Controlled Release Therapeutic Device Or System Patents (Class 604/890.1)
  • Patent number: 10293108
    Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver a bolus amount of fluid influencing a physiological condition in a body of a user involves identifying, based on measurement values for the physiological condition, a residual value for the physiological condition resulting from the bolus amount of the fluid and determining an updated ratio for a subsequent bolus by adjusting an initial ratio influencing the bolus amount to compensate for the residual value. The updated ratio may be stored in a data storage element for use in determining a subsequent bolus amount in lieu of the initial ratio value.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: May 21, 2019
    Assignee: Medtronic MiniMed, Inc.
    Inventor: Anirban Roy
  • Patent number: 10280310
    Abstract: A monolayer film of nanoparticles can formed from a fluid mixture by combining nanoparticles dispersed in water with a water-miscible organic solvent and a molecular ligand comprising a head group with affinity for the nanoparticle, and introducing the fluid mixture to a substrate in the presence of an air/fluid interface, thereby causing a monolayer film of nanoparticles to form on the substrate. Such monolayers films can include metallic nanoparticles such as gold, and possess substantially uniform spacing over at least a one centimeter length scale. The films are metasurfaces effective to cause a range of linear refractive index of from around unity at 700 nm to 10 at 1500 nm. Such metasurfaces might find utility, for example, as ultrafast (picosecond scale) switches at wavelengths useful for telecommunications.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 7, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jake Fontana, Jawad Naciri, Banahalli R. Ratna, Nicholas A. Charipar, Alberto Piqué
  • Patent number: 10265464
    Abstract: A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: April 23, 2019
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Ofer Yodfat, Danna Perlman
  • Patent number: 10251836
    Abstract: A method and intravaginal drug delivery device for reducing size of endometrial implants in a female in need thereof are provided. The method includes administering intravaginally to the female a therapeutically effective amount of an active agent, wherein the agent is delivered on a delivery device directly to the endometrial implants, wherein said amount is able to significantly reduce the size of endometrial implants, wherein the active agent is any one of selective progesterone receptor modulator (SPRM), an anti-progestin agent, and an anti-progestational agent.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: April 9, 2019
    Assignee: Arstat, Inc.
    Inventor: Arkady Rubin
  • Patent number: 10239236
    Abstract: Microneedle devices have projections that are generally sharp and elongated and designed to disrupt the upper layer of the skin, cause micro-indentations, or pierce the skin. High density arrays are produced using micro-fabrication or micro-molding techniques. The assembly of individual needles does not lend itself to the production of high density arrays. A method of forming microneedle arrays is disclosed which comprises attaching a plurality of microneedles to a substrate, and building up a 2-dimensional microneedle array by wrapping layers of the substrate around a core or folding the layers repeatedly back upon themselves. The arrays are capable of needle densities with a pitch within the range of needle radius plus several micrometers to millimeters.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: March 26, 2019
    Assignee: NDM Technologies Limited
    Inventor: Dewan Fazlul Hoque Chowdhury
  • Patent number: 10226575
    Abstract: Some embodiments of an infusion pump system can employ a number of power management techniques to avoid using substantially excessive power during operation of the pump drive system. Thus, the infusion pump system can draw upon the energy supply in an efficient manner that extends the useful life on the power supply. Furthermore, the infusion pump system can be configured estimate an amount of power remaining to operate the pump system without the requirement of directly detecting the remaining charge on power supply device (e.g., without detecting the remaining charge on a battery). As such, the infusion pump system can readily inform a user of a particular estimated amount of time remaining for medicine dispensing operations.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 12, 2019
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Steve Miller, Ken Mochel, David C. Rich
  • Patent number: 10195409
    Abstract: Applicators for a microprojection array capable of multiple impacts and methods of using the applicators are described.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: February 5, 2019
    Assignee: Corium International, Inc.
    Inventors: Doug Bourne, Ashutosh Shastry, Anthony Le, Parminder Singh
  • Patent number: 10183127
    Abstract: The present invention relates to a pressure reducer for delivering drugs to a patient and the corresponding method of manufacture, said pressure reducer for delivering drugs to a patient comprising: a duct (9) with an inlet (11) and an outlet (13), a first body (1) with a first surface (5), and a second body (3) with a second surface (6) directly contacting the first body (1). One of the surfaces (5,6) has a recess (7) such that a duct (9) is defined between both surfaces. Both bodies are attached to one another by means of a continuous attachment line running on both sides of the duct (9). The method of manufacture comprises a laser welding step in which the first body (1) is welded to the second body (3) by means of a welding seam extending along both sides of the duct.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: January 22, 2019
    Assignee: LEVENTON S.A.U.
    Inventors: Jordi Martín Llorens, Javier Torras Marí
  • Patent number: 10172704
    Abstract: Eyewear is provided including a frame, and a camera connected with the frame, in which the camera is configured to be controlled by a remote controller. The camera may be configured to capture video and/or a photo. The eyewear may include data storage, and the camera may be connected to the data storage. A wrist watch may be configured to act both as a time piece and a controller of the camera. The eyewear may also include a heads up display and/or a video file player. The eyewear may also include an electro-active lens.
    Type: Grant
    Filed: August 3, 2015
    Date of Patent: January 8, 2019
    Assignee: e-Vision Smart Optics, Inc.
    Inventors: Ronald D. Blum, William Kokonaski, Dwight P. Duston
  • Patent number: 10102926
    Abstract: Example embodiments of a system, apparatus, computer readable media, and method are disclosed for improving clinical and financial outcomes for a healthcare provider The example embodiments may be used for aggregating data corresponding to care for a group of patients by at least one healthcare provider, generating a statistical model based on the aggregated data, periodically determining a current value for the treatment parameter associated with care of a patient provided by a healthcare provider, and causing treatment to be administered to the patient in response to applying the statistical model to determine that the current value for the treatment parameter is associated with an adverse outcome.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: October 16, 2018
    Inventor: Travis Leonardi
  • Patent number: 10099004
    Abstract: A portable medical apparatus for administering a fluid drug in doses, including a first housing including a reservoir unit with an outlet into a fluid path for conducting the drug, a second housing including a conveying unit for dispensing the drug from the reservoir unit in doses and a suitable controller for controlling the conveying unit, an adaptor including a coupling structure for receiving the first housing and the second housing and an attaching structure for extra-corporeally carrying the adaptor on a patient, wherein the conveying unit and the reservoir unit can be joined together to form an integrated mechanical and fluidic unit, and coupled to and decoupled from at least two differently configured adaptors, wherein at least one of the adaptors is configured to be directly attached to the surface of the skin and at least one of the adaptors is configured to be worn on or carried by an article of clothing or a wearing system (e.g., a belt).
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 16, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Marco De Polo
  • Patent number: 10058650
    Abstract: A basal hub for attaching to an infusion base is disclosed. The hub includes a fluid reservoir and pressure actuating device. A septum portion of the reservoir is configured to be opened by a flow cannula that is in fluid communication with an infusion cannula of the infusion base, when the basal hub is attached to the infusion base. The pressure actuating device applies pressure to the fluid reservoir, such that when the septum portion of the fluid reservoir is pierced by the by the flow cannula, liquid stored in the fluid reservoir is released from the fluid reservoir into the infusion cannula of the infusion base via the flow cannula. The basal hub is configured to deliver a basal dose of insulin during periods of inactivity, such as during sleep time.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: August 28, 2018
    Assignee: Becton, Dickinson and Company
    Inventors: Gary M. Searle, Charles G. Hwang
  • Patent number: 9993209
    Abstract: According to an embodiment of the present invention, a system dynamically monitors a patient's physiological condition and location information to generate an alarm signal to enable the patient to timely administer a health substance. Initially, the system monitors location information of a health substance and the patient and physiological information of the patient. A processor in the system determines a predicted time when the patient may attain a physiological condition for receiving the health substance and may further determine a transit time for the patient to travel to a location of the health substance. Based on the predicted and transit times, the system issues an alarm signal to the patient prior to the predicted time. Embodiments of the present invention further include a method and computer program product for monitoring a patient's physiological condition and location information to generate an alarm signal in substantially the same manner described above.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: June 12, 2018
    Assignee: International Business Machines Corporation
    Inventors: Kanako Fujitani, Mariko Ishige, Yusuke Nishitani, Yutaka Oishi, Tatsuya Sobue, Masayuki Yamana
  • Patent number: 9949921
    Abstract: The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 24, 2018
    Assignee: Agigma, Inc.
    Inventors: Nevenka Golubovic-Liakopoulos, Bhavdeep Shah, Erik Andersen
  • Patent number: 9943228
    Abstract: A functional skin patch having a first surface and a second surface opposite the first surface is provided. The functional skin patch includes a functional unit having a thermo harvester and an antenna unit. The thermo harvester has a first terminal thermally connected to the first surface and a second terminal. The antenna unit has a first terminal thermally connected to the second terminal of the thermo harvester and a second terminal thermally connected to the second surface. The antenna unit has a stacked layer structure including, in this sequence, a metal layer thermally connected to the second terminal of the thermo harvester, a ferrite layer thermally connected to the metal layer, and an antenna layer thermally connected to the ferrite layer.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: April 17, 2018
    Assignee: Infineon Technologies AG
    Inventors: Robert Kappel, Thomas Herndl, Gerald Holweg, Walther Pachler
  • Patent number: 9943647
    Abstract: A pharmaceutical injection device comprises a main body case (2); a pharmaceutical syringe mounting component (3) that is provided inside the main body case (2) and onto which a pharmaceutical syringe (4) is mounted; a piston (5) provided movably with respect to the pharmaceutical syringe (4) mounted onto the pharmaceutical syringe mounting component (3); a drive mechanism (6) for driving the piston (5); a memory (46) that stores a preset pharmaceutical injection schedule; and a controller (7) that resets a current pharmaceutical dose by comparing a planned cumulative pharmaceutical dose, which is a planned cumulative amount of pharmaceutical injected up to the last time on the basis of the pharmaceutical injection schedule stored in the memory, and an actual cumulative pharmaceutical dose, which is a cumulative amount of pharmaceutical actually injected up to the last time.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: April 17, 2018
    Inventors: Yasutaka Mukai, Seiji Kikuchi, Tsuguhiro Kondoh
  • Patent number: 9919103
    Abstract: Containment devices and methods of manufacture and assembly are provided. In an embodiment, the containment device includes an elongated microchip element comprising one or more containment reservoirs that are configured to be electrically activated to open. The containment device also include an elongated electronic printed circuit board (PCB) comprising a substrate. The elongated PCB comprises a first side on which one or more electronic components are fixed and an opposed second side on which the elongated microchip element is fixed in electrical connection to the one or more electronic components. Further, the containment device includes an elongated housing fixed to the elongated PCB. The elongated housing is configured to hermetically seal the one or more electronic components of the elongated PCB within the elongated housing.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: March 20, 2018
    Inventor: Robert Farra
  • Patent number: 9919104
    Abstract: The protrusion relates to a device comprising a main body case having a sensor mounting component, a measurement component that is connected to the sensor mounting component, a controller that is connected to this measurement component, and a display component that is connected to this controller. A communication component that is connected to the controller communicates pharmaceutical injection information and non-pharmaceutical-injection information to a specific pump. The controller performs communication at a first output when communicating non-pharmaceutical-injection information to the pump, and performs communication at a second output that is smaller than the first output when communicating pharmaceutical injection information to the pump.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: March 20, 2018
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventor: Akiyoshi Ohzawa
  • Patent number: 9913698
    Abstract: Disclosed is a medicine ingestion state management method capable of objectively managing medicine ingestion states of patients. The medicine ingestion state management method involves an operation of prescribing medicine (10) encapsulating, together with a medicament, a medicine information transmitting unit (20) having a function of transmitting medicine information capable of specifying a type and a quantity of the medicament to each individual patient, and an operation of grasping the medicine ingestion state of each patient by collecting the medicine information from each medicine information transmitting unit (20) in each patient.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: March 13, 2018
    Inventors: Hitoshi Kimura, Morihito Notani
  • Patent number: 9884011
    Abstract: In one aspect, an ingestible, electrical device, comprises a substrate comprising a reservoir that is configured to hold one or more substances; a first film covering the reservoir, wherein the first film is at least partially metallic; a charge storage system connected to the first film, the charge storage system configured to deliver a transient electrochemical potential to the first film; wherein the first film is configured to prevent exposure of the substance to an aqueous environment in an organism, while the charge storage system delivers the transient electrochemical potential to the first film; and wherein the first film is configured for dissolution to expose the one or more substances to the aqueous environment in the organism, after the charge storage system stops delivering the transient electrochemical potential to the first film.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: February 6, 2018
    Assignee: Carnegie Mellon University
    Inventor: Christopher J. Bettinger
  • Patent number: 9855420
    Abstract: One aspect relates to a medical implant, for example, implantable stimulation electrode, having a tight substrate and a porous contact region. One aspect also relates to a lead of a cardiac pacemaker having an implantable stimulation electrode and to a method for manufacturing a medical implant, for example, an implantable stimulation electrode. A medical implant according to one aspect is characterized in that the implant includes a sintered body with graduated porosity.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: January 2, 2018
    Assignee: Heraeus Deutschland GmbH & Co. KG
    Inventors: Heiko Specht, Andreas Reisinger, Goran Pavlovic
  • Patent number: 9855256
    Abstract: Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 2, 2018
    Assignee: Omeros Corporation
    Inventors: Gregory A. Demopulos, Jeffrey M. Herz, Wayne R. Gombotz, Hui-rong Shen
  • Patent number: 9855011
    Abstract: A measurement device includes a sensor attached to a biosensor which includes a reagent that selectively responds to a specific analyte in a biological fluid, an analyte measurer that measures a concentration of the specific analyte with a biosensor, and a motion measurer that measures a motion level of the measurement device. A recorder records the concentration of the analyte and motion information, and a controller connects the analyte measurer and the motion measurer and controls the analyte measurer and the recorder based on the controller motion information. The controller includes a damage determiner that judges whether or not the measurement device is damaged, based on the motion level.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: January 2, 2018
    Inventors: Noriyoshi Terashima, Masataka Nadaoka
  • Patent number: 9840789
    Abstract: A nanoporous metal structure is made by etching a metal alloy structure of two or more metals. Less than all of the metals are selectively removed (e.g., dissolved in solution) from the alloy in the presence of an alternating voltage profile, for example, a periodic voltage profile. The resulting nanoporous metal structure, having pore openings of about 20 nm to about 500 nm in diameter and a purity of at least about 70%, can be further treated to alter some or all of the structure, and/or to add, remove and/or modify properties thereof.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: December 12, 2017
    Inventors: Jie Zhang, Yang Yang Li, Jian Lu
  • Patent number: 9837191
    Abstract: Embodiments are directed to a method for manufacturing a product comprising: establishing, by a computing device comprising a processor, at least one parameter of a particular instance of a component to be used in the product, adapting, by the computing device, a baseline model of the component based on the at least one parameter to accommodate use of the particular instance of the component, growing a structure based on the adapted model to accommodate the particular instance of the component using an additive manufacturing technique, coupling the structure to the particular instance of the component, growing an electrical harness by using additive printing to establish an electrical cable, and assembling the product by coupling the electrical harness to the particular instance of the component.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: December 5, 2017
    Inventor: Rigel Q. Woida-O'Brien
  • Patent number: 9827356
    Abstract: A catheter pump is disclosed herein. The catheter pump can include an elongate catheter body and an impeller assembly coupled to a distal portion of the elongate catheter body. The impeller assembly can comprise an impeller configured to rotate during operation of the catheter pump. A tube can extend through at least portions of the elongate catheter body and the impeller assembly. The tube can extend distal the impeller and can be configured to remain in the portions of the elongate catheter body and the impeller assembly during operation of the catheter pump.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 28, 2017
    Assignee: TC1 LLC
    Inventors: Paul F. Muller, Keif M. Fitzgerald, Richard L. Keenan
  • Patent number: 9820884
    Abstract: A device for delivering a treatment medium to an eye includes a first body portion configured to be removably inserted and secured in an opening of the eye, and a second body portion supported by the first body portion. At least the second body portion includes a treatment medium, and a coating having an opening through which the treatment medium elutes out of the device.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 21, 2017
    Assignee: Mati Therapeutics Inc.
    Inventor: Eliot Lazar
  • Patent number: 9808608
    Abstract: A delivery device including a substrate formed in a coil comprising a plurality of loops, an active agent deposited between an inner surface and an outer surface of the substrate formed in the coil, and a pair of end caps, each end cap disposed on a corresponding end of the coil.
    Type: Grant
    Filed: November 16, 2014
    Date of Patent: November 7, 2017
    Inventor: Bucknell C. Webb
  • Patent number: 9808577
    Abstract: The present invention relates to a device, system and a method for optimizing syringe based drug delivery profile with a treatment element and in particular, to such a device, system and method in which optimization is based on a plurality of data that directly and/or indirectly affect the optimization of the drug delivery profile. The device facilitating syringe based drug delivery, by optimizing drug delivery of the injected drug, records user's activity, and data relative to drug injections, comprising a disposable unit configured for a single use period and a rechargeable reusable unit having electronics comprising a sensor module.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: November 7, 2017
    Assignee: Insuline Medical Ltd.
    Inventors: Ron Nagar, Gabriel Bitton, Elisha Amir, Moshe Fadlun
  • Patent number: 9721409
    Abstract: A wearable device may include a sensor system capable of obtaining physiological from a user's body. Some wearable devices may include a substance delivery system. A sensor system of a wearable device may include at least one “bio-assurance sensor” capable of obtaining biometric data that may be used to identify a user. For example, the bio-assurance sensor may be used to ensure that the wearable device is not removed from the user's body and/or placed on or in another user's body. In some examples, the wearable device may be used with a second device, such as a smart phone, that includes at least one “authentication sensor,” such as a fingerprint sensor, that also may be used to identify a user. However, in some implementations the wearable device may include at least one authentication sensor.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: August 1, 2017
    Assignee: QUALCOMM Incorporated
    Inventors: Muhammed Ibrahim Sezan, John Keith Schneider, Kenneth Kaskoun, Eugene Dantsker
  • Patent number: 9717896
    Abstract: Systems and methods are described for implementing or deploying one or more capture components configured to accelerate a decrease in a local concentration of one or more therapeutic structures along a downstream portion of a vasculature and one or more dispensation components configured to release the one or more therapeutic structures into an upstream portion of the vasculature.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 1, 2017
    Assignee: GEARBOX, LLC
    Inventors: Bran Ferren, Roderick A. Hyde, Muriel Y. Ishikawa, Eric C. Leuthardt, Dennis J. Rivet, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 9675812
    Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: June 13, 2017
    Assignee: ELWHA LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Eric C. Leuthardt, Gary L. McKnight, Lowell L. Wood, Jr.
  • Patent number: 9656020
    Abstract: According to a first aspect of the present invention there is provided a controller for controlling a glucagon pump. The controller comprises an input 8 for receiving an input signal indicative of a measured blood glucose concentration, an output 9 for providing a pulsed glucagon pump drive signal, each pulse being arranged to cause a glucagon pump to deliver a volume of glucagon, and a processing unit 10 for setting the pulse frequency of the pump drive signal in dependence upon the input signal, such that when the input signal indicates that the measured blood glucose concentration is above a threshold concentration the pulse frequency is zero and when the input signal indicates that the measured blood glucose concentration is below the threshold concentration the pulse frequency is increased as the measured blood glucose concentration decreases.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: May 23, 2017
    Inventors: Pantelis Georgiou, Kok Thay Lim, Christofer Toumazou
  • Patent number: 9636460
    Abstract: A pneumatic autoinjector that, once activated, automatically mixes at least two components in a pre-filled chamber and then ejects the mixture in a manner suitable for medicament injection. The mixable components may be a dry/wet combination (e.g., powder and solvent), wet/wet combination (e.g., two pre-diluted medicaments), wet/gas combination (e.g., chemical A and gas B), or gas/gas combination. In some embodiments, autoinjectors made in accordance with the teachings of the present disclosure may automatically perform a sequence comprising thorough medicament mixing (e.g., reconstitution of a dried medicament with solvent), an optional pause to enhance medicament dissolution or suspension, optional needle insertion into the patient (not required in needle-free embodiments), medicament injection into the patient, and optional needle retraction for safe storage.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: May 2, 2017
    Assignee: Creare LLC
    Inventors: Michael D. Jaeger, Mark C. Bagley, Roger W. Hill, Sandra J. Graveson, Robert T. Payne
  • Patent number: 9622979
    Abstract: The present invention relates to a multilayered coated tablet comprising at least three layers, i.e., first, second and third layer wherein the first and third layers contain at least one active pharmaceutical ingredient and the second layer is either a placebo or an immediate-release drug layer. Further, the tablet has a delayed-release coating, wherein the coating may contain one or more pore-forming agents and/or orifices on one or both sides. Furthermore, it may contain an immediate-release layer of the drug over the delayed-release coating layer. The present invention further relates to processes for preparing such a multilayered coated tablet.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 18, 2017
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Murali Krishna Bhavarisetti, Kumaravel Vivek, Sreekanth Narravula, Romi Barat Singh
  • Patent number: 9622690
    Abstract: A measurement device includes a housing that has an attached biosensor that includes a reagent selectively responding to a specific analyte in a biological fluid, and is configured so as to be carried by a user, an analyte measurer that measures a concentration of the specific analyte with a biosensor, and a motion measurer that measures a motion level of the housing. A living activity level calculator calculates a living activity level of the user based on the motion level measured by the motion measurer, a recorder records the living activity level calculated by the living activity level calculator, and a controller associates the concentration of the specific analyte measured by the analyte measurer with an event of living activity of the user, estimated based on the living activity level recorded in the recorder, and records them in the recorder.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: April 18, 2017
    Inventors: Noriyoshi Terashima, Masataka Nadaoka
  • Patent number: 9579512
    Abstract: An implantable medical device includes circuitry for generating and delivering electrical stimulation therapy. A power source is included in the implantable medical device for storage of the energy for the stimulation therapy. Techniques and circuits are provided for minimizing energy losses associated with the storage of the stimulation therapy energy. The implantable medical device circuitry includes charging circuitry that is operated in at least a first mode and a second mode, such that the charging circuit is operable in one of the at least first and second modes based on whether an intrinsic cardiac event is detected. The charging circuit is operable to withhold charging the output capacitor in the first mode until a given cardiac cycle elapses without a sensed intrinsic cardiac event.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 28, 2017
    Assignee: Medtronic, Inc.
    Inventor: Wade M Demmer
  • Patent number: 9566248
    Abstract: An encased-pellet tablet for an active pharmaceutical ingredient comprises an excipient layer on the outside and an inner core that is surrounded by the excipient layer. The inner core contains a plurality of coated pellets, and the coated pellets comprise pellets of the active pharmaceutical ingredient coated with a pellet coating. The excipient layer contains from about 1 wt. % to about 20 wt. % of at least one cushioning agent selected from polyhydroxyl compounds. A method for manufacturing the encased-pellet tablets involves compressing an excipient material to form a first layer; compressing a plurality of coated pellets containing an API on said first layer to form an inner core thereon and compressing additional excipient material around an exposed portion of said inner core thereby surrounding said inner core with excipient material.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: February 14, 2017
    Assignee: R.P. Scherer Technologies, LLC
    Inventors: Harry G. Cocolas, Christin P. Hollis
  • Patent number: 9526825
    Abstract: A drug infusion system includes a first infusion pump including a processor and a user interface in operable communication with the processor, and a second infusion pump, wherein the processor of the first infusion pump (i) enables an operator to make a selection using the user interface, the selection specifying a combination of a plurality of drugs to be delivered to a patient using the first and second infusion pumps, and (ii) commands the first infusion pump to deliver one or more drug of the combination to the patient and the second infusion pump to deliver one or more drug of the combination to the patient.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: December 27, 2016
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Natalie McTaggart, James P. Martucci
  • Patent number: 9457176
    Abstract: Implantable devices and methods for controlled drug delivery are provided. The device includes a device structure deformable between a retention shape and a low profile shape for deployment in the bladder of a patient and has a drug reservoir lumen in which a drug formulation is housed. The device also includes a buoyancy retention portion, which includes a volume of entrapped air or a gas-generating or effervescent powder which will generate a volume of entrapped air following contact with urine in the bladder. The buoyancy retention portion may include a water permeable and/or biodegradable wall, which can release the entrapped air following drug release, to cause the device to sink into the bladder neck to facilitate device expulsion without the need for a device retrieval medical procedure.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: October 4, 2016
    Assignee: TARIS Biomedical LLC
    Inventors: Heejin Lee, Hong Linh Ho Duc
  • Patent number: 9460135
    Abstract: The current document is directed to automated electronic testing, optimization, and/or analysis systems that perform testing that results in non-binomial experimental results that are processed by using efficient and robust processing methods. In one implementation, efficient and robust processing methods are employed to process non-binomial results produced from single-factor tests. In a second implementation, robust and computationally efficient processing methods are employed to analyze non-binomial results from multi-factor/multi-level tests.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: October 4, 2016
    Assignee: Webtrends Inc.
    Inventors: Vladimir Brayman, Lihui Shi, Spencer Wood
  • Patent number: 9439743
    Abstract: There is a concern that a mechanical switch could be switched OFF due to movement of a body in which the switch is embedded. If the switch is switched OFF after being embedded, it is difficult to switch the switch back ON. Provided is a fluid delivery device that is used by being embedded within a body, including a fluid delivery mechanism for discharging fluid from a reservoir that contains the fluid to outside of the reservoir; a sending and receiving section that sends and receives information relating to control of the fluid delivery mechanism to and from an external apparatus; a power supply section that supplies power to at least one of the fluid delivery device and the sending and receiving section; and a mechanical switch that is capable of changing a supply path of the power only from a cutoff state to a conductive state.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: September 13, 2016
    Inventors: Ryosuke Ogihara, Susumu Kobayashi
  • Patent number: 9439582
    Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: September 13, 2016
    Assignee: Proteus Digital Health, Inc.
    Inventors: Jeffrey Berkman, Mark Zdeblick, Patricia Johnson, Hooman Hafezi, Jonathan Withrington
  • Patent number: 9421351
    Abstract: An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: August 23, 2016
    Inventors: Joseph C. Trautman, Lorin Olson
  • Patent number: 9381288
    Abstract: Various embodiments of a fluid handling system are disclosed herein. For example, the fluid handling system can include a catheter assembly and a console configured to control the operation of the catheter assembly. A removable interface member can be configured to provide fluid and electrical communication between the catheter assembly and the console.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: July 5, 2016
    Inventors: Alan Schenck, Michael L. Green, Keif M. Fitzgerald, Paul F. Muller, Joseph P. Sullivan, Keith Schubert, Peter W. Bristol, Jeffrey Paul Mills, Paul C. Leonard, Richard L. Keenan
  • Patent number: 9378333
    Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver insulin, a processor, and a user interface including a bistable display. A display element of the bistable display is placed in one of two stable orientations upon application of a biasing voltage and stays in the stable orientation when the biasing voltage is removed. The processor includes a display module configured to display a non-blank reversion display screen on the bistable display when no input is received at the user interface after a specified time duration, and to recurrently change the reversion display screen until input is received at the user interface.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: June 28, 2016
    Assignee: Smiths Medical ASD, Inc.
    Inventors: Michael Blomquist, Timothy Bresina, Gail Bynum, Michael Welsch
  • Patent number: 9372404
    Abstract: The invention provides an organic film composition comprises (A) a heat-decomposable polymer, (B) an organic solvent, and (C) an aromatic ring containing resin, with the weight reduction rate of (A) the heat-decomposable polymer from 30° C. to 250° C. being 40% or more by mass. There can be provided an organic film composition having not only a high dry etching resistance but also an excellent filling-up or flattening characteristics.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: June 21, 2016
    Inventors: Takeru Watanabe, Seiichiro Tachibana, Toshihiko Fujii, Kazumi Noda, Toshiharu Yano, Takeshi Kinsho
  • Patent number: 9358033
    Abstract: A minimally invasive skin treatment system includes a platform having a recessed area on its bottom and one or more injection ports orthogonal to its top, each injection port including a through-hole to the recessed area. The system includes an injection device including a needle slidably disposed in a selective port such that the needle passes into the recessed area and percutaneously through a dermis disposed within the recessed area. A nozzle is configured to discharge a fluid at a high pressure in a direction orthogonal to an axis of the needle and parallel to the top of the platform to cut create a plane of dissection within the subcutaneous tissue.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: June 7, 2016
    Assignee: Ulthera, Inc.
    Inventors: Sowmya Ballakur, Robert L. Clark, III, James E. Chomas, Ben F. Brian, III, David M. Clapper
  • Patent number: 9333282
    Abstract: The invention relates to a wound-stimulating unit comprising a wound-stimulating device for use in combination with a vacuum assisted closure. The closure comprises a hydrophilic body to be placed on a wound surface, a cover sealing the hydrophilic body and a skin portion surrounding the wound surface, and a vacuum system for generating an underpressure in a closure space limited by the wound surface, the skin portion surrounding the wound surface and the cover. Further, the wound-stimulating device comprises a connector provided with an intermediate channel structure having an input section and multiple output sections, the device further comprising a pressure system for supplying wound stimulating agents to the input section of the intermediate channel structure.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: May 10, 2016
    Assignee: KCI Medical Resources
    Inventor: Rene Remmelt Willie Johan Van der Hulst
  • Patent number: 9327076
    Abstract: An electronically and remotely controlled pill (500) or medicament delivery system is provided. The pill (500) includes a housing (102); a medicament reservoir (104) for storing a medicament; an electronically controlled release valve or hatch (106) for dispensing one or more medicaments stored in the medicament reservoir (104) while traversing the gastrointestinal tract; control and timing circuitry (108) for opening and closing the valve (106); and a battery (109). The control and timing circuitry (108) opens an closes the valve (106) throughout a dispensing time period in accordance with a preset dispensing timing pattern which is programmed within the control and timing circuitry (108). RF communication circuitry receives control signals for remotely overriding the preset dispensing timing pattern, reprogramming the control and timing circuitry (108) or terminating the dispensing of the medicament within the body.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: May 3, 2016
    Assignee: Medimetrics Personalized Drug Delivery
    Inventors: Karen I Trovato, Gerhard Spekowius