Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of growth differentiation factor 10 (“GDF10”), a useful protein, by tissues. Also described are methods of enhancing expression of GDF10 in cells, particularly a method of stimulating the expression and/or release of GDF10 in a cell having a gene encoding GDF10, wherein the method includes applying a bioelectric signal produces, as measured at the level of the target cells or tissues being stimulated 2 mA to 4 mA direct current positive to the cell (e.g., directly, indirectly, or wirelessly). Applications in the treatment of cerebral strokes, brain injuries, paralysis, brain cancer, Alzheimer's disease, dementia, anxiety, Parkinson's disease, and/or essential tremors are also disclosed.

Abstract: An electrical stimulation-based ankle muscle rehabilitation training apparatus comprising: an ankle movement providing device that provides dorsiflexion, plantarflexion, eversion, inversion, supination, and pronation operations; first and second electrode pads respectively attached to the proximal and distal portions of the tibialis anterior representative of the ankle dorsiflexor; third and fourth electrode pads respectively attached to the proximal and distal portions of the peroneus longus representative of the ankle evertor; an electrical stimulation providing unit for applying electrical stimulation to the first to fourth electrode pads; and a control unit that controls the ankle movement providing device to sequentially perform a first operation of repeating dorsiflexion and plantarflexion movements, a second operation of repeating eversion and inversion movements, and a third operation of repeating supination and pronation movements at an appropriate slow speed, and controls the electrical stimulation

Abstract: A device for stimulating left and right eyelid closure of a patient. A first pair of electrodes is configured to be attached in spaced apart relation to one another proximate to a left facial nerve of the patient for activating closure of the left eyelid. A second pair of electrodes is configured to be attached in spaced apart relation to one another proximate to a right facial nerve of the patient for activating closure of the right eyelid. A controller in communication with the first and second pairs of electrodes is configured to provide electrical signals to the first and second pairs of electrodes for stimulating closure of the left and right eyelids. A power supply in communication with the controller is configured to supply electrical power to the controller and the first and second pairs of electrodes.

Abstract: The invention relates to a system for body-condition-dependent stimulation by means of function modules, e.g. an action module (2, D/A module) for stimulating tissue and a capture module (3, A/D module) for deriving/measuring bio data or bio signals, characterized in that the two modules communicate via a communication link (5) that meets hard or at least firm real-time requirements. The communication link (5) preferably comprises a real-time-capable bus to which the two modules are connected, above all an EtherCAT bus.

Abstract: Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes. The medical system determines a first change of a first sensed signal of the patient to movement by the patient and a second change of a second sensed signal of the patient to the movement by the patient. Based on the first change and the second change, the medical system selects one of the first sensed signal and the second sensed signal of the patient for controlling the electrical stimulation therapy. The medical system adjusts a level of at least one parameter of the electrical stimulation therapy based on the selected one of the first sensed signal and the second sensed signal.

Abstract: Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes. Further, the method includes adjusting a level of a parameter of the electrical stimulation therapy such that a signal of the patient is not less than a lower bound and not greater than an upper bound. The lower bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce one or more symptoms of a disease while the patient was receiving medication for reduction of the one or more symptoms. Further, the upper bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce the one or more symptoms when the patient was not receiving the medication.

Abstract: A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation and pulsating heat. Also described is a device for treating tumors at a target site. The device includes a first balloon containing a radio isotope and a second balloon encasing the first balloon. The second balloon defines structures to create a void between the first balloon and the second balloon such that pulsing, temperature treated fluid traverses the void.

Abstract: Methods and systems for providing stimulation to a patient's brain using one or more electrode leads implanted in the patient's brain are described. The methods and systems use evoked potentials (EPs) and other indicators of therapeutic effectiveness/side effects to provide closed-loop control of the stimulation. Some embodiments involve recording EPs and using one or more features of the EPs to model how the stimulation activates networks within the patient's brain. A control algorithm can be used to maintain the network activation within a predetermined ranges.

Abstract: A pulsed electromagnetic field (PEMF) device includes at least one electromagnetic (EM) field emitter. During post-birth recovery, a patient applies the EM field emitter to herself. The PEMF device performs a recovery cycle. In the recovery cycle, the EM field emitter emits EM fields having frequency combinations with a response frequency and a target frequency for a frequency combination period.

Abstract: Systems and methods for identifying a condition associated with an individual in a home environment are provided. Sensors associated with the home environment detect data, which is captured and analyzed by a local or remote processor to identify the condition. In some instances, the sensors are configured to capture data indicative of electricity use by devices associated with the home environment, including, e.g., which devices are using electricity, what date/time electricity is used by each device, how long each device uses electricity, and/or the power source for the electricity used by each device. The processor analyzes the captured data to identify any abnormalities or anomalies, and, based upon any identified abnormalities or anomalies, the processor determines a condition (e.g., a medical condition) associated with an individual in the home environment. The processor generates and transmits a notification indicating the condition associated with the individual to a caregiver of the individual.

Abstract: Provided are systems, methods, and devices for measurement, identification, and generation of sleep state models. Systems include a plurality of electrodes configured to be coupled to a brain of a user and configured to obtain a plurality of measurements from the brain of the user, and an interface configured to obtain the plurality of measurements from the plurality of electrodes. Systems include a processing device comprising one or more processors configured to generate a sleep state model associated with the user, the sleep state model identifying characteristics of a plurality of sleep stages, and further identifying characteristics of transitions between the plurality of sleep stages. Systems include a controller comprising one or more processors configured to generate a control signal based on the sleep state model and the plurality of measurements.

Abstract: An implantable device for delivery of a macromolecular drug compound is provided. The device comprises a core having an outer surface and a membrane layer positioned adjacent to the outer surface of the core. The core comprises a core polymer matrix within which is dispersed a drug compound having a molecular weight of about 0.5 kDa or more, the polymer matrix containing a hydrophobic polymer. Further, the membrane layer comprises a plurality of water-soluble particles distributed within a membrane polymer matrix containing an ethylene vinyl acetate copolymer, wherein the water-soluble particles have a D50 particle size of about 150 micrometers or less and contain a non-polymeric, hydroxy-functional compound.

Abstract: Systems and methods for treating cancerous tumors (including glioblastoma multiforme (GBM)) with electrotherapy, such as deep brain stimulation (DBS) technology, as disclosed herein. One or more configurations can be generated based on a patients tumor characteristics. The selected configurations can be electrode configurations or settings for an electrical source coupled to the electrodes. The one or more configurations can be targeted for inhibiting cell growth process, such as to inhibit mitosis, immune suppression, or to inhibit DNA replication. Inhibition of cell growth processes can initiate death of the cancerous cells.

Abstract: The present disclosure describes an endotracheal ventilator tube for the treatment of dysphagia comprising an elongate tube and at least one electrode positioned on or about the elongate tube, wherein the at least one electrode is configured to deliver electrical stimulation to the oropharyngeal region and is electrically connected to an electrical stimulation generating means.

Abstract: An apparatus includes an implantable stimulator to treat sleep disordered breathing (SDB) and at least one electrode associated with the stimulator. The apparatus may include a microstimulator including a housing to encapsulate at least stimulation circuitry and a control portion including a therapy manager to control the stimulation circuitry based on at least control information.

Abstract: The systems and methods described herein generally relate to adjusting a neurostimulation (NS) therapy based on drug pharmacokinetics of a patient. The systems and methods deliver an NS therapy to a portion of electrodes of a lead positioned proximate to neural tissue of interest, which is associated with a target region. The NS therapy is defined by stimulation parameters. The systems and methods determine a trigger event indicative of a drug being administered to a patient. The drug is configured to affect at least one of the neural tissue of interest or the target region. The systems and methods adjust one or more of the stimulation parameters based on the PS profile.

Abstract: The present invention relates to a system and method, in which a distal end of an electrode is implanted in an organ, such as a pituitary gland, for intermittent electrical stimulation thereof and a proximal end of the electrode is provided with a connection plug, a distal end of which can be attached to a bone adjacent the organ, such an anterior wall of the sphenoid sinus/vomer, and a proximal end of which can be reversibly connected electrically to a wire that is connected electrically to a source of electrical stimulation for the organ.

Abstract: In an embodiment, the present disclosure pertains to an organ-specific wireless optogenetic device. In some embodiments, the device includes an electronic circuit, such that the electronic circuit is configured to harvest and convert radio frequency (RF) energy into optical energy and a tether having a ?LED, where the ?LED illuminates targeted regions in the organ. In an additional embodiment, the present disclosure pertains to a method of treating obesity. In general, the method includes implanting an organ-specific wireless optogenetic device into a subject, activating an RF-power system to produce RF energy, harvesting, by the organ-specific wireless optogenetic device, the RF energy, converting, by the organ-specific wireless optogenetic device, the RF energy into optical energy, illuminating, by the ?LED, targeted regions in the stomach of the subject, and stimulating nerve endings to thereby suppress appetite in the subject.

Abstract: Wearable fetal health monitoring device for determining a heath condition of a fetus based on biosignals of an expecting mother and the fetus is provided. The device includes a MEMS accelerometer that converts an acoustic wave sensed in an abdominal region into an abdominal acoustic signal. The device also includes a pulse oximeter generates a maternal photoplethysmogram (mPPG) value from a pulse sensed in the abdominal region. The device further includes a microcontroller configured to: generate a maternal phonocardiogram (mPCG) value from the abdominal acoustic signal; calculate a first maternal heart rate (mHR) value from the mPCG value; calculate a second mHR value from the mPPG value; compare the first mHR value with the second mHR value to identify a noise correction value; and apply the identified noise correction value to the mPCG value to extract a fetal phonocardiogram (fPCG) value.

Abstract: Provided is a catheter including a shaft having a distal end removably connected to a distal portion and a proximal end coupled to a holder; a loop disposed near the distal end and configured to curl around a tissue and receive, via the shaft, energy to denervate at least a portion of the tissue; a loop control disposed on a butt of the holder and configured to deliver a mechanical bending force to the loop. The loop includes at least a portion made of a shape-memory alloy whose shape changes at a critical temperature. In a first mode, the loop is configured to curl around the tissue at a first curvature at a temperature below the critical temperature by the mechanical bending force. In a second mode, the loop is configured to curl around the tissue at a second curvature at a temperature above the critical temperature.

Abstract: Disclosed herein are systems and methods for electrically modulating tissue. Systems can include a current generator; at least one implantable working electrode, the at least one implantable working electrode configured to be in electrical communication with the current generator; at least one indifferent electrode; and a controller configured to signal the current generator to: generate a set of currents with a set of initial polarities to be delivered to the working electrodes; and wherein the at least one indifferent electrode absorbs a bias current which is equal in magnitude and opposite in polarity to a summation of the set of currents.

Abstract: Disclosed is an apparatus for controlling the output of a skin care device, which can reduce a peak power to be output to the skin, by suppressing a sudden current change when a direct current voltage is converted into an alternating current voltage. The disclosed apparatus for controlling the output of a skin care device: amplifies a direct current voltage and outputs same; converts the output direct current voltage into an alternating current voltage with a set frequency and outputs same to a pair of contact electrodes; and detects the skin current according to changes in the resistance of the skin to which the alternating current voltage is applied, so as to control the amplification of the direct current voltage.

Abstract: Systems and methods provide stimulation of peripheral targets such as targets in the lower limbs. Electrode arrays realized in circumferential or longitudinal embodiments have pads with horizontal and/or vertical offsets. Electrode array geometries are customizable and adaptable to individual users and treatment of different disorders. Novel systems of customization include software and hardware implemented solutions. A single device can provide treatment of two or more disorders or unwanted states using selected electrode geometries and stimulation protocols. Systems and methods for assessment of candidate stimulation sites and protocols use subjective or objective measures or both to determine which meet stimulation success criteria. Simulation is provided using transcutaneous, percutaneous, or implantable stimulators. A main advantage is the improved treatment of pelvic floor disorders, and especially overactive bladder (OAB).

Abstract: A tubing assembly for use with an electronic catheter guidance systems is provided and includes a catheter and a stimulation electrode assembly, and an electrical connection for delivering a stimulation waveform to the stimulation electrode assembly. The catheter extends in a longitudinal direction and has a proximal end and a distal end that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract. The stimulation electrode assembly is configured to deliver an electrical stimulation to tissue. A catheter guidance system and method for accurately placing a catheter in the digestive tract are also provided.

Abstract: A method for predicting heart rate (HR) of a user during a physical activity, comprising: monitoring the user during the physical activity with an wearable electronic device comprising a photoplethysmography (PPG) sensor, an accelerometer, a memory and a processor; wherein the memory is configured to store user demographic data, PPG data and accelerometer data detected by the PPG sensor and the accelerometer, respectively. The method includes computing a PPG heart rate estimation and a PPG quality flag using the PPG data and accelerometer data, wherein the PPG quality flag indicates whether the PPG data is reliable or not; computing an exponential heart rate estimation by applying the PPG heart rate estimation, the PPG quality flag and the user's demographic data on an exponential approximation model; if the PPG quality flag is reliable, outputting the PPG heart rate estimation; otherwise, outputting the exponential heart rate estimation.

Abstract: The present invention provides a portable guidance device for cardiopulmonary resuscitation, which comprises a tri-axial gravity sensing element, a pressure sensing element, a sound output element, a visual output element and a microcontroller. The portable guidance device for cardiopulmonary resuscitation can actively connect to the medical rescue system and issue an alarm to guide the surrounding passers-by to perform real-time rescue and perform correct cardiopulmonary resuscitation, so as to improve the efficiency and accuracy of chest compressions.

Abstract: The present disclosure provides a handpiece capable of adjusting the depth of focus, including a case, a cartridge installed to be movable in a vertical direction inside the case and having a transducer that emits ultrasonic waves, and a vertical movement unit mounted inside the case and moving the transducer in a vertical direction by a magnetic force.

Abstract: A system includes a first bus, a second bus, a first battery that includes a first plurality of cells, and a second battery that includes a second plurality of cells, wherein the second battery is connected to the second bus. A first converter connects the first battery to the first bus. A second converter connects the first bus to the second bus. A controller is configured to control operation of the first converter and the second converter.

Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.

Abstract: According to some embodiments, a system and method for treating meibomian gland dysfunction is disclosed. The system comprises one or more electrode pads configured for placement on a patient's face on either a lower eyelid, an upper eyelid or both the lower and upper eyelids, a processor and a non-transitory, computer-readable medium. The computer-readable medium stores program code. The program code is executable by a processor to cause the processor to transmit an instruction to the controller to initiate a biofeedback indicator wherein the biofeedback does not cause muscle contraction.

Abstract: A heater control system for a gas delivery system of a substrate processing system includes an oven, N resistive uninsulated heaters arranged inside of the oven, where N is an integer greater than one, and a controller. The oven encloses one or more components of the substrate processing system and to maintain a predetermined temperature in the oven. Each of the N resistive heaters selectively heats at least a portion of one of the components in the oven. The controller is configured to maintain the predetermined temperature in localized regions in the oven by determining a resistance in each of the N resistive heaters and adjusting power to each of the N resistive heaters based on N-1 resistance ratios of N-1 of the N resistive heaters relative to one of the N resistive heaters.

Abstract: A closed-loop spinal cord electrical stimulation system includes a spinal epidural electrical stimulation electrode, a low limb electrical stimulation electrode, a closed-loop electrical stimulator and a controller. The spinal epidural electrical stimulation electrode, the low limb electrical stimulation electrode and the controller are electrically connected to the closed-loop electrical stimulator respectively. The spinal epidural electrical stimulation electrode is used for applying a first electrical stimulation to the spinal epidural site, and the low limb electrical stimulation electrode is used for applying a second electrical stimulation to a low limb. The voltage of the first electric stimulation is 400-600 mV, the voltage of the second electric stimulation is 1 V-1.5 V, and the stimulation frequency of the both is 10-20 Hz.

Abstract: A wearable cardioverter defibrillator (WCD) system includes a processor, a memory, a wireless communication module (DWCM), and an NFC tag that stores information for how an accessing device may access the DWCM wirelessly. An accessing device such as a defibrillator configurator with an NFC reader may read the NFC tag of the WCD system, if it has adequate permission to do so. Upon so reading, the accessing device will know how to address the DWCM wirelessly, and thus install or update configuration data, software updates, or request memory downloads from operations. The use of the NFC tag requires close proximity, which hampers both inadvertently programming the wrong WCD system, plus a WCD system being attacked maliciously.

Abstract: Embodiments may provide a general-purpose, relatively inexpensive, AI-driven implant that is able to adapt to and modulate any given neuron, circuit, or region in the brain, as well as individual cells of any type of tissue. For example, in an embodiment, a method for interacting with living tissue may comprise attaching a device to a body of a person or animal, the device comprising plurality of carbon fibers in contact with the living tissue, receiving by the carbon fibers signals from the living tissue, processing the received signals by the device, and transmitting the processed signals.

Abstract: The disclosed electrical stimulation system generates interventions to assist patients in complying with a diet. The wearable device includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a T2 dermatome to a T12 dermatome or meridian of the patient, a C5 to a T1 dermatome across the hand and/or arm, and/or the upper chest regions. The device is adapted to provide electrical stimulation as per stimulation protocols and to communicate wirelessly with a companion control device configured to monitor and record appetite patterns of the patient and deliver titrated therapy. The control device is also configured to monitor, record, and modify stimulation parameters of the stimulation protocols.

Abstract: An epicardial pacer wire management device can include a spool defining a recessed region that encompasses the spool. The recessed region can receive a portion of a pacer wire. The device can further include a connector attached to the spool, and the connector can be electrically coupled with an exposed tip of the pacer wire. The device can further include an electrical port attached to the spool that can communicate with a pacing control unit. The device may include an electrical communication line electrically coupled between the connector and the electrical port.

Abstract: Systems for destroying or inhibiting cancer cells and other rapidly-dividing cells including an alternating polarity (AP) magnetic field generator and at least one AP electromagnetic coil adapted to be coupled to a target body area, and a controller to control the AP magnetic field generator and at least one AP electromagnetic coil and cause the field generator and coil to apply AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.

Abstract: An exemplary diagnostic system may be configured to direct an acoustic stimulation generator to apply acoustic stimulation to a recipient of a cochlear implant during an insertion procedure in which an electrode lead coupled to the cochlear implant is supposed to be inserted into a cochlea of the recipient, direct the cochlear implant to use an electrode on the electrode lead to record an evoked response signal that occurs within the recipient in response to the acoustic stimulation, detect an anomaly in the evoked response signal, and determine, based on the anomaly, that the electrode lead is being inserted into a vestibular canal instead of into the cochlea.

Abstract: Treatment controllers and methods are provided that can be integrated with treatment systems, such as peritoneal dialysis systems, hemodialysis systems, and nocturnal treatment systems, to manage execution of treatment operations or a course of treatment based on timing information and/or patient sleep state.

Abstract: A implantable neural electrode assembly is described. The implantable neural electrode assembly includes a plurality of open-ended rings alternatingly connected to a spine. An inner layer of the open-ended rings is formed from a drug-loaded material (e.g., silicone that has been loaded with a steroid) and an outer layer is formed from a drug-free material. One or more electrode assemblies are connected to the inner layer and oriented towards a center of a cylinder defined by the plurality of open-ended rings.

Abstract: A method for gait retraining of a runner includes: measuring acceleration data of at least one lower leg of the runner; diagnosing the acceleration data thereby determining a measure of the impact intensity of at least one external tibial shock; and providing real-time feedback to the runner by converting the measure of the impact intensity into distortion of music to a level which is perceived by the runner as a measure for the impact intensity. The conversion is done based on a predefined relationship between perceived distortion levels and imposed distortion levels, and the runner can reduce the distortion of the music by adjusting his or her gait.

Abstract: Methods for treating post-traumatic stress disorder (PTSD) and/or for reducing a risk associated with developing PTSD in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with PTSD as well as an increased risk of developing PTSD following a traumatic event. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to a PTSD status in the patient. Other aspects are directed to reducing a likelihood of developing PTSD in patients presenting one or more PTSD risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's PTSD status or risk of developing PTSD. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g.

Abstract: The invention discloses an electrochemical device for treating cancer, characterized by using an acupuncture needle as a working electrode to produce hydrogen in a tumor tissue, thereby destroying the tumor tissue through the produced hydrogen gas. The device of the invention has low cost and simple operation, can realize minimally invasive treatment, and is green and environmentally friendly.

Abstract: A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.

Abstract: Contraction stimulation therapy can treat myriad diseases, including lymphedema using a skin patch or implantable stimulator that includes a multiplicity of electrodes, a processor, a stimulation circuit, one or more sensors and programming for a patient interface unit, wherein the processor is programmed to control selection of a subset of the multiplicity of electrodes and of operation of the stimulation circuit responsive to an indication of an adverse physiologic response. The indication of patient discomfort may be determined by monitoring a physiologic parameter of the subject using the one or more sensors, by direct input from the subject via the patient interface unit programming, or a combination thereof. The devices, systems and methods also provide for automatically optimizing the stimulation parameters applied by the stimulation circuit responsive to feedback from the one or more sensors and/or by using direct input from the subject.

Abstract: A pharmaceutical composition suitable for preventing or treating cardiac arrhythmia is disclosed. The pharmaceutical composition contains, as an active ingredient, a CCN5 protein or a nucleotide encoding the CCN5 protein. The pharmaceutical composition inhibits the pathological activity of CaMKII, which induces cardiac electrical abnormalities that is the main cause of atrial arrhythmia and ventricular arrhythmia, so as to restore the electrical functions, and inhibits the activity of myofibroblasts causing structural abnormalities. Therefore, the pharmaceutical composition can be effectively used in the prevention or treatment of cardiac arrhythmia.

Abstract: An electrosurgical generator capable of supplying energy in a waveform that causes electroporation in biological tissue. The electrosurgical generator may comprise an electroporation waveform supply unit that is integrated with an electromagnetic signal supply unit for generating microwave electromagnetic signals and radiofrequency electromagnetic signals for treatment. The electrosurgical generator may be configured to deliver different types of energy along a common feed cable. The electroporation waveform supply unit comprises a DC power supply and a DC pulse generator. The DC power supply may include a DC-DC converter for up-converting a voltage output by an adjustable voltage supply. Each DC pulse may have a duration in the range 1 ns to 10 ms and a maximum amplitude in the range 10 V to 10 kV.

Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.

Abstract: An intelligent bioelectric module for use with a drug delivery system has a case and a set of at least two electrodes in electrical communication with a detection surface of the case. The case is configured so that, in use, the detection surface comes into electrical communication with (i) a second surface of the delivery system when a first surface of the delivery system has been put into contact with a tissue surface of a human or animal subject or (ii) the tissue surface that is adjacent to a portion contacted by the first surface of the delivery system or (iii) both the second surface and the tissue surface.

Abstract: An Example of a system for providing a patient with pain management may include a sleep monitoring circuit, a pain relief device, and a control circuit. The sleep monitoring circuit may be configured to sense one or more sleep signals from the patient and to determine a sleep state of the patient using the one or more sleep signals. The one or more sleep signals may include one or more physiological signals corresponding to the sleep state of the patient. The pain relief device may be configured to deliver one or more pain relief therapies. The control circuit may be configured to control the delivery of the one or more pain relief therapies using therapy parameters and to adjust the therapy parameters based on the determined sleep state.