Abstract: Systems and method relate to administering phototherapy. A device includes a hollow structure having at least a first open end. The hollow structure includes a rotatable member, one or more coherent light generators, and, for each coherent light generator, one or more lenses or mirrors optically connected to the coherent light generator and configured to alter at least one aspect of a beam of coherent light. The device further includes a processing circuit including a processor and a memory storing instructions. The instructions, when executed by the processor, cause the processor to accept an input from an operator and generate one or more beams of coherent light according to a plurality of settings configured to produce a therapeutic effect at a targeted treatment site. Additionally, the rotatable member is configured to be rotated to direct the one or more beams of coherent light to the targeted treatment site.

Abstract: Described herein are shock wave devices and methods for the treatment of calcified heart valves. One variation of a shock wave device may comprise an elongated flexible tube carried by a sheath. The tube may have a fluid input end, which may be located near a proximal end of the sheath. The tube may include a loop portion. The loop portion may be configured to be at least partially accommodated within a cusp of the heart valve. The tube may be fillable with a conductive fluid. In some variations, the shock wave device may include an array of electrode pairs associated with a plurality of wires positioned within the loop portion of a tube. The electrode pairs may be electrically connectable to a voltage source and configured to generate shock waves in the conductive fluid in response to voltage pulses.

Abstract: A laser beam treatment system that delivers laser beam pulses to a dental treatment area according to a particular pattern is described. In various instances, the spacing of the pattern (e.g., locations at which pulses are delivered and the distances therebetween) and/or the timing of the pattern (e.g., amount of time between the delivery of pulses to a first location and a later location that abuts the first location) can have a demonstrable effect on ablation performance. The effects can include, for example: improved ablation efficiency, improved surface smoothness, improved material removal rate, and/or the absence of melt, carbonization or other negative surface features.

Abstract: A medical device inspection scope may include a cylindrical outer layer having a diameter of less than 2 millimeters or even less than 1 millimeter, a cylindrical inner layer disposed concentrically within the outer layer, a circumferential space between the outer layer and the inner layer, and an inner lumen formed by the inner layer. The scope also includes multiple light transmitting fibers disposed in the circumferential space and a camera module disposed in the inner lumen. The light fibers may be designed to transmit illumination light and ultraviolet light. The scope may also optionally include a stiffening member.

Abstract: Embodiments of a method for removing a tattoo through patterned trans-epidermal pigment release includes determining first treatment area of skin of a patient through a primary template including primary apertures, marking the first treatment area of skin of the patient along borders of the primary apertures to outline a grid of primary tegulae, and delivering a tattoo removal fluid to the marked first exposed skin. In an alternate embodiment, a template, which may be adhered to the skin, is used during a disruption process to create a structured, patterned procedure to remove skin irregularities. The template has a plurality of needle apertures, an adhesive layer, and a release liner. The release liner may be removed, exposing the adhesive layer, so that the template, with the plurality of needle apertures, may be positioned over the skin irregularity.

Abstract: Provided herein are systems, devices and methods for the treatment of fungus. In particular, provided herein are systems, devices and methods employing energy to nail and tissue structures to treat fungal infection.

Abstract: A light delivery device for delivering light therapy includes a light source configured to emit light, one or more first piercing members extending from a distal surface of the light delivery device, the one or more first piercing members being light-transmissive and being configured to be inserted into a subdermal or intradermal portion of the skin of the subject as the distal surface is placed against the skin of the subject. The one or more first piercing members are configured to, when inserted into the skin of the subject, deliver the light to the subdermal or intradermal portion of the skin of the subject.

Abstract: An arthroscopic device is used with a hand piece having a motor drive with a rotating drive shaft. An elongate probe extending along a longitudinal axis and includes a proximal hub on a proximal end. The proximal hub detachably couples to the hand piece, and an operable-closeable jaw structure is disposed on a distal end of the elongate probe. A conversion mechanism carried by the hub converts a rotational motion of the motor drive shaft to a longitudinal motion of an actuator member. The actuator member drives the jaw structure between jaw-open and jaw-closed positions to resect bone and other hard tissues.

Abstract: The amount of energy to provide optical breakdown can be determined based on mapped optical breakdown thresholds of the treatment volume, and the laser energy can be adjusted in response to the mapped breakdown thresholds. The mapping of threshold energies can be combined with depth and lateral calibration in order to determine the location of optical breakdown along the laser beam path for an amount of energy determined based on the mapping. The mapping can be used with look up tables to determine mapped locations from one reference system to another reference system.

Abstract: A therapy device comprises a shaft extending between proximal and distal portions, a surgical instrument located at the distal portion, a handpiece located at the proximal portion, a treatment end located at the distal end of the surgical instrument that can apply photodynamic therapy (PDT). The treatment end includes an applicator to apply a photosensitizer to a surface of a target tissue and a light emitter that can emit generated phototherapeutic light to activate the photosensitizer to ablate target tissue. A method for providing PDT to the target tissue includes inserting the therapy device into the patent, applying the photosensitizer and phototherapeutic light to a surface of the target tissue, and removing the device from the patient.

Abstract: An optical fiber device may include an optical waveguide to guide a laser output from a first end of the optical waveguide to a second end of the optical waveguide. The optical fiber device may include a fiber telescope optically coupled to the second end of the optical waveguide to modify the laser output. The fiber telescope may include a first graded-index optical element, a first facet of the first graded-index optical element being fused to the second end of the optical waveguide; and a second graded-index optical element, a first facet of the second graded-index optical element being fused to a second facet of the first graded-index optical element.

Abstract: A surgical instrument includes an anvil and an elongate channel. The elongate channel includes a plurality of first electrical contacts and a plurality of electrical connectors comprising a plurality of second electrical contacts, wherein the electrical connectors are spring-biased such that a gap is maintained between the first electrical contacts and the second electrical contacts. The surgical instrument further includes a staple cartridge releasably attachable to the elongate channel, wherein the staple cartridge has a cartridge body comprising a plurality of staple cavities, a plurality of staples deployable from the staple cavities into the tissue, and a plurality of third electrical contacts, wherein the attachment of the staple cartridge to the elongate channel moves the electrical connectors causing the second electrical contacts to bridge the gap and become electrically coupled to the first electrical contacts.

Abstract: Embodiments of the invention include a compact, lightweight, hand-held laser treatment device that combines the emissions of two separate laser energy sources into a common optical pathway for improved therapeutic effect. In some embodiments, the device includes a housing having separate first and second laser sources disposed within the interior thereof. In some embodiments, the laser energy emissions from the two internal laser sources can be individually or concurrently transmitted to a delivery tip of the device via a laser transmission path also defined within the interior of the housing. In some embodiments, the structural and functional features of the first and second laser sources, in concert with the unique architecture of the laser transmission path, can be configured to provide efficacy and efficiency in the operation of the device within the spatial constraints of the lightweight, hand-held housing thereof.

Abstract: A method and apparatus for performing ophthalmic laser surgery using a pulsed laser beam is provided. The method includes establishing an initial cutting pattern comprising a plurality of original photodisruption points, establishing an enhanced cutting pattern comprising a plurality of enhanced photodisruption points selected to decrease potential adverse effects due to patient movement and having increased density over a fixed area as compared with the plurality of original photodisruption points, and performing an ocular surgical procedure according to the enhanced cutting pattern Enhanced cutting patterns may include circular cuts around the periphery of a capsule, vertical side cuts for lens fragmentation, raster lamellar cuts, and grid lamellar cuts. Each photodisruption point in the initial cutting pattern and the enhanced cutting pattern comprises a laser target point.

Abstract: A vapor delivery system and method is provided that includes a number of features. In one embodiment, a method comprises inserting a vapor delivery needle into tissue of a patient, activating a flow of vapor from a vapor generator through vapor delivery ports of the vapor delivery needle to cause condensed liquid to exit vapor delivery ports of the vapor delivery needle, generating vapor in the vapor generator, delivering a dose of vapor through the vapor delivery ports of the vapor delivery needle into the tissue, and after the dose of vapor is delivered, re-activating the flow of vapor from the vapor generator through the vapor delivery ports of the vapor delivery needle to prevent a vacuum from forming in the vapor delivery needle. Vapor therapy systems are also provided.

Abstract: An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

Abstract: The present disclosure is directed to a medical device assembly. The medical device assembly described herein may include a medical device and a control unit. The medical device may include an imaging apparatus, an electrical wire coupled to the imaging apparatus, an illumination device, an illumination connector coupled to the illumination device, and a connector coupled to the electrical wire and the illumination connector. The control unit may include an electrical interface, a light source, and a port, wherein the port is configured to receive the connector to operatively couple the electrical wire to the electrical interface, and to operatively couple the illumination connector to the light source, the connector being removably attachable to the port.

Abstract: A system is configured to bring about anastomosis between two lumens in a patient or between two sections of a single lumen in a patient. The anastomosis system includes a first tissue-compressing element, a second tissue-compressing element, and an energy source. The energy source can be a thermal energy source or laser energy source. Tissue is interposed between the elements. Magnetic material incorporated into the tissue-compressing elements facilitates the alignment of the elements as well as compression of the interposed tissue. The energy source can deliver energy to tissue. This delivery of energy can cause local changes to the tissue that can help maintain positional stability of the implants, can bring about immediate patency of the anastomosis and can otherwise facilitate achieving desired outcomes for the patient.

Abstract: Multi-fiber laser probes utilize relative motion of fibers and other laser probe elements to preserve small-gauge compatibility while providing for multi-spot beam deliver, or to provide for the selectively delivery of single-spot or multi-spot beam patterns. An example probe includes fibers having distal ends that are movable as a group onto a distal ramp element affixed to a distal end of a cannula, so that the distal ends of the fibers can be moved between a retracted position, in which the distal ends of the fibers are within the cannula or ramp element, and an extended position, in which distal ends of the fibers are guided by grooves or channels of the ramp so as to extend at least partially through external openings in the distal end of the laser probe and so as to be pointed angularly away from a longitudinal axis of the cannula.

Abstract: Systems and methods for etching complex patterns on an interior surface of a hollow object are disclosed. A method generally includes positioning a laser system within the hollow object with a focal point of the laser focused on the interior surface, and operating the laser system to form the complex pattern on the interior surface. Motion of the laser system and the hollow object is controlled by a motion control system configured to provide rotation and/or translation about a longitudinal axis of one or both of the hollow object and the laser system based on the complex pattern, and change a positional relationship between a reflector and a focusing lens of the laser system to accommodate a change in distance between the reflector and the interior surface of the hollow object.

Abstract: A side-firing laser system with a standoff catheter includes an optical fiber configured to emit therapeutic laser radiation in a direction generally transverse to an axis of the fiber; and a catheter through which the optical fiber is inserted during a surgical procedure. The catheter includes a transparent end section through which the therapeutic laser radiation passes to vaporize tissue outside the catheter, an open distal end to permit exit of irrigation fluid from the catheter, and an opening in a side of the end section, the opening having dimensions that are approximately equal to or less than cross-sectional dimensions of the therapeutic laser radiation. When the fiber is moved to a position at which the therapeutic laser radiation passes through the opening, the laser radiation causes coagulation or vaporization of tissues.

Abstract: An end effector assembly for an optical surgical instrument includes a jaw member and a plurality of optical elements positioned within a cavity of the jaw member. The jaw member has a tissue contacting surface. The jaw member has a proximal portion that is configured to secure a fiber optic cable thereto such that a distal end of the fiber optical cable extends into the cavity. The plurality of optical elements are arranged in a staircase-like manner that rises towards the tissue contacting surface as the plurality of optical elements extends distally within the cavity. The plurality of optical elements is configured to direct a beam of light exiting the fiber optic cable towards the tissue contacting surface.

Abstract: A method for controlling screen rotation of an electronic reading device that includes processing circuitry, an accelerometer, and a display screen. The method including: receiving, by the processing circuitry, a request to access a menu for initiation of a screen-rotation lock function for the electronic reading device; displaying, on the display screen, the menu for the initiation of the screen-rotation lock function; receiving, by the processing circuitry, a selection of one particular screen orientation for the display screen from among a plurality of screen orientations; rotating, the electronic reading device, 90 degrees; detecting, by the accelerometer, the 90 degree rotation; and maintaining a screen that is displayed on the display screen in the selected one particular screen orientation.

Abstract: Embodiments of this invention generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incision. In an embodiment, an ophthalmic surgical laser system comprises a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, an XY-scan device to deflect the pulsed laser beam, a Z-scan device to modify a depth of a focus of the pulsed laser beam, and a controller configured to form a top lenticular incision and a bottom lenticular incision of a lens in the subject's eye, where each of the top and bottom lenticular incision includes a center concave portion and an edge transition portion that has a smooth convex shape and is smoothly joined to the center concave portion.

Abstract: A system is provided for treating a skin surface of a user, comprising: at least one light emitting source configured to focus light on a specified skin region of the user, the light being configured to treat a skin condition of the user; and a controller configured to control emission of the light onto the specified skin region of the user.

Abstract: A medical apparatus can include an instrument comprising a shaft and a jaw assembly coupled to an end of the shaft; an image capture device; and a controller operably coupled to the image capture device to receive image data from the image capture device. The image data is from images of material gripped between jaw members of the jaw assembly and captured by the image capture device, with the controller programmed to process the received image data using at least one of optical flow and digital image correlation. A medical apparatus can include an instrument comprising a shaft, and a jaw assembly coupled to an end of the shaft, the jaw assembly comprising a pair of jaw members having opposing surfaces configured to grasp material between the opposing surfaces, wherein at least a portion of the opposing surface of a first jaw member of the pair of jaw members is transparent.

Abstract: A movement amplifying actuation device may include two piezoelectric beams, one beam being attached at a fixed point, and a hinge connecting a first beam and a second beam between them. Each hinge may include a first flexible portion connected to the first beam, a second flexible portion connected to the second beam, a first rigid portion connecting the first and second flexible portions, a second rigid portion capable of being positioned against a fixed point, and a third flexible portion connecting the second beam to the second rigid portion at a pivot point of the second beam such that the assembly formed by the second rigid portion and the second beam forms a lever around the pivot point. The flexible and rigid portions may form a single piece.

Abstract: A plastic optical fiber for a medical device lighting decreases the cost of a lens and simplify the design of a lighting apparatus, wherein the plastic optical fiber for a medical device includes a core composed of a (co)polymer containing methyl methacrylate as a main component and is characterized by including a cladding material composed of a copolymer having a fluorine weight composition ratio of 60 to 74%, and by having a theoretical numerical aperture, NA, of 0.48 to 0.65 and, thus, the plastic optical fiber has a high numerical aperture and also has excellent translucency and flexibility.

Abstract: A system for treatment of wounds consists of a treatment housing, a fluid delivery mechanism for supplying debridement fluids to the wound treatment area, an evacuation mechanism for evacuation of debris from the treatment chamber. A handheld device is connected to the treatment housing, wherein its interior accommodates a laser source, a scanning device, an image recording device and at least one sensor/detector, a control unit having a microprocessor for controlling operation of the system. The sensor detects concentration of various substances in the wound, and the microprocessor analyzes data obtained by the sensor and generates signals to adjust parameters of the laser, the liquid dispensing nozzles and the suction outlet to optimize removal of necrotic tissue so as to ultimately to promote wound healing.

Abstract: Apparatus and methods for deactivating pulmonary nerves extending along the main bronchi of a mammalian subject to reduce ARDS effects by advancing an ultrasound transducer into the right and subsequently left main bronchus. The ultrasound transducer emits circumferential ultrasound so as to heat a circumferential tissue volume encompassing the right and left main bronchus. The energy of <10 W acoustic for <5 sec will not be sufficient to cause tissue necrosis but sufficient to inactivate nerve conduction. This treatment can be performed without locating or focusing on individual pulmonary nerves.

Abstract: This present invention proposes new methods of designing single-use endoscopes with built-in optical fibers and operating fixtures. As compared to conventional endoscopes, a separate lumen is reserved for integrating a laser fiber along the insertion tube of the proposed endoscope, and an optical fiber placement device (OFPD) is correspondingly added in the endoscope handle for controlling the movement of the laser fiber. By sliding the slider or dialing the wheel of OFPD, a surgeon can conveniently control movement of the laser fiber. By pressing a retractable control stick in the OFPD, the surgeon can either push the laser fiber out from the endoscope's distal-end or pull back the laser fiber, further unlocking or locking the power switch of the laser fiber to avoid mis-operations. All these above operations can be performed by the surgeon's one-hand, including the routine deflections and rotations of the endoscope. Four implementations of the OFPD are introduced in this invention.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: Apparatus and methods for deactivating pulmonary nerves extending along the main bronchi of a mammalian subject to reduce ARDS effects by advancing an ultrasound transducer into the right and subsequently left main bronchus. The ultrasound transducer emits circumferential ultrasound so as to heat a circumferential tissue volume encompassing the right and left main bronchus. The energy of <10 W acoustic for <5 sec will not be sufficient to cause tissue necrosis but sufficient to inactivate nerve conduction. This treatment can be performed without locating or focusing on individual pulmonary nerves.

Abstract: A method for a minimally invasive, cell-selective laser therapy on the eye. The method, based on a short-pulse laser system, allows for different selective types of therapy on the eye. The method is based on a frequency-doubled, continuously working solid-state laser including a pump source and a control unit. The control unit regulates the pump source such that the solid-state laser emits individual pulses with pulse lengths ranging from 50 ns to continuous, wherein pulse lengths ranging from 50 ns to 50 ?s are provided for selective therapies and pulse lengths ranging from 50 ?s to continuous are provided for coagulative or stimulating therapies, in particular in the range from 1 ms to 500 ms. The proposed method enables a selective treatment of melanin-containing cells in the different areas of the eye via the targeted control of the pump source.

Abstract: A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Abstract: Methods and apparatus for the treatment of a body cavity or lumen are described where a heated fluid and/or gas may be introduced through a catheter and into treatment area within the body contained between one or more inflatable/expandable members. The catheter may also have optional pressure sensing elements which may allow for control of the pressure within the treatment zone and also prevent the pressure from exceeding a pressure of the inflatable/expandable members to thereby contain the treatment area between these inflatable/expandable members. Optionally, a chilled or room temperature fluid such as water may then be used to rapidly terminate the treatment session.

Abstract: A method for minimally invasive surgery using therapeutic ultrasound in spine and orthopedic orthopedic procedures. The method includes a minimally invasive access port, a therapeutic ultrasound probe to treat a targeted area through the port, and a protective sheath that enables application of the therapeutic ultrasound without causing unintended tissue damage.

Abstract: The laser lancing device in accordance with an exemplary embodiment includes: a main body; a laser resonator located within the main body and configured to generate a laser and output the laser forwards; a beam barrel located in front of the laser resonator and including at least one lens unit fixed therein; a window barrel located in front of the beam barrel and connected to the main body; a cap part connected to the front of the window barrel and brought into contact with an irradiation target area; a fan unit communicating with the cap part and induce flow of air; and a communication pipe of which one end is connected to the fan unit and the other end is connected to the cap part.

Abstract: A method for laser eye surgery that accommodates patient movement includes: generating a first and a second electromagnetic radiation beam, the second beam configured to modify eye tissue; propagating the first beam to a scanner along a an optical path length that changes in response to eye movement; focusing the first beam to a first focal point within the eye; scanning the first focal point at different locations within the eye; propagating a portion of the first beam reflected from the first focal point location back along the variable optical path to a sensor; generating an intensity signal indicative of the intensity of the portion of the reflected first beam; propagating the second beam to the scanner along the variable optical path; focusing the second beam to a second focal point and scanning the second focal point to create an incision in the cornea of the eye.

Abstract: Dermatological systems and methods for providing a picosecond laser treatment a plurality of treatment wavelengths, at least one of which is provide by an optical parametric oscillator (OPO).

Abstract: There is provided a light treatment device (1). The device (1) comprises a carrier (11) having an opening (5) for positioning over and viewing a treatment area and a light emitter (6) for providing treatment light to the treatment area. There is also provided an attachment (3) for attaching the carrier to a patient. The device is useful as the opening can be positioned over an area where light therapy is desired, whilst viewing the area, and then held in position with the attachment. Light therapy can then be administered to the area and treatment of areas where light therapy is not desired can be avoided.

Abstract: [Object] To provide an ablation system capable of suppressing heat damages to the lumen intima. [Solution] An ablation system 10 has an ablation device 11 in which a balloon 21 is provided on the distal end side of a shaft 22 and an in-side tube 27 causing a fluid to flow into the balloon 21, the internal space of the shaft 22 causing a fluid to flow out of the balloon 21, and an optical fiber 29 guiding laser light into the balloon 21 are individually provided along the shaft 22, a laser light generating unit 12 emitting laser light to the optical fiber 29, and a fluid returning unit 13 returning a fluid into the internal space of the balloon 21. The ablation device 11 has a reflector 33 reflecting laser light emitted from the optical fiber 29 in the balloon 21, in which the reflector 33 is movable along the axial direction 191 in the balloon 21 and is rotatable in the axial direction 101 as the axis line.

Abstract: A laser treatment apparatus includes a primary handset and an auxiliary handset; the primary handset is connectable to the auxiliary handset; the primary handset has a laser source with a primary heat exchanger, and a main cooling circuit to provide cooling fluid to the primary heat exchanger to cool the laser source; the cooling circuit has a circuit connection for engagement with the auxiliary handset. The circuit connection comprises one or more fluid connectors for connection to an auxiliary cooling circuit within the auxiliary handset and the cooling circuit within the auxiliary handset includes a secondary heat exchanger. An electro-mechanical mechanism within the primary handset switches from a first position so that cooling fluid flows in the main cooling circuit within the primary handset when no auxiliary handset is attached and in a second position diverts flow of the cooling fluid to the heat exchanger in the auxiliary handset when the auxiliary handset is connected to the primary handset.

Abstract: A terminus for a fiber optic cable includes a ferrule. In one embodiment, an optical fiber of the cable passes through a central bore of the ferrule and is attached to a lens seated in a conical or cylindrical seat formed in an end surface of the ferrule by an epoxy. In a second embodiment, an optical fiber of the cable passes through the central bore of the ferrule. Next, a cap sleeve with a lens therein is slid over and attached to the ferrule such that the lens abuts or is attached to the optical fiber. In either embodiment, an inspection slot may optionally be formed in the ferrule and/or the cap sleeve to allow a technician to inspect the state of the attachment and/or abutment and/or spacing of the optical fiber and the lens.

Abstract: An apparatus for laser assisted eye treatment comprises: a laser device configured to provide focused laser radiation and having an adapter coupling port; an adapter module including first and second sub-modules, the first sub-module configured to detachably couple to the laser device at the adapter coupling port and having a contact surface for an eye, the second sub-module including an eye suction ring portion having a ring axis, wherein the second sub-module delimits at least one suction space, and the adapter module includes a vacuum inlet port in association with each of the at least one suction chamber, wherein the adapter module includes an evacuation path system configured to establish a vacuum communication connection between each of the at least one suction space and the associated vacuum inlet port, wherein the vacuum inlet port is provided at the first sub-module and the evacuation path system extends from the first sub-module to the second sub-module.

Abstract: Methods and systems are provided for determining the location of procedure sites, for example hair implantation sites, the method and systems enabling a natural looking randomness to be maintained to achieve a desired density while avoiding previously created procedure sites and existing features.

Abstract: Providing neuroprotective therapy for glaucoma includes generating a micropulsed laser light beam having parameters and characteristics, including pulse length, power, and duty cycle, selected to create a therapeutic effect with no visible laser lesions or tissue damage to the retina. The laser light beam is applied to retinal and/or foveal tissue of an eye having glaucoma or a risk of glaucoma to create a therapeutic effect to the retinal and/or foveal tissue exposed to the laser light beam without destroying or permanently damaging the retinal and/or foveal tissue and improve function or condition of an optic nerve and/or retinal ganglion cells of the eye.

Abstract: Providing neuroprotective therapy for glaucoma includes generating a micropulsed laser light beam having parameters and characteristics, including pulse length, power, and duty cycle, selected to create a therapeutic effect with no visible laser lesions or tissue damage to the retina. The laser light beam is applied to retinal and/or foveal tissue of an eye having glaucoma or a risk of glaucoma to create a therapeutic effect to the retinal and/or foveal tissue exposed to the laser light beam without destroying or permanently damaging the retinal and/or foveal tissue and improve function or condition of an optic nerve and/or retinal ganglion cells of the eye.

Abstract: A process for performing retinal phototherapy or photostimulation includes generating a laser light that creates a therapeutic effect to retinal and/or foveal tissues exposed to the laser light without destroying or permanently damaging the retinal or foveal tissue. The laser light is applied to a first treatment area of the retina. After a predetermined interval of time, within a single treatment session, the laser light is reapplied to the first treatment area of the retina. During the interval of time between the laser light applications to the first treatment area, the laser light is applied to one or more additional areas of the retina that is spaced apart from the first treatment area and one another. The laser light is repeatedly applied to each of the areas to be treated until a predetermined number of laser light applications to each area to be treated has been achieved.

Abstract: In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.