Controlled Release Therapeutic Device Or System Patents (Class 604/890.1)
  • Patent number: 11324500
    Abstract: A surgical stapling device includes a tool assembly that has a staple cartridge that includes a perfluorocarbon (hereinafter “PFC”) solution that is injected into tissue when the surgical stapling device is fired to improve oxygenation of tissue being treated. In aspects of the disclosure, the tool assembly of the surgical stapling device includes a staple cartridge that has staples that are supported on pushers and an actuation sled that is movable through the staple cartridge into engagement with the pushers to eject staples from the staple cartridge. In certain aspects of the disclosure, the PFC solution is contained within the pushers of a staple cartridge of the tool assembly and the actuation sled includes protrusions that engage the pushers to eject the PFC solution from the pushers when the stapling device is fired.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: May 10, 2022
    Assignee: Covidien LP
    Inventor: Olesea Diaz-Chiosa
  • Patent number: 11311496
    Abstract: Methods, compositions, and devices for enhancing transdermal delivery of large agents.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: April 26, 2022
    Assignee: Eirion Therapeutics, Inc.
    Inventor: Jonathan Edelson
  • Patent number: 11304893
    Abstract: An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: April 19, 2022
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Richard Daniel Smith, Jr.
  • Patent number: 11304648
    Abstract: A system and method for identifying a stimulation location on a nerve is disclosed. The system includes an image-based navigation interface used to facilitate advancing a stimulation element within a patient body toward a target nerve stimulation site. Using the system one determines, separately for each potential target nerve stimulation site, a neuromuscular response of muscles produced upon applying a stimulation signal at the respective separate potential target stimulation sites. The image-based navigation interface is configured to display a graphic identification of which muscles were activated for each respective potential target nerve stimulation site upon applying the stimulation signal.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: April 19, 2022
    Assignee: INSPIRE MEDICAL SYSTEMS, INC.
    Inventors: John Rondoni, Mark A. Christopherson, Quan Ni
  • Patent number: 11266841
    Abstract: A method of securing an antenna assembly to a wearable article includes positioning a template carrying a first antenna at a desired position on the wearable article worn on a body of a patient. The desired position is in proximity to a wireless tissue stimulator implanted within the body. The method further includes marking a location of the desired position of the template against the wearable article, securing a first attachment feature to the wearable article at a mark located at the desired position, and attaching the antenna assembly to the wearable article at the first attachment feature. The antenna assembly includes a second antenna configured to send a signal carrying electrical energy to the wireless tissue stimulator and a housing carrying the second antenna. The housing includes a second attachment feature configured to engage the first attachment feature for positioning the second antenna adjacent the body.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: March 8, 2022
    Assignee: Stimwave Technologies Incorporated
    Inventors: Gary Perryman, Benjamin Speck
  • Patent number: 11241562
    Abstract: Ingestible devices with a relatively large payload volume or sample volume, as well as related components, systems and methods, are disclosed.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: February 8, 2022
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Russell B. Ford, Edward G. Solomon, Jeffrey A. Shimizu
  • Patent number: 11173247
    Abstract: A medicament delivery device includes a device housing for placing on the skin of a patient, the housing including a needle aperture; a needle for injecting a medicament, the needle arranged to pass through the needle aperture; and sensors configured to provide a signal when the housing is placed on the skin of the patient. The sensors are arranged around the needle aperture.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: November 16, 2021
    Assignee: Sanofi
    Inventors: Michael Schabbach, Beate Franke, Giuliano Pradel, Andrew Nelson
  • Patent number: 11116902
    Abstract: A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: September 14, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Firas H. El-Khatib, Edward R. Damiano
  • Patent number: 11109869
    Abstract: An embodiment of the invention is a shape memory polymer (SMP) foam designed to recover its original shape through exposure to a solvent. Thermo-responsive SMPs are polymers designed to maintain a programmed secondary shape until heated above their transition temperature, upon which the polymer recovers its original, or primary, shape. The thermo-responsive SMP foam is programmed to its secondary shape prior to use, typically compression of the foam to a small volume, and remains in this programmed shape until exposed to a selected solvent such as dimethyl sulfoxide or ethyl alcohol. Upon exposure to the solvent, the transition temperature of the SMP foam decreases below the temperature of the environment and the SMP foam actuates to its primary shape. The SMP foam is tailored to actuate upon exposure to specific solvents while minimizing or preventing actuation when exposed to water or other solvents.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: September 7, 2021
    Assignees: Lawrence Livermore National Security, LLC, The Texas A&M University System
    Inventors: Anthony Boyle, Keith Hearon, Duncan J. Maitland, Landon D. Nash, Thomas S. Wilson
  • Patent number: 11110278
    Abstract: A tool has an outer assembly, which includes a deployment tube, extending around, and moveable with respect to an inner assembly of the tool; the inner assembly includes a single pull wire and a distal member configured to engage an end of an implantable medical device. The deployment tube includes an articulating segment located just proximal to an enlarged distal-most portion, which contains the device and the distal member. Relatively soft and stiff sections of a composite sidewall define the articulating segment and extend alongside one another, such that, when the pull wire is actuated, the composite sidewall causes bending of the segment in two directions. A handle assembly of the tool includes a control member for the pull wire, and may further include a flushing subassembly that has a connector port located at an end of the handle assembly that is opposite a proximal port of the handle.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: September 7, 2021
    Assignee: Medtronic, Inc.
    Inventors: Sean Ward, Rónán Wood, Gwenda Francis, Paula McDonnell, Aram Jamous
  • Patent number: 11083837
    Abstract: A method includes providing a medication delivery vehicle comprising a reservoir with a seal formed thereon and a cantilevered beam micro-machined from a layer of material and coupled to the reservoir, the cantilevered beam comprising a tip for puncturing the seal, applying an electric field to the cantilevered beam that impels the tip forward and causes the tip to break through the seal of the reservoir, and changing the electric field to impel the micro-machined tip backward and thereby release a medication from the reservoir. A computer program product and computer system corresponding to the method are also disclosed.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 10, 2021
    Assignee: International Business Machines Corporation
    Inventors: Ira L. Allen, Gregory J. Boss, Lawrence A. Clevenger, Andrew R. Jones, Kevin C. McConnell, John E. Moore, Jr.
  • Patent number: 10980750
    Abstract: An ingestible pill is provided that includes an enteric coating and a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and (b) needles. The patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least 50% of the needles are coupled to the patch along the inner crease sides. The patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter. Other embodiments are also described.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: April 20, 2021
    Assignee: Alma Therapeutics Ltd.
    Inventors: Yossi Gross, Oz Cabiri
  • Patent number: 10973627
    Abstract: An inner ear fluid circulation system includes an implantable circulation pump that has a pump inlet and a pump outlet both in fluid communication with inner ear fluid of an implanted patient. The circulation pump is configured to drive the inner ear fluid in from the pump inlet and out through the pump outlet. A pump controller is coupled to the circulation pump and one or more sensing elements for measurement of one or more fluid conditions within the inner ear of the implanted patient, and is configured to control operation of the circulation pump as a function of the measured one or more fluid conditions. Also disclosed is a cochlear implant arrangement and a vestibular implant arrangement comprising such a fluid circulation system.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: April 13, 2021
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Marek Polak
  • Patent number: 10973979
    Abstract: A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: April 13, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Firas H. El-Khatib, Edward R. Damiano
  • Patent number: 10940267
    Abstract: A blood glucose control system is configured to modify therapy provide to a subject and determine whether the modified therapy results in a statistically significant improvement in glycemic control. The system obtains glycemic control information resulting from delivery of first therapy using a first value of a control parameter and determines a first effect corresponding to the first therapy. The control parameter is set to a second value that differs from the first value. The system obtains glycemic control information resulting from the delivery of the second therapy using the second value of the control parameter and determines a second effect corresponding to the second therapy. The system can perform a comparative assessment and determine whether the second value for the control parameter results in a statistically significant improvement in glycemic control for the subject.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: March 9, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Edward R. Damiano, Firas H. El-Khatib
  • Patent number: 10925834
    Abstract: This invention relates to novel extended release pharmaceutical compositions of levetiracetam and preparations and characterizations thereof. This invention further relates to using these extended release pharmaceutical compositions of levetiracetam for the treatment of cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: February 23, 2021
    Assignee: AgeneBio, Inc.
    Inventors: Michela Gallagher, Sharon Rosenzweig-Lipson, Elsie Melsopp, Jack Lawrence James
  • Patent number: 10918511
    Abstract: An intragastric balloon device including a deformable material is in an ingestible form for delivery to a stomach of a patient, expands in response to stimuli in the stomach, and degrades within a limited duration (such as 16 hours or some other value between 2 hours and 72 hours) to diminish to passable form in which remains of the intragastric balloon device are passable from the stomach. In an illustrative example, the deformable material is composed of silicone coated with parylene and encloses perfluoropentane fluid that transitions from liquid to gas due to stomach temperature to inflate the balloon in the stomach and occupy space in the stomach until a fuse of methacrylate erodes to unblock a vent conduit to permit escape of the perfluoropentane for deflating the balloon to diminish to passable form.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: February 16, 2021
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Eric Peeters, Peter Smith, Benjamin Krasnow, Peter Massaro
  • Patent number: 10912933
    Abstract: Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 9, 2021
    Assignee: The Regents of the University of California
    Inventors: Pamela Munster, Jim Kiriakis, Hani Sbitany, Scott Thomas
  • Patent number: 10914169
    Abstract: A frequency sensor comprises a surface functionalized with a reactant sensitive to an analyte and a vibration detector coupled to the functional surface to detect a frequency of a fluid having the analyte and located on the functional surface during vibration thereof. The frequency sensor comprises a measurement circuitry coupled to the vibration detector to determine a frequency shift over time of the detected frequency, wherein the frequency shift corresponds to the presence of the analyte which has reacted with the reactant.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: February 9, 2021
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Michael T. Pelletier, Li Gao
  • Patent number: 10881788
    Abstract: A digital biomedical device includes a substrate forming a cavity, a seal formed around the cavity, a lid coupled to the substrate by the seal, a reactive metal structure comprising a plurality of metal layers, wherein the reactive metal structure is a component of at least one of the substrate and the lid, a metal trace configured to initiate a self-propagating reaction between the plurality of metal layers of the reactive metal structure and release contents of the cavity, and a power supply configured to apply an electric current to the metal trace.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 5, 2021
    Assignee: International Business Machines Corporation
    Inventors: Bing Dang, Gregory M Fritz, Eric P Lewandowski, Joana S. B. T. Maria, Bucknell C Webb, Steven L Wright
  • Patent number: 10856907
    Abstract: A method of atraumatic medication pellet delivery using an atraumatic trocar apparatus is described. The atraumatic trocar apparatus includes a cannula and an obturator. The method includes receiving the obturator by the cannula, wherein the obturator passes through the interior passage and exits through the anterior cannula opening so that the obturator anterior rounded tip extends past the anterior cannula end and at least one opening proximate to the anterior rounded tip also extends past the anterior cannula end. The method includes inserting the atraumatic insertion trocar through an incision into subcutaneous tissue along an insertion path to an insertion length. Additionally, the method includes inserting one or more medication pellet into the medication slot of the inserted cannula and delivering the medication pellet(s) through the interior passage of the cannula to a subcutaneous delivery site by inserting the delivery obturator into the posterior opening of the cannula.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: December 8, 2020
    Inventor: Charles P. Virden
  • Patent number: 10842427
    Abstract: An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 24, 2020
    Assignee: Intuity Medical, Inc.
    Inventors: Raul Escutia, Jeffrey L. Emery, Craig M. Litherland
  • Patent number: 10835286
    Abstract: The disclosure relates to a retrievable intrauterine device which includes a recess suitable for containing one or more elements selected from the group that includes an embryo, male and/or female gametes, a fertilized oocyte, a non-fertilized ovule and a combination of the elements. The recess includes an inner wall made of a biocompatible polymer, the inner wall including at least one perforated portion having perforations with dimensions of between 1 pm and 10 pm, and an outer wall covering the inner wall, the outer wall being made of a biocompatible silicone elastomer and including at least one opening opposite said at least one perforated portion of the inner wall. The use of the device relates to the preimplantation development of gametes and/or embryos.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: November 17, 2020
    Assignee: ANECOVA S.A.
    Inventors: Michel Joie, Stéphane Riviere, Julien Grogg
  • Patent number: 10827926
    Abstract: A method for neurological analysis and treatment is described. In one embodiment, a server sends a request to a wearable device for sensor data of a patient. The server receives sensor data from the wearable device, and sends instructions to the wearable device to present a cognitive test based on the sensor data. The server receives from the wearable device, results of the cognitive test, compares the results against a baseline, and determines an assessment of the user. A notification may be sent to the wearable device based on the assessment. A wearable device for use in the analysis and treatment is also described.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: November 10, 2020
    Assignee: Cambridge Cognition Limited
    Inventors: Andrew Blackwell, Jennifer Barnett
  • Patent number: 10821225
    Abstract: Embodiments relate to a cannula that is provided for delivering a substance, such as a medicine (e.g., insulin) to a patient, where the cannula has reduced likelihood of kinking or occlusions when implanted in a patient. The cannula may have a reduced number of stress concentrations along its length, an angled tip and/or a curve in its length. The cannula may include other designs to reduce kinking, such as internal ribbing and/or a slit along its wall.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 3, 2020
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Matthew William Yavorsky, Pablo Vazquez
  • Patent number: 10792430
    Abstract: A free-jet dosing system for administering a fluid into or under the skin having a micropump and a nozzle arranged on the outlet side. The micropump has an inlet and an outlet and is configured to transport a fluid from the inlet to the outlet and to generate a blocking pressure of at least 20 bar at the outlet. The nozzle is configured to output the fluid output at the outlet as a free jet at a fluid pressure so that the fluid of the free jet may be injected into the skin.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: October 6, 2020
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
    Inventors: Martin Richter, Martin Wackerle, Christian Wald
  • Patent number: 10758672
    Abstract: The subject technology is embodied in a method for predicting a delivery rate of a plurality of drugs dispensed by multiple infusion pumps at a delivery point. The method includes receiving one or more operating parameters related to multiple drug pumps and a carrier fluid pump, wherein each of the drug pumps dispenses a drug, and the carrier fluid pump dispenses a carrier fluid. The method also includes determining a delivery rate of a first drug at the delivery point. This can be done by predicting time variation of a concentration of the first drug at the delivery point based on a mathematical model of a mixed flow through a fluid path that terminates at the delivery point. The mixed flow includes the drugs and the carrier fluid. The model includes the operating parameters and a plurality of flow-parameters related to the mathematical model of the mixed flow.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: September 1, 2020
    Assignee: The General Hospital Corporation
    Inventors: Robert A. Peterfreund, Michael Parker, Mark A. Lovich, Nathaniel M. Sims
  • Patent number: 10738315
    Abstract: The invention is directed to recombinant probiotic bacteria, especially for use in the treatment of an inflammatory skin dysfunction, as well as a method for treating an inflammatory skin dysfunction.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: August 11, 2020
    Assignee: Aurealis Oy
    Inventors: Thomas Wirth, Juha Yrjänheikki, Haritha Samaranayake, Dirk Weber, Igor Mierau, Peter Allard Bron, Herwig Bachmann
  • Patent number: 10737015
    Abstract: Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: August 11, 2020
    Assignee: Bigfoot Biomedical, Inc.
    Inventor: Mark C. Estes
  • Patent number: 10675248
    Abstract: An ingestible pill is provided that includes an enteric coating and a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and (b) needles. The patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least 50% of the needles are coupled to the patch along the inner crease sides. The patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter. Other embodiments are also described.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: June 9, 2020
    Assignee: Alma Therapeutics Ltd.
    Inventors: Yossi Gross, Oz Cabiri
  • Patent number: 10664623
    Abstract: A method for chip encryption includes obtaining a fuse value and a trim value of a chip and setting an encryption algorithm, setting the fuse value and the trim value as parameters of the encryption algorithm and obtaining a secret key which is unique for the chip accordingly to the encryption algorithm, and storing the fuse value, the trim value and the secret key in the chip. Since the fuse value and trim value of the chip are unique naturally, the secret key obtained from the same matrix chip for different applications or different matrix chips for the same application are different from each other, thereby increasing expenses and difficulty for crackers to crack the chip and protecting user's intellectual property perfectly.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: May 26, 2020
    Assignee: Guangzhou ZHONO Electronic Technology Co., Ltd.
    Inventors: Bo Wang, Hongcheng Mao, Weihu Duan
  • Patent number: 10603475
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: March 31, 2020
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 10561830
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Patent number: 10537522
    Abstract: The present disclosure provides for brewing apparatus, such as a disposable brewing pod, filter, beverage screen, or tea bag, treated with an oil-based solution comprising a lipid component; an emulsifier; and a pharmaceutical, holistic, or medical component. Brewing apparatus may be sprayed with a spray gun, such as a high volume low pressure spray gun, a precision bottle-top dispenser, or an automatic apparatus configured to apply an oil-based solution to the brewing apparatus. The brewing apparatus may be filled with a product to be brewed and packaged for individual use. The present disclosure additionally provides for a brewed drinkable product produced using brewing apparatus treated with an oil-based solution comprising a lipid component; an emulsifier; and a pharmaceutical, holistic, or medical component. The end product may be a hot or cold product.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: January 21, 2020
    Assignee: GGCC, Inc
    Inventors: Kristy A. Fischer, Christopher M. Haase
  • Patent number: 10518028
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: December 31, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 10508755
    Abstract: Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 17, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yang Liu, Steven L. Wright
  • Patent number: 10500333
    Abstract: Disclosed is a system and a method for determining an injectable amount of bile required for a patient after gallbladder removal. The system comprises a receiving module, a creating module, and a determining module. The receiving module may receive a bile-flow rate, physiological parameters of a patient, and amount of fatty food in an alimentary tract of the patient. Based on these data received, the creating module may create a graph. Further, the determining module may determine a correlation between the bile-flow rate and the amount of fatty food in the alimentary tract based on the graph created. The correlation may be determined corresponding to a normal person and the patient which may be seen by two separate curves on the graph. Further, the determining module may determine an injectable amount of bile required for the patient based on the correlation.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: December 10, 2019
    Assignee: HCL Technologies Limited
    Inventors: Shyam Thangaraju, Siva Sakthivel Sadasivam, Vishal Chaudhary
  • Patent number: 10500354
    Abstract: An atomizer includes a cartridge with a reservoir containing a fluid and a heating system configured to atomize the fluid into a vapor for inhalation. A respiratory indicator is configured to determine an inhalation period and an exhalation period of a patient using the atomizer. The atomizer then increases atomization of the vapor during the inhalation period and decreases atomization of the vapor during the exhalation period. An impedance sensor measures an amount of the fluid in the atomizer and deactivates atomization in response to an indication of a low fluid level.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 10, 2019
    Assignee: SANMINA CORPORATION
    Inventor: Robert Steven Newberry
  • Patent number: 10493049
    Abstract: An applicator-based transdermal drug delivery system (ABTDS) for administration of drugs to a patient to treat ailments in combination with a wide range of topical formulation classes including but not limited to creams, foams, gels, lotions, and ointments is described herein. The transdermal drug delivery system utilizes an applicator that can be in various disk-like shapes and sizes, and that contain the topical formulation in a fixed area, and is applied over the skin of the patient to ensure accurate drug delivery and protect the drug from being rubbed away. Additional features of the applicator include numerous blunt spikes present on its surface that are designed to enhance rate of drug delivery.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: December 3, 2019
    Assignee: NIRACLE LLC
    Inventor: Weiyong Li
  • Patent number: 10485937
    Abstract: Disclosed is a dispensing system. The dispensing system includes a dispensing unit to dispense therapeutic fluid, and a validation mechanism to enable operation of the dispensing unit based, at least in part, on a determination of whether operation of the dispensing device is authorized.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: November 26, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Avihoo P. Keret
  • Patent number: 10456293
    Abstract: Disclosed is an ocular device including a first structure formed of a first material providing a first shape to the ocular device prior to positioning the ocular device on the surface of the eye, a second structure formed of a second, different material having a tubular structure and a lumen through which the first structure extends, and at least one therapeutic agent is dispersed within the second material of the second structure. The first shape of the ocular device conforms to a second, different shape after positioning the ocular device on the surface of the eye. Upon being removed from the eye, the ocular device retains the second shape or changes to a third shape different from both the first shape and the second shape. Related apparatus, systems and method are described.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: October 29, 2019
    Assignee: ForSight Vision5, Inc.
    Inventors: Anne Brody Rubin, Yair Alster, Cary J. Reich
  • Patent number: 10449155
    Abstract: The present invention provides carbonate apatites with a suitable particle size (average particle size and maximum particle size) as well as small variance (?2) of particle sizes. Provided is a method of manufacturing a carbonate apatite, the method comprising the step of incubating a mixture comprising a calcium ion, a phosphate ion, and a hydrocarbon ion, wherein an incubation temperature is 10° C. or lower and an incubation time of 10 minutes or less. Further, a carbonate apatite made by this method (e.g., carbonate apatite with a maximum particle size of 700 nm, average particle size of 30 nm and drug encapsulation rate of 98%, all in nanometer size) is provided.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: October 22, 2019
    Assignee: Medical Corporation Ijunkai
    Inventor: Hiroyuki Nakanishi
  • Patent number: 10434285
    Abstract: An infusion set (101) includes a base (121), a flexible catheter (142) and an introducer needle (134). The flexible catheter (142) is movable from a first catheter position disposed substantially entirely within the base (121) to a second catheter position in which a free end of the flexible catheter (142) is disposed externally of the base (121). The introducer needle (134) is movable between a first introducer needle position disposed substantially entirely within the base (121) and a second introducer needle position in which a free end of the introducer needle (134) is disposed externally of the base (121). An activation button (161) is movable between first and second button positions.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: October 8, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Ryan Schoonmaker, Cole Constantineau
  • Patent number: 10406336
    Abstract: Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: September 10, 2019
    Inventor: Neil S. Davey
  • Patent number: 10398372
    Abstract: The present disclosure provides a method for determining an effect of a drug on pain experienced by a patient. The method comprises providing reference information concerning at least one visible and/or audible feature that is indicative of a level of the pain. The method further comprises capturing information indicative of the at least one visible and/or audible feature, respectively, from the patient comprising observing the patient directly or indirectly after administering the drug to the patient. In addition, the method comprises determining pain indicating information associated with a level of pain experienced by the patient using the captured information. The method also comprises comparing the pain indicating information with the provided reference information to determine the effect of the drug on the pain experienced by the patient.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 3, 2019
    Assignee: ePAT Pty Ltd
    Inventors: Jeff Hughes, Kreshnik Hoti, Mustafa Abdul Wahed Atee
  • Patent number: 10368788
    Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 6, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Axel Scherer, Meisam Honarvar Nazari, Muhammad Mujeeb-U-Rahman, Mehmet Sencan, Arti Gaur
  • Patent number: 10293108
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 21, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventor: Anirban Roy
  • Patent number: 10280310
    Abstract: A monolayer film of nanoparticles can formed from a fluid mixture by combining nanoparticles dispersed in water with a water-miscible organic solvent and a molecular ligand comprising a head group with affinity for the nanoparticle, and introducing the fluid mixture to a substrate in the presence of an air/fluid interface, thereby causing a monolayer film of nanoparticles to form on the substrate. Such monolayers films can include metallic nanoparticles such as gold, and possess substantially uniform spacing over at least a one centimeter length scale. The films are metasurfaces effective to cause a range of linear refractive index of from around unity at 700 nm to 10 at 1500 nm. Such metasurfaces might find utility, for example, as ultrafast (picosecond scale) switches at wavelengths useful for telecommunications.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 7, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jake Fontana, Jawad Naciri, Banahalli R. Ratna, Nicholas A. Charipar, Alberto Piqué
  • Patent number: 10265464
    Abstract: A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: April 23, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Danna Perlman
  • Patent number: 10251836
    Abstract: A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: April 9, 2019
    Assignee: Arstat, Inc.
    Inventor: Arkady Rubin