Abstract: Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures are used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment of one or more vascular occlusion devices via a through-and-through percutaneous procedure that leaves the vascular occlusion device or devices in a through-and-through condition.

Abstract: There is provided a device to secure a prosthesis, such as a stent graft, to the internal wall of a body lumen. The device is formed from two elongate elements each comprising a central portion with at least one arm extending therefrom. The central portions of the elements abut. Optionally, the central portions are joined together, optionally by a joining element which can act as a hinge. The terminal end of each arm can be shaped for engagement with the inner surface of the body lumen. The device is reversibly interchangeable between a first folded configuration and a second deployed or open configuration. The device is preferably attached to the sleeve of a stent graft independent of the stents which are preferably ring stents. A stent graft comprising the device is also described.

Abstract: Embolic implants, delivery systems and methods of manufacture and delivery are disclosed. The subject implants are deployed in two stages. If sized properly as observed in the first stage, they are deployed to the second stage and detached. If not sized properly in/at the first stage, the implants are designed to be withdrawn and replaced with a more appropriately sized implant or another treatment option selected. Some of the implant configurations may be withdrawn even after the second stage deployment as well.

Abstract: A jaw closure mechanism for use in a surgical clip applier having first and second jaws movable relative to one another between a spaced-apart position and an approximated position to form a surgical clip about tissue. The jaw closure mechanism includes first and second eccentric wheels rotatably coupled to the respective first and second jaws. Each of the wheels includes a center and a pivot point that is offset relative to the center. A cable is disposed about each of the wheels. The cable is engaged to the first wheel at a first engagement point and to the second wheel at a second engagement point such that, upon application of a drive force to the cable, the wheels are rotated and displaced relative to the respective jaws from a first position to a second position to urge the jaws from the spaced-apart position to the approximated position.

Abstract: Self-locking knotless sutures and associated methods are disclosed. A system for securing tissue includes a monofilament and a braid having a fixed end and a capture end. A first end of the monofilament is connected to the fixed end of the braid. A second end of the monofilament opposite the first end is a free end. The capture end of the braid has a first opening and a second opening. The monofilament and braid are structured and arranged for the free end of the monofilament to be inserted into the first opening, passed through a tunnel formed by the braid, and passed out of the second opening, all while moving in a first direction. After insertion of the monofilament into the braid, the braid prevents movement of the monofilament in a second direction opposite the first direction to prevent the monofilament from being pulled out of the braid.

Abstract: Various surgical instruments for laparoscopic procedures are provided for aspirating and retracting a hollow organ such as a gallbladder. The surgical instruments include a needle body and an anchor coupled to the needle body. The anchor is adapted and configured for engaging and retracting the hollow organ, and can be held and deployed from within the needle body or from an outside surface of the needle body. The needle body defines an aperture for permitting aspiration of contents of the hollow organ.

Abstract: A ligature device and method of use are disclosed. More specifically, a ligature device capable of maintaining a ligature band in an elongated position, applying a preformed ligation band to an object to be ligated, manually releasing the ligation band from an elongated position, and securing a ligation band in a tensioned position is described. The ligation device may be used to apply ligation bands to various body parts of various animals.

Abstract: A suture insertion device is provided for positioning a suture inside a layer of subcutaneous tissue from a remote access point. A tether insertion device is provided for positioning a tether within subcutaneous tissue for operating on the suture from a remote access point. The suture insertion device and the tether insertion device cooperate to form the suture into a tissue-supporting sling useful for performing various surgical procedures, including but not limited to plastic surgery such as mid face lifts, neck lifts, brow lifts, under eye lifts, breast lifts, and organ repositioning.

Abstract: A magnetically coupled, implantable pump system comprises an external controller and an implantable device. A non-implantable magnet in an external controller produces a magnetic field that couples the non-implantable magnet to a magnet in the implantable device. A non-implantable motor moves the non-implantable magnet in a rotational direction. When the non-implantable magnet moves in the rotational direction, a piston coupled to the magnet moves within the implantable device. As the piston moves, an amount of fluid from a reservoir in the implantable device moves out of the reservoir and into an inflatable portion of a gastric band. The implantable device may also move fluid out of the inflatable portion of the gastric band.

Abstract: In some embodiments, a method comprises disposing a portion of a flexible fastening band into contact with a first bone portion and into contact with a second bone portion. The portion of the flexible fastening band having a substantially uniform shape configured to substantially compliment a shape of the first bone portion and a shape of the second bone portion. The method further includes inserting the portion of the flexible fastening band into a fastener and advancing the portion of the flexible fastening band through the fastener until the first bone portion and the and the second bone portion are stabilized.

Abstract: The present invention is specifically directed to a heart occlusion device with a self-centering mechanism. The heart occlusion device includes two separate uniquely shaped wires 12, 14, each forming shapes that mirror the respective wire's shapes. Each wire forms half-discs or quarter-discs that together form a distal disc and a proximal disc. In other versions, the device includes four separate wires, each mirroring its neighboring wire and forming a proximal and a distal quarter-disc. In the versions with four wires, the quarter-discs of each wire together form proximal and distal discs. The distal disc and proximal disc are separated by a self-centering waist. The proximal disc is attached to a hub comprising a screw mechanism. A similar hub is optional on the distal disc. The discs further include coverings which form a sealant to occlude an aperture in a tissue.

Abstract: Generally described herein are automatic, self-adjusting, gastric banding systems and improvements thereof, that are capable of automatically relaxing and contracting in response to a large bolus passing through the area of a patient's stomach constricted by a gastric band. Alternatively, and/or in addition in one or more embodiments, the gastric banding systems described herein may also help prevent pouch dilatation and/or erosion. The apparatus and systems described herein aid in facilitating obesity control and/or treating obesity-related diseases while generally being non-invasive once implanted. Furthermore, certain embodiments of the self-adjusting gastric banding systems disclosed herein are automatically adjustable without complicated fluid control mechanisms, flow rate limiting devices, and/or valves. The automatic adjustments may also be made in response to other changes in the patient's esophageal-gastric junction, for example, in response to size, shape, and or location changes.

Abstract: The invention relates to a surgical clip for minimally invasive surgery and to a device for clamping organic tissue, consisting of a first clamping bar corresponding with a second clamping bar, wherein the first clamping bar and the second clamping bar each have, on both sides on their base, shoulders for guiding them into a cartridge, and one clamping bar has a continuous retaining bore into which, in order to clamp the organic tissue, a retaining pin provided on the other clamping bar engages with a force fit and form fit, the first clamping bar (1) is mounted by means of clamp pressing in a cartridge (11), and the second clamping bar (2) with the continuous retaining bore (3) has, at its lower end, an arm (5) which, upon joining to the first clamping bar (1), slides with a form fit under the shorter first clamping bar (1) with the retaining pin (4), thus clamping the organic tissue, or the first clamping bar (1) with the retaining pin (4) at its lower end has the arm (5) which, upon joining to the second c

Abstract: An attachable clamp for use with a surgical instrument is disclosed. The attachable clamp comprises a body portion, a first jaw member, a second jaw member and an actuation mechanism. The body portion defines a longitudinal axis and has attachment members configured to attach to an elongate portion of a surgical instrument. Each of the first jaw member and second jaw member extends distally from the body portion. The actuation mechanism is disposed in mechanical cooperation with at least one of the first jaw member and the second jaw member. Actuation of the actuation mechanism moves at least one of the first and second jaw members between an approximated position and an open position with respect to the other jaw member.

Abstract: The invention relates to an occluder for closing a passage in a circulatory system comprising an expandable fixation unit for fixing the occluder on the passage, wherein the occluder can be transferred in the passage from a compact appearance into an expanded appearance. The occluder has a distal and a proximal axial part, in which the fixation unit is pivotally held. According to the invention, the fixation unit comprises distal fixation arms and proximal fixation arms, wherein the distal fixation arms are pivotally held in the distal axial part and the proximal fixation arms are pivotally held in the proximal axial part. The distal and the proximal fixation arms have free ends, which are interconnected by means of connecting members that can be moved relative to the fixation arms, wherein in each case a distal fixation arm is connected to a proximal fixation arm located diagonally opposed thereto. Said occluder is suited in particular for closing a ventricular septal defect (VSD).

Abstract: An apparatus for treating a hollow anatomical structure comprises an implant comprising a plurality of bioabsorbable fibers. The implant has a compressed state in which the implant can fit within a cylindrical tube having an inside diameter of 8 French or less. The implant is expandable from the compressed state to an expanded state in which the implant has sufficient size to span the inside diameter of a cylindrical tube having an inside diameter of 12 French or greater.

Abstract: Apparatus and methods for treating a hollow anatomical structure comprises an implant sized for insertion into a hollow anatomical structure. The implant comprises a plurality of loose, bulked fibers. The fibers are formed from one or more bioabsorbable materials. Upon implantation, the apparatus causes a partial occlusion of the hollow anatomical structure, followed by a complete or substantially complete occlusion.

Abstract: The instant disclosure is directed to devices and methods for deploying a biased occlusion clamp. In addition, the present disclosure includes devices and methods for deploying a biased occlusion clamp using robotics. Moreover, the present disclosure includes devices and methods for reducing the force necessary to open an occlusion clamp without permanently compromising the clamping force of the clamp itself.

Abstract: An apparatus for applying surgical clips to tissue includes a handle assembly having a trigger and a shaft extending therefrom. The shaft includes at least one surgical clip therein. Each clip includes a pair of legs connected by a crossbar. Each of the pair of legs has an inwardly and an outwardly facing surface, the outwardly facing surface having a raised profile protruding therefrom and extending longitudinally therealong. A jaw assembly is disposed at a distal end of the shaft and includes first and second opposed jaws moveable between a spaced apart and an approximated position. Each jaw defines a recess extending longitudinally along opposing inner surfaces thereof. Each recess defines a longitudinally extending groove having a profile substantially complementary to the raised profile of the legs of the clips. The legs of each clip are positionable at least partially within respective grooves of the recesses of the jaws.

Abstract: A surgical staple-clip including a clip component and a securing member is used in a wide range of surgical procedures. The staple-clip may be introduced to a surgical site in an un-assembled condition through a small port or trocar. An applier for the staple-clip comprising a pair of opposed jaw-like channels is provided to position and apply the clip component and the securing member. The clip component is positioned around a target tissue and is compressed or clamped upon the tissue using only the force required for a specific surgical procedure such as occlusion, ligation or fixation. When the clip component is properly applied, the securing member is urged forward and over the clip component to secure the staple-clip. The clip component may include traction enhancement features such as surface interruptions, bumps, valleys and ridges.

Abstract: Devices and methods for forming and securing a tissue plication are disclosed herein. In one aspect, a tissue manipulation device is described that includes a first jaw member pivotally coupled to a distal end of an elongate shaft and having an articulating portion located distal to the proximal end of the first jaw member. The device also includes a second jaw member pivotally coupled to the first jaw member such that the jaws move in a first plane, and a fastener delivery member attached to the second jaw member. The articulating portion of the first jaw member is configured to move the first and second jaw members between a straight configuration in which a longitudinal axis of the elongate shaft is contained within the first plane and an articulated configuration in which the longitudinal axis of the elongate shaft is transverse to the first plane.

Abstract: Described here are devices, systems and methods for closing the left atrial appendage. Some of the methods described here utilize one or more guide members having alignment members to aid in positioning of a closure device. In general, these methods include advancing a first guide having a first alignment member into the left atrial appendage, advancing a second guide, having a second alignment member, into the pericardial space, aligning the first and second alignment members, advancing a left atrial appendage closure device into the pericardial space and adjacent to the left atrial appendage, and closing the left atrial appendage with the closure device. In these variations, the closure device typically has an elongate body having a proximal end and a distal end, and a closure element at least partially housed within the elongate body. The closure element comprises a loop defining a continuous aperture.

Abstract: In a background-art medical gripping device, when a wall surface of an in vivo tissue has a large tear, a side portion of the tear can be gripped by the gripping device, but the other side portion opposed to the side portion cannot be gripped simultaneously. Therefore, to close the tear, complicated operation is required to be performed using plural gripping devices. A medical gripping device according to the present invention includes a fixed clip, a pair of movable clips made from an elastic material and provided to face the fixed clip, the movable clips having lower ends fixed to the fixed clip and the other ends opened, and a control mechanism which shifts from each other a timing at which a gripping target is gripped between one of the movable clips and the fixed clip and a timing at which the target is gripped between the other movable clip and the fixed clip.

Abstract: Devices and methods for tissue restoration. In an exemplary embodiment of an implantable restraining device of the present disclosure, the device comprises a first engaging component and a second engaging component at least substantially parallel to one another, a first swivel arm, comprising a first fixed arm, a first expandable arm, and a first hub, and a second swivel arm, comprising a second fixed arm, a second expandable arm, and a second hub.

Abstract: A pusher-occlusive coil delivery assembly 10 that is advanced through a microcatheter 40 to the desired vascular site within a patient. The delivery assembly 10 includes a pushwire 12 which interlocks with the occlusive coil 11 which can be manipulated to detach the occlusive coil 11. When the assembly 10 is positioned at the site, the pushwire 12 is advanced to allow the interlock joint 14, 15 to move out of the delivery sleeve 13 to uncouple the pushwire 12 and the occlusive coil 11.

Abstract: A delivery system for delivering an occluding device to a body lumen comprises an elongated shaft having a proximal end and a distal end, a delivery means for delivering the occluding device to a desired location within the body lumen, and a flexible atraumatic tip on the distal end of the elongated shaft. The distal end of the elongated shaft is insertable into the body lumen. The atraumatic tip is configured to guide the elongated shaft through the body lumen while avoiding perforation of the body lumen.

Abstract: An adjustable band or clamp or non-adjustable clamp is placed about the greater curvature of the stomach in a vertical orientation. The band or clamp completely compartmentalizes the stomach between a small vertical pouch and the fundus and body of the stomach. The fundus and body of the stomach are excluded from nutrients and are separated from a long narrow channel where the food travels. A small passage at the level of the antrum allows gastric juices to empty from the fundus and body of the stomach. The clamp may be applied during open surgery in laproscopic surgery or using a single port technique, or through any natural orifice in NOTES (Natural Orifice Transluminal Endoscopic surgery) or using a hybrid surgical technique.

Abstract: A surgical securement apparatus for selectively securing one or more ends of a cord while allowing adjustments in the tension or a full release of the cord intermittently after a prolonged period of time. A surgical securement and marking system utilizing one or more surgical securement apparatus that are color-coded to convey information about the associated intercorporeal structures. The surgical securement apparatus can be particularly adapted for use in securing intracorporeal structures such as nerves, blood vessels, and tendons during a surgical procedure. An extender tube connected to the surgical securement apparatus enables securement of intracorporeal structures within the surgical site from outside the surgical site. A threading assembly for use with the surgical securement apparatus that is adapted to facilitate threading of a cord along the length of the surgical securement apparatus.

Abstract: Apparatus and methods for delivering a surgical clip to a patient during a minimally invasive surgical procedure are disclosed herein. An exemplary apparatus for isolating an atrial appendage of a patient includes a surgical clip that locks onto the atrial appendage of the patient, and a surgical clip applicator that releasably engages the surgical clip. The surgical clip can include a top portion and a bottom portion. The surgical clip applicator can include a first flexible flap and a second flexible flap. The first and second flexible flaps can be sufficiently rigid to prevent the surgical clip from falling off of the surgical clip applicator when the surgical clip is engaged to the surgical applicator and the surgical clip applicator is in a relaxed state, and sufficiently flexible to facilitate separation of the surgical clip from the surgical clip applicator when the surgical clip is locked onto the atrial appendage.

Abstract: A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.

Abstract: A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.

Abstract: Provided are a gastric band securing device and a gastric band including the gastric band securing device which includes: a main body configured to be attached to a portion of a stomach; and a linking part having one end configured to be connected to the main body, and the other end configured to be connected to the gastric band configured to wrap around an inlet of the stomach.

Abstract: Intragastric implant devices for obesity treatment are disclosed. The device is passive and does not autonomously change shape, but instead reacts to movement of the stomach to induce satiety. The device includes a series of connected, articulated clips that plicate the stomach wall nondestructively (no puncturing through the gastric wall) such that the overall volume of the stomach is reduced. Cam-shaped clamping surfaces prevent slippage of the stomach tissue from within the clips. Methods of implant are disclosed including delivering the device through a transoral delivery tube and advancing the device through the esophagus to be deployed within the stomach. Removal of the device occurs in the reverse.

Abstract: An adjustable band or clamp or non-adjustable clamp is placed about the greater curvature of the stomach in a vertical orientation. The band or clamp completely compartmentalizes the stomach between a small vertical pouch and the fundus and body of the stomach. The fundus and body of the stomach are excluded from nutrients and are separated from a long narrow channel where the food travels. A small passage at the level of the antrum allows gastric juices to empty from the fundus and body of the stomach. The clamp may be applied during open surgery in laproscopic surgery or using a single port technique, or through any natural orifice in NOTES (Natural Orifice Transluminal Endoscopic surgery) or using a hybrid surgical technique.

Abstract: A tissue clipping device includes (a) a first body extending from a proximal end to a distal end and including a first channel extending therethrough and (b) a plurality of first arm elements, each of the plurality of first arm elements extending radially into the first channel from a first end coupled to the first body to a second end proximal of its first end so that tissue drawn into a distal end of the first channel proximally beyond the second end of the plurality of first arm elements is compressed between each of the plurality of first arm elements and retained in the first channel.

Abstract: Apparatus and methods are disclosed for occluding an anatomical structure including an occlusion apparatus having first and second beams and at least one connector for connecting the respective ends of the beams together. The occlusion apparatus may be adapted for use in a deployment device having a pair of jaws and optionally having a respective pair of shuttle bodies for releasably connecting an occlusion apparatus to the jaws while in an open position and for releasing the occlusion device from the jaws while in a closed position. A system for occluding an anatomical structure is also disclosed that includes an occlusion apparatus and a deployment device for holding the occlusion apparatus in an open position for locating the occlusion device adjacent the anatomical structure to be occluded and then moving the occlusion apparatus to a closed position and locking the occlusion apparatus in the closed position.

Abstract: Embodiments for a device, system and method for occluding an opening in a septum. Embodiments of the device can include a first control component, a first elongate member that extends from the first control component, a second elongate member, a connecting member that positions the first elongate member adjacent the second elongate member and a retraction member releasably coupled to the first control component. The retraction member can be used to change a relative position of the first elongate member and the second elongate member of the device.

Abstract: A hemostatic clip includes: a clip body formed by folding an intermediate section of a belt-like member; and a holding tube. The clip body includes: a first member formed of a first metallic material that is elastically deformable; and a pair of second members that are formed of a second metallic material having a lower elastic strain limit than an elastic strain limit of the first metallic member and are connected to respective both ends of the first member. The holding tube is configured to change an opening width of the clip body by holding part of the clip body in the holding tube.

Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

Abstract: The present invention relates to a device for intermittently obstructing a bodily opening, such as a gastric opening, and includes a proximal member connected to a distal member by a tether. The proximal member includes an apron member surrounding a first occluding member, which is formable from an elongated and narrower configuration to a contracted or expanded but wider configuration. When employed in the stomach, the device of the present invention is arranged transluminally, with the distal member disposed in the duodenum and the proximal member disposed against the pyloric valve, intermittently occluding the pyloric valve and preventing or delaying the flow of gastric contents through the pyloric valve. In certain embodiments, a reservoir may be included for releasing a substance of interest, for example for releasing insulin from a reservoir disposed in the distal member. Sensors, actuators, and data transmission devices may also be included.

Abstract: Devices, systems, and methods for treating a heart of a patient may make use of structures which limit a size of a chamber of the heart, such as by deploying a tensile member to bring a wall of the heart toward (optionally into contact with) a septum of the heart. The implant may include an electrode or other structure for applying pacing signals to one or both ventricles of the heart, for defibrillating the heart, for sensing beating of the heart or the like. A wireless telemetry and control system may allowing the implant to treat congestive heart failure, monitor the results of the treatment, and apply appropriate electrical stimulation.

Abstract: A surgical clamp for forming a clamping loop around a bodily lumen is disclosed. The clamp is deliverable through keyhole surgery. The clamp comprises: an elongate body comprising an elongate deformable layer having a first hardness and an elongate core having a second hardness, the first hardness less than the second hardness; a leading portion comprising a gripper, the gripper having an open mouth gripably engageable with the deformable layer to form the clamping loop; and a trailing portion. The elongate body joins the trailing portion to the leading portion. The elongate body is biased to move from a constrained generally straight condition within a delivery device to an unrestrained curled condition within a patient.

Abstract: An applying forceps for a clip comprises two forceps legs which can be pivoted relative to each other and comprise, on their sides facing each other or facing away from each other, each a depression or a projection for receiving a clip, wherein the depression or projection extends along an arcuate curve.

Abstract: A surgically implantable injection port has a tissue in-growth promoting surface associated with a fluid conduit that is coupled to the injection port. The injection port includes a housing, a fluid reservoir defined in part by the housing, a needle penetrable septum, a fluid conduit in communication with the reservoir, and a tissue in-growth promoting surface coupled to the fluid conduit. The tissue in-growth promoting surface may be provided by surgical mesh wrapped around the conduit or through which the conduit is threaded. The injection port and the fluid conduit may be used as part of a gastric band system or some other type of system.

Abstract: The invention describes methods and apparatus for creating permanent occlusion of body lumens such as the fallopian tubes. The methods and apparatus use non-surgical approaches to deliver permanent implants which create acute occlusion of desired body lumens which resolve to permanent occlusions of the lumens.

Abstract: Apparatus and methods are disclosed for occluding an anatomical structure including an occlusion apparatus having first and second beams and at least one connector for connecting the respective ends of the beams together. The occlusion apparatus may be adapted for use in a deployment device having a pair of jaws and optionally having a respective pair of shuttle bodies for releasably connecting an occlusion apparatus to the jaws while in an open position and for releasing the occlusion device from the jaws while in a closed position. A system for occluding an anatomical structure is also disclosed that includes an occlusion apparatus and a deployment device for holding the occlusion apparatus in an open position for locating the occlusion device adjacent the anatomical structure to be occluded and then moving the occlusion apparatus to a closed position and locking the occlusion apparatus in the closed position.

Abstract: Methods and devices for approximating tissue are disclosed. The methods and devices utilize a device for applying an implantable tissue fastener and a variety of implantable tissue fasteners. The tissue-fastening device can be delivered endoscopically and can be adapted to function along side or in conjunction with a flexible endoscope. In general, the device can include a flexible shaft having an implantable tissue fastener applier disposed at a distal end of the shaft and a handle for operating the implantable tissue fastener applier disposed at a proximal end of the shaft. A variety of self-deploying implantable tissue fasteners can be used with the tissue fastener applier device.

Abstract: A uterine clamp for stemming or stopping bleeding of a hemorrhagic uterus. A pair of inflatable bladders are nested in a pair of rigid shells shaped and sized to fit the anterior and posterior of a uterus without impinging on the uterine horn on placement of the shells nesting the bladders in mirrored spaced opposition to one another in front of and behind the uterus and the broad ligament supporting the uterus. At least one latch on an upper end of one shell and at least one latch catch in the upper end of the other shell provide an interlock for releasably interlocking the opposed shells in front of and behind the broad ligament anteriorly and posteriorly against the uterus for inflation of the bladders to compress the uterus to stem or stop hemorrhage.

Abstract: A clipping device includes (a) a shaft defining a lumen therethrough from a proximal end which, during a procedure remains outside the body accessible to a user and a distal end including a distal opening which, during a procedure is inserted into the body to a position adjacent to target tissue; (b) a flexible clip deployable from the distal opening, when in an unconstrained state, the clip assuming a shape selected to clip tissue and prevent a flow of fluid therethrough wherein, while residing within the lumen the clip is held substantially straight by an inner diameter of the lumen; (c) a control wire extending through the lumen from the proximal end to the distal end thereof; and (d) a release mechanism connecting the control wire to the clip during deployment of the clip and disconnecting the control wire from the clip after deployment thereof.

Abstract: The invention relates to a device for the implantation of microcoils (3, 7, 11, 12) into body cavities and blood vessels, in particular aneurysms, with said microcoils (3, 7, 11, 12) comprising wires forming a plurality of windings (4), at least one microcoil serving as occlusion helix (3) for the occlusion of the body cavity or blood vessel, and the device consisting of a catheter, one or several microcoils (3, 7, 11, 12) movably arranged in longitudinal direction within the catheter and at least one securing means (10) passing at least partially through the lumen (9) of the occlusion helix (3), with said securing means (10) being fixed in its end areas inside the microcoils (3, 7, 11, 12). Such a fixation of the securing means (10) is achieved in at least one end area by providing a frictional connection with the microcoil (3, 7, 11, 12) in such a manner that this connection is detachable from the microcoil (3, 7, 11, 12) when a certain tensile force acting on the securing means (10) is exceeded.