Osmotic Or Diffusion Pumped Device Or System Patents (Class 604/892.1)
  • Patent number: 10569067
    Abstract: A controlled release nanoparticulate matter delivery system includes a plurality of thermoresponsive modules containing a respective nanoparticulate matter. Each thermoresponsive module is selectively operable in at least one of a heating mode that releases the nanoparticulate matter and a cooling mode that inhibits release of the nanoparticulate matter. A control module is in electrical communication with the plurality of thermoresponsive modules. The control module is configured to determine a temperature of each thermoresponsive module and to select the at least one heating mode and cooling mode based on the temperature. The heating and cooling mode may be selected in response to a desired dosing profile and/or a biometric condition.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: February 25, 2020
    Assignees: RAYTHEON COMPANY, THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Letia M. Blanco, Kyle C. Godfrey, Christopher A. Grace, Christopher B. Alberts, Andrew E. Patin, Panayiotis S. Shiakolas, Pranesh B. Aswath
  • Patent number: 10493103
    Abstract: Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: December 3, 2019
    Assignee: Aclaris Therapeutics, Inc.
    Inventors: Stuart D. Shanler, Christopher Powala, Christopher Phillips, Brian Beger, Charles Rodney Greenaway Evans, Sian Tiong Lim, Marc Barry Brown, Michael A. Botta, Thomas Nagler
  • Patent number: 10265182
    Abstract: A spacer for a knee replacement prosthesis. The spacer may have a lower surface with a locking component adapted to interlock with a tibial tray, an upper surface optionally with a tibial post and a pair of smooth-surfaced and slightly concave condyle support platforms disposed on opposite sides of the tibial post, and a substantially hollow body with an internal reservoir that can be filled with antibiotic material. The reservoir may be accessible from a port on the hollow body that leads into the internal reservoir, and which permits refilling of the reservoir. In some embodiments, the reservoir may be refillable from this port without removal of the spacer from the patient; for example, a percutaneous needle may be inserted into the port. The spacer may dispense antibiotic from this reservoir to the surrounding area in order to treat an infection.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: April 23, 2019
    Assignee: ForCast Orthopedics, Inc.
    Inventor: Jared Ruben Hillel Foran
  • Patent number: 10076500
    Abstract: An elongate dosage form of generally cylindrical shape having two opposing ends, the dosage form being buoyant in gastric fluid, wherein the dosage form is weight biased such that one end is heavier than the other end. The dosage form is adapted to float on gastric fluid with its long axis substantially perpendicular to the surface of the fluid with its heavier end pointing generally downwards and into the fluid.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: September 18, 2018
    Assignee: Jagotec AG
    Inventors: Pascal Grenier, Alain Nhamias, Guy Vergnault
  • Patent number: 9907571
    Abstract: The invention relates to a sampling needle, in particular to a needle suitable for oocyte retrieval from a human or animal subject, said needle comprising a first tubular region in fluid communication with a second tubular region, the first tubular region comprising a leading end for insertion into a subject and the second tubular region comprising a trailing end for fluid communication with a means for receiving a fluid, in which the first tubular region has an outer diameter which is less than the outer diameter of the second tubular region and the first tubular region has an inner diameter which is less than the inner diameter of the second tubular region. The invention also relates to a method of retrieving a sample, in particular an oocyte, from a human or animal subject.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: March 6, 2018
    Assignee: VITROLIFE SWEDEN AB
    Inventor: Urban Hagby
  • Patent number: 9717526
    Abstract: Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 1, 2017
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Scott A. Uhland, Ramkumar Abhishek, Eric Peeters, Timothy J. Curley, Felicia Linn
  • Patent number: 9597227
    Abstract: A portal through the sclera for delivery of an effective amount of therapeutic agent to the back of the eye.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 21, 2017
    Assignee: Abbott Medical Optics Inc.
    Inventors: Daniel J. Urbaniak, John J. Stankus, James Su
  • Patent number: 9522241
    Abstract: A controlled release nanoparticulate matter delivery system includes a plurality of thermoresponsive modules containing a respective nanoparticulate matter. Each thermoresponsive module is selectively operable in at least one of a heating mode that releases the nanoparticulate matter and a cooling mode that inhibits release of the nanoparticulate matter. A control module is in electrical communication with the plurality of thermoresponsive modules. The control module is configured to determine a temperature of each thermoresponsive module and to select the at least one heating mode and cooling mode based on the temperature. The heating and cooling mode may be selected in response to a desired dosing profile and/or a biometric condition.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: December 20, 2016
    Assignees: Raytheon Company, The Board of Regents, The University of Texas System
    Inventors: Letia M. Blanco, Kyle C. Godfrey, Christopher A. Grace, Christopher B. Alberts, Andrew E. Patin, Panayiotis S. Shiakolas, Pranesh B. Aswath
  • Patent number: 9462971
    Abstract: A method may include collecting at least one analyte from within a body, ejecting the collected at least one analyte from the body through at least one dermal layer of the body, and receiving the ejected at least one analyte outside the body. A system may include a means for collecting at least one analyte from within a body, a means for ejecting the collected at least one analyte from the body through at least one dermal layer of the body, and a means for receiving the ejected at least one analyte outside the body.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: October 11, 2016
    Assignee: Gearbox, LLC
    Inventors: Dennis J. Rivet, Roderick A. Hyde
  • Patent number: 9457172
    Abstract: A blood clot removal device for removing blood clots from the vascular system of a patient is implantable in the patient's body. The blood clot removal device comprises a blood flow passageway to be connected to the patient's vascular system to allow circulation of the patient's blood through the blood flow passageway, a filter provided in the blood flow passageway for collecting blood clots occurring in the blood flowing through the blood flow passageway, and a cleaning device for moving blood clots collected by the filter out of the blood flow passageway. By means of such blood clot removal device, the risk of blood clots reaching sensitive areas of the patient's body, such as the brain, is reduced.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: October 4, 2016
    Inventor: Peter Forsell
  • Patent number: 9248216
    Abstract: The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: February 2, 2016
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Maria Palasis, Wendy Naimark, Robert E. Richard
  • Patent number: 9144547
    Abstract: An oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; characterized in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: September 29, 2015
    Assignee: Glaxo Group Limited
    Inventors: Chi Leung Li, Luigi Martini, Vincenzo Re, Helen Anne Willy
  • Patent number: 9028467
    Abstract: Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: May 12, 2015
    Assignee: The Invention Science Fund I, LLC
    Inventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Publication number: 20150100046
    Abstract: The present invention provides devices, systems, and methods for delivery of an active agent into the eye of a subject. An ocular active agent delivery device can include an active agent reservoir disposed in an annular housing, the annular housing being configured to fit inside of a lens capsule and at least partially encircling a line of sight of an intraocular lens within the lens capsule. The device can further allow diffusion of an active agent from the active agent reservoir.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 9, 2015
    Inventors: Balamurali K. Ambati, Bruce K. Gale
  • Patent number: 8998886
    Abstract: Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: April 7, 2015
    Assignee: The Invention Science Fund I, LLC
    Inventors: Leroy E. Hood, Muriel Y. Ishikawa, Edward K. Y. Jung, Robert Langer, Clarence T. Tegreene, Lowell L. Wood, Jr., Victoria Y. H. Wood
  • Patent number: 8992962
    Abstract: An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: March 31, 2015
    Assignee: Intarcia Therapeutics Inc.
    Inventors: Scott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
  • Patent number: 8971958
    Abstract: A portable personal medical device, e.g., a wearable insulin pump, is provided with a web server and is controllable over a network by a browser equipped client, thereby enabling comprehensive and comfortable control, operation and/or configuration of the device.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: March 3, 2015
    Assignee: Roche Diagnostics International AG
    Inventors: Marcel Frikart, Markus Jungen
  • Patent number: 8932618
    Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: January 13, 2015
    Assignee: Confluent Surgical, Inc.
    Inventors: Phillip D. Blaskovich, Rachit Ohri, Steven L. Bennett
  • Patent number: 8926595
    Abstract: The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another aspect, the present invention provides beneficial agent formulations for use in the osmotic delivery devices. The formulations include formulations wherein beneficial agents are soluble in the vehicle, suspension formulations comprising particle formulations of one or more beneficial agent, and combinations thereof. Further, methods for treatment of a variety of diseases or conditions using two or more beneficial agents are disclosed, wherein the methods are preferably practiced using the osmotic delivery devices and/or formulations of the invention.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: January 6, 2015
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Thomas R. Alessi, Karling Alice Leung, Ryan D. Mercer, Cristina G. Negulescu, Catherine M. Rohloff, Bing Yang
  • Patent number: 8924023
    Abstract: A method for evaluating dosing from an implanted infusion system that includes receiving input regarding the identity of a therapeutic agent into an external device. The method further includes displaying on the external device a predetermined set of symptoms associated with the therapeutic agent; receiving input into the external device regarding with which of the symptoms the patient presents; and determining whether the therapeutic agent is being delivered, or has been delivered, at an appropriate dose based on the input identity of the therapeutic agent and the input symptoms.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: December 30, 2014
    Assignee: Medtronic, Inc.
    Inventor: Emem Akpan
  • Patent number: 8920376
    Abstract: The filling status of a drug reservoir in a drug pump devices may be determined with mechanical and/or magnetic position sensor associated with a reservoir boundary.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: December 30, 2014
    Assignee: MiniPumps, LLC
    Inventors: Sean Caffey, Po-Ying Li, Yu-Chong Tai, Jeffrey Brennan
  • Patent number: 8810394
    Abstract: A number of parameters related to the operation of a fluid delivery device are determined based on a pressure within the device sensed using a pressure sensor. In one example, the volume of therapeutic fluid added to or removed from a reservoir of a fluid delivery device is determined based on a sensed pressure of the reservoir. In another example, the volume of therapeutic fluid added to or removed from the reservoir is determined based on a sensed pressure of a refill port assembly of the device. In another example, an initial temperature of the reservoir as a therapeutic fluid is removed from the reservoir is estimated based on a sensed pressure within the device. In another example, a temperature of a therapeutic fluid added to the reservoir is estimated based on a sensed pressure within the device.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: August 19, 2014
    Assignee: Medtronic, Inc.
    Inventor: Scott L. Kalpin
  • Patent number: 8801700
    Abstract: An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: August 12, 2014
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Thomas R. Alessi, Michael A. DesJardin, Stan Lam, Scott D. Lautenbach, Pauline C. Zamora
  • Patent number: 8795260
    Abstract: An expiration time of a therapeutic fluid delivered by an implantable fluid delivery device is employed to calculate a fill volume and determine a refill interval for the fluid. The expiration time of the therapeutic fluid may be based on or dictated by a stability time set by the manufacturer of the therapeutic fluid, a clinician treating a patient to whom the fluid is to be delivered, the manufacturer of the device delivering the fluid, or combinations thereof.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 5, 2014
    Assignee: Medtronic, Inc.
    Inventor: Touby A. Drew
  • Patent number: 8784308
    Abstract: A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention. In accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: July 22, 2014
    Assignee: Proteus Digital Health, Inc.
    Inventors: Hooman Hafezi, Robert Duck, Timothy Robertson, Benedict Costello
  • Patent number: 8715269
    Abstract: Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: May 6, 2014
    Inventors: Andy Wolff, Ben Z Beiski, Simon Herrlich, Axel Schumacher, Sven Spieth, Stephan Messner, Rachid Nouna
  • Patent number: 8684996
    Abstract: Methods for setting a basal rate profile for an insulin pump, wherein the basal rate profile defines a basal rate delivery for a selected time interval and has a pre-defined number of profile segments each of which define the basal rate delivery for a subset of the selected time interval, include providing a curve representing the basal rate as a continuous function of time as an input for an input unit and generating the basal rate profile from the curve by a calculation unit by assigning curve values at selected time instances to the pre-defined number of profile segments.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: April 1, 2014
    Assignee: Roche Diagnostics International AG
    Inventors: Ulrich Haueter, Daniel Von Buren, Catalin Cris, Stephan Marcin
  • Patent number: 8647329
    Abstract: An osmotic pump includes a plurality of agent reservoirs; first and second solute chambers; a semi-permeable membrane separating the first and second solute chambers from one another; a flexible membrane separating a first one of the agent reservoirs from the first solute chamber; and a plurality of valves. Each of the valves is moveable between an open position in which a corresponding one of the agent reservoirs is open to an outlet of the pump and a closed position in which the corresponding one of the agent reservoirs is sealed with respect to the pump outlet.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: February 11, 2014
    Assignee: New York University
    Inventor: Erwin R. John
  • Patent number: 8642060
    Abstract: A device includes a first reservoir configured to include a degradation agent, a second reservoir configured to include an osteogenerative agent, and a controller configured to selectively initiate access to the first reservoir or the second reservoir.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: February 4, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Hai H. Trieu
  • Patent number: 8642059
    Abstract: A device includes a sensor configured to determine a condition associated with a nucleus pulposus, a reservoir configured to include a first agent capable of affecting the condition associated with the nucleus pulposus, a control element configured to provide access to the reservoir, and a controller in communication with the sensor and the control element. The controller is configured to manipulate the control element to provide access to the reservoir in response to the condition determined by the sensor.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: February 4, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Hai H. Trieu
  • Patent number: 8617143
    Abstract: Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided. In various embodiments, a device for controlled release of an active ingredient is provided, including a release aperture operably associated with a deflectable member, a base with a porous membrane substrate layer, and at least one chamber juxtaposed between the release aperture and the porous membrane layer. The chamber may contain a matrix including one or more active ingredients and an agent that expands when contacted with an aqueous solution. The device is suitable for implantation in a biological system and can be used for delayed and/or time release of specific drug dosages for various indications.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: December 31, 2013
    Assignee: The Regents of the University of California
    Inventors: Mark Bachman, Baruch Kuppermann, Asheesh Divetia, Guann Pyng Li
  • Patent number: 8608642
    Abstract: An environmentally sensitive hydrogel material swells or collapses in response to a parameter such as pH level associated with consumption of food by a patient. This swelling or collapsing is harnessed to treat morbid obesity or some other condition of the patient. The swelling or collapsing of the hydrogel may be used to tighten a gastric band or gastric valve when the patient starts eating; then loosen the band or valve when the patient is between meals. The swelling or collapsing of the hydrogel may also be used to increase the size of a space occupying device in the patient's stomach when the patient starts eating; then decrease the size of the space occupying device when the patient is between meals. The swelling or collapsing of the hydrogel may also be used to selectively restrict the absorption of nutrients within a patient's gastrointestinal tract, such as in the duodenum.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: December 17, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Janna M. Burrell, Randal T. Byrum, Robert Louis Koch, Jr., Larry D. Pool, Christopher W. Widenhouse
  • Publication number: 20130296833
    Abstract: The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
    Type: Application
    Filed: July 11, 2013
    Publication date: November 7, 2013
    Inventors: PHILLIP D. BLASKOVICH, RACHIT OHRI, STEVEN L. BENNETT
  • Patent number: 8529538
    Abstract: Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: September 10, 2013
    Assignee: MiniPumps, LLC
    Inventors: Changlin Pang, Fukang Jiang, Jason Shih, Sean Caffey, Mark Humayun, Yu-Chong Tai
  • Patent number: 8491571
    Abstract: An orifice device for delivering one or more drugs includes an inner member having a proximal end and a distal end; and a winding helically wound around the inner member. The winding includes a plurality of distinct wires helically wound in parallel around the inner member. The winding and the inner member define at least three separate channels for carrying one or more drugs therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding for the plurality of distinct wires. In some embodiments, at least two of the plurality of distinct wires have a different dimension. An outer member is used over the winding. Also, at least two of the at least three separate channels have a different fluid flow rate. And, in some embodiments, at least two of the at least three separate channels carry a different drug.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: July 23, 2013
    Assignee: Cordis Corporation
    Inventor: Scott M. Russell
  • Patent number: 8495515
    Abstract: Disclosed is a method of configuring a medical device through utilization of a computing device that includes a user interface, a processor and memory. The method includes the steps of determining whether a configuration file contains a focal modified parameter, displaying the focal modified parameter, prompting a manual re-entry of the displayed focal modified parameter, receiving through the user interface the manual re-entry of the displayed focal modified parameter, and utilizing the processor to automatically determine whether the manual re-entry of the displayed focal modified parameter matches the displayed focal modified parameter.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: July 23, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Jason M. Bush, David B. Markisohn, Kristin Westerfield, Laura Wilkerson
  • Patent number: 8470353
    Abstract: An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
    Type: Grant
    Filed: January 12, 2013
    Date of Patent: June 25, 2013
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Scott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
  • Publication number: 20130138089
    Abstract: An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
    Type: Application
    Filed: January 12, 2013
    Publication date: May 30, 2013
    Applicant: INTARCIA THERAPEUTICS, INC.
    Inventors: Scott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
  • Publication number: 20130090633
    Abstract: An osmotic patch pump may include a dry agent on a die-cut piece of film that may exert an osmotic pressure when dissolved by a fluid. A chamber may contain the dry agent and have a chamber wall made of a semi-permeable membrane that allows fluid to enter the chamber through the membrane, but does not allow dissolved agent to escape from the chamber through the membrane. A sponge may have a surface in contact with an outer surface of the semi-permeable membrane and may be configured to soak up fluid when placed in contact with the sponge. Flow volume and rate may be controlled by user-operated micro valves. The chamber and fluid communication channels may be embossed on a substrate as part of a simple and low cost manufacturing process.
    Type: Application
    Filed: October 8, 2012
    Publication date: April 11, 2013
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: University of Southern California
  • Patent number: 8382700
    Abstract: A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: February 26, 2013
    Assignee: Sensile Pat AG
    Inventors: Sigfrid Straessler, Uwe Beyer
  • Publication number: 20130041353
    Abstract: The present disclosure relates, according to some embodiments, to compositions, methods, devices, and systems for delivering a composition (e.g., a fluid composition) to a subject. For example, the present disclosure relates to non-gassing, direct current (DC), electro-osmotic pumps in some embodiments. A pump may comprise an anode (e.g., a porous silver/silver oxide anode), a cathode (e.g., a porous silver/silver oxide cathode), and a membrane (e.g., a porous ceramic membrane) positioned at least partially between the anode and the cathode in some embodiments. A pump system may comprise an electro-osmotic pump, a reservoir comprising a pump fluid chamber in fluid communication with the electro-osmotic pump and a delivery fluid chamber in fluid communication with the electro-osmotic pump; a controller assembly in electrical communication with the anode and the cathode; and a cannula and/or a needle in fluid communication with the delivery fluid chamber.
    Type: Application
    Filed: March 9, 2011
    Publication date: February 14, 2013
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Woonsup Shin, Adam Heller, Rajaram Nagarale
  • Patent number: 8367095
    Abstract: An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: February 5, 2013
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Scott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
  • Publication number: 20130018360
    Abstract: This invention relates to a method of delivering ophthalmic drugs, specifically prostaglandins and prostamides. This method may also be applied to other types of intraocular pressure (IOP)-lowering drugs (e.g. carbonic anhydrase inhibitors, beta blockers, alpha-adrenergic agonists, and parasympathomimetics) as well as other types of ophthalmic drugs for other indications (e.g. dry eye, inflammation, and infection).
    Type: Application
    Filed: June 22, 2012
    Publication date: January 17, 2013
    Inventors: Marissa Dockendorf, G√ľnter Solms, Bailin Laing, Bret A. Coldren, Gary Yewey, Gerald Yewey
  • Patent number: 8348909
    Abstract: An implantable delivery device including a housing, a port assembly, and a plurality of grooves. The housing includes an outer wall defining an exterior face. The port assembly includes a septum and a port opening that is exteriorly open relative to the housing face. The plurality of grooves are formed in the exterior face proximate the port opening, and are sized to receive a needle tip to guide the needle tip toward the port opening. In one embodiment, the port assembly is fluidly connected to a reservoir, such that the port assembly constitutes a reservoir refill port.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: January 8, 2013
    Assignee: Medtronic, Inc.
    Inventors: James M. Haase, Wende L. Dewing, William K. Wenger, Beth Bullemer
  • Patent number: 8348930
    Abstract: A fluid delivery device can be used to deliver fluid within a living body. The fluid delivery device includes an electrochemical pump, a reservoir, a displaceable member, and a diffuse membrane. The electrochemical pump transports water and includes an electrochemical pump product chamber to retain water transported by the electrochemical pump. The reservoir contains a fluid to be delivered. The displaceable member is positioned between the electrochemical pump product chamber and the reservoir. The displaceable member is responsive to the electrochemical pump transporting water into the electrochemical pump product chamber. The diffuse membrane generates increased pressure within the electrochemical pump product chamber.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: January 8, 2013
    Assignee: Microlin, LLC
    Inventors: John Howard Gordon, Ashok V. Joshi
  • Patent number: 8343140
    Abstract: The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery devices useful for substantially concurrent administration of two or more beneficial agents. In another aspect, the present invention provides beneficial agent formulations for use in the osmotic delivery devices. The formulations include formulations wherein beneficial agents are soluble in the vehicle, suspension formulations comprising particle formulations of one or more beneficial agent, and combinations thereof. Further, methods for treatment of a variety of diseases or conditions using two or more beneficial agents are disclosed, wherein the methods are preferably practiced using the osmotic delivery devices and/or formulations of the invention.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: January 1, 2013
    Assignee: Intarcia Therapeutics, Inc.
    Inventors: Thomas R. Alessi, Karling Alice Leung, Ryan D. Mercer, Cristina G. Negulescu, Catherine M. Rohloff, Bing Yang
  • Patent number: 8346399
    Abstract: An apparatus for delivering a bolus of a medical agent to a patient. The apparatus comprises a pump mechanism, a data input device, and a processor in data communication with the keypad and arranged to control the pump mechanism. The processor is programmed to receive data specifying a bolus amount through the data port, receive data regarding duration through the data port, receive a percentage through the data port, the percentage defining a portion of the bolus amount to deliver immediately upon executing a deliver command and a remainder of the bolus amount to deliver over the duration upon executing a deliver command, and execute the deliver command thereby controlling the pump mechanism to deliver the bolus. Also a method of temporarily adjusting the delivery rate of an infusion pump. The infusion pump is programmed to deliver a basal rate.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 1, 2013
    Assignee: Tandem Diabetes Care, Inc.
    Inventor: Michael L. Blomquist
  • Patent number: 8337548
    Abstract: An implant comprising a body (1), at least one active pharmaceutical substance (4) and an element (5, 15, 35, 45, 55) deflectable in relation to the body, serving to release the at least one active pharmaceutical substance (4) during or after an external excitation of the deflection. Also disclosed is a system of such an implant and an excitation device (30, 70).
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: December 25, 2012
    Assignee: Biotronik vi Patent AG
    Inventors: Bjoern Klocke, Matthias Fringes, Eugen Hofmann
  • Publication number: 20120303001
    Abstract: An osmotic pump includes a plurality of agent reservoirs; first and second solute chambers; a semi-permeable membrane separating the first and second solute chambers from one another; a flexible membrane separating a first one of the agent reservoirs from the first solute chamber; and a plurality of valves. Each of the valves is moveable between an open position in which a corresponding one of the agent reservoirs is open to an outlet of the pump and a closed position in which the corresponding one of the agent reservoirs is sealed with respect to the pump outlet.
    Type: Application
    Filed: July 23, 2012
    Publication date: November 29, 2012
    Applicant: New York University
    Inventor: Erwin R. JOHN
  • Publication number: 20120289944
    Abstract: Highly concentrated drug particle formulations are described, wherein the drug comprises between about 25 wt % and 80 wt % of the particle formulation. The particle formulations of the present invention comprise, for example, macromolecules, such as proteins and/or small molecules (such as steroid hormones). The particle formulation typically further includes one or more additional component, for example, one or more stabilizer (e.g., carbohydrates, antioxidants, amino acids, and buffers). Such concentrated particle formulations can be combined with a suspension vehicle to form suspension formulations. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a highly concentrated drug particle formulation. Devices for delivering the suspension formulations and methods of use are also described.
    Type: Application
    Filed: July 7, 2012
    Publication date: November 15, 2012
    Applicant: INTARCIA THERAPEUTICS, INC.
    Inventors: Thomas R. Alessi, Ryan D. Mercer, Catherine M. Rohloff, Bing Yang