Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member.

Abstract: A closure device for closing a bodily passageway is provided. The device includes first and second frames and first and second crossbars. A sheet of biocompatible material is attached to one or more of the frames. The first crossbar extends across the first frame and has terminal crossbar ends connectively linked to separate sites on the first frame; the second crossbar is similarly linked to the second frame. The crossbars are attached to each other at a connection point, and they are each configured to bend away from the connection point when the closure device is deployed to close a bodily passageway. A method of making the closure device is provided, as well as a method for closing a bodily passageway using such a device. Further, a closure device assembly is provided, including a closure device, a delivery catheter housing, and a delivery release member.

Abstract: Device for removing prostate tissue from within the urethra, the device including a plurality of arms, and an actuating mechanism coupled to the arms, the arms being rotatable about a longitudinal axis of the urethra, the arms being divided into arm pairs, each of the arm pair being apart from each other in a first configuration and attempting to get closer to each other, in a second configuration, wherein the device is inserted in the urethra toward the prostate, in the first configuration, and wherein after the device is placed adjacent to the prostate, within the urethra, the actuating mechanism moves the arms to the second configuration, thereby pinching the prostate through the urethra.

Abstract: At least on aspect of the present disclosure relates to a surgical clamping device, comprising first and second shaft members each having a jaw member disposed at a distal end thereof, a gripping member disposed on the first shaft member, and a gear system disposed on the second shaft member and configured to receive the gripping member and incrementally lock the gripping member in at least one predefined position.

Abstract: A device for occluding a blood vessel, comprises a blunt dissection needle and a first occlusion clip releasably mounted to a distal end of the blunt dissection needle, the first occlusion clip being biased to assume a clamped configuration in combination with a retaining element which, in a first configuration, retains the first occlusion clip in an insertion position against an outer surface of the blunt dissection needle and, in a second configuration, releases the first occlusion clip to assume the clamped configuration.

Abstract: Disclosed herein is a stent for prostatic urethra expansion which does not generate bladder stones, is removable without causing injury on a urethra, and does not generate atrophy of a prostatic urethra even after removal. The stent for prostatic urethra expansion include a stent unit including a cylindrical body with space parts formed by knotting or crossing shape memory alloy wires and bending terminals formed at both ends of the cylindrical body, a pair of hook wires passing through the space parts and knotted to the shape memory alloy wires, both ends thereof being wound on the bending terminals and then being bent upwardly to produce hooks, and a pair of hanging strings arranged in opposite directions to form a hanging knot. The stent for prostatic urethra expansion does not move into the bladder, and expands and maintains a lumen of the stenosed prostatic urethra, thereby reducing post-operative recovery time.

Abstract: A medical clamp includes a lower arm assembly, an upper arm assembly, and a belt. The upper arm assembly is pivotally connected to the lower arm assembly. The lower arm assembly and the upper arm assembly are configured for clamping relative to one another. The belt is connected to the lower arm assembly and the upper arm assembly and is configured for forming a loop therebetween.

Abstract: The invention relates to a medical restriction device for hollow organs of a body, having a longitudinal flexible element having a first and a second end, a closure device locking the longitudinal element annularly in a predetermined diameter position, and a tip as an insertion aid at the first end of the longitudinal element for placing the restriction device on the hollow organ, wherein the tip comprises a reinforcing core made of rigid material, wherein an opening is provided at the second end of the longitudinal element as part of the closure device, the tip can be inserted with the first end of the longitudinal element into the opening at the second end of the longitudinal element for locking the closure device, and the tip is fixedly connected to the first end; and can be cut off after locking the longitudinal element by the closure device.

Abstract: A surgical instrument and actuation mechanism comprises an end effector, the end effector including opposing faces, and a positioning slot. The positioning slot includes a linear portion and a radial portion. In accordance with one aspect, the surgical instrument further comprises an actuation mechanism engaged with the positioning slot, wherein the opposing faces of the end effector move in a parallel manner when the actuation mechanism moves within the linear portion of the positioning slot, and wherein the opposing faces of the end effector move in an angular manner when the actuation mechanism moves within the radial portion of the positioning slot.

Abstract: A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.

Abstract: A surgical ligation clip for double ligating a vessel, duct or other fluid carrying structure and a method for double ligating such structure.

Abstract: A device and method for ligating diseased tissue. The device includes a flexible, substantially tubular sleeve adapted to be positioned around tissue to be ligated and having first and second ends, and at least one anchoring member coupled to the tubular sleeve having an anchoring element positioned substantially adjacent to the first end. The anchoring member has at least one projecting element extending therefrom and adapted to engage healthy tissue when the ligation device is positioned around the tissue to be ligated. The device further includes an elastic element positioned around the periphery of the sleeve and adapted to apply a constrictive force around the periphery of the sleeve.

Abstract: Surgical clips and devices for ligating tissue, as well as methods related to the same, are generally provided. In one exemplary embodiment a surgical clip includes a pair of opposed first and second leg members and a knee portion formed between the leg members' proximal and distal ends. The leg members can include at least one tissue-grasping element formed on respective inner surfaces, and at least one raised area located on a portion of respective generally planer outer surfaces. The clip can also include an apex having opposed ends that join the proximal ends of the first and second leg members and at least one notch formed on an inner surface of the apex. The raised area of the leg members can be disposed distal to the apex and proximal to the knee portion. Other embodiments of clips and methods for ligating tissue are also provided.

Abstract: A styptic device (10) for substantially hemostatically sealing a percutaneous puncture (12) in a blood vessel (14) of a patient (11), the styptic device (10) comprising: a base (16); a main compression element (18) extending from the base (16), the main compression element (18) defining a main compression surface (24) compressible against the patient (11); and an auxiliary compression element (20) removably attachable to the base (16), the auxiliary compression element (20) defining an auxiliary compression surface (26) compressible against the patient (11).

Abstract: Medical systems, devices and methods are provided for engaging tissue, e.g. for clipping tissue, closing a perforation or performing hemostasis. Generally, the medical system including a housing, first and second jaws rotatable relative to the housing, a driver, and an elongate drive wire. The elongate drive wire may be disconnected from the driver, first and second jaws, and the housing, which are left in vivo engaged with the tissue.

Abstract: A device and method for treating bodily diseases and/or conditions, for example, varicose veins, tumors and aneutisms including for example insertion of a blocking device toward a target destination using a catheter and delivery of sclerosing or other agents to the vessel while maintaining minimal, for example zero pressure in the treatment area, The blocking device may prevent treatment materials, embolisms, debris etc., from entering the upstream section of vessel. The blocking device may include, for example, a cap or other concave shape and may be expandable or extendible towards the vessel walls.

Abstract: The invention provides an intracardiac occluder, which has biological tissue scaffolds as occlusion shells, for the percutaneous transluminal treatment of an intracardiac defect. The intracardiac occluder includes a proximal support structure supporting the proximal occlusion shell and a distal support structure supporting the distal occlusion shell. In one embodiment, biological tissue derived from the tunica submucosa layer of the porcine small intestine forms the occlusion shells.

Abstract: A weasand-ligating clip (10) made as a one-piece molding, the clip comprising two portions (11) hinged together at one end by a film hinge (13), and including a closure system (15, 16) at the other end, the portions (11) having teeth that clamp against the weasand when the clip is closed, the clip being characterized by the fact that a major longitudinal dimension (L) of the clip measured from the film hinge to the closure system is less than 45 mm, or indeed less than 42 mm, and better less than 40 mm.

Abstract: A narrow profile surgical ligation clip has two legs with clamping surfaces joined by a hinge near the proximal ends, allowing the clip to reversibly open and close. A locking mechanism is proximal to the hinge to bias or lock the clip closed, including first and second jaw structures spaced on opposite sides of a longitudinal axis of the clip thereby defining a locking space therebetween. In one embodiment, a wedge or buttress body moves by application of an external force applied to a proximal end of the clip towards the hinge to move into the locking space such that one or more outer surfaces or projections of portions of the body fit into or abut against complementary surfaces or other parts of the locking mechanism or clip assembly to bias or lock the clip in a closed position and provide additional closing force to the inner clamping surfaces.

Abstract: A method of occluding an appendage of the heart with a clamp including at least first and second elongate clamping portions, the first and second elongate clamping portions including tissue engaging surfaces that promote tissue ingrowth. The method includes implanting the clamp by positioning the first and second elongate clamping portions on opposite sides of the appendage. At least one of the first or second elongate clamping portions is biased toward the other of the first and second elongate clamping portions to place the clamp into a clamping position on the appendage. Tissue ingrowth into the tissue engaging surfaces retains the clamp in place on the appendage.

Abstract: A surgical ligation clip capable of remote deployment through a cannula to engage an anatomical structure.

Abstract: In a medical clip consisting of a platelet of an elastic bio-compatible material, the platelet is provided with a central H-shaped cut-out so as to form a frame structure with tongues extending from the frame structure toward each other and having adjacent front edges forming grasping elements, and the frame structure is curved and elastically biases the front edges toward each other.

Abstract: A ligature device and method of use are disclosed. More specifically, a ligature device capable of maintaining a ligature band in an elongated position, applying a preformed ligation band to an object to be ligated, manually releasing the ligation band from an elongated position, and securing a ligation band in a tensioned position is described. The ligation device may be used to apply ligation bands to various body parts of various animals.

Abstract: Apparatus for percutaneously occluding a hollow structure, said apparatus comprising: an occluder, said occluder comprising a first component and a second component, wherein said first component is configured so that it may assume (i) a diametrically-reduced configuration for disposition within the lumen of a hollow tube, and (ii) a diametrically-expanded configuration for disposition adjacent to the hollow structure, whereby to occlude the hollow structure, and further wherein said second component percutaneously connects said first component to a site remote from said first component.

Abstract: A ligature delivery device includes a control member, an elongated shaft, and an end effector attached to the distal end of the elongated shaft. An activation mechanism provides an user-operable connection between the control member and the end effector. In several embodiments, the end effector includes a reverse grasping mechanism. Several embodiments of ligature devices are adapted to be deployed endoscopically and/or translumenally using the reverse-grasping delivery device.

Abstract: A luminal cavity closing device can include a flexible linear shaft, a clamping mechanism which is provided at a distal portion of the shaft and has at least two arms, and a detachment mechanism configured to enable detachment of the clamping mechanism from the shaft. The arms of the clamping mechanism can be configured so as to be insertable into hollow tubular structures located adjacent to and on both sides of a luminal cavity present in a hollow tubular structure bifurcation area. The clamping mechanism operates between an expanded state wherein the interval of the arms is enlarged to a contracted state wherein the interval of the arms is contracted.

Abstract: Implantable devices are designed to provide support to the bulbar urethral region of a patient experiencing incontinence. Surgical methods are utilized to implant the devices, and surgical tools are utilized with the surgical methods.

Abstract: The present embodiments provide apparatus and methods for facilitating closure of a bodily opening. In one embodiment, a tissue retraction member and a closure member are provided. The tissue retraction member is advanced in a distal direction through the bodily opening in a contracted state, and then expanded at a location distal to the opening. The tissue retraction member then is proximally retracted to engage first and second serosal tissue regions at least partially surrounding the opening, thereby causing the first and second serosal regions to be disposed in an adjacent relationship. The closure member then is deployed around first and second mucosal tissue regions, such that when deployed, the closure member imposes a compressive force to hold the first serosal tissue region in a sealing relationship against the second serosal tissue region to facilitate sealing of the opening.

Abstract: An access apparatus is adapted and configured to access an underlying body cavity. The access apparatus includes a sleeve including a plurality of tubules. The tubules are configured and adapted to suction fascia of opposing tissue tracts to facilitate wound closure. A method of using the access apparatus is also provided.

Abstract: An inventive method for performing gastric bypass surgery and a gastric bypass band that is used in conjunction with the surgical method is disclosed. The inventive method involves separating a top portion of the stomach along with the esophagus from the remainder of the stomach, and re-connecting the separated portion to the small intestine to form a gastric pouch of about 20-30 cc in size. The inventive gastric band is placed midway along the gastric pouch to act as a restrictor valve to limit the amount of food passing through the valve. The band also retains food within the gastric pouch to give the patient a feeling of satiety. The band is comprised of an expansion-resistant section combined with a one-way latch mechanism. The latch has a curved orientation so that the band is formed into a radial profile when placed around the gastric pouch.

Abstract: A ligating apparatus includes a clip, a clip connecting member, a clip holding member, an operating wire, an inner sheath member, an outer sheath member and first and second movement restricting portions. The clip ligates a body tissue with arm portions. The clip connecting member connects to a clip base portion. The clip connecting member is inserted through the clip holding member. The operating wire connects to the clip connecting member. The inner sheath member encloses the operating wire to support the clip holding member. The outer sheath member covers an outer periphery of the inner sheath member and freely advances and retreats. The outer sheath member advances and/or retreats to change the degree of opening of the arm portions. The first movement restricting portion restricts the inward movement of the clip holding member. The second movement restricting portion restricts the outward movement of the clip holding member.

Abstract: A surgical loop for constricting or ligating, partially or fully, an anatomic conduit during a surgical intervention. The surgical loop includes an elastomeric tubular body, a curved needle that is attached to one free end of the tubular body to facilitate its insertion through a body tissue containing an anatomic conduit, and a pledget which is frictionally engaged and positionable along the length of the tubular body. The pledget is frictionally engaged with a first portion of the tubular body through a closed-perimeter opening. A second portion of the tubular body is subsequently frictionally engaged or restrained with the pledget through a slot. The pledget is configured with a bias structure which maintains the slot in a biased-closed configuration to engage and restrain the second portion of tubular body.

Abstract: Devices and methods for achieving hemostasis and leakage control in hollow body vessels such as the small and large intestines, arteries, and veins as well as ducts leading to the gall bladder and other organs. The devices and methods disclosed are especially useful in the emergency, trauma surgery, or military setting. In such cases, the patient may have received trauma to the abdomen, extremities, neck or thoracic region. The devices utilize removable or permanently implanted, broad, soft, parallel jaw clips with minimal projections to maintain vessel contents without damage to the tissue comprising the vessel. These clips are applied using devices that are subsequently removed leaving the clips implanted, on a temporary or permanent basis, to provide for hemostasis or leakage prevention, or both. The clips come in a variety of shapes and sizes. The clips may be placed and removed by open surgery or laparoscopic access.

Abstract: The invention describes methods and apparatus for creating permanent occlusion of body lumens such as the fallopian tubes. The methods and apparatus use non-surgical approaches to deliver permanent implants which create acute occlusion of desired body lumens which resolve to permanent occlusions of the lumens.

Abstract: Medical device used to cause hemostasis of blood vessels using a clip arrangement delivered to a target region through an endoscope. Method for using the device to cause hemostasis of a blood vessel through an endoscope. Medical device including a reversibly closeable clip, a locking arrangement, a control wire, a sheath, and a handle with an actuating trigger. Through the endoscope, hemostatic clipping device that is fully reversible and lockable. Hemostatic clip that reversibly targets and clips bleeding ulcers.

Abstract: A clip apparatus for ligature of living tissue is provided. The clip apparatus includes a clip that can be opened and closed multiple times prior to locking in a closed position on the tissue.

Abstract: Patent foramen ovale (PFO) closure clip include two closure members, which may be heart shaped, joined by at least two spaced central connecting members. Each of the at least two spaced central connecting members is attached to each closure member at a location on the periphery of the closure member. The connecting member may be generally square shaped or include other shapes. The clips of the present invention may be formed of various materials, including metals, nonmetallic materials, bioresorbable polymers, spring steel, shape memory materials, bioresorbable shape memory polymers, or combinations thereof. The clips can take various forms depending, in part, upon the distribution of force required to close a given PFO. At least one of the closure members can include a tissue scaffold.

Abstract: An artificial contractile structure generally devised to be used in the medical field to assist the functioning of an organ, includes a support (2) and one or more fibers (5) fixed thereto. The fibers are made of a contractile material which can be activated by an activator so as to provide the structure in a rest or activated position, the activated position being defined with fibers of reduced length compared to their length in the rest position. The structure is adapted to be placed around a hollow part of an organ to be contracted. The fibers are distributed along the support in order to be able to reduce the volume of the hollow part, when the fibers are contracted. The fibers and the activator are designed so that the temperature of fluids or tissues surrounding the organ does not increase above 40° C., preferably 39° C., and more preferably 38° C.

Abstract: Apparatus (90) is provided for use in a stomach of a subject. The apparatus includes a balloon (92), adapted for placement in the stomach, and all anchor (102), coupled to the balloon. The anchor is adapted to prevent the balloon from passing into a duodenum of the subject. The apparatus further includes an inflation tube (96), coupled to the balloon to permit inflation of the balloon, and is adapted to stretch from the stomach to a mouth of the subject to facilitate inflation of the balloon. Other embodiments are also described.

Abstract: Apparatus is provided for use in a stomach of a subject. The apparatus includes a gastric balloon and an anchor coupled to the gastric balloon. The anchor includes a flexible tube, which, when in a relaxed position, is shaped so as to define a portion that prevents the anchor from passing into a duodenum of the subject. The anchor also includes one or more shape-controlling elements coupled to the portion and configured to control a shape of the portion. Other embodiments are also described.

Abstract: Apparatus and methods for promoting hemostasis are provided. The apparatuses and methods have particular applicability with tissue puncture closure devices for sealing percutaneous punctures in arteries. In one embodiment, an apparatus for promoting hemostasis a tube having at least one indentation for holding a hemostatic substance. In further embodiments, the apparatus may further include a carrier tube for forming a lid for the indentation, a retractable sheath for forming a lid for the indentation, or a cover for forming a lid of the indentation. In an alternative embodiment the apparatus for promoting hemostasis comprises a suture provided with a hemostatic substance.

Abstract: An inflatable gastric band incorporates a fluid channel within an outer surface of the band and an inflatable bladder on a stomach-facing side of the band. The gastric band attaches to a double lumen catheter, which communicates with a dual infusion port. One lumen communicates with the fluid channel and one port, while the other lumen communicates with the inflatable bladder and a second port. Injection of fluid into one chamber of the infusion port expands inflatable bladder, allowing adjustment to the diameter of the stoma. Injection of drugs or therapeutic agents into the second chamber allows the infusion of drugs or agents directly into the abdominal cavity of a gastric band recipient. The inflatable bladder can be continuous or segmented. A segmented bladder reduces pinching and/or folding of the inner surface of the gastric band during expansion/contraction, thereby lessening stomach pinching and/or irritation.

Abstract: A medical device including artificial contractile structures generally devised to be used in the medical field. Such structures may be advantageously used to assist the functioning of an organ. The medical device includes an artificial contractile structure having at least two contractile elements (100) adapted to contract an organ, in such way that each of the contractile elements (100) can be in a resting or in an activated position, independently of the position of each other, the activated position being defined with the contractile element (100) constricting the organ and the resting position being defined with the contractile element (100) not constricting the organ, and at least one actuator designed to activate the contractile structure. Each contractile element (100) is connected to an adjacent contractile element (100), while remaining flexible one with respect to the other.

Abstract: A system for estimating a location of an occluded skeleton, a method for estimating a location of an occluded skeleton and a method for reconstructing an occluded skeleton are provided. The method for estimating a location of an occluded skeleton comprises the following steps: Firstly, a trace of a reference central point of a body is estimated according to a plurality of continuously moving images. Next, a human movement state is estimated according to the trace and a motion information of the continuously moving images free of skeleton occlusion. Then, a possible range of the occluded skeleton for maintaining human balance is calculated according to the human movement state. Afterwards, a current motion level of the occluded skeleton is predicted according to a historic motion information of the occluded skeleton. Lastly, the location of the occluded skeleton is estimated according to the current motion level and the possible range.

Abstract: A clip unit for ligating a biological body includes: a clip body having a pair of arm parts; and a fastening ring arranged in an outside of the clip body, and configured to fasten the arm parts, in which: the fastening ring includes a flap part configured to expand diametrically outward from the fastening ring, and a flap retaining unit configured to retaining an expansion extent of the flap part at a given extent.

Abstract: A clip unit includes: a clip body having a pair of arm parts; and a fastening ring arranged in the outside of the clip body and configured to maintain the arm parts in the closed state, in which the clip body includes a connection base section connecting the base end side of the pair of arm parts, and a connection tail section provided on the connection base section to extend opposite to the arm parts and connected to the front end of a transmission member, and the connection base section has a flat part perpendicular to the axial direction of the fastening ring, and the arm parts and the connection tail section are connected on a side of the flat part.

Abstract: A clip unit used in a ligation device for ligating a biological tissue, includes: arms protruding from a rear end of the clip unit to define a space for accommodating a hook; and engagement claw parts respectively extending from rear ends of the arms toward a front side, in which: when the clip unit and a transmission member are connected, front ends of the engagement claw parts abut against a rear side inclined surface of the hook.

Abstract: In a compression sleeve for the local enclosure of a blood vessel or vein area comprising a retaining structure of a biocompatible material, the retaining structure is a flexible mat consisting of a mesh or net-like structure provided with an arrangement holding the retaining structure in a vein enclosing position.

Abstract: Implantable devices for placement at a cavity or opening such as an aneurysm are disclosed. The implantable devices, in a deployed condition, have a generally inverted U-shaped profile with a curved or angled framework support structure sized and configured for placement in proximity to tissue surrounding the opening and anchoring legs extending proximally from the framework structure sized and configured to contact the wall of a neighboring lumen at opposed locations. Occlusive and semi-occlusive membranes may be associated with the framework support structure and deployed over the opening to provide exclusion of the opening and flow diversion. Proximal anchoring segments providing additional lumen wall surface area contact for the implantable device following deployment may be incorporated.

Abstract: Systems and methods are described for the use of floating magnetic elements in medical implants. The magnetic elements within the medical implant are allowed to rotate freely to align with a strong external magnetic field, such as that of an MRI scanner, and align to attract each other during the normal functioning of the medical implant in the absence of a strong external magnetic field.