Internal Application Patents (Class 607/113)
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Patent number: 8231664Abstract: Relatively non-invasive devices and methods for heating or cooling a patient's body are disclosed. Devices and methods for treating ischemic conditions by inducing therapeutic hypothermia are disclosed. Devices and methods for inducing therapeutic hypothermia through esophageal cooling are disclosed. Devices and methods for operative temperature management are disclosed.Type: GrantFiled: February 26, 2010Date of Patent: July 31, 2012Assignee: Advanced Cooling Therapy, LLCInventors: Erik Kulstad, Hugh Patrick Caherty
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Patent number: 8224455Abstract: A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.Type: GrantFiled: October 12, 2010Date of Patent: July 17, 2012Assignee: Boston Scientific CorporationInventors: John Mon, Alan J. Fenn
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Patent number: 8216153Abstract: A cryosurgical instrument for separating a tissue sample from a biological tissue to be treated, for purposes of biopsy. The cryosurgical instrument includes a probe for bringing a probe head up to the biological tissue and a gas line for supplying cooling gas from a gas source of a cryosurgical apparatus to the probe head. The probe head cools a limited tissue region, by means of the supplied gas, for obtaining a tissue sample. The tissue sample can be separated from the surrounding tissue when frozen onto the probe head. The instrument has a support tube in which the probe is guided and which can be moved relative to the probe in such a way that the surrounding tissue can be supported by means of the support tube during the separating of the tissue sample. The instrument also includes an accelerating device that provides a predefined force for the separating process.Type: GrantFiled: June 20, 2008Date of Patent: July 10, 2012Assignee: ERBE Elektromedizin GmbHInventors: Klaus Fischer, Mara Szyrach, Daniel Schäller, Matthias Voigtländer, Irina Sigle
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Publication number: 20120158105Abstract: Methods are described for augmenting cerebral blood flow and altering sympathetic nerve firing and catecholamine release by cooling a part of the body. In particular localized cooling of the nose or mouth is used to augment cerebral blood flow and alter sympathetic nerve firing. By cooling a localized area such as nose or mouth, release of norepinephrine after an ischemic event is inhibited. The methods described may be applied to augment cerebral blood flow and alter catecholamine release, particularly in treatment of stroke, heart attack and transient ischemic event.Type: ApplicationFiled: December 20, 2011Publication date: June 21, 2012Applicant: BeneChill Inc.Inventors: Denise Barbut, Wanchung Tang
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Patent number: 8202308Abstract: A depth cooling implant system having a probe device implanted inside a targeted area of the brain, such as the medial temporal lobe, for the treatment of epilepsy is disclosed. The probe device includes a heat pipe having a sensor for detecting the temperature of surrounding brain tissue as well as a plurality of recording electrodes for monitoring EEG activity of the brain. Further, the heat pipe defines a proximal portion in operative engagement with a cooling chip that provides a nearly instantaneous cooling effect to the heating pipe in order to immediately cool the targeted area of the brain when an epileptic seizure is detected. The probe device is operatively associated with a probe controller having a computer and battery arrangement that may be implanted in the patient in order to monitor brain activity and selectively activate the cooling chip for cooling the medial temporal lobe in response to an epileptic seizure.Type: GrantFiled: June 30, 2008Date of Patent: June 19, 2012Inventor: Matthew D. Smyth
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Publication number: 20120143293Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: October 25, 2011Publication date: June 7, 2012Inventors: Kevin Mauch, Mario Alvarado, Robert Beetel, William Chang, Justin Goshgarian, Leonila Rivera, Sukyoung Shin, Michele Silver, Sina Som, Andrew Wu, Denise Zarins, Juanita Sanchez-Cole, Maria G. Aboytes
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Publication number: 20120130289Abstract: Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.Type: ApplicationFiled: January 30, 2012Publication date: May 24, 2012Applicant: Ardian, Inc.Inventors: Denise Demarais, Hanson Gifford, III, Mark Deem, Douglas Sutton, Howard R. Levin, Mark Gelfand
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Publication number: 20120130458Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: October 23, 2011Publication date: May 24, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Eric Ryba, Denise Zarins
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Patent number: 8167923Abstract: Methods are described for augmenting cerebral blood flow and altering sympathetic nerve firing and catecholamine release by cooling a part of the body. In particular localized cooling of the nose or mouth is used to augment cerebral blood flow and alter sympathetic nerve firing. By cooling a localized area such as nose or mouth, release of norepinephrine after an ischemic event is inhibited. The methods described may be applied to augment cerebral blood flow and alter catecholamine release, particularly in treatment of stroke, heart attack and transient ischemic event.Type: GrantFiled: October 13, 2009Date of Patent: May 1, 2012Assignee: BeneChill Inc.Inventors: Denise Barbut, Wanchung Tang
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Publication number: 20120101538Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: October 25, 2011Publication date: April 26, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Sowmya Ballakur, Robert Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 8163000Abstract: A guidable catheter for heating or cooling fluid in a feeding vessel in a vasculature of a patient includes a heat transfer element having exterior surface irregularities to create turbulence in a surrounding fluid. A supply catheter delivers a working fluid to an interior of the heat transfer element, and a return catheter returns a working fluid from the interior of the heat transfer element. A guidewire tube is provided adjacent one of the supply catheter or the return catheter and runs substantially parallel to the axis of the guidable catheter to receive a guidewire disposed within the guidewire tube. A temperature-monitoring device is disposed at the distal tip of the guidewire. Feedback is provided to control the temperature of a source of working fluid.Type: GrantFiled: November 13, 2007Date of Patent: April 24, 2012Assignee: Innercool Therapies, Inc.Inventors: John D. Dobak, III, Juan C. Lasheras, Randell L. Werneth
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Patent number: 8157767Abstract: A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.Type: GrantFiled: June 18, 2010Date of Patent: April 17, 2012Assignee: BeneChill, Inc.Inventors: Allan Rozenberg, John K Hoffman, James Savage
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Publication number: 20120089211Abstract: A method for cryogenically treating tissue comprises piercing the skin, inserting a sheath into tissue, and passing a cryoprobe through the sheath into the tissue. The cryoprobe cools a first region of the tissue, is repositioned in the sheath, and then cools a second region of the tissue.Type: ApplicationFiled: April 8, 2011Publication date: April 12, 2012Applicant: Myoscience, Inc.Inventors: Robert M. Curtis, Phillip Olsen
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Publication number: 20120078377Abstract: A system, device and method for dilating an anatomical structure. Systems, devices and methods may comprise a therapeutic component configured to treat a paranasal sinus. Specific embodiments may use high frequency pressure waves and/or cryogenic temperatures.Type: ApplicationFiled: September 23, 2011Publication date: March 29, 2012Applicant: ENTRIGUE SURGICAL, INC.Inventors: Donald A. Gonzales, Fred B. Dinger, III, Prasad Nalluri
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Publication number: 20120041525Abstract: Disclosed are methods for dermatological treatment that in some embodiments include contacting a plurality of cooling probes with an area of skin and maintaining the plurality of cooling probes in contact with the area of skin for a period of time while the distal ends of the plurality of cooling probes substantially cool a volume of tissue, thereby causing a beneficial effect as a result of the substantial cooling of the volume of tissue, as well as devices useful for implementing the method.Type: ApplicationFiled: April 28, 2010Publication date: February 16, 2012Applicant: ALMA LASERS LTD.Inventor: Ziv Karni
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Publication number: 20120035583Abstract: Deep Brain Stimulation (DBS) is taking off and will be part of the main treatment for brain diseases such as movement disorders, epilepsy, psychiatric diseases and many others. There is a need for more sophisticated devices that can do more in one penetration, not just stimulate. Once there is a probe in the brain, it is used for multiple passive measurements, without harming the brain further. It provides better understanding the brain and real time closed loop improved treatment. An apparatus and method are disclosed, which allow simultaneous monitoring of multiple parameters inside the human brain, such as: pH, temperature, pressure, seizure activity (EEG), degree of metabolism, oxygen tension in the brain, degree of excitotoxicity and others. The ability to measure those parameters during treatment and stimulation procedures makes the difference between success and failure of the patient.Type: ApplicationFiled: October 18, 2011Publication date: February 9, 2012Inventor: Jehuda Peter Sepkuty
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Patent number: 8109894Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 4, 2011Date of Patent: February 7, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CaliforniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Publication number: 20120029408Abstract: A system, apparatus and methods are provided for extra-corporeal blood treatment, and in particular for establishing and maintaining a neck down differential body temperature, while maintaining near normal brain temperatures, to protect the brain from extended or extreme hypothermia or hyperthermia. A blood treatment apparatus and system is provided for differential control of brain temperature and body temperature below the neck. For example, a first bypass circuit with heat exchanger for brain blood circulation maintains a near normal blood temperature, while a second bypass circuit for below the neck blood circulation provides for thermal treatment to induce a temperature differential, e.g. hyperthermia or hypothermia, relative to brain circulation. Such systems and apparatus have application, for example, for diagnostic and therapeutic treatments using hyperthermia, particularly for treatments of extended duration or at elevated temperatures above 42° C.Type: ApplicationFiled: March 30, 2010Publication date: February 2, 2012Inventor: Steve Andre Beaudin
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Publication number: 20120029494Abstract: An intravascular catheter is provided, including a flexible elongate body; an expandable element positioned on the elongate body; a substantially linear thermal segment located distally of the expandable element; a first fluid flow path in fluid communication with the expandable element; and a second fluid flow path in fluid communication with the substantially linear thermal segment.Type: ApplicationFiled: July 28, 2010Publication date: February 2, 2012Applicant: MEDTRONIC CRYOCATH LPInventors: Dan WITTENBERGER, Ioana Alina DEAC, Jean-Pierre LALONDE, Deborah A. DE ROY
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Patent number: 8105262Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 3, 2011Date of Patent: January 31, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CaliforniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Patent number: 8105264Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 4, 2011Date of Patent: January 31, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CalifoniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worchen, Yves Pierre Gobin
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Patent number: 8105263Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: February 3, 2011Date of Patent: January 31, 2012Assignees: Zoll Circulation, Inc., The Regents of the University of CaliforniaInventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Publication number: 20110313499Abstract: An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.Type: ApplicationFiled: December 16, 2010Publication date: December 22, 2011Inventors: Lanty L. Smith, Lesco L. Rogers
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Patent number: 8082043Abstract: A percutaneous method treats degenerate disc disease characterized by a circumferential bulge. The method provides a catheter having a distal end, a proximal end, and a longitudinal axis, the distal end having an intradiscal section with at least one energy delivery device. The next step is applying a force longitudinally to the proximal end of the catheter which is sufficient to advance the intradiscal section through a nucleus pulposus and around an inner wall of an annulus, but which force is insufficient for the intradiscal section to puncture the annulus fibrosus. Next the energy delivery device is positioned at a selected location of the annulus by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. The thermal energy delivery device is positioned adjacent the annulus and used to heat and stiffen the disc. Optionally, there is an additional step of adding a substance to reinforce the area.Type: GrantFiled: October 31, 2007Date of Patent: December 20, 2011Assignee: Neurotherm, Inc.Inventors: Hugh R. Sharkey, Joel Saal, Jeffrey Saal, John Ashley
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Patent number: 8075605Abstract: Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about ?20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports.Type: GrantFiled: June 28, 2010Date of Patent: December 13, 2011Assignee: BeneChill, Inc.Inventors: Denise Barbut, Allan Rozenberg
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Publication number: 20110245902Abstract: The invention is directed toward a non-chemical method of relieving motion sickness that first includes the step of refrigerating an enhanced earplug. The enhanced earplug has a first portion having a handle and connector. The second portion having a first end and a corresponding second end where the first end is affixed to the first portion through the connector. This second portion also includes a deformable bladder having a cavity and a quantity of coolant maintained within the deformable bladder. The second step is to insert the enhanced earplug into a user's ear canal through use of the handle. The third step is to cool the vestibular system of the user placing the coolant close to the ear drum. A fourth step includes removing the enhanced earplug. These four steps are repeated as necessary prior to engaging in an event, which could cause motion sickness.Type: ApplicationFiled: March 30, 2010Publication date: October 6, 2011Inventor: Jay W. Katz
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Publication number: 20110238144Abstract: A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, denaturate the prostate. In some embodiments, the needle can ablate a continuous lobe region in the prostate parallel to the urethral wall. Another feature of the vapor delivery needle is that it can introduce a cooling fluid into the urethra during treatment. Methods associated with use of the energy delivery probe are also covered.Type: ApplicationFiled: March 25, 2011Publication date: September 29, 2011Inventors: Michael Hoey, Mark Schrom, Stephanos Paulos, Randall Beyreis
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Patent number: 8025688Abstract: An apparatus for applying thermal energy to a prostate gland, comprising a support tube having a longitudinal passageway, a power lead channeled through the longitudinal central passageway and an ultrasound crystal disposed around at least part of the support tube. The ultrasound crystal is coupled to the power lead which provides the power to energize the ultrasound crystal and generate ultrasound energy providing thermal therapy to the prostate gland. The ultrasound crystal further includes inactivated portions for reducing ultrasound energy directed to the rectal wall of the patient. A sealant is disposed in contact with the ultrasound crystal allowing vibration necessary for efficient ultrasound energy radiation for the thermal therapy of the prostate gland.Type: GrantFiled: March 24, 2003Date of Patent: September 27, 2011Assignees: The Regents of the University of California, Dorner Medical Systems, Inc.Inventors: Chris J. Diederich, Everette C. Burdette
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Patent number: 7963977Abstract: Disclosed herein are devices and related methods for using those devices in the relieving and/or treating of pain, discomfort, and/or inflammation in the pelvic region using targeted pressure and temperature delivery. The devices and methods for using those devices to deliver targeted pressure and temperature therapy internally to patients through their rectal or vaginal cavities are disclosed.Type: GrantFiled: March 1, 2010Date of Patent: June 21, 2011Assignee: IC Relief, LLCInventor: Iliana Chea Brockman
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Patent number: 7959643Abstract: Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.Type: GrantFiled: September 2, 2004Date of Patent: June 14, 2011Assignee: ZOLL Circulation, Inc.Inventors: Michael W. Dae, Timothy R. Machold
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Patent number: 7962225Abstract: Method and apparatus for disrupting a gastric vagal nerve in the gastroesophageal region and testing the function and disruption of the vagal nerve. In one example embodiment, a treatment device applies ultrasound at a high energy level, such as high intensity focused ultrasound, to a vagal nerve to disrupt it and then ultrasound at a lower energy level to another portion of the vagal nerve, preferably further from the stomach, so as to stimulate the vagal nerve. Alternative ways to test the function or disruption of the vagal nerve involve using PCP-GABA, a pancreatic polypeptide, pressure changes inside the stomach, the gastric mucusol pH, a dye agent in the stomach, and other tests.Type: GrantFiled: August 20, 2008Date of Patent: June 14, 2011Assignee: Endovx, Inc.Inventors: William N. Aldrich, David Miller
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Publication number: 20110137248Abstract: Intravascular closed loop heat exchange catheters are used to manage temperature in burn patients.Type: ApplicationFiled: February 11, 2011Publication date: June 9, 2011Inventor: SUZANNE WINTER
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Patent number: 7955369Abstract: A catheter includes multiple primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes a resistive element located at the working end of the catheter. Separation is maintained between the leads such that each lead can individually receive power. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery. Energy is applied until the diameter of the hollow anatomical structure is reduced to the point where occlusion is achieved. In one embodiment, a balloon is inflated to place the resistive elements into apposition with a hollow anatomical structure and to occlude the structure before the application of energy. The inflated balloon impairs blood flow and facilitates the infusion of saline, or medication, to the hollow anatomical structure in order to reduce the occurrence of coagulation and to improve the heating of the structure by the catheter.Type: GrantFiled: September 8, 2008Date of Patent: June 7, 2011Assignee: Tyco Healthcare Group LPInventors: Russell Blake Thompson, Fiona Maria Sander, Vijay Kumar Dhaka, Brady David Esch
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Publication number: 20110125236Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: ApplicationFiled: February 3, 2011Publication date: May 26, 2011Inventors: WAYNE A. NODA, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Publication number: 20110125235Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: ApplicationFiled: February 3, 2011Publication date: May 26, 2011Inventors: WAYNE A. NODA, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Patent number: 7949407Abstract: This relates to methods and devices for achieving contact between the wall of a cavity or passageway and a medical device when used in tortuous anatomy.Type: GrantFiled: December 29, 2006Date of Patent: May 24, 2011Assignee: Asthmatx, Inc.Inventors: Gary S. Kaplan, Christopher J. Danek, William J. Wizeman, Timothy R. Dalbec, Noah Webster, Huy Phan
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Patent number: 7930033Abstract: A method of using a stimulation device to emit a medium to an appendicular region and/or rectal region of a user for treatment of a gastrointestinal disorder is described. The method includes placing the stimulation device into the appendicular region and/or rectal region, and delivering the medium, wherein the medium stimulates at least a portion of the enteric nervous system. Additionally, apparatus and delivery devices are disclosed.Type: GrantFiled: August 17, 2007Date of Patent: April 19, 2011Inventors: Jianfeng Chen, Yong Lei
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Publication number: 20110087314Abstract: A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C.Type: ApplicationFiled: October 5, 2010Publication date: April 14, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Chris J. Diederich, Jeffrey C. Lotz, Will H. Nau, JR., David S. Bradford
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Publication number: 20110087337Abstract: An apparatus for controlling a flow of fluid and/or other bodily matter in a lumen formed by a tissue wall of a patient's organ comprises an implantable constriction device for gently constricting (i.e. without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the flow in the lumen, and a stimulation device for stimulating the wall portion of the tissue wall. A control device controls the stimulation device to stimulate the wall portion, as the constriction device constricts the wall portion, to cause contraction of the wall portion constricted by the constriction device to further influence the flow in the lumen. The apparatus can be used for restricting or stopping the flow in the lumen, or for actively moving the fluid in the lumen, with a low risk of injuring the organ.Type: ApplicationFiled: April 12, 2010Publication date: April 14, 2011Inventor: Peter FORSELL
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Patent number: 7922752Abstract: A heat transfer device has first and second elongated, articulated segments, each having a turbulence-inducing exterior surface. A flexible joint connects the first and second elongated, articulated segments. An inner coaxial lumen is disposed within the first and second elongated, articulated segments. The inner coaxial lumen is capable of transporting a pressurized working fluid to a distal end of the first elongated, articulated segment.Type: GrantFiled: March 27, 2006Date of Patent: April 12, 2011Assignee: Innercool Therapies, Inc.Inventors: John D. Dobak, III, Juan C. Lasheras
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Patent number: 7913698Abstract: This invention relates to the treatment of a patient's lung, for example, a lung exhibiting chronic obstructive pulmonary disease (COPD) and in particular to methods and devices for affecting lung volume reduction, preferably for achieving acute or immediate lung volume reduction following treatment. The lung volume reduction is effected by delivering a condensable vapor at a temperature above body temperature to the desired regions of the patient's lung to damage tissue therein. Blood flow and air flow to the damaged tissue region is essentially terminated, rendering the target region non-functional. Alternative energy sources may be used to effect the thermal damage to the lung tissue.Type: GrantFiled: November 16, 2005Date of Patent: March 29, 2011Assignee: Uptake Medical Corp.Inventors: Robert L. Barry, Brian Cran, Dean Corcoran, Sheldon K. Lee
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Patent number: 7912554Abstract: A method is disclosed for treating an aneurysm or vascular defect by cooling a target tissue region of the aneurysm or vascular defect to a temperature below body temperature for a preselected time period. The method entails thickening, strengthening, or increasing the density of a blood vessel wall by cooling the blood vessel wall with a cryogenically cooled device. The method also includes irradiating the inner wall of a blood vessel around an aneurysm or vascular defect with various forms of energy to delay or halt aneurysm or vascular defect formation. An energy-emitting element is disposed on the distal end portion of a catheter device to be disposed proximate the aneurysm. Various forms of energy, including visible light energy, laser light energy, ultrasound, microwave and radiofrequency sources may be used to irradiate and treat the aneurysm.Type: GrantFiled: April 29, 2005Date of Patent: March 22, 2011Assignee: Medtronic CryoCath LPInventors: Leonilda Capuano, Daniel Nahon, Michael Urick, Willard W. Hennemann, Patrick Chauvet, Claudia Lückge
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Patent number: 7901402Abstract: A catheter includes a first plurality of expandable leads and a second plurality of expandable leads separate and longitudinally spaced-apart from the first plurality to deliver energy to a hollow anatomical structure, such as vein, fallopian tube, hemorrhoid, esophageal varix, to effectively ligate that structure. Each of the leads includes an electrode located at the distal end of the respective electrode lead. Polarizations of the leads may be selected to achieve the power distribution desired. Each electrode lead includes an outward bend such that when a movable sheath is moved out of contact with the leads, they expand outwardly into apposition with an inner wall of the structure to be ligated. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure.Type: GrantFiled: May 23, 2008Date of Patent: March 8, 2011Assignee: Tyco Healthcare Group, LPInventors: Christopher S Jones, Arthur W Zikorus, Mark P Parker, Brian E. Farley, Joseph M Tartaglia
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Publication number: 20110034976Abstract: A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.Type: ApplicationFiled: October 12, 2010Publication date: February 10, 2011Inventors: JOHN Mon, Alan J. Fenn
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Patent number: 7879077Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15? cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.Type: GrantFiled: February 12, 2007Date of Patent: February 1, 2011Assignee: Zoll Circulation, Inc.Inventors: Timothy R. MacHold, Wade A. Keller, Alex T. Roth, Nicole Denise Bloom
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Patent number: 7867188Abstract: A disposable warmer cartridge is used to heat fluids to be infused to the patient to prevent hypothermia in the patient. The cartridge has in its chamber a pair of spaced in parallel electrodes that have substantially the same dimension. When RF power is fed to the electrodes, an alternating electric field is generated between the electrodes to directly heat the fluid that is in the chamber. The heating of the fluid is achieved in a substantially instantaneous manner by controlling the energization of the electrodes through the distributed impedance of the electric field between the electrodes. Heat is readily controlled by modulating the RF power fed to the electrodes. Feedback to control the temperature of the fluid in the cartridge may be provided by non-contact and direct contact sensor(s).Type: GrantFiled: May 12, 2006Date of Patent: January 11, 2011Assignee: Smiths Medical ASD, Inc.Inventor: William E. Frey
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Patent number: 7857781Abstract: A catheter is adapted to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include hollow fibers which are adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. The hollow fibers enhance the surface area of contact, as well as the mixing of both the heat exchange fluid and the body fluid. The catheter can be positioned to produce hypothermia in a selective area of the body or alternatively positioned to systemically cool the entire body system.Type: GrantFiled: May 16, 2005Date of Patent: December 28, 2010Assignee: Zoll Circulation, Inc.Inventors: Wayne A. Noda, Mike L. Jones, Scott M. Evans, Blair D. Walker, William J. Worthen, Yves Pierre Gobin
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Publication number: 20100324483Abstract: A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.Type: ApplicationFiled: June 18, 2010Publication date: December 23, 2010Inventors: ALLAN ROZENBERG, John K. Hoffman, James Savage
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Publication number: 20100312318Abstract: A device for cooling the central nervous system (e.g., the brain) is disclosed that is specifically designed to provide cooling of an injured central nervous system for neuroprotective, antiepileptogenic, and/or antiepileptic treatments. In one embodiment, a portion of the cooling device is placed in a recess formed by removal of a portion of a patient's skull. An embedded heat-collecting portion of the cooling device is formed to fit in the location of the formed recess and a thermally conductive material of the heat-collecting portion is placed adjacent the dura mater to provide the desired degree of cooling. A heat-dissipating external plate is in thermal contact with the internal plate, and can be selectively sized according to a specific purpose.Type: ApplicationFiled: December 2, 2009Publication date: December 9, 2010Inventors: Raimondo D'Ambrosio, Matthew Smyth, Steven Mark Rothman, John W. Miller
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Patent number: 7846193Abstract: A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.Type: GrantFiled: August 8, 2006Date of Patent: December 7, 2010Assignee: Zoll Circulation, Inc.Inventors: Michael W. Dae, Timothy R. Machold, Wade A. Keller