Controlled Release Therapeutic Device Or System Patents (Class 604/890.1)
  • Patent number: 10603475
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: March 31, 2020
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 10561830
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Patent number: 10537522
    Abstract: The present disclosure provides for brewing apparatus, such as a disposable brewing pod, filter, beverage screen, or tea bag, treated with an oil-based solution comprising a lipid component; an emulsifier; and a pharmaceutical, holistic, or medical component. Brewing apparatus may be sprayed with a spray gun, such as a high volume low pressure spray gun, a precision bottle-top dispenser, or an automatic apparatus configured to apply an oil-based solution to the brewing apparatus. The brewing apparatus may be filled with a product to be brewed and packaged for individual use. The present disclosure additionally provides for a brewed drinkable product produced using brewing apparatus treated with an oil-based solution comprising a lipid component; an emulsifier; and a pharmaceutical, holistic, or medical component. The end product may be a hot or cold product.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: January 21, 2020
    Assignee: GGCC, Inc
    Inventors: Kristy A. Fischer, Christopher M. Haase
  • Patent number: 10518028
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: December 31, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 10508755
    Abstract: Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 17, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yang Liu, Steven L. Wright
  • Patent number: 10500354
    Abstract: An atomizer includes a cartridge with a reservoir containing a fluid and a heating system configured to atomize the fluid into a vapor for inhalation. A respiratory indicator is configured to determine an inhalation period and an exhalation period of a patient using the atomizer. The atomizer then increases atomization of the vapor during the inhalation period and decreases atomization of the vapor during the exhalation period. An impedance sensor measures an amount of the fluid in the atomizer and deactivates atomization in response to an indication of a low fluid level.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 10, 2019
    Assignee: SANMINA CORPORATION
    Inventor: Robert Steven Newberry
  • Patent number: 10500333
    Abstract: Disclosed is a system and a method for determining an injectable amount of bile required for a patient after gallbladder removal. The system comprises a receiving module, a creating module, and a determining module. The receiving module may receive a bile-flow rate, physiological parameters of a patient, and amount of fatty food in an alimentary tract of the patient. Based on these data received, the creating module may create a graph. Further, the determining module may determine a correlation between the bile-flow rate and the amount of fatty food in the alimentary tract based on the graph created. The correlation may be determined corresponding to a normal person and the patient which may be seen by two separate curves on the graph. Further, the determining module may determine an injectable amount of bile required for the patient based on the correlation.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: December 10, 2019
    Assignee: HCL Technologies Limited
    Inventors: Shyam Thangaraju, Siva Sakthivel Sadasivam, Vishal Chaudhary
  • Patent number: 10493049
    Abstract: An applicator-based transdermal drug delivery system (ABTDS) for administration of drugs to a patient to treat ailments in combination with a wide range of topical formulation classes including but not limited to creams, foams, gels, lotions, and ointments is described herein. The transdermal drug delivery system utilizes an applicator that can be in various disk-like shapes and sizes, and that contain the topical formulation in a fixed area, and is applied over the skin of the patient to ensure accurate drug delivery and protect the drug from being rubbed away. Additional features of the applicator include numerous blunt spikes present on its surface that are designed to enhance rate of drug delivery.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: December 3, 2019
    Assignee: NIRACLE LLC
    Inventor: Weiyong Li
  • Patent number: 10485937
    Abstract: Disclosed is a dispensing system. The dispensing system includes a dispensing unit to dispense therapeutic fluid, and a validation mechanism to enable operation of the dispensing unit based, at least in part, on a determination of whether operation of the dispensing device is authorized.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: November 26, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Avihoo P. Keret
  • Patent number: 10456293
    Abstract: Disclosed is an ocular device including a first structure formed of a first material providing a first shape to the ocular device prior to positioning the ocular device on the surface of the eye, a second structure formed of a second, different material having a tubular structure and a lumen through which the first structure extends, and at least one therapeutic agent is dispersed within the second material of the second structure. The first shape of the ocular device conforms to a second, different shape after positioning the ocular device on the surface of the eye. Upon being removed from the eye, the ocular device retains the second shape or changes to a third shape different from both the first shape and the second shape. Related apparatus, systems and method are described.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: October 29, 2019
    Assignee: ForSight Vision5, Inc.
    Inventors: Anne Brody Rubin, Yair Alster, Cary J. Reich
  • Patent number: 10449155
    Abstract: The present invention provides carbonate apatites with a suitable particle size (average particle size and maximum particle size) as well as small variance (?2) of particle sizes. Provided is a method of manufacturing a carbonate apatite, the method comprising the step of incubating a mixture comprising a calcium ion, a phosphate ion, and a hydrocarbon ion, wherein an incubation temperature is 10° C. or lower and an incubation time of 10 minutes or less. Further, a carbonate apatite made by this method (e.g., carbonate apatite with a maximum particle size of 700 nm, average particle size of 30 nm and drug encapsulation rate of 98%, all in nanometer size) is provided.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: October 22, 2019
    Assignee: Medical Corporation Ijunkai
    Inventor: Hiroyuki Nakanishi
  • Patent number: 10434285
    Abstract: An infusion set (101) includes a base (121), a flexible catheter (142) and an introducer needle (134). The flexible catheter (142) is movable from a first catheter position disposed substantially entirely within the base (121) to a second catheter position in which a free end of the flexible catheter (142) is disposed externally of the base (121). The introducer needle (134) is movable between a first introducer needle position disposed substantially entirely within the base (121) and a second introducer needle position in which a free end of the introducer needle (134) is disposed externally of the base (121). An activation button (161) is movable between first and second button positions.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: October 8, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Ryan Schoonmaker, Cole Constantineau
  • Patent number: 10406336
    Abstract: Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: September 10, 2019
    Inventor: Neil S. Davey
  • Patent number: 10398372
    Abstract: The present disclosure provides a method for determining an effect of a drug on pain experienced by a patient. The method comprises providing reference information concerning at least one visible and/or audible feature that is indicative of a level of the pain. The method further comprises capturing information indicative of the at least one visible and/or audible feature, respectively, from the patient comprising observing the patient directly or indirectly after administering the drug to the patient. In addition, the method comprises determining pain indicating information associated with a level of pain experienced by the patient using the captured information. The method also comprises comparing the pain indicating information with the provided reference information to determine the effect of the drug on the pain experienced by the patient.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 3, 2019
    Assignee: ePAT Pty Ltd
    Inventors: Jeff Hughes, Kreshnik Hoti, Mustafa Abdul Wahed Atee
  • Patent number: 10368788
    Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 6, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Axel Scherer, Meisam Honarvar Nazari, Muhammad Mujeeb-U-Rahman, Mehmet Sencan, Arti Gaur
  • Patent number: 10293108
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 21, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventor: Anirban Roy
  • Patent number: 10280310
    Abstract: A monolayer film of nanoparticles can formed from a fluid mixture by combining nanoparticles dispersed in water with a water-miscible organic solvent and a molecular ligand comprising a head group with affinity for the nanoparticle, and introducing the fluid mixture to a substrate in the presence of an air/fluid interface, thereby causing a monolayer film of nanoparticles to form on the substrate. Such monolayers films can include metallic nanoparticles such as gold, and possess substantially uniform spacing over at least a one centimeter length scale. The films are metasurfaces effective to cause a range of linear refractive index of from around unity at 700 nm to 10 at 1500 nm. Such metasurfaces might find utility, for example, as ultrafast (picosecond scale) switches at wavelengths useful for telecommunications.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 7, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jake Fontana, Jawad Naciri, Banahalli R. Ratna, Nicholas A. Charipar, Alberto Piqué
  • Patent number: 10265464
    Abstract: A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: April 23, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Danna Perlman
  • Patent number: 10251836
    Abstract: A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: April 9, 2019
    Assignee: Arstat, Inc.
    Inventor: Arkady Rubin
  • Patent number: 10239236
    Abstract: Microneedle devices have projections that are generally sharp and elongated and designed to disrupt the upper layer of the skin, cause micro-indentations, or pierce the skin. High density arrays are produced using micro-fabrication or micro-molding techniques. The assembly of individual needles does not lend itself to the production of high density arrays. A method of forming microneedle arrays is disclosed which comprises attaching a plurality of microneedles to a substrate, and building up a 2-dimensional microneedle array by wrapping layers of the substrate around a core or folding the layers repeatedly back upon themselves. The arrays are capable of needle densities with a pitch within the range of needle radius plus several micrometers to millimeters.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: March 26, 2019
    Assignee: NDM Technologies Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10226575
    Abstract: Some embodiments of an infusion pump system can employ a number of power management techniques to avoid using substantially excessive power during operation of the pump drive system. Thus, the infusion pump system can draw upon the energy supply in an efficient manner that extends the useful life on the power supply. Furthermore, the infusion pump system can be configured estimate an amount of power remaining to operate the pump system without the requirement of directly detecting the remaining charge on power supply device (e.g., without detecting the remaining charge on a battery). As such, the infusion pump system can readily inform a user of a particular estimated amount of time remaining for medicine dispensing operations.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 12, 2019
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Steve Miller, Ken Mochel, David C. Rich
  • Patent number: 10195409
    Abstract: Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 5, 2019
    Assignee: Corium International, Inc.
    Inventors: Doug Bourne, Ashutosh Shastry, Anthony Le, Parminder Singh
  • Patent number: 10183127
    Abstract: The present invention relates to a pressure reducer for delivering drugs to a patient and the corresponding method of manufacture, said pressure reducer for delivering drugs to a patient comprising: a duct (9) with an inlet (11) and an outlet (13), a first body (1) with a first surface (5), and a second body (3) with a second surface (6) directly contacting the first body (1). One of the surfaces (5,6) has a recess (7) such that a duct (9) is defined between both surfaces. Both bodies are attached to one another by means of a continuous attachment line running on both sides of the duct (9). The method of manufacture comprises a laser welding step in which the first body (1) is welded to the second body (3) by means of a welding seam extending along both sides of the duct.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: January 22, 2019
    Assignee: LEVENTON S.A.U.
    Inventors: Jordi Martín Llorens, Javier Torras Marí
  • Patent number: 10172704
    Abstract: Eyewear is provided including a frame, and a camera connected with the frame, in which the camera is configured to be controlled by a remote controller. The camera may be configured to capture video and/or a photo. The eyewear may include data storage, and the camera may be connected to the data storage. A wrist watch may be configured to act both as a time piece and a controller of the camera. The eyewear may also include a heads up display and/or a video file player. The eyewear may also include an electro-active lens.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: January 8, 2019
    Assignee: e-Vision Smart Optics, Inc.
    Inventors: Ronald D. Blum, William Kokonaski, Dwight P. Duston
  • Patent number: 10102926
    Abstract: Example embodiments of a system, apparatus, computer readable media, and method are disclosed for improving clinical and financial outcomes for a healthcare provider The example embodiments may be used for aggregating data corresponding to care for a group of patients by at least one healthcare provider, generating a statistical model based on the aggregated data, periodically determining a current value for the treatment parameter associated with care of a patient provided by a healthcare provider, and causing treatment to be administered to the patient in response to applying the statistical model to determine that the current value for the treatment parameter is associated with an adverse outcome.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: October 16, 2018
    Assignee: SENTRY DATA SYSTEMS, INC.
    Inventor: Travis Leonardi
  • Patent number: 10099004
    Abstract: A portable medical apparatus for administering a fluid drug in doses, including a first housing including a reservoir unit with an outlet into a fluid path for conducting the drug, a second housing including a conveying unit for dispensing the drug from the reservoir unit in doses and a suitable controller for controlling the conveying unit, an adaptor including a coupling structure for receiving the first housing and the second housing and an attaching structure for extra-corporeally carrying the adaptor on a patient, wherein the conveying unit and the reservoir unit can be joined together to form an integrated mechanical and fluidic unit, and coupled to and decoupled from at least two differently configured adaptors, wherein at least one of the adaptors is configured to be directly attached to the surface of the skin and at least one of the adaptors is configured to be worn on or carried by an article of clothing or a wearing system (e.g., a belt).
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 16, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Marco De Polo
  • Patent number: 10058650
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: August 28, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 9993209
    Abstract: According to an embodiment of the present invention, a system dynamically monitors a patient's physiological condition and location information to generate an alarm signal to enable the patient to timely administer a health substance. Initially, the system monitors location information of a health substance and the patient and physiological information of the patient. A processor in the system determines a predicted time when the patient may attain a physiological condition for receiving the health substance and may further determine a transit time for the patient to travel to a location of the health substance. Based on the predicted and transit times, the system issues an alarm signal to the patient prior to the predicted time. Embodiments of the present invention further include a method and computer program product for monitoring a patient's physiological condition and location information to generate an alarm signal in substantially the same manner described above.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: June 12, 2018
    Assignee: International Business Machines Corporation
    Inventors: Kanako Fujitani, Mariko Ishige, Yusuke Nishitani, Yutaka Oishi, Tatsuya Sobue, Masayuki Yamana
  • Patent number: 9949921
    Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Agigma, Inc.
    Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
  • Patent number: 9943647
    Abstract: A pharmaceutical injection device comprises a main body case (2); a pharmaceutical syringe mounting component (3) that is provided inside the main body case (2) and onto which a pharmaceutical syringe (4) is mounted; a piston (5) provided movably with respect to the pharmaceutical syringe (4) mounted onto the pharmaceutical syringe mounting component (3); a drive mechanism (6) for driving the piston (5); a memory (46) that stores a preset pharmaceutical injection schedule; and a controller (7) that resets a current pharmaceutical dose by comparing a planned cumulative pharmaceutical dose, which is a planned cumulative amount of pharmaceutical injected up to the last time on the basis of the pharmaceutical injection schedule stored in the memory, and an actual cumulative pharmaceutical dose, which is a cumulative amount of pharmaceutical actually injected up to the last time.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: April 17, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Yasutaka Mukai, Seiji Kikuchi, Tsuguhiro Kondoh
  • Patent number: 9943228
    Abstract: A functional skin patch having a first surface and a second surface opposite the first surface is provided. The functional skin patch includes a functional unit having a thermo harvester and an antenna unit. The thermo harvester has a first terminal thermally connected to the first surface and a second terminal. The antenna unit has a first terminal thermally connected to the second terminal of the thermo harvester and a second terminal thermally connected to the second surface. The antenna unit has a stacked layer structure including, in this sequence, a metal layer thermally connected to the second terminal of the thermo harvester, a ferrite layer thermally connected to the metal layer, and an antenna layer thermally connected to the ferrite layer.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: April 17, 2018
    Assignee: Infineon Technologies AG
    Inventors: Robert Kappel, Thomas Herndl, Gerald Holweg, Walther Pachler
  • Patent number: 9919104
    Abstract: The protrusion relates to a device comprising a main body case having a sensor mounting component, a measurement component that is connected to the sensor mounting component, a controller that is connected to this measurement component, and a display component that is connected to this controller. A communication component that is connected to the controller communicates pharmaceutical injection information and non-pharmaceutical-injection information to a specific pump. The controller performs communication at a first output when communicating non-pharmaceutical-injection information to the pump, and performs communication at a second output that is smaller than the first output when communicating pharmaceutical injection information to the pump.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: March 20, 2018
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventor: Akiyoshi Ohzawa
  • Patent number: 9919103
    Abstract: Containment devices and methods of manufacture and assembly are provided. In an embodiment, the containment device includes an elongated microchip element comprising one or more containment reservoirs that are configured to be electrically activated to open. The containment device also include an elongated electronic printed circuit board (PCB) comprising a substrate. The elongated PCB comprises a first side on which one or more electronic components are fixed and an opposed second side on which the elongated microchip element is fixed in electrical connection to the one or more electronic components. Further, the containment device includes an elongated housing fixed to the elongated PCB. The elongated housing is configured to hermetically seal the one or more electronic components of the elongated PCB within the elongated housing.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: March 20, 2018
    Assignee: MICROCHIPS BIOTECH, INC.
    Inventor: Robert Farra
  • Patent number: 9913698
    Abstract: Disclosed is a medicine ingestion state management method capable of objectively managing medicine ingestion states of patients. The medicine ingestion state management method involves an operation of prescribing medicine (10) encapsulating, together with a medicament, a medicine information transmitting unit (20) having a function of transmitting medicine information capable of specifying a type and a quantity of the medicament to each individual patient, and an operation of grasping the medicine ingestion state of each patient by collecting the medicine information from each medicine information transmitting unit (20) in each patient.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: March 13, 2018
    Assignee: FUJITSU LIMITED
    Inventors: Hitoshi Kimura, Morihito Notani
  • Patent number: 9884011
    Abstract: In one aspect, an ingestible, electrical device, comprises a substrate comprising a reservoir that is configured to hold one or more substances; a first film covering the reservoir, wherein the first film is at least partially metallic; a charge storage system connected to the first film, the charge storage system configured to deliver a transient electrochemical potential to the first film; wherein the first film is configured to prevent exposure of the substance to an aqueous environment in an organism, while the charge storage system delivers the transient electrochemical potential to the first film; and wherein the first film is configured for dissolution to expose the one or more substances to the aqueous environment in the organism, after the charge storage system stops delivering the transient electrochemical potential to the first film.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: February 6, 2018
    Assignee: Carnegie Mellon University
    Inventor: Christopher J. Bettinger
  • Patent number: 9855420
    Abstract: One aspect relates to a medical implant, for example, implantable stimulation electrode, having a tight substrate and a porous contact region. One aspect also relates to a lead of a cardiac pacemaker having an implantable stimulation electrode and to a method for manufacturing a medical implant, for example, an implantable stimulation electrode. A medical implant according to one aspect is characterized in that the implant includes a sintered body with graduated porosity.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: January 2, 2018
    Assignee: Heraeus Deutschland GmbH & Co. KG
    Inventors: Heiko Specht, Andreas Reisinger, Goran Pavlovic
  • Patent number: 9855256
    Abstract: Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 2, 2018
    Assignee: Omeros Corporation
    Inventors: Gregory A. Demopulos, Jeffrey M. Herz, Wayne R. Gombotz, Hui-rong Shen
  • Patent number: 9855011
    Abstract: A measurement device includes a sensor attached to a biosensor which includes a reagent that selectively responds to a specific analyte in a biological fluid, an analyte measurer that measures a concentration of the specific analyte with a biosensor, and a motion measurer that measures a motion level of the measurement device. A recorder records the concentration of the analyte and motion information, and a controller connects the analyte measurer and the motion measurer and controls the analyte measurer and the recorder based on the controller motion information. The controller includes a damage determiner that judges whether or not the measurement device is damaged, based on the motion level.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: January 2, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Noriyoshi Terashima, Masataka Nadaoka
  • Patent number: 9840789
    Abstract: A nanoporous metal structure is made by etching a metal alloy structure of two or more metals. Less than all of the metals are selectively removed (e.g., dissolved in solution) from the alloy in the presence of an alternating voltage profile, for example, a periodic voltage profile. The resulting nanoporous metal structure, having pore openings of about 20 nm to about 500 nm in diameter and a purity of at least about 70%, can be further treated to alter some or all of the structure, and/or to add, remove and/or modify properties thereof.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: December 12, 2017
    Assignee: CITY UNIVERSITY OF HONG KONG
    Inventors: Jie Zhang, Yang Yang Li, Jian Lu
  • Patent number: 9837191
    Abstract: Embodiments are directed to a method for manufacturing a product comprising: establishing, by a computing device comprising a processor, at least one parameter of a particular instance of a component to be used in the product, adapting, by the computing device, a baseline model of the component based on the at least one parameter to accommodate use of the particular instance of the component, growing a structure based on the adapted model to accommodate the particular instance of the component using an additive manufacturing technique, coupling the structure to the particular instance of the component, growing an electrical harness by using additive printing to establish an electrical cable, and assembling the product by coupling the electrical harness to the particular instance of the component.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: December 5, 2017
    Assignee: RAYTHEON COMPANY
    Inventor: Rigel Q. Woida-O'Brien
  • Patent number: 9827356
    Abstract: A catheter pump is disclosed herein. The catheter pump can include an elongate catheter body and an impeller assembly coupled to a distal portion of the elongate catheter body. The impeller assembly can comprise an impeller configured to rotate during operation of the catheter pump. A tube can extend through at least portions of the elongate catheter body and the impeller assembly. The tube can extend distal the impeller and can be configured to remain in the portions of the elongate catheter body and the impeller assembly during operation of the catheter pump.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 28, 2017
    Assignee: TC1 LLC
    Inventors: Paul F. Muller, Keif M. Fitzgerald, Richard L. Keenan
  • Patent number: 9820884
    Abstract: A device for delivering a treatment medium to an eye includes a first body portion configured to be removably inserted and secured in an opening of the eye, and a second body portion supported by the first body portion. At least the second body portion includes a treatment medium, and a coating having an opening through which the treatment medium elutes out of the device.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 21, 2017
    Assignee: Mati Therapeutics Inc.
    Inventor: Eliot Lazar
  • Patent number: 9808608
    Abstract: A delivery device including a substrate formed in a coil comprising a plurality of loops, an active agent deposited between an inner surface and an outer surface of the substrate formed in the coil, and a pair of end caps, each end cap disposed on a corresponding end of the coil.
    Type: Grant
    Filed: November 16, 2014
    Date of Patent: November 7, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Bucknell C. Webb
  • Patent number: 9808577
    Abstract: The present invention relates to a device, system and a method for optimizing syringe based drug delivery profile with a treatment element and in particular, to such a device, system and method in which optimization is based on a plurality of data that directly and/or indirectly affect the optimization of the drug delivery profile. The device facilitating syringe based drug delivery, by optimizing drug delivery of the injected drug, records user's activity, and data relative to drug injections, comprising a disposable unit configured for a single use period and a rechargeable reusable unit having electronics comprising a sensor module.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: November 7, 2017
    Assignee: Insuline Medical Ltd.
    Inventors: Ron Nagar, Gabriel Bitton, Elisha Amir, Moshe Fadlun
  • Patent number: 9721409
    Abstract: A wearable device may include a sensor system capable of obtaining physiological from a user's body. Some wearable devices may include a substance delivery system. A sensor system of a wearable device may include at least one “bio-assurance sensor” capable of obtaining biometric data that may be used to identify a user. For example, the bio-assurance sensor may be used to ensure that the wearable device is not removed from the user's body and/or placed on or in another user's body. In some examples, the wearable device may be used with a second device, such as a smart phone, that includes at least one “authentication sensor,” such as a fingerprint sensor, that also may be used to identify a user. However, in some implementations the wearable device may include at least one authentication sensor.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: August 1, 2017
    Assignee: QUALCOMM Incorporated
    Inventors: Muhammed Ibrahim Sezan, John Keith Schneider, Kenneth Kaskoun, Eugene Dantsker
  • Patent number: 9717896
    Abstract: Systems and methods are described for implementing or deploying one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 1, 2017
    Assignee: GEARBOX, LLC
    Inventors: Bran Ferren, Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9675812
    Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: June 13, 2017
    Assignee: ELWHA LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Eric C. Leuthardt, Gary L. McKnight, Lowell L. Wood, Jr.
  • Patent number: 9656020
    Abstract: According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: May 23, 2017
    Assignee: IMPERIAL INNOVATIONS LIMITED
    Inventors: Pantelis Georgiou, Kok Thay Lim, Christofer Toumazou
  • Patent number: 9636460
    Abstract: A pneumatic autoinjector that, once activated, automatically mixes at least two components in a pre-filled chamber and then ejects the mixture in a manner suitable for medicament injection. The mixable components may be a dry/wet combination (e.g., powder and solvent), wet/wet combination (e.g., two pre-diluted medicaments), wet/gas combination (e.g., chemical A and gas B), or gas/gas combination. In some embodiments, autoinjectors made in accordance with the teachings of the present disclosure may automatically perform a sequence comprising thorough medicament mixing (e.g., reconstitution of a dried medicament with solvent), an optional pause to enhance medicament dissolution or suspension, optional needle insertion into the patient (not required in needle-free embodiments), medicament injection into the patient, and optional needle retraction for safe storage.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: May 2, 2017
    Assignee: Creare LLC
    Inventors: Michael D. Jaeger, Mark C. Bagley, Roger W. Hill, Sandra J. Graveson, Robert T. Payne
  • Patent number: 9622979
    Abstract: The present invention relates to a multilayered coated tablet comprising at least three layers, i.e., first, second and third layer wherein the first and third layers contain at least one active pharmaceutical ingredient and the second layer is either a placebo or an immediate-release drug layer. Further, the tablet has a delayed-release coating, wherein the coating may contain one or more pore-forming agents and/or orifices on one or both sides. Furthermore, it may contain an immediate-release layer of the drug over the delayed-release coating layer. The present invention further relates to processes for preparing such a multilayered coated tablet.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 18, 2017
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Murali Krishna Bhavarisetti, Kumaravel Vivek, Sreekanth Narravula, Romi Barat Singh