Abstract: An electrosurgical forceps is provided with a shaft that extends from a housing of the electrosurgical forceps. An end effector assembly operably coupled to a distal end of the shaft includes a pair of first and second jaw members having proximal and distal ends. One or both of the first and second jaw members is movable from an open configuration for positioning tissue therebetween, to a clamping configuration for grasping tissue therebetween. A knife blade assembly includes a knife blade that is translatable within the first and second jaw members when the first and second jaw members are in the clamping configuration. The knife blade assembly includes a knife blade stop configured to contact at least a portion of the proximal end of the second jaw member when the first and second jaw members are in the open configuration to limit translation of the knife blade assembly.

Abstract: A self-limiting electrosurgical return electrode for use with electrosurgical procedures is disclosed. The return electrode includes a conductive element and pads disposed on opposing sides of the conductive element. The conductive element, optionally in combination with the pads, is configured to limit the density of electrical current that passes from a patient to the return electrode. The conductive element and the pads can cooperate to define two separate working surfaces on opposing sides of the return electrode. The return electrode can also be safely used with patients of substantially any size and without requiring adjustments to the power settings of an electrosurgical generator.

Abstract: A system for minimizing neuromuscular stimulation includes a converter, an inverter, and a controller. The converter is configured to output a dc waveform and includes at least one first switching element operated at a first duty cycle. The inverter is coupled to the converter and includes at least one second switching element operated at a second duty cycle. The inverter is configured to invert the DC waveform to generate an electrosurgical pulse waveform. The controller is coupled to the converter and the inverter, and is configured to control the first duty cycle to adjust a magnitude of the electrosurgical pulse waveform and the second duty cycle to adjust at least one property of the electrosurgical pulse waveform to minimize neuromuscular stimulation.

Abstract: Medical devices and methods for making and using the same are disclosed. An example medical device may include a medical device for renal nerve ablation. The medical device may include an elongate shaft having a distal region. An expandable member may be coupled to the distal region. A plurality of electrodes may be coupled to the expandable member and a single conductive member may be coupled to each electrode. Where one of the plurality of electrodes is active, the remaining electrodes may be inactive and act as ground or return electrodes. The electrode of the plurality of electrodes that is active may change over time.

Abstract: An energy delivery probe is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the energy can be applied with a vapor media. The energy delivery probe can include a vapor delivery member configured to extend into a transition zone prostate tissue. A condensable vapor media can be delivered from the vapor delivery member into the transition zone tissue, wherein the condensable vapor media can propagate interstitially in the transition zone tissue and be confined in the transition zone tissue by boundary tissue adjacent to the transition zone tissue Methods associated with use of the energy delivery probe are also covered.

Abstract: A method and system for increasing safety of cardiac ablation procedures comprises a computer based system that monitors the esophageal temperature, and a fluoroscopy (medical images) based cardiac mapping system for cryoballoon or radiofrequency (RF) ablations. The esophageal temperature is monitored utilizing an esophageal probe which may have any number of temperature sensing members. The esophageal probe may also have pre-formed shape. During atrial fibrillation ablations, based on a pre-determined increase in esophageal temperature (from any thermistor), the computer based system activates different levels of alarm(s), and/or initiates ablation energy interrupt based on pre-defined programmed values. The method and system is also used for guiding placement of cryoballoon and performing cryoablations. The placement of cryoballoon catheter or a circular catheter is based on superimposing a high resolution (dye injected) image and a live fluoroscopy image and adjusting transparency between the two images.

Abstract: A method of operating a surgical instrument is disclosed. The surgical instrument includes an electronic system comprising an electric motor coupled to the end effector; a motor controller coupled to the motor; a parameter threshold detection module configured to monitor multiple parameter thresholds; a sensing module configured to sense tissue compression; a processor coupled to the parameter threshold detection module and the motor controller; and a memory coupled to the processor. The memory stores executable instructions that when executed by the processor cause the processor to monitor multiple levels of action thresholds and monitor speed of the motor and increment a drive unit of the motor, sense tissue compression, and provide rate and control feedback to the user of the surgical instrument.

Abstract: A system for the manufacture of an end effector assembly which is configured for use with an electrosurgical instrument configured for performing an electrosurgical procedure is provided. The system includes a photolithography module that is configured to etch one or more pockets on a seal surface of the seal plate. A vacuum module is configured to raise, transfer and lower a spacer from a location remote from the pocket(s) on the seal plate to the pocket on the seal plate(s). An adhesive dispensing module is configured to dispense an adhesive into the pocket on the seal plate. An optical module is configured to monitor a volume of the adhesive dispensed within the pocket and monitor placement of the spacer within the pocket.

Abstract: This invention relates to high-frequency ablation of tissue in the body using a cooled high-frequency electrode connected to a high frequency generator including a computer graphic control system and an automatic controller for control the signal output from the generator, and adapted to display on a real time graphic display a measured parameter related to the ablation process and visually monitor the variation of the parameter of the signal output that is controlled by the controller during the ablation process. In one example, one or more measured parameters are displayed simultaneously to visually interpret the relation of their variation and values. In one example, the displayed one or more parameters can be taken from the list of measured voltage, current, power, impedance, electrode temperature, and tissue temperature related to the ablation process.

Abstract: A system for measuring real-time tissue reflection spectral characteristics during ablation includes a catheter for collecting light reflected from tissue undergoing ablation, a detection component for separating constituent wavelengths of the collected light, a quantification apparatus for generating measured light intensity data of the collected light, and a processor for analyzing the data in relation to time. A method for monitoring formation of steam pop during ablation includes delivering light to tissue, delivering ablative energy to the tissue, measuring the reflectance spectral intensity of the tissue, and observing whether the measured reflectance spectral instensity (MRSI) initially increases in a specified time period followed by a decrease at a specified rate. If the MRSI does not decrease, delivery of ablation energy continues.

Abstract: A loading data generator can be used with a scaffold for delivery within a patient. The loading data generator includes a driving circuit electrically coupled to drive an impedance of the scaffold. A detection circuit generates loading data based on the impedance of the scaffold, wherein the loading data indicates an amount of impregnation of the therapeutic material in the scaffold.

Abstract: System for electrically ablating tissue of a patient through a plurality of electrodes includes a memory, a processor and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region based on the number of electrical pulses to be applied.

Abstract: There are provided a system for ablation utilizing multiple electrodes and a method for controlling the system. The system includes: a main amplification unit providing main radio frequency (RF) power by amplifying received power; a sub-amplification unit providing sub-RF power by amplifying received power; a first switching unit transmitting the main RF power provided by the main amplification unit to one of first to third electrodes; a second switching unit transmitting the sub-RF power provided by the sub-amplification unit to one of the first to third electrodes; and a control unit controlling the first and second switching units to apply the main RF power and the sub-RF power to a pair of respective electrodes previously selected from the first to third electrodes.

Abstract: Methods and devices for improved precision in finding one or more nerves and then interrupting the transmission of neural signals through the target nerve. The treated nerve can be rendered incapable of transmitting neural signals for a select duration of time, where such a duration can be on a temporarily basis (e.g., hours, days or weeks) or a longer term/permanent basis (e.g., months or years). One embodiment of the apparatus includes a precise energy source system which features energy transfer elements that are capable of creating areas of nerve destruction, inhibition and ablation with precision.

Abstract: An ultrasonic medical treatment device has a probe, a transducer for mechanically vibrating the probe at an ultrasonic frequency, a voltage source for energizing the transducer, and another electrical voltage source for feeding to the probe a high-frequency alternating waveform of limited current and limited voltage to be conducted into a patient through the operative tip of the probe after placement of the operative tip into contact with the patient. The alternating waveform has a current and a voltage so limited as to prevent damage to organic tissues while stimulating nerves to reduce or suppress pain.

Abstract: A method and a device for generating a plasma in atmospheric-pressure, low-temperature conditions are described herein. The device described for the generation of the plasma comprises a first pair of electrodes, each of which separated by a dielectric layer and externally positioned with respect to a tubular duct where the gas flows, and a second pair of electrodes, also in this case each of which separated by a dielectric layer and externally positioned with respect to said tubular duct where the same gas flows downstream with respect to the first pair with respect to the direction of the flow. A high-frequency excitation is applied to the first pair of electrodes while a Radio-Frequency excitation is applied to the second pair of electrodes. The plasma generated in this manner emerges from the gas flow at the outlet of the transport duct.

Abstract: A forceps comprising: (a) a stylet comprising; (i) a hollow tube having a longitudinal axis; (ii) assemblies, that are extendable through the hollow tube, comprising; (1) support rods; (2) functional attachments at the end of the support rods; (b) a hand piece comprising; (i) housing structures defining a cavity that houses the stylet; (ii) actuating mechanisms, in communication with the stylet, comprising; (1) a bearing fitting located on the stylet; (2) a shuttle in communication with the bearing fitting, and constrained by a plurality of guide ridges so that the shuttle is movable along a longitudinal axis and restricted from rotational movement around the longitudinal axis; (3) a socket housed by the shuttle, the socket receiving the bearing fitting and being rotatable relative to the shuttle; and (4) levers in communication with the stylet that causes movement of the hollow tube and the assemblies are relative to each other.

Abstract: An apparatus for transcutaneously treating tissue beneath a skin surface using radiofrequency energy. The apparatus includes an electrode assembly supported by a handpiece. The electrode assembly includes an electrode configured to transfer the radiofrequency energy through the skin surface to the tissue. A force sensor, which is located in the handpiece, is configured to detect an amount of force applied by the electrode against the skin surface.

Abstract: The invention relates to an electro-optical distance-measuring device, more particularly a laser rangefinder, with a transmitting unit for transmitting intensity-modulated optical radiation, a receiving unit for receiving a portion of the optical radiation reflected back from a target in a photosensitive electrical component and converting it into an electrical received signal, an input filter for filtering the received signal, an analog-to-digital converter for digitizing the filtered received signal and an electronic analysis unit that calculates the distance from the rangefinder to the target object on the basis of a signal propagation time using the digitized received signal. The input filter is implemented as a time-discrete and continuous-value filter structure, more particularly a digital filter structure.

Abstract: Bipolar belt ablation systems and methods for treating patient tissue involve the use of an ablation an ablation apparatus with a plurality of ablation elements carried by a flexible tube structure, a radiofrequency generator capable of delivering a plurality of differing radiofrequency power signals to the ablation elements of the ablation device, wires transmitting the radiofrequency power signals from the radiofrequency generator to the ablation elements, and a control mechanism to enable temperature-based power control to each of the powered ablation elements.

Abstract: A circuit for discharging stored energy in an electrosurgical generator includes a pulse width modulator for controlling a high voltage power supply, an error signal generating circuit configured for delivering an error signal as a difference between an output signal voltage and a feedback voltage generated by the high voltage power supply. The circuit further includes a switching circuit configured to switch in a load in parallel with an output of the high voltage power supply when the error signal is less than a first predetermined threshold to discharge the output.

Abstract: Methods and apparatus are disclosed which reduce the stress concentration at the redistribution layers (RDLs) of a package device. A package device may comprise a seed layer above a passivation layer, covering an opening of the passivation layer, and covering and in contact with a contact pad. A RDL is formed above the passivation layer, above and in contact with the seed layer, covering the opening of the passivation layer, and electrically connected to the contact pad through the seed layer. The RDL has an end portion with a surface that is smooth without a right angle. The surface of the end portion of the RDL may have an obtuse angle, or a curved surface.

Abstract: Removal of damaged tissue itself can enable biosynthetic activity in vivo as an unburdened homeostatic or repair response. By removing a biologic and mechanical irritant, the lesion site can be altered to a more favorable perturbation-specific mechanotransductive environment supportive of differentiated gene expression. One aspect of one embodiment of the present invention provides an engineered irrigant that produces ion exchanges in tissues for example deliver of protons which interact with biology tissues.

Abstract: A system for measuring real-time tissue reflection spectral characteristics during ablation includes a catheter for collecting light reflected from tissue undergoing ablation, a detection component for separating constituent wavelengths of the collected light, a quantification apparatus for generating measured light intensity data of the collected light, and a processor for analyzing the data in relation to time. A method for monitoring formation of steam pop during ablation includes delivering light to tissue, delivering ablative energy to the tissue, measuring the reflectance spectral intensity of the tissue, and observing whether the measured reflectance spectral instensity (MRSI) initially increases in a specified time period followed by a decrease at a specified rate. If the MRSI does not decrease, delivery of ablation energy continues.

Abstract: Methods and systems facilitate catheterization of a living subject by passing a fluid through an irrigation conduit. Heat energy is delivered to the conduit to create a heated pod of irrigation fluid that propagates downstream from the heat source. A departure time of the pod from a first location in the conduit is recorded, and an arrival time of the pod is detected at a second location that is downstream from the first location. A transit time of the pod from the first location to the second location is determined, and the flow of the fluid is adjusted responsively to the transit time.

Abstract: An adherent device to monitor a tissue hydration of a patient comprises an adhesive patch to adhere to a skin of the patient. A plurality of electrodes are connected to the patch and capable of electrically coupling to the patient. Circuitry is coupled to the plurality of electrodes to measure a tissue resistance of the patient at a first frequency and to detect a low frequency droop in the measured tissue resistance. In response to detected low frequency droop, the circuitry is configured to measure a tissue resistance of the patient at a second frequency that is lower than the first frequency to verify the detection of low frequency droop, and to temporarily suspend data collection based on the detection and verification of low frequency droop.

Abstract: Described here are devices, systems, and methods for providing remote traction to tissue. Generally, the systems may include a grasper and a delivery device configured to releasably couple to the grasper. The grasper may have a first jaw and a second jaw and a main body having a barrel portion. The barrel portion may have a lumen extending therethrough, and a portion of the delivery device may be advanced through the lumen to rotate one or both of the jaws. The delivery devices may include a handle, a shaft, and a distal engagement portion. The delivery devices may further include an actuation rod which may be advanced through a barrel portion of a grasper to actuate the grasper. In some instances, the delivery device may further include a locking sheath, wherein the locking sheath is configured to temporarily couple to a grasper.

Abstract: A method for controlling an electrosurgical generator includes generating at least one electrosurgical waveform at a selected energy setting through an RF output stage comprising an RF inverter coupled to a power source. The at least one electrosurgical waveform has a duty cycle and a crest factor. The method also includes adjusting a repetition rate of the at least one electrosurgical waveform based on the selected energy setting to regulate the duty cycle of the at least one electrosurgical waveform. The method also includes applying the at least one electrosurgical waveform to tissue through at least one electrode and measuring an output voltage of the at least one electrosurgical waveform. The method also includes supplying a control signal to the RF inverter based on the repetition rate when the output voltage is increasing to regulate the crest factor of the at least one electrosurgical waveform.

Abstract: A method for implanting an electrical stimulation lead into a patient includes inserting an elongated sheath into a patient. The sheath includes a sheath body with a proximal end and a distal tip. The sheath defines a lumen extending from the proximal end of the sheath to the distal tip. The distal tip of the sheath is advanced to the patient's epidural space. The distal tip of the sheath is positioned at a target implantation location. A lead is advanced along the lumen of the sheath from the proximal end of the sheath body to the distal tip. The lead includes a lead body and a plurality of electrodes disposed along a distal end of the lead body. The sheath is removed from the patient while leaving the distal end of the lead at the target implantation location.

Abstract: A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.

Abstract: A system for the manufacture of an end effector assembly which is configured for use with an electrosurgical instrument configured for performing an electrosurgical procedure is provided. The system includes a photolithography module that is configured to etch one or more pockets on a seal surface of the seal plate. A vacuum module is configured to raise, transfer and lower a spacer from a location remote from the pocket(s) on the seal plate to the pocket on the seal plate(s). An adhesive dispensing module is configured to dispense an adhesive into the pocket on the seal plate. An optical module is configured to monitor a volume of the adhesive dispensed within the pocket and monitor placement of the spacer within the pocket.

Abstract: Devices and systems for ultrasonically imaging anatomical structures and performing ablation therapy within the body are disclosed. A combined ablation and ultrasound imaging probe includes a housing, an ablation electrode located on a distal tip section of the housing, and a number of ultrasonic imaging sensors configured for visualizing anatomical structures within the body. During an ablation procedure, the ultrasonic imaging sensors can be tasked to generate a number of ultrasonic images that can be displayed as a composite image on a display screen of a user interface.

Abstract: An electrosurgical generator is disclosed. The generator includes an RF output stage configured to supply electrosurgical energy to tissue via at least one active electrode configured to apply electrosurgical energy to tissue; sensing circuitry configured to measure impedance of tissue; and a controller. The controller is configured to determine occurrence of a tissue reaction as a function of a minimum impedance value and a predetermined rise in impedance, wherein tissue reaction corresponds to a boiling point of tissue fluid; generate a target impedance trajectory as a function of measured impedance and desired rate of change based on the tissue reaction determination, wherein the target impedance trajectory includes a plurality of target impedance values; and drive tissue impedance along the target impedance trajectory by adjusting the output of the electrosurgical generator to substantially match tissue impedance to a corresponding target impedance for at least a predetermined minimum time period.

Abstract: A renal denervation system includes a renal denervation catheter and a flow determining system. The renal denervation catheter includes a plurality of ablation members positioned at a distal end portion thereof. The renal denervation catheter is insertable into a renal artery. The flow determining system includes a processor and first and second flow determining members spaced apart on the renal denervation catheter. The processor is configured to determine a change in blood flow through the renal artery resulting from a renal denervation procedure using the renal denervation catheter in response to input from the first and second flow determining members.

Abstract: A cooling system for a surgical handpiece may provide fluid flow to the surgical tip and to the internal electronic components to prevent temperatures that may damage or make the patient or surgeon uncomfortable. Tip directed gas further controls the tip-tissue interface by displacing blood or serum from the incision point, increasing precision and diminishing coagulum build-up. In the alternative, cooling fluid may be used to quench tissue being treated.

Abstract: Systems and methods of use for guiding the flow of energy through a subject to stimulate tissue.

Abstract: Methods and devices for improved precision in finding one or more nerves and then interrupting the transmission of neural signals through the target nerve. The treated nerve can be rendered incapable of transmitting neural signals for a select duration of time, where such a duration can be on a temporary basis (e.g., hours, days or weeks) or a longer term/permanent basis (e.g., months or years). One embodiment of the apparatus includes a precise energy source system which features energy transfer elements that are capable of creating areas of nerve destruction, inhibition and ablation with precision.

Abstract: Methods and devices for improved precision in finding one or more nerves and then interrupting the transmission of neural signals through the target nerve. The treated nerve can be rendered incapable of transmitting neural signals for a select duration of time, where such a duration can be on a temporarily basis (e.g., hours, days or weeks) or a longer term/permanent basis (e.g., months or years). One embodiment of the apparatus includes a precise energy source system which features energy transfer elements that are capable of creating areas of nerve destruction, inhibition and ablation with precision.

Abstract: Systems, methods, and apparatus for providing power to an electrosurgical instrument. In particular, a power supply is disclosed in which non-sinusoidal (e.g., pulsed) constant frequency voltage having a variable amplitude is passed to an LC circuit to produce a quasi-sinusoidal current in the LC circuit. The constant driving frequency can be one half the resonant frequency of the LC circuit allowing the LC circuit to operate as an impedance, and thus limit current spikes and arcing. The frequency and phasing of the driving voltage also enables the LC circuit to discharge energy back into a power provider of the power supply so that energy does not build up in the LC circuit. These features result in less severe current spikes and arcing, as well as reduced cutoff times.

Abstract: A forceps includes an end effector assembly including first and second jaw members. One or both of the jaw members is movable relative to the other between a spaced-apart position and an approximated position for grasping tissue therebetween. One or both of the jaw members is configured to conduct energy between the jaw members and through tissue grasped therebetween to treat tissue. An insulative tubular member is movable relative to the end effector assembly between a retracted position, wherein the insulative tubular member is positioned proximally of the end effector assembly, and an extended position, wherein the insulative tubular member is disposed about the end effector assembly. A monopolar member is configured to apply energy to tissue to treat tissue when the insulative tubular member is disposed in the extended position.

Abstract: Medical devices and methods for making and using the same are disclosed. An example method may include a method for treating tissue near a body passageway using an apparatus including a catheter having a plurality of electrodes, a radio-frequency energy generator, and a controller coupling the energy generator to the plurality of electrodes and configured to selectively energize the electrodes. The method may include using the apparatus to subject the tissue near the body passageway to a plurality of energy treatment cycles. The treatment cycle may include determining desired voltages for at least a subset of the electrodes for maintaining a predetermined target temperature profile proximate the subset of electrodes, setting an output voltage of the energy generator to correspond to the desired voltage determined for one of the electrodes, and energizing at least some of the electrodes at the output voltage to deliver energy to the body passageway.

Abstract: A method and system for increasing safety of cardiac ablation procedures comprises a computer based system that monitors the esophageal temperature. During atrial fibrillation ablations, based on a pre-determined increase in esophageal temperature, the computer based system activates different levels of alarm(s), and/or initiates ablation energy interrupt based on pre-defined programmed values. In one embodiment, an esophageal cooling means is incorporated for cooling the esophagus during the procedure. If the temperature starts to increase a cooling means can be initiated and/or an ablation interrupt means is activated based on pre-determined events.

Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.

Abstract: The systems and methods of the present disclosure calibrate impedance loss model parameters associated with an electrosurgical system having no external cabling or having external cabling with a fixed or known reactance, and obtain accurate electrical measurements of a tissue site by compensating for impedance losses associated with the transmission line of an electrosurgical device using the calibrated impedance loss model parameters. A computer system stores voltage and current sensor data for a range of different test loads and calculates sensed impedance values for each test load. The computer system then predicts a phase value for each load using each respective load impedance value. The computer system back calculates impedance loss model parameters including a source impedance parameter and a leakage impedance parameter based upon the voltage and current sensor data, the predicted phase values, and the impedance values of the test loads.

Abstract: Medical devices and methods for making and using the same are disclosed. An example method may include renal-denervation treatment method. The method may include delivering an RF energy treatment to a tissue proximate a renal artery using a catheter assembly of a renal denervation catheter system. The denervation system may include an RF energy generator coupled with the catheter assembly by a controller. The method may also include applying neural activity stimulation to the tissue proximate the renal artery using the catheter assembly, assessing stimulated neural activity response of the tissue using the catheter assembly, and determining a parameter of the RF energy treatment based on the assessed neural activity.

Abstract: A fingertip-mountable electrosurgical instrument includes a monopolar electrode capable of directing energy into tissue, and a holder configured to be operably coupled to the monopolar electrode. The holder is also configured to be operably coupled to an energy source. The holder includes a housing body and one or more attachment members coupled to the housing body. The one or more attachment members are configured to be removeably attachable to a user's finger. The housing body includes a distal end and a proximal end. The monopolar electrode is mechanically coupled to the distal end of the housing body.

Abstract: An electrosurgical handpiece comprising a squeezable handle connected to extend and retract bipolar electrodes from a rigid tubular member. The bipolar electrodes comprise active separable distal ends and connecting links configured such that when the handle is unsqueezed, the active distal ends protrude from the distal end of the first tubular member and are adjacent one another, and when the handle is fully squeezed, the active distal ends are fully extended outwardly from the first tubular member and separate, and when the handle is relaxed but still partially squeezed, the active distal ends come together and touch first at their extreme ends and then touch over a broader area in a position to grasp tissue for receiving electrosurgical currents.

Abstract: A method and device for inducing anaesthesia in mammals by the application of RF energy to create hyperthermia derived neural anaesthesia. An RF generator drives a plurality of electrodes placed in tissue surrounding the target nerve fiber to desiccate the desired length of nerve fiber to be desiccated in a single deployment. The device allows high-speed selection/de-selection of bipolar electrode pairs or sets under continuous RF excitation. Activation of electrode pairs is adapted in response to sensed current density and temperature (by electrodes not in the current discharge activation phase) in order to create lesions of complex and well defined shape necessary for the production of hyperthermia derived neural anaesthesia.

Abstract: Provided herein are methods, systems, and devices for increasing IL-10 expression, inhibiting inflammation, and treating inflammatory conditions using thermal ablation.

Abstract: System and method for locating and identifying nerves innervating the wall of arteries such as the renal artery are disclosed. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether a dose of energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of the energy delivered to the nerve. The method includes at least the steps to evaluate a change in physiological parameters after a dose of energy is delivered to an arterial wall; and to determine the type of nerve that the energy was directed to (none, sympathetic or parasympathetic) based on the results of the evaluation. The system includes at least a device for delivering a dose of energy to the wall of an artery; sensors for detecting physiological signals from a subject; and indicators to display the results obtained using the said method.