Abstract: The invention provides surgical systems and methods for ablating heart tissue within the interior and/or exterior of the heart. A plurality of probes is provided with each probe configured for introduction into the chest for engaging the heart. Each probe includes an elongated shaft having an elongated ablating surface of a predetermined shape. The elongated shaft and the elongated ablating surface of each probe are configured to ablate a portion of the heart. A sealing device affixed to the heart tissue forms a hemostatic seal between the probe and the penetration in the heart to inhibit blood loss therethrough.

Abstract: Methods, systems, and computer program products measure electrical activity of the cardiac tissue proximate the lesion site during an ablation treatment, and then compare the measurements to determine whether the lesion is clinically efficacious so as to be able to block myocardial propagation. The methods can include obtaining the measurements and performing the ablation therapy while the subject is experiencing atrial fibrillation and may measure the standard deviation of the electrogram signal.

Abstract: The invention relates to a method for producing medical electrodes, in particular, neutral electrodes. According to the inventive method, a web-shaped laminate, consisting of a non-conductive intermediate support (C) and a conductive layer (A) is coated on the side of said conductive layer with an electrically conductive, adhesive gel (E). The laminate-gel combination is formed to a specific contour, preferably punched out, before being fixed to a carrier (H) by the side opposite to the gel (E). The conductive layer is applied to the web-shaped intermediate support (C) during the production of the laminate, preferably having been previously punched out, as panels which do not cover the entire web-shaped intermediate support (C).

Abstract: Distal catheter assemblies, catheters, and methods for minimizing damage to heat and/or magnetically sensitive components are provided. A distal catheter assembly comprises a housing having a cavity and a proximal mounting member. The sensitive component, e.g., a magnetic sensor, is mounted within the cavity of the housing, and another component, e.g., a steering assembly or RF wire, is mounted to the proximal mounting member. If the proximal mounting member is hollow, it may have a window to provide access to the inner surface of the proximal mounting member to facilitate mounting of the other component. The proximal mounting member extends proximally from the sensitive component, thereby minimizing any adverse effects on the sensitive component that may otherwise result from mounting the other component in close proximity to the sensitive component. In the preferred embodiment, the housing forms a cap-shaped head and a cylindrical neck section, with the head forming an ablation electrode.

Abstract: Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to “model” collagenous tissues of the LES by shrinking collagen fibers therein. Typically, an Rf source is connected to at least one conductive electrode that may be operated in a mono-polar or bi-polar fashion. A sensor array of individual sensors is provided in the working end.

Abstract: The present invention discloses a transplantation device with a longitudinal groove having a wider slot as a loading area and a narrower slot as a retaining area further developing into a tapered sharpened wedge with depth control performing desired multiple functions of a dissector, site creator, stopper, spiral cavity maker, stretcher, separator and slider capable of harvesting and planting. The device functions without electricity, suction or spring assistance having the advantages of being multifunctional, small, light weight, handy, autoclavable, sterilisable, disposable, having minimum joints and moving parts yet easily manufacturability in wide range of sizes from various materials, with capability to harvest and plant wide range of plant able materials into diverse substrates at enhanced plantation speeds maintaining follicular integrity resulting in better yield.

Abstract: Methods and apparatus employed in surgery involving making precise incisions in vessels of the body, particularly cardiac blood vessels in coronary revascularization procedures conducted on the stopped or beating heart are disclosed. Such incisions are created by applying an elongated electrosurgical cutting electrode to the outer surface of the vessel wall in substantially parallel alignment with the body vessel axis, the elongated electrosurgical cutting electrode having a predetermined cutting electrode length exceeding the cutting electrode width. RF energy is applied between the electrosurgical cutting electrode and the ground electrode at an energy level and for a duration sufficient to cut an elongated slit through the vessel wall where the elongated electrosurgical cutting electrode is applied to the surface of the vessel wall.

Abstract: An electrosurgical generator apparatus controls a variable output signal to electrodes. The generator apparatus operates in a cut mode, a coagulation mode or a stimulate mode. The generator apparatus comprises a DC power supply that provides regulated low voltage and high voltage outputs and a radio frequency (RF) waveform generator circuit that provides pulse duration modulation (PDM) of a carrier signal. The carrier signal directly affects the variable output signal to the electrodes. A control circuit controls a variable output signal to electrodes used in electrosurgical procedures. The control circuit comprises a DC power supply circuit that provides regulated low voltage and high voltage outputs and an RF waveform generator circuit that provides pulse duration modulation of a carrier signal. The carrier signal directly affects the variable output signal to the electrodes.

Abstract: Methods and apparatus for selectively applying electrical energy to a target location within a patient's body, particularly including tissue in the spine. In a method of the invention high frequency (RF) electrical energy is applied to one or more active electrodes on an electrosurgical probe in the presence of an electrically conductive fluid to remove, contract or otherwise modify the structure of tissue targeted for treatment. In one aspect, a dura mater and spinal cord are insulated from the electrical energy by an insulator positioned on a non-active side of the probe. In another aspect, a plasma is aggressively formed in the electrically conductive fluid by delivering a conductive fluid to a distal end portion of the probe and aspirating the fluid from a location proximal of the return electrode.

Abstract: To provide a novel spinal reforming tool that may obtain an extremely high reforming effect only by a simple operation, a pair of reforming projecting portions (3) are provided in parallel with each other on a top portion of a tool body (2) which supports at least an upper half of a human body (1) and with which a back portion of the human body may contact. A reforming groove (4) between the reforming projecting portions (3) is formed in a longitudinal direction of a spine (5) of the back portion of the human body (1) supported on the tool body (2). The reforming projecting portions (3) are slanted in either one of the longitudinal direction, and a drop portion (6) dropping at an abrupt angle is provided at an end portion of the reforming projecting portions (3) on a slanted upward side.

Abstract: Systems and methods are provided for removing adipose or fatty tissue underlying a patient's epidermis is disclosed (e.g., liposuction, abdominoplasty, and the like). The method includes positioning one or more active electrode(s) and one or more return electrode(s) in close proximity to a target region of fatty tissue. A high frequency voltage difference is applied between the active and return electrodes, and the fatty tissue or fragments of the fatty tissue are aspirated from the target region. The high frequency voltage either softens the fatty tissue or completely removes at least a portion of the tissue. In both embodiments, the remaining fatty tissue is more readily detached from the adjacent tissue in the absence of energy, and less mechanical force is required for removal. The bipolar configuration of the present invention controls the flow of current to the immediate region around the distal end of the probe, which minimizes tissue necrosis and the conduction of current through the patient.

Abstract: Disclosed is an ablation method and apparatus used to close veins for treatment of venous insufficiency disease. The apparatus includes a catheter proportioned for insertion into a vein, a pair of inflatable balloons spaced apart on the catheter body, and an ablation electrode array disposed between the balloons. According to the disclosed method, the catheter is introduced into the vein to be treated and the balloons are distended. Blood is flushed and aspirated from the site between the balloons. RF power is applied to the electrode array, causing scarring of the vessel walls and eventual sealing of the vein.

Abstract: The present invention provides systems and methods for selectively applying electrical energy to a target location within of a patient's body, particularly including tissue in the spine. The present invention applies high frequency (RF) electrical energy to one or more electrode terminals in the presence of electrically conductive fluid to remove, contract or otherwise modify the structure of tissue structures. In one aspect of the invention, a method is provided for treating herniated discs within a patient's spine by applying sufficient electrical energy to the disc tissue to reduce a volume of the disc, thereby relieving pressure on a spinal nerve. In one embodiment, the high frequency voltage is sufficient to ablate a portion of the nucleus pulposis, either the extruded portion outside of the annulus or a portion or all of the pulposis within the annulus.

Abstract: For stopping bleeding at an incensed wound, quickly, with using a medical manipulator system, having a plural number of manipulators therein, the medical manipulator system comprises manipulators, each having an operation tool, respectively. Onto the operation tools is applied current, alternately, from a positive electrode of a bipolar electric power source. Onto the other operation tool is applied current from a negative electrode of the bipolar electric power source. Driving the operation tool cauterizes a portion of an affected portion, thereby stopping bleeding in a wide region.

Abstract: A catheter introduction apparatus provides an optical assembly for emission of laser light energy. In one application, the catheter and the optical assembly are introduced percutaneously, and transseptally advanced to the ostium of a pulmonary vein. An anchoring balloon is expanded to position a mirror near the ostium of the pulmonary vein, such that light energy is reflected and directed circumferentially around the ostium of the pulmonary vein when a laser light source is energized. A circumferential ablation lesion is thereby produced, which effectively blocks electrical propagation between the pulmonary vein and the left atrium.

Abstract: Methods and systems apply biphasic DC signal at various frequencies, durations and/or amplitudes to areas of a cancer patient's body being targeted for preventing or alleviating cancer-therapy side effects. Microcurrent therapy can be provided prior to, during and after procedures used to treat cancer. During microcurrent treatment a biphasic DC signal can be applied from a microcurrent therapy system to an area of the cancer patient's body targeted for microcurrent treatment using at least one electrode. The electrode can be actively manipulated on the treatment area for a predetermined time. The system can provide impedance matching between it and the patient during treatment. A feedback module provides a controller impedance information between the patient and system where a mismatch is used to adjust the system to overcome impedance variations that occur between said system and said patient's body during the predetermined time of treatment.

Abstract: A universally functional biomedical electrode is disclosed, where the electrode has a resistive element that reduces edge effect by a redistribution of current within the electrode and in mammalian tissue contacting the electrode. In one embodiment, the electrode has at its perimeter in one layer the resistive element that provides a cross-sectional area to reduce edge effect regardless of the type of biomedical instrumentation connected thereto. With the construction of other layers suitable for multifunctional electrode usage, this electrode can serve as a single item in inventory at health facilities.

Abstract: An ablation system and a method of its use. The system includes a first elongated ablation component carrying a longitudinally extending mechanism for delivery of ablation energy along its length, and a second elongated ablation component movable relative to the first ablation component. The first and second components are provided with a mechanism mounted to and extending along the first and second components for magnetically attracting the first and second components toward one another along the length of the first mechanism for delivery of ablation energy. Preferably, the second elongated ablation component also carries a longitudinally extending mechanism for delivery of ablation energy along its length.

Abstract: Devices and methods for treating a damaged intervertebral disc to reduce or eliminate associated back pain. The present invention provides disc reinforcement therapy (DRT) which involves implanting one or more reinforcement members in and preferably around the annulus of the disc. The reinforcement members may be used to stabilize the annulus and/or compresses a portion of the annulus so as to reduce a bulge and/or close a fissure.

Abstract: Compositions comprising absorbable implantable vaso-occlusive members are described. Also described are methods of making and using these absorbable vaso-occlusive compositions.

Abstract: An adapter to couple a dissimilar, normally incompatible radiotherapeutic probe and radio frequency generator includes an adapter body having a proximal connector to be coupled to the generator, a distal connector to be coupled to the dissimilar, normally incompatible radiotherapeutic probe, and one or more electrical elements to emulate one or more operating parameters of a compatible, native radiotherapeutic probe to interface the generator with the dissimilar, normally incompatible radiotherapeutic probe.

Abstract: A catheter includes a first plurality of expandable leads and a second plurality of expandable leads separate and longitudinally spaced-apart from the first plurality to deliver energy to a hollow anatomical structure, such as vein, fallopian tube, hemorrhoid, esophageal varix, to effectively ligate that structure. Each of the leads includes an electrode located at the distal end of the respective electrode lead. Polarizations of the leads may be selected to achieve the power distribution desired. Each electrode lead includes an outward bend such that when a movable sheath is moved out of contact with the leads, they expand outwardly into apposition with an inner wall of the structure to be ligated. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure.

Abstract: Apparatus and method for retrieving a remotely located device equipped with a magnetic coupler is provided. The apparatus includes a magnetic coupling carried at an end of an elongate member for attracting the magnetic coupler of the remotely located device, and aligning the magnetic coupler with the magnetic coupling. A frictional engagement device, substantially housing the magnetic coupling therein, is adapted for trapping the magnetic coupler therein such that a retrieval force applied to the apparatus is transferred to the remotely located device via the frictional engagement device to thereby facilitate sure retrieval of the device as by magnetic mechanical entrapment.

Abstract: The method of the invention is to automatically activate an electromagnetic treating device as it is moved through a blood vessel so that an even amount of energy is dispensed per unit length of the blood vessel. Within reasonable limits, the EM device may be moved either slowly or quickly and still dispense the same amount of energy per unit length of blood vessel. An apparatus for performing the method includes an automatic switching apparatus for use with an EM device whereby activation of the EM device is automatically controlled as the EM device is moved through a blood vessel.

Abstract: A method of creating a tissue effect at a tissue site during a skin treatment is provided. An electromagnetic energy delivery device is coupled to an electromagnetic energy source. Different levels of cooling are applied to a skin surface during the skin treatment, wherein a reverse thermal gradient through the skin surface is created, at least during a portion of the skin treatment, where a temperature of the skin surface is lower than a temperature of the underlying tissue. Electromagnetic energy is applied through the skin surface to the underlying tissue, wherein the. A tissue effect is created on at least a portion of the tissue site.

Abstract: A self-limiting electrosurgical return electrode for use with electrosurgery. Through selection of impedance characteristics for the materials of the principal body of the electrode, and through tailoring of electrode geometries, the electrode is self-regulating and self-limiting as to current density and temperature rise to prevent patient trauma. The return electrode includes a sheet of material having an effective bulk impedance equal to or greater than about 4,000&OHgr;.cm and one or more connectors for making electrical connection to the sheet. The effective bulk impedance of the sheet may arise from resistive components, capacitive components, inductive components, or combinations thereof. Configuration of the return electrode allows the electrode to self-limit the electrode's current densities, thereby preventing burning of a patient during surgery. Through employment of washable surface areas, the electrode is made readily cleanable, disinfectable, sterilizable, and reusable.

Abstract: This is an implantable medical device assembly for use in surgical procedures. It is most preferably an implantable structure having stenting properties but only partially coated with or partially associated with a material causing a localized angiogenic response. One variation of is an artificial occlusion kit having the inventive implantable stenting structure situatable and vaso-occlusive devices. The implantable stenting structure is typically situated so to prevent migration of artificial occlusion devices or implants from an occlusion site, such as an aneurysm, and into an adjacent body space, such as a blood vessel.

Abstract: An excisional biopsy method is disclosed. The method can include rotating an arcuate shaped electrode around a tissue specimen, and drawing a sheath around the tissue specimen as the specimen is cut from a tissue mass. In one embodiment, the method includes tunneling to a tissue site with one electrode, and cutting with a second electrode to obtain the tissue specimen.

Abstract: Body lumens such as blood vessels are selectively occluded by applying radiofrequency voltage to a vaso-occlusive coil (100) at the target site (TS) and generating a thermal reaction to induce fibrogenic occlusion of the blood vessel (BV) around the vaso-occlusive coil. The radiofrequency current is usually sufficient to induce thermal damage to the luminal wall and to coagulate the surrounding blood, thereby initiating clotting and subsequent fibrosis to permanently occlude the lumen. The invention also includes a method for endoluminally deploying the vaso-occlusive coil and preventing migration of the coil from of the target site.

Abstract: The invention relates to a device for supplying electrical energy to an electro-pen with an electric drive unit for driving a tool. The device comprises a console with an energy supply unit having an accumulator for supplying the electrical drive unit with electrical energy. The console may be configure to be sterilized by steam having a housing and electrical components that are sealed liquid-tight. The accumulator may include a sterile covering for sterile introduction into the console. A coupling between the console and the electro-pen carries the supply of electrical energy from the console to the electro-pen. The coupling may be an electrical contact in the form of a sterilizable connector or an inductive coupling. The console may be configured to store energy and is thus mobile, or the console may include a connection for connecting to a mains or external power supply for charging the accumulator. The console may include a switch-mode power supply for charging the accumulator.

Abstract: A method of preparing and ablating heart tissue includes a pre-treatment step of delivering a jet of conductive fluid to a portion of heart tissue. The conductive fluid is delivered using an injection device such as a hand-held jet injector, probe, or catheter. After injecting the heart tissue with the conductive fluid, RF energy is delivered to the site of the injection to form a lesion. The method enables a physician to produce large and accurately placed lesions within the treated tissue.

Abstract: A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.

Abstract: An RF device includes a support structure coupled to an RF electrode that has conductive and dielectric portions. A cooling member is coupled to the support structure and is configured to cool a back surface of the RF electrode. The cooling member is distanced from the back surface of the RF electrode. A memory is coupled to the RF electrode. The memory is configured to store information to facilitate operation of at least one of the RF electrode, the cooling member and an RF energy source.

Abstract: Surgical methods and apparatus for positioning diagnostic an therapeutic elements on the epicardium or other organ surface.

Abstract: A system for treating a wide-neck aneurysm comprising a mesh-like sleeve fabricated from a class of polymer filaments that carry conductive particles therein to provide the filaments with a specified resistivity. The releasable mesh-like sleeve is introduced to the site of a targeted vascular malformation by the working end of a catheter that carries an electrode arrangement at its distal terminus. The system further provides an electrical source and controller (i) that modulates power delivery to the polymer matrix which can then fuse the sleeve to the wall of a blood vessel to span across the vascular malformation.

Abstract: A catheter having expandable electrodes for applying energy to a hollow anatomical structure such as a vein. When used on a vein, the catheter is useful for a minimally invasive treatment of venous insufficiency. The catheter includes conductive end rings to which the electrodes are attached, for mechanically connecting and electrically tying electrodes together to provide for a single wire electrical connection points, for transmitting energy while more evenly spacing the electrodes. Expandable arms are formed of electrically conductive material and insulated along their length except for an intermediate section that functions as the electrode. The arms are tapered to allow more room for wiring and to reduce the possibility of shorting between the ends of the arms. The catheter further includes thermocouples in the electrodes for measuring temperatures on the outer surface of the electrode. Slots are formed in the arms for mounting the thermocouples.

Abstract: An electrosurgical probe (10) comprises a shaft (13) having an electrode array (58) at-its distal end and a connector (19) at its proximal end for coupling the electrode array to a high frequency power supply (28). The shaft includes a return electrode (56) recessed from its distal end and enclosed within an insulating jacket (18). The return electrode defines an inner passage (83) electrically connected to both the return electrode and the electrode array for passage of an electrically conducting liquid (50). By applying high frequency voltage to the electrode array and the return electrode, the electrically conducting liquid generates a current flow path between the return electrode and the electrode array so that target tissue may be cut or ablated. The probe is particularly useful in dry environments, such as the mouth or abdominal cavity, because the electrically conducting liquid provides the necessary return current path between the active and return electrodes.

Abstract: Systems and methods are provided for removal (ablation) or modification of soft tissue with high frequency voltage through a capacitive charge process. Specifically, one of the conductors of a capacitor device maybe positioned adjacent to, or in the region of, a body structure. The other conductor is spaced, and electrically insulated from, the first conductor. A high frequency voltage is applied across the conductors to create a potential difference that results in a charge on the conductors and creates an electric field therebetween. High frequency alternating current flows between the conductors to a degree dependent on the capacitance and the current frequency. The charge on the first conductor is sufficient to modify the adjacent tissue. In some variations the charge is sufficient to heat the tissue for tissue coagulation or tissue shrinkage (i.e., collagen contraction). In other variations, the charge is sufficient to ablate or volumetrically remove the tissue.

Abstract: A method for making transmural lesions in one or more walls of the atria of the heart in open-heart surgery. The lesion blocks electrical impulses in a direction crosswise to the lesion. The method uses a probe having a handle (1), a closed electrode (2) at an end of the probe, a relatively rigid member (5) of physiologically acceptable plastic connecting the probe and the electrode, and means (6, 7) for coupling the probe to an RF power source.

Abstract: A method for producing preferential damage to hair exiting mammalian skin. A agent having an average diameter for enabling the agent to penetrate the hair duct is selected. The agent is designed to attach to, or become physically incorporated into, the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent has an electromagnetic radiation absorption characteristic which enables the agent to absorb a first wavelength of electromagnetic radiation from a skin-penetrating electromagnetic radiation source, such as a laser. The agent is applied to the skin so that the agent penetrates the skin and attaches to or becomes physically incorporated into the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent is exposed to the first wavelength of electromagnetic radiation and absorbs the first wavelength of electromagnetic radiation.

Abstract: The present invention relates to an apparatus for destroying a predetermined defined volume (10) in a tissue, such as generating controlled coagulation, so-called lesion, in the brain. More particularly, the apparatus comprises a main unit (1) for transmitting a tissue-destroying medium comprising a control unit (3) for controlling the medium transmission, and a transferring means (4), such as an electrode, which is connected to said main unit and adapted to be inserted into the predetermined volume for transferring the transmitted medium to the volume. The apparatus according to the invention is characterised in that it further comprises a measuring means (5-8) for measuring at least one optical characteristic of the predetermined volume, the optical characteristic varying with the size of the destroyed volume, the measuring means being connected to said control unit for controlling the supply of the tissue-destroying medium on the basis of the measured optical characteristic.

Abstract: An assembly for embolization is provided, which includes a simplified member and an embolic material inducing an improved thrombus in vascular malformations. The assembly comprises an implant to be inserted within the target site; and a guiding member with its distal end coupled with the implant, for guiding the implant to the target site, wherein the guiding member is made of an electrically conducting material and includes a multiplicity of tapered configurations.

Abstract: This is an implant for placement in the human body and a wire coupled to the implant for placing that implant. In the illustrated embodiment, it is an implant for use in the vasculature of the human body and is used to occlude a cavity in that vasculature as a portion of a treatment regimen. The implant itself is a component of a deployment device in which the implant is detached from the wire using electrolytic disintegration when a current is applied to the wire. The implant is electrically isolated from active participation in the electrolytic disintegration which occurs when a current is applied to the wire. Such isolation and minimization of the conductive pathway from the placement apparatus to the body's fluids appears to enhance the susceptibility of a selected portion of the wire to electrolysis to provide for quick erosion and detachment of the implant from the wire.

Abstract: The present invention provides systems and methods for selectively applying electrical energy to a target location within a patient's body, particularly including tissue in the spine. The present invention applies high frequency (RF) electrical energy to one or more electrode terminals in the presence of electrically conductive fluid to contract collagen fibers within the tissue structures. In one aspect of the invention, a system and method is provided for treating herniated or swollen discs within a patient's spine by applying sufficient electrical energy to the disc tissue to contract or shrink the collagen fibers within the nucleus pulposis. This causes the pulposis to shrink and withdraw from its impingement on the spinal nerve.

Abstract: An RF tonsillar probe comprises a generally elongated insulated structure having means for coupling to the bipolar outlet of electrosurgical apparatus, and two internal insulated wires leading to a distal end that is angled downwardly and that terminates in two laterally-spaced needle electrodes whose tips are exposed. The probe works best with relatively high-frequency RF electrosurgical currents in excess of 1.5 MHz. The combination of the bipolar mode with electrosurgical currents in the MHz range causes relatively low tissue temperatures avoiding the need for the addition of a complicated temperature-controller structure and suitable circuitry, and the bipolar action confines the RFTA effect to the tissue region between the two active needle electrodes.

Abstract: Systems, apparatus, and methods are provided for promoting blood flow to a target tissue. In one aspect, the invention involves canalizing or boring channels, divots, trenches or holes through an avascular connective tissue, or through a tissue having sparse vascularity, such as a tendon or a meniscus, in order to increase blood flow within the tissue. In one method, an active electrode is positioned in close proximity to a target site on a tendon, and a high frequency voltage difference is applied between the active electrode and a return electrode to selectively ablate tendon tissue at the target site, thereby forming a channel or void in the tendon. The active electrode(s) may be moved relative to the tendon during, or after, the application of electrical energy to damage or sculpt a void within the tendon, such as a hole, channel, crater, or the like.

Abstract: A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

Abstract: A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an efferent vagus nerve fiber, or the entire vagus nerve.

Abstract: Apparatus and methods for treating back pain of a patient by denervation of an intervertebral disc or a region of the posterior longitudinal ligament by the controlled application of heat to a target tissue. In one embodiment, the invention may include a procedure combining both decompression of a disc, and denervation of the annulus fibrosus. In one embodiment, a method of the invention includes positioning an active electrode of an electrosurgical instrument in at least close proximity to an intervertebral disc, and applying at least a first high frequency voltage between the active electrode and a return electrode, wherein nervous tissue within the annulus fibrosus is inactivated, and discogenic pain of the patient is alleviated.

Abstract: Apparatus and methods for treating an intervertebral disc by ablation of disc tissue. A method of the invention includes positioning at least one active electrode within the intervertebral disc, and applying at least a first high frequency voltage between the active electrode(s) and one or more return electrode(s), wherein the volume of the nucleus pulposus is decreased, pressure exerted by the nucleus pulposus on the annulus fibrosus is reduced, and discogenic pain of a patient is alleviated. In other embodiments, a curved or steerable probe is guided to a specific target site within a disc to be treated, and the disc tissue at the target site is ablated by application of at least a first high frequency voltage between the active electrode(s) and one or more return electrode(s). A method of making an electrosurgical probe is also disclosed.