Collagen Containing Patents (Class 606/229)
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Patent number: 11285246Abstract: Medical grade yarns, medical devices constructed of such yarns, and methods for making such yarns and devices are described. Polyester drawn fibers, and more particularly high strength and high tenacity micro polyester fibers for use in medical devices, and methods of preparing the same are provided.Type: GrantFiled: September 8, 2020Date of Patent: March 29, 2022Assignee: RxFiber, LLCInventor: Robert D. Torgerson
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Patent number: 10905413Abstract: A surgical suture having enhanced visual characteristics is provided. The suture has a suture filament operatively coupled to a suture needle. The suture filament includes a useful segment and a terminal segment. The terminal segment is located at a first end of the filament. The useful segment extends substantially from the terminal segment to a second end of the filament. The terminal segment is of a length of the filament that is left-over after a substantially last formable suture knot is formed using the useful segment. After the last formable suture knot is formed, the terminal segment is removed from the useful segment along with the suture needle for disposal. In order to enable visual location of the terminal segment after the same has been separated from the useful segment, the filament is treated such that that the terminal segment has distinctive contrasting light frequency characteristics.Type: GrantFiled: October 28, 2016Date of Patent: February 2, 2021Assignee: Dr. Stan M. Valnicek Inc.Inventor: Stanley Michael Karl Valnicek
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Patent number: 10808355Abstract: A high-strength fibre rope (1) comprising a rope core as well as a sheathing indicating optical wear, wherein the sheathing comprises a sheath layer (2) made up of textile subunits (3, 4) of a first hierarchy level. An outermost sheath layer (2) is provided, wherein textile subunits (3, 4) of said outermost sheath layer of the first hierarchy level differ from each other in terms of their textile structure, and/or an outermost sheath layer and a further sheath layer underneath said outermost sheath layer are provided, and wherein the textile subunits of the first hierarchy level of said outermost sheath layer differ in their textile structure from that of said further sheath layer. The textile subunits of a lowermost hierarchy level of the rope are neither dispersed in a resin matrix in the outermost sheath layer nor in the further sheath layer arranged underneath the outermost sheath layer.Type: GrantFiled: April 19, 2018Date of Patent: October 20, 2020Assignee: TEUFELBERGER FIBER ROPE GMBHInventors: Peter Baldinger, Robert Traxl, Gunter Kaiser, Rudolf Kirth, Björn Ernst, Erich Rührnössl
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Patent number: 10786237Abstract: A method of reinforcing a biological construct according to an exemplary aspect of the present disclosure includes, among other things, attaching a suture loop/needle construct to a reinforcement material and stitching the reinforcement material to a biological construct to form a reinforced biological construct. The reinforcement material is attached to the suture loop/needle construct prior to approximating the reinforcement material to the biological construct.Type: GrantFiled: August 23, 2018Date of Patent: September 29, 2020Assignee: ARTHREX, INC.Inventors: James J. Guerra, Jacob A. Jolly, Dustin T. Libby, Thomas M. Deberardino
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Patent number: 9669012Abstract: Disclosed herein are delivery systems including coated and uncoated yarns, yarn precursors, threads, fibers, and other substrates for the constant or near-constant release of active compounds, as well as methods for manufacturing such delivery systems. The yarns, yarn precursors, threads, fibers, and other substrates can include a cross-linked hydrophobic elastomer and an active compound. One or more coatings that are impermeable or substantially impermeable to the active compound may partially or fully occlude the yarn or substrate to control release rates of the active compound. The delivery systems may be used in a variety of applications, including the making of articles of clothing, textiles, and fabrics, and may be used in methods of treating various conditions and diseases.Type: GrantFiled: October 29, 2015Date of Patent: June 6, 2017Assignee: Textile-Based Delivery, Inc.Inventors: David Anderson, Jordan Schindler, Erik Scott Goebel
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Patent number: 9295462Abstract: This invention relates to a suture including a drug-loaded polymer layer and a method of manufacturing the same, and more particularly, to a suture, the surface of which is wound with a film including a drug-loaded biodegradable polymer layer, or coated with a drug-loaded biodegradable polymer layer, and to a method of manufacturing the same.Type: GrantFiled: November 25, 2011Date of Patent: March 29, 2016Assignee: SNU R&DB FOUNDATIONInventors: Young Bin Choy, Chan Yeong Heo, Ji Eun Lee, Su Bin Park
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Patent number: 9186432Abstract: A high strength surgical suture formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with native or denatured collagen. The braided jacket surrounds a core formed of twisted yarns of ultrahigh molecular weight polyethylene. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.Type: GrantFiled: June 15, 2012Date of Patent: November 17, 2015Assignee: Arthrex, Inc.Inventors: Augustus D. Mazzocca, MaryBeth McCarthy
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Patent number: 9161750Abstract: Assemblies, devices and methods are provided for suture management associated with surgical procedures for anchoring suture to bone. Suture elements mounted to suture anchors are terminated in suture loops or tags, and associated stop members that in combination with visual coding provide suture identification, prevent accidental unmounting of suture from suture anchors, and reduce the number of suture legs requiring active management during complex arthroscopic repairs. The present invention also provides exemplary drivers that can be used with the various methods and devices disclosed herein, or with other methods and devices known in the art.Type: GrantFiled: August 12, 2014Date of Patent: October 20, 2015Assignee: DePuy Mitek, LLCInventors: Christopher T. Zirps, Charles S. Brunner, Jeffrey S. Hovis, Chris Kilburn-Peterson
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Publication number: 20150032155Abstract: A hybrid monofilament/braided surgical suture that combines a monofilament with a braided construction. The hybrid surgical suture may be formed by braiding yarns of high tenacity fibers tightly over a core in the form of a monofilament yarn. The monofilament may be any type of material, for example, a nylon, silk, polyester, polyethylene or polypropylene filament, among many others. The stiffness properties of the hybrid surgical suture allow the suture to be pushed through small and very small diameter tubes and cannulations (such as Lasso instruments, for example) yet fix securely with existing fixation devices (such as knotless suture anchors like PushLock® anchors).Type: ApplicationFiled: July 23, 2014Publication date: January 29, 2015Inventors: Peter J. Dreyfuss, Thomas Dooney, JR.
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Publication number: 20140213966Abstract: A medical device includes an elongated body including an outer surface having a plurality of barbs extending therefrom and an inner surface defining a lumen therethrough. The elongated body includes at least one channel extending through the inner surface and the outer surface, the channel defined between an inner surface of one of the plurality of barbs and a cut outer surface of the elongated body. A wound treatment material is disposed within the lumen of the elongated body. The barb is configured to move between a first position to close the channel and retain the wound treatment material within the lumen and a second position to open the channel and permit the release of the wound treatment material therethrough.Type: ApplicationFiled: January 7, 2014Publication date: July 31, 2014Applicant: Covidien LPInventors: Roland Ostapoff, Timothy Sargeant
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Publication number: 20140142626Abstract: The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production.Type: ApplicationFiled: January 23, 2014Publication date: May 22, 2014Applicants: COVIDIEN LP, SOFRADIM PRODUCTIONInventors: Ahmad Robert HADBA, Sebastien LADET
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Patent number: 8470354Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.Type: GrantFiled: January 8, 2010Date of Patent: June 25, 2013Assignee: Warsaw Orthopedic, Inc.Inventors: William F. McKay, Scott D. Boden, Neil B. Beals
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Patent number: 8470356Abstract: Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.Type: GrantFiled: November 4, 2010Date of Patent: June 25, 2013Assignee: Cook Biotech IncorporatedInventors: Umesh H. Patel, F. Joseph Obermiller, Bhavin Shah, Chad E. Johnson
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Publication number: 20130103079Abstract: A material comprising two or more fibers, wherein each of the fibers has a mechanical modulus, and the mechanical modulus of at least one fiber is higher than the mechanical modulus of another fiber. The higher modulus fiber has a longer length than the lower modulus fiber. In various embodiments, the higher modulus fiber is collagen mimetic and the lower modulus fiber is elastin mimetic. A suture is also described, comprising two or more fibers. At least one of the fibers is elastin-like and has a lower elastic modulus than another fiber that is collagen-like and has a higher elastic modulus. The higher modulus collagen-like fiber is longer than the lower modulus elastin-like fiber.Type: ApplicationFiled: October 24, 2012Publication date: April 25, 2013Applicant: NOVO CONTOUR, INC.Inventor: Novo Contour, Inc.
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Publication number: 20130072974Abstract: The present invention provides that coatings applied to natural, synthetic and recombinant expressed polymer filaments can be used to modify the properties of monofilament and multifilament self-retaining sutures. In an embodiment of the invention, the coating enables the suture to be easily inserted into tissue, whereupon the extended interaction of the coating and the tissue increase the ability of the tissue retainers to hold the suture in the tissue. In an embodiment of the present invention, the coated polymers have a melting point in the range from between approximately 40° C. to approximately 180° C. while retaining tensile strength. In an embodiment of the invention, the increased strength is due in part to the tissue specific reaction generated by the suture coating.Type: ApplicationFiled: March 7, 2012Publication date: March 21, 2013Inventor: William L. D'Agostino
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Patent number: 8383188Abstract: A high strength surgical suture material with improved tie down characteristics and tissue compliance formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with arginine-glycine-aspartate (RGD) peptide. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.Type: GrantFiled: July 19, 2011Date of Patent: February 26, 2013Assignee: University of ConnecticutInventors: Augustus D. Mazzocca, Mary Beth McCarthy
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Publication number: 20130018415Abstract: Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.Type: ApplicationFiled: July 10, 2012Publication date: January 17, 2013Inventors: Rebeccah Brown, Thomas J. Koob
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Publication number: 20120259360Abstract: A high strength surgical suture formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with native or denatured collagen. The braided jacket surrounds a core formed of twisted yarns of ultrahigh molecular weight polyethylene. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.Type: ApplicationFiled: June 15, 2012Publication date: October 11, 2012Inventors: Augustus D. Mazzocca, Mary Beth McCarthy
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Publication number: 20120150221Abstract: According to an aspect of the present disclosure, a surgical suture needle assembly is provided including an elongate tube defining a lumen through at least a portion of a length thereof; and a wound treatment material contained within the lumen of the suture structure. The present disclosure further provides for methods of using the surgical suture needle assembly in anastomotic procedures and the like.Type: ApplicationFiled: February 17, 2012Publication date: June 14, 2012Applicant: Tyco Healthcare Group LPInventor: Frank J. Viola
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Patent number: 8142475Abstract: According to an aspect of the present disclosure, a surgical suture needle assembly is provided including an elongate tube defining a lumen through at least a portion of a length thereof; and a wound treatment material contained within the lumen of the suture structure. The present disclosure further provides for methods of using the surgical suture needle assembly in anastomotic procedures and the like.Type: GrantFiled: October 14, 2005Date of Patent: March 27, 2012Assignee: Tyco Healthcare Group LPInventor: Frank J. Viola
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Patent number: 8092823Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.Type: GrantFiled: January 8, 2010Date of Patent: January 10, 2012Assignee: Warsaw Orthopedic, Inc.Inventors: William F. McKay, Scott D. Boden, Neil B. Beals
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Patent number: 8080521Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.Type: GrantFiled: December 23, 2010Date of Patent: December 20, 2011Assignee: Warsaw Othopedic, Inc.Inventors: Neil B. Beals, Jeffrey L. Scifert, Scott D. Boden
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Publication number: 20110178549Abstract: The invention relates to a surgical suture formed from an acellular, collagen based tissue material. After healing, the suture material will not absorb into the host, but will act as a structural template that will repopulate with viable cells from the host.Type: ApplicationFiled: October 25, 2010Publication date: July 21, 2011Inventor: Zsuzsanna Juhasz
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Patent number: 7850894Abstract: Various methods are provided for forming tissue holding devices having predetermined shapes suitable for use in surgical applications, and devices formed in accordance with such methods are also provided. These methods include press forming methods, and press forming methods in combination with profile punching. Tissue holding devices formed in accordance with such methods include various configurations for a core and a plurality of tissue holding elements extending outwardly from the core.Type: GrantFiled: May 2, 2007Date of Patent: December 14, 2010Assignee: Ethicon, Inc.Inventors: David Lindh, Sr., Jesse G. Nawrocki, John P. Collier
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Patent number: 7850985Abstract: Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.Type: GrantFiled: July 5, 2006Date of Patent: December 14, 2010Assignee: Cook Biotech IncorporatedInventors: Umesh H. Patel, F. Joseph Obermiller, Bhavin Shah, Chad E. Johnson
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Patent number: 7722895Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.Type: GrantFiled: February 23, 2006Date of Patent: May 25, 2010Inventors: William F. McKay, Scott D. Boden, Neil Beals
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Patent number: 7671014Abstract: A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or reduced-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.Type: GrantFiled: August 14, 2006Date of Patent: March 2, 2010Inventors: Neal Beals, Jeffrey L. Scifert, Scott D. Boden
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Patent number: 7626070Abstract: A reinforced closure anchor includes a fabric layer having an adhesive side, an opposite non-adhesive side, and an outer edge. An anchor member layer having a reinforcing structure, an adhesive side, and an opposite non-adhesive side is disposed on the fabric layer. The anchor member non-adhesive side is adhered to the fabric layer adhesive side. The anchor member is disposed within the outer edge of the fabric layer.Type: GrantFiled: January 29, 2008Date of Patent: December 1, 2009Assignee: Centurion Medical Products CorporationInventor: Donald J. Propp
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Publication number: 20090222039Abstract: Sutures and methods of suturing with a surgical suture having a core made substantially of biological material (such as biopolymers or proteins, for example) and a cover surrounding the core. The section comprising the biological material may be provided adjacent at least a section of suture not comprising biological material. The section comprising the biological material may be provided in the form of strands or a matrix or a spongy material, which may be additionally treated with biological components such as blood, blood fractions or components, platelet-rich plasma, autologous conditioned plasma, bone marrow aspirate, growth factors, antiseptics, and antibiotics, among others.Type: ApplicationFiled: March 3, 2009Publication date: September 3, 2009Inventors: Peter J. Dreyfuss, Tara L. Schaneville
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Publication number: 20090163951Abstract: The present invention relates to implantable medical devices that include at least one suture attached to a device component, the suture including a naturally derived collagenous material. The present invention is also directed to sutures per se including filaments incorporating naturally derived collagenous material. The naturally derived collagenous material may be an extracellular matrix (ECM) material.Type: ApplicationFiled: December 11, 2008Publication date: June 25, 2009Inventors: Sara Simmons, Don Patterson, Shyam SV Kuppurathanam
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Publication number: 20080051834Abstract: A high strength surgical suture formed of ultrahigh molecular weight polyethylene (UHMWPE) yarns, the suture being coated with native or denatured collagen. The braided jacket surrounds a core formed of twisted yarns of ultrahigh molecular weight polyethylene. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.Type: ApplicationFiled: August 27, 2007Publication date: February 28, 2008Inventors: Augustus D. Mazzocca, MaryBeth McCarthy
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Patent number: 7070858Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.Type: GrantFiled: July 30, 2003Date of Patent: July 4, 2006Assignee: Poly Med IncInventors: Shalaby W. Shalaby, Torbjorn Mathisen
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Patent number: 7026437Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.Type: GrantFiled: July 30, 2003Date of Patent: April 11, 2006Assignee: Poly-Med, INCInventors: Shalaby W. Shalaby, Dan Åkerfeldt, Fredrik Preiniz, Per Egnelöv, Torbjörn Mathisen
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Patent number: 7001410Abstract: Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.Type: GrantFiled: March 27, 2003Date of Patent: February 21, 2006Assignee: Biopsy Sciences, LLCInventors: John S. Fisher, Frederick Ahari, Lucjan J. J. Hronowski
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Patent number: 6977231Abstract: A suturable adhesion-preventing membrane has high suture strength, good biocompatibility, decomposition and absorption in a living body, sufficient adhesion-preventing effect, and desirable guided tissue regeneration. The membrane is composed of at least one non-woven fabric layer made of collagen fibers, or a laminated membranous substance consisting of at least one non-woven fabric layer made of collagen fibers and at least one sponge layer made of collagen, and a coating layer of gelatin or hyaluronic acid on the surface or surfaces of the above membrane. Preferably, the membrane comprises one to six compressed cross-linked collagen non-woven fabric layers wherein a layer has a fibers having a fiber diameter of 0.05 mm to 1.0 mm, a bulk density of 5.0×10?4 to 5 g/cm3 and a thickness of 0.1 mm to 50 mm, and a coating layer containing gelatin or hyaluronic acid and having a thickness of 0.05 mm to 20 mm, wherein the coating layer covers one or both sides or a part or whole of the surface of the membrane.Type: GrantFiled: January 21, 2000Date of Patent: December 20, 2005Assignee: Nipro CorporationInventor: Kazuhisa Matsuda
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Patent number: 6794485Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.Type: GrantFiled: October 31, 2002Date of Patent: September 21, 2004Assignee: Poly-Med, Inc.Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
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Publication number: 20040162580Abstract: Sutures fabricated from and/or coated with compositions including water-soluble glass are described herein. Pledgets containing water-soluble glass within the interstices of the pledget and/or coated with compositions including water-soluble glass are also described herein. The water-soluble glass optionally includes a therapeutic agent, e.g., silver to promote wound repair.Type: ApplicationFiled: February 7, 2003Publication date: August 19, 2004Inventor: Matthew Hain
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Patent number: 6773699Abstract: Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 80 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films which are used to encapsulate structural components such as a cojoinal network or mesh. The resultant patch which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions.Type: GrantFiled: October 9, 2001Date of Patent: August 10, 2004Assignee: Tissue Adhesive Technologies, Inc.Inventors: Barbara A. Soltz, Dale P. DeVore, Braden P. DeVore, Robert Soltz, Michael A. Soltz
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Publication number: 20030026787Abstract: Described are medical devices which are or can be used to form tubular medical devices, and related methods. Preferred devices include tubular grafts of biomaterial having lumen walls which present no seam edge that traverses the entire length of the lumen, illustratively including devices having lumen walls which have a discontinuous seam presenting multiple seam edges. Such a device may include a tubular structure formed by inserting a plurality of extensions of a biomaterial sheet through a plurality of corresponding apertures of the sheet.Type: ApplicationFiled: February 6, 2002Publication date: February 6, 2003Inventors: Neal E. Fearnot, Michael C. Hiles
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Patent number: 6183499Abstract: We have discovered a surgical filament suitable for use as a suture or ligature that comprises a multifilament core having a plurality of filaments that are oriented having an external surface and internal interstices; and an outer coating that bonded to the external surface of the core but does not penetrate into the internal interstices of the core and a process for making these sutures.Type: GrantFiled: August 4, 1999Date of Patent: February 6, 2001Assignee: Ethicon, Inc.Inventors: Jerome A. Fischer, Howard Scalzo, Jianguo J. Zhou
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Patent number: 5954748Abstract: A catgut suture includes a cross linked gelatin coating which is substantially insoluble in tubing or storage solution. The gelatin coating is formed by immersing the gut suture in aqueous gelatin solution, fixing the gelatin in a solution of cross linking agent such as glutaraldehyde, buffering the coating, then drying the suture at a temperature of at least about 50.degree. C.Type: GrantFiled: July 15, 1996Date of Patent: September 21, 1999Assignee: United States Surgical CorporationInventor: Nagabhushanam Totakura
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Patent number: 5931165Abstract: Gelatin film compositions are useful for immobilization over tissue, usually by the application of energy to the films. Exemplary films comprise cross-linked and non-cross-linked granular and non-granular gelatin sheets, typically including a plasticizer. The gelatin films are dry, thin, and preferably meet certain pliability, elasticity, melting temperature, and other criteria. Methods are described for producing these films from collagen. Methods are further described for applying these films to tissue.Type: GrantFiled: February 6, 1997Date of Patent: August 3, 1999Assignee: Fusion Medical Technologies, Inc.Inventors: Cary J. Reich, Donald G. Wallace, Greg Dapper
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Patent number: 5925065Abstract: A coated gut suture is prepared by applying a moisture-retaining substance to the gut suture, followed by coating the suture with a synthetic bioabsorbable polymer. A particularly useful moisture-retaining substance is glycerol. The synthetic bioabsorbable polymer contains a epsilon-caprolactone as the major constituent. The gut suture can be packed in the absence of conventional tubing fluid while retaining flexibility, pliability, and resistance to fray.Type: GrantFiled: November 5, 1996Date of Patent: July 20, 1999Assignee: United States Surgical CorporationInventors: Nagabhushanam Totakura, Mark S. Roby
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Patent number: 5919473Abstract: An analgesic agent delivery system and method of treating postoperative pain comprising an analgesic agent such as morphine and an extended-release drug delivery device. The device may be placed in the vicinity of a wound and then provide an extended-release of the analgesic agent over a period of time, thereby controlling the pain emanating from the wound.Type: GrantFiled: May 12, 1997Date of Patent: July 6, 1999Inventor: George F. Elkhoury
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Patent number: 5725522Abstract: Methods and systems for endoscopic suturing of biological tissue are disclosed. Endoscopic instruments are described which serve to position a suture material at an anastomotic site and deliver laser radiation to the suture material to effect fusion. The suture material includes a structure adapted for positioning at an anastomotic site and has at least a portion of the structure formed by a photoreactive crosslinking agent, such that upon irradiation of the structure the crosslinking agent adheres to the biological material. In one embodiment, the suture material can also include a high tensile strength element which is coated with a laser activatable crosslinking agent or glue. Upon activation, the suture material creates a desired closure or joinder of the biological material and is left in place while the endoscope is advanced to another target site or removed.Type: GrantFiled: June 7, 1995Date of Patent: March 10, 1998Assignee: Rare Earth Medical, Inc.Inventor: Edward L. Sinofsky
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Patent number: 5690675Abstract: Wounds in lung tissue are closed in a two step method consisting essentially of applying fasteners to a region adjacent to the wound, wherein the fasteners may cause penetrations. The fasteners are present in a preformed layer of collagen, fibrin, fibrinogen, elastin, albumin, or a combination thereof, and energy is applied to the region to fuse the material to the tissue and seal perforations in the tissue.Type: GrantFiled: June 7, 1995Date of Patent: November 25, 1997Assignee: Fusion Medical Technologies, Inc.Inventors: Philip N. Sawyer, Philip M. Sawyer, Cary J. Reich
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Patent number: 5618312Abstract: Disclosed are a medical material and a production process thereof. The medical material has a membrane configuration and is produced by impregnating a membranous material with collagen or gelatin and then physically or chemically cross-linking protein molecules of the membranous material. The membranous material is essentially acellular compact layer of a biogenic connective tissue. The medical material may further be processed into other forms such as threads, braids, tubes and hoses and is useful in surgery. The medical material has a strength sufficient to be useful for surgically stitching wounds either manually or mechanically.Type: GrantFiled: April 12, 1996Date of Patent: April 8, 1997Assignee: Bio-Engineering Laboratories, Ltd.Inventors: Tooru Yui, Tokuzo Nakagawa, Kazuo Kondoh
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Patent number: 5618313Abstract: Absorbable copolymers are fabricated from a predominant component of dioxanone randomly copolymerized with minor amounts of other bioabsorbable monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures.Type: GrantFiled: October 11, 1994Date of Patent: April 8, 1997Assignee: United States Surgical CorporationInventors: Mark S. Roby, Donald S. Kaplan, Cheng-Kung Liu, Steven L. Bennett
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Patent number: 5614587Abstract: Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant.Type: GrantFiled: June 7, 1995Date of Patent: March 25, 1997Assignee: Collagen CorporationInventors: Woonza M. Rhee, Prema R. Rao, George H. Chu, Frank A. DeLustro, Carol F. H. Harner, Naomi Sakai, Jacqueline A. Schroeder
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Patent number: 5584857Abstract: A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C.sub.2 -C.sub.4 alcohol and a lubricant of fatty acids, fatty acid alcohols and/or triglycerides of fatty acids. Gut sutures coated with the coating composition may be stored or packaged in the tubing fluid to provide sutures with improved flexibility, pliability, run-down performance and superior resistance to fraying and breaking.Type: GrantFiled: November 14, 1994Date of Patent: December 17, 1996Assignee: United States Surgical CorporationInventors: Nagabhushanam Totakura, Shalaby W. Shalaby, Lyudmila Kokish