Combined With Nonelectrical Therapy Patents (Class 607/3)
  • Patent number: 12155251
    Abstract: A system includes a first bus, a second bus, a first battery that includes a first plurality of cells, and a second battery that includes a second plurality of cells, wherein the second battery is connected to the second bus. A first converter connects the first battery to the first bus. A second converter connects the first bus to the second bus. A controller is configured to control operation of the first converter and the second converter.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: November 26, 2024
    Assignee: APPLE INC.
    Inventors: Philip W. Juang, Christopher D. Laws, Brandon Pierquet, Giridhar N. Murching, William A. Braff
  • Patent number: 12151126
    Abstract: The present disclosure provides a handpiece capable of adjusting the depth of focus, including a case, a cartridge installed to be movable in a vertical direction inside the case and having a transducer that emits ultrasonic waves, and a vertical movement unit mounted inside the case and moving the transducer in a vertical direction by a magnetic force.
    Type: Grant
    Filed: November 16, 2023
    Date of Patent: November 26, 2024
    Assignee: SHENB Co., Ltd.
    Inventor: Sun Young Kang
  • Patent number: 12109415
    Abstract: According to some embodiments, a system and method for treating meibomian gland dysfunction is disclosed. The system comprises one or more electrode pads configured for placement on a patient's face on either a lower eyelid, an upper eyelid or both the lower and upper eyelids, a processor and a non-transitory, computer-readable medium. The computer-readable medium stores program code. The program code is executable by a processor to cause the processor to transmit an instruction to the controller to initiate a biofeedback indicator wherein the biofeedback does not cause muscle contraction.
    Type: Grant
    Filed: November 29, 2023
    Date of Patent: October 8, 2024
    Inventor: Eric Rubinfeld
  • Patent number: 12109411
    Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: October 8, 2024
    Assignee: GRAND DECADE DEVELOPMENTS LIMITED
    Inventors: John Rodriguez, Jason Jin, Brandon Dang Phung, Wesley Joel Ericson, Jodie Marie Houdek, Jonathan Joseph McIntosh, Carlos E. Gonzalez, Anthony Steven Nault
  • Patent number: 12062554
    Abstract: A heater control system for a gas delivery system of a substrate processing system includes an oven, N resistive uninsulated heaters arranged inside of the oven, where N is an integer greater than one, and a controller. The oven encloses one or more components of the substrate processing system and to maintain a predetermined temperature in the oven. Each of the N resistive heaters selectively heats at least a portion of one of the components in the oven. The controller is configured to maintain the predetermined temperature in localized regions in the oven by determining a resistance in each of the N resistive heaters and adjusting power to each of the N resistive heaters based on N-1 resistance ratios of N-1 of the N resistive heaters relative to one of the N resistive heaters.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: August 13, 2024
    Assignee: LAM RESEARCH CORPORATION
    Inventors: Ramesh Chandrasekharan, Easwar Srinivasan
  • Patent number: 12023493
    Abstract: A closed-loop spinal cord electrical stimulation system includes a spinal epidural electrical stimulation electrode, a low limb electrical stimulation electrode, a closed-loop electrical stimulator and a controller. The spinal epidural electrical stimulation electrode, the low limb electrical stimulation electrode and the controller are electrically connected to the closed-loop electrical stimulator respectively. The spinal epidural electrical stimulation electrode is used for applying a first electrical stimulation to the spinal epidural site, and the low limb electrical stimulation electrode is used for applying a second electrical stimulation to a low limb. The voltage of the first electric stimulation is 400-600 mV, the voltage of the second electric stimulation is 1 V-1.5 V, and the stimulation frequency of the both is 10-20 Hz.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: July 2, 2024
    Assignee: SOOCHOW UNIVERSITY
    Inventors: Yaobo Liu, Dan Yang, Wei Yang, Kai Zhou, Wei Wei, Hui Zhang
  • Patent number: 12011609
    Abstract: A wearable cardioverter defibrillator (WCD) system includes a processor, a memory, a wireless communication module (DWCM), and an NFC tag that stores information for how an accessing device may access the DWCM wirelessly. An accessing device such as a defibrillator configurator with an NFC reader may read the NFC tag of the WCD system, if it has adequate permission to do so. Upon so reading, the accessing device will know how to address the DWCM wirelessly, and thus install or update configuration data, software updates, or request memory downloads from operations. The use of the NFC tag requires close proximity, which hampers both inadvertently programming the wrong WCD system, plus a WCD system being attacked maliciously.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: June 18, 2024
    Assignee: West Affum Holdings DAC
    Inventors: Erik L. Schneider, Erick Michael Roane, Dusan Beblavy
  • Patent number: 11957897
    Abstract: Embodiments may provide a general-purpose, relatively inexpensive, AI-driven implant that is able to adapt to and modulate any given neuron, circuit, or region in the brain, as well as individual cells of any type of tissue. For example, in an embodiment, a method for interacting with living tissue may comprise attaching a device to a body of a person or animal, the device comprising plurality of carbon fibers in contact with the living tissue, receiving by the carbon fibers signals from the living tissue, processing the received signals by the device, and transmitting the processed signals.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: April 16, 2024
    Inventor: Newton Howard
  • Patent number: 11957895
    Abstract: The disclosed electrical stimulation system generates interventions to assist patients in complying with a diet. The wearable device includes a microprocessor, electrical stimulator and at least one electrode configured to deliver electrical stimulation to the epidermis, through a range of 0.1 mm to 10 mm or a range of 0.1 mm to 20 mm of the dermis, of a T2 dermatome to a T12 dermatome or meridian of the patient, a C5 to a T1 dermatome across the hand and/or arm, and/or the upper chest regions. The device is adapted to provide electrical stimulation as per stimulation protocols and to communicate wirelessly with a companion control device configured to monitor and record appetite patterns of the patient and deliver titrated therapy. The control device is also configured to monitor, record, and modify stimulation parameters of the stimulation protocols.
    Type: Grant
    Filed: February 7, 2023
    Date of Patent: April 16, 2024
    Inventors: Bevil Hogg, Raul E. Perez
  • Patent number: 11944813
    Abstract: An epicardial pacer wire management device can include a spool defining a recessed region that encompasses the spool. The recessed region can receive a portion of a pacer wire. The device can further include a connector attached to the spool, and the connector can be electrically coupled with an exposed tip of the pacer wire. The device can further include an electrical port attached to the spool that can communicate with a pacing control unit. The device may include an electrical communication line electrically coupled between the connector and the electrical port.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: April 2, 2024
    Inventors: Ian Nolan Hess, Cory Denton Smith, Rami Musa Shorti
  • Patent number: 11931593
    Abstract: Systems for destroying or inhibiting cancer cells and other rapidly-dividing cells including an alternating polarity (AP) magnetic field generator and at least one AP electromagnetic coil adapted to be coupled to a target body area, and a controller to control the AP magnetic field generator and at least one AP electromagnetic coil and cause the field generator and coil to apply AP magnetic field having a frequency of 0.5-500 kHz and a field strength of 0.5-5 mT to the target body area to achieve a desired inhibiting effect on cancer cells or other rapidly-dividing cells. Treatments provided by the system may be co-administered with an anti-cancer drug such as a chemotherapy drug, a hormone therapy drug, targeted therapy drugs, immunotherapy drugs, or an angiogenesis inhibitor drug.
    Type: Grant
    Filed: February 12, 2023
    Date of Patent: March 19, 2024
    Assignee: ASHA MEDICAL, INC.
    Inventor: Vivek K. Sharma
  • Patent number: 11918411
    Abstract: An exemplary diagnostic system may be configured to direct an acoustic stimulation generator to apply acoustic stimulation to a recipient of a cochlear implant during an insertion procedure in which an electrode lead coupled to the cochlear implant is supposed to be inserted into a cochlea of the recipient, direct the cochlear implant to use an electrode on the electrode lead to record an evoked response signal that occurs within the recipient in response to the acoustic stimulation, detect an anomaly in the evoked response signal, and determine, based on the anomaly, that the electrode lead is being inserted into a vestibular canal instead of into the cochlea.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: March 5, 2024
    Assignee: Advanced Bionics AG
    Inventors: Kanthaiah Koka, Leonid M. Litvak
  • Patent number: 11890109
    Abstract: Treatment controllers and methods are provided that can be integrated with treatment systems, such as peritoneal dialysis systems, hemodialysis systems, and nocturnal treatment systems, to manage execution of treatment operations or a course of treatment based on timing information and/or patient sleep state.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: February 6, 2024
    Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Daniel Schmidt, Bert D. Egley
  • Patent number: 11883650
    Abstract: A implantable neural electrode assembly is described. The implantable neural electrode assembly includes a plurality of open-ended rings alternatingly connected to a spine. An inner layer of the open-ended rings is formed from a drug-loaded material (e.g., silicone that has been loaded with a steroid) and an outer layer is formed from a drug-free material. One or more electrode assemblies are connected to the inner layer and oriented towards a center of a cylinder defined by the plurality of open-ended rings.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: January 30, 2024
    Assignee: Verily Life Sciences, LLC
    Inventors: Xianyan Wang, Cindy Au
  • Patent number: 11872446
    Abstract: A method for gait retraining of a runner includes: measuring acceleration data of at least one lower leg of the runner; diagnosing the acceleration data thereby determining a measure of the impact intensity of at least one external tibial shock; and providing real-time feedback to the runner by converting the measure of the impact intensity into distortion of music to a level which is perceived by the runner as a measure for the impact intensity. The conversion is done based on a predefined relationship between perceived distortion levels and imposed distortion levels, and the runner can reduce the distortion of the music by adjusting his or her gait.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: January 16, 2024
    Assignee: UNIVERSITEIT GENT
    Inventors: Dirk De Clercq, Marc Leman, Joren Six, Valerio Lorenzoni, Joeri Gerlo, Pieter Van Den Berghe
  • Patent number: 11865343
    Abstract: Methods for treating post-traumatic stress disorder (PTSD) and/or for reducing a risk associated with developing PTSD in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with PTSD as well as an increased risk of developing PTSD following a traumatic event. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to a PTSD status in the patient. Other aspects are directed to reducing a likelihood of developing PTSD in patients presenting one or more PTSD risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's PTSD status or risk of developing PTSD. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: January 9, 2024
    Assignee: Medtronic Ireland Manufacturing Unlimited Company
    Inventors: Marcia Gallagher, Douglas A. Hettrick
  • Patent number: 11850423
    Abstract: The invention discloses an electrochemical device for treating cancer, characterized by using an acupuncture needle as a working electrode to produce hydrogen in a tumor tissue, thereby destroying the tumor tissue through the produced hydrogen gas. The device of the invention has low cost and simple operation, can realize minimally invasive treatment, and is green and environmentally friendly.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: December 26, 2023
    Assignee: CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
    Inventors: Yongdong Jin, Guohua Qi, Bo Wang
  • Patent number: 11844944
    Abstract: A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: December 19, 2023
    Assignee: Flint Hills Scientfic, LLC.
    Inventor: Ivan Osorio
  • Patent number: 11839757
    Abstract: Contraction stimulation therapy can treat myriad diseases, including lymphedema using a skin patch or implantable stimulator that includes a multiplicity of electrodes, a processor, a stimulation circuit, one or more sensors and programming for a patient interface unit, wherein the processor is programmed to control selection of a subset of the multiplicity of electrodes and of operation of the stimulation circuit responsive to an indication of an adverse physiologic response. The indication of patient discomfort may be determined by monitoring a physiologic parameter of the subject using the one or more sensors, by direct input from the subject via the patient interface unit programming, or a combination thereof. The devices, systems and methods also provide for automatically optimizing the stimulation parameters applied by the stimulation circuit responsive to feedback from the one or more sensors and/or by using direct input from the subject.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: December 12, 2023
    Assignee: Iambic Science, LLC
    Inventor: Dan Sachs
  • Patent number: 11761019
    Abstract: A pharmaceutical composition suitable for preventing or treating cardiac arrhythmia is disclosed. The pharmaceutical composition contains, as an active ingredient, a CCN5 protein or a nucleotide encoding the CCN5 protein. The pharmaceutical composition inhibits the pathological activity of CaMKII, which induces cardiac electrical abnormalities that is the main cause of atrial arrhythmia and ventricular arrhythmia, so as to restore the electrical functions, and inhibits the activity of myofibroblasts causing structural abnormalities. Therefore, the pharmaceutical composition can be effectively used in the prevention or treatment of cardiac arrhythmia.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: September 19, 2023
    Assignee: BETHPHAGEN INC.
    Inventors: Min-Ah Lee, Tae Hwan Kwak, Woo Jin Park
  • Patent number: 11717336
    Abstract: An electrosurgical generator capable of supplying energy in a waveform that causes electroporation in biological tissue. The electrosurgical generator may comprise an electroporation waveform supply unit that is integrated with an electromagnetic signal supply unit for generating microwave electromagnetic signals and radiofrequency electromagnetic signals for treatment. The electrosurgical generator may be configured to deliver different types of energy along a common feed cable. The electroporation waveform supply unit comprises a DC power supply and a DC pulse generator. The DC power supply may include a DC-DC converter for up-converting a voltage output by an adjustable voltage supply. Each DC pulse may have a duration in the range 1 ns to 10 ms and a maximum amplitude in the range 10 V to 10 kV.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: August 8, 2023
    Assignee: CREO MEDICAL LIMITED
    Inventors: Christopher Paul Hancock, Malcolm White, John Bishop, Ilan Wyn Davies, Christopher Duff, George Hodgkins
  • Patent number: 11712296
    Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: August 1, 2023
    Assignee: Axon Therapies, Inc.
    Inventors: Dorin Panescu, Andrew Wu, Zoar Jacob Engelman, Mark Gelfand, Mark S. Leung, Howard Levin
  • Patent number: 11707612
    Abstract: An intelligent bioelectric module for use with a drug delivery system has a case and a set of at least two electrodes in electrical communication with a detection surface of the case. The case is configured so that, in use, the detection surface comes into electrical communication with (i) a second surface of the delivery system when a first surface of the delivery system has been put into contact with a tissue surface of a human or animal subject or (ii) the tissue surface that is adjacent to a portion contacted by the first surface of the delivery system or (iii) both the second surface and the tissue surface.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: July 25, 2023
    Assignee: Bioelectric Devices, Inc.
    Inventors: Michael Motion, Michel M. Maharbiz, Russell Potts
  • Patent number: 11691014
    Abstract: An Example of a system for providing a patient with pain management may include a sleep monitoring circuit, a pain relief device, and a control circuit. The sleep monitoring circuit may be configured to sense one or more sleep signals from the patient and to determine a sleep state of the patient using the one or more sleep signals. The one or more sleep signals may include one or more physiological signals corresponding to the sleep state of the patient. The pain relief device may be configured to deliver one or more pain relief therapies. The control circuit may be configured to control the delivery of the one or more pain relief therapies using therapy parameters and to adjust the therapy parameters based on the determined sleep state.
    Type: Grant
    Filed: March 1, 2021
    Date of Patent: July 4, 2023
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Kyle Harish Srivastava, Bryan Allen Clark, Elizabeth Mary Annoni, Jianwen Gu
  • Patent number: 11682474
    Abstract: A first set of user data is received and a user profile is constructed based on the user data and in accordance with a sensitive service involving the user. A situational context is analyzed based on the first set of data. Personalized questions are generated, responsive to the user profile and to the situational context. The personalized questions are presented to a user corresponding to the user data and responses to same are received, including detection of user micro-expressions. The responses are analyzed, according to one or more machine learning models. A neural network model selects an action to be performed in response to analyzing the responses from the user; the action is a sensitive service involving the user. An apparatus is triggered to send a simple message service (SMS) message to a point of care service professional; the message recommends performance of the sensitive service on the user.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: June 20, 2023
    Assignee: International Business Machines Corporation
    Inventors: Komminist Weldemariam, Srihari Sridharan, Geoffrey Henry Siwo, Nelson Kibichii Bore, Solomon Assefa
  • Patent number: 11673006
    Abstract: Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: June 13, 2023
    Assignee: Medtronic Ireland Manufacturing Unlimited Company
    Inventors: Paul Sobotka, Neil Barman
  • Patent number: 11638678
    Abstract: A vibrating gastrointestinal capsule and method of use thereof for treating Parkinsonism in a subject, the method including: (a) providing a vibrating gastrointestinal capsule having a housing; a vibrating agitation mechanism adapted such that, in a vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; and a power supply disposed within the housing and adapted to power the vibrating agitation mechanism; (b) ingesting the capsule, by the subject; and (c) controlling the vibrating agitation mechanism such that at least a portion of the vibrating mode of operation occurs within the stomach and/or the small intestine of the subject.
    Type: Grant
    Filed: April 7, 2019
    Date of Patent: May 2, 2023
    Assignee: Vibrant Ltd.
    Inventor: Lior Ben-Tsur
  • Patent number: 11638820
    Abstract: A neuromodulation system and a method of inducing voluntary movement in a mammal with a spinal injury are disclosed. In an example, a neuromodulation system includes a processor, a signal generator, and at least one electrode. The processor, in cooperation with the signal generator and the at least one electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation includes during a first time period, a transcutaneous electrical spinal cord stimulation (“tESCS”) applied to the mammal during physical conditioning of the mammal. The transcutaneous stimulation also includes during a second time period after the first time period, the tESCS applied to the mammal during reduced or no physical conditioning of the mammal. The tESCS applied during the first time period and the second time period is used to establish a functional baseline of the mammal.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: May 2, 2023
    Assignee: The Regents of the University of California
    Inventors: Victor Reggie Edgerton, Yury P. Gerasimenko, Parag Gad, Nicholas A. Terrafranca
  • Patent number: 11623085
    Abstract: Systems and methods for treating cancerous tumors (including glioblastoma multiforme (GBM)) with electrotherapy, such as deep brain stimulation (DBS) technology, as disclosed herein. One or more configurations can be generated based on a patients tumor characteristics. The selected configurations can be electrode configurations or settings for an electrical source coupled to the electrodes. The one or more configurations can be targeted for inhibiting cell growth process, such as to inhibit mitosis, immune suppression, or to inhibit DNA replication. Inhibition of cell growth processes can initiate death of the cancerous cells.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: April 11, 2023
    Assignee: Regents of the University of Minnesota
    Inventors: Clark C. Chen, Gregory Frederick Molnar
  • Patent number: 11602629
    Abstract: Systems and methods for a soft tissue treatment of a patient are provided herein. The device for a soft tissue treatment may include an applicator having at least one electrode, a fastening mechanism to fix the applicator to a body part of the patient, and a control unit having a microprocessor to control the at least one electrode. The at least one electrode may provide radiofrequency energy and pulsed electric current. The radiofrequency energy may cause a heating of a soft tissue. The electric current may cause contraction of a muscle within the body part. The body part may be a face.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: March 14, 2023
    Assignee: BTL Healthcare Technologies A.S.
    Inventors: Tomás Schwarz, Ondrej Prouza
  • Patent number: 11554210
    Abstract: An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: January 17, 2023
    Assignee: NeuroDerm, Ltd.
    Inventors: Eran Shor, Tsabar Mor, Tamir Ben David, Nir Lilach, Rami Grossfeld, Shai Alfandari, Ram Nadler, Dmitry Golom, Daniel Shaki, Yoav Tikochinsky, Serdar Ozsumer
  • Patent number: 11523768
    Abstract: A method of identifying an epileptogenic zone of a subjects brain includes: receiving a plurality N of physiological brain signals that extend over a duration, each of the plurality N of physiological brain signals acquired from the subjects brain; calculating within a time window a state transition matrix based on at least a portion of each of the plurality N of physiological brain signals, wherein the state transition matrix is a linear time invariant model of a network of N nodes corresponding to the plurality N of physiological brain signals; calculating a minimum norm of a perturbation on the state transition matrix that causes the network to transition from a stable state to an unstable state; and assigning a fragility metric to each of the plurality N of physiological brain signals based on the minimum norm of the perturbation for that physiological brain signal.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: December 13, 2022
    Assignees: The Johns Hopkins University, The Cleveland Clinic Foundation
    Inventors: Sridevi Sarma, Adam Li, Jorge Gonzalez-Martinez
  • Patent number: 11504524
    Abstract: A multi-site probe for interfacing with the central nervous system includes one more structures disposed perpendicularly on a backing layer, where each structure includes a braided sleeve over a flexible or rigid core, and a delivery-vehicle. The structures may include optrodes and electrodes. The location of the probe may be determined through the application of combinatorics.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: November 22, 2022
    Assignee: Drexel University
    Inventor: Simon Francis Giszter
  • Patent number: 11504523
    Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing, a first prong with a proximal end attached to the housing and a distal end extending away from the housing, and a first electrode on the first prong. The clip is configured to anchor the device to a muscle, a bone, and/or a tissue. The first prong is configured to contact a heart. The first electrode is configured to contact the heart. Sensing circuitry in the housing that is configured to sense an electrical signal from the heart, and therapeutic circuitry in the housing is in electrical communication with the first electrode and is configured to deliver electrical stimulation to the heart through the first electrode.
    Type: Grant
    Filed: January 18, 2021
    Date of Patent: November 22, 2022
    Assignee: Manicka Institute LLC
    Inventor: Yatheendhar D. Manicka
  • Patent number: 11491080
    Abstract: A system for generating stimulations in relation to medicines, and meridians, organs and tissues of a human body includes a control device, a pulse examining device and a stimulation device. Based on a pulsation signal obtained from a user, the stimulation device obtains a meridian-related spectrum. Based on operation input to the control device, the stimulation device obtains an organ-tissue-related spectrum and a medication-related spectrum. The stimulation device obtains a stimulation spectrum by making a linear combination of these spectrums, and stimulates a sensory system of the user based on the stimulation spectrum.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: November 8, 2022
    Inventor: Kuang-Cheng Chao
  • Patent number: 11420048
    Abstract: A device and method for rejuvenating skin includes a power supply adapted to generate a voltage and an applicator. The applicator includes a first node and a second node, wherein the first node is adapted to be configurable between a positive electrode or electrically isolated from the power supply, and wherein the second node is adapted to be configurable between a negative electrode or electrically isolated from the power supply. The power supply delivers a current through the first node when the first node is configured as the positive electrode and current returns to the power supply through the second node when the second node is configured to be the negative electrode.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: August 23, 2022
    Assignee: HER TECHNOLOGIES INC.
    Inventors: Mark Campbell, Thomas Murphy
  • Patent number: 11406528
    Abstract: The present disclosure relates to a cold and hot thermal treatment device. Hot heat and cold heat are produced by a heat production unit and are periodically and repeatedly transferred to a heat transfer unit that is in contact with a human body such that a temperature is not suddenly changed but is gradually changed. Thus, the device may be used when diagnosing whether vascular reactivity is maintained in corresponding hands and feet, may generate a temperature stimulus, and may repeatedly perform the temperature stimulus, thereby improving the vascular reactivity.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: August 9, 2022
    Assignee: Industrial Cooperation Foundation Chonbuk National University
    Inventor: Hwan Jeong Jeong
  • Patent number: 11400269
    Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: August 2, 2022
    Assignee: Novocure GmbH
    Inventors: Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
  • Patent number: 11357432
    Abstract: System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals from the signal detector, and apply a filter to the received electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subject's skin.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: June 14, 2022
    Assignee: INDIANA UNIVERSTTY RESEARCH & TECHNOLOGY CORPORATION
    Inventor: Peng-Sheng Chen
  • Patent number: 11344726
    Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: May 31, 2022
    Assignee: SPR Therapeutics, Inc.
    Inventors: Maria E. Bennett, Joseph W. Boggs, Warren M. Grill, John Chae
  • Patent number: 11324943
    Abstract: Methods and devices for stimulating a nerve in a patient include positioning a device adjacent an outer skin surface of the patient and emitting an electrical field near the vagus nerve within the patient. The electric field is varied to create burst periods and constant periods. The charge of the electric field emitted during the burst periods alternates between positive and negative. The charge of the electric field emitted during the constant periods has a magnitude of zero.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: May 10, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11305113
    Abstract: Example inventions reduce nocturia for a user. Examples determine that the user is sleeping, determine that the user has an urge to urinate, and then apply external electrical stimulation to a tibial nerve of the user.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 19, 2022
    Assignee: NEUROSTIM SOLUTIONS LLC
    Inventor: Hoo-Min D. Toong
  • Patent number: 11284804
    Abstract: In various embodiments, a wearable non-invasive apparatus for enhancing lower limb venous return of a subject may be provided. The apparatus may include a monitoring device configured to determine a venous state of a subject such as a photoplethysmography (PPG) sensor. The apparatus may also include a neuromuscular electrical stimulation (NMES) device configured to generate an electrical stimulus in response to the determinedvenous state and concurrently stimulate the triceps surae and the deep posterior calf muscle of the subject with the generated electrical stimulus to enhance lower limb venous return. In an alternative embodiment, electrical stimulation can be at the tibial nerve of the subject to retrograde target the triceps surae and the deep posterior calf muscle of the subject.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: March 29, 2022
    Assignee: Agency for Science, Technology and Research
    Inventors: Xu Wen Ng, Wan Loong James Mok, Enci Mary Kan, Ka Mung Chee
  • Patent number: 11278766
    Abstract: A rehabilitation system according to an embodiment of the present invention includes a wearable device for measuring rehabilitation exercise information of a user and a user electronic device receiving the rehabilitation exercise information from the wearable device and driving an avatar training program. The user electronic device may receive the avatar training program recommended based on user personal information and the rehabilitation exercise information from a rehabilitation program recommendation server. According to the present invention, a rehabilitation effect can be enhanced by performing a rehabilitation exercise according to a rehabilitation program suitable for a user using a wearable device and a user electronic device.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: March 22, 2022
    Assignee: EXOSYSTEMS INC.
    Inventor: Hooman Lee
  • Patent number: 11278344
    Abstract: [Problem] To provide a power feed system that supplies electric power via electromagnetic waves to an implant embedded in a deep part of a living body, using a sandwiching method in which a potential difference is generated using a pair of electrodes, by disposing an implant electronic device between a power transmission side electrode and a power reception side electrode. [Solution] It is provided with: a pair of electrodes (a first surface electrode 3 and a second surface electrode 4) stuck onto a surface of a living body 6; an implant electronic device 2 that includes a first body internal electrode 30 and a second body internal electrode 40 and in which the first body internal electrode 30 and the second body internal electrode 40 are fixed to respective positions having different potential differences in the living body 6; and a high frequency AC power source 5 that applies a high frequency alternating voltage to the first surface electrode 3 and the second surface electrode 4.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 22, 2022
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Tetsuo Ikeda, Haruichi Kanaya, Ryosuke Tsutsumi
  • Patent number: 11246748
    Abstract: Disclosed is an applicator device for an apparatus used in a localized cryotherapy treatment. The applicator device is configured, when positioned over a body area to be treated, to receive and to uniformly distribute across the entire area covered thereby a stream of medium, such as air, adjusted to a temperature equal to or above ?40 degrees Celsius (° C.) and directed, at a predetermined speed, via the applicator to the area to be treated, whereby a cold-induced thermal shock response is developed in skin and an underlying tissue within the area covered by the applicator. Related apparatus and a method are further provided.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: February 15, 2022
    Assignee: CRYOTECH NORDIC AS
    Inventor: Jean-Patrick Martins
  • Patent number: 11247039
    Abstract: A method of a soft tissue treatment comprises placing an applicator adjacent to a surface of a body part, the applicator including at least one electrode, providing a fastening mechanism fixing the applicator in contact with the body part, providing a radiofrequency energy by the at least one electrode causing a heating of the soft tissue, providing an electric current to the soft tissue by the at least one electrode causing a muscle contraction, and controlling heating of the soft tissue by the radiofrequency energy and parameters of the electric current provided by the at least one electrode via a control unit, wherein an energy flux density of the radiofrequency energy is in a range of 0.01 mW·mm?2 to 10 W·mm?2 and a frequency of the radiofrequency energy is in a range of 0.1 MHz to 25 GHz, and wherein the body part comprises a face or a chin.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 15, 2022
    Assignee: BTL Healthcare Technologies a.s.
    Inventor: Tomá{hacek over (s)} Schwarz
  • Patent number: 11202906
    Abstract: A skin treatment device, adapted for delivery of an active ingredient into the human skin by means of iontophoresis, the device having electrodes to establish an electric field on the human skin, wherein the device includes an array of n electrodes with at least a first and a second electrode.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: December 21, 2021
    Assignee: FEELIGREEN SA
    Inventors: Abdelwahhab Yakoub, Christophe Bianchi
  • Patent number: 11185690
    Abstract: A device providing treatment by radiofrequency field and electrotherapy to a patient comprises a control unit and an applicator comprising at least one radiofrequency electrode providing a radiofrequency field having a frequency in a range of 0.1 MHz to 25 GHz and an energy flux density in a range of 0.01 mW·mm?2 to 10 W·mm?2 configured to heat a body part of the patient, and at least one electrotherapy electrode providing an electric current causing contraction of a muscle of the body part of the patient, wherein the applicator is configured to be stationary during treatment and to be fixed in contact with a body of the patient. Additional devices providing treatment by radiofrequency field and electrotherapy to a patient and a method of treatment of a patient by radiofrequency and electrotherapy are also described.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: November 30, 2021
    Assignee: BTL Healthcare Technologies, a.s.
    Inventor: Tomás Schwarz
  • Patent number: 11187226
    Abstract: An actuating-type gas guiding device includes a main body and a piezoelectric actuator. The piezoelectric actuator is disposed in the main body. The piezoelectric actuator includes a suspension plate, an outer frame, at least one bracket and a piezoelectric element. The suspension plate has a first surface and a second surface. The suspension plate is permitted to undergo a bending vibration. The outer frame is arranged around the suspension plate. The at least one bracket is connected between the suspension plate and the outer frame for elastically supporting the suspension plate. The piezoelectric element is attached on the first surface of the suspension plate. In response to a voltage applied to the piezoelectric element, the suspension plate is driven to undergo the bending vibration in a reciprocating manner. Consequently, gas is guided to flow in the main body along a non-scattered linear direction.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 30, 2021
    Assignee: MICROJET TECHNOLOGY CO., LTD.
    Inventors: Hao-Jan Mou, Chi-Feng Huang, Yung-Lung Han, Chang-Yen Tsai, Wei-Ming Lee, Hsuan-Kai Chen