Abstract: Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.

Abstract: Devices for removing clot material from a blood vessel lumen and associated systems and methods are disclosed herein. A clot retrieving device may include, for example, an elongated shaft, a capture structure having a proximal portion and a distal portion, and a cover having a first portion coupled to the elongated shaft and a second portion extending from the first portion. The cover may have an inverted configuration in which the capture structure is at least partially ensheathed within the first portion of the cover and the second portion of the cover extends distally from the first portion. In the inverted configuration, the second portion may have (a) a first region distal to a distal terminus of the capture structure, the first region tapering radially inwardly in a distal direction, and (b) a second region extending distally and radially outwardly from the first region.

Abstract: Devices, systems, and methods for treating vascular defects are disclosed herein. One aspect of the present technology, for example, includes an occlusive device comprising a mesh having a low-profile state for intravascular delivery to the aneurysm and a deployed state, the mesh comprising a first end portion, a second end portion, and a length extending between the first and second end portions, and a first lateral edge, a second lateral edge, and a width extending between the first and second lateral edges. The mesh may have a predetermined shape in the deployed state in which (a) the mesh is curved along its width, (b) the mesh is curved along its length, and (c) the mesh has an undulating contour across at least a portion of one or both of its length or its width. The mesh is configured to be positioned within the aneurysm in the deployed state such that the mesh extends over the neck of the aneurysm.

Abstract: Described here are systems, devices, and methods for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration. In some instances a delivery device may aid in crimping and/or delivery of the implant.

Abstract: Apparatus and methods for additive manufacturing with variable extruder profiles are described herein. An extruder print head with multiple nozzles placed at different angles allows for additional degrees of freedom to additively manufacture parts with complex shapes. In addition with the use of shape memory alloy materials, the diameter of one or more nozzles can be adjusted during the additive manufacturing process. This allows for independent control of the build resolution and of the build rate.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a first configuration and a second expanded configuration, an occlusive member disposed along at least a portion of an outer surface of the expandable framework and a resilient member coupled to the occlusive member. Further, the resilient member is configured to keep the occlusive member taut against an outer surface of the expandable member in both the first configuration and the second configuration.

Abstract: A filter device insertable into a biological lumen includes a shaft portion and an elastically deformable portion interlocked with the shaft portion, the deformable portion having a plurality of wires braided in a mesh shape. The wires include wires of a first type, each having a diameter d. A sum of d3 of all of the wires is 0.08 to 0.25 mm3.

Abstract: A vascular filter system comprises a vascular filter (1), a clamp device (50), and a delivery catheter (51). The filter (1) comprises filter elements (6). When used without the clamp device (50), the filter elements (6) move from a closed state to an open state upon elapse of a predetermined period of time. In the closed state the filter elements (6) capture thrombus passing through the inferior vena cava (2). The delivery catheter (51) is employed to deliver the clamp device (50) to the filter (1) after the filter (1) has been deployed in the inferior vena cava (2). The clamp device (50) engages with the filter elements (6) of the filter (1) to clamp the filter (1) in the closed state beyond elapse of the predetermined period of time. Because of the presence of the clamp device (50), the filter elements (6) are no longer free to move from the closed state to the open state upon elapse of the predetermined period of time.

Abstract: The invention provides a filter assembly including a string or wire such that a lasso type cincture is effected, said filter being openable and closeable while in deployed within a bodily vessel. A string lengthen or shorting adjustment mechanism, such as a ratchet or reel allows more length of string into the device or alternatively to shorten the length of available string in the system. The described invention, when used to ameliorate venous clots and most arterio-venous dialysis grafts, a filter-tipped aspirator is used downstream from the clot to capture and remove dislocated emboli. A method of using same is disclosed.

Abstract: Provided herein is an occlusion device comprising: (a) a substantially solid marker band having an inner and outer diameter, a proximal end, and a distal end; and (b) a resilient mesh body attached within the marker band, wherein the body is a length y, and wherein the body comprises a bolus of additional resilient mesh material of a length x, wherein y is greater than x, and wherein the body extends distally from the marker band having a first delivery shape and a second expandable deployed shape. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device disclosed herein are also disclosed.

Abstract: A prosthetic heart valve may include a valve portion, a tether connected to the valve portion, and an anchor for connecting the tether to the wall of the heart. The anchor may include a flexible first disc biased toward a first shape that is convex in a first direction and a neck extending from the first disc in a second direction opposite the first direction. The neck has a first end connected to the first disc and a second end. The anchor may further include a flexible second disc connected to the second end of the neck and biased toward a second shape that is convex in the first direction. When deployed, the first and second discs sandwich the wall of the heart.

Abstract: The present invention discloses a steerable guidewire and a method for manufacturing the same, and a steerable catheter and a method for manufacturing the same. According to an aspect of the present invention, a steerable guidewire, which is inserted into a catheter and guides the catheter to a desired blood vessel, may include: a steerable tip part that can be bent in at least two stages due to a stimulus from the outside and that is steered in a predetermined direction; and a non-steerable tip part that is not steerable. The steerable tip part may include: a first steerable tip part having a first length and bent in a first angle with respect to the non-steerable tip part; and a second steerable tip part having one end connected to the first steerable tip part, having a second length, and bent and steered into a second angle with respect to the non-steerable tip part. The first steerable tip part may be positioned farther from the non-steerable tip part than the second steerable tip part.

Abstract: The invention provides a filter assembly including a string or wire such that a lasso type cincture is effected, said filter being openable and closeable while in deployed within a bodily vessel. A string lengthen or shorting adjustment mechanism, such as a ratchet or reel allows more length of string into the device or alternatively to shorten the length of available string in the system. The described invention, when used to ameliorate venous clots and most arterio-venous dialysis grafts, a filter-tipped aspirator is used downstream from the clot to capture and remove dislocated emboli. A method of using same is disclosed.

Abstract: Vaso-occlusive apparatuses, including implants, and methods of using them to treat aneurysms. For example, described herein are expandable vaso-occlusive implants that include one or more soft and expandable braided member coupled to a pushable member such as a coil that maybe inserted and retrieved from within an aneurism using a delivery catheter. In particular, the expandable implants described herein are configured to allow relatively soft and elongate implants to be pushed out of a cannula without binding up within the cannula.

Abstract: Various aspects of the present invention provide an apparatus and a method of removing an orthopedic implant from a patient. In one embodiment, the method includes cycling the temperature of at least a portion of the orthopedic implant between a first temperature and a second temperature that differs from the first temperature. In one embodiment, the first temperature is above 0° C. and the second temperature is below 0° C. The temperature cycling causes a thermal expansion differential between at least a portion of the orthopedic implant and material in a region contacting the orthopedic implant. In one embodiment, the thermal expansion differential is of an extent sufficient to cause physical separation of at least a portion of the surface of the orthopedic implant from material contacting the surface of the orthopedic implant.

Abstract: Multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a multi-filter blood filtering system captures and removes particulates dislodge or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a dual filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

Abstract: There is provided a laminate membrane for an implant, comprising: an inner layer having an inner layer thickness; a first covering layer disposed on one side of the inner layer, the first covering layer having a first covering layer thickness; and a second covering layer disposed on another side of the inner layer, the second covering layer having a second covering layer thickness.

Abstract: A deployable occlusion device for filling an aneurysm. The occlusion device includes a support structure, for example a wire or otherwise elongate structure. The occlusion device also includes a mesh component having a porosity. The mesh component has a first end portion and a second end portion. The first end portion of the mesh component is attached to the support structure and the second end portion of the mesh component is a free end. The mesh component extends from the support structure.

Abstract: A vessel occluder used to occlude blood flow within the vasculature is described. The vessel occluder can include an expandable mesh portion having a flexible membrane that expands within a cavity of the expandable mesh portion. When expanded, the flexible membrane blocks blood passage through the mesh portion.

Abstract: A balloon catheter including a heating element disposed about a portion of an outer surface of a catheter shaft; a balloon mounted about the outer surface of the catheter shaft to coincide with the heating element; and thermally expandable material disposed inside the mounted balloon. The balloon catheter eliminating the need for pressurized liquid inflation media to be dispensed into/expelled from the balloon in order to inflate/deflate, respectively, the balloon.

Abstract: Rolling tractor tube mechanical thrombectomy apparatuses that may be deployed from out of a catheter in situ are described herein. These apparatuses may be delivered out of a catheter from a collapsed delivery configuration within the catheter to a deployed configuration out of the catheter, in which the same catheter is re-inserted between a tubular tractor and an elongate puller. In particular, any of these methods and apparatuses may be adapted to work with a tractor tube having an open end that is biased open, including using an annular bias.

Abstract: In vivo and ex vivo positionable filtration devices are provided that are functionalized to bind one or more therapeutic agents in blood flowing in a blood vessel.

Abstract: A removable blood clot filter includes a number of locator members and anchor members disposed radially and extending angularly downward from a hub. The locator members include a number of linear portions having distinct axes configured to place a tip portion approximately parallel to the walls of a blood vessel when implanted to apply sufficient force to the vessel walls to position the filter near the vessel centerline. The anchor members each include a hook configured to penetrate the vessel wall to prevent longitudinal movement due to blood flow. The hooks may have a cross section sized to allow for a larger radius of curvature under strain so that the filter can be removed without damaging the vessel wall.

Abstract: An accessory device may be used in combination with a thrombectomy catheter. The accessory device may be configured to deflect a distal portion of the thrombectomy catheter and/or disrupt a lesion in a vessel.

Abstract: A catheter device for transporting an implant to a target location in a body lumen and also for releasing the implant at the target location. The device includes an outer shaft configured to transport the implant to the target location, and an implant capsule configured to receive the implant. The implant capsule has a tubular capsule core, which surrounds the implant prior to the release. The capsule core, at a proximal end of the capsule core, has a plurality of tabs for fixing the capsule core to the outer shaft, which tabs protrude from a tubular portion of the capsule core along an axial direction of the capsule core.

Abstract: A left atrial appendage occluder comprises an elastic closure disc, and a supporting structure connecting with the closure disc and being located on one side of the closure disc, with the supporting structure comprising a central end connecting with the closure disc and a plurality of interconnected and bent struts, wherein at least one anchoring thorn is set near the end of at least one strut with the anchoring thorn toward the closure disc. The left atrial appendage occluder has a stable structure, a good positioning and sealing effect on the cavity wall in the left atrial appendage, and it is easy to position repeatedly; it can also be recycled before separating from a conveyor. When in surgical operation, the left atrial appendage occluder can select the position area based on the actual shape and size of the patient's left atrial appendage, so the surgical risk is lowered.

Abstract: A guide extension catheter includes a push member and a distal shaft coupled to and extending distally from the push member. The distal shaft includes a shaft wall and a passageway. The shaft wall includes a helically-shaped proximal end and a distal end. The helically-shaped proximal end coils helically about a first central longitudinal axis of the passageway of the distal shaft. The helically-shaped proximal end of the shaft wall defines a helically-shaped entry port of the distal shaft. The distal shaft may include a helically-shaped collar coupled to the helically-shaped proximal end of the distal shaft, the collar defining the helically-shaped entry port of the distal shaft.

Abstract: A device for treating an aneurysm with a braided implant can include a delivery tube having a spiral groove on an outer surface of the delivery tube and a braided implant having a spiral segment. The spiral segment can engage the spiral groove as the braided implant is delivered to an aneurysm treatment site. At the treatment site, the braided implant can be implanted, and the delivery tube can be rotated to disengage the spiral segment from the spiral groove. Once released, the spiral segment can reshape to occlude the neck of the aneurysm.

Abstract: A balloon catheter includes a balloon coupled to a shaft. The shaft includes a proximal perfusion portion disposed proximal of the balloon and a distal perfusion portion disposed distal of the balloon. The proximal and distal perfusion portions each are formed by a respective plurality of wire members woven together to form a respective proximal and distal braided shafts. The plurality of wire members are woven together such that a plurality of perfusion openings are formed between the wire members. The plurality of perfusion openings extend from an outer surface of the respective proximal or distal braided shaft to a lumen of the respective proximal or distal braided shaft. A perfusion lumen extends between the proximal perfusion portion and the distal perfusion portion.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework including a body portion and a disk portion, wherein the expandable framework is configured to shift between a collapsed configuration and an expanded configuration, and an occlusive disk element disposed within the disk portion. The disk portion may include a first disk portion integrally formed with the body portion, and a second disk portion movably attached to the first disk portion by at least one hinge member.

Abstract: Embolic protection device for insertion into an aortic arch, with a filter unit, a frame and a feed unit, wherein the filter unit is arranged at the frame and the frame provides a proximal area having a proximal shape, which is arranged in an inner area of the frame and is connected to the feed unit, wherein the proximal shape has a first part and a second part, wherein the second part is formed at one end of the first part.

Abstract: Devices, methods, and systems for closure device for a left atrial appendage and, in particular, to a closure device that includes an anchor element and a disc element that are each individually chosen based on the anatomy of the patient's left atrial appendage and assembled before implantation. In one embodiment, a medical device comprises: an anchor element, the anchor element including a first connection element; and a disc element, the disc element including a second connection element pivotably coupled to the first connection element, the anchor element being sized to be received and retained within a left atrial appendage and the disc element being sized to completely cover an opening of the left atrial appendage.

Abstract: A catheter system that is actuatable to a deployed state and includes a catheter body and a dilator positioned at least partially within the lumen of the catheter. A distal end of the dilator can be releasably connected to a distal tip of the catheter body. The dilator can be retractable to expand and invert the distal tip and form a funnel shape in the deployed state.

Abstract: A blood filter delivery system for delivering a filter into a vein includes an introducer and a push rod with a spline member disposed along the push rod. The spline member has a main body, and first and second boss portions spaced apart along the longitudinal axis to provide a gap for retaining anchor member of the filter during delivery via the introducer.

Abstract: A ventricular partitioning device for isolating damaged tissue within a ventricle of the heart is disclosed. The ventricular partitioning device includes a disk-shaped portion configured to isolate a portion of a ventricular wall to facilitate remodeling of the ventricular wall. The device further includes an anchor configured to secure the device to the ventricular wall.

Abstract: In some examples, a capture assembly configured to remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system, includes a body configured to receive the material of interest. The body can be configured to axially lengthen and shorten.

Abstract: Devices and methods for increasing or restoring a flow in a body lumen. The devices and the methods may treat conditions like stroke by removing a clot from a blood vessel and/or reopen the vessel. The device may include a plurality of engaging elements, a central wire, and proximal control element. The device may include a linking structure between engaging elements. The linking structure may include segments configured to respond differently upon the application of longitudinal loads. The positions of the engaging elements and the distance therebetween can be adjusted simultaneously or sequentially to promote the engagement of the clot or occlusion. The device may include be configured to inhibit or prevent the proximal engaging element from being pulled back into a microcatheter when pulling the central wire to pull the distal engaging element proximally and/or during retraction of the device holding a clot.

Abstract: A medical device may include a handle assembly having an actuator and a sheath. The sheath may extend between a proximal end and a distal end. The proximal end of the sheath may be coupled with the actuator. The medical device may further include an end-effector moveable relative to the sheath between an extended configuration and a retracted configuration. The end-effector may include a plurality of expandable legs. Each of the plurality of expandable legs may include a plurality of first indicia and a plurality of second indicia. A color of each of the first plurality of indicia may be different than a color of each of the second plurality of indicia.

Abstract: An in-vivo indwelling instrument in which a stretch resistant member or a resin tip at a distal end part of a coil does not easily stray from the coil, a delivering system for the in-vivo indwelling instrument, and a method for producing the in-vivo indwelling instrument is disclosed. An in-vivo indwelling instrument includes: a coil that is formed by winding a wire; a resin tip connected to a distal end part of the coil; and a stretch resistant member that is provided in a lumen of the coil and is connected to the resin tip. The coil includes a gap portion, and a part of the resin tip exists in the gap portion.

Abstract: An embolisation device (10) for promoting clot formation in a bodily lumen (L) and having a collapsed delivery configuration for delivery of the embolisation device (10) into, and retrieval of the embolisation device (10) from, the bodily lumen (L) and an expanded deployed configuration for anchoring the embolisation device (10) in the bodily lumen (L). The embolisation device (10) comprises a tubular cage (20) having a collapsed delivery configuration and an expanded deployed configuration. The embolisation device further comprises an embolisation member (30) disposed in the tubular cage (20), the embolisation member (30) comprising a stem (31) and a plurality of flexible bristles (32) extending outwardly from the stem, the plurality of flexible bristles having a collapsed delivery configuration and an expanded deployed configuration.

Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A delivery system for such treatment can include an occlusive member configured to be positioned within an aneurysm sac and having a proximal hub. An elongate tubular member has an engagement member removably coupled to the proximal hub, for example via threaded engagement or an interference fit via one or more engagement members. A conduit extending within or adjacent to the elongated member is configured to receive an embolic element therethrough for delivery to the aneurysm sac.

Abstract: A tissue anchor is provided that includes a head connected to a shaft, and a tissue-coupling element extending from the shaft. The shaft includes a seal that is configured to form a blood-tight seal between the shaft and a heart wall, and to promote hemostasis. When the tissue anchor is unconstrained, the head is coaxial with an axis of the shaft, and the tissue-coupling element is generally orthogonal to the axis and is shaped such that if the tissue-coupling element were to be projected onto a plane that is perpendicular to the axis, at least 80% of an area of a projection of the tissue-coupling element on the plane would fall within a first angle of 180 degrees in the plane having a vertex at the axis. Other embodiments are also described.

Abstract: A hand piece for handling an optical fiber during a laser-surgical intervention comprises a handle body elongated along a main axis and having a through hole extending along the main axis. A guide tube having a tube lumen aligned and communicating with the through hole is attached to the handle body. A fixing device is provided in the handle body for fixing the optical fiber extending through the through hole and the tube lumen in direction of the main axis. The guide tube is made of a shaped memory alloy, which has a transition temperature between 50° C. and 120° C., and which has a straight base shape. Below the transition temperature, the guide tube is bendable by plastic deformation out of the straight base shape into a curved shape, and, when heated up above the transition temperature, the guide tube returns to its straight base shape.

Abstract: A tissue anchor is provided for delivery by a deployment tool in a constrained state, the tissue anchor including a shaft; a tissue-coupling element, which includes a wire including a shape-memory alloy; and a flexible elongate tension member, which is distinct from the wire. The flexible elongate tension member includes a distal portion that is fixed to a site on the wire such that, when the tissue anchor is not constrained by the deployment tool, the flexible elongate tension member applies, to the tissue-coupling element, tension that constrains lateral expansion of the tissue-coupling element away from a central longitudinal axis of the shaft, by preventing the tissue-coupling element from automatically assuming a predetermined shape provided by the shape-memory alloy of the wire. Other embodiments are also described.

Abstract: A clot retrieval device comprising an elongate shaft having a proximal end and a distal end and a clot retrieval element at the distal end of the elongate shaft. A proximal end of the elongate shaft of the clot retrieval device is adapted for retraction of a first catheter over the clot retrieval device elongate shaft. A second catheter is advanced to or adjacent to the distal end of the clot retrieval device shaft to enable enhanced aspiration adjacent to the clot retrieval element.

Abstract: An intravascular device delivery system includes a distal end cap to connect an elongated member of the intravascular device delivery system to an intravascular device. The distal end cap includes at least one connection member radially movable relative to the distal end cap that is configured to engage with a complimentary recess in the intravascular device.

Abstract: A mechanical thrombectomy device, and methods of manufacturing and using the mechanical thrombectomy device, are described. The mechanical thrombectomy device includes several clot arrestors independently mounted on a support wire. The clot arrestors have expandable frames that are eccentrically supported on the support wire. The independently and eccentrically mounted clot arrestors are arranged to allow a clot to pass into, and be captured by, one of the expandable frames. Furthermore, the independently and eccentrically mounted clot arrestors deform independently of one another such that retraction of the mechanical thrombectomy device through tortuous vasculature can stretch one clot arrestor without stretching another one of the clot arrestors to allow the clot to be retained by the unstretched clot arrestors. Other embodiments are also described and claimed.

Abstract: Disclosed herein is a method for occluding a cerebral aneurysm which includes: delivering a flexible implant in a compressed first configuration to a cerebral aneurysm through a catheter; inserting the flexible implant into the aneurysm sac wherein the flexible implant self-expands to a second configuration; and then delivering embolic members and/or embolic material into the flexible implant to expand further the flexible implant into a third configuration which conforms to the walls of even an irregularly-shaped aneurysm sac.

Abstract: A stent system according to the present invention is for use in retrieving a blood clot from the brain region and includes a wire; a first stent connected to a distal portion of the wire; a first outer sheath that covers and is fixed to a portion of the wire proximal to the first stent; and a second stent disposed on a portion of the wire proximal to the first stent, in which the second stent is configured to be movable toward or away from the first stent.

Abstract: Methods and apparatuses for removing material (e.g., clot) from within a body, including inverting thrombectomy apparatuses. These methods and apparatuses may include methods and apparatuses for reusing portion of the devices, method and apparatuses for loading and reloading the inverting thrombectomy apparatuses, and methods and apparatuses for improving and enhancing the ability of the inverting thrombectomy apparatuses to remove clot. In particular, described herein are expandable scraper devices that may be used in conjunction with the inverting thrombectomy apparatuses descried herein, or on their own.