Abstract: A device for fixating a suture anchor beyond a hard tissue opening with the aid of a material having thermoplastic properties and energy transmitted to the suture anchor for in situ liquefaction of at least part of the material having thermoplastic properties. The device includes a tool and a suture anchor. The tool has a proximal end suitable for being coupled to an energy source and a distal end suitable for arrangement of the suture anchor including the suture. The distal end includes a distal tool face and an axial channel with a distal mouth located in the distal tool face. The suture anchor has an anchor foot and a thermoplastic sleeve including the material having thermoplastic properties. The anchor foot holds a loop of a suture such that end sections of the suture reach through the thermoplastic sleeve and a portion of the distal tool face.

Abstract: Disclosed herein is a method of using a biomaterial for treating a condition. The biomaterial can comprise a plurality of geometric elements. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

Abstract: A method for treating a spine comprising the steps of: connecting at least one first fastener that defines an implant cavity with at least one vertebral level of a first portion of vertebrae; connecting at least one second fastener with at least one vertebral level of a second portion of the vertebrae; manipulating the vertebrae; manipulating a spinal rod to a selected configuration; connecting the spinal rod with the at least one first fastener such that the spinal rod is disposed at a selected position with the implant cavity; connecting a tether to a second fastener and the spinal rod; and reducing the spinal rod to a selected position relative to the second fastener with the tether. Systems, spinal constructs and surgical instruments are disclosed.

Abstract: A dental implant for insertion into bone within a patient's mouth comprises a body and a scannable code. The body includes a bone-engaging exterior surface, an anti-rotational feature for non-rotationally mating with an abutment, and an upper region. The upper region includes an upper surface for engaging the abutment. The scannable code on the upper surface provides information concerning the dental implant. The information includes at least two features of the dental implant.

Abstract: The present invention provides an orthopedic implant comprising a continuous reinforced composite filament in a freely predetermined fiber orientation in multiple continuous successive layers, wherein the continuous reinforced composite filament comprises a bioabsorbable polymer matrix and a continuous bioabsorbable reinforcing fiber or fiber bundle, and whereby the continuous bioabsorbable reinforcing fiber or fiber bundle of consecutive layers at least partly intermingles and/or intertwines forming a three dimensionally interlocked continuous fiber structure.

Abstract: A bi-directional fixating transvertebral (BDFT) screw/cage apparatus is provided. The BDFT apparatus includes an intervertebral cage including a plurality of internal angled screw guides, a plurality of screw members, and a cage indentation adjacent to the screw guides that independently or supplemented by other screw locking mechanisms prevents the screw members from pulling out of the internal angled screw guides. The internal angled screw guides orient a first screw member superiorly and a second screw member inferiorly. The intervertebral cage is adapted for posterior lumbar intervertebral placement, anterior lumbar intervertebral placement, anterio-lateral thoracic intervertebral placement, or anterior cervical intervertebral placement.

Abstract: An interbody implant can comprise a cage and a porous structure. The cage can comprise an anterior segment, a medial segment, a posterior segment and a lateral segment contiguously connected to each other to define an interior space. The porous structure can be located in the interior space and can be bounded by the cage. The porous structure can comprise opposed superior and inferior surfaces exposed through the cage, an internal cavity located in an interior of the porous structure, and a plurality of ports connecting the internal cavity to the superior and inferior surfaces. A superior-inferior stiffness of the interbody implant can be defined by the porous structure. The porous structure can be compressed within a patient by movement of the spine to biologically stimulate bone growth in vertebrae adjacent the interbody implant. The implant can be configured for lateral, anterior and posterior insertion at different spine levels.

Abstract: An orthopaedic fixation assembly for prosthetic biologic attachment. The orthopaedic fixation assembly may include a main body with a longitudinally-extending stem having a proximal end, a distal end, and a cavity body. An anchor plug may be configured to be received within the stem cavity, and securable thereto via complementary mating surfaces. A spindle structure may be fixedly attached to the proximal end of the longitudinally-extending stem and protrude outwardly therefrom such that a portion of the structure extends externally beyond the resected cavity of the bone that may prevent rotational motion of the spindle. The spindle structure may have at least one compliant biasing member configured to apply a compressive force to the surrounding bone. A porous coating may be at the juncture between stem and spindle structure, on the spindle, and the splines and anti-rotation chocks, improving the initial stability of the implant and facilitating long-term bone ingrowth.

Abstract: A method of producing a product inorganic compound including: immersing a raw material inorganic compound having a volume of 10?13 m3 or more in an electrolyte aqueous solution or an electrolyte suspension; exchanging anions in the raw material inorganic compound with anions in the electrolyte aqueous solution or the electrolyte suspension; cations in the raw material inorganic compound are exchanged with cations in the electrolyte aqueous solution or the electrolyte suspension; or including a component (that excludes water, hydrogen, and oxygen) in the electrolyte aqueous solution or the electrolyte suspension not included in the raw material inorganic compound in the raw material inorganic compound; and obtaining a product inorganic compound having a volume of 10?13 m3 or more from the raw material inorganic compound.

Abstract: A bone fastener includes a screw shaft having a proximal portion and a distal portion. The proximal portion is formed by a first manufacturing method and defines a distal face. The distal portion is formed onto the distal face by a second manufacturing method. In some embodiments, systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A method for making a ceramic body comprised of a ceramic material having an inhibitory effect on bacterial growth is provided. A dental prosthesis may be made of a ceramic material that comprises a molybdenum-containing component on a portion of the prosthesis that contacts the gingival surface of a patient. In one method, a porous zirconia ceramic structure is shaped in the form of a dental prosthesis, and then infiltrated with a molybdenum-containing composition, before sintering to densify the ceramic structure.

Abstract: Intersomatic cage for vertebral stabilization, including a generally prismatic body having an outer rigid framework in the form of a truss within which at least one insert incorporating slow prolonged release substances selected from the classes of anti-inflammatory, anti-infection and bone regrowth promoter drugs is housed.

Abstract: A surgical kit includes a shield for covering a portion of the spine of a subject. The shield can include an attachment portion adapted to engage a bone fixation assembly which is adapted to be fixed on multiple vertebra bones of the subject. The bone fixation assembly can include a vertebra joining member secured between two bone anchors. Each bone anchor can include a fastener portion adapted to be implanted into a vertebra bone and a head coupling portion adapted to secure the vertebra joining member. The shield can be coupled to the bone fixation assembly via separate coupling elements, such as a clip or an adjustable link secured between two vertebra joining members of the bone fixation assembly. Alternatively, the shield can include an integral attachment portion configured to engage the bone fixation assembly directly.

Abstract: Osteotomy systems, devices, and methods for using the osteotomy systems are disclosed. The osteotomy system including an alignment device, at least one k-wire for insertion into the alignment device, and a cut guide with at least one hole for receiving at least one k-wire and a slot for receiving a saw blade. An osteotomy kit including an alignment device, cut guide, and position rotation device. The alignment device, cut guide, position rotation device, and bone plate are also disclosed. Finally, a method for fusing bones using the osteotomy system is also disclosed.

Abstract: Medical devices, such as orthopedic medical implants, and corresponding methods of applying a porous coating to the medical device are disclosed. In some embodiments, a medical device may include a plurality of texture features extending from a base surface, and a porous coating applied into and atop of the plurality of texture features and the base surface. The porous coating may include a plurality of coating structures, wherein a first coating structure group of the plurality of coating structures has a first size, wherein a second coating structure group of the plurality of coating structures has a second size, and wherein the first size is different than the second size.

Abstract: Briefly, the invention relates to a surgical tool and method for forming a pilot bore by inserting a guide wire into bone. The surgical tool is constructed and arranged for use in conjunction with X-ray or ultrasound machines. More particularly, the device includes a cannulated hand grip and driving tool used for the rotation of a bone or pedicle screw into bone. The rear portion of the hand grip includes a slide assembly that is suited to grip a guide wire. The slide assembly includes a user adjustable stop to control the sliding movement of the guide wire. The rear surface of the slide is constructed to be impacted with a hammer or similar device, whereby the stop prevents the guide wire from penetrating the bone further than desired. Should it be desired that the wire be retracted, a jack member is included to allow the wire to be precisely retracted.

Abstract: A void occlusion device that includes a scaffold defining a plurality of voids and a reinforcement member is described. The scaffold is configured to permit the infiltration of human tissue into the plurality of voids. The reinforcement member extends through at least a portion of the scaffold and is configured to resist compressive forces exerted on the scaffold. Also described are embodiments where the void occlusion device is biocompatible, bioresorbable, elastic, and suitable for radio imaging.

Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.

Abstract: A method for treating joint pain in a subject is disclosed. The method can include inserting a bone dowel and a first portion of a bone marrow aspirate into a subchondral region of a bone that is part of a joint being treated and introducing a second portion of the bone marrow aspirate into the intraarticular space of the joint being treated.

Abstract: An anterior cervical plate system with integrated locks which is additively manufactured as one component is disclosed. The anterior cervical plate system comprises a plate having at least one through hole configured to receive a bone screw for attaching the plate to a patient's bone. The plate includes a lock component adjacent to the at least one through hole. The lock component is connected to the plate such that the lock component is permitted to rotate with respect to the plate. The lock component has an unlocked position in which the locking ends of the lock component do not cover the head of the bone screw inside the through hole, and a locked position in which at least part of the locking ends engage the head portion of the bone screw to prevent the bone screw from backing out of the through hole.

Abstract: A medical polymer material in which a phosphate group having a C—O—P chemical bond including elemental C in a main chain of a structural formula is present on a surface of a polymer material substantially free of phosphate and hydroxy groups except for ends in the structural formula.

Abstract: The invention provides a nonmetal implant screw locking structure, which has the advantages of simple structure, novel design, simple production and processing, and convenient clinical operation. In addition, the structure of the invention can be used for orthopedic nonmetal implants such as the bone injury repair plate, spinal fusion cage, spinal fixation plate, posterior cervical single trapdoor plate, posterior cervical plate, lumbar anterior plate and lumbosacral plate, bringing good economic and social benefits gradually.

Abstract: A process for producing a calcium phosphate reactant, according to which: in a first step, use is made of a source of calcium and a source of phosphate ions in water, in a molar ratio that is adjusted so as to obtain a Ca/P molar ratio of between 0.5 and 1.6, and the source of calcium is reacted with the phosphate ions at a pH of between 2 and 8, in order to obtain a suspension (A) of calcium phosphate, and in a second step, added to the suspension (A) are an alkaline compound comprising hydroxide ions in order to set a pH of more than 8 and an additional source of calcium in order to obtain a suspension (B) of calcium phosphate reactant having a Ca/P molar ratio of more than 1.6. A calcium phosphate reactant obtainable by such a process.

Abstract: Surgical plating systems, devices, and related methods for stabilizing and immobilizing portions of a body for surgical procedures, e.g., spinal surgery, are disclosed herein. The plating systems can have narrow profiles that minimize trauma to the patient. An exemplary bone plating system can include a bone plate having one or more holes for receiving attachment members to couple the bone plate to a bony structure. The plating system can provide multipoint fixation to anatomical structures of the patient to prevent unwanted migration of the bone plate and/or unintentional back-out of the attachment members. In some embodiments, the attachment members can be disposed at various trajectories and angles relative to plating structures and can include a mesh construct and/or additional locking features. In some embodiments, the plating system can be introduced into the patient via an access tube to further limit the invasiveness of the procedure.

Abstract: A woven retention device for interfacing with a bone surface is provided that includes a sleeve body that can surround a fastener, a proximal end for receiving the fastener, and a distal end. The sleeve body includes interwoven monofilaments of different diameters forming a substantially tubular lattice with protuberances distributed on interior and exterior surfaces of the lattice at a predetermined spatial relationship. In a first state, the sleeve body has a plurality of combinations of filament cross-section geometries at the intersection points, forming a plurality of protuberance thicknesses as measured in a radial direction of the sleeve body. In a second state when a fastener is inserted into the tubular lattice, pressure from the fastener is transmitted to the tubular lattice such that the spatial relationship of the protuberances changes according to a function of bone density and an interfacing surface shape of the fastener.

Abstract: Orthopedic implants produced by additive manufacture, followed by refinement of exterior and interior surfaces trough mechanical erosion, chemical erosion, or a combination of mechanical and chemical erosion. Surface refinement removes debris, and also produces bone-growth enhancing micro-scale and nano-scale structures.

Abstract: Orthopedic implants produced by additive manufacture, followed by refinement of exterior and interior surfaces trough mechanical erosion, chemical erosion, or a combination of mechanical and chemical erosion. Surface refinement removes debris, and also produces bone-growth enhancing micro-scale and nano-scale structures.

Abstract: A method for making a ceramic body comprised of a ceramic material having an inhibitory effect on bacterial growth is provided. A dental prosthesis may be made of a ceramic material that comprises a molybdenum-containing component on a portion of the prosthesis that contacts the gingival surface of a patient. In one method, a porous zirconia ceramic structure is shaped in the form of a dental prosthesis, and then infiltrated with a molybdenum-containing composition, before sintering to densify the ceramic structure.

Abstract: The present invention is directed to a method of reducing the risk of infection following surgery utilizing the drug eluting surgical screw disclosed herein to secure an implant in an animal following surgery. The drug eluting screw includes a drug eluting component that can elute a therapeutic agent locally at the surface of the implant reducing the risk of infection.

Abstract: A bone fastener includes a screw shaft having a proximal portion and a distal portion. The proximal portion is formed by a first manufacturing method and defines a distal face. The distal portion is formed onto the distal face by a second manufacturing method. In some embodiments, systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: Embodiments of this application relate to the use of porous coating implants to repair soft tissue injuries. Implant frames are coated with a porous coating, such as a titanium porous coating, for example, on both the bone-facing and the soft tissue-facing sides of the implant. The implant may then be sandwiched between the bone and soft tissue so that the bone grows into one side, and the soft tissue grows into the other side.

Abstract: The present invention relates to a percutaneous implant abutment for bone anchored implant devices adapted to be anchored in the craniofacial region of a person, such as bone anchored hearing aids. The abutment comprises a skin penetration body having a skin contacting surface. The skin contacting surface has been modified.

Abstract: An anchoring system is a combination of a nanofiber scaffold material and an arthroscopically deployable suture anchor. The anchor is deployed into a bone tunnel using common techniques. The nanofiber material extends out of the proximal end of the implant, once deployed. The implant also includes pre-loaded sutures or has the ability to accept and lock sutures to the implant. For an implant pre-loaded with suture, the implant is placed into the bone, the material is deployed above the anchor onto the surface of the bone, suture is passed through the soft tissue, and knots are tied to secure the tissue against the bone, sandwiching the material between the bone and tissue, to provide a pathway for cells from the bone marrow to the soft tissue-bone interface, promote the healing response, provide a biomimetic structure that cells readily adhere to, and create a larger healing footprint.

Abstract: Disposable temporary spacer device for an articulation of the human body or for a bone cavity, wherein the spacer device includes at least one first component adapted to be constrained to a bone portion or end, wherein the spacer device is made from a biologically compatible material and comprises interconnected pores distributed in the entire volume occupied by the spacer device, in which the interconnected pores have a size and occupy a percentage of the volume of the spacer device such that it is able to absorb and consequently elute one or more pharmaceutical or medical substances in liquid or fluid form or in paste, cream, gel, wax, or viscous form.

Abstract: A joint prosthesis system is suitable for cementless fixation. The system has two metal implant components and a bearing. One of the metal implant components has an articulation surface for articulation with the bearing. The other metal implant component has a mounting surface for supporting the bearing. One of the metal implant components includes a solid metal portion and a porous metal portion. The porous metal portion has surfaces with different characteristics, such as roughness, to improve bone fixation, ease removal of the implant component in a revision surgery, reduce soft tissue irritation, improve the strength of a sintered bond between the solid and porous metal portions, or reduce or eliminate the possibility of blood traveling through the porous metal portion into the joint space. A method of making the joint prosthesis is also disclosed. The invention may also be applied to discrete porous metal implant components, such as augment.

Abstract: A bone fastener includes a screw shaft having a proximal portion and a distal portion. The proximal portion is formed by a first manufacturing method and defines a distal face. The distal portion is formed onto the distal face by a second manufacturing method. In some embodiments, systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: A bone clamp having a first jaw, an opposed second jaw and a drill guide, the drill guide being attached to the first jaw so that bone held between the first jaw and the second jaw can be drilled by a drill inserted through the drill guide, the first jaw having a longitudinal axis. The drill guide can be ball shaped at one distal end thereof that is positioned sufficiently within and retained within a corresponding cavity of the first jaw so that the angle of the drill guide can be adjusted to compound angles in the longitudinal and transverse directions in relation to the longitudinal axis of the first jaw. The bone clamp preferably comprises an organic polymer that is relatively transparent to X-rays.

Abstract: A method comprising molding a first component from a first feedstock comprising a first material powder and a first binder, molding a second component from a second feedstock comprising a second material powder and a second binder, placing the first component and the second component in physical communication with each other in order to form an assembled component, removing the first binder and the second binder from the assembled component and performing a sintering operation on the assembled component so as to bond the first component and the second component together.

Abstract: A hardenable multi-part acrylic composition comprises a solid first part and a storage stable liquid second part and optionally, further solid and/or liquid parts, the parts being operable to form a cement which hardens to a solid mass upon mixing. The composition further comprises an acrylic monomer component in the second part, an initiator component, a first sub-population of acrylic polymer particles in the first and/or further parts, a second sub-population of acrylic polymer particles in the first and/or further parts and optionally, one or more further sub-population(s) of acrylic polymer particles, and a radiopacifying filler. The initiator component amount is effective to polymerize the acrylic monomer component upon mixing. At least some of the radiopacifying filler is encapsulated within and/or adsorbed on the first sub-population of acrylic polymer particles and the second sub-population of acrylic polymer particles has a lower average particle size than the first.

Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of a cavity of a bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the support structure by an adhesive. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining the channel between the pair of components.

Abstract: A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of a cavity of a bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the support structure by an adhesive. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining the channel between the pair of components.

Abstract: A method for augmenting a tissue including introducing into the tissue a first thermoplastic material at a first condition; treating the first thermoplastic material to achieve a second condition that includes an at least partially crystalline skin; and introducing a second material into the tissue whereby the first thermoplastic material and the second material are contained by the at least partially crystalline skin. Also a method of fracture reduction in a tissue including exposing to gamma radiation a mass of polycaprolactone characterized by a first shape; heating the mass of irradiated polycaprolactone above its melting temperature; introducing the heated mass of polycaprolactone into the tissue annulus to deform it from the first shape; allowing the material to return to the first shape.

Abstract: A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer may be grown from the metal substrate, by anodising, and the biocidal material incorporated in it by ion exchange. Alternatively the layer may be deposited by electroplating, followed by diffusion bonding so as to become integral with the metal substrate. In either case, silver is a suitable biocidal material; and both the release rate and the quantity of biocidal material should be low to avoid toxic effects on body cells. Electropolishing the surface before formation of the surface layer is also beneficial, and this may be achieved by electropolishing.

Abstract: An implant is provided with a main body (1) and with a double coating applied to at least one surface section of the main body (1), wherein the double coating comprises an adhesion promoter layer (2), applied directly to the at least one surface section of the main body, and of an osteointegrative layer (3) covering the adhesion promoter layer (2). The layers (2;3) consist of pure titanium, wherein the adhesion promoter layer (2) has a thickness of 2-6 ?m, in particular a thickness of 3-5 ?m, and the osteointegrative layer (3) has a thickness of 50-70 ?m, in particular of 55-65 ?m. Moreover, the osteointegrative layer (3) has a porosity of 70-90% and a roughness Rz of at least 45 ?m. A related method is also provided for producing such an implant.

Abstract: A composite fixation device is described herein which includes a first and second biodegradable material. The first and second biodegradable materials degrade at different rates thereby permitting tissue ingrowth into the device prior to degradation of the entire device.

Abstract: An implant designed e.g. as a replacement for an articulating surface of a human or animal joint is secured to the bone tissue with the aid of a plurality of fasteners (3). The implant (2) comprises a bone side to be brought into contact with the bone tissue, which bone side is equipped with a plurality of fastening structures restricted to this bone side. The fasteners (3) comprise a distal and a proximal side, wherein the distal side is equipped for being anchored in bone tissue and the proximal side is equipped for being connected with one of the fastening structures of the implant (2). The distal sides of the fasteners (3) are anchored in the bone tissue of the appropriately prepared bone and the implant (2) is then attached to the anchored fasteners (3) by connecting the fastening structures with the proximal sides of the fasteners (3), wherein the implant (2) is pressed against the proximal sides of the anchored fasteners (3).

Abstract: An articulable elbow spacer includes a humeral component, an ulnar component, and a tie. The humeral component includes a proximal end having a rod for insertion into a humeral canal and a distal end including a first joint member, the first joint member including antibiotic cement and one or more tunnels. The ulnar component includes a proximal end including a second joint member, the second joint member including antibiotic cement and including one or more tunnels, and configured to receive the first joint member and a distal end having a rod for insertion into an ulnar canal. The tie is configured to link the humeral component to the ulnar component and is configured for insertion into the one or more tunnels of the first joint member and the one or more tunnels of the second joint member.

Abstract: A bone screw and method of producing the same is described. The method of producing a bone screw includes forming a one-piece headless screw body out of a rigid metallic foam that is entirely porous throughout and defines a plurality of inter-connected pores having a size of about 30 to about 500 microns in diameter. The method includes providing at least one thread on an external surface of the screw body, and forming a bore extending through an entire axial length of the screw body, the bore forming a cannula that defines an annular radial wall thickness of the screw body. The method further includes disposing the inter-connected pores throughout the radial wall thickness of the screw body such as to allow for bone in-growth through the full radial wall thickness and into the cannula.

Abstract: A magnesium-based medical device which can adjust a degree of corrosion within a wide range of period such that the device can maintain a sufficient strength only during a desired period and disappears within a desired period thereafter and a manufacturing method thereof are provided. A magnesium-based medical device of the present invention is a magnesium-based medical device in which a base material is made of magnesium or a magnesium alloy, wherein a corrosion-resistant film is formed on a surface of the base material, and variation in surface hardness of the formed corrosion-resistant film in the in-plane direction is less than 21 in terms of a dispersion value of Vickers hardness.

Abstract: A flexible, bendable organic decalcified or partially decalcified bone, cortical or cancellous, adapted for use in augmentation or repair of animal skeletal structures comprising a continuous plate or sheet of natural bone, as well as dermis is described. The thickness, flexibility and tensile strength of the construct is such as to allow it to be shaped and contoured without damage to it. The composition is ultimately remodeled by the body, thus obviating the need for additional surgical intervention. The clinical indications for the use of the invented construct are many, but are particularly prominent in dentistry, oral and maxillofacial surgery and implantology. It is particularly useful in the maxillary sinus augmentation. A unique new method, different from previously described methods for the preparation of the disclosed constructs, is described.