Abstract: A dermatome having a blade assembly, where the blade assembly includes a blade and a blade mount. The blade may include a blade edge, a reference edge and at least one hole or receiver positioned between the blade edge and the reference edge. The blade mount may include a base, a blade locator extending from the base and at least one reference fence abutting the reference edge of the blade. The blade locator may include a protrusion for inserting into the hole or receiver of the blade. The blade and blade mount of the blade assembly may self align and provide for a simple and permanent connection.

Abstract: A dermatome having a main body, a blade assembly and a blade guard, where the blade assembly has a blade edge and the blade guard has a base and a fence extending from the base toward the blade assembly so as to face the blade edge. The blade guard may include at least one blade assembly locator to facilitate the alignment of the blade guard with the blade assembly. A blade guard assembled on the blade assembly may operate so as to prevent unintended contact between the blade edge and objects.

Abstract: A kit of components for extracting and storing a skin tissue sample includes an extraction cartridge with a plurality of blades, an actuator cartridge, and a cap with an aqueous preservative. The actuator cartridge is removeably attached to the extraction cartridge and causes the plurality of blades of the extraction cartridge to extract a skin tissue sample from the person. After the skin tissue sample is extracted, the cap is attached to the extraction cartridge to store and suspend the skin tissue sample in an aqueous preservative preloaded in a container in the cap. A liquid-tight seal prevents bodily fluids from contaminating the actuator cartridge and this enables the actuator cartridge to be removed from the extraction cartridge and to be reused. The extraction cartridge and the attached cap, which store the skin tissue sample, are sent to medical laboratory so that the skin tissue sample can be analyzed.

Abstract: A dermatome having a handle and an attachment including a valve, where the valve may include a first bobbin at least partially defining a first flow path and a second flow path, a second bobbin at least partially defining a first flow path, an inlet port at least partially defined by the second bobbin and an outlet port at least partially defined by the first bobbin. The ports of the valve may open in response to an application of a mechanical act to the attachment and the ports may close in response to the absence or removal of the mechanical act.

Abstract: Devices and methods for obtaining a plurality of skin tissue particles for use in skin grafting.

Abstract: Embodiments of the present invention provide Dermal Micro-organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure.

Abstract: The invention generally relates to devices for generating and transferring micrografts and methods of use thereof. In certain embodiments, devices of the invention include a housing having an open configuration and a closed configuration, a micrograft generating station, and a micrograft transferring station.

Abstract: The present invention generally relates to devices for harvesting a skin graft(s). The present invention provides a blister raising device integrated with a member for cutting the blister.

Abstract: A portable and disposable device is provided for processing harvested dermal tissue. The device includes a housing presenting a handle having a gripping surface and a cutting head attached to the handle. A cutting assembly is supported by the cutting head and includes a plurality of spaced cutting blades that are rotatable with respect to the housing. A receptacle is disposed downstream of the cutting assembly and receives the sliced tissue from the cutting blades. The device is thus operable to slice harvested tissue into strips, and further into fine particles, that can be used for transplantation onto a wound site.

Abstract: A dermatome assembly is operable to harvest a skin graft and includes an ultrasonic dermatome and a power supply. The ultrasonic dermatome includes a body and an ultrasonic blade assembly mounted in the body. The blade assembly includes a frequency generator and a cutting horn powered by the frequency generator. The cutting horn is spaced apart from the body so that the body is restricted from damping vibrational movement of the cutting horn. The dermatome assembly is operable to precisely control the thickness of the cut skin graft and also restrict the cutting horn from overheating.

Abstract: Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. The exemplary apparatus can be provided that includes a plurality of such tubes for simultaneous harvesting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, or less than about 0.3 mm, which can promote healing of the donor site and/or viability of the harvested tissue. The micrografts can be approximately cylindrical or strip-shaped, and can be placed in a biocompatible matrix to form a graft or directly into tissue at the recipient site. Such exemplary micrografts can be obtained from skin or other types of tissue, e.g., various internal organs.

Abstract: The present invention generally relates to methods for applying a skin graft. Methods of the invention involve harvesting an epidermal skin graft, and applying the epidermal skin graft to a recipient site such that the basal layer of the skin graft makes direct contact with the recipient site.

Abstract: The present invention generally relates to methods for preparing a skin graft. In certain embodiments, methods of the invention involve harvesting a plurality of skin grafts from a subject, applying the grafts to a first substrate, stretching the first substrate, and transferring the grafts from the first substrate to at least a second substrate for application to a patient recipient site.

Abstract: The present invention generally relates to devices for harvesting a skin graft(s). The present invention provides a blister raising device integrated with a member for cutting the blister.

Abstract: The present invention generally relates to methods for preparing a skin graft without culturing or use of biologics

Abstract: An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response.

Abstract: A dermatome has a main body with a first profile and at least one blade assembly with a blade, a size, an orientation corresponding to the main body, and a second profile. The second profile has characteristics corresponding to the first profile to properly orient and locate the at least one blade for proper mounting of the blade to the main body. The profiles are shaped to provide clearance for the second profile to reciprocate relative to the first profile.

Abstract: Methods and apparatus are provided for affecting an appearance of skin by harvesting small portions of tissue from a donor (first) site and applying them at a recipient (second) site. A plurality of micrografts can be formed from a piece of graft tissue and attached to a dressing material. The dressing material can then be expanded to increase a separation distance between the micrografts, and the dressing material having spaced-apart micrografts attached thereto can be applied to a prepared recipient site. An apparatus can be provided that expands the dressing material using a pressurized fluid. A further method can include providing a suspension of small portions of graft tissue in a solution. The solution can be injected into blisters formed at a recipient (second) site and the tissue portions allowed to attach and proliferate. A method and apparatus can also be provided for forming corresponding blisters at a donor site and at a recipient site.

Abstract: A new minimally invasive surgical approach is proposed that contemplates a method and apparatus for tightening lax skin without visible scarring via a device in various surgical procedures such as plastic surgery procedures. In some embodiments, the device is a single use disposable instrument. This approach circumvents surgically related scarring and the clinical variability of electromagnetic heating of the skin and performs small multiple pixilated resections of skin as a minimally invasive alternative to large Plastic surgical resections of skin. This approach can also be employed in areas of the body that are currently off limits to plastic surgery due to the visibility of the surgical scar. In addition, the approach can perform a skin grafting operation by harvesting the transected incisions of skin from a tissue site of a donor onto a skin defect site of a recipient with reduced scarring of the patient's donor site.

Abstract: A dermatome has a main body with a first profile and at least one blade assembly with a blade, a size, an orientation corresponding to the main body, and a second profile. The second profile has characteristics corresponding to the first profile to properly orient and locate the at least one blade for proper mounting of the blade to the main body. The profiles are shaped to provide clearance for the second profile to reciprocate relative to the first profile.

Abstract: A device for processing harvested dermal tissue includes a body having a cutting head portion and a handle portion extending from the cutting head portion. The cutting head portion defines a chamber. A cutting assembly is disposed in the chamber and includes a plurality of blades and a flexible spacer member disposed on the axle such that the blades rotate as the axle rotates. Each of the plurality of blades is separated from an adjacent blade by a spacer disposed on the axle. A grill assembly is coupled to the body and includes a grill and a grill cap. The grill has a plurality of spaced apart slots sized and configured to receive the blades and maintain the blades in a position with respect to the body. The grill cap is sized and configured to couple the grill to the cutting head portion of the body.

Abstract: Methods and devices to process harvested skin tissue and to immediately reintroduce the ground tissue into the patient to repair a tissue defect are disclosed. A hand-held portable tissue grinder comprising a housing and a grinding element are disclosed. The tissue grinder is used for grinding skin and subcutaneous tissue and includes a sterile polymer housing having a first opening adapted to receive the skin and subcutaneous tissue. The tissue grinder also includes a sterile grinding element disposed substantially within the housing. The grinding element includes a plurality of cutting surfaces adapted to operably engage with the housing to provide ground tissue and further includes a handle mechanism coupled to the grinding element to move the grinding element with respect to the housing to grind the skin and subcutaneous tissue, wherein the ground tissue can be removed from the housing.

Abstract: A dermal tissue transplantation system combining a tissue particle harvester, a tissue particle collector, and a chambered dressing. The system provides a harvester capable of harvesting tissue from a donor site on the order of about 100 microns. The integrated tissue particle collector provides a means for collecting the harvested tissue for in situ cultivation in a chambered dressing at the wound site.

Abstract: A cell colonies dissecting and transplanting apparatus comprises: a base, a platform, a feeding mechanism having at least three axis feeding means, a movable holder, a cutting means, a transplanting means, and a CCD image capturing means. The platform having the CCD image capturing means therebottom is disposed onto the base, and on the platform is defined with the holder for receiving a plurality of loading trays, so as to the original cell colonies and a plurality of media boards of subculture can be placed on the loading trays of holder, the holder can displace from a first axis feeding means and a second axis feeding means of feeding mechanism to moveably align with a first axis and a second axis.

Abstract: A portable and disposable device is provided for processing harvested dermal tissue. The device includes a housing presenting a handle having a gripping surface and a cutting head attached to the handle. A cutting assembly is supported by the cutting head and includes a plurality of spaced cutting blades that are rotatable with respect to the housing. A receptacle is disposed downstream of the cutting assembly and receives the sliced tissue from the cutting blades. The device is thus operable to slice harvested tissue into strips, and further into fine particles, that can be used for transplantation onto a wound site.

Abstract: A tissue processing system includes a series of blades arranged in parallel to form a tissue processor. The blades may be adjusted to create a spaced between each blade in the range of 250-1000 microns. A slicer is included to remove a donor tissue to be processed by the processor. The processor is rotatable 90 degrees so as to create uniform micrografts of tissue for transplanting to a recipient site. An extractor is included to remove tissue particles from the processor after they have been cut into an appropriate size. A cutting block may be provided to ensure uniform thickness of cuts of the donor tissue.

Abstract: An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response.

Abstract: A dermal tissue transplantation system combining a tissue particle harvester, a tissue particle collector, and a chambered dressing. The system provides a harvester capable of harvesting tissue from a donor site on the order of about 100 microns. The integrated tissue particle collector provides a means for collecting the harvested tissue for in situ cultivation in a chambered dressing at the wound site.

Abstract: A portable and disposable device is provided for processing harvested dermal tissue. The device includes a housing presenting a handle having a gripping surface and a cutting head attached to the handle. A cutting assembly is supported by the cutting head and includes a plurality of spaced cutting blades that are rotatable with respect to the housing. A receptacle is disposed downstream of the cutting assembly and receives the sliced tissue from the cutting blades. The device is thus operable to slice harvested tissue into strips, and further into fine particles, that can be used for transplantation onto a wound site.

Abstract: A dermatome has a blade that generally defines a plane and a body generally defining a longitudinal axis. The body also that has at least one flat outer surface for engaging the tissue and an end portion that is configured to hold the blade so that the plane of the blade is generally parallel to the longitudinal axis and non-parallel to the flat outer surface at a predetermined angle.

Abstract: A dermatome has a main body with a first profile and at least one blade assembly with a blade, a size, an orientation corresponding to the main body, and a second profile. The second profile has characteristics corresponding to the first profile to properly orient and locate the at least one blade for proper mounting of the blade to the main body. The profiles are shaped to provide clearance for the second profile to reciprocate relative to the first profile.

Abstract: A dermatome assembly is operable to harvest a skin graft and includes an ultrasonic dermatome and a power supply. The ultrasonic dermatome includes a body and an ultrasonic blade assembly mounted in the body. The blade assembly includes a frequency generator and a cutting horn powered by the frequency generator. The cutting horn is spaced apart from the body so that the body is restricted from damping vibrational movement of the cutting horn. The dermatome assembly is operable to precisely control the thickness of the cut skin graft and also restrict the cutting horn from overheating.

Abstract: A suture anchor having a conical surface and a bore in which an end of an insertion tool is inserted. The insertion end of the insertion tool is made of material having elastic properties. The bore and base of the suture anchor are angled with respect to the central axis of the suture anchor and preferably are parallel to each other. During insertion, the suture anchor is reoriented to fit into the hole, thereby bending the elastic end of the insertion tool. When the suture anchor is within cancellous bone tissue, the elastic properties of the insertion tool deploy the suture anchor to an orientation in which the suture anchor cannot fit through the bone hole, thereby firmly anchoring the suture anchor in the human bone.

Abstract: A method of securing a soft tissue implant to damaged tissue of a patient is provided. The method includes preparing a layer of extracellular matrices (ECM) for surgery. The method further includes stretching the layer on a frame and securing the layer to the frame. The method includes placing a top surface of the layer adjacent the damaged tissue, drilling multiple holes generally simultaneously through the layer and tissue, and simultaneously inserting a fastener into each drilled hole.

Abstract: An accessory device attachable to a hand piece producing a beam for removal of hair from the skin of a patient prior to skin treatment on a body part, such device including a strip of material disposed between the hand piece and the patient's skin to interfer with the beam emitted from the hand piece to heat the surface of the skin under the material for burning only the hair and not the skin of the patient, such burnt hair adhering to the material. A method of removing hair from the skin of a body part of a patient prior to skin treatment on such body part is also disclosed.

Abstract: A multiple bladed surgical knife for removing donor strips of hair-laden scalp tissue from a donor for hair graft transplantation to a donor. The knife includes a plurality of blades which are spaced apart by a plurality of spacers. The blades may advantageously shift longitudinally with respect to each other at a surgeon's discretion such that donor strips of consistent depth are obtained. In addition, the number of hair follicles which are destroyed during the removal process is minimized. In one embodiment of the present invention, the blade penetration depth is controlled via selectively sizing and shifting the plurality of spacers. In one particular embodiment, the blades and spacers may be shifted with the assistance of a pin, and in another embodiment, the knife includes a plurality of markings indicating a particular blade angle.

Abstract: The invention relates to a device for reusing a strip of residue skin after drilling out grafts for the formation of additional grafts. The device comprises a support beam for supporting the strip of skin, equipped with elevated and recessed portions which are adapted to the shape of the strip of skin and in such a manner that two successive elevated or recessed portions define an area in the strip of skin which has to be cut up to form a graft. The invention also comprises a method wherein the strip of skin is placed on the support bar, a graft is excised by means of a cutting tool and it is transferred from the support bar to a magazine. The support bar, the magazine and the cutting tool are then moved relative to one another, thus making a new area of the strip of skin accessible to the cutting tool and a new receptacle in the magazine is provided in alignment with the said area.

Abstract: The invention relates to a skin support (19) for use in connection with the excision of grafts (2a) from a piece of skin (2), where the piece of skin (2) is attached to a frame (1) and the graft (2a) is excised from the piece of skin (2) by means of a hollow drill (9). The skin support (19) is arranged to abut against the piece of skin (2) and is movable relative to the frame (1). The skin support (19) further comprises devices for controlling the skin support's (19) movement automatically, and in such a manner that at least a section (20) of the skin support (19) is moved towards the frame (1) when the hollow drill (9) approaches the frame, the section (20) remains stationary relative to the frame (1) while the hollow drill (9) penetrates the piece of shin (2) and it is moved away from the frame (1) when the hollow drill (9) is removed therefrom.

Abstract: A device for removing unwanted hair, including a hair-plucking assembly, and a vibration assembly, a driving assembly, and a housing. The hair-plucking assembly includes two groups of disc assemblies that remove hair as they rotate. As the hair-plucking assembly removes hair, the vibration assembly vibrates to massage the area of hair removal to minimize discomfort associated with the hair removal.

Abstract: The present invention provides a stent-graft assembly. The assembly comprises at least one stent framework and a graft member. The graft member is positioned adjacent an inner surface of the stent framework and everted over an outer surface of the stent framework to enclose at least a portion of the stent framework. The assembly may further comprise a therapeutic agent that is enclosed by the graft member. Elution openings may be formed in the graft member to preferentially elute a therapeutic agent into the wall rather than the lumen of a vessel into which the stent-graft assembly is placed.

Abstract: A dermal tissue transplantation system combining a tissue particle harvester, a tissue particle collector, and a chambered dressing. The system provides a harvester capable of harvesting tissue from a donor site on the order of about 100 microns. The integrated tissue particle collector provides a means for collecting the harvested tissue for in situ cultivation in a chambered dressing at the wound site.

Abstract: A tool is provided for use in acquiring a treatment portal on the skin surface of a patient undergoing radiation therapy or the like. The portal acquisition tool includes a template portion having a cut-out pattern for marking the treatment portal on the skin and a handle portion which both facilitates use of the template and includes ruled markings for taking measurements. Additionally, the handle portion is provided with transverse lines for assisting the therapist in altering the source-to-skin distance during the administration of electron energy and an opaque backing which serves as a screen for reflecting the optical distance indicator projected by the linear accelerator.

Abstract: Mechanically actuated dermatome comprising a cutting blade, a hollow handle substantially perpendicular to the plane of the cutting blade and a motor housed in the hollow handle with its shaft substantially perpendicular to the plane of the cutting blade. The cutting blade is enclosed in a housing which has a lowermost surface that rides on the skin during treatment, the lower surface being essentially parallel to the plane of the cutting part of the blade and the handle is substantially perpendicular to it and directed upwards when the dermatome rests on the lowermost surface of the blade housing. The lowermost surface that rides on the skin during treatment is smooth, without any protrusion that may interfere with its movement in any direction with respect to the skin.

Abstract: An attachment for an appliance for the epilation of the human skin, the appliance being provided with a housing to accommodate a motor for driving at least one clamping device rotary about a first axle for purposes of epilation, the attachment being provided with at least one element for reducing the perception of pain during epilation, which element makes contact with the skin prior to the epilation.

Abstract: An apparatus for increasing the rate of expansion of tissue area and volume, either in vivo or in vitro, which comprises a tissue expansion device suitable for expansion of tissue and a controller connected to the device, wherein the controller causes the device to subject the tissue to stretching forces that alternatively increase and decrease to provide a series of stretch and relax phases during a period of tissue expansion without intervention of an operator.

Abstract: A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated human vaginal xenografts in order to screen a wide range of candidate antimicrobials administered topically or systemically.

Abstract: A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated human vaginal xenografts in order to screen a wide range of candidate antimicrobials administered topically or systemically.

Abstract: Hand-held appliance for preparation of an excised skin graft, that is placed upon a plane surface, by tangential excision of tissue below the epidermis to produce a trimmed skin graft of desired remaining tissue layers and thickness with a blade that is held between two holding rods, that can be placed on a plane surface and that is held in a height-adjustable axis parallel to the surface. The end regions of the rods are shaped so that the distance between the axis and the contact surface of the edge of the end regions to the surface changes at least by sections, while the minimal distance and the maximal distance define the lowest and the highest cutting plane, respectively, so that the distance of the cutting plane is defined by the operating angle between the plane of the rods and the surface.

Abstract: A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated human vaginal xenografts in order to screen a wide range of candidate antimicrobials administered topically or systemically.

Abstract: Hand-held appliance for preparation of an excised skin graft, that is placed upon a plane surface, by tangential excision of tissue below the epidermis to produce a trimmed skin graft of desired remaining tissue layers and thickness with a blade that is held between two holding rods, that can be placed on a plane surface and that is held in a height-adjustable axis parallel to the surface. The end regions of the rods are shaped so that the distance between the axis and the contact surface of the edge of the end regions to the surface changes at least by sections, while the minimal distance and the maximal distance define the lowest and the highest cutting plane, respectively, so that the distance of the cutting plane is defined by the operating angle between the plane of the rods and the surface.