Controlled Release Therapeutic Device Or System Patents (Class 604/890.1)
  • Patent number: 10980750
    Abstract: An ingestible pill is provided that includes an enteric coating and a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and (b) needles. The patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least 50% of the needles are coupled to the patch along the inner crease sides. The patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter. Other embodiments are also described.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: April 20, 2021
    Assignee: Alma Therapeutics Ltd.
    Inventors: Yossi Gross, Oz Cabiri
  • Patent number: 10973627
    Abstract: An inner ear fluid circulation system includes an implantable circulation pump that has a pump inlet and a pump outlet both in fluid communication with inner ear fluid of an implanted patient. The circulation pump is configured to drive the inner ear fluid in from the pump inlet and out through the pump outlet. A pump controller is coupled to the circulation pump and one or more sensing elements for measurement of one or more fluid conditions within the inner ear of the implanted patient, and is configured to control operation of the circulation pump as a function of the measured one or more fluid conditions. Also disclosed is a cochlear implant arrangement and a vestibular implant arrangement comprising such a fluid circulation system.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: April 13, 2021
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventor: Marek Polak
  • Patent number: 10973979
    Abstract: A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: April 13, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Firas H. El-Khatib, Edward R. Damiano
  • Patent number: 10940267
    Abstract: A blood glucose control system is configured to modify therapy provide to a subject and determine whether the modified therapy results in a statistically significant improvement in glycemic control. The system obtains glycemic control information resulting from delivery of first therapy using a first value of a control parameter and determines a first effect corresponding to the first therapy. The control parameter is set to a second value that differs from the first value. The system obtains glycemic control information resulting from the delivery of the second therapy using the second value of the control parameter and determines a second effect corresponding to the second therapy. The system can perform a comparative assessment and determine whether the second value for the control parameter results in a statistically significant improvement in glycemic control for the subject.
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: March 9, 2021
    Assignee: Beta Bionics, Inc.
    Inventors: Edward R. Damiano, Firas H. El-Khatib
  • Patent number: 10925834
    Abstract: This invention relates to novel extended release pharmaceutical compositions of levetiracetam and preparations and characterizations thereof. This invention further relates to using these extended release pharmaceutical compositions of levetiracetam for the treatment of cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: February 23, 2021
    Assignee: AgeneBio, Inc.
    Inventors: Michela Gallagher, Sharon Rosenzweig-Lipson, Elsie Melsopp, Jack Lawrence James
  • Patent number: 10918511
    Abstract: An intragastric balloon device including a deformable material is in an ingestible form for delivery to a stomach of a patient, expands in response to stimuli in the stomach, and degrades within a limited duration (such as 16 hours or some other value between 2 hours and 72 hours) to diminish to passable form in which remains of the intragastric balloon device are passable from the stomach. In an illustrative example, the deformable material is composed of silicone coated with parylene and encloses perfluoropentane fluid that transitions from liquid to gas due to stomach temperature to inflate the balloon in the stomach and occupy space in the stomach until a fuse of methacrylate erodes to unblock a vent conduit to permit escape of the perfluoropentane for deflating the balloon to diminish to passable form.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: February 16, 2021
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Eric Peeters, Peter Smith, Benjamin Krasnow, Peter Massaro
  • Patent number: 10914169
    Abstract: A frequency sensor comprises a surface functionalized with a reactant sensitive to an analyte and a vibration detector coupled to the functional surface to detect a frequency of a fluid having the analyte and located on the functional surface during vibration thereof. The frequency sensor comprises a measurement circuitry coupled to the vibration detector to determine a frequency shift over time of the detected frequency, wherein the frequency shift corresponds to the presence of the analyte which has reacted with the reactant.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: February 9, 2021
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Michael T. Pelletier, Li Gao
  • Patent number: 10912933
    Abstract: Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: February 9, 2021
    Assignee: The Regents of the University of California
    Inventors: Pamela Munster, Jim Kiriakis, Hani Sbitany, Scott Thomas
  • Patent number: 10881788
    Abstract: A digital biomedical device includes a substrate forming a cavity, a seal formed around the cavity, a lid coupled to the substrate by the seal, a reactive metal structure comprising a plurality of metal layers, wherein the reactive metal structure is a component of at least one of the substrate and the lid, a metal trace configured to initiate a self-propagating reaction between the plurality of metal layers of the reactive metal structure and release contents of the cavity, and a power supply configured to apply an electric current to the metal trace.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 5, 2021
    Assignee: International Business Machines Corporation
    Inventors: Bing Dang, Gregory M Fritz, Eric P Lewandowski, Joana S. B. T. Maria, Bucknell C Webb, Steven L Wright
  • Patent number: 10856907
    Abstract: A method of atraumatic medication pellet delivery using an atraumatic trocar apparatus is described. The atraumatic trocar apparatus includes a cannula and an obturator. The method includes receiving the obturator by the cannula, wherein the obturator passes through the interior passage and exits through the anterior cannula opening so that the obturator anterior rounded tip extends past the anterior cannula end and at least one opening proximate to the anterior rounded tip also extends past the anterior cannula end. The method includes inserting the atraumatic insertion trocar through an incision into subcutaneous tissue along an insertion path to an insertion length. Additionally, the method includes inserting one or more medication pellet into the medication slot of the inserted cannula and delivering the medication pellet(s) through the interior passage of the cannula to a subcutaneous delivery site by inserting the delivery obturator into the posterior opening of the cannula.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: December 8, 2020
    Inventor: Charles P. Virden
  • Patent number: 10842427
    Abstract: An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: November 24, 2020
    Assignee: Intuity Medical, Inc.
    Inventors: Raul Escutia, Jeffrey L. Emery, Craig M. Litherland
  • Patent number: 10835286
    Abstract: The disclosure relates to a retrievable intrauterine device which includes a recess suitable for containing one or more elements selected from the group that includes an embryo, male and/or female gametes, a fertilized oocyte, a non-fertilized ovule and a combination of the elements. The recess includes an inner wall made of a biocompatible polymer, the inner wall including at least one perforated portion having perforations with dimensions of between 1 pm and 10 pm, and an outer wall covering the inner wall, the outer wall being made of a biocompatible silicone elastomer and including at least one opening opposite said at least one perforated portion of the inner wall. The use of the device relates to the preimplantation development of gametes and/or embryos.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: November 17, 2020
    Assignee: ANECOVA S.A.
    Inventors: Michel Joie, Stéphane Riviere, Julien Grogg
  • Patent number: 10827926
    Abstract: A method for neurological analysis and treatment is described. In one embodiment, a server sends a request to a wearable device for sensor data of a patient. The server receives sensor data from the wearable device, and sends instructions to the wearable device to present a cognitive test based on the sensor data. The server receives from the wearable device, results of the cognitive test, compares the results against a baseline, and determines an assessment of the user. A notification may be sent to the wearable device based on the assessment. A wearable device for use in the analysis and treatment is also described.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: November 10, 2020
    Assignee: Cambridge Cognition Limited
    Inventors: Andrew Blackwell, Jennifer Barnett
  • Patent number: 10821225
    Abstract: Embodiments relate to a cannula that is provided for delivering a substance, such as a medicine (e.g., insulin) to a patient, where the cannula has reduced likelihood of kinking or occlusions when implanted in a patient. The cannula may have a reduced number of stress concentrations along its length, an angled tip and/or a curve in its length. The cannula may include other designs to reduce kinking, such as internal ribbing and/or a slit along its wall.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 3, 2020
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Matthew William Yavorsky, Pablo Vazquez
  • Patent number: 10792430
    Abstract: A free-jet dosing system for administering a fluid into or under the skin having a micropump and a nozzle arranged on the outlet side. The micropump has an inlet and an outlet and is configured to transport a fluid from the inlet to the outlet and to generate a blocking pressure of at least 20 bar at the outlet. The nozzle is configured to output the fluid output at the outlet as a free jet at a fluid pressure so that the fluid of the free jet may be injected into the skin.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: October 6, 2020
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
    Inventors: Martin Richter, Martin Wackerle, Christian Wald
  • Patent number: 10758672
    Abstract: The subject technology is embodied in a method for predicting a delivery rate of a plurality of drugs dispensed by multiple infusion pumps at a delivery point. The method includes receiving one or more operating parameters related to multiple drug pumps and a carrier fluid pump, wherein each of the drug pumps dispenses a drug, and the carrier fluid pump dispenses a carrier fluid. The method also includes determining a delivery rate of a first drug at the delivery point. This can be done by predicting time variation of a concentration of the first drug at the delivery point based on a mathematical model of a mixed flow through a fluid path that terminates at the delivery point. The mixed flow includes the drugs and the carrier fluid. The model includes the operating parameters and a plurality of flow-parameters related to the mathematical model of the mixed flow.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: September 1, 2020
    Assignee: The General Hospital Corporation
    Inventors: Robert A. Peterfreund, Michael Parker, Mark A. Lovich, Nathaniel M. Sims
  • Patent number: 10738315
    Abstract: The invention is directed to recombinant probiotic bacteria, especially for use in the treatment of an inflammatory skin dysfunction, as well as a method for treating an inflammatory skin dysfunction.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: August 11, 2020
    Assignee: Aurealis Oy
    Inventors: Thomas Wirth, Juha Yrjänheikki, Haritha Samaranayake, Dirk Weber, Igor Mierau, Peter Allard Bron, Herwig Bachmann
  • Patent number: 10737015
    Abstract: Some embodiments an infusion pump system can be used to determine a user's total insulin load (TIL) that provides an accurate indication of the insulin previously delivered to the user's body which has not yet acted. In particular embodiments, the TIL can account for both the bolus deliveries and the basal deliveries that have occurred over a period of time. Such information may be useful, for example, when the infusion pump is operated in conjunction with a continuous glucose monitoring device.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: August 11, 2020
    Assignee: Bigfoot Biomedical, Inc.
    Inventor: Mark C. Estes
  • Patent number: 10675248
    Abstract: An ingestible pill is provided that includes an enteric coating and a medication-delivery device, which includes (a) a patch having upper and lower surfaces that face in generally opposite directions, and (b) needles. The patch is disposed within the enteric coating, folded so as to define one or more creases, which define respective inner and outer crease sides, wherein at least 50% of the needles are coupled to the patch along the inner crease sides. The patch is configured to assume, after the enteric coating dissolves, an expanded shape, in which the patch has an outer perimeter. Other embodiments are also described.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: June 9, 2020
    Assignee: Alma Therapeutics Ltd.
    Inventors: Yossi Gross, Oz Cabiri
  • Patent number: 10664623
    Abstract: A method for chip encryption includes obtaining a fuse value and a trim value of a chip and setting an encryption algorithm, setting the fuse value and the trim value as parameters of the encryption algorithm and obtaining a secret key which is unique for the chip accordingly to the encryption algorithm, and storing the fuse value, the trim value and the secret key in the chip. Since the fuse value and trim value of the chip are unique naturally, the secret key obtained from the same matrix chip for different applications or different matrix chips for the same application are different from each other, thereby increasing expenses and difficulty for crackers to crack the chip and protecting user's intellectual property perfectly.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: May 26, 2020
    Assignee: Guangzhou ZHONO Electronic Technology Co., Ltd.
    Inventors: Bo Wang, Hongcheng Mao, Weihu Duan
  • Patent number: 10603475
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: March 31, 2020
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 10561830
    Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: February 18, 2020
    Assignee: The Johns Hopkins University
    Inventors: Chao-Wei Hwang, Zhiyong Xia, Virginia E. Bogdan, Jeffrey A. Brinker, Gary Gerstenblith, Peter V. Johnston, Steven P. Schulman, Gordon Tomaselli, Robert G. Weiss
  • Patent number: 10537522
    Abstract: The present disclosure provides for brewing apparatus, such as a disposable brewing pod, filter, beverage screen, or tea bag, treated with an oil-based solution comprising a lipid component; an emulsifier; and a pharmaceutical, holistic, or medical component. Brewing apparatus may be sprayed with a spray gun, such as a high volume low pressure spray gun, a precision bottle-top dispenser, or an automatic apparatus configured to apply an oil-based solution to the brewing apparatus. The brewing apparatus may be filled with a product to be brewed and packaged for individual use. The present disclosure additionally provides for a brewed drinkable product produced using brewing apparatus treated with an oil-based solution comprising a lipid component; an emulsifier; and a pharmaceutical, holistic, or medical component. The end product may be a hot or cold product.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: January 21, 2020
    Assignee: GGCC, Inc
    Inventors: Kristy A. Fischer, Christopher M. Haase
  • Patent number: 10518028
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: December 31, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 10508755
    Abstract: Embodiments of the present invention are directed to a liquid delivery apparatus. A non-limiting example of the apparatus includes a substrate including a cavity formed in a surface of the substrate. The apparatus can also include a membrane disposed on the surface of the substrate covering an opening of the cavity. The apparatus can also include a hydrophobic layer disposed on the membrane. The apparatus can also include a seal disposed between the membrane and the substrate, wherein the seal surrounds the opening of the cavity. The apparatus can also include an electrode layer coupled to the membrane.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 17, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yang Liu, Steven L. Wright
  • Patent number: 10500354
    Abstract: An atomizer includes a cartridge with a reservoir containing a fluid and a heating system configured to atomize the fluid into a vapor for inhalation. A respiratory indicator is configured to determine an inhalation period and an exhalation period of a patient using the atomizer. The atomizer then increases atomization of the vapor during the inhalation period and decreases atomization of the vapor during the exhalation period. An impedance sensor measures an amount of the fluid in the atomizer and deactivates atomization in response to an indication of a low fluid level.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: December 10, 2019
    Assignee: SANMINA CORPORATION
    Inventor: Robert Steven Newberry
  • Patent number: 10500333
    Abstract: Disclosed is a system and a method for determining an injectable amount of bile required for a patient after gallbladder removal. The system comprises a receiving module, a creating module, and a determining module. The receiving module may receive a bile-flow rate, physiological parameters of a patient, and amount of fatty food in an alimentary tract of the patient. Based on these data received, the creating module may create a graph. Further, the determining module may determine a correlation between the bile-flow rate and the amount of fatty food in the alimentary tract based on the graph created. The correlation may be determined corresponding to a normal person and the patient which may be seen by two separate curves on the graph. Further, the determining module may determine an injectable amount of bile required for the patient based on the correlation.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: December 10, 2019
    Assignee: HCL Technologies Limited
    Inventors: Shyam Thangaraju, Siva Sakthivel Sadasivam, Vishal Chaudhary
  • Patent number: 10493049
    Abstract: An applicator-based transdermal drug delivery system (ABTDS) for administration of drugs to a patient to treat ailments in combination with a wide range of topical formulation classes including but not limited to creams, foams, gels, lotions, and ointments is described herein. The transdermal drug delivery system utilizes an applicator that can be in various disk-like shapes and sizes, and that contain the topical formulation in a fixed area, and is applied over the skin of the patient to ensure accurate drug delivery and protect the drug from being rubbed away. Additional features of the applicator include numerous blunt spikes present on its surface that are designed to enhance rate of drug delivery.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: December 3, 2019
    Assignee: NIRACLE LLC
    Inventor: Weiyong Li
  • Patent number: 10485937
    Abstract: Disclosed is a dispensing system. The dispensing system includes a dispensing unit to dispense therapeutic fluid, and a validation mechanism to enable operation of the dispensing unit based, at least in part, on a determination of whether operation of the dispensing device is authorized.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: November 26, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Avihoo P. Keret
  • Patent number: 10456293
    Abstract: Disclosed is an ocular device including a first structure formed of a first material providing a first shape to the ocular device prior to positioning the ocular device on the surface of the eye, a second structure formed of a second, different material having a tubular structure and a lumen through which the first structure extends, and at least one therapeutic agent is dispersed within the second material of the second structure. The first shape of the ocular device conforms to a second, different shape after positioning the ocular device on the surface of the eye. Upon being removed from the eye, the ocular device retains the second shape or changes to a third shape different from both the first shape and the second shape. Related apparatus, systems and method are described.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: October 29, 2019
    Assignee: ForSight Vision5, Inc.
    Inventors: Anne Brody Rubin, Yair Alster, Cary J. Reich
  • Patent number: 10449155
    Abstract: The present invention provides carbonate apatites with a suitable particle size (average particle size and maximum particle size) as well as small variance (?2) of particle sizes. Provided is a method of manufacturing a carbonate apatite, the method comprising the step of incubating a mixture comprising a calcium ion, a phosphate ion, and a hydrocarbon ion, wherein an incubation temperature is 10° C. or lower and an incubation time of 10 minutes or less. Further, a carbonate apatite made by this method (e.g., carbonate apatite with a maximum particle size of 700 nm, average particle size of 30 nm and drug encapsulation rate of 98%, all in nanometer size) is provided.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: October 22, 2019
    Assignee: Medical Corporation Ijunkai
    Inventor: Hiroyuki Nakanishi
  • Patent number: 10434285
    Abstract: An infusion set (101) includes a base (121), a flexible catheter (142) and an introducer needle (134). The flexible catheter (142) is movable from a first catheter position disposed substantially entirely within the base (121) to a second catheter position in which a free end of the flexible catheter (142) is disposed externally of the base (121). The introducer needle (134) is movable between a first introducer needle position disposed substantially entirely within the base (121) and a second introducer needle position in which a free end of the introducer needle (134) is disposed externally of the base (121). An activation button (161) is movable between first and second button positions.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: October 8, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Ryan Schoonmaker, Cole Constantineau
  • Patent number: 10406336
    Abstract: Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: September 10, 2019
    Inventor: Neil S. Davey
  • Patent number: 10398372
    Abstract: The present disclosure provides a method for determining an effect of a drug on pain experienced by a patient. The method comprises providing reference information concerning at least one visible and/or audible feature that is indicative of a level of the pain. The method further comprises capturing information indicative of the at least one visible and/or audible feature, respectively, from the patient comprising observing the patient directly or indirectly after administering the drug to the patient. In addition, the method comprises determining pain indicating information associated with a level of pain experienced by the patient using the captured information. The method also comprises comparing the pain indicating information with the provided reference information to determine the effect of the drug on the pain experienced by the patient.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 3, 2019
    Assignee: ePAT Pty Ltd
    Inventors: Jeff Hughes, Kreshnik Hoti, Mustafa Abdul Wahed Atee
  • Patent number: 10368788
    Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 6, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Axel Scherer, Meisam Honarvar Nazari, Muhammad Mujeeb-U-Rahman, Mehmet Sencan, Arti Gaur
  • Patent number: 10293108
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 21, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventor: Anirban Roy
  • Patent number: 10280310
    Abstract: A monolayer film of nanoparticles can formed from a fluid mixture by combining nanoparticles dispersed in water with a water-miscible organic solvent and a molecular ligand comprising a head group with affinity for the nanoparticle, and introducing the fluid mixture to a substrate in the presence of an air/fluid interface, thereby causing a monolayer film of nanoparticles to form on the substrate. Such monolayers films can include metallic nanoparticles such as gold, and possess substantially uniform spacing over at least a one centimeter length scale. The films are metasurfaces effective to cause a range of linear refractive index of from around unity at 700 nm to 10 at 1500 nm. Such metasurfaces might find utility, for example, as ultrafast (picosecond scale) switches at wavelengths useful for telecommunications.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 7, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jake Fontana, Jawad Naciri, Banahalli R. Ratna, Nicholas A. Charipar, Alberto Piqué
  • Patent number: 10265464
    Abstract: A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: April 23, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Danna Perlman
  • Patent number: 10251836
    Abstract: A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: April 9, 2019
    Assignee: Arstat, Inc.
    Inventor: Arkady Rubin
  • Patent number: 10239236
    Abstract: Microneedle devices have projections that are generally sharp and elongated and designed to disrupt the upper layer of the skin, cause micro-indentations, or pierce the skin. High density arrays are produced using micro-fabrication or micro-molding techniques. The assembly of individual needles does not lend itself to the production of high density arrays. A method of forming microneedle arrays is disclosed which comprises attaching a plurality of microneedles to a substrate, and building up a 2-dimensional microneedle array by wrapping layers of the substrate around a core or folding the layers repeatedly back upon themselves. The arrays are capable of needle densities with a pitch within the range of needle radius plus several micrometers to millimeters.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: March 26, 2019
    Assignee: NDM Technologies Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10226575
    Abstract: Some embodiments of an infusion pump system can employ a number of power management techniques to avoid using substantially excessive power during operation of the pump drive system. Thus, the infusion pump system can draw upon the energy supply in an efficient manner that extends the useful life on the power supply. Furthermore, the infusion pump system can be configured estimate an amount of power remaining to operate the pump system without the requirement of directly detecting the remaining charge on power supply device (e.g., without detecting the remaining charge on a battery). As such, the infusion pump system can readily inform a user of a particular estimated amount of time remaining for medicine dispensing operations.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 12, 2019
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Steve Miller, Ken Mochel, David C. Rich
  • Patent number: 10195409
    Abstract: Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 5, 2019
    Assignee: Corium International, Inc.
    Inventors: Doug Bourne, Ashutosh Shastry, Anthony Le, Parminder Singh
  • Patent number: 10183127
    Abstract: The present invention relates to a pressure reducer for delivering drugs to a patient and the corresponding method of manufacture, said pressure reducer for delivering drugs to a patient comprising: a duct (9) with an inlet (11) and an outlet (13), a first body (1) with a first surface (5), and a second body (3) with a second surface (6) directly contacting the first body (1). One of the surfaces (5,6) has a recess (7) such that a duct (9) is defined between both surfaces. Both bodies are attached to one another by means of a continuous attachment line running on both sides of the duct (9). The method of manufacture comprises a laser welding step in which the first body (1) is welded to the second body (3) by means of a welding seam extending along both sides of the duct.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: January 22, 2019
    Assignee: LEVENTON S.A.U.
    Inventors: Jordi Martín Llorens, Javier Torras Marí
  • Patent number: 10172704
    Abstract: Eyewear is provided including a frame, and a camera connected with the frame, in which the camera is configured to be controlled by a remote controller. The camera may be configured to capture video and/or a photo. The eyewear may include data storage, and the camera may be connected to the data storage. A wrist watch may be configured to act both as a time piece and a controller of the camera. The eyewear may also include a heads up display and/or a video file player. The eyewear may also include an electro-active lens.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: January 8, 2019
    Assignee: e-Vision Smart Optics, Inc.
    Inventors: Ronald D. Blum, William Kokonaski, Dwight P. Duston
  • Patent number: 10102926
    Abstract: Example embodiments of a system, apparatus, computer readable media, and method are disclosed for improving clinical and financial outcomes for a healthcare provider The example embodiments may be used for aggregating data corresponding to care for a group of patients by at least one healthcare provider, generating a statistical model based on the aggregated data, periodically determining a current value for the treatment parameter associated with care of a patient provided by a healthcare provider, and causing treatment to be administered to the patient in response to applying the statistical model to determine that the current value for the treatment parameter is associated with an adverse outcome.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: October 16, 2018
    Assignee: SENTRY DATA SYSTEMS, INC.
    Inventor: Travis Leonardi
  • Patent number: 10099004
    Abstract: A portable medical apparatus for administering a fluid drug in doses, including a first housing including a reservoir unit with an outlet into a fluid path for conducting the drug, a second housing including a conveying unit for dispensing the drug from the reservoir unit in doses and a suitable controller for controlling the conveying unit, an adaptor including a coupling structure for receiving the first housing and the second housing and an attaching structure for extra-corporeally carrying the adaptor on a patient, wherein the conveying unit and the reservoir unit can be joined together to form an integrated mechanical and fluidic unit, and coupled to and decoupled from at least two differently configured adaptors, wherein at least one of the adaptors is configured to be directly attached to the surface of the skin and at least one of the adaptors is configured to be worn on or carried by an article of clothing or a wearing system (e.g., a belt).
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 16, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Marco De Polo
  • Patent number: 10058650
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: August 28, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 9993209
    Abstract: According to an embodiment of the present invention, a system dynamically monitors a patient's physiological condition and location information to generate an alarm signal to enable the patient to timely administer a health substance. Initially, the system monitors location information of a health substance and the patient and physiological information of the patient. A processor in the system determines a predicted time when the patient may attain a physiological condition for receiving the health substance and may further determine a transit time for the patient to travel to a location of the health substance. Based on the predicted and transit times, the system issues an alarm signal to the patient prior to the predicted time. Embodiments of the present invention further include a method and computer program product for monitoring a patient's physiological condition and location information to generate an alarm signal in substantially the same manner described above.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: June 12, 2018
    Assignee: International Business Machines Corporation
    Inventors: Kanako Fujitani, Mariko Ishige, Yusuke Nishitani, Yutaka Oishi, Tatsuya Sobue, Masayuki Yamana
  • Patent number: 9949921
    Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Agigma, Inc.
    Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
  • Patent number: 9943647
    Abstract: A pharmaceutical injection device comprises a main body case (2); a pharmaceutical syringe mounting component (3) that is provided inside the main body case (2) and onto which a pharmaceutical syringe (4) is mounted; a piston (5) provided movably with respect to the pharmaceutical syringe (4) mounted onto the pharmaceutical syringe mounting component (3); a drive mechanism (6) for driving the piston (5); a memory (46) that stores a preset pharmaceutical injection schedule; and a controller (7) that resets a current pharmaceutical dose by comparing a planned cumulative pharmaceutical dose, which is a planned cumulative amount of pharmaceutical injected up to the last time on the basis of the pharmaceutical injection schedule stored in the memory, and an actual cumulative pharmaceutical dose, which is a cumulative amount of pharmaceutical actually injected up to the last time.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: April 17, 2018
    Assignee: PANASONIC HEALTHCARE HOLDINGS CO., LTD.
    Inventors: Yasutaka Mukai, Seiji Kikuchi, Tsuguhiro Kondoh