tissue defects such as those encountered during the endovascular treatment of an aneurysm.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 1, 2021
    Assignee: Monarch Biosciences, Inc.
    Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
  • Patent number: 11013854
    Abstract: An infusion set, patch pump, or elements thereof, having an exemplary catheter (14) provided with one or more channels, grooves and coatings (24, 34, 44), configured and arranged to provide a degree of strength and flexibility. The catheter (14) can also have an exemplary flexible union with the hub (12) having at least one of a ball-and-socket joint (66, 68), a sliding plate (86), and a flexible bushing (106), and which is sealed to allow even further movement of the catheter (14) while preventing leakage of medication through the junction. In doing so, a number of benefits associated with the use of rigid materials in catheter construction can be provided while at the same time, benefits associated with the use of flexible materials in catheter construction and/or flexible engagement with the hub can also be provided.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 25, 2021
    Inventors: Peter Skutnik, Joshua Horvath, Robert Banik, Gary Searle, Eric Bene
  • Patent number: 10993748
    Abstract: The invention relates a system for implanting an implantable device in bone tissue, a processing unit for such system, a method of implanting an implantable device and a method of providing information for an implanting of an implantable device. In view of the finding that a fat content in cancellous bone is higher than a fat content in compact bone, the lipids fraction, which can be determined by optical means, e.g. spectroscopy, can be used to determine correct screw placement in healthy bone.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: May 4, 2021
    Inventors: Drazenko Babic, Thirukumaran Thangaraj Kanagasabapathi, Susanne Maaike Valster, Bernardus Hendrikus Wilhelmus Hendriks
  • Patent number: 10994079
    Abstract: The present invention provides a semiautomatic syringe with improved safety including: a main body; a receptacle which is installed at one side of the main body, receives therein a set amount of infusion solution, and has a set pressure; an infusion solution tube which extends by a set length while penetrating the main body, connects with the receptacle, and provides a passageway for moving the infusion solution; a protective cover which is installed at the other side of the main body, connects with the infusion solution tube, extends by a set length, and has a hollow portion; an injection needle which is provided in the protective cover and has an injection hole formed to discharge the infusion solution, which moves through the infusion solution tube, to the outside; and a flow rate adjusting member which is installed in the main body and adjusts a movement amount of the infusion solution by opening and closing the passageway of the infusion solution tube, in which the injection needle is provided in a state
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 4, 2021
    Inventor: Hwi Hwa Kim
  • Patent number: 10932896
    Abstract: Methods and devices are provided for the use of thin-film cuffs on endovascular grafts. A method includes forming a fenestrated thin-film Nitinol sheet, expanding the fenestrated thin-film Nitinol sheet to expand the fenestrations, and attaching the expanded thin-film Nitinol sheet to a longitudinal end of a cover for an endovascular graft to form a cuff for the endovascular graft. The method may further include implanting the endovascular graft into a blood vessel. An endovascular graft may include a cover having a proximal and distal end, a proximal thin-film mesh cuff extending from the proximal end, and a distal thin-film mesh cuff extending form the distal end.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: March 2, 2021
    Assignee: Monarch Biosciences, Inc.
    Inventors: Ian A. Cook, Colin Kealey, Vikas Gupta
  • Patent number: 10905590
    Abstract: Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: February 2, 2021
    Assignee: Alcon Inc.
    Inventors: Eugene de Juan, Jr., Stephen Boyd, Mark E. Deem, Hanson S. Gifford, III, Dan Rosenman
  • Patent number: 10786155
    Abstract: A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: September 29, 2020
    Assignee: Cognos Therapeutics Inc.
    Inventors: Yehoshua Shachar, Thomas Chen, Thomas J. Lobl, Jeffrey A. Brydle, Juan R. Gonzalez, Virote Indravudh, Christian Merot, Allan R. Schwartz, Chad Srisathapat
  • Patent number: 10786657
    Abstract: The invention relates to a balloon catheter featuring—at least on portions of the outward-turned surface of the dilatable area—hair-like extensions, with the average diameter D, the average length L, and the average center-to-center distance P of the hair-like extensions to each other being selected such that a drug on the balloon surface covered with hair-like extensions can essentially be secured by means of capillary forces.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: September 29, 2020
    Assignee: BIOTRONIK VI Patent AG
    Inventors: Nina Adden, Bettina Surber
  • Patent number: 10695563
    Abstract: Described is a bioelectric stimulating device for reducing orthodontic treatment time (braces) with post-treatment stability enhancement. The device and associated methods provide a native sustainable optimal release of an increase in the quantity of the right cells and proteins over time and in the right sequence to optimize tooth movement with the braces by accelerating bone resorption at the leading edge of the tooth during movement. This acceleration phenomenon is responsible for being able to shorten orthodontic treatment time. Following the final alignment of the teeth, the same device can utilize the native response and accelerate the tooth/bone interface stability by targeting specific cells and proteins that are responsible for bone deposition (hardening) in order to shorten the retention phase, while greatly decreasing the chance of relapse (instability).
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: June 30, 2020
    Inventors: Howard J. Leonhardt, Jorge Genovese, John Joseph Marchetto
  • Patent number: 10639463
    Abstract: Embodiments disclosed herein include devices for time release of measured quantities of an active ingredient and storage of animal management information. One embodiment disclosed herein releases an active ingredient, which is useful in the ruminant art, within the rumen and, then, at optionally varied intervals, releases additional doses into the same environment. The active ingredients are compartmentalized and, upon receiving an appropriate signal, use a magnetic field to expel the active ingredient into the rumen of the animal. The doses of active ingredient may be delivered simultaneously, sequentially, or independently. Further, the doses of active ingredient may be the same active ingredient or different active ingredients, in any formulation. Another embodiment described herein stores animal management information, such as identification or dosage information, and wirelessly communicates the stored information to an external device.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: May 5, 2020
    Assignee: JVD, INC.
    Inventors: Michael L. Vandierendonck, Marcelo A. Martinez
  • Patent number: 10596330
    Abstract: Implants are placed in turbinate mucosal tissue using a surgical device having a proximal grip portion and a distal hollow sharp needle portion that is manipulated using the grip portion and inserted submucosally into mucosal turbinate tissue. One or more biodegradable, drug-eluting solid implants are disposed within the needle. The implants have one or more implant withdrawal-discouraging, mucosal tissue-engaging surface features along their length. An actuator disposed within the device is used to deliver one or more of the implants from the needle into the mucosal turbinate tissue and submucosally bury at least one such tissue-engaging feature therein.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: March 24, 2020
    Inventors: Jennifer G. Medina, Drew P. Amery, Dana A. Oliver, Jie Wen
  • Patent number: 10583247
    Abstract: An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. A primary power supply is configured to provide primary electrical energy to at least a portion of the processing logic. A backup power supply is configured to provide backup electrical energy to the at least a portion of the processing logic in the event that the primary power supply fails to provide the primary electrical energy to the at least a portion of the processing logic.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: March 10, 2020
    Inventor: Marc A. Mandro
  • Patent number: 10583245
    Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: March 10, 2020
    Assignee: AMGEN INC.
    Inventors: Adam B. McCullough, Lawrence S. Ring
  • Patent number: 10549030
    Abstract: The present invention discloses a liquid medicine injection device that is attached to a patient's body to inject liquid medicine such as insulin at an appropriate time. A liquid medicine injection device according to the present invention includes: a case; a liquid medicine tank that is disposed in the case and where liquid medicine is received; an electro-osmosis pump that is connected with the liquid medicine tank and moves the liquid medicine; a needle assembly that receives the liquid medicine by being connected to the electro-osmosis pump and injects the received liquid medicine into a human body; and an adhesive member combined to the case and attached to the human body.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: February 4, 2020
    Assignee: EOFlow Co., Ltd.
    Inventors: Seung Ha Kim, Jae Hong Kim, Jesse Jaejin Kim, Yongchul Song, Jongook Jeong
  • Patent number: 10525247
    Abstract: A method for reducing small volume subcutaneous leaks of therapeutic fluids during procedures to refill an implantable medical device includes reducing pressure in a reservoir of the device. A refill needle can be percutaneously inserted into a fill port in communication with the reservoir and therapeutic fluid can be delivered through the needle into the reservoir. Reduced reservoir pressure upon withdrawal of the refill needle from the port can result in reduced subcutaneous leakage of the therapeutic fluid.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: January 7, 2020
    Assignee: Medtronic, Inc.
    Inventors: Mark A. Bellrichard, Brian W. Ball, Kenneth J. Kahle, Mary M. Morris, Michael P. Piette
  • Patent number: 10518002
    Abstract: The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: December 31, 2019
    Inventor: Jeffrey Olson
  • Patent number: 10500091
    Abstract: Described are implantable devices having expandable reservoirs for the sustained release of therapeutic agents. The device is configured to be at least partially implanted in an eye and includes a retention structure and a penetrable element coupled to and extending within at least a portion of the retention structure. A porous drug release mechanism is positioned in fluid communication with an outlet of the device; and a reservoir having a volume configured to contain one or more therapeutic agents is in fluid communication with the outlet through the porous drug release mechanism. The device is at least partially inserted along an axis of insertion. The reservoir enlarges from an insertion configuration having a first three-dimensional shape to an expanded configuration having a second three-dimensional shape, the second three-dimensional shape being eccentrically positioned relative to the axis of insertion.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: December 10, 2019
    Assignee: ForSight Vision4, Inc.
    Inventors: Bradley G. Bachelder, Randolph E. Campbell, Darren G. Doud, Signe R. Erickson, Kevin W. Sacherman
  • Patent number: 10468105
    Abstract: Apparatus include an external controller, a memory storing trim settings corresponding to a plurality of modes of operation, and a memory device. The memory device includes an array of memory cells, an internal controller, and a trim register array. The internal controller is configured to load trim settings to a trim register of the trim register array in response to a command received from the external controller, to set trims in response to the trim settings in response to receiving an access command associated with the trim settings, and to perform an access operation on the array of memory cells using the trims in response to receiving the access command. The external controller is configured, in response to receiving a command indicative of a desired mode of operation, to select trim settings corresponding to the desired mode of operation, and to transmit the selected trim settings to the memory device.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: November 5, 2019
    Assignee: Micron Technology, Inc.
    Inventor: Terry Grunzke
  • Patent number: 10398545
    Abstract: Described are implants for placing in a body, tools for delivering the implants, and systems and methods for using implants and tools for placing in a body and more particularly to nasal implants, tools for delivering nasal implants, and systems and methods for using such implants and tools. A tool may include a hand-held implant delivery device that holds, moves, orients, inserts, or shapes an implant. An implant may be a biodegradable, longitudinal implant that may be oriented for implantation by an implant delivery device.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: September 3, 2019
    Assignee: Spirox, Inc.
    Inventors: Michael H. Rosenthal, Scott J. Baron, Donald A. Gonzales, Iyad S. Saidi
  • Patent number: 10313420
    Abstract: A system includes a portable device and an external device connected wirelessly. Graphical user interface data determines a user interface functionality to be executed in a user interface of the external device in the portable apparatus, and is transmitted to the external device. The user interface functionality includes presenting at least one graphical interaction element on the user interface and receiving user input as a response to the user interacting with the graphical interaction element. The input data received from the user interface is used in the portable device to control a computer process relating to physiological data.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: June 4, 2019
    Assignee: Polar Electro OY
    Inventors: Niclas Granqvist, Mika Erkkila, Olli Komulainen
  • Patent number: 10292831
    Abstract: A system and method for electrical stimulation in an orthopedic implant that includes at least one implantable component with an implant body, a plurality of electrodes, and implant circuitry is effective to convert an external wireless power transmission to an electrical current and effective to control the plurality of electrodes; and at least one non-implant with a power source, and transmitter circuitry to generate the electromagnetic field that couples with the implant circuitry.
    Type: Grant
    Filed: March 19, 2016
    Date of Patent: May 21, 2019
    Inventors: Erik Zellmer, Rory Murphy
  • Patent number: 10264972
    Abstract: A mechanism is provided. The mechanism includes a user device and a smart pill within a host. The smart pill is communicatively connected to the user device for transmitting and receiving secure communications. Settings of the smart pill while in the host are configured to be changed based on patient category data of the host.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: April 23, 2019
    Inventors: James R. Kozloski, Clifford A. Pickover
  • Patent number: 10251553
    Abstract: A mechanism is provided. The mechanism includes a user device and a smart pill within a host. The smart pill is communicatively connected to the user device for transmitting and receiving secure communications. Settings of the smart pill while in the host are configured to be changed based on patient category data of the host.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: April 9, 2019
    Inventors: James R. Kozloski, Clifford A. Pickover
  • Patent number: 10226587
    Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 12, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry B. Gray, Russell H. Beavis
  • Patent number: 10143770
    Abstract: The present invention relates to a photocatalytic apparatus and a heating, ventilating, and air conditioning (HVAC) equipment for a vehicle comprising the same and, more specifically, to a photocatalytic apparatus and HVAC equipment for a vehicle comprising the same, wherein the photocatalytic apparatus may sterilize and deodorize an evaporator in addition to purifying air introduced into an HVAC case and may continuously maintain sterilization and deodorization functions by efficiently radiating heat generated from the photocatalytic apparatus.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: December 4, 2018
    Assignee: HANON SYSTEMS
    Inventors: Jae Ho Kim, Ki Hong Kim, Ji-Yong Park, Tae Yong Park, Yong Jun Jee
  • Patent number: 10130757
    Abstract: A medical therapy system including liquid detection is disclosed. A medical therapy includes a case with an interior and an exterior. Within the interior of the case is the liquid detection system that includes a first electrode set with a first positive electrode and a first negative electrode. The liquid detection system further includes an impedance measurement circuit coupled to the first electrode set to determine impedance values between the first positive electrode and the first negative electrode. A threshold detector compares impedance values between the first electrode set to a first threshold impedance. A microprocessor is programmed to initiate an alarm when measured impedance from the first electrode set is below the first threshold impedance.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: November 20, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Yongbo Wang, Steve Chow
  • Patent number: 10123981
    Abstract: Methods, systems, devices, and medicaments are provided for locally administering to a pelvic-area organ or tissue structure in a patient at least one drug continuously or continually over a treatment period of 24 hours or more in an amount effective to achieve a therapeutic effect in another organ or tissue structure by means of shared or convergent pelvic afferent pathways. The methods systems, devices, and medicaments can be used in the treatment of IC/BPS, chronic pelvic pain, vulvodynia, orchialgia, urethral syndrome, dysparenia, chronic prostatitis, chronic pelvic pain, levator ani syndrome, irritative bowel syndrome, or a combination thereof. The drug may include anesthetic agents, analgesic agents, antispasmodic agents, antimuscarinic agents, and combinations thereof. The drug may be released from a drug delivery device or a sustained release composition deployed inside the bladder.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 13, 2018
    Assignee: ALLERGAN, INC.
    Inventors: Julie Himes, Dennis Giesing, Cheryl Larrivee-Elkins, Michael J. Cima, Purnanand Sarma, Paul Goldenheim
  • Patent number: 10105093
    Abstract: A device comprising: means for obtaining a parameter of a sample of body fluid from a user; means for using information provided by one or more sensors to calculate a measure of physical activity of the user; means for calculating a medicament dose using at least in part the measured parameter and the measure of physical activity of the user; and means for indicating the calculated medicament dose to the user.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: October 23, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Michael Schabbach, Jörg Heisiep, Stephan Müller-Pathle, Ross MacArthur
  • Patent number: 10105317
    Abstract: A drug delivery method for effective drug application is disclosed in this invention. In this method, a micro-carrier delivers an encapsulated, desired drug directly to targeted sites without significant interactions with other components in the biological system in the pathway. In one embodiment, a micro-carrier containing encapsulated drug is first delivered to the general area for treatment. It then scans the area and selectively attaches itself the cell site or organ location to be treated. Finally, the desired drug contained in the micro-carrier is released to the attached cell or organ. In another embodiment, a micro-device is first used to process the general area to be treated to enhance differentiation in properties (such as surface charge) between healthy cells and unhealthy cells (such as cancer cells). Drug encapsulated in the micro-carrier is next applied to preferentially attach onto the targeted sites (such as cancer cell sites) to be treated.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: October 23, 2018
    Assignee: Anpac Bio-Medical Science Co., Ltd.
    Inventors: Chris C. Yu, He Yu
  • Patent number: 10098765
    Abstract: The present invention relates to an implant (10), and particularly to an intraluminal endoprosthesis, comprising a body and at least one abluminal layer (3) disposed on the body, the abluminal layer preferably containing at least one pharmaceutically active substance. In order to protect the abluminal layer (3) from delamination or shearing, the abluminal layer (3) is additionally fastened to the implant body at least in a transition region (7) by way of at least one anchoring layer (5) disposed on the abluminal layer (3). In addition, methods for producing such an implant are described.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: October 16, 2018
    Assignee: BIOTRONIK AG
    Inventors: Bjoern Klocke, Alexander Borck
  • Patent number: 10092387
    Abstract: An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 9, 2018
    Assignees: California Institute of Technology, City of Hope
    Inventors: Yu-Chong Tai, Dongyang Kang, Hirotake Komatsu, Henry K. Lin, Yoko Mullen
  • Patent number: 10085828
    Abstract: Apparatus is provided, including a housing configured for insertion into a body of a subject; at least one oxygen reservoir disposed within the housing; and at least one layer of transplanted cells, disposed within the housing; and gaseous oxygen disposed within the at least one oxygen reservoir. Other embodiments are also described.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: October 2, 2018
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Yaki Stern, Yoram Rozy
  • Patent number: 10076324
    Abstract: Adjunct material to provide controlled drug elution is provided. In general, an implantable adjunct formed from at least one bioabsorbable polymer can be configured to be applied to tissue by a surgical stapler in conjunction with staples. The adjunct can be made from a plurality of fibers and it can have one or more medicants releasably retained therein that are effective to provide a desired effect on tissue in-growth in a predetermined manner. Release of each of the at least one medicants from the adjunct material can be controlled by a degradation rate of the at least one bioabsorbable polymer.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: September 18, 2018
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Michael J. Vendely, Frederick E. Shelton, IV
  • Patent number: 10039864
    Abstract: The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: August 7, 2018
    Assignee: Interface Biologics, Inc.
    Inventors: Roseita Esfand, J. Paul Santerre, Mark J. Ernsting, H. Hung Pham, Vivian Z. Wang, Meilin Yang
  • Patent number: 9981137
    Abstract: An implantable medical device that includes electrical circuitry for providing a therapy to a patient. The device also includes a housing forming an inner chamber that is adapted for receiving, at least a portion of the electrical circuitry. The device further includes a thermally conductive material that is configured to disperse heat from a first portion of the implantable medical device that is located in proximity to a heat generating component of the electrical circuitry, to a second portion of the implantable medical device that is not located in proximity to said heat generating component. The thermally conductive material is a discrete component separate from the electrical circuitry and the housing.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: May 29, 2018
    Assignee: Nuvectra Corporation
    Inventor: Jay H Eiger
  • Patent number: 9950151
    Abstract: An implantable medical system that comprises a gas unit for supplying gas that is essentially oxygen and at least one functional cells unit configured to receive oxygen from the gas unit so as to maintain the cells in a viable condition. The cells unit is flexible. Several embodiments are disclosed.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: April 24, 2018
    Assignee: Beta-O2 Technologies Ltd.
    Inventors: Avi Rotem, Uriel Barkai, Baruch Zimerman, Zohar Gendler
  • Patent number: 9919099
    Abstract: Implanted drug pump devices can be refilled via a fill port in the drug reservoir that includes a self-resealable septum.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 20, 2018
    Assignee: MINIPUMPS, LLC
    Inventors: Yu-Chong Tai, Jason Shih, Julian D. Kavazov
  • Patent number: 9810688
    Abstract: Device for use in a biosensor comprising a multisite array of test sites, the device being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological by modulating the pH or ionic gradient near the electrodes in such biosensor. The device provides a biosensor which is more accurate, reliable and the results of which are more reproducible. Analytic methods for more accurately measuring an analyte of interest in a biological sample are also provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 7, 2017
    Inventors: Nadezda Fomina, Christopher Johnson, Sam Kavusi, Habib Ahmad
  • Patent number: 9782430
    Abstract: A method for forming an embolism within a blood vessel is disclosed. The method includes including: implanting an oxidized cellulose embolization solution into a lumen of a blood vessel to form an embolism within the lumen. The oxidized cellulose is present in an amount from about 10 % by weight to 20 % by weight of the oxidized cellulose embolization solution. The method also includes adjusting recanalization time of the embolism, which may be adjusted by tailoring a degradation rate of the oxidized cellulose.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: October 10, 2017
    Assignee: Covidien LP
    Inventors: Rachit Ohri, Phillip D. Blaskovich
  • Patent number: 9770556
    Abstract: Methods and apparatus for translating a continuous-delivery delivery profile into a plurality of periodic bolus deliveries.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: September 26, 2017
    Assignee: Medallion Therapeutics, Inc.
    Inventors: Brian M. Shelton, Pedrum Minaie, Jon Douglas Newbill, Peter C. Lord
  • Patent number: 9764087
    Abstract: Systems for predicting a drug delivery profile as described herein include at least one drug pump and/or a controllable valve that produce a drug flow and dispense at least a first drug. The system also includes at least one carrier fluid pump and/or another controllable valve that produces a carrier fluid flow, a flow junction structure configured to receive the drug flow and the carrier fluid flow to produce a mixed flow, and a fluid path for carrying the mixed flow between the flow junction structure and a delivery point. The system further includes a processing device configured to predict the drug delivery profile at the delivery point based on determining a predicted time variation of drug concentration at the delivery point using at least a model of the mixed flow. The model includes a plurality of parameters related to propagation of the mixed flow through the fluid path.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 19, 2017
    Assignees: The General Hospital Corporation, Steward St. Elizabeth's Medical Center of Boston, Inc.
    Inventors: Robert A. Peterfreund, Michael Parker, Nathaniel M. Sims, Mark A. Lovich, Harold J. DeMonaco
  • Patent number: 9717845
    Abstract: A medical therapy system for delivering at least two therapies based on a geographic location of the medical therapy system is disclosed. The medical therapy system includes an infusion pump having a case that contains a processor, memory, a drive mechanism, a reservoir, a radio, and a sensor suite. The sensor suite includes a global positioning system (GPS) receiver to determine a location of the infusion pump. The processor receives the location of the infusion pump and executes first instructions stored in the memory. The processor executes second instructions stored in the memory only when the location of the infusion pump is within a safe zone defined around specified GPS coordinates.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: August 1, 2017
    Inventor: Emilian Istoc
  • Patent number: 9687638
    Abstract: The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: June 27, 2017
    Assignee: Medimetrics Personalized Drug Delivery
    Inventors: Hans Zou, Jeff Shimizu
  • Patent number: 9610429
    Abstract: Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly can be delivered to a patient, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The chemical can be delivered to the patient locally and/or systemically to stimulate the nerves and/or the brown adipocytes.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: April 4, 2017
    Assignees: Ethicon Endo-Surgery, Inc., The General Hospital Corporation
    Inventors: Jason L. Harris, Taylor W. Aronhalt, Dwight Henninger, James W. Voegele, Lee M. Kaplan, Nicholas Stylopoulos
  • Patent number: 9603997
    Abstract: Implanted drug pump devices can be refilled with a refill needle inserted through a fill port in the drug reservoir of the drug pump device. Proper needle insertion may be verified visually or using electrical, magnetic, optical, acoustic, or other suitable sensing mechanisms.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 28, 2017
    Assignee: MINIPUMPS, LLC
    Inventors: Mark Humayun, Yu-Chong Tai, Nenad Jelisavcic, Julian D. Kavazov, Fukang Jiang
  • Patent number: 9532705
    Abstract: In a method and a system for contact-free magnetic navigation of a magnetic body in a work space that is at least partially filled with a fluid, a thickening agent is added to the fluid. The use of a thickening agent as an additive for such a fluid is also described.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: January 3, 2017
    Assignee: Siemens Aktiengesellschaft
    Inventors: Stefan Foertsch, Henrik Keller
  • Patent number: 9533133
    Abstract: A venous access port assembly having a base, a peripheral surface, and a septum. The base defines an interior reservoir. The peripheral surface includes integrally molded X-ray discernable indicia identifying that the assembly is rated for power injection. The X-ray discernable indicia may extend through a height of the peripheral surface from a top surface to a bottom surface thereof. According to one aspect, the peripheral surface may be formed from X-ray discernable material, and the X-ray discernable indicia may be formed from the X-ray discernable material, or they may be formed by voids in the X-ray discernable material. According to another aspect, the peripheral surface may be formed from a radiotransparent or radiolucent material and applied with a radiopaque agent, and the X-ray discernable indicia may be one or more voids in the radiopaque agent or may be portions of the peripheral surface applied with the radiopaque agent.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: January 3, 2017
    Assignee: Medical Components, Inc.
    Inventors: Timothy M. Schweikert, Raymond R. Bizup, Kevin E. Sanford, Kenneth M. Zinn
  • Patent number: 9504787
    Abstract: An ambulatory infusion device for the infusion of a liquid drug into a patient's body over an extended time period includes an infusion cannula designed to be placed in the patient's subcutaneous tissue. At least two subcutaneous electrodes are comprised by the infusion cannula and are placed in the subcutaneous tissue. An impedance measuring unit is operatively coupled to the at least two electrodes and is configured to measure at least one impedance value between the at least two electrodes. A variation of the at least one impedance value reflects a displacement of interstitial fluid by drug upon drug administration. An event trigger unit is operatively coupled to the impedance measuring unit and being configured to evaluate the at least one impedance value and to generate an event trigger if evaluation of the at least one impedance value indicates the occurrence of an administration anomaly.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: November 29, 2016
    Assignee: Roche Diagnostics International AG
    Inventors: Reto Aeschilimann, James Leuenberger