Abstract: Surgical retrieval devices for capturing tissues and fluids in endoscopic and laproscopic operations include a semi-rigid, resiliently collapsible and expandable basket comprising a structural combination of resilient, semi-rigid snare wire and frame wire members that are formed with a yieldable bend configuration that together flare into a basket form when extended out of a catheter. The basket is enhanced by surrounds of net, mesh, or impervious material for retaining smaller bits of tissue or fluids, or with a web of interspersed flexible threads for enhanced tissue retaining capability.

Abstract: A medical device includes a treatment portion, a long cylindrical insertion portion, an operation portion and transmission portion. The insertion portion includes a regulation member provided while being projected from an inner wall surface of the insertion portion for regulating a length by which the treatment portion protrudes from the distal end of the insertion portion. The transmission portion includes an operation wire inserted in the insertion portion and has a distal end fixed to the treatment portion and an contacting member fixed to the operation wire and disposed at a position opposite to the treatment portion with respect to the regulation member. A rotating bearing member contacting the regulation member and the contacting member respectively and can rotate relative to at least any one of the regulation member and the contacting member around an axis of the operation wire is provided between the regulation member and the contacting member.

Abstract: A medical device may include an elongate member, and a plurality of grasping members extending from the elongate member. Each of the grasping members may include a proximal end, and a distal end. Each of the grasping members may include at least one first section formed of a first material and a second material, and a second section located at the distal end of the grasping member. The second section may be formed without the first material and being less stiff than the at least one first section.

Abstract: A medical device that may include a plurality of first branch members, and a plurality of second branch members is disclosed. The medical device may also include a first movable member, and a second movable member. The plurality of first and second branch members and the first and second movable members may form a basket movable between a collapsed configuration and an expanded configuration.

Abstract: A retrieval apparatus for entrapping and retaining an object located in a body for its extraction therefrom is described. The retrieval apparatus includes a snare and a snare control assembly. The snare has a proximal section and a distal section, and comprises a plurality of filaments extending from a proximal end of the proximal section towards the distal section, and then returning to the proximal end to form a plurality of loops. In the deployed state, the loops are interlaced to each other within the proximal section and are free and not interleaved within the distal section. Segments of the filaments of the distal section are bent with respect to segments of the filaments of the proximal section such that the retrieval snare in the contracted, state forms a hollow cavity extending from die distal section towards the proximal section.

Abstract: A combined multi-lumen central access catheter and an embolic filter, further comprising an imaging modality to facilitate intravascular imaging of the filter.

Abstract: A combined multi-lumen central access catheter and an embolic filter, further comprising an imaging modality to facilitate intravascular imaging of the filter.

Abstract: Braid-balls suitable for aneurysm occlusion and/or parent vessel occlusion/sacrifice (e.g., in treating neurovascular defects) are disclosed. Especially for aneurysm treatment, but also for either one of the aforementioned treatments, the form of the ball is very important. In particular, the density of the device is paramount in applications where braid itself is intended to moderate or stop blood flow—allowing thrombosis within a volume formed by the ball.

Abstract: A general-purpose stone extractor is provided for removing gallstones, calculi or foreign bodies from the biliary tree, urinary tract, blood vessels and the like. The stone extractor is configured to enable catcher wires to be extracted and retracted from an outer sheath near to a stone by operating a push handle member, an elastic spring being installed between a proximal end of the outer sheath and the push handle member.

Abstract: A method for removing a kidney stone from a ureter may involve: advancing a distal end of an elongate, flexible kidney stone removal device into the ureter to a location near the kidney stone; advancing an expandable stone retention member out of an inner shaft of the device; visualizing at least part of the stone retention member with a camera disposed coaxially within the stone retention member; trapping the kidney stone in the stone retention member; surrounding at least a portion of the stone retention member and the trapped kidney stone with a wall protection member on the distal end of the kidney stone removal device; and removing the kidney stone removal device from the ureter while the stone retention member and the kidney stone are at least partially surrounded by the wall protection member.

Abstract: Devices and methods for removal of calculus (including for example, kidney stones) are disclosed. In an embodiment, a device for removal of kidney stones includes a substantially sealable pouch that can be inserted into the kidney for capturing a kidney stone. The pouch is also designed to permit fragmentation of the kidney stone inside the pouch, while preventing kidney stone fragments from escaping from the pouch. As a result, the likelihood of dispersing stone fragments during fragmentation of a large stone is greatly lessened.

Abstract: A steerable medical device is used to controllably introduce a guidewire or other medical instrument into a body of a patient and direct placement of the guidewire or other medical instrument in the body of the patient. The steerable medical device can include an elongated member, a steering mechanism, and an attachment member. The elongated member extends along a longitudinal axis and comprises a deflectable distal portion that is deflectable off of the longitudinal axis. The steering mechanism is adapted to control longitudinal and rotational movement of the elongated member and to control off-axis deflection of its deflectable portion. The attachment member is removably couplable to another medical device. The attachment member is moveably coupled to the steering mechanism and the elongated member.

Abstract: A device may include a handle, and a sheath coupled to the handle. The sheath may include a lumen. The device may also include an instrument assembly coupled to the handle, and extending through the lumen of the sheath. The instrument assembly may include a basket configured to move relative to the sheath, and between contracted and expanded states. The instrument assembly may also include a forceps configured to reciprocate along a central longitudinal axis of the basket and through an interior of the basket, and move between contracted and expanded states.

Abstract: An apparatus is provided for removing material within a body lumen that includes a catheter including a proximal end, a distal end for introduction into a body lumen, and an aspiration lumen extending therebetween; a guide member extending from the distal end and terminating in a distal tip, the guide member comprising a track adjacent a track lumen extending from the distal tip into the aspiration lumen; and an obstruction clearing device deployable from the guide member and retractable along the track. In addition or alternatively, the apparatus includes a cutting head reciprocable within the aspiration lumen adjacent the distal end for macerating material being aspirated into the aspiration lumen.

Abstract: The foreign object extractor has an elongated hollow tube with a central lumen through its entire length providing fluid connection between an engaging end and a vacuum source. The engaging end has a nominally round transverse cross-section and is shaped to engage a foreign object to be removed from the human body. The engaging end flares so as to expose the internal surface of the elongated hollow tube for engagement with the foreign object. An adhesive is disposed on the exposed internal flared surface of the distal end. Pneumatic suction is applied through the lumen of the extractor and the suction serves to bring the foreign object into contact with the adhesive coated surface of the extractor to form a bond between the extractor and the object to be extracted.

Abstract: Methods and apparatuses of treating meibomian glands are disclosed. The method comprises applying regulated heat to an eyelid to reach a temperature adequate to melt at least one obstruction within at least one meibomian gland. The method also comprises maintaining the regulated heat for a time period adequate to place the at least obstruction in the melted state. The method further comprises positioning a pressure application device into contact with the patient's eyelid and applying a pressure with the pressure application device over a substantial portion of the eyelid to express the at least one obstruction from the meibomian gland. An apparatus suitable to treat meibomian glands comprises a heater, a controller, and a pressure applicator configured to be placed into contact with the eyelid and apply a pressure over a substantial portion of the eyelid to express the at least one obstruction from the meibomian gland.

Abstract: The present invention improves significantly the success rate of lithotripsy and reduces the risk of tissue damage, by injecting a temporary plug in front, and optionally behind a concretion (for extracorporeal lithotripsy) or behind a concretion (for intracorporeal lithotripsy). One aspect of the present invention relates to injecting an inverse thermosensitive polymer solution into a lumen, thereby preventing the migration of a concretion, or its fragments, upon extracorporeal or intracorporeal lithotripsy.

Abstract: A rotary catheter drive unit containing a motor and a seal-set, an output shaft of the motor being power transmittingly connected to a flexible shaft that is rotatably disposed through the seal-set, the seal-set comprising a bearing and an adjacent seal defining a first and a second concentric bores, respectively, the first bore being slightly larger than a diameter of the shaft so that it rotatably and accurately supports the shaft, the second bore being slightly smaller than the diameter so that it seals around the shaft, the bearing aligning the shaft, so that it is concentric with the second bore, by deflecting the shaft to compensate for eccentricity and misalignment of the second bore relative to the output shaft of the motor.

Abstract: An aspiration thrombectomy catheter system includes an aspirator and an aspiration catheter for insertion in a blood vessel. The catheter has a shaft with a proximal end for connection with the aspirator and a tapering distal end with a tip for insertion in the vessel. A plurality of aspiration ports are arranged in sets along the tapering distal end, for aspirating thrombus from the vessel. At least one aspiration lumens within the shaft conducts thrombus from the vessel, through the aspiration ports, to the aspirator. Variably sized or shaped ports provide differing aspiration vectors for enhanced thrombus removal. The aspiration thrombectomy catheter additionally provides for uniform drug dispersion at a thrombotic area, alone or in combination with aspiration of the thrombus. In the event of an adverse reaction, drug dosage may be easily reduced by aspirating dispersed drugs back into the catheter.

Abstract: A device and related method of use is provided for the capture and removal of various unwanted objects present within the body's anatomical lumens. In an embodiment of the present disclosure, the device includes an external elongate member; an internal elongate member disposed within the external elongate member; and a retrieval assembly connected to the internal elongate member and retractable within and extendable from a lumen of the external elongate member. The retrieval assembly includes an end configured to be selectively open or substantially closed.

Abstract: A method for removing a kidney stone from a ureter may involve: advancing a distal end of an elongate, flexible kidney stone removal device into the ureter to a location near the kidney stone; advancing an expandable stone retention member out of an inner shaft of the device; visualizing at least part of the stone retention member with a camera disposed coaxially within the stone retention member; trapping the kidney stone in the stone retention member; surrounding at least a portion of the stone retention member and the trapped kidney stone with a wall protection member on the distal end of the kidney stone removal device; and removing the kidney stone removal device from the ureter while the stone retention member and the kidney stone are at least partially surrounded by the wall protection member.

Abstract: A medical device that may include a plurality of branch members forming a basket movable between a collapsed configuration and an expanded configuration is disclosed. Each branch member may include a proximal coil, and a distal coil. Each branch member may also include an uncoiled portion disposed between the proximal coil and the distal coil, and a movable portion.

Abstract: A method and apparatus for treating a clot in the blood vessel of a patient, and particularly the treatment of a pulmonary embolism is disclosed. The treatment includes restoring flow through the clot followed by clot removal, either partially or substantially completely. The clot treatment device is expandable into the blood vessel and may contain radial extensions that assist in restoring flow as well as in removing clot material.

Abstract: A surgical retrieval apparatus includes a handle including an elongated sleeve extending therefrom that, together cooperate to define a lumen therethrough. A shaft having an end effector assembly disposed at a distal end thereof and a plunger disposed at a proximal end thereof is selectively translatable between a first position and a second position, wherein the end effector assembly extends from the sleeve. An articulation mechanism is configured to articulate the end effector assembly relative to the shaft. A specimen retrieval bag is coupled to the end effector assembly and is deployable to an extended position upon movement of the end effector assembly to the second position.

Abstract: Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.

Abstract: Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.

Abstract: Thrombus aspiration may be performed using manual negative intermittent suction (e.g., provided by a syringe) or using an automated negative suction device (e.g., provided by a vacuum pump). The suction device may be connected through suction tubing to a hub of a catheter. The automated negative suction device may include an external control panel for the operator configured to allow the operator to choose from any of a plurality of suction patterns during an aspiration procedure.

Abstract: A method of performing a medical procedure is disclosed. The method includes: positioning an energy delivery device configured to deliver energy adjacent uric acid (UA) crystals having a resonance frequency; applying energy to tissue through the energy delivery device at a predetermined frequency thereby resonating the UA crystals; debulking at least a portion of the UA crystals; and removing at least a portion of the debulked UA crystals.

Abstract: Aspiration catheters may include parameters for facilitating aspiration of thrombi within blood vessels. For example, parameters of the catheters (e.g., inner lumen diameter, slot pitch) may be varied along a length of the catheter to cause changes in suction pressure, thereby resulting in improved thrombus aspiration. The aspiration catheters may include a balloon to temporarily occlude flow during an aspiration procedure.

Abstract: A medical device includes a sheath defining a lumen, a first elongate member, and a second elongate member. The first and second elongate members are movably disposed within the lumen. The medical device further includes a basket comprising a plurality of legs and a mesh portion. A proximal end of each leg of the plurality of legs is connected to the first elongate member, and a proximal end of the mesh portion is connected to the second elongate member.

Abstract: An apparatus is provided for removing material within a body lumen that includes a catheter including a proximal end, a distal end for introduction into a body lumen, and an aspiration lumen extending therebetween; a guide member extending from the distal end and terminating in a distal tip, the guide member comprising a track adjacent a track lumen extending from the distal tip into the aspiration lumen; and an obstruction clearing device deployable from the guide member and retractable along the track. In addition or alternatively, the apparatus includes a cutting head reciprocable within the aspiration lumen adjacent the distal end for macerating material being aspirated into the aspiration lumen.

Abstract: Methods for restoring blood flow in occluded blood vessels using an apparatus having a self expandable distal segment that is pre-formed to assume a superimposed structure in an unconstrained condition but can be made to take on a volume-reduced form making it possible to introduce it with a microcatheter and a push wire arranged at the proximal end, with the distal segment in its superimposed structure assuming the form of a longitudinally open tube and having a mesh structure of interconnected strings or filaments or struts. In a preferred embodiment, the distal segment has a tapering structure at its proximal end where the strings or filaments or struts converge at a connection point.

Abstract: The devices and methods described herein relate to improved structures for removing obstructions from body lumens. Such devices have applicability in through-out the body, including clearing of blockages within the vasculature, by addressing the frictional resistance on the obstruction prior to attempting to translate and/or mobilize the obstruction within the body lumen.

Abstract: A medical device for collecting objects from a body lumen comprises a catheter, a basket having a closed first end and an open second end, and an actuator connected to the closed first end of the basket, the catheter and basket moveable relative to one another between a first configuration and a second configuration to draw objects from a body lumen into the basket. In the first configuration the closed first end of the basket is inside the catheter and the open second end is everted over at least a part of the closed first end. The apparatus may be actuated to pull the closed first end of the basket further into the catheter and invert the second end of the basket, the second end scraping the sides of the lumen as it inverts, surrounding an object in the lumen, and drawing the object into the basket.

Abstract: A medical device, and related method, for manipulating material, such as calculi, within a patient's body includes a handle, a sheath, a retrieval basket, and a retainer coupled to the distal end of the retrieval basket. The retrieval basket includes a plurality of legs, each of which includes an intermediate portion located at the distal end of the retrieval basket. The retainer secures at least the intermediate portion of one of the plurality of legs to the intermediate portion of another of the plurality of legs.

Abstract: A ureteral decompression device comprises a guide member and an anchoring structure. The guide member may be introduced through the urethra and bladder into the ureter so that the anchor structure passes a lodged kidney stone. Once past the stone, the anchor structure can be compacted to anchor the guide member in place. The anchor structure will permit leakage and the guide member will provide a leakage path directly past the stone, thus decompressing the kidney.

Abstract: An endoscopic stone-extraction device is provided comprising a support filament comprising an end portion having a plurality of stacked loops, a sheath comprising a lumen, wherein the support filament is disposed in the lumen such that the sheath is slideable with respect to the support filament, and a handle comprising an actuator. Movement of the actuator in a first direction retracts the sheath and causes the plurality of stacked loops to expand outside the lumen in an arc-like shape. Movement of the actuator in a second direction advances the sheath and causes the plurality of stacked loops to at least partially collapse inside the lumen. Other embodiments are provides, and any of these embodiments can be used alone or in combination.

Abstract: A method of removing thrombus accumulation from a space between a body valve and a wall of a body vessel is described herein. The method can include an occlusion catheter with a first occlusion member positioned on the second side of the vessel. An aspiration catheter is introduced through the vessel and the valve. The aspiration catheter can have a nozzle with a bent configuration to position the end opening proximate to the thrombus accumulation.

Abstract: A radial deployment surgical tool having an inner shaft, an outer shaft and a function head. The radial deployment surgical tool is adapted for performing surgical procedures within narrow regions within a patient.

Abstract: A guide wire includes elements in a telescoping arrangement which impart stiffness to the guide wire for maneuverability in the tortious cardiac vessels. This arrangement also creates engagements between an inner shaft and the tip, that when released, result in a tip which can move outward with forces sufficient to penetrate a lesion in the coronary vessels.

Abstract: An atherectomy device and method has cannula systems having lumens adapted for insertion of a blood filter and an atherectomy catheter useful for performing atherectomy directly on a patient's cardiovascular tissue. Other embodiments include a lumen for arterial perfusion useful in providing oxygenated blood to the aorta during cardiopulmonary bypass. The distal end of the atherectomy catheter includes an assembly that has a pincer, a loop with or without a mesh, laser, hydraulics, or other suitable mechanism adapted for removing atheroma from a cardiac or vascular tissue. Methods of using the systems for vascular atherectomy are also disclosed herein.

Abstract: The present invention provides devices and methods for removal of obstructive matter from the patients that are located inside or outside of the patient's endovascular system using rotational energy.

Abstract: A medical retrieval device used to remove objects such as urinary and biliary calculi from the body comprising a handle assembly with an independent rotational means, a sheath, and an object entrapping assembly. In preferred embodiments, the handle assembly comprises a longitudinally stationary base portion with a handle base and a rotating means and a thumb slide actuation means located between the distal and proximal ends of the handle base portion. Actuation of the thumb slide relative to the handle base causes the object entrapping assembly to be actuated between the open and closed positions. Rotation of the rotating means relative to the handle base causes precise rotation of the object entrapping assembly. The thumb slide actuation means and rotating means are separate and independent of each other, preventing inadvertent adjustment of the degree of actuation during rotation and preventing inadvertent adjustment of rotational position during actuation.

Abstract: A method for removing a kidney stone from a ureter may involve: advancing a distal end of an elongate, flexible kidney stone removal device into the ureter to a location near the kidney stone; advancing an expandable stone retention member out of an inner shaft of the device; visualizing at least part of the stone retention member with a camera disposed coaxially within the stone retention member; trapping the kidney stone in the stone retention member; surrounding at least a portion of the stone retention member and the trapped kidney stone with a wall protection member on the distal end of the kidney stone removal device; and removing the kidney stone removal device from the ureter while the stone retention member and the kidney stone are at least partially surrounded by the wall protection member.

Abstract: A system for removing a kidney stone from a ureter may include: an elongate, flexible, outer shaft having a distal end configured to be advanced into the ureter and a proximal end; an elongate, flexible, inner shaft extending through at least part of the outer shaft; an expandable stone retention member extending through at least part of the inner shaft and moveable along the longitudinal axis relative to the inner shaft; an elongate, flexible camera positioned coaxially within the retention member shaft, such that a distal end of the camera is located at or near a distal end of the inner shaft; and a handle coupled with the proximal end of the outer shaft, a proximal end of the inner shaft, and a proximal end of the retention member shaft.

Abstract: A device for use within an occluded biological vessel and a method of using same to remove occlusion material from a vessel are provided. The device includes an elongated body configured for delivering projections arranged around a distal portion thereof into the biological vessel. Each of the projections includes a leaf-like structure connected to a stem portion having a higher axial rigidity than the leaf-like structure.

Abstract: A kit for surgically removing stones comprising: a double barreled sheath including a first barrel and a second barrel joined side-by-side; a first connector which is engaged at the proximal end of the first barrel; a second connector which is engaged at the proximal end of the second barrel; a first rigid tube interconnecting the first barrel with the first connector with the first connector being releasably engaged to the first rigid tube and the first rigid tube, first barrel and first connector being co-axial; a second rigid tube interconnecting the second barrel with the second connector with the second connector being releasably engaged to the second rigid tube and the second rigid tube, second barrel and second connector being co-axial; and a wire basket retriever adapted for insertion into one of the barrels and being releasably engaged with a connector or an actuation device.

Abstract: A multi-wire instrument has a distal functional section, in which a plurality of individual wires form a wire basket, wherein they are combined at a distal end and connected to one another by being joined directly to one another or to a distal terminating body while forming a respective predetermined breaking connection. A shaft section extends between the distal functional section and a proximal end region of the multi-wire instrument. The individual wires extend in one piece from their distal end to the proximal end region of the multi-wire instrument and the shaft section is formed by the individual wires, which are combined there and held together.

Abstract: An aspiration device can be used to aspirate an obstruction from a blood vessel. The aspiration device is configured to allow controlled one-handed aspiration yet maintain a syringe plunger feel of vacuum. The aspiration device also allows one-handed injection to empty the device when needed. Furthermore, mechanisms enable one-handed locking of a plunger position of the device to maintain vacuum when the user releases the device.

Abstract: A retrievable device for treatment of a stenotic lesion in a body vessel is disclosed. The device comprises a reticulation portion including a plurality of struts connected together in a singly staggered configuration distally along a longitudinal axis. The plurality of struts of the reticulation portion is configured to fold along the longitudinal axis defining a collapsed state of the device for retrieval. The device further includes an expandable body distally extending from the reticulation portion along an outer diameter for treatment of the stenotic lesion. The expandable body is configured to expand in the open state and collapsed in the collapsed state of the reticulation portion for retrieval. The device further comprises a retrieval stem extending proximally from the reticulation portion for retrieval of the device in the collapsed state.