Anastomosis Patents (Class 606/8)
  • Patent number: 10172973
    Abstract: Surgical adjuncts and medicants for promoting lung function are provided. In general, an implantable adjunct can have one or more medicants releasably retained therein that are configured to promote lung function. The adjunct can be configured to be applied to lung tissue in conjunction with surgical staples using a surgical stapler. The one or more medicants can be configured to promote lung function in a variety of ways. For example, the one or more medicants can be effective to increase oxygen concentration. For another example of the one or more medicants being configured to promote lung function, the at least one medicant can be configured to treat contaminants in lung tissue.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: January 8, 2019
    Assignee: Ethicon LLC
    Inventors: Michael J. Vendely, Frederick E. Shelton, IV, Jason L. Harris
  • Patent number: 10085802
    Abstract: An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Additional embodiments include spacing/centering mechanisms to keep emitting end radially equidistant from vein walls. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: October 2, 2018
    Assignee: Biolitec Unternehmensbeteiligungs II AG
    Inventor: Wolfgang Neuberger
  • Patent number: 8961502
    Abstract: The invention provides a device and method for illuminating a body surface. A light source is optically coupled to the proximal end of a light guide and a light scatterer is optically coupled to the distal end of the light guide. The device includes a deployment mechanism that is configured to bring the light scatterer from a small caliber configuration in which the light scatterer is delivered to the body surface to a large caliber configuration in which the light scatterer irradiates the body surface. The invention may be used, for example, irradiate the periadventitial surface of an aneurysmal blood vessel.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: February 24, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: David Gertz, Lilach Gavish, Petachia Reissman
  • Patent number: 8790288
    Abstract: An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is well suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, for instance, the arteriovenous graft system includes a first valve device positioned at the arterial end and a second valve device positioned at the venous end. In one embodiment, the valve devices may include an inflatable balloon that, when inflated, constricts and closes off the arteriovenous graft. If desired, a single actuator can be used to open and close both valve devices.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: July 29, 2014
    Inventor: David L. Cull
  • Patent number: 8790358
    Abstract: Methods and apparatus for making an anastomotic connection between an opening at an end of a graft conduit and an aperture in a side wall of a body tissue conduit using a hollow connector assembly are provided, wherein the cross-sectional area of the anastomotic connection is larger than that of the graft conduit. The tissue about the opening is introduced about and retained by first members of a distal portion of the connector assembly held by a loading tool. A delivery tool then collapses a proximal portion defined by second members of the connector assembly and delivers the second members into the lumen of the body tissue conduit via the aperture. Upon inserting the second members into the body tissue conduit, the delivery tool is disemployed and the second members expand such that they press against the interior wall of the body tissue conduit and such that the first members are held within the aperture against a medial wall of the body tissue conduit.
    Type: Grant
    Filed: March 29, 2004
    Date of Patent: July 29, 2014
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Matthew Baker, Michael P. Brenzel, David Costello, Todd A. Krinke, John Logan, Alex A. Peterson
  • Patent number: 8728105
    Abstract: A magnetic anastomosis device is provided for forming an anastomosis between two bodily walls. The device includes a first magnet assembly and a second magnet assembly configured to be magnetically coupled to compress the two bodily walls therebetween to form the anastomosis. The first magnet assembly includes a first magnet and a second magnet disposed within a first jacket and the second magnet assembly includes a third magnet and a fourth magnet disposed within a second jacket.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: May 20, 2014
    Assignee: Cook Medical Technologies LLC
    Inventor: Andres F. Aguirre
  • Patent number: 8702769
    Abstract: A technique for detecting and providing alerts or indications that can be used for controlling or altering the displacement speed of an applicator coupling skin heating energy across a treated skin. A temperature sensor monitors the rate of skin temperature change and provides feedback related to altering the applicator displacement speed according to the rate of skin temperature change. Disclosed is also an applicator for implementing this method.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: April 22, 2014
    Assignee: Syneron Medical Ltd
    Inventors: Shimon Eckhouse, Lion Flyash, Boris Vaynberg
  • Publication number: 20140066910
    Abstract: A medical instrument includes two jaw members, at least one of which creates conditions of frustrated total internal reflection at a tissue-contacting surface when tissue is grasped between the two jaw members. The first jaw member may include an optical element having a tissue-contacting surface. The medical instrument also includes a light source that provides a light beam for sealing tissue. The light source is positioned so that the light beam is totally internally reflected from an interface between the tissue-contacting surface and air when tissue is not grasped by the jaw members. When tissue is grasped by the jaw members, at least a portion of the light beam is transmitted through that portion of the tissue-contacting surface that is in contact with the tissue. The light source may be movably coupled to a jaw member to scan the light beam and/or to change the incident angle based on optical properties of the tissue.
    Type: Application
    Filed: May 28, 2013
    Publication date: March 6, 2014
    Applicant: COVIDIEN LP
    Inventor: William H. NAU, JR.
  • Publication number: 20140066911
    Abstract: A medical instrument includes two jaw members, at least one of which creates conditions of frustrated total internal reflection at a tissue-contacting surface when tissue is grasped between the two jaw members. The first jaw member may include an optical element having a tissue-contacting surface. The medical instrument also includes a light source that provides a light beam for sealing tissue. The light source is positioned so that the light beam is totally internally reflected from an interface between the tissue-contacting surface and air when tissue is not grasped by the jaw members. When tissue is grasped by the jaw members, at least a portion of the light beam is transmitted through that portion of the tissue-contacting surface that is in contact with the tissue. The light source may be movably coupled to a jaw member to scan the light beam and/or to change the incident angle based on optical properties of the tissue.
    Type: Application
    Filed: May 28, 2013
    Publication date: March 6, 2014
    Applicant: COVIDIEN LP
    Inventor: WILLIAM H. NAU, JR.
  • Patent number: 8518027
    Abstract: A phototherapy device includes a light source; a light emanation block; and a heat exchanger for the dissipation of heat from one or more heat loads associated with the device. Heat may be transferred via the heat exchanger from the light source independently of the dissipation of heat from one or more of the other device heat loads. Substantially thermally isolated heat transfer regions may be provided, and such regions may be maintained at different operating temperatures, to control the transfer of heat in conjunction with a phototherapy method and to promote efficient and enhanced device operation and performance.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: August 27, 2013
    Assignee: Tria Beauty, Inc.
    Inventors: Mark V. Weckwerth, Charles A. Schuetz, Harvey I. Liu, Patrick Reichert, Tobin C. Island, Robert E. Grove
  • Publication number: 20130131655
    Abstract: A tissue transfer method for reconstruction and augmentation of soft tissue. The method includes harvesting adipose tissue from a patient. The harvested tissue is processed via centrifugation to isolate a purified subset of the adipose tissue including separating and removing a substantial amount of triglycerides from the harvested adipose tissue. The centrifugation may be performed to cause separation of water from the purified adipose tissue and to cause separation of oil from mature adipocytes. Specifically, the spin rates may be selected to be high enough to cause lesions in the mature adipocytes that results in the release of the oil. The method continues with implanting the purified adipose tissue into the patient at a breast or other area identified for reconstruction or augmentation. The implanting is performed based on an injection pathway model that defines injection point locations and a number of injection pathway directions from each point.
    Type: Application
    Filed: January 8, 2013
    Publication date: May 23, 2013
    Applicant: ALLERGAN, INC.
    Inventor: Allergan, Inc.
  • Patent number: 8439895
    Abstract: A directionally limited illuminating balloon catheter includes a multi-lumen shaft having a distal end and a hollow balloon portion disposed at the distal end and inflated through the shaft, the balloon portion having a light source illuminating only a portion of the environment outside the balloon portion. The balloon portion can have a directionally limited light source directing substantially all illumination towards the shaft. Also provided is a directionally illuminating balloon catheter kit including a set of illuminating catheters each having the light source with different sized illuminating areas to illuminate a different sized partial portion of the environment outside the balloon portion.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: May 14, 2013
    Inventors: Gary M. Kalser, Gregory L. Mayback
  • Patent number: 8366705
    Abstract: A cardiac ablation instrument capable of removing blood from a treatment area is provided. The instrument includes a catheter configured to deliver a distal end thereof to a patient's heart. The instrument can also include an expandable element coupled to the distal end of the catheter wherein the expandable member is configured to be positioned adjacent a target area thereby defining a treatment area between the expandable member and the target area. Further, the instrument can include an irrigation mechanism configured to dispense an irrigation fluid from the catheter thereby displacing blood from the treatment area. Additionally, the instrument includes an energy emitter configured to deliver energy to tissue within the treatment area. The instrument can also include a contact sensor configured to determine the presence of such blood within the treatment area. Methods for ablating tissue are also provided.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 5, 2013
    Assignee: Cardiofocus, Inc.
    Inventors: Jeffrey M. Arnold, Edward L. Sinofsky, Lincoln S. Baxter, Norman E. Farr
  • Patent number: 8251983
    Abstract: A laser tissue fusion device is optimized for particular surgical applications to join tissue layers. The device has two opposed arms that engage and disengage to clamp and release layers of tissue therebetween. The distal end of the first arm is disposed opposite the distal end of the second arm. A laser energy source generates therapeutic laser energy is either integrated within the device is a separate unit. An energy pathway transmits the laser energy to the distal end of the first arm to deliver the laser energy to tissue layers clamped between the distal ends of the arms. An actuator decreases the separation distance between the distal ends of the arms to clamp the tissue layers and activates the laser energy source upon engagement. The laser energy source delivers a burst of energy at a predetermined wavelength for a predetermined period of time sufficient to spot weld the tissue.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: August 28, 2012
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Michael Larson, Jesse McClure, Luke Hooper
  • Patent number: 8246667
    Abstract: This invention concerns a system for dermatological treatment including an energy source suitable for biochemically activating healing and including at least one means of interaction between the energy source and the patient. The means of interaction is composed of a continuous adhesive support suitable for placement close to the area to be treated, the support having a means of identification and interacting without contact with a sensor allowing the energy source to function only when the distance between the sensor and the means of identification is less than a threshold value. The invention also concerns such a continuous adhesive support and a method of dermatological treatment.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: August 21, 2012
    Assignee: EKKYO
    Inventors: Alain Cornil, Alexandre Capon, Alban Gosse, Patrick Peronne
  • Patent number: 8162960
    Abstract: A radical prostatectomy anastomosis device including a cartridge having a plurality of anchors slidably disposed in a plurality of distally angled radial channels formed in the cartridge and a pusher assembly operatively coupled within the cartridge. The pusher assembly being configured and adapted to push each of the plurality of anchors out of the angled radial channels of the radial cartridge. The device further including a fitting removably coupled to a distal end of the cartridge. The fitting including a flange having a plurality of holes formed radially around the flange, wherein each of the plurality of holes includes suture locking means configured and adapted to permit a suture to be drawn distally through each of the plurality of holes and to prevent the sutures from being drawn proximally through each of the plurality of holes. The device further including a plurality of sutures secured to an inner surface of the cartridge.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: April 24, 2012
    Assignee: Tyco Healthcare Group LP
    Inventor: Scott E. Manzo
  • Publication number: 20120035527
    Abstract: The exemplary embodiments of the present invention provides exemplary methods for adhering biological membranes to luminal anatomical structures using photosensitizing agents and electromagnetic energy. The exemplary embodiments of the present invention also provides method for stabilizing luminal anatomical structures. Further, exemplary embodiments of the present invention provide arrangements for coupling to a luminal anatomical structure.
    Type: Application
    Filed: October 2, 2008
    Publication date: February 9, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Guillermo Tearney, Brett Bouma, Robert W. Redmond, Irene E. Kochevar
  • Patent number: 8021362
    Abstract: Methods and apparatus for treatment of layered tissue defects having a majority of the surfaces of the defect layers in contact generally involve use of a catheter having at least one energy transmission member at its distal end. The distal end of the apparatus also typically has a force applying member which can apply a force to the tissue defect. Often this force is a lateral force or vacuum which helps the tissue to appose itself. An exemplary method of closing a patent foramen ovale (PFO) involves positioning a closure device between layers of the PFO. Energy is then applied to the layered tissue defect with the closure device so as to substantially close the tissue defect. The energy is often monopolar or bipolar radiofrequency energy. A force may also be applied by the closure device to the layered tissue defect so as to bring the layered tissue defect together.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: September 20, 2011
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Mark E. Deem, Erik Engelson, Dominique Filloux, Dan Francis, Hanson Gifford, Kenneth Horne, Uday N. Kumar, William Malecki, Miriam H. Taimisto
  • Publication number: 20110130747
    Abstract: A device and method for endovascular radiation therapy that prevents unwanted damage to blood vessels during treatment is described. One feature is a means for preventing the emission end of an energy delivery device from coming into contact with the wall of a blood vessel. This positioning means may be a distancing catheter or ring incorporated into a catheter. Another feature is a sensing means that senses the inputted radiation power and prevents irradiation above a preselected power or energy level. Both features serve to prevent radiation, having an overly high intensity or power density, from impacting the vessel wall and causing a puncture.
    Type: Application
    Filed: November 22, 2010
    Publication date: June 2, 2011
    Inventor: Wolfgang Neuberger
  • Publication number: 20100249763
    Abstract: A laser tissue fusion device is optimized for particular surgical applications to join tissue layers. The device has two opposed arms that engage and disengage to clamp and release layers of tissue therebetween. The distal end of the first arm is disposed opposite the distal end of the second arm. A laser energy source generates therapeutic laser energy is either integrated within the device is a separate unit. An energy pathway transmits the laser energy to the distal end of the first arm to deliver the laser energy to tissue layers clamped between the distal ends of the arms. An actuator decreases the separation distance between the distal ends of the arms to clamp the tissue layers and activates the laser energy source upon engagement. The laser energy source delivers a burst of energy at a predetermined wavelength for a predetermined period of time sufficient to spot weld the tissue.
    Type: Application
    Filed: May 14, 2008
    Publication date: September 30, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Michael C. Larson, Jesse McClure, Luke Hooper
  • Patent number: 7789848
    Abstract: Methods and devices for use in tissue approximation and fixation are described herein. The present invention provides, in part, methods and devices for acquiring tissue folds in a circumferential configuration within a hollow body organ, e.g., a stomach, positioning the tissue folds for affixing within a fixation zone of the stomach, preferably to create a pouch or partition below the esophagus, and fastening the tissue folds such that a tissue ring, or stomas, forms excluding the pouch from the greater stomach cavity. The present invention further provides for a liner or bypass conduit which is affixed at a proximal end either to the tissue ring or through some other fastening mechanism. The distal end of the conduit is left either unanchored or anchored within the intestinal tract. This bypass conduit also includes a fluid bypass conduit which allows the stomach and a portion of the intestinal tract to communicate.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: September 7, 2010
    Assignee: Satiety, Inc.
    Inventors: Jamy Gannoe, Craig Gerbi, Gary Weller, Matthew J. Collier
  • Patent number: 7762445
    Abstract: An electrosurgical stapling apparatus is provided which uses thermogenic energy as well as surgical fasteners or staples for strengthening tissue, providing hemostasis, tissue joining or welding. The thermogenic energy also strengthens tissue in proximity to a staple line and knife cut line and provides hemostasis along the staple and cut lines formed by the staples and a knife blade during surgical stapling. The use of thermogenic energy provides short-term hemostasis and sealing, and reduces or prevents staple line and cut line bleeding, while the stapling features provide short and long-term tissue strength and hemostasis. The stapling apparatus further substantially reduces or prevents knife cut line bleeding by energizing a knife blade for cauterizing tissue while it is being cut. In one embodiment, energy is applied to the anvil to energize the staples as they make contact with the anvil.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: July 27, 2010
    Assignee: Tyco Healthcare Group LP
    Inventors: Russell Heinrich, Frank J. Viola
  • Patent number: 7749280
    Abstract: A urethral prosthesis with prostatic and bulbar segments connected by two types of ties allows the prosthesis to assume at least two configurations different with inter-segmental distances adapted to situations where the patient either has or does not have normal control of the external sphincter. This is particularly useful for a patient undergoing an anesthetic procedure that affects the external sphincter muscles. When the muscles are anesthetized, the prosthesis may provide constant urine voiding, and when the anesthetic effects wear off, the prosthesis may assume a different configuration to allow the sphincter to reassert control over urinary voiding.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: July 6, 2010
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Robert F. Rioux, Christopher R. O'Keefe
  • Patent number: 7704247
    Abstract: Consistent with the present invention, a tube is provided that contains both a sensing and a laser delivery fiber to the target area. The length of the tube can be varied to any desired length. The end portion of the tube includes a second piece, which is a cap having two through holes or passages. These holes can be formed by standard machining or micromaching methods. The first hole can accommodate the sensing fiber, while the second hole contains the laser delivery fiber. The first and second holes extend in first and second directions, respectively, and form an angle therebetween such that the sensor fiber viewing area is within the radiation area created by the laser delivery fiber. Accordingly, the sensor fiber receives energy emitted from a central portion of the radiation area so that the temperature of the exposed tissue can be accurately determined.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: April 27, 2010
    Inventors: Barbara Ann Soltz, Robert Soltz, Michael Andrew Soltz
  • Publication number: 20100063489
    Abstract: This invention concerns a system for dermatological treatment including an energy source suitable for biochemically activating healing and including at least one means of interaction between the energy source and the patient. The means of interaction is composed of a continuous adhesive support suitable for placement close to the area to be treated, the support having a means of identification and interacting without contact with a sensor allowing the energy source to function only when the distance between the sensor and the means of identification is less than a threshold value. The invention also concerns such a continuous adhesive support and a method of dermatological treatment.
    Type: Application
    Filed: January 29, 2008
    Publication date: March 11, 2010
    Applicant: EKKYO
    Inventors: Alain Cornil, Alexandre Capon, Alban Gosse, Patrick Peronne
  • Publication number: 20090287194
    Abstract: The invention provides a device and method for illuminating a body surface. A light source is optically coupled to the proximal end of a light guide and a light scatterer is optically coupled to the distal end of the light guide. The device includes a deployment mechanism that is configured to bring the light scatterer from a small caliber configuration in which the light scatterer is delivered to the body surface to a large caliber configuration in which the light scatterer irradiates the body surface. The invention may be used, for example, irradiate the periadventitial surface of an aneurysmal blood vessel.
    Type: Application
    Filed: April 10, 2007
    Publication date: November 19, 2009
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: David Gertz, Lilach Gavish, Petachia Reissman
  • Patent number: 7535935
    Abstract: A laser system for a spectroscopic catheter system uses multiple semiconductor gain media having gain peaks at different wavelengths. The output from the gain media is preferably coupled into single-mode fiber using conventional opto-electronic packaging techniques. As a result, the laser oscillator source has a spectral output that is wider than the gain bandwidth of a single medium to enable it to access the entire spectrum of interest, which is presently in the near infrared. Moreover, the semiconductor gain media can be packaged in a stable and controlled environment for long-term performance.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: May 19, 2009
    Assignee: InfraReDx, Inc.
    Inventor: Jeffrey A. Korn
  • Patent number: 7320710
    Abstract: A urethral prosthesis with prostatic and bulbar segments connected by two types of ties allows the prosthesis to assume at least two configurations different with inter-segmental distances adapted to situations where the patient either has or does not have normal control of the external sphincter. This is particularly useful for a patient undergoing an anesthetic procedure that affects the external sphincter muscles. When the muscles are anesthetized, the prosthesis may provide constant urine voiding, and when the anesthetic effects wear off, the prosthesis may assume a different configuration to allow the sphincter to reassert control over urinary voiding.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: January 22, 2008
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Robert F. Rioux, Christopher R. O'Keefe
  • Patent number: 7229428
    Abstract: A bypass conduit assembly is placed in a hollow body organ to route food and liquids past the hollow body organ. A flexible tubular member extends from a narrowed section through the hollow body organ and into either the pylorus or intestines. The tubular member is connected to tissue by fasteners such as clips, staples or stents.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: June 12, 2007
    Assignee: Satiety, Inc.
    Inventors: Jamy Gannoe, Craig Gerbi, Gary Weller
  • Patent number: 7220237
    Abstract: Methods and devices for use in tissue approximation and fixation are described herein. The present invention provides, in part, methods and devices for acquiring tissue folds in a circumferential configuration within a hollow body organ, e.g., a stomach, positioning the tissue folds for affixing within a fixation zone of the stomach, preferably to create a pouch or partition below the esophagus, and fastening the tissue folds such that a tissue ring, or stomas, forms excluding the pouch from the greater stomach cavity. The present invention further provides for a liner or bypass conduit which is affixed at a proximal end either to the tissue ring or through some other fastening mechanism. The distal end of the conduit is left either unanchored or anchored within the intestinal tract. This bypass conduit also includes a fluid bypass conduit which allows the stomach and a portion of the intestinal tract to communicate.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: May 22, 2007
    Assignee: Satiety, Inc.
    Inventors: Jamy Gannoe, Craig Gerbi, Gary Weller, Matthew J. Collier
  • Patent number: 7105011
    Abstract: A method of achieving tissue changes in bone or bone-derived organic tissue, in which method bone or bone-derived organic tissue is provided, an interfacing agent is applied to the bone or bone-derived organic tissue, and electromagnetic energy is applied to the interfacing agent. The interfacing agent can include collagen, preferably bone-derived collagen, and a therapeutic agent. In a related embodiment, a method of treating bone tissue is provided wherein a bioactive interfacing agent is placed between the bone segments of the bone tissue to be treated.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: September 12, 2006
    Inventor: Wayne K. Auge, II
  • Patent number: 7077839
    Abstract: Various tissue glues have drawback such as toxicity, causing inflammatory reactions or insufficient bonding strength. The present invention is directed to methods of form tissue adhesion by administering to tissues compositions comprising proteins conjugated to one or more novel photosensitizers and irradiating the composition. The composition may further comprise one or more proteins not conjugated to the photosensitizer. Additionally, the present invention relates to compositions and methods wherein increased ratios of protein to photosensitizer enhance weld strength.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: July 18, 2006
    Assignee: General Hospital Corporation
    Inventors: Michael R. Hamblin, John Khadem
  • Patent number: 7033348
    Abstract: Laser tissue welding can be achieved using tunable Cr4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: April 25, 2006
    Assignee: The Research Foundation of The City University of New York
    Inventors: Robert R. Alfano, Jing Tang, Jonathan M. Evans, Peng Pei Ho
  • Patent number: 6855139
    Abstract: An automated energy irradiator guidance system is disclosed which reduces the potential for human error and improves the consistency and repeatability of tissue welding techniques. The system includes a mapper, a patternizer, an energy director and can additionally include an energy regulator. An interface is included, allowing pattern creation, selection and editing by a user. The system further provides control of energy irradiator parameters for use in tissue welding.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: February 15, 2005
    Assignees: Providence Health System-Oregon
    Inventors: Karen Marie Ahle, Brooke C. Basinger, Jason De Camp, Kenton W. Gregory, Elizabeth Whitney Johansen, Benjamin Charles Martin, Cyndia A. Sweet
  • Patent number: 6829260
    Abstract: A method for generating a long effective pulse duration output beam of laser radiation using a flashlamp-excited dye laser is described. A spaced series of excitation pulses is electronically generated using a pulse forming module. The series of excitation pulses are provided to a flashlamp-excited dye laser, which generates an output beam of laser radiation. The output beam is comprised of a series of spaced micropulses of laser radiation which, in combination, provide a long effective pulse duration.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 7, 2004
    Assignee: Candela Corporation
    Inventors: James C. Hsia, Anthony D. Quaglia, Charles Johnson, Mike Clancy
  • Publication number: 20040181210
    Abstract: A method for firming and removing cellulite comprising: exfoliating an area of a body for treatment of the cellulite; applying an anti-cellulite/firming agent to the area of a body for treatment of the cellulite; and administering light treatment to the area of a body for treatment of the cellulite.
    Type: Application
    Filed: March 10, 2003
    Publication date: September 16, 2004
    Inventor: Jeremy J. Shellman
  • Publication number: 20040176752
    Abstract: A system and method for exposing ocular tissue to a beam of electromagnetic radiation tuned to an NIR wavelength between about 1380 nm and about 1600 nm in the water absorption band. The laser energy is absorbed by the water, which in turn, transfers the energy to collagen molecules. The helical collagen molecules partially denature and then re-nature to form a weld across the region of the tissues to be joined. In a preferred embodiment, the electromagnetic radiation originates from a laser. The lasers may be Cr4+ doped crystals, Erbium fibers, and alloys of semiconductor laser diodes.
    Type: Application
    Filed: March 6, 2003
    Publication date: September 9, 2004
    Inventors: Robert R. Alfano, Tapan K. Gayen, Steven A. McCormick, Richard B. Rosen, Alvin Katz, Howard E. Savage
  • Patent number: 6783541
    Abstract: A method for inhibiting or suppressing stenosis associated with an arteriovenous access. A dosage of photosensitive compound is introduced into the artery or vein. An anastomotic area of the artery or vein is then exposed to a source of light having a wavelength suitable for photoactivating the photosensitive compound for a period of time sufficient to provide a therapeutic effect. A method is also described for the delivery of drugs into the anastomotic site of an AV access to inhibit the formation of stenotic lesions at those sites.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: August 31, 2004
    Assignee: Miravant Medical Technologies, Inc.
    Inventors: W. Patrick Stephens, Steven John Rychnovsky, Jeffrey P. Walker, Heidi Nielsen, Christina Ann Waters, John S. Hill
  • Patent number: 6692517
    Abstract: A method for the reduction in healing time for a wound on the skin of a mammalian patient. The method comprises the steps of providing an optical radiation apparatus with a handpiece communicating therewith, energyzing the optical radiation apparatus to provide a beam of light, and directing the light beam onto a wound or surgical site of a patient. The beam has a wavelength range of about 530 nm to 1000 nm and the beam has a fluence range of from 2 J/cm2 to 5 J/cm2. The beam is preferrably generated by a pulse dye laser apparatus.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: February 17, 2004
    Assignee: Cynosure, Inc.
    Inventors: George Cho, Horace Furumoto, Rafael A Sierra
  • Patent number: 6676655
    Abstract: Disclosed is a method for treating various dermatalogical conditions using electromagnetic radiation. Particularly preferred are narrowband, multichromatic electromagnetic radiation emitters having a dominant emissive wavelength corresponding to the peak absorption wavelength of the mammalian tissue targetted for treatment. Topical compositions are disclosed for pretreating the targetted tissue to alter the peak absorption wavelength of the tissue.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: January 13, 2004
    Assignee: Light BioScience L.L.C.
    Inventor: David H. McDaniel
  • Patent number: 6667051
    Abstract: The invention is directed to a method including the steps of providing at least one layer of unlaminated elastin or unlaminated elastin-based materials or unlaminated tropoelastin materials. Then, the unlaminated elastin or unlaminated elastin-based materials or unlaminated tropoelastin materials is subjected to heating and pressing steps. The pressing step of the present invention is preferably conducted in the presence of steam. The laminated elastin or laminated elastin-based materials or laminated tropoelastin materials preferably comprises a multi-layer composite material. Typically, the step of adhering with an adhesive material the laminated elastin or laminated elastin-based materials or laminated tropoelastin materials is employed in order to achieve a water-tight engagement with the tissue substrate. A biogradable cyanacrylate glue is generally used in order to achieve quick and easy way to secure the patch in place and provide watertight fusion instantly.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: December 23, 2003
    Assignees: Providence Health System-Oregon
    Inventor: Kenton W. Gregory
  • Publication number: 20030216718
    Abstract: Various tissue glues have drawback such as toxicity, causing inflammatory reactions or insufficient bonding strength. The present invention is directed to methods of form tissue adhesion by administering to tissues compositions comprising proteins conjugated to one or more novel photosensitizers and irradiating the composition. The composition may further comprise one or more proteins not conjugated to the photosensitizer. Additionally, the present invention relates to compositions and methods wherein increased ratios of protein to photosensitizer enhance weld strength.
    Type: Application
    Filed: June 16, 2003
    Publication date: November 20, 2003
    Inventors: Michael R. Hamblin, John J. Khadem
  • Publication number: 20030204182
    Abstract: An automated energy irradiator guidance system is disclosed which reduces the potential for human error and improves the consistency and repeatability of tissue welding techniques. The system includes a mapper, a patternizer, an energy director and can additionally include an energy regulator. An interface is included, allowing pattern creation, selection and editing by a user. The system further provides control of energy irradiator parameters for use in tissue welding.
    Type: Application
    Filed: April 24, 2002
    Publication date: October 30, 2003
    Applicant: Providence Health System- Oregon an Oregon Corporation
    Inventors: Karen Marie Ahle, Brooke C. Basinger, Jason De Camp, Kenton W. Gregory, Elizabeth Whitney Johansen, Benjamin Charles Martin, Cynthia A. Sweet
  • Patent number: 6638272
    Abstract: A delivery guide frame attachment for a laser scanner mechanism for a laser treatment operation, to permit proper spacing and dimensional stability of the laser scanner with respect to the skin of a patient being treated. The delivery guide frame attachment includes a housing having an upper end and a lower end. The lower end is applyable to the skin of a patient. The upper end is attached to the laser scanner. A chilled fluid supply conduit is arranged in communication with the housing for delivering a chilled fluid onto the skin of a patient when the housing is applied thereto. A chilled fluid containment arrangement in the housing retains and delays escape of chilled fluid from the housing placed on the patient, for a short period during the laser treatment operation.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: October 28, 2003
    Assignee: Cynosure, Inc
    Inventors: George Cho, Anthony P. Burns
  • Patent number: 6607522
    Abstract: Various tissue glues have drawback such as toxicity, causing inflammatory reactions or insufficient bonding strength. The invention is directed to methods of form tissue adhesion by administering to tissues compositions comprising proteins conjugated to one or more novel photosensitizers and irradiating the composition. The composition may further comprise one or more proteins not conjugated to the photosensitizer. Additionally, the present invention relates to compositions and methods wherein increased ratios of protein to photosensitizer enhance weld strength.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: August 19, 2003
    Assignee: General Hospital Corporation
    Inventors: Michael R. Hamblin, John Khadem
  • Patent number: 6604847
    Abstract: A portable reading light device utilizing an LEDs as the source of light mounted in a housing having a single lens through which light from the LEDs is projected, the power to the LEDs being controlled by Pulse Width Modulation.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: August 12, 2003
    Inventor: Robert A. Lehrer
  • Patent number: 6583117
    Abstract: A method for joining tissue comprising aligning and abutting edges of the tissue to be joined applying a biodegradable, biological solder or an analogue thereof, across the edges and exposing the solder to an energy source under conditions which provide transfer of energy from the source to the solder to cause the solder to bond to the tissue surface adjacent the edges to provide a weld holding the edges together.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: June 24, 2003
    Assignees: The Microsearch Foundation of Australia, Macquarie Research Ltd.
    Inventors: Earl Ronald Owen, Rodney Ian Trickett, Antonio Lauto, Judith Margaret Dawes, James Austin Piper
  • Patent number: 6579311
    Abstract: Devices, systems and methods for transvascular interstitial interventions, including transvascular, catheter based vascular bypass, transmyocardial revascularization, bypass grafting of blood vessels, and interstitial surgical/interventional procedures wherein a catheter is advanced translumenally through the vasculature to a desired location and an operative instrument is passed through the wall of a blood vessel and to a target location (e.g. another blood vessel, an organ, a tumor, another anatomical structure) such that one or more operative devices may be advanced to the target location to perform the desired operative or interventional procedure.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: June 17, 2003
    Assignee: TransVascular, Inc.
    Inventor: Joshua Makower
  • Publication number: 20030093092
    Abstract: This invention is generally in the field of improved methods for the localized delivery of heat and the use thereof for the repair of tissue. The method involves localized induction of hyperthermia in tissue or materials by delivering nanoparticles to the tissue or materials and exposing the nanoparticles to an excitation source under conditions wherein they emit heat. The generation of heat effects the joining of the tissue or materials.
    Type: Application
    Filed: September 25, 2002
    Publication date: May 15, 2003
    Inventors: Jennifer L. West, Rebekah Drezek, Scott Sershen, Nancy J. Halas
  • Patent number: 6562025
    Abstract: The apparatus for uniting the lips of a wound comprises a laser having an emission wavelength chosen such that it can perform tissue bonding and unite the lips of a wound, and a holding piece suitable for being secured to the tissue around the wound so as to keep the lips of the wound approximated, at least while the wound is being exposed to said laser radiation, the holding piece including at least one region suitable for being positioned over the wound and sufficiently transparent at the wavelength of the laser radiation for the energy from said radiation to be sufficient, after it has passed through said region, to perform the desired tissue bonding.
    Type: Grant
    Filed: July 22, 1999
    Date of Patent: May 13, 2003
    Assignee: Galderma Research & Development, S.N.C.
    Inventors: Serge R. Mordon, Alexandre Capon, Chryslain Sumian