Combined With Nonelectrical Therapy Patents (Class 607/3)
  • Patent number: 11504523
    Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing, a first prong with a proximal end attached to the housing and a distal end extending away from the housing, and a first electrode on the first prong. The clip is configured to anchor the device to a muscle, a bone, and/or a tissue. The first prong is configured to contact a heart. The first electrode is configured to contact the heart. Sensing circuitry in the housing that is configured to sense an electrical signal from the heart, and therapeutic circuitry in the housing is in electrical communication with the first electrode and is configured to deliver electrical stimulation to the heart through the first electrode.
    Type: Grant
    Filed: January 18, 2021
    Date of Patent: November 22, 2022
    Assignee: Manicka Institute LLC
    Inventor: Yatheendhar D. Manicka
  • Patent number: 11504524
    Abstract: A multi-site probe for interfacing with the central nervous system includes one more structures disposed perpendicularly on a backing layer, where each structure includes a braided sleeve over a flexible or rigid core, and a delivery-vehicle. The structures may include optrodes and electrodes. The location of the probe may be determined through the application of combinatorics.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: November 22, 2022
    Assignee: Drexel University
    Inventor: Simon Francis Giszter
  • Patent number: 11491080
    Abstract: A system for generating stimulations in relation to medicines, and meridians, organs and tissues of a human body includes a control device, a pulse examining device and a stimulation device. Based on a pulsation signal obtained from a user, the stimulation device obtains a meridian-related spectrum. Based on operation input to the control device, the stimulation device obtains an organ-tissue-related spectrum and a medication-related spectrum. The stimulation device obtains a stimulation spectrum by making a linear combination of these spectrums, and stimulates a sensory system of the user based on the stimulation spectrum.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: November 8, 2022
    Inventor: Kuang-Cheng Chao
  • Patent number: 11420048
    Abstract: A device and method for rejuvenating skin includes a power supply adapted to generate a voltage and an applicator. The applicator includes a first node and a second node, wherein the first node is adapted to be configurable between a positive electrode or electrically isolated from the power supply, and wherein the second node is adapted to be configurable between a negative electrode or electrically isolated from the power supply. The power supply delivers a current through the first node when the first node is configured as the positive electrode and current returns to the power supply through the second node when the second node is configured to be the negative electrode.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: August 23, 2022
    Assignee: HER TECHNOLOGIES INC.
    Inventors: Mark Campbell, Thomas Murphy
  • Patent number: 11406528
    Abstract: The present disclosure relates to a cold and hot thermal treatment device. Hot heat and cold heat are produced by a heat production unit and are periodically and repeatedly transferred to a heat transfer unit that is in contact with a human body such that a temperature is not suddenly changed but is gradually changed. Thus, the device may be used when diagnosing whether vascular reactivity is maintained in corresponding hands and feet, may generate a temperature stimulus, and may repeatedly perform the temperature stimulus, thereby improving the vascular reactivity.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: August 9, 2022
    Assignee: Industrial Cooperation Foundation Chonbuk National University
    Inventor: Hwan Jeong Jeong
  • Patent number: 11400269
    Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: August 2, 2022
    Assignee: Novocure GmbH
    Inventors: Carsten Hagemann, Mario Lohr, Almuth F. Kessler, Malgorzata Burek, Carola Forster, Catherine Brami, Hadas Sara Hershkovich, Tali Voloshin-Sela
  • Patent number: 11357432
    Abstract: System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals from the signal detector, and apply a filter to the received electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subject's skin.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: June 14, 2022
    Assignee: INDIANA UNIVERSTTY RESEARCH & TECHNOLOGY CORPORATION
    Inventor: Peng-Sheng Chen
  • Patent number: 11344726
    Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: May 31, 2022
    Assignee: SPR Therapeutics, Inc.
    Inventors: Maria E. Bennett, Joseph W. Boggs, Warren M. Grill, John Chae
  • Patent number: 11324943
    Abstract: Methods and devices for stimulating a nerve in a patient include positioning a device adjacent an outer skin surface of the patient and emitting an electrical field near the vagus nerve within the patient. The electric field is varied to create burst periods and constant periods. The charge of the electric field emitted during the burst periods alternates between positive and negative. The charge of the electric field emitted during the constant periods has a magnitude of zero.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: May 10, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 11305113
    Abstract: Example inventions reduce nocturia for a user. Examples determine that the user is sleeping, determine that the user has an urge to urinate, and then apply external electrical stimulation to a tibial nerve of the user.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 19, 2022
    Assignee: NEUROSTIM SOLUTIONS LLC
    Inventor: Hoo-Min D. Toong
  • Patent number: 11284804
    Abstract: In various embodiments, a wearable non-invasive apparatus for enhancing lower limb venous return of a subject may be provided. The apparatus may include a monitoring device configured to determine a venous state of a subject such as a photoplethysmography (PPG) sensor. The apparatus may also include a neuromuscular electrical stimulation (NMES) device configured to generate an electrical stimulus in response to the determinedvenous state and concurrently stimulate the triceps surae and the deep posterior calf muscle of the subject with the generated electrical stimulus to enhance lower limb venous return. In an alternative embodiment, electrical stimulation can be at the tibial nerve of the subject to retrograde target the triceps surae and the deep posterior calf muscle of the subject.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: March 29, 2022
    Assignee: Agency for Science, Technology and Research
    Inventors: Xu Wen Ng, Wan Loong James Mok, Enci Mary Kan, Ka Mung Chee
  • Patent number: 11278344
    Abstract: [Problem] To provide a power feed system that supplies electric power via electromagnetic waves to an implant embedded in a deep part of a living body, using a sandwiching method in which a potential difference is generated using a pair of electrodes, by disposing an implant electronic device between a power transmission side electrode and a power reception side electrode. [Solution] It is provided with: a pair of electrodes (a first surface electrode 3 and a second surface electrode 4) stuck onto a surface of a living body 6; an implant electronic device 2 that includes a first body internal electrode 30 and a second body internal electrode 40 and in which the first body internal electrode 30 and the second body internal electrode 40 are fixed to respective positions having different potential differences in the living body 6; and a high frequency AC power source 5 that applies a high frequency alternating voltage to the first surface electrode 3 and the second surface electrode 4.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 22, 2022
    Assignee: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Tetsuo Ikeda, Haruichi Kanaya, Ryosuke Tsutsumi
  • Patent number: 11278766
    Abstract: A rehabilitation system according to an embodiment of the present invention includes a wearable device for measuring rehabilitation exercise information of a user and a user electronic device receiving the rehabilitation exercise information from the wearable device and driving an avatar training program. The user electronic device may receive the avatar training program recommended based on user personal information and the rehabilitation exercise information from a rehabilitation program recommendation server. According to the present invention, a rehabilitation effect can be enhanced by performing a rehabilitation exercise according to a rehabilitation program suitable for a user using a wearable device and a user electronic device.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: March 22, 2022
    Assignee: EXOSYSTEMS INC.
    Inventor: Hooman Lee
  • Patent number: 11246748
    Abstract: Disclosed is an applicator device for an apparatus used in a localized cryotherapy treatment. The applicator device is configured, when positioned over a body area to be treated, to receive and to uniformly distribute across the entire area covered thereby a stream of medium, such as air, adjusted to a temperature equal to or above ?40 degrees Celsius (° C.) and directed, at a predetermined speed, via the applicator to the area to be treated, whereby a cold-induced thermal shock response is developed in skin and an underlying tissue within the area covered by the applicator. Related apparatus and a method are further provided.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: February 15, 2022
    Assignee: CRYOTECH NORDIC AS
    Inventor: Jean-Patrick Martins
  • Patent number: 11247039
    Abstract: A method of a soft tissue treatment comprises placing an applicator adjacent to a surface of a body part, the applicator including at least one electrode, providing a fastening mechanism fixing the applicator in contact with the body part, providing a radiofrequency energy by the at least one electrode causing a heating of the soft tissue, providing an electric current to the soft tissue by the at least one electrode causing a muscle contraction, and controlling heating of the soft tissue by the radiofrequency energy and parameters of the electric current provided by the at least one electrode via a control unit, wherein an energy flux density of the radiofrequency energy is in a range of 0.01 mW·mm?2 to 10 W·mm?2 and a frequency of the radiofrequency energy is in a range of 0.1 MHz to 25 GHz, and wherein the body part comprises a face or a chin.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 15, 2022
    Assignee: BTL Healthcare Technologies a.s.
    Inventor: Tomá{hacek over (s)} Schwarz
  • Patent number: 11202906
    Abstract: A skin treatment device, adapted for delivery of an active ingredient into the human skin by means of iontophoresis, the device having electrodes to establish an electric field on the human skin, wherein the device includes an array of n electrodes with at least a first and a second electrode.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: December 21, 2021
    Assignee: FEELIGREEN SA
    Inventors: Abdelwahhab Yakoub, Christophe Bianchi
  • Patent number: 11185690
    Abstract: A device providing treatment by radiofrequency field and electrotherapy to a patient comprises a control unit and an applicator comprising at least one radiofrequency electrode providing a radiofrequency field having a frequency in a range of 0.1 MHz to 25 GHz and an energy flux density in a range of 0.01 mW·mm?2 to 10 W·mm?2 configured to heat a body part of the patient, and at least one electrotherapy electrode providing an electric current causing contraction of a muscle of the body part of the patient, wherein the applicator is configured to be stationary during treatment and to be fixed in contact with a body of the patient. Additional devices providing treatment by radiofrequency field and electrotherapy to a patient and a method of treatment of a patient by radiofrequency and electrotherapy are also described.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: November 30, 2021
    Assignee: BTL Healthcare Technologies, a.s.
    Inventor: Tomás Schwarz
  • Patent number: 11187226
    Abstract: An actuating-type gas guiding device includes a main body and a piezoelectric actuator. The piezoelectric actuator is disposed in the main body. The piezoelectric actuator includes a suspension plate, an outer frame, at least one bracket and a piezoelectric element. The suspension plate has a first surface and a second surface. The suspension plate is permitted to undergo a bending vibration. The outer frame is arranged around the suspension plate. The at least one bracket is connected between the suspension plate and the outer frame for elastically supporting the suspension plate. The piezoelectric element is attached on the first surface of the suspension plate. In response to a voltage applied to the piezoelectric element, the suspension plate is driven to undergo the bending vibration in a reciprocating manner. Consequently, gas is guided to flow in the main body along a non-scattered linear direction.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 30, 2021
    Assignee: MICROJET TECHNOLOGY CO., LTD.
    Inventors: Hao-Jan Mou, Chi-Feng Huang, Yung-Lung Han, Chang-Yen Tsai, Wei-Ming Lee, Hsuan-Kai Chen
  • Patent number: 11179322
    Abstract: Viability of cancer cells (e.g., hepatocellular carcinoma cells) can be reduced by administering sorafenib to the cancer cells and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Viability of cancer cells (e.g., hepatocellular carcinoma cells) disposed in a body of a living subject can be reduced by administering sorafenib to the subject and applying an alternating electric field with a frequency between 100 and 400 kHz to the cancer cells. Notably, experiments show that the combination of sorafenib and the alternating electric field produces synergistic results both in vitro and in vivo.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: November 23, 2021
    Assignee: Novocure GmbH
    Inventors: Karnit Gotlib, Einav Zeevi, Rosa S. Schnaiderman, Tali Voloshin-Sela, Moshe Giladi, Adrian Kinzel, Eilon Kirson, Uri Weinberg, Yoram Palti, Shiri Davidi
  • Patent number: 11179270
    Abstract: Devices and methods are provided for the treatment of pathological conditions including arrhythmias and trauma using temperature modulation via implantable or worn devices. For example, in one example embodiment this document relates to devices and methods for treating atrial or ventricular fibrillation by cooling the epicardium. The devices and methods can also be used to treat other disorders by applying heating and/or cooling to a patient in a number of different manners.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: November 23, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman, Douglas S. Beinborn
  • Patent number: 11154717
    Abstract: An indication that a patient event occurred may be used to evaluate the efficacy of at least one therapy program and/or adjust therapy delivery to the patient. In some examples, the patient event indication includes patient input that may be received via an event indication button of a programming device. In some examples, therapy delivery may be adjusted by adjusting at least one therapy parameter value, switching therapy programs or therapy program groups or restarting a therapy cycle of a medical device.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: October 26, 2021
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Peter J. Kovach, Warren W. Ball, Jonathan C. Werder, Nina M. Graves, David C. Ullestad, Sarah B. Alme
  • Patent number: 11141219
    Abstract: A method of treating tissue of a patient uses a device including a mother case, a belt, at least one treatment unit and at least two applicators. The treatment method may include attaching first and second applicators to the belt at a working distance to the patient's surface, and providing different treatment energy to the first applicator and the second applicator. A treatment pattern is created by the applicators providing the different treatment energies. The hardware pattern or positions of the applicators on the belt may be changed before and/or during the treatment. The hardware pattern may be based on selected treatment effect and body part.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: October 12, 2021
    Assignee: BTL Healthcare Technologies, a.s.
    Inventor: Tomás̆ Schwarz
  • Patent number: 11116962
    Abstract: A method of a soft tissue treatment comprises placing an applicator adjacent to a surface of a body part, the applicator including at least one electrode, providing a fastening mechanism fixing the applicator in contact with the body part, providing a radiofrequency energy by the at least one electrode causing a heating of the soft tissue, providing an electric current to the soft tissue by the at least one electrode causing a muscle contraction, and controlling heating of the soft tissue by the radiofrequency energy and parameters of the electric current provided by the at least one electrode via a control unit, wherein an energy flux density of the radiofrequency energy is in a range of 0.01 mW·mm?2 to 10 W·mm?2 and a frequency of the radiofrequency energy is in a range of 0.1 MHz to 25 GHz, and wherein the body part comprises a face or a chin.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: September 14, 2021
    Assignee: BTL Healthcare Technologies a.s.
    Inventors: Ondrej Prouza, Tomá{hacek over (s)} Schwarz
  • Patent number: 11089998
    Abstract: A device and method for increasing a patient's compliance with a therapy relating to an upper airway disorder includes a receiving unit, a processing unit, and a display unit. The receiving unit is configured to receive vital sign data including glucose level data of the patient, and therapy data including information regarding the therapy of the patient. The processing unit is configured to process the therapy data and the vital sign data in order to determine feedback information based on the therapy data and the vital sign data. Lastly, the display unit is configured to display the feedback information based on the therapy data and the vital sign data.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: August 17, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Mareike Klee, Jacob Roger Haartsen, Mark Steven Aloia, Richard Andrew Sofranko, David Smith
  • Patent number: 11071860
    Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: July 27, 2021
    Assignee: ONCOSEC MEDICAL INCORPORATED
    Inventors: John Rodriguez, Jason Jin, Brandon Dang Phung, Wesley Joel Ericson, Jodie Marie Houdek, Jonathan Joseph McIntosh, Carlos E. Gonzalez, Anthony Steven Nault
  • Patent number: 11065448
    Abstract: Devices and methods to deliver microcurrent stimulation therapy to the human body, when connected to a micro-stimulation current-generating apparatus. The method of applying microcurrent stimulation therapy to key points around the eye for treatment of problems such as macular degeneration, retinitis pigmentosa, glaucoma, optic neuritis and other eye-related or nerve-related conditions, as well as other diseases, such as Bell's Palsy, requiring localized stimulation to the eyes and/or on other body parts.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: July 20, 2021
    Assignee: i-Lumen Scientific, Inc.
    Inventors: Blair P. Mowery, Marshall T. Masko, John B. Jarding, Gary A. Tapp
  • Patent number: 11045130
    Abstract: The present disclosure relates to measuring biosignals (particularly, electroencephalogram) of fish in a non-invasive and multi-channels manner, with a multi-channel electrode array of one or more conductive plates non-invasively attached to the epidermis of the fish outside of the water a; a reference electrode non-invasively attached to the epidermis of the fish outside of the surface of the water; a supply device that supplies a predetermined material and oxygen to the fish outside of the water; and a minute tube inserted into the oral cavity of the fish outside of the water to resuscitate the fish in a stable state to generate normal electroencephalogram.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 29, 2021
    Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE & TECHNOLOGY
    Inventor: So Hee Kim
  • Patent number: 11037260
    Abstract: A system includes a processor coupled to a memory. The processor and memory are configured to, during an emergency situation, initiate presentation, on a user interface, of information indicative of a location of one or more shelters. The processor and memory are configured to, during the emergency situation, receive, from a server, data indicative of actual occupancy of at least one of the one or more shelters. The processor and memory are configured to enable a rescuer to access information, through the user interface, about one or more of a potential occupancy and the actual occupancy of the at least one of the one or more shelters.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 15, 2021
    Assignee: ZOLL Medical Corporation
    Inventor: Guy R. Johnson
  • Patent number: 11027092
    Abstract: A device for replicating a natural magnetic vibration of Earth, promoting more restful sleep. The device produces an appropriately uniform magnetic field across the surface of the area where the head rests during sleep. The device provides a varying magnetic field therapy that allows a user to sleep in their usual manner using their existing familiar pillow, with no changes to the aesthetics of the bed, while using the device having varying magnetic field therapy capabilities.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 8, 2021
    Inventor: Paul M. Bode
  • Patent number: 11020051
    Abstract: Methods of enhancing homeostatic capacity in a subject are provided. Aspects of the methods include modulating synchrony, e.g., via modulating communication and/or coordination, among two or more distinct homeostatic systems of the subject in a manner sufficient to enhance homeostatic capacity of the subject. Also provided are devices configured for use in practicing the methods. Aspects of the invention further include methods of treating a subject for a condition via enhancement of homeostatic capacity. The methods and devices described herein find use in a variety of applications.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: June 1, 2021
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Conrad Minkyoo Yun
  • Patent number: 10960201
    Abstract: Methods and devices are provided for inhibiting nerves when activating brown adipose tissue (BAT). In general, a first nerve type (e.g., sympathetic nerves) innervating BAT can be activated while at least one other nerve type (e.g., parasympathetic nerves and/or sensory nerves) innervating BAT is being suppressed. A first neuromodulator (e.g., an electrical signal, a chemical, a light, cooling, etc.) can be applied to activate the first nerve type, and a second neuromodulator can be applied to inhibit the at least one other nerve type. In this way, parasympathetic nerves and/or sensory nerves innervating BAT can be inhibited when activating sympathetic nerves innervating BAT.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: March 30, 2021
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Tamara C. Baynham
  • Patent number: 10960210
    Abstract: An Example of a system for providing a patient with pain management may include a sleep monitoring circuit, a pain relief device, and a control circuit. The sleep monitoring circuit may be configured to sense one or more sleep signals from the patient and to determine a sleep state of the patient using the one or more sleep signals. The one or more sleep signals may include one or more physiological signals corresponding to the sleep state of the patient. The pain relief device may be configured to deliver one or more pain relief therapies. The control circuit may be configured to control the delivery of the one or more pain relief therapies using therapy parameters and to adjust the therapy parameters based on the determined sleep state.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 30, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Kyle Harish Srivastava, Bryan Allen Clark, Elizabeth Mary Annoni, Jianwen Gu
  • Patent number: 10952666
    Abstract: Treatment controllers and methods are provided that can be integrated with treatment systems, such as peritoneal dialysis systems, hemodialysis systems, and nocturnal treatment systems, to manage execution of treatment operations or a course of treatment based on timing information and/or patient sleep state.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 23, 2021
    Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Daniel Schmidt, Bert D. Egley
  • Patent number: 10918880
    Abstract: A method and apparatus for treatment of chronic kidney disease (CKD), particular diabetic nephropathy, are disclosed. The method comprises activation of adenosine A2a receptors in parenchymal and immune cells infiltrated into kidneys. The activation is performed by PEMF (pulsed electromagnetic field) stimulation applied locally to kidneys. Adenosine A2a signaling pathway is a potent anti-inflammatory and immuno-suppressive regulator that has been proven to attenuate inflammation and injury in diabetic nephropathy. Efficient activation of A2a receptors is achieved by applying electromagnetic field stimulation consecutively in 3 spatial dimensions. This allows attaining a significant increase in activation of A2a receptors in comparison with one-dimensional stimulation. Assistant thermal stimulation may be applied to increase expression of heat shock proteins (HSPs) in parenchymal cells.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: February 16, 2021
    Assignee: Minnesota Medical Physics LLC
    Inventors: Victor Ivan Chornenky, Ali Jaafar
  • Patent number: 10893805
    Abstract: For characterizing spatial-temporal dynamics of a medium (1) excitable for deformation, an elastic model of the medium is defined. The medium is imaged at consecutive points in time to obtain a series of images. Shifts of structures of the medium (1) between the images of the series are determined. A dynamic description of a temporal development of spatial deformations of a predefined elastic model of the medium (1) is adapted to match the shifts of the structures; and temporal developments of rate of deformation patterns in the medium (1) are identified from the dynamic description.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 19, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Stefan Luther, Jan Christoph
  • Patent number: 10870006
    Abstract: An apparatus for applying at least one electric pulse to a living myocardial tissue comprises an input configured to receive an electric signal representing a present electric activity of the myocardial tissue; a signal processor configured to process the electric signal to calculate a present permutation value of the electric signal in the state space and to only output a control signal when the calculated present entropy value of the electric signal is lower than a predetermined entropy threshold value; a pulse generator configured to generate the at least one electric pulse in response to the control signal; and an output configured to output the at least one electric pulse to the myocardial tissue.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 22, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Alexander Schlemmer, Thomas Lilienkamp, Sebastian Berg, Ulrich Parlitz, Stefan Luther
  • Patent number: 10857355
    Abstract: A direct current delivery device includes a direct current source or a device for connecting to a direct current source, and a first electrode and a second electrode for connecting to the direct current source, wherein the first electrode is configured as a plurality of needles and the second electrode is configured as a planar electrode, as a needle or a plurality of needles directly connected to one another in an electrically conductive manner. The direct current delivery device includes one or more devices configured to maintain the current intensity constant during the individual delivery of direct current through the needles of the first electrode.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 8, 2020
    Inventor: Albrecht Molsberger
  • Patent number: 10806927
    Abstract: This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: October 20, 2020
    Assignee: The Regents of the University of California
    Inventors: V. Reggie Edgerton, Yury Gerasimenko, Roland R. Roy, Daniel C. Lu
  • Patent number: 10799695
    Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 13, 2020
    Assignee: Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Janusz Kuzma
  • Patent number: 10799708
    Abstract: Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: October 13, 2020
    Assignee: NeuroSteer Ltd.
    Inventor: Nathan Intrator
  • Patent number: 10786610
    Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: September 29, 2020
    Assignee: TC1 LLC
    Inventor: Zijing Zeng
  • Patent number: 10786676
    Abstract: Described here is a deep brain stimulation (“DBS”) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 29, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Gregory Frederick Molnar, Luke Johnson, David Escobar Sanabria, Edward Mark Bello, II, Jerrold L. Vitek, Matthew D. Johnson
  • Patent number: 10772561
    Abstract: Various embodiments relate generally to electrical and electronic hardware, computer software and systems, and wired and wireless network communications to provide an interface between an organism and other computing machine-based entities, and, more specifically, to sensors that facilitate determination of a state of neural activity with which to associate data representing, for example, an intent and/or a command; to implementations of sensors under control to, for example, modify sensing characteristics to interpolate response signals spatially or temporally, or both, to facilitate determination of a state of neural activity; to the formation or implementation of a data model that includes, for example, data arrangements representative of at least neuronal activity to facilitate determination of a state of neural activity; and to mobile human-machine interface to facilitate control based on neuronal activity of an organism.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: September 15, 2020
    Inventor: Thomas Alan Donaldson
  • Patent number: 10758739
    Abstract: Brain dysfunction can be treated by restructuring neural pathways in the brain. A desired area in the brain to form a new neural pathway is selected. The area receives a sequential combination of (1) transcranial photobiomodulation therapy (PBMT) including a series of pulses having a frequency matched to a target brain wave and (2) another transcranial stimulation (e.g., transcranial direct current electrical stimulation and/or transcranial magnetic stimulation). The different stimulation mechanisms ensure that neuroplasticity occurs to restructure a neural pathway that is dysfunctional in nature to a new neural pathway that conducts normally.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: September 1, 2020
    Assignee: MULTI RADIANCE MEDICAL
    Inventors: Douglas Johnson, Max Kanarsky
  • Patent number: 10729350
    Abstract: A patient monitoring system for monitoring cardiac arrhythmias includes an ECG monitor configured to monitor cardiac potentials during cardiac cycles and an arterial blood flow monitor configured to monitor arterial blood flow and generate pulse waveform. The system further includes an arrhythmia detection module that detects the presence of an arrhythmia based on the cardiac potentials and generates an arrhythmia indicator, and an arrhythmia analysis module that assesses the severity of the detected arrhythmia. The arrhythmia analysis module calculates average sinus pulse information based on the pulse waveform data for two or more cardiac cycles occurring when no arrhythmia is detected, and then calculates average arrhythmia pulse information based on pulse waveform data for two or more cardiac cycles occurring after detection of the arrhythmia.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 4, 2020
    Assignee: General Electric Company
    Inventor: Mikko Kaski
  • Patent number: 10682508
    Abstract: An electrically stimulated CBD infused anesthetic patch system that is placed on a human's skin that is used to relieve pain. The electrically stimulated CBD infused anesthetic patch system comprises of a transdermal patch that has electrodes that receive an electric current from a TENS device. The transdermal patch is impregnated with a solution that has at least one analgesic that is selected from the group consisting of Menthol, CBD, Lidocaine or Capsaicin. The solution shall also include inactive ingredients.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 16, 2020
    Inventors: Trevor Theriot, Quanqin Dai, Mark Julian, Joseph Horton, John Lasso
  • Patent number: 10596382
    Abstract: Systems and related methods for enhancing learning of a sound pattern or relating to a sound pattern are described. A sound output corresponding to the sound pattern is delivering to the subject, and a learning enhancing neural stimulus is delivered to a cranial nerve of the subject in association with the sound output. The neural stimulus may be, for example, a transcutaneous neural stimulus. In an aspect, the subject is prompted to mentally rehearse the sound pattern. Electrical control circuitry controls timing of delivery of sound outputs and neural stimuli. In some aspects, the system is implemented in connection with a personal computing device.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: March 24, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney
  • Patent number: 10596014
    Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: March 24, 2020
    Assignee: Washington University
    Inventors: Eric Claude Leuthardt, Kimberly Kreines, Nick Anderson
  • Patent number: 10586997
    Abstract: A redox flow battery is described herein that has a sodium-super-ionic-conductor NaSICON barrier disposed between an anolyte chamber of the battery and the catholyte chamber of the battery. The NaSICON barrier prevents crossover of solvents or active redox species between the anolyte chamber and the catholyte chamber, while permitting transport of sodium ions between the chambers. In exemplary embodiments, the anolyte chamber includes an anolyte solution that comprises a first active redox species dissolved in a first solvent, while the catholyte chamber includes a catholyte solution that comprises a second active redox species dissolved in a second solvent.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 10, 2020
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: David Ingersoll, Ganesan Nagasubramanian, Eric Allcorn
  • Patent number: 10583287
    Abstract: A method for aesthetic soft tissue treatment includes placing at least one applicator in contact with the patient's body. The applicator has at least one electrode. Electrotherapy and radio frequency therapy are provided to the soft tissue, optionally with overlay or sequentially. A handheld applicator may be used, with the applicator moving during the therapy, which may provide muscle stimulation in the patient, or provide an analgesic effect during the treatment. A spacing object may be positioned between the skin of the patient and the applicator.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 10, 2020
    Assignee: BTL MEDICAL TECHNOLOGIES S.R.O.
    Inventor: Tomás Schwarz