Abstract: Provided is a device for microwave hyperthermia that may attach a flexible patch on the skin of a user based on a cross-section of a body tissue of the user, for example, a joint and muscle of a leg and an arm and may emit microwaves towards a plurality of points of the body tissue through the patch. The microwaves emitted toward the body tissue may have the same phase and maximum power. Accordingly, a maximum heat generation point may be generated in an area adjacent to the plurality of points. The device for microwave hyperthermia may move the maximum heat generation point by sequentially changing a phase and a direction of each of the microwaves. The device for microwave hyperthermia may uniformly distribute and maintain heat for treating pain and/or infection over the entire cross-section or a partial area. The device for microwave hyperthermia may be portable.

Abstract: The invention may be applied to selectively heat a diseased area in the lung while minimizing heating to the healthy area and surrounding tissue. This can be done by exposing the lung to an electromagnetic field causing dielectric or eddy current heating. The invention is particularly useful for treating emphysema as the diseased areas in emphysema patients have reduced blood flow. The diseased area will heat up rapidly while the healthy tissue will be cooled by the blood flow. This is particularly effective for treating emphysema because of the low mass of the lungs and the high blood flow. To avoid heating of surrounding organs the direction of the electromagnetic energy may be switched in a way it always passes through lungs but only intermittently passes through adjacent organs.

Abstract: The present invention provides improved methods and apparatus that use machine vision techniques to rapidly and automatically guide objects into desired docking configurations. The present invention is based at least in part upon using multi-depth, rotationally symmetric targets that are observed from two or more observation perspectives. By taking advantage of parallax effects associated with the multi-depth topography of the target, the apparent positions of target features in captured image information encodes position and angular alignment of the objects relative to each other in three dimensional space. The practice of the present invention provides a fast, accurate, reliable and automatic approach to achieve hard or soft docking configurations in the electron beam therapies as well as to implement real-time gating and tracking during the course of a treatment.

Abstract: An apparatus (1) far the therapeutic treatment of a user's tissue injury comprising a control unit (2), to which aft applicator (3) is connected adapted to be positioned in proximity of the tissue injury to be treated is described, said control unit (2) being configured to generate at the applicator (3) an electric field adapted to be applied on the tissue injury. The control unit (2) is also configured, to generate an air or oxygen flow which is directed to the applicator (3), and to transform at the applicator (3) the air or oxygen flow into an ozone flow adapted to be diffused and applied on the tissue injury in combination with said electric field.

Abstract: Techniques are disclosed, including methods and systems/apparatus, that can be used to treat cancerous tissue by exploiting the fact that such tissues have vascular branching with fractal descriptions and fractal dimensions, which are different from those found in normal soft tissue vascular branching. Such fractal branching of diseased tissue can produce resonances, or preferential energy absorption, when irradiated by either ultrasound and/or radio frequencies of EM energy; these resonances are not shared by the vascularization in normal soft tissue. Accordingly, one or more specific arrangements of multiband radiation (e.g., RF and/or ultrasonic) used to irradiate such diseased tissue will cause heating and possibly localized necropsy of tumor blood vessels, with little or minimal damage to surrounding healthy tissue. Embodiments can utilize ablation devices in conjunction with RF and/or ultrasonic sources.

Abstract: A device that warms a surface of a living body required to be warmed at an appropriate timing at any place indoors and outdoors or the sea without causing low temperature burns. A sheet having a heat generating function including a circuit capable of receiving electric power without contact over a sheet containing plastic or a fibrous body, a heat generating circuit, and a circuit that controls the temperature of the heat generating circuit is manufactured. The user with the sheet transmits the radio signal from the transmission device outdoors or indoors to heat the heat generating circuit on the sheet and the heat can be conducted to the skin of the user. Temperature can be automatically adjusted by the circuit for controlling the temperature of the heat generating circuit.

Abstract: A device for circulating fluid to a target site within a living body, comprises a longitudinal member including an inlet lumen supplying fluid to the target site and a return lumen withdrawing fluid from the target site, the return lumen surrounding the inlet lumen and a screen coupled to a distal end of the longitudinal member, the screen including a plurality of openings extending therethrough from a radially inner surface forming a radially outer wall of a distal portion of the return lumen to an outer surface thereof.

Abstract: Devices and methods for cooling microwave antennas are disclosed herein. The cooling systems can be used with various types of microwave antennas. One variation generally comprises a handle portion with an elongate outer jacket extending from the handle portion. A microwave antenna is positioned within the handle and outer jacket such that cooling fluid pumped into the handle comes into contact directly along a portion of the length, or a majority of the length, or the entire length of the antenna to allow for direct convective cooling. Other variations include cooling sheaths which form defined cooling channels around a portion of the antenna. Yet another variation includes passively-cooled systems which utilize expandable balloons to urge tissue away from the surface of the microwave antenna as well as cooling sheaths which are cooled through endothermic chemical reactions. Furthermore, the microwave antennas themselves can have cooling lumens integrated directly therethrough.

Abstract: A system for fragmenting material includes an energy source, an acoustic transmitter, and a controller. The acoustic transmitter is coupled to the energy source and includes a unit acoustic source configured to emit an acoustic wave through a volume of ground material. The controller is coupled to the acoustic transmitter and is configured to engage the unit acoustic source such that the acoustic wave fractures the volume of ground material at a target location.

Abstract: An electrosurgical system includes an electrosurgical power generating source, an energy-delivery device operably associated with the electrosurgical power generating source, and a processor unit. The electrosurgical system also includes an imaging system capable of generating image data including tissue temperature information. The processor unit is disposed in operative communication with the imaging system and adapted to analyze the image data to determine a specific absorption rate around the energy-delivery device as a function of the tissue temperature information obtained from the image data.

Abstract: Heat treatment is applied to tissue in need of such treatment which is surrounded by tissue not in need of such treatment, by positioning a deposit within the surrounding tissue adjacent the tissue in need of treatment. The dielectric constant and/or the conductivity of the deposit is greater than that of the surrounding tissue. A radio frequency antenna or antenna array directs a radio frequency signal at a selected frequency into the deposit. The deposit has a diameter within a range of about 0.5 times to about 0.16 times the wavelength of the radio frequency signal within the surrounding tissue. The deposit is heated, at least partially through resonant heating, to a temperature greater than the surrounding tissue to apply heat treatment to the tissue in need of treatment. The deposit may take the form of a balloon of a Mammosite® type device to provide hyperthermia treatment in conjunction with radiation treatment of a breast after a lumpectomy.

Abstract: A microwave delivery device, including a coaxial feedline having an inner conductor, an inner dielectric insulator coaxially disposed about, the inner conductor, and an outer conductor coaxially disposed about, the inner dielectric, and a radiating portion operably coupled to a distal end.

Abstract: A microwave ablation system includes an antenna assembly configured to deliver microwave energy from an energy source to tissue and a coolant source operably coupled to the energy source and configured to selectively provide fluid to the antenna assembly via a fluid path. The system also includes a controller operably coupled to the energy source and a piezoelectric transducer operably coupled to the fluid path to detect a force of fluid flow through the fluid path. The piezoelectric transducer is configured to generate a signal based on the detected force of fluid through the fluid path. The controller is configured to control the energy source output based on the generated signal.

Abstract: A surgical instrument includes a transducer configured to produce vibrations at a predetermined frequency. An ultrasonic blade extends along a longitudinal axis and is coupled to the transducer. A controller receives a feedback signal from the ultrasonic blade. A lumen is adapted to couple to a pump. The lumen conducts a fluid therethrough based on the feedback signal.

Abstract: A system for generating microwave energy includes a microwave generator that generates first and second microwave signals, a transmission line and a dual antenna microwave device. The transmission line transmits the first and second microwave signals to the microwave device. The microwave device includes a first antenna proximal a second antenna and a dual-sided choke positioned therebetween. The first antenna receives the first microwave signal from the transmission line between a first conductor and a second conductor and the second antenna receives the second microwave signal between the second conductor and a third conductor. The dual-sided choke includes a first and a second antenna choke circuit. The first antenna choke circuit limits the propagation of electromagnetic fields generated by the first antenna toward the second antenna and the second antenna choke circuit limits the propagation of electromagnetic fields generated by the second antenna toward the first antenna.

Abstract: Methods and apparatus are provided, for selective destruction or temporary disruption of nerves and/or conduction pathways in a mammalian body for the treatment of pain and other disorders. Apparatus comprises catheters having electrodes for targeting and affecting nerve tissue at a cellular level to reversible and irreversible nerve portion and incapacitation.

Abstract: Methods and systems for treating a tissue with a high frequency electric field to activate MAPK/ERK pathways, induce angiogenesis, induce angionenic factos such as NO and VEGF, or promote wound healing. Aspects of the invention are directed to methods of treating chronic wounds such as diabetic ulcers and hypoxia induced wounds. Aspects utilize high frequency electric field having a frequency in the GHz range, and preferably between about 1 GHz and about 10 GHz.

Abstract: An electrosurgical device for directing energy to a target volume of tissue includes a coaxial feedline having an inner conductor, an outer conductor and a dielectric material disposed therebetween. A proximal cylindrical dielectric sleeve is coupled to the inner conductor at a distal end of the coaxial feedline. A distal cylindrical dielectric sleeve is coupled to the inner conductor. First and second dielectric segments are coupled to the inner conductor and disposed between the proximal cylindrical dielectric sleeve and the distal cylindrical dielectric sleeve. The device also includes an elongated shaft overlying the proximal cylindrical dielectric sleeve, the first dielectric segment, the second dielectric segment and the distal cylindrical dielectric sleeve. The elongated shaft includes an opening defined therethrough, wherein the opening is at least partially aligned with the first dielectric segment.

Abstract: A microwave ablation probe for providing microwave energy to tissue is disclosed. The probe includes a feedline having an inner conductor, a secondary inner conductor, an insulating spacer, and an outer conductor. The inner conductor is slidably disposed within the secondary inner conductor. The feedline also includes a radiating portion having an extruded portion of the inner conductor centrally disposed therein, wherein longitudinal movement of the inner conductor relative to the feedline tunes the radiating portion.

Abstract: Methods and apparatus for irradiating biological tissue by EM radiation having radiation frequency(ies) of at most 10 Gigahertz are disclosed herein. In some embodiments, the tissue is irradiated by passing converging EM waves (e.g. generated using an ellipsoidal mirror 110) through a surrogate medium having a specially shaped ENTRY_SURFACE via which the converging EM waves enter the surrogate medium. In some embodiments, a refractive index at a sub-10 Gigahertz of the surrogate medium is at least 2 or at least 3 or at least 5 and/or substantially matches a refractive index of an irradiated biological tissue. In some embodiments, converging EM waves are formed within the surrogate medium. Some embodiments relate to methods and apparatus for irradiating neuron(s), for example, to non-invasively stimulating or otherwise modify a behavior of neuron(s) using focused or non-focused EM radiation.

Abstract: A catheter for magnetic resonance-supported interventional procedures has an electric cable that connects a first electric component attached to one catheter end with a second electric component attached to the other catheter end, with the electric cable being coiled at least in sections thereof.

Abstract: The invention relates to a system (1) for stimulating hair growth in a pre-determined area of skin, comprising: means (31) for generating high-voltage alternating current, means (35, 36) for generating a variable electric field from the high-voltage alternating current generated, and means (11) for applying the generated variable electric field to a pre-determined area of skin. In addition, the means for generating a variable electric field include at least two radiating elements (35, 36), while the means for generating high-voltage alternating current include a transformer (31), the primary of said transformer being disposed in relation to the core in such a way that, during operation, the radiating elements (35, 36) generate a variable electric field with a radiation pattern that concentrates its energy close to the means (11) for applying the variable electric field.

Abstract: A device and method is disclosed for preventing glaucomatous optic neuropathy, an affliction of the eye. An incision is made in the scleral region of the eye and an optic nerve head shield is inserted and positioned proximate to the optic nerve head of the eye to form a pressure seal over the optic nerve head of the eye. The optic nerve head shield decreases the pressure differential across the cribiform plate preventing bowing of the cribiform plate and glaucomatous optic neuropathy.

Abstract: A high-frequency treatment instrument of the present invention includes: a pair of forceps members that includes a conductive electrode portion and an insulating portion and is supported by the forceps rotation shaft so as to be relatively rotatable; an operation section configured to open and close the pair of forceps members; a link mechanism that is attached to the pair of forceps members and includes a pair of link members; an operation wire that connects the link mechanism to the operation section; a rotation contact member that is rotatably connected to the pair of forceps members; and a regulation wire in which one end thereof is electrically connected to the rotation contact member, a part of an intermediate portion thereof is disposed so as to pass through a space between the respective link members, and the other end thereof is electrically connected to a power supply.

Abstract: Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Improved results may be achieved by using a field with two or more frequencies.

Abstract: Methods and apparatus are provided for selective destruction or temporary disruption of nerves and/or conduction pathways in a mammalian body for the treatment of pain and other disorders. Apparatus comprises catheters having electrodes for targeting and affecting nerve tissue at a cellular level to reversible and irreversible nerve poration and incapacitation.

Abstract: A microwave ablation system is provided. The microwave ablation system includes a power source. A microwave antenna is adapted to connect to the power source via a coaxial cable feed including an inner conductor defining a portion of a radiating section of the microwave antenna, an outer conductor and dielectric shielding. The inner conductor loops back around and toward the outer conductor of the coaxial cable feed such that a distal end of the inner conductor is operably disposed adjacent the dielectric shielding. The inner conductor includes one or more reactive components disposed thereon forming a reactively-loaded loop configuration configured to maximize delivery of microwave energy from the power source to tissue such that a desired effect to tissue is achieved.

Abstract: An electrosurgical device for directing energy to tissue includes a coaxial feedline having an inner conductor, an outer conductor coaxially disposed around the inner conductor, and a dielectric material disposed therebetween. An elongated electrically-conductive member is longitudinally disposed at a distal end of the inner conductor; a balun structure is disposed on the outer conductor. An electrically-conductive cylinder is coaxially disposed around a distal portion of the balun structure and a dielectric structure is disposed substantially adjacent to a distal end of the electrically-conductive cylinder and configured to extend to a distal end of the electrically-conductive member. An elongated handle assembly is coaxially disposed around a portion of the outer conductor proximal to the dielectric structure and a shell assembly is disposed at a distal end of the elongated handle assembly.

Abstract: Methods and apparatus are provided for selective destruction or temporary disruption of nerves and/or conduction pathways in a mammalian body for the treatment of pain and other disorders. Apparatus comprises catheters having electrodes for targeting and affecting nerve tissue at a cellular level to reversible and irreversible nerve poration and incapacitation.

Abstract: An integrated system and method for treatment of various diseases, including psychiatric, mental and brain disorders, which preferably combines personalized non-invasive neuronal brain stimulation together with appropriate personalized cognitive training, and which iteratively fine-tunes this treatment by monitoring specific cognitive and brain functions in response to the treatment. A novel brain stimulator device and method, Computerized Magnetic Photo-Electric Stimulator (CCMPES), is described, which integrates electromagnetic stimulation with laser stimulation to generate a magnetic photo-electric stimulation.

Abstract: A method of transdermal drug delivery using drug formulations and other small molecules is described. The drug or other small molecule formulation is applied to the skin of a patient using a radio frequency device. The radio frequency device facilitates the ablation of the stratum corneum allowing the drug or other small molecule to pass to the underlying skin. The drug or small molecule can be contained in hyaluronic acid nanoparticles or suspended in a gel.

Abstract: An electrical lead for implantation into an animal includes a cable to which a stimulation electrode is connected. The cable has a helical electrical conductor enclosed within an insulating sheath. The stimulation electrode has a tubular first contact band with a threaded lumen into which a portion of the helical electrical conductor is screwed. A second contact band has a threaded aperture and a helical electrode coil is screwed into both the threaded lumen and the threaded aperture. The two contact bands are separated so as to expose a portion of the electrode coil to enable electrical stimulation of tissue of the animal. Particular configurations of the helical electrode coil and the helical electrical conductor render the electrical lead compatible with MRI scanning.

Abstract: The invention concerns a flexible application device (1) for the high-frequency therapy of biological tissue or hollow organs, including a tubular high-frequency catheter (5) with a flexible shaft tube (6) having at least one lumen passing therethrough, a head electrode (2) arranged at the distal end of the high-frequency catheter (5), an electric line (9) with a connection (20) for a high-frequency generator (11), and a connecting element (8) arranged at the proximal end of the shaft tube (6) between the shaft tube and the line (9).

Abstract: An electrosurgical device for directing energy to a target volume of tissue includes a coaxial feedline having an inner conductor, an outer conductor coaxially disposed around the inner conductor, and a dielectric material disposed therebetween. An elongated electrically-conductive member is longitudinally disposed at a distal end of the inner conductor. A balun structure is disposed on the outer conductor. The device also includes an electrically-conductive cylinder coaxially disposed around a distal portion of the balun structure, and a dielectric structure disposed substantially adjacent to a distal end of the electrically-conductive cylinder, wherein the dielectric structure longitudinally extends from the distal end of the electrically-conductive cylinder to a distal end of the electrically-conductive member.

Abstract: An electrosurgical device for directing energy to a target volume of tissue includes a coaxial feedline having an inner conductor, an outer conductor and a dielectric material disposed therebetween. A proximal cylindrical dielectric sleeve is coupled to the inner conductor at a distal end of the coaxial feedline. A distal cylindrical dielectric sleeve is coupled to the inner conductor. First and second dielectric segments are coupled to the inner conductor and disposed between the proximal cylindrical dielectric sleeve and the distal cylindrical dielectric sleeve. The device also includes an elongated shaft overlying the proximal cylindrical dielectric sleeve, the first dielectric segment, the second dielectric segment and the distal cylindrical dielectric sleeve. The elongated shaft includes an opening defined therethrough, wherein the opening is at least partially aligned with the first dielectric segment.

Abstract: An electrosurgical device for directing energy to a target volume of tissue includes a coaxial feedline having an inner conductor, an outer conductor coaxially disposed around the inner conductor, and a dielectric material disposed therebetween. An elongated electrically-conductive member is longitudinally disposed at a distal end of the inner conductor; a balun structure is disposed on the outer conductor. An electrically-conductive cylinder is coaxially disposed around a distal portion of the balun structure and a dielectric structure is disposed substantially adjacent to a distal end of the electrically-conductive cylinder and configured to extend to a distal end of the electrically-conductive member. An elongated handle assembly is coaxially disposed around a portion of the outer conductor proximal to the dielectric structure and a shell assembly is disposed at a distal end of the elongated handle assembly.

Abstract: An ingestible capsule is provided for delivering medication to a subject. A capsule coating dissolves in a gastrointestinal tract of the subject. An inner core of the capsule has an outer surface associated therewith. The outer surface is disposed within the coating and expands when the coating dissolves. A medication is disposed on the outer surface, and the outer surface is configured such that the medication contacts an intestinal wall of the subject when the outer surface expands. Other embodiments are also provided.

Abstract: A microwave ablation probe for providing microwave energy to tissue is disclosed. The probe includes a feedline having an inner conductor, a secondary inner conductor, an insulating spacer, and an outer conductor. The inner conductor is slidably disposed within the secondary inner conductor. The feedline also includes a radiating portion having an extruded portion of the inner conductor centrally disposed therein, wherein longitudinal movement of the inner conductor relative to the feedline tunes the radiating portion.

Abstract: Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Improved results may be achieved by using a field with two or more frequencies.

Abstract: A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43° C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

Abstract: A high-frequency treatment instrument of the present invention includes: a pair of forceps members that includes a conductive electrode portion and an insulating portion and is supported by the forceps rotation shaft so as to be relatively rotatable; an operation section configured to open and close the pair of forceps members; a link mechanism that is attached to the pair of forceps members and includes a pair of link members; an operation wire that connects the link mechanism to the operation section; a rotation contact member that is rotatably connected to the pair of forceps members; and a regulation wire in which one end thereof is electrically connected to the rotation contact member, a part of an intermediate portion thereof is disposed so as to pass through a space between the respective link members, and the other end thereof is electrically connected to a power supply.

Abstract: As compared to conventional electrodes, the electrode configurations disclosed herein minimize irritation and damage to the skin when they are placed in contact with a patient's body over extended of time. The electrodes are formed from a conductive substrate coated with a thin dielectric material, and a plurality of open spaces pass through the electrodes. Those open spaces are distributed and sized to permit moisture on the surface of the patient's body to escape when the electrode is placed in contact with the patient's body. One intended use for the electrodes is for treating tumors by applying an AC electric field with specific frequency and field strength characteristics over an extended period of time.

Abstract: The invention provides a microwave heating method and apparatus for evenly heating an object, such as a person's body. The methods and apparatus involve use of microwave source (or sources) that outputs multiple microwaves that are non-correlated with each other in phase; an array of antennas that radiate substantially plane microwaves to form a pseudo uniform microwave electromagnetic field, where the microwaves are not phase-correlated, in order to eliminate non-uniform heating caused by interference. Each of the antenna array consists of multiple antenna units, each antenna unit consists of at least one microwave radiator and at least one converter that converts the spherical microwave to plane microwave. A computer based control system and a temperature monitoring subsystem can be used to adjust the output of each antenna, in order to enhance the uniform heating effect. The apparatus and method can be used to perform whole-body hyperthermia or regional hyperthermia.

Abstract: Method and apparatus for cellular and intracellular manipulation of cell functions with ultrashort electrical pulses and for targeted delivery of the electrical pulses into cell cultures, patients, and tissues.

Abstract: An apparatus and method for the treatment of chronic wounds using electromagnetic energy. The apparatus includes a generator and at least one applicator. The generator can produce electromagnetic energy and the applicator can apply the electromagnetic energy produced by the generator. A detector is disposed on the applicator that can measure the field strength of the electromagnetic energy applied.

Abstract: Medical catheter apparatus for minimally invasive applications includes a probe for radiating electromagnetic waves of a first frequency capable of heating tissue and detecting thermal emissions from that tissue of a second frequency indicative of tissue temperature. The probe has an inner conductor extending along the probe to a conductive probe tip and a concentric tubular outer conductor having a leading end spaced rearwardly from the probe tip and a closed trailing end shorted to the inner conductor. A dielectric sheath surrounds the outer conductor which sheath has a leading end spaced rearwardly from the leading end of the outer conductor. A diplexer integrated into the probe includes a filter circuit positioned inside the outer conductor and a coupling capacitor connected between a point on the inner conductor and the input of the filter circuit such that the conductors between that point and the shorted trailing end of the outer conductor constitute a quarter wave stub at the second frequency.

Abstract: Using pulsed or continuous-wave sources, broadband electromagnetic energy generally in the 10 MHz to 300 GHz range is applied through one or a plurality of near-field antennas such as coaxial probe tips. The electromagnetic energy reflected from the surface or transmitted through the near surface of the object (e.g. surface of skin or other tissue or cells) is detected, and the ratio of the test measurement to that from normal tissue is recorded and presented to determine the degree of dielectric contrast, hence inhomogeneity. This degree of contrast is used both on its own and in conjunction with simultaneously acquired optical images to map the boundary of an organ inhomogeneity such as a tumor. The bundle of antennas may be scanned over a surface of the object on a pixel-by-pixel basis to determine the spectra of the sample on a pixel-by-pixel basis, allowing a two dimensional display of the absorption spectra to be provided.

Abstract: An interverterbral fissure can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element. The next step is applying a force longitudinally to the proximal of the catheter which is sufficient to advance the intradiscal section through the nucleus pulposus and around an inner wall of an annulus fibrosus, but which force is insufficient to puncture the annulus fibrosus. Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. Then the functional unit treats the annular fissure. Optionally, there is an additional step of adding a substance to seal the fissure.

Abstract: A radio-frequency based catheter system and method for ablating biological tissues within the body vessel of a patient comprises a radio-frequency (“RF”) generator for selectively generating a high frequency RF energy signal in a deployable catheter having an RF transmission line, an RF antenna mounted on the distal portion of the catheter, and a temperature sensor also mounted on a distal portion of the catheter for detecting temperature adjacent an ablation site. A control system adjusts the RF energy signal so that the detected temperature is at or close to a selected temperature setting or within a selected temperature range.

Abstract: There are disclosed methods of vein closure. In an embodiment, a method includes elevating a leg of a patient during a vein closure procedure so as to effect substantial emptying of the vein. The method also includes applying radio-frequency energy to a vein within the leg of the patient to cause the vein closure. In another embodiment, a method includes elevating a leg of a patient during a vein closure procedure within a range of about 30 degrees to about 45 degrees from a horizontal position. The method also includes applying radio-frequency energy to a vein within the leg of the patient. In one embodiment, a method includes elevating a leg, and emptying of a segment of the vein prior to applying radio-frequency energy. In another embodiment, the method includes elevating a leg of a patient, and applying energy to a vein. Other embodiments are also disclosed.