Abstract: This disclosure relates to methods of surgical tissue reconstruction, such as for joint or ligament repair, and associated surgical constructs.

Abstract: Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.

Abstract: An all-suture anchor for generating bone compression and increasing interference fixation. The all-suture anchor includes a fibrous construct which is movable between a pre-deployment configuration and a deployed configuration. The fibrous construct has a first density. The all-suture anchor also includes a monofilament woven through the fibrous construct. The monofilament has a second density, which is different than the first density. The contrasting densities (i.e., irregularities) aids in the “locking” ability of the all-suture anchor by greater purchase in hard and soft bone. The all-suture anchor can have a variety of textures, barbs, and rigidities that aid in creating irregularities within the bone surface for more secure fixation.

Abstract: A display device is able to be operated with a first state and a second state, and the display device includes a substrate and a plurality of light emitting units. When the display device is extended along a stretched direction from the first state to the second state, the substrate has a first width in the first state and a second width in the second state. The second width is greater than the first width. The plurality of light emitting units are disposed on the substrate, and the plurality of light emitting units can be in a mode of ON or in a mode of OFF. The light emitting units being in the mode of ON are in a number of N1 while in the first state. The light emitting units being in the mode of ON are in a number of N3 while in the second state, and N3>N1.

Abstract: A suture according to an embodiment of the present disclosure includes a first barb portion, a second barb portion, and a center portion which connects the first barb portion and the second barb portion to each other. Each of end portions of the first barb portion and the second barb portion may be formed so as to face the center portion, and a hole portion including a plurality of holes may be formed in at least one of the first barb portion, the second barb portion, and the center portion. The suture may show an excellent recovery and a lifting effect to be semi-permanently maintained and may have an excellent strength.

Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.

Abstract: Disclosed is a medical material manufactured using collagen and a method of manufacturing the same. The method includes (1) preparing collagen using distilled water as a solvent, (2) filling a syringe with the prepared collagen and then spinning the collagen through a syringe needle, (3) immediately immersing the spun collagen in a cross-linking solution, which is a mixture including therein a hyperosmotic agent and a cross-linking agent mixed with each other, (4) removing and then washing the collagen after cross-linking is completed, and (5) removing and then drying the collagen after the washing is completed. When the collagen is spun and processed into the form of a thread and the spun thread is then cross-linked, the cross-linked collagen thread has increased strength compared to before cross-linking, and the shape thereof is retained in an aqueous solution.

Abstract: An anchor is provided for placement in or against tissue. The anchor includes a flat fibrous construct having a first end and a second end; and a filament having a first end and a second end passing through the fibrous construct in two locations including a first passing location nearest a first end of the fibrous construct, a second passing location nearest a second end of the fibrous construct, the filament remaining free to slide through the first passing location and the second passing location such that the filament can be removed from the flat fibrous construct from the first end of the fibrous construct and the second end of the fibrous construct. The anchor can be inserted into a bone hole and deployed.

Abstract: Cartilage support implants for nasal valve support and delivery systems are described. The cartilage support implant can include one or more elongate bodies comprising one or more anchors. The cartilage support implant can be designed to be a permanent implant extending along the midline of a patient's nose, from the nasal bone to the lower lateral cartilage. Methods of placing the cartilage support implant and retrieving the cartilage support implant are also described.

Abstract: The invention relates to an arrangement (1) comprising at least one structural element (2) made of an absorbable material with an antibacterial effect with a mount, which possesses an aspect ratio greater than 10 and whereat the material is a rapidly corroding magnesium alloy. The invention further relates to a mount (10) with an arrangement (1) carried by the mount (10) comprising at least one structural element (2) made of an absorbable material with an antibacterial effect.

Abstract: Apparatus for securing an object to bone, the apparatus including an anchor assembly comprising an anchor and an actuation element extending from the anchor, wherein applying a force to the actuation element when the anchor is disposed in a hole formed in a bone secures the anchor to the bone; and an inserter for deploying the anchor assembly in a hole formed in a bone, the inserter including a shaft for releasably engaging the anchor; and a force delivery mechanism mounted to the shaft and connected to the actuation element, the force delivery mechanism being constructed so as to receive an input force from an external source and to selectively apply an output force to the actuation element, with the force delivery mechanism being constructed so that the magnitude of the output force is limited regardless of the magnitude of the input force.

Abstract: A suture for lifting is disclosed. The suture comprises: a medical fiber yarn; fixing parts formed at one side of the fiber yarn and fixable to the skin; and anchor parts protruding on an outer circumference of the fixing parts, wherein the anchor parts are integrally formed with the fiber yarn by a double injection.

Abstract: Multi-filament microcables are used in place of the traditional monofilament wires as the constituent elements of a woven or braided band. This enhances the function and manufacturability of such bands for various applications, such as orthopaedic applications including sternotomy closures.

Abstract: Devices, systems, and methods to improve both the reliability of soft tissue repair procedures and the speed at which the procedures are completed are provided. The devices and systems include one or more tissue augmentation constructs, which include constructs that are configured to increase a footprint across which suture applied force to tissue when the suture is tied down onto the tissue. The tissue augmentation constructs can be quickly and easily associated with the repair suture, and can be useful in many different tissue repair procedures that are disclosed in the application. Tissue augmentation constructs can include various blocks and scaffolds, among other formations. The present disclosure includes, among other disclosures, methods for using tissue augmentation scaffolds, including folding scaffolds, and descriptions and methods associated with extra-wide tissue augmentation blocks.

Abstract: A mechanical suture fastener includes a crimpable sleeve defining a channel therein. The crimpable sleeve also has a sleeve length, a channel diameter, and a sleeve length to channel diameter ratio of at least 4.0. The mechanical suture fastener also includes a flange joined to the crimpable sleeve on a distal end of the sleeve. The flange further includes a distal opening which is in communication with a proximal opening defined by the crimpable sleeve. The mechanical suture fastener also includes an inner flange radius of at least 0.007 inches.

Abstract: Systems and methods for driving a flexible medical instrument to a target in an anatomical space with robotic assistance are described herein. The flexible instrument may have a tracking sensor embedded therein. An associated robotic control system may be provided, which is configured to register the flexible instrument to an anatomical image using data from the tracking sensor and identify one or more movements suitable for navigating the instrument towards an identified target. In some embodiments, the robotic control system drives or assists in driving the flexible instrument to the target.

Abstract: Suture constructs and methods for soft tissue to bone repairs. The suture construct is a soft, suture-based anchor which is self-cinching and has a specific, accordion-type configuration (i.e., with the ability to fold from a first, extended position to a second, folded or compressed position). The suture-based anchor may be formed essentially of a flexible material such as a high strength surgical suture, suture chain, or suture.

Abstract: Methods, systems, and devices for changing cross-sectional sizes and/or shapes of flat braided sutures and the resulting constructs are disclosed. The flat braided sutures can have a textile first cross-sectional shape that can be changed to a textile second cross-sectional shape. The systems can have a heater and a die. The flat braided sutures can be movable through the heater and the die. When the flat braided sutures are in the heater, the flat braided sutures can be heatable from a textile first temperature to a textile second temperature greater than the textile first temperature. When the flat braided sutures are at the textile second temperature, the textile first cross-sectional shape can be changeable to the textile second cross-sectional shape.

Abstract: A tissue closure device to assist in retrieving a suture during a suturing procedure, the device including an elongated body having a proximal end, a distal end, and a lumen extending axially through the elongated body. The device further including an actuator rod at least partially extending through the lumen of the elongated body to actuate a plurality of wings and a plurality of shields attached to a distal end of the elongated body. The elongated body including at least one needle guide lumen with an opening an exit, the at least one needle guide lumen traversing the elongated body at an angle with respect to a central axis of the elongated body to guide a suture grasper to an enclosed suture retrieval cavity.

Abstract: Anchor delivery systems include anchors having a generally cylindrical body with a rail on top for positioning within a delivery device slot. The rail incorporates a side-bulge as a retaining feature which axially extends along a majority of the length of the rail. The bulge interferes with a corresponding hourglass cutout in the delivery device slot to prevent the anchor from stripping out of the delivery device when the delivery device is retracted through tissue. The anchors are symmetrical along a length and width to facilitate loading within the delivery device. The distal portion of the delivery device includes a series of distally-extending barbs that intentionally change the penetration force required to push the device tip through tissue.

Abstract: The present invention relates to a method of preparing a suture anchor using a suture and a prepared suture anchor. A knitting member (100) cut at a predetermined width and length while having a plurality of knots (10a) is inserted into a hole 1a of a bone 1 using an anchor inserting device 200, and a second suture 20 provided between one knot 10a of the plurality of knots and another knot 10a thereof is pulled rearwards, and thus the knitting member (100) is deformed from a long rod shape to a lump shape the bone 1. Accordingly, the knitting member (100) has a volume larger than a diameter of the hole 1a, and the knitting member (100) deformed into the lump shape is configured not to be removed from the hole 1a of the bone 1 even when the second suture 20 is further pulled in a rear direction.

Abstract: A facial invasive tissue treatment method includes the following procedures. Mark five to ten facelift suture path lines on each half face of a user in a predetermined pattern according to the facial condition of the user, wherein each facelift suture path line has an upper segment, a lower segment, and an insertion mark between the upper segment and the lower segment. After sterilization of the user's face, perform anesthesia at portions of the user's face where the needles inserting in and penetrating by injecting anesthetics at least at the insertion marks and the outlet marks of the facelift suture path lines marked on both half faces of the user. Thereafter, it is preferred to perform another sterilization to the user's face. Implant five to ten invasive sutures in the subcutaneous tissue layer of both half faces of the user along and underlying the facelift suture path lines marked thereon respectively.

Abstract: A method of effecting a tendon repair in a patient comprising providing a suture tape, using the suture tape to connect tendon tissue to bone of the patient such that the suture tape lays flat on the tendon, and permitting ingrowth of the tendon tissue into the suture tape as the absorbable fibers are absorbed into the patient's tissue. The suture tape is a flat braid of elastic, absorbable fibers and high strength fibers, the tape being at least 1 mm wide and 2 cm long, and less than 1 mm high. The suture tape includes at least 4 absorbable fibers and at least 4 high strength fibers. Further, the suture tape is capable of being stretched at least 10% from its shortest length to the length at which it breaks and is capable of withstanding a load of at least 260 Newtons before breaking.

Abstract: The present invention relates to a surgical thread including at least a first portion extending longitudinally and comprising a central thread covered with a sheath. The sheath includes fastening means each including at least one conical barb. The present invention also relates to a medical device including such a surgical thread and a surgical needle.

Abstract: A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and methods for molecular scale healing are provided. The composition can resolve structural defects by a bio-mimetic close-then heal process. In use, the shape memory polymer can provide molecular scale healing in a structural defect. The methods for molecular scale healing can include heating a composition including a thermoplastic such as fibers, particles or spheres to a level at or above the thermoplastic's melting point, then cooling of the composition below the melting temperature of the thermoplastic. The compositions have the ability to close macroscopic defects repeatedly even if another wound/damage occurs in a previously healed/repaired area.

Abstract: Methods and kits are provided to treat scapho-lunate ligament tears, which involve stabilization of the scaphoid and lunate both dorsally and volarly. The treatments can be performed through open, mini-open or arthroscopic procedures, as an intra-capsular or extra-capsular repair and stabilization procedure. The treatment procedures involve the use of sutures or wires to fix the relative orientations of the scaphoid and lunate, and the optional use of bone anchors or other bone attachment devices to create a capsulodesis between the lunate and scaphoid, or other bones, to lift the scaphoid into the desired position. Localization of the entry point of the sutures or wires into the bones are used to improve positioning of the bone anchors, sutures and wires.

Abstract: In one embodiment of the present disclosure, an apparatus for securing a first object to a second object, including a deformable anchor body, a working suture connected to the anchor body, the working suture including a pre-formed knot, and a repair suture connected to the first object, wherein, with the anchor body connected to the second object and at least one of the anchor body and the working suture connected to the repair suture, the anchor body is adapted to secure within the second object and the working suture and repair suture are adapted to secure to the anchor body to secure the first object to the second object.

Abstract: A bone graft retention plate for implantation into a human glenoid and provides stabilization and compression of bony graft material is disclosed. The plate includes channels or apertures for suture or polymer retention cerclage that exhibit curved, smooth surfaces within the plate to allow the retention cerclage to pass through the plate while limiting friction and thus protecting the integrity of the retention means. The plate also includes surface features, such as spikes and posts, to provide further stabilization and implantation positioning. The plate features result in the distribution of forces across the surface area of a bone graft and achieve satisfactory compression of the bone graft against the glenoid without using fixation screws. An associated implantation technique uses a cerclage of suture or tape to bind the implant within the glenoid and may be employed in both open and arthroscopic surgical procedures.

Abstract: Disclosed is a medical thread insertion instrument including: a medical thread having an outer surface thereof on which barbs are formed; a needle part having a cavity therein so that the medical thread is able to be inserted, the needle part including a needle having a predetermined length (L1); and a tube part having a cavity therein so that the needle is able to be inserted, the tube part being inserted into an inner side of the skin and including a tube having a length (L2) shorter than the length (L1) of the needle.

Abstract: An adjustable construct for fixation of a tendon or ligament graft in a tunnel. The construct comprises a flexible, adjustable loop connected to tissue (for example, graft, ligament or tendon). The adjustable loop may be integrated with an additional tissue supporting device (for example, a wedge or a plug). The tissue is secured within a bone socket/tunnel by adjusting the length of the flexible adjustable loop.

Abstract: An all-suture anchor for attaching soft tissue to bone while creating an interference fit within a bone hole, and a deployment device for the all-suture anchor. The all-suture anchor includes an anchor body having first and second ends. The second end is folded toward the first end, creating a looped distal end of the anchor body, while the first and second ends of the anchor body form a proximal end. The anchor body is composed of a first material having a first density. A passing filament, of a second (different) density, is woven through the anchor body at passing locations such that a pair of free ends of the passing filament extends from the proximal end of the anchor body. The all-suture anchor additionally includes a binding filament bound axially at the proximal end of the anchor body around the first end and the second end of the anchor body.

Abstract: A suture implant can include one or more suture cords having: a splice; a first free end extending from a first end of the at least one splice; an adjustable first loop extending from a second end of the at least one splice; a second free end extending from a first end of the at least one splice; a needled second loop having a cord portion extending from the first end of the at least one splice; a needle on the needled second loop; and an adjustable third loop extending from a second end of the at least one splice that has the second free end extending from the first end, wherein the second free end is connected to the adjustable third loop, wherein the adjustable first loop and adjustable third loop are interconnected and looped around each other.

Abstract: A wound closure device can be provided as described herein. In an example, the wound closure device includes a first suture segment having a first suture configuration and a second suture segment having a second suture configuration. The first and second suture configurations can be different from each other. For example, the first suture configuration can includes a first set of characteristics such as barbed or non-barbed, barb sizes, filament sizes, colors, materials, and/or the like and the second suture configuration can include a second set of characteristics such as barbed or non-barbed, barb sizes, filament sizes, colors, materials and/or the like that can be different from the first set of characteristics. The wound closure device can further include connecting section configured to provide a transition from the first suture segment to the second suture segment.

Abstract: Implantable materials for use with end effectors like surgical stapling devices, and methods for using the same, are generally provided. In some embodiments, adjunct materials for use with surgical staplers are provided. For example, a kit for stapling tissue is provided that can include a surgical stapler having an end effector. The end effector can have first and second jaws. The kit can include an adjunct material having hydrophobic surface regions and hydrophilic surface regions and the adjunct material can be configured to mate to at least one of the jaws of the end effector. Other implants, devices, and methods for surgical stapling are also provided.

Abstract: The present disclosure is directed toward composite materials comprising high aspect ratio habits of drug crystals which can be partially or fully extending into a substrate, and additionally, can be projecting from a substrate at an angle of about 20° to about 90°. The present disclosure is directed toward medical devices, such as medical balloons, comprising said composite and methods of using and making the same. The described composite can be used for the local treatment of vascular disease. The present disclosure is also directed toward paclitaxel crystals with a hollow acicular habit.

Abstract: Suture constructs and methods for soft tissue to bone repairs. The suture construct is a soft, suture-based anchor which is self-cinching and has a specific, accordion-type configuration (i.e., with the ability to fold from a first, extended position to a second, folded or compressed position). The suture-based anchor may be formed essentially of a flexible material such as a high strength surgical suture, suture chain, or suture.

Abstract: The present invention relates to a suture which is firmly maintained and fixed to an operation site to stably sustain suturing or lifting effects for a long time. More specifically, the present invention provides a suture having a conic or pyramidal shape with a cut top, wherein a suture supporter comprising a communication hole penetrating the both ends is provided at one end. The suture support can have one or more portions which are cut vertically from a lower end at a lower end portion having a larger diameter between the both ends, or a part of the lower end can be removed so as to form one or more gaps formed from the end at a wall of the end portion.

Abstract: Embodiments of the invention include methods and devices for coupling to a suture with a suture anchor. The suture anchor may include a cavity in which a length of suture may be drawn prior to insertion and from which that length of suture may be drawn out as the suture anchor is implanted. Therefore, in some embodiments, suture may be drawn out of the cavity from the length of suture rather than from working portions of the suture that extend outwardly from the tissue in which the suture anchor is being implanted.

Abstract: A suture anchor assembly, adapted to be attached to a bone, that includes an anchor, which has an undeployed state in which it is soft and flexible, and which can be deployed into a deployed state which is compacted and hard, relative to the undeployed state, and defining a hold region, where the anchor is optimally held as the anchor is deployed. Also, one or more deployment strands are engaged into the anchor and extend out of the anchor, and wherein, when the anchor is in the undeployed state, holding the anchor at the hold region and pulling on the deployment strands compacts the anchor into the deployed state. Accordingly, the anchor can be introduced into a hole in bone and held in place at the hold region, as it is transformed into the deployed state by pulling on the deployment strands, thereby anchoring the anchor in the hole.

Abstract: Systems and methods of placing one or more suture loops into tissue, such as the base of the tongue, are described. A system can include a variable-thickness suspension line for suspending tissue, including a suture having a first thickness dimension; an elastomer surrounding a portion of the suture and defining a central segment of the suspension line having a second thickness dimension greater than the first thickness dimension, and at least one transition zone extending from the central segment of the suspension line to a lateral end of the suspension line, the transition zones having a thickness dimension that tapers from the second thickness dimension to the first thickness dimension.

Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.

Abstract: Cauls and methods of using the same are provided. The caul includes a reinforcement material having one or more elastic fibers and a polymer having one or more shape memory polymers. The caul is operable to transition from a rigid state to an elastomeric state and from an elastomeric state to a rigid state in response to stimuli. Methods of using cauls to produce composite articles involve positioning one or more fiber layers between a caul and a cure mold surface when the caul is in a rigid state. The fiber layers, caul, and cure mold surface may be covered with a sealed barrier and a pressure gradient may be applied. Before, after, or before and after performing the vacuum the fiber layers may be impregnated with resin. The fiber layers may be cured, which may provide a stimulus to transition the caul from a rigid to an elastomeric state.

Abstract: A tissue marking device enables the deployment of a hook to mark a location within a breast. The deployment is performed by inserting a needle in tissue until it arrives at a target location and pressing on the end of a rod that embeds the hook in the tissue. A thread is attached to the hook and is left exposed to facilitate locating the hook.

Abstract: A graft suspension device for suspending a ligament in a bone hole having a first loop and a second loop suspending from an 8-hole anchor, and a cradle at the opposite end of the loops to the anchor. The loose ends of the suture are routed through holes in the anchor separate from the loops and are joined together to form a single tail. A finger loop allows a surgeon to adjust the distance of the cradle from the anchor with the cradle staying centered with respect to the anchor as the distance is adjusted.

Abstract: A link (1) for connecting two loops of a flexible tension-carrying construct (2, 2a). It solves the problem of providing effective means to connect two anchor points (7, 7a), typically on bones articulating at a joint by the flexible tension-carrying construct.

Abstract: The present disclosure describes tissue gripping devices, systems, and methods for gripping mitral valve tissue during treatment of a mitral valve and while a tissue fixation device is implanted in the mitral valve. The tissue gripping device includes a flexible member and one or more tissue gripping members coupled to one or more arms of the flexible member. The flexible member is formed from a shape-memory material, such as nitinol, and the tissue gripping member(s) are formed from a material that is more rigid than the shape-memory material. The tissue gripping member(s) are attached to the flexible member by threading or looping suture lines around and/or through the tissue gripping member(s) and the flexible member and/or by applying a cover material to the tissue gripping device to hold the tissue gripping member(s) against the flexible member.

Abstract: A suture assembly including a first suture having a generally O-shaped configuration having a first arm, a second arm, a first bridge connecting the first arm to the second arm, and a second bridge connecting the first arm to the second arm. The first bridge opposes the second bridge so that the first suture includes a closed loop. A second suture having a first arm, a second arm and a bridge connecting the first arm to the second arm. The first arm of the second suture is wrapped around the first arm of the first suture in a first direction, and the second arm of the second suture is wrapped around the second arm of the first suture in a second, opposite direction. The suture assembly is capable of assuming (i) a longitudinally-extended, radially-contracted first configuration, and (ii) a longitudinally-contracted, radially-expanded second configuration.

Abstract: An anchoring system can use an implant delivery device to deploy an implant into a pre-drilled bore, to secure one or more sutures between a threaded outer surface of an implant body and a wall of the bore. The implant delivery device can controllably rotate the implant about its longitudinal axis. The implant can further include a distal member positioned distal to the implant body and freely rotatable about the longitudinal axis. The implant delivery device can include a finger extending distally from a distal end of an inner shaft. The implant delivery device can controllably translate a wire between a distally extended position, at which the wire can form a closed loop with the finger and a distal end of the inner shaft, and a proximally retracted position, at which the wire can be at least partially retracted into the distal end of the inner shaft.

Abstract: A barbed suture is provided. The barbed suture includes an elongate body and at least one barb extending from the elongate body. The elongate body defines a recess adjacent the at least one barb. Also provided is a method of making a barbed suture. The method includes the steps of providing a suture nest and a punch apparatus configured for operable engagement with the suture nest, loading a suture through the suture nest, engaging the punch apparatus with the suture nest, and disengaging the punch apparatus with the suture nest.

Abstract: A device for ligament reconstruction includes an elongated body and a hook or loop at each end for receiving a ligament reconstruction member such as an allograft or autograft tendon. The ligament reconstruction member is positioned within a hole that is drilled into a bone, or which is provided within a prosthetic joint. A central portion of a ligament reconstruction member is passed through each end of the device. The ends of the ligament reconstruction members are then fastened to the opposing bone forming the joint.