Internal Application Patents (Class 606/21)
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Patent number: 11633228Abstract: A method includes receiving position signals that are indicative of positions of multiple electrodes disposed on an expandable balloon that is fitted at a distal end of a shaft for engaging a lumen of an organ to occlude the lumen. Based on the received position signals, a change is calculated in one or more dimensions of the balloon between (i) a first configuration in which the balloon is inflated but not engaged in the lumen, and (ii) a second configuration in which the balloon is inflated and engaged in the lumen. Using the calculated change, a degree is estimated to which the balloon occludes the lumen. The estimated degree of occlusion is presented to a user.Type: GrantFiled: October 4, 2019Date of Patent: April 25, 2023Assignee: Biosense Webster (Israel) Ltd.Inventors: Eid Adawi, Zvi Dekel
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Patent number: 11612426Abstract: Provided herein are new compositions, methods, and devices to treat cancer through a combination of immunologic chemotherapeutic agents and ablation techniques. These compositions can include immune checkpoint inhibitors, cytokines and nucleic acid drugs that aid in eliciting an immune response to treat the tumor. The administration of these compositions in addition to various ablating techniques provides a presentation of the cancer cell antigens to the immune system and the immunologic targeting of the cancer.Type: GrantFiled: January 13, 2017Date of Patent: March 28, 2023Assignee: ImmunSys, Inc.Inventors: Gary Onik, James A. Miessau, DG Bostwick
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Patent number: 11583329Abstract: A cryosurgical instrument includes a feed line for conveying fluid into an expansion chamber. The feed line has a capillary line section that terminates in the expansion chamber and forms an aperture for the fluid to undergo the Joule-Thomson effect. The flow cross-section of the feed line decreases in at least one transition section of the feed line in the form of a funnel. Following each transition section there preferably follows a step section, in which latter section the flow cross-section is preferably largely constant. The last step section is preferably formed by the capillary line section. Due to the acceleration of the fluid in the transition sections and the abating of pressure fluctuations in the capillary tube section and, optionally in the additional step sections, the expansion range in the expansion chamber is increased, without impeding the backflow of the expanded gas out of the expansion chamber.Type: GrantFiled: August 1, 2018Date of Patent: February 21, 2023Assignee: Erbe Elektromedizin GmbHInventors: Achim Brodbeck, Joerg Kronenthaler, Marcus Adler, Hanna Andel, Klaus Fischer
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Patent number: 11564725Abstract: An ablation apparatus for creating a lesion in target tissue, the ablation apparatus having an ablation shaft including a handle, a first portion, an ablation portion, distal tip, at least one ablation energy delivery lumen, at least one ablation energy return lumen, and a stylet lumen that extends substantially along a length of the ablation shaft from the handle to at least the ablation portion. The ablation apparatus also includes a stylet that is capable of being inserted into the stylet lumen where the stylet is made of a shape-memory material.Type: GrantFiled: September 5, 2018Date of Patent: January 31, 2023Assignee: Adagio Medical, Inc.Inventors: Alexei Babkin, Pedram Nourian, Meital Mazor, Faysal S. Ahmed, David Cabrita
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Patent number: 11510576Abstract: A device, system, and method for treating an area of tissue and evaluating lesion formation and quality. The system may include a medical device having a plurality of mapping electrodes on a treatment element, the plurality of mapping electrodes being configured to record from the area of tissue at least one of unipolar impedance measurements, bipolar impedance measurements, local electrical activity, and pace threshold measurements before, during, and after circulation of the cryogenic fluid within the treatment element. These measurements may be transmitted to a control unit having processing circuitry configured to compare pre-treatment measurements, in-treatment measurements, and/or post-treatment measurements to each other and/or to threshold values to determine occlusion and/or lesion quality, such as lesion transmurality.Type: GrantFiled: April 27, 2017Date of Patent: November 29, 2022Assignee: Medtronic CryoCath LPInventor: Boaz Avitall
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Patent number: 11497544Abstract: Provided herein are new compositions, methods, and devices to treat cancer through a combination of immunologic chemotherapeutic agents and ablation techniques. These compositions can include immune checkpoint inhibitors, cytokines and nucleic acid drugs that aid in eliciting an immune response to treat the tumor. The administration of these compositions in addition to various ablating techniques provides a presentation of the cancer cell antigens to the immune system and the immunologic targeting of the cancer.Type: GrantFiled: October 9, 2019Date of Patent: November 15, 2022Assignee: ImmunSYS, Inc.Inventors: Gary Onik, James A. Miessau
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Patent number: 11457976Abstract: A medical device for directionally focusing energy to a treatment site, the medical device including a shaft having an elongated body defining a proximal portion and a distal portion opposite the proximal portion, the distal portion including at least one electrode having a contact portion and a permeable sheath at least partially surrounding the at least one electrode, the permeable sheath and the at least one electrode defining an insulation cavity, the permeable sheath being impermeable to an insulation material introduced to the insulation cavity from a fluid source configured to be coupled to the shaft.Type: GrantFiled: January 8, 2019Date of Patent: October 4, 2022Assignee: Medtronic, Inc.Inventors: Mark T. Stewart, Brian T. Howard
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Patent number: 11382790Abstract: A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.Type: GrantFiled: April 27, 2017Date of Patent: July 12, 2022Assignee: Zeltiq Aesthetics, Inc.Inventors: Leonard C. DeBenedictis, Joel N. Jimenez Lozano, Like Zeng, George Frangineas, Jr., Linda Pham
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Patent number: 11377685Abstract: A base sequence determination apparatus includes (1) a mobility correction unit that outputs a mobility correction signal obtained by mobility correction of a time-series signal of a wavelength spectrum corresponding to each base, (2) a deconvolution unit that executes processes for calculating a deconvoluted signal of the mobility correction signal respectively for a plurality of parameter candidates of point spread function, calculating variance of peak intervals for the calculated deconvoluted signal, specifying a parameter of the point spread function using the calculated variance, and outputting the deconvoluted signal corresponding to the point spread function having the specified parameter as an updated deconvoluted signal, (3) a peak extracting unit that extracts a peak waveform from the updated deconvoluted signal and outputs an updated peak-extracted signal, and (4) a sequence specifying unit that inputs the updated peak-extracted signal and determines a base sequence.Type: GrantFiled: January 28, 2016Date of Patent: July 5, 2022Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Yohei Kawaguchi, Tomohiro Yasuda, George Chalkidis, Takahide Yokoi
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Patent number: 11357563Abstract: A system and method for controlling the inflation, ablation, and deflation of a balloon catheter. The system includes a balloon catheter, a console, a pressurized gas or liquid inflation source, and an umbilical system to deliver pressurized coolant to the balloon catheter. The system may include controller that monitors the amount of pressure and volume within the balloon catheter. During inflation, the pressure and/or volume of fluid within the balloon is maintained at a target amount in order to provide sufficient mechanized pressure against the desired target region. The system limits the inflation pressure such that a safe quantity of gas would be released should a leak occur. If the amount falls below a certain threshold level, gas or fluid egress is presumed and the inflation process is halted.Type: GrantFiled: October 16, 2017Date of Patent: June 14, 2022Inventors: Marwan Abboud, Rachid Mahrouche, Chadi Harmouche, Teresa Ann Mihalik, Gilles Desrochers
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Patent number: 11350992Abstract: Methods for treating a human patient diagnosed with cancer with therapeutic neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological processes associated with the progression of cancer. One aspect of the present technology is directed to methods that attenuate neural traffic along target sympathetic nerves innervating tissue proximate a primary malignant tumor. Other aspects are directed to methods that at least partially inhibit sympathetic neural activity in a renal nerve of a patient diagnosed with cancer or who has a high risk of developing cancer. Targeted sympathetic nerve activity can be attenuated to improve a measurable physiological parameter corresponding to the progression of cancer in the patient. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g.Type: GrantFiled: July 31, 2020Date of Patent: June 7, 2022Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.Inventors: Garrett Pilcher, Robert Melder
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Patent number: 11344355Abstract: A cryoprobe having a working tip formed of two coaxial flexible internal and external tubular lines, wherein the cross-section diameter of the internal line is substantially smaller than the cross-section diameter of the external line, and the length is slightly smaller than the length of the external line. The external line ends with a top closing the working tip of the cryoprobe, while the end of the internal line is open, and there are openings evenly distributed across the circumference on at least half of the section of the internal line. On the section from the handle to the end located under the top, a resistance wire is spirally wound on the internal line, wherein the distance between the wall of the external line and the wall of the internal line is larger than the diameter of the resistance wire. On the external line, no further from the top located on the top of the working tip than ? of the length thereof, there is a temperature sensor connected to the handle by a power line.Type: GrantFiled: November 16, 2018Date of Patent: May 31, 2022Assignee: Medidata Sp. z o.o.Inventors: Piotr Suwalski, Choudhary Sanjeev, Cezary Górniak
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Patent number: 11337745Abstract: A device for treatment of acne includes: a case having a contact surface portion to contact a skin of an acne region, the contact surface portion being provided with at least one through hole; at least one needle inserted into the skin of the acne region through the through hole with the contact surface portion arranged in contact with the skin; a driving unit arranged inside the case; a needle fixing part arranged inside the case so as to fix the at least one needle and configured to be linearly moved by the driving unit; and a needle cooling unit configured to cooling the at least one needle to transfer coldness into the skin of the acne region through the at least one needle to suppress a function of a sebaceous gland in the skin of the acne region such that proliferation of propionibacterium acnes is limited.Type: GrantFiled: May 29, 2018Date of Patent: May 24, 2022Assignee: ILOODA Co., Ltd.Inventor: Young Han Kim
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Patent number: 11266458Abstract: A surgical cryoablation system comprising a valve having a valve inlet and a valve outlet the valve inlet connectable to a source of cryogenic fluid at a pressure of greater than 4000 psi and the valve outlet connectable to a cryoablation probe, such that the valve outlet is in fluid communication with the cryoprobe such that the source of cryogenic fluid is in fluid communication with the valve inlet.Type: GrantFiled: April 19, 2019Date of Patent: March 8, 2022Assignee: BOSTON SCIENTIFIC SCIMED, INC.Inventors: Ted Jerome Perron, Sean M. Morgan
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Patent number: 11266456Abstract: An ablation assembly includes a handle, a catheter assembly and a connector locking assembly. The catheter assembly includes: a catheter shaft, a balloon and a connector at the distal and proximal ends of the catheter shaft, and a delivery tube extending between there between. The connector includes a connector body secured to the proximal end and a plug secured to the delivery tube, the plug and delivery tube movable axially and rotationally. The handle includes an open portion receiving the plug and the connector body. The connector locking assembly includes: means for simultaneously automatically connecting the plug and the connector body to the handle to place the connector in a load state prior to use, and means for automatically releasing the connector body and thereafter the plug from the handle to place the connector in an eject state to permit the connector to be removed from the handle.Type: GrantFiled: October 25, 2018Date of Patent: March 8, 2022Assignee: PENTAX OF AMERICA, INC.Inventors: Gabriel F. W. Newell, Patrick P. Wu, Timothy Douglas Holland, Cesar A. Ico, Dennis Franklin Burke
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Patent number: 11241526Abstract: Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting.Type: GrantFiled: November 6, 2018Date of Patent: February 8, 2022Assignee: University of Virginia Patent FoundationInventors: William J. Elias, Aaron E. Bond, George T. Gillies
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Patent number: 11213338Abstract: A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.Type: GrantFiled: December 18, 2018Date of Patent: January 4, 2022Assignee: Aegea Medical Inc.Inventors: Hugh R. Sharkey, Ramiro Reyes, Kurt D. Sparks
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Patent number: 11207117Abstract: The present disclosure relates generally to the field of cryotherapy. In particular, the present disclosure relates to cryotherapy systems that ensure egress of cryogen gas delivered within a patient's body during cryotherapy procedures and, more particularly, sensors for use with cryotherapy systems that include delivery catheters wherein the systems ensure that egress of cryogen gas from the patient's body is possible whenever the catheter is operating.Type: GrantFiled: March 7, 2018Date of Patent: December 28, 2021Assignee: CSA Medical, Inc.Inventors: Sean A. McDermott, Charles J. Vadala, Brian M. Hanley, John P. O'Connor
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Patent number: 11154351Abstract: Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.Type: GrantFiled: November 14, 2015Date of Patent: October 26, 2021Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.Inventors: Martin Rothman, Paul Coates
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Patent number: 11141209Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.Type: GrantFiled: September 10, 2018Date of Patent: October 12, 2021Inventors: Jean-Pierre Lalonde, Regina E. Groves, Timothy G. Laske, Paul A. Iaizzo, John C. Bischof
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Patent number: 11103296Abstract: An ablation applicator for an ablation device for ablating tissue of a blood vessel having a tubular body defining an inner lumen to which an ablation medium is conductable, a control mechanism for converting the tubular body between a passive operation mode for inserting the ablation applicator into the blood vessel and an active operation mode for ablating tissue of the blood vessel, and an ablation medium supply line for supplying the ablation medium to the inner lumen and positioned within the inner lumen and having a number of openings for passing the ablation medium from the ablation medium supply line to the inner lumen for thermally contacting the ablation medium with the tubular body wherein at least some of the openings are distributed along the ablation medium supply line with a predetermined spacing between neighboring openings.Type: GrantFiled: February 28, 2018Date of Patent: August 31, 2021Assignee: Afreeze GmbHInventors: Gerald Fischer, Florian Hintringer
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Patent number: 11089961Abstract: Embodiments of a system can include a temperature monitoring device including: a heat flux channel, a first temperature sensor thermally coupled to the heat flux channel, a second temperature sensor thermally coupled to the heat flux channel, a thermal cage thermally coupled to and arranged around the heat flux channel along a length of the heat flux channel, and a processing system operable to determine a core body temperature measurement based on temperature data collected at the first and the second temperature sensors.Type: GrantFiled: August 21, 2017Date of Patent: August 17, 2021Inventor: James Foody
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Patent number: 11045245Abstract: A cryotreatment catheter for treating tissue. The catheter may include an outer elongate body, a balloon treatment element coupled to the distal portion of the elongate body with a plurality of balloon lobes radially arranged around the outer elongate body, an inner elongate body rotatably movable within the lumen of the outer elongate body, and a fluid delivery lumen located within the lumen of the outer elongate body and at least partially within the lumen of the inner elongate body. The fluid delivery lumen may be branched at a distal portion into a plurality of linear segments, each linear segment being in fluid communication with one of the plurality of balloon lobes. Each of the balloon lobes may be inflated independently of each other by the linear segments of the fluid delivery lumen.Type: GrantFiled: March 28, 2019Date of Patent: June 29, 2021Inventors: Rahmani Sara, Lies Safar Remali
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Patent number: 11026739Abstract: The present invention provides a medical system, including a catheter defining an injection lumen, a chamber in fluid communication with the injection lumen, and an exhaust lumen in fluid communication with the chamber; a first temperature sensor positioned in the exhaust lumen proximal to the chamber; a second temperature sensor positioned in the chamber; and a console in electrical communication with the first and second temperature sensors, the controller modifying coolant flow through the medical device based at least in part upon a signal received from the first and second temperature sensor. The system may further include a thermally-conductive element circumscribing a substantial portion of the exhaust lumen proximal to the chamber, where the first temperature sensor is mounted to the thermally-conductive element, and the thermally-conductive element may include at least one of a braid, coil, and band.Type: GrantFiled: March 13, 2018Date of Patent: June 8, 2021Assignee: Medronic CryoCath LPInventors: Jean-Pierre Lalonde, Dan Wittenberger, Marwan Abboud, Constantin Bogdan Ciobotaru, Ramin Sabbaghe-Kermani
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Patent number: 11020163Abstract: A surgical instrument includes an outer shaft defining a passageway. An inner shaft is disposed within the passageway and defines a lumen. An expandable structure has a first end coupled to a second end of the outer shaft and a second end coupled to a second end of the inner shaft. The expandable member defines a chamber. A delivery shaft includes a first end positioned within the passageway and a second end positioned within the chamber. The delivery shaft defines a channel configured to deliver a coolant out of an opening in the second end of the delivery shaft and into the chamber to move the expandable structure from an unexpanded configuration to an expanded configuration. A variable exhaust valve is in communication with the passageway and is configured to regulate pressure within the chamber. Systems and methods are disclosed.Type: GrantFiled: March 14, 2018Date of Patent: June 1, 2021Assignee: MEDTRONIC HOLDING COMPANY SARLInventor: Stephen Nash
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Patent number: 11007078Abstract: An apparatus includes a shaft having a proximal end and a distal end; a stem extending from the distal end of the shaft and comprising a first cover and a second cover, the first cover and the second cover being configured to inhibit access to fallopian tubes of a patient; and a plurality of temperature sensors disposed on the shaft and on the stem. At least one of the temperature sensors is positioned between the proximal end of the shaft and the distal end of the shaft and at least one of the temperature sensors is positioned on the stem.Type: GrantFiled: March 19, 2018Date of Patent: May 18, 2021Assignee: Gyrus Acmi, Inc.Inventor: Nikhil Murdeshwar
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Patent number: 10952792Abstract: Provided herein are devices, systems, and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, devices, systems, and methods are provided for delivering energy to difficult to access tissue regions (e.g. central or peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.Type: GrantFiled: October 26, 2016Date of Patent: March 23, 2021Assignee: Neuwave Medical, Inc.Inventors: Matthew Thiel, Mark Thom, Richard W. Schefelker, Jeff Bissing, Yaniv Lazimy, Matt Schaning, Dave Anderson
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Patent number: 10946179Abstract: The invention disclosed herein is a gastrostomy tube reinsertion device. The present invention provides a dilation device for dilating the gastrostomy tube tract in living tissues. In one aspect, the gastrostomy tube reinsertion device comprises multiple dilators to open collapsed soft tissue within the gastrostomy tube tract. Such device is useful for reinserting a gastrostomy tube into the previously defined tract in a human body, even after partial closure of the tract and gastrostomy tube insertion site. In another aspect, the present invention provides the method or steps for reinserting a gastrostomy tube into a patient.Type: GrantFiled: August 4, 2017Date of Patent: March 16, 2021Inventor: Adolfo Napolez
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Patent number: 10932853Abstract: A device is described for treating a nasal airway by modifying a property of a nasal tissue of or near a nasal valve of the airway, without using a surgical incision or an implant, to decrease airflow resistance or perceived airflow resistance in the nasal airway. Various embodiments include an elongate shaft, a bipolar radiofrequency delivery member extending from one end of the shaft, and a handle attached to the elongate shaft at an opposite end from the radiofrequency delivery member. The radiofrequency delivery member is sized to be inserted into a nose and configured to at least temporarily deform the nasal tissue and deliver radiofrequency energy. The radiofrequency delivery member includes two rows of protruding electrodes disposed on a tissue contact surface, and the device is configured to deliver radiofrequency energy from one row of electrodes to the other row of electrodes.Type: GrantFiled: July 25, 2019Date of Patent: March 2, 2021Assignee: AERIN MEDICAL, INC.Inventors: Scott J. Wolf, Andrew Frazier
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Patent number: 10905490Abstract: Cryotherapeutic devices for renal neuromodulation and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having a distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator having a distributor in fluid communication with the supply lumen and a balloon configured to deliver cryotherapeutic cooling to nerves proximate the treatment site when the cooling assembly is in a deployed state.Type: GrantFiled: May 4, 2017Date of Patent: February 2, 2021Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Benjamin J. Clark, David J. Hobbins, Tim Huynh, Grace Kelly, Brian Kelly
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Patent number: 10893819Abstract: A system and method for Brugada syndrome epicardial ablation comprising preparing an endocardial duration map; preparing a baseline epicardial duration map comprising at least one or more areas of delimination; and when some of the areas of delimination are greater than 200 ms, performing epicardial ablation of the areas of delimination greater than 200 ms. The method may further comprise preparing an updated epicardial duration map after performing epicardial ablation, and determining whether or not a BrS pattern appears in the updated epicardial duration map; and when the BrS pattern appears, performing epicardial ablation. The method may further comprise preparing an updated epicardial duration map after performing epicardial ablation, and determining whether or not an abnormal EGM exists in the updated epicardial duration map; and when the abnormal EGM exists, performing epicardial ablation.Type: GrantFiled: December 26, 2017Date of Patent: January 19, 2021Assignee: Biosense Webster (Israel) Ltd.Inventors: Carlo Pappone, Aharon Turgeman, Paolo Roberto Pozzi, Andrea Natalizia
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Patent number: 10888377Abstract: The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.Type: GrantFiled: May 7, 2018Date of Patent: January 12, 2021Assignee: DIGMA MEDICAL LTD.Inventors: Ilan Ben-Oren, Avia Herschkovitz, Tamir Wolf, Irit Yaniv
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Patent number: 10869779Abstract: Embodiments include methods and systems for treating joint pain associated with a nerve. A needle of a cryogenic system may be inserted beneath a skin surface. The needle may include an electrically conducting structure at least partially surrounded by an electrical insulator for conducting electrical energy. The needle may include an outer lumen and an inner lumen extending distally within the outer lumen, the inner lumen include a distal opening open to the outer lumen. The needle may be positioned at a desired location in proximity to the nerve, and a cooling therapy including cooling cycles and thawing periods may be performed to cool tissue at the desired location. The cooling therapy may sufficiently reduce the joint pain.Type: GrantFiled: February 20, 2020Date of Patent: December 22, 2020Assignee: Pacira CryoTech, Inc.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Patent number: 10864112Abstract: Embodiments include methods and systems for treating back pain associated with a nerve. A needle of a cryogenic system may be inserted beneath a skin surface. The needle may include an electrically conducting structure at least partially surrounded by an electrical insulator for conducting electrical energy. The needle may include an outer lumen and an inner lumen extending distally within the outer lumen, the inner lumen include a distal opening open to the outer lumen. The needle may be positioned at a desired location in proximity to the nerve, and a cooling therapy including cooling cycles and thawing periods may be performed to cool tissue at the desired location. The cooling therapy may sufficiently reduce the back pain.Type: GrantFiled: February 20, 2020Date of Patent: December 15, 2020Assignee: Pacira CryoTech, Inc.Inventors: Keith Burger, Lisa Elkins, Ronald Williams
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Patent number: 10847778Abstract: A cooling lance is provided to cool an electrically conductive contact body. The cooling lance includes a lance body, a fluid line extending through the lance body, and a flexible cooling bladder positioned on an end of the lance body and in fluidic communication with the fluid line.Type: GrantFiled: August 14, 2019Date of Patent: November 24, 2020Assignee: TE Connectivity Germany GmbHInventors: Andre Martin Dressel, Gerzson Toth, Rudi Blumenschein, Frank Kaehny
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Patent number: 10828099Abstract: Cardiac catheterization is conducted using a probe having a balloon assembly, in which a spring has a resting axially elongated configuration and a torsed, axially shortened configuration. A balloon is twisted about the spring and mechanically linked to the spring. A flexible sheath is disposed about the spring within the balloon, the sheath and the wall of the balloon defining a chamber to contain a fluid flowing therein and thereout of the balloon.Type: GrantFiled: February 13, 2018Date of Patent: November 10, 2020Assignee: Biosense Webster (Israel) Ltd.Inventors: Christopher Thomas Beeckler, Joseph Thomas Keyes, Rowan Olund Hettel
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Patent number: 10786296Abstract: A device, method, and system for thermally affecting tissue. The device may generally include an elongate body, an actuation element slidably disposed within the elongate body, a balloon defining an interior chamber, a proximal neck, and a distal neck, the first neck being coupled to the distal portion of the elongate body and the second neck being coupled to the distal portion of the actuation element, retraction of the actuation element within the elongate body causing the treatment element to transition from a first configuration to a second configuration. The distal neck may be located external to the interior chamber in the first configuration and within the interior chamber in the second configuration. The device may also include a fluid injection element that is transitionable to an expanded configuration when the balloon is inflated, thereby enhancing the cooling capacity of the balloon.Type: GrantFiled: November 14, 2017Date of Patent: September 29, 2020Assignee: Medtronic CryoCath LPInventors: Jean-Pierre Lalonde, Scott W. Davie
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Patent number: 10758292Abstract: A method and system of providing therapy to a patient's uterus. The system has an access tool with a lumen, the access tool being adapted to be inserted through a human cervical canal to place an opening of the lumen within a uterus when the access tool is inserted through the cervical canal; a seal disposed at a distal region of the access tool and adapted to seal the access tool against an interior cervical os; a sealing indicator adapted to provide a user with an indication that the seal has sealed the access tool with the interior cervical os; and a vapor delivery mechanism adapted to deliver condensable vapor through the access tool to the uterus, the condensable vapor being adapted to condense within the uterus.Type: GrantFiled: December 18, 2018Date of Patent: September 1, 2020Assignee: AEGEA MEDICAL INC.Inventors: Hugh R. Sharkey, Ramiro Reyes, Kurt D. Sparks
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Patent number: 10695126Abstract: Ablation catheters and systems include coaxial catheter shafts with an inner lumen for delivering an ablative agent and an outer lumen for circulation of a cooling element about the catheter. Induction heating is used to heat a chamber and vaporize a fluid within by wrapping a coil about a ferromagnetic chamber and providing an alternating current to the coil. A magnetic field is created in the area surrounding the chamber which induces electric current flow in the chamber, heating the chamber and vaporizing the fluid inside. Positioning elements help maintain the device in the proper position with respect to the target tissue and also prevent the passage of ablative agent to normal tissues.Type: GrantFiled: May 19, 2017Date of Patent: June 30, 2020Inventor: Virender K. Sharma
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Patent number: 10695041Abstract: A positioning device is configured to selectively position or otherwise manipulate one or more organs within the body of a subject. The positioning device includes a shaped expandable element that is configured to be selectively transitioned between an unexpanded, or collapsed, state and an expanded state. While in the expanded state, the expandable element repositions or otherwise manipulates an organ. Systems that include positioning devices are also disclosed, as are methods for positioning or otherwise manipulating organs.Type: GrantFiled: August 23, 2017Date of Patent: June 30, 2020Assignee: Manual Surgical Sciences LLCInventor: Shawn P. Fojtik
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Patent number: 10682170Abstract: An intravascular catheter is provided, including a flexible elongate body; an expandable element positioned on the elongate body; a substantially linear thermal segment located proximally of the expandable element, the thermal segment defining a first flexibility, where the thermal segment is positioned between two portions of the catheter body each including a flexibility less than that of the thermal segment; a first fluid flow path in fluid communication with the expandable element; and a second fluid flow path in fluid communication with the thermal segment.Type: GrantFiled: January 20, 2016Date of Patent: June 16, 2020Assignee: Medtronic CryoCath LPInventor: Jean-Luc Pageard
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Patent number: 10667854Abstract: An endovascular near critical fluid based cryoablation catheter for creating an elongated lengthwise-continuous lesion in tissue can comprise an elongated shaft, a flexible distal tissue treatment section, and a distal tip. A plurality of flexible tubes can extend through the distal treatment section to transport a near critical fluid to and from the distal tip. The distal treatment section can also include a flexible fluid-sealed cover or barrier layer surrounding the delivery tubes. The cover and tubes can collectively define a space which is filled with a fluidic thermally conductive media. The thermally conductive media, fluid delivery tubes, and the cover can be arranged such that a flow of the near critical fluid through the tube bundle transfers heat between a target tissue and the distal treatment section of the catheter thereby creating the elongated lengthwise-continuous lesion in the tissue.Type: GrantFiled: September 22, 2014Date of Patent: June 2, 2020Assignee: Adagio Medical, Inc.Inventors: Alexei V. Babkin, Steven W. Kovalcheck, Xiaoyu Yu
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Patent number: 10636324Abstract: Training device for training tracheal suctioning. The training device includes a tracheal core adapted to be arranged within a tracheal, nasal or oral cavity of a medical training simulator, and coupled to the airways of the simulator and an insert adapted to be inserted into the core, the insert forming a reservoir for simulated mucus.Type: GrantFiled: December 21, 2017Date of Patent: April 28, 2020Assignee: Laerdal Medical ASInventors: Greg Necessary, Ben Tedeschi, Paul Griffith, David Thane
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Patent number: 10610280Abstract: The embodied invention is a method of removing intraperitoneal fat by using a freezing cryoprobe and inserting it into the abdominal cavity. The freezing cryoprobe is covered by a vacuum sleeve which provides for a method for abdominal fat removal once the cells are damaged. A multi-step surgical procedure is used to freeze, irrigate, and remove the destroyed fat tissue. Also, an ultrasonic transmitter is inserted into an outer cryoprobe sheath to assess organ position with the advantage of an internal transmitter which greatly aids in organ identification.Type: GrantFiled: February 2, 2019Date of Patent: April 7, 2020Inventor: Ayad K. M. Agha
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Patent number: 10596030Abstract: A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.Type: GrantFiled: March 9, 2017Date of Patent: March 24, 2020Assignee: Pacira CryoTech, Inc.Inventors: Jwala Karnik, Jason Reynolds, John Allison, Clint Carnell
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Patent number: 10588682Abstract: Embodiments related to cryogenically ablating a portion of the inner surface of a vessel by constraining a cryoballoon using various apparatuses and methods are disclosed. For example, a catheter can include a cryoballoon for ablation of the vessel wall and a constraining element disposed substantially in parallel with the cryoballoon to deflect or offset a portion of the cryoballoon away from non-target tissue of the vessel wall and prevent ablation of the non-target tissue. Partial circumferential, non-continuous, or helical ablation can be effective for treating a variety of renal, cardio-renal, and other diseases including but not limited to hypertension, heart failure, renal disease, renal failure, contrast nephropathy, arrhythmia, and myocardial infarction. The constraining element may be, for example, a second inflatable balloon or one or more self-expanding prongs.Type: GrantFiled: June 12, 2014Date of Patent: March 17, 2020Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.Inventors: Brian Kelly, John Kelly, Gary P. Kelly, Barry Mullins
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Patent number: 10512460Abstract: A system (10) including an helicoidal member (16); an elongated guide (26) positionable at least partially through the helicoidal member (16) along the longitudinal axis of helicoidal member (16), the guide (26) defining a longitudinally extending peripheral surface cooled portion (32); a cooling subsystem (33) for cooling the peripheral surface cooled portion (32); and a driver (34) for mounting the helicoidal member (16) thereto and rotating the helicoidal member (16) along the helicoidal member longitudinal axis while allowing the helicoidal member (16) to advance along the guide (26) in a distally oriented direction.Type: GrantFiled: December 19, 2015Date of Patent: December 24, 2019Inventors: Toufic Azar, Renzo Cecere
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Patent number: 10478633Abstract: Combined methods for treating a patient using time-varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.Type: GrantFiled: November 20, 2018Date of Patent: November 19, 2019Assignee: BTL Medical Technologies S.R.O.Inventors: Tomás Schwarz, Ondra Prouza
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Patent number: 10471269Abstract: Combined methods for treating a patient using time-varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.Type: GrantFiled: November 20, 2018Date of Patent: November 12, 2019Assignee: BTL Medical Technologies S.R.O.Inventors: Tomás Schwarz, Ondra Prouza
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Patent number: 10456185Abstract: A method for reshaping a nasal airway in a patient involves advancing an inflatable balloon of a reshaping device in an uninflated configuration into a nostril of the patient and between a nasal septum and a lateral wall of the nasal airway. The method then involves inflating the inflatable balloon to an inflated configuration to cause the inflatable balloon to contact nasal mucosa covering the nasal septum and the lateral wall, delivering energy from an energy delivery member attached to or inside of the inflatable balloon, and removing the reshaping device from the nasal airway.Type: GrantFiled: June 6, 2019Date of Patent: October 29, 2019Assignee: AERIN MEDICAL, INC.Inventors: Scott J. Wolf, Andrew Frazier