Abstract: A device and method for repairing a mitral valve leaflet 2, 3. The device 10 includes a body 16 having an annular wall 18 and at least one aperture 22 through the annular wall 18. A deployment assembly 24 mounted on the body includes at least one grasping wire 28 arranged for sliding movement in the aperture 22. Movement of the deployment assembly 24 to a deployed position relative to the body causes a free end of the grasping wire 28 to project out from the annular wall 18 through the aperture 22, and movement of the deployment assembly to a retracted position relative to the body causes the free end of the grasping wire 28 to not project out from the annular wall 18. In the deployed position, the grasping wire 28 may grasp and gather tissue of the leaflet 2,3.

Abstract: An aneurysm closure clip along with a system and method for use by a physician in delivering the closure clip into the vasculature of a patient is disclosed. The closure clip delivery system comprises a delivery tube in the form of a catheter, a guide wire, and a detachable closure clip. The closure clip includes a proximal side and a distal side. The distal side comprises at least two winged elements that interact with the wall of the body vessel to hold the clip in place after delivery. The proximal side includes a seal element and a guide bar. The guide bar is in communication with the guide wire during delivery. The seal element forms a barrier between the aneurysm and the rest of the body vessel, thereby, reducing any pressure exerted on the aneurysm. The seal element and optionally the winged elements include a material layer comprised of bioremodelable material, such as an extracellular matrix material (ECM).

Abstract: A surgical stapler having a hollow shaft 10 and a tube 92 slidable axially within the shaft between a forward position wherein one end 96 of the tube projects beyond a free end of the shaft to enter a puncture site in a blood vessel and a rearward position wherein the end of the locator tube is retracted within the shaft. A surgical staple 40 straddles the tube 92 and is slidable thereon forwardly towards an anvil 24 against which the staple may be deformed to staple together the opposite edges of the puncture site. A cam mechanism drives the staple forwardly along the tube 92 into deforming engagement with the anvil and at the same time retracts the tube into the shaft in time to allow the legs of the staple to close onto the puncture site.

Abstract: A proctological instrument is disclosed comprising an instrument handle to which at its proximal end a bending-resistant tubular shaft is mounted at the distal end of which a cap is fixed or formed to which a tissue clip adapted to be withdrawn from the cap by means of a releasing or withdrawing device is attached in a preferably spring-elastic manner. In accordance with the invention, the tubular shaft is offset at its distal end portion in an area directly ahead of the cap and/or the cap itself is offset at a predetermined fixed angle so that the withdrawing direction for the clip defined by the cap is aligned at the angle with respect to the tubular shaft axis.

Abstract: Embodiments of a clamping system are disclosed. In some embodiments, a system used with a motor assembly and a clamping device is presented, the system adjusting torque limits in the motor assembly according to conditions, for example operating temperature of the motor assembly and aging of the clamping device and the motor assembly. The clamping device can be, for example, a stapler or a vessel sealer.

Abstract: A biodegradable device for providing scaffolding for a trocar defect to promote healing. The device consists of an upper and lower scaffold, offset by a connector. The device is arranged so the distance between the lower surface of the upper scaffolding and upper surface of the lower scaffolding holds the fascia around the trocar defect while promoting tissue growth. The surfaces of the scaffolding in contact with the trocar defect are textured to maximize adherence to tissue.

Abstract: A transcatheter method of gathering tissue of a heart valve leaflet may include inserting an elongated catheter assembly to a position adjacent the heart valve leaflet, the catheter assembly including a capture tool moveable between a retracted position and an extended position, a tissue support, and a clamping member moveable between an open position and a closed position. The capture tool may be partially retracted to gather tissue of the heart valve leaflet between the tissue support and the clamping member. The clamping member may then be moved from the open position toward the closed position so as to clamp a substantial portion of the gathered tissue of the heart valve leaflet between the tissue support and the clamping member. Subsequently, a clip may be applied from the catheter assembly to the clamped tissue so as to hold the clamped tissue substantially in a gathered configuration.

Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.

Abstract: Medical systems, devices and methods are provided for engaging tissue, e.g. for clipping tissue, closing a perforation or performing hemostasis. Generally, the medical system including a housing, first and second jaws rotatable relative to the housing, a driver, and an elongate drive wire. The elongate drive wire may be disconnected from the driver, first and second jaws, and the housing, which are left in vivo engaged with the tissue.

Abstract: The present embodiments provide systems and methods for deploying at least one clip during a medical procedure. In one embodiment, the system comprises a clip having first and second arms. A locking pin is coupled to the clip and disposed for incremental movement relative to the clip. Further, a tether is coupled to the locking pin, wherein a first tether segment is secured to a distal region of the second arm, and a second tether segment is secured to a distal region of the first arm. In use, proximal retraction of the locking pin causes a proximal retraction of the first and second tether segments to move the clip between open and closed states. Incremental retraction of the locking pin incrementally advances the clip between the open and closed states.

Abstract: Medical devices and systems for easily and reliably closing a perforation in tissue. One embodiment of a medical device for use with a scope includes a tubular member having a distal end, an exterior surface and an interior space. A carrier element extends along the exterior surface and around the distal end of the tubular member. An elastic band is positioned on the carrier element around the exterior surface of the tubular member. A staple is positioned within the interior space of a tubular member and includes first and second prongs which are spaced apart and translatable relative to one another. The carrier element is structured to deliver the elastic band beyond the distal end of the tubular member where upon the elastic band contracts and engages the staple to translate the first and second prongs towards each other.

Abstract: Described here are devices, systems, and methods for providing remote traction to tissue. Generally, the systems may include a grasper and a delivery device configured to releasably couple to the grasper. The grasper may have a first jaw and a second jaw and a main body having a barrel portion. The barrel portion may have a lumen extending therethrough, and a portion of the delivery device may be advanced through the lumen to rotate one or both of the jaws. The delivery devices may include a handle, a shaft, and a distal engagement portion. The delivery devices may further include an actuation rod which may be advanced through a barrel portion of a grasper to actuate the grasper. In some instances, the delivery device may further include a locking sheath, wherein the locking sheath is configured to temporarily couple to a grasper.

Abstract: An apparatus for delivering and deploying a closure element to an opening formed in a body lumen, including a delivery assembly positionable through the tissue and into the opening. The delivery assembly includes a distal locator portion and a carrier assembly oriented proximal to the distal locator portion. The distal locator portion is configured to selectably engage the body lumen adjacent to the opening, and the carrier assembly is configured to carry and support the closure element in a substantially tubular configuration. The carrier assembly is further configured to urge the closure element toward an expanded cross-sectional dimension for deployment thereof, such that the closure element is oriented to engage the tissue when deployed and, when released, to return to the natural, substantially planar configuration and the natural cross-section dimension wherein the engaged tissue is drawn substantially closed.

Abstract: An improved system for mammography analysis and methods of using the same. In one aspect, a clip comprises a first portion and at least one additional second portion connected to the first portion, the first and second portions adapted for elastic deformation for engaging tissue. In anther aspect, an improved actuator for performing a breast biopsy is used to deploy a clip. In yet another aspect of the invention, there is contemplated a system for marking an evacuated breast cyst.

Abstract: A vascular closure device comprising a retrievable sheath-delivered contractible, clip device with structural radial or terminal members with terminal and non-terminal hooks that engage the vessel wall. Unlike other vascular closure clips, this device is delivered on the outside rather than the inside of sheath. Closure of the tissue opening can be effected by the feet of the clip engaging the puncture, aperture, or wound edges and memory characteristics of the device cause a contraction of the members, bringing the members into apposition and the wound edges together, permitting immediate vascular closure and healing of the blood vessel. The device can be delivered and recovered by an intravascular sheath.

Abstract: Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes a fastener and an advanceable, deformable clip having a delivery configuration in which opposing sides do not contact one another, and a deployed configuration, in which the fastener causes opposing sides of the deformable clip to close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The clip is then deformed with the fastener to draw opposing sides of the puncture together, and the sheath is withdrawn to seal the wound. The clip and fastener preferably are bioabsorbable.

Abstract: A method for suturing a perforation comprises the steps of: observing an area around the perforation from an inside of a hollow organ by an observation device inserted from a natural opening of a living body; observing the area around the perforation from a body cavity side of the hollow organ by an observation device inserted from the natural opening of the living body; thrusting a needle of a suture unit inserted from the natural opening of the living body into a tissue around the perforation of the hollow organ to make a suture thread puncture the tissue via the needle; and closing the perforation by tightening up the suture thread puncturing the tissue.

Abstract: An apparatus enables concurrent restoration of a gastroesophageal valve and tightening of the lower esophageal sphincter. The apparatus comprises a longitudinal member having a distal end arranged to be received within a stomach, a tissue shaper at the distal end of the longitudinal member that forms a gastroesophageal valve from stomach tissue, and a tissue gatherer that gathers fundus tissue at or aboral to the gastroesophageal junction to reduce an esophageal opening into the stomach and tighten the lower esophageal sphincter. A fastener deployer then deploys at least one fastener pair to maintain both the restored gastroesophageal valve and the tightened lower esophageal sphincter.

Abstract: Various embodiments are directed to an apparatus and method of driving an end effector coupled to an ultrasonic drive system of a surgical instrument. The method comprises generating at least one electrical signal. The at least one electrical signal is monitored against a first set of logic conditions.

Abstract: An apparatus for application of surgical clips is provided and includes a lockout system selectively engageble with a pusher bar to prevent the pusher bar from returning to a home position and to prevent a trigger from completing a full stroke when a plurality of clips are substantially exhausted. The apparatus may include a trip mechanism including a trip lever biased into contact with the pusher bar, wherein distal movement of the drive bar moves the trip mechanism until the trip lever engages a lip of the pusher bar and in turn distally moves the pusher bar. The apparatus may include a wedge plate including a distal end placeable between spaced-apart jaw members, wherein the wedge plate is moved proximally to withdraw the distal end thereof from between the jaw members when a drive channel is moved in a distal direction.

Abstract: Provided is a surgical instrument including an external tube (2) and two elongated members (4) positioned in the tube (2), each of which includes a distal end (10a) for capturing one of the two tissue zones (M1, M2) to be attached. The instrument (1) may further include a catching member (22, 25) for each tissue (M1, M2) to be attached; a rod (15, 16) linked to each catching member (22, 25) enabling tension to move axially, the rod (15, 16) being separable from said catching member (22, 25) when a tension is exerted on it beyond a certain threshold; and a member (17a) forming a stop for locking axially each catching member (22, 25) during the tensioning.

Abstract: A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.

Abstract: Suture clip appliers, suture clips and methods of their use for securing sutures during an endoscopic or laparoscopic procedure are provided, wherein the method includes the steps of providing a suture clip applier having a working tip configured to retain and fire a suture clip; providing a suture clip having a biased closed configuration; loading the suture clip into the working tip of the clip applier; translating the suture clip distally relative to the working tip to a first position wherein the suture clip is splayed open; inserting a suture into the opened suture clip; and translating the suture clip distally relative to the working tip such that the suture clip is ejected from the working tip and biased to the closed configuration to close on and to retain the suture.

Abstract: A tissue plication device and method of using the same is described. The tissue plication device includes a helical fastener having a distal portion with a first pitch and a proximal portion with a second pitch that is smaller than the first pitch. The method includes introducing the distal tip of the helical fastener into the tissue and advancing the helical fastener to plicate the tissue. Another tissue plication device includes a helical fastener having a first configuration with a first pitch and a second configuration with a second pitch. The helical fastener in the first configuration is advanced into a tissue and then converted to the second configuration by applying a stimulus.

Abstract: An instrument for fastening tissue within a body includes an elongated tube having a proximal end for extending outside of the body and a distal end for positioning proximate the tissue; and a distal member configured to fold the tissue together. The distal member includes a first member having a proximal end coupled to the distal end of the tube; and a second member pivotably coupled to the distal end of the first member. The first and second members are configured to install at least one fastener. A grasper is coupled to at least one of the first member and the second member. The second member is pivotable between an open position for receiving tissue and a closed position for folding tissue therebetween. The grasper is configured to project outward from at least one of the first member and the second member when in the open position.

Abstract: A tissue clipping apparatus, comprises a flexible, elongate member, a proximal end of which remains external to the body accessible to a user while a distal end of the flexible member is inserted into the body to a location adjacent to target tissue to be clipped and a control wire extending through the flexible member in combination with a capsule releasably coupled to a distal end of the flexible member and a clip a proximal portion of which is received within the capsule. A joint releasably coupling the clip to the control wire, includes a yoke extending around a proximal end of the clip and a frangible link which fails when subject to a predetermined force to separate the clip from the control wire.

Abstract: An apparatus for the repair of a cardiovascular valve has leaflets comprising a grasper capable of grabbing and co-apting the leaflets of the valve. In a preferred embodiment, the grasper has jaws that grasp and immobilize the leaflets, and then a fastener is inserted to co-apt the leaflets. The apparatus is particularly useful for repairing mitral valves to cure mitral regurgitation.

Abstract: This invention provides hermetically-sealed handle assembly with a rotating trigger for use with disposable components, such as surgical clip appliers. The rotating trigger reduces the gripping force necessary to fully control the internal actuator mechanism to operate a disposable surgical clip applier to fully ligate a vessel or other tissue. The hermetic seal on the handle assembly prevents any patient fluids and other bioburden from entering the internal structures. This reduces the possibility of cross-contamination and the costs of sterilization.

Abstract: A delivery system and method for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The delivery system includes a hollow catheter, an anchor coupled to the catheter, and an implant secured within the anchor. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. Surfaces of the arms and legs are adapted to clamp the anchor to a wall. The system further includes a pusher wire adapted to cause the anchor to acquire a stowed configuration in which the legs axially extend from the base portion, permitting the anchor to be retrieved after its deployment.

Abstract: Medical device used to cause hemostasis of blood vessels using a clip arrangement delivered to a target region through an endoscope. Method for using the device to cause hemostasis of a blood vessel through an endoscope. Medical device including a reversibly closeable clip, a locking arrangement, a control wire, a sheath, and a handle with an actuating trigger. Through the endoscope, hemostatic clipping device that is fully reversible and lockable. Hemostatic clip that reversibly targets and clips bleeding ulcers.

Abstract: A surgical instrument including a frame, an elongate portion, a drive beam and an end effector is disclosed. The elongate portion extends distally from the frame. The drive beam is disposed at least partially within the elongate portion and is translatable with respect to the elongate portion. The end effector is disposed adjacent a distal end of the elongate portion and includes first and second jaw members. The first jaw member is movable with respect to the second jaw member. The first jaw member includes a proximal camming surface and a distal camming surface thereon. A surgical fastener cartridge is disposed in the first jaw member. an actuation portion of the drive beam has an upper member arranged to contact the distal camming surface causing approximation of the jaw members. Proximal translation of the drive beam causes the actuation portion of the drive beam to contact the proximal camming surface effecting opening of the jaw members.

Abstract: An anchor for a medical implant, methods of manufacturing the anchor, and procedures for placing a medical implant, such as for diagnosing, monitoring and/or treating cardiovascular diseases. The anchor has a base portion with first and second longitudinal ends and a cage therebetween. The anchor further has flexible arms, flexible legs, features for securing the medical implant within the cage of the base portion, and a coupler portion connected to and spaced apart from the second longitudinal end of the base portion. The anchor is adapted to have a deployed configuration in which the arms and legs radially project away from the base portion, the arms axially project toward the second longitudinal end of the base portion, and the legs axially project toward the first longitudinal end of the base portion. Convex surfaces of the arms and legs are adapted to clamp the anchor to a wall.

Abstract: A ligation apparatus that ligatures living tissue using a clip and provides an optimal ligation apparatus for ligaturing living tissue in a body cavity. The ligation apparatus includes a clip with a clip claw member that is advanced and retreated relative to a pressing member to open and close, a sheath configured to accommodate the clip such that the clip claw member is not exposed to the outside, an advance and retreat restricting mechanism which restricts advance and retreat of the pressing member relative to the sheath at a distal end portion of the sheath and allows advance and retreat of the clip claw member relative to the pressing member according to advance and retreat of the operation wire relative to the sheath to allow the clip ligaturing living tissue, and a releasing mechanism which releases at least a portion of the clip when the clip ligatures the living tissue.

Abstract: A treatment method on tissues in a body cavity includes: a first step of forming a hole for communicating first body tissue with second body tissue while both are in close contact with each other; and a second step of endoscopically inserting a treatment device into the second body tissue through the hole.

Abstract: A system and method for delivering a surgical clip to a surgical site within a patient's body to compress body tissue is disclosed. In one embodiment for the system of the present invention, the system includes an endoscopic device that has an endoscope cap disposed on a distal end of the endoscopic device. A surgical clip is removably disposed on an outside surface of the endoscope cap. A deployment device is associated with the surgical clip for deploying the surgical clip from the endoscope cap to the body tissue that is to be compressed. The surgical clip can be a deformable clip that is deployed in a non deformed configuration, and is then deformed so as to apply compression on selected tissue. The surgical clip can be a multi-legged clip, having a plurality of legs that can be locked in a closed position to apply compression to body tissue.

Abstract: In a surgical method, an incision is formed in a layer of organic tissue defining a wall having an inner side and an outer side. The incision has a pair of opposing lips or edges. The lips or edges are retracted towards the inner side of the tissue wall and approximated to one another. Thereafter, one or more closure elements are applied to the inwardly pulled lips or edges.

Abstract: Systems and methods introduce and deploy prosthesis into a blood vessel or hollow body organ by intra-vascular access. The prosthesis is secured in place by fasteners which are implanted by an applier that is also deployed by intra-vascular access. The applier is configured to permit controlled, selective release of the fastener in a step that is independent of the step of implantation.

Abstract: A medical device includes a distal portion sized and shaped for insertion into a body lumen and including a capsule having a lumen extending therethrough and a plurality of windows in a proximal end thereof; a bushing including a channel extending therethrough, a distal end thereof including a plurality of arms extending distally therefrom such that a corresponding one of the arms is releasably engagable with a corresponding one of the windows of the capsule, the arms being biased toward a centerline of the bushing in a release configuration; and a bushing support receivable within the channel of the bushing to apply a radially outward pressure to the arms such that the arms lockingly engage the windows of the capsule, the arms formed of a material selected such that movement of the bushing support out of the channel reverts the arms to the release configuration.

Abstract: Methods and devices for treating obesity are provided, and more particularly, methods and devices for performing gastric bypasses are disclosed. In one exemplary embodiment a gastric bypass procedure is provided that includes forming a gastro-entero anastomosis between a stomach and an intestine and forming an entero-entero anastomosis between a portion of the intestine distal to the gastro-entero anastomosis and a portion of the intestine proximal to the gastro-entero anastomosis. A surrogate path is formed between the esophagus and the gastro-entero anastomosis to at least partially direct fluid from the esophagus to the intestine by way of the gastro-entero anastomosis, thereby bypassing the stomach. Still further, methods for repairing an abdominal aortic aneurysm and leaking heart valve are also disclosed.

Abstract: A medical treatment tool is provided having: a force transmission member having a distal end and a proximal end; an end effector which is provided on the distal end of the force transmission member in a non-rotatable manner with respect to the force transmission member; a control wire which is inserted into the force transmission member; and a rotatable coupling which is provided between the end effector and the control wire, and is coupled rotatably to the end effector with respect to the control wire.

Abstract: A system for closing an opening in tissue includes a closure element having a coiled body and a plurality of tissue engaging portions disposed about at least a portion of the body, the body being formed of a resilient material. The system also includes a clip applier apparatus that is configured to deploy the closure element into the tissue.

Abstract: Device, system and method for drawing together patient tissue. A tether loop is coupled to a first end loop and a second end loop. The first end loop and the second end loop each have an end and are resiliently biased to coil when deployed from a delivery catheter. When positioned within the delivery catheter the first end loop and the second end loop become substantially linear. Upon deployment from the delivery catheter the end loops coil and the first end passes through a first piece of tissue while the second end passes through a second piece of tissue. Each piece of tissue is captured within the corresponding end loop, the coiling of each of which draws the two pieces of tissue together.

Abstract: The invention provides a system for occluding a left atrial appendage of a patient. The system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. The system can also provide a tissue-grasping tool that is separable from the ring applicator tool.

Abstract: A method of deforming a plurality of surgical fasteners is provided. The method includes the step of providing a surgical instrument having a loading unit supporting the plurality of surgical fasteners in an array, the surgical instrument having a handle, a distal link, an intermediate link, and a proximal link. The method further includes the steps of moving the handle in a direction to pivot the intermediate link to a position in which the distal link, intermediate link, and proximal link have a fully-extended position, compressing a spring disposed adjacent the proximal link, deforming the surgical fasteners, moving the handle further in the direction, pivoting the intermediate link to another position in which the distal link, intermediate link, and proximal link have a deflected position and releasing the surgical fasteners from the loading unit.

Abstract: A tissue clipping apparatus, comprises a flexible, elongate member, a proximal end of which remains external to the body accessible to a user while a distal end of the flexible member is inserted into the body to a location adjacent to target tissue to be clipped and a control wire extending through the flexible member in combination with a capsule releasably coupled to a distal end of the flexible member and a clip a proximal portion of which is received within the capsule. A joint releasably coupling the clip to the control wire, includes a yoke extending around a proximal end of the clip and a frangible link which fails when subject to a predetermined force to separate the clip from the control wire.

Abstract: Some embodiments relate to a clip comprising: a base portion; first and second opposed arms coupled to the base portion; and first and second opposed jaws coupled to the respective first and second arms, the first and second opposed jaws each having an inwardly extending portion that extends towards the base portion; wherein at least the base portion is formed of a shape memory alloy tending to force the first and second arms toward each other when a temperature of the base portion meets or exceeds a transformation temperature of the base portion.

Abstract: An apparatus for application of surgical clips to body tissue has a handle portion; a body extending distally from the handle portion; a plurality of surgical clips disposed within the body; and a jaw assembly mounted adjacent a distal end portion of the body. The jaw assembly includes first and second jaw portions movable between a spaced-apart and an approximated position. The apparatus also has a wedge plate longitudinally movable between the first and the second jaw portions, a clip pusher configured to individually distally advance a surgical clip to the jaw assembly while the jaw portions are in the spaced apart position; an actuator at least partially disposed within the body and longitudinally movable in response to actuation of the handle portion; and a jaw closure member positioned adjacent the first and second jaw portions to move the jaw portions to the approximated position.

Abstract: A right angle clip applier apparatus including a distal clip applying mechanism and a proximal advancing mechanism positioned in a handle assembly. The clip applying mechanism includes a feed rod interfacing with a cartridge for the advancing and applying of clips on tissue portions. A plurality of clips are enclosed in the apparatus. The advancing mechanism is actuated by a lever in the handle assembly which creates a drive force that repositions the feed rod and clips. Each actuation of the lever applies a first clip and advances clips to a new position in a distal direction. The clip applying mechanism can be utilized at any angle and can be rotated through 360 degrees while holding the handle in a fixed position. An empty clip indicator is provided.

Abstract: An endoscopic treatment tool according to the present invention is an endoscopic treatment tool which is inserted into hollow organs via the mouth, nose, anus, or other natural orifice of the patient and performs suturing treatment within the hollow organs or abdominal cavities, includes: a hollow organ lining support which is smaller than the smallest diameter of a passage from a natural orifice of the hollow organ, the hollow organ lining support being able to expand so as to have a diameter larger than the smallest diameter of the passage from the natural orifice of the hollow organ.

Abstract: A compression tool is configured to compress one or more components of a delivery device, such as a closure element and one or more flanges of a pusher tube. The compression tool includes clamping means configured to close or release with rotation of actuating means (e.g., rotating means). In a closed position, the clamping means can sufficiently compress the one or more components of the delivery device so that a technician can easily position a garage tube about the compressed delivery device components. The assembled delivery device (or assembled garage tube) can then be removed from the compression tool upon reverse rotation of the actuating means, and subsequent opening of the clamping means.