Combined With Nonelectrical Therapy Patents (Class 607/3)
  • Patent number: 10420496
    Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 24, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Bahar Reghabi, James L. Henke, Wayne A. Morgan, Gopikrishnan Soundararajan, David Y. Choy, Peter Schultz, Udo Hoss
  • Patent number: 10406056
    Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 10, 2019
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Grégoire Courtine, Silvestro Micera, Joachim Von Zitzewitz
  • Patent number: 10398664
    Abstract: The present invention relates to methods for treating microbial infections on the surfaces of an implant or other surfaces near an implant in a patient. In particular, the methods are useful for treating biofilm infections. The methods include the use of minimally invasive techniques, including the use of ultra sound for facilitating the detection of biofilm infections on the implant or other surface of a patient and destroying the infection by administering an anthocyanin or an anthocyanidin or metabolite thereof. In particular, the administration of protocatechuic acid (PCA) or 2,4,6 trihydroxybenzaldehyde (2,4,6 THBA) for the treatment of an infected implant or other surface of a patient is described herein.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: September 3, 2019
    Inventor: Lanny Leo Johnson
  • Patent number: 10357646
    Abstract: An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric field across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: July 23, 2019
    Assignee: Highland Instruments
    Inventors: Timothy Andrew Wagner, Uri Tzvi Eden
  • Patent number: 10352948
    Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: July 16, 2019
    Assignee: Impulse Dynamics NV
    Inventors: Benny Rousso, Yuval Mika, Shlomo Ben Haim, Hani N. Sabbah
  • Patent number: 10342445
    Abstract: A system and method of monitoring electrocardiogram (ECG) signals and detecting ischemic conditions. In particular, high-frequency components and low-frequency components are extracted from the monitored ECG signal. The high-frequency components are analyzed to detect reduced amplitude zones (RAZs), while the low-frequency components are utilized to detect premature ventricular contraction (PVC) beats. Potentially ischemic conditions are identified based on both RAZs and PVC beats detected.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: July 9, 2019
    Assignee: Medtronic Monitoring, Inc.
    Inventors: ShaileshKumar V. Musley, Maneesh Shrivastav, Stacie Vilendrer
  • Patent number: 10325387
    Abstract: A disclosed state display method includes: determining which of a first period and a second period is dominant in a designated period based on chronological measurement results of vital activities of a subject in the designated period, the first period being a period that has been determined that the subject is in a sleep state, the second period being a period that has been determined that the subject is in a non-sleep state; and changing configuration of a display screen that displays information related to states of the subject in the designated period according to a result of the determining.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: June 18, 2019
    Assignee: FUJITSU LIMITED
    Inventors: Takayuki Yamaji, Kiyoshi Kawano
  • Patent number: 10315030
    Abstract: Methods, devices and systems for improving pelvic floor dysfunction in a patient suffering therefrom by electrically modulating neural tissue in a minimally invasive fashion using an electrical microstimulator are provided. Methods include inserting an electrical microstimulator having a re-deployable fixation member through skin of a patient's leg and advancing the electrical microstimulator through the skin along tissue of a surgical pathway to an area of the patient's leg. A target implant site can be identified that is above deep fascia and below the skin and that is adjacent to a target nerve associated with pelvic floor function. The electrical microstimulator can be anchored to the target implant site via the re-deployable fixation member or re-positioned, if necessary. A therapy electrical signal can be delivered to the target nerve from the target implant site.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 11, 2019
    Assignee: VERESSA MEDICAL, INC.
    Inventors: Benjamin A. Tranchina, Tracy L. Cameron, Jeffrey Richard Held, Jeff Weisgarber, Michael S. Labbe, Maekele Gebrekidan, Mohsin Zafar, Eric Gustin Hassenpflug, Alexandru Campean, Robert K. Deckman, Steven E. Wilder
  • Patent number: 10286213
    Abstract: An apparatus (10) for applying stimulation therapy to a patient includes an implantable medical device (20) and a remote controller (50) for inductively powering the medical device and communicating with the medical device. The remote controller (50) includes a feedback portion (220) for helping to establish a communication link between the remote controller and the implantable medical device (20).
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 14, 2019
    Assignee: AUTONOMIC TECHNOLOGIES, INC.
    Inventors: Kellie Fletcher, Patrick Hard, Anthony V. Caparso, Karen Tsuei
  • Patent number: 10265529
    Abstract: This invention provides an apparatus for electrically stimulating a cell and a method for using the same. In particular, the apparatus of the invention comprises an array of electrodes and a controller for actuating individual electrodes.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: April 23, 2019
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Wolfgang Fink, Erich Schmid
  • Patent number: 10265525
    Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: April 23, 2019
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
  • Patent number: 10252048
    Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: April 9, 2019
    Assignee: Oculeve, Inc.
    Inventors: James Donald Loudin, Daniel N. Hamilton, Manfred Franke, Douglas Michael Ackermann
  • Patent number: 10251809
    Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: April 9, 2019
    Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1
    Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10188859
    Abstract: A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions includes a main unit having an accommodating space and a patch portion; a control means installed in the accommodating space and including a printed circuit board assembly with an operating component for controlling low-frequency pulses and a heating operation, an electrical connector installed at the front of the printed circuit board assembly for charging a battery and reading, writing and transmitting data; at least one heating means installed at the main unit and electrically coupled to the printed circuit board assembly for producing a heating effect; at least one low-frequency electrode layer disposed under the patch portion and electrically coupled to the printed circuit board assembly for transmitting low-frequency pulses; and a battery installed in the accommodating space and directly and electrically coupled to the printed circuit board assembly for supplying power to the patch therapeutical apparatu
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: January 29, 2019
    Assignee: HIVOX BIOTEK INC.
    Inventor: Wei Tuan
  • Patent number: 10105102
    Abstract: Provided is a body-implantable package for processing biosensed-data for wireless communication to an external device. The package includes a tube closed by a cover, therein, a chip with a strained layer affixed thereto to form a flexible laminar circuit. The cover is fitted over an open end of the tube after the laminated chip and strained layer are inserted therein. The chip is constructed of and rolled in one or more turns into a generally cylindrical shape. The strained layer is affixed to a surface of the chip automatically to cause the flexible laminar circuit to curl into a generally cylindrical shape to fit within the tube.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: October 23, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Mitsuo Umemoto, Yung-Cheol Kong, Woon-Bae Kim, Pyoung-Wan Kim, Kyong-Soon Cho
  • Patent number: 10092738
    Abstract: Methods and devices are provided for inhibiting nerves when activating brown adipose tissue (BAT). In general, a first nerve type (e.g., sympathetic nerves) innervating BAT can be activated while at least one other nerve type (e.g., parasympathetic nerves and/or sensory nerves) innervating BAT is being suppressed. A first neuromodulator (e.g., an electrical signal, a chemical, a light, cooling, etc.) can be applied to activate the first nerve type, and a second neuromodulator can be applied to inhibit the at least one other nerve type. In this way, parasympathetic nerves and/or sensory nerves innervating BAT can be inhibited when activating sympathetic nerves innervating BAT.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: October 9, 2018
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Tamara C. Baynham
  • Patent number: 10087407
    Abstract: Methods, devices and systems are disclosed for vibration induced tissue engineering. Apparatuses, devices, systems and methods are provided for engineering a tissue from stem cells using vibratory signals. A tissue engineering apparatus, device, or system can include a transmitter configured to transmit a signal to a receiver, a receiver configured to receive a signal from a transmitter, a holding structure configured to hold one or more mesenchymal stem cells (MSC), and a vibratory actuator in communication with the receiver and configured to generate a vibratory signal that is applied to the MSC.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: October 2, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Robert G. Dennis, John A. van Aalst
  • Patent number: 10076662
    Abstract: A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions includes a main unit having an accommodating space and a patch portion; a control means installed in the accommodating space and including a printed circuit board assembly with an operating component for controlling low-frequency pulses and a heating operation, an electrical connector installed at the front of the printed circuit board assembly for charging a battery and reading, writing and transmitting data; at least one heating means installed at the main unit and electrically coupled to the printed circuit board assembly for producing a heating effect; at least one low-frequency electrode layer disposed under the patch portion and electrically coupled to the printed circuit board assembly for transmitting low-frequency pulses; and a battery installed in the accommodating space and directly and electrically coupled to the printed circuit board assembly for supplying power to the patch therapeutical apparatu
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: September 18, 2018
    Assignee: HIVOX BIOTEK INC.
    Inventor: Wei Tuan
  • Patent number: 10065039
    Abstract: Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: September 4, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Rafael Carbunaru, Kelly H. McClure, Jordi Parramon
  • Patent number: 10052495
    Abstract: A method of treating cardiac arrhythmia in a heart, including (i) determining that cardiac tissue is viable but with reduced innervation; and (ii) ablating the tissue to reduce a prevalence of arrhythmia in said heart. Optionally, the determining comprises detecting portions of heart wall which lack electrical activity. Optionally, at least some tissue which is viable but lacks nervous control is ablated, for example, to reduce or avoid arrhythmia.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: August 21, 2018
    Assignee: Tylerton International Inc.
    Inventor: Shlomo Ben-Haim
  • Patent number: 10016599
    Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to deliver an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: July 10, 2018
    Inventors: Charles Lockwood, Edmund Funai, Ali R. Rezai
  • Patent number: 9980766
    Abstract: Methods for treating preventing or decreasing the likelihood of a human patient developing hypertension and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods for therapeutic renal neuromodulation that partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient. This reduction in sympathetic neural activity is expected to therapeutically treat one or more conditions associated with hypertension or prehypertension of the patient. Renal sympathetic nerve activity can be modulated, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use mechanically-induced, electro-magnetically-induced, and/or chemically-induced approaches to modulate the renal nerves.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: May 29, 2018
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Sandeep S. Brar, Minglei Liu, Manuela Negoita
  • Patent number: 9976978
    Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: May 22, 2018
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Wayne A. Morgan, David Y. Choy, James L. Henke, Bahar Reghabi, Gopikrishnan Soundararajan, Peter Schultz, Udo Hoss
  • Patent number: 9950175
    Abstract: An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: April 24, 2018
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Ramesh Wariar, Barun Maskara, Qi An, Pramodsingh Hirasingh Thakur, Julie A. Thompson
  • Patent number: 9925377
    Abstract: A transcutaneous electrical-stimulation system includes a transcutaneous control module including a processor. The transcutaneous control module provides electrical-stimulation signals to electrode sets electrically-coupled to the transcutaneous control module. A first electrode set is electrically-coupled to the transcutaneous control module and is placed along patient skin over a first stimulation location. The first electrode set generates a first effective electric field suitable for transcutaneous stimulation of patient tissue at the first stimulation location. A second electrode set is electrically-coupled to the transcutaneous control module and is placed along patient skin over a second stimulation location. The second electrode set generates a second effective electric field suitable for stimulating patient tissue at the second stimulation location.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: March 27, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael A. Moffitt, Stephen Carcieri
  • Patent number: 9885031
    Abstract: An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: February 6, 2018
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Vish Subramaniam, Joseph West, Emily Alkandry, Mohd Nasser, Dinesh Ahirwar, Ramesh Ganju, Travis Jones
  • Patent number: 9884186
    Abstract: The present invention is related to an apparatus for activating electrophysiological mechanism and the method for configuring the same, which are based on diagnostic codes comprising at least more than two codes selected from a group of code classified by hue contrast to temperature differences according to heat distribution of a body. As a prescription for the above diagnostic codes, the activation prescription codes comprising code streams are generated, and then signals corresponding to each code are sequentially extracted and outputted as stimuli, and then finally become to provide activation stimuli to a body. The apparatus according to the present invention measures the distribution of body temperature, sets potential difference within an isolated system according to the distribution, and thus forces vibrations or waves with accelerated motion to be delivered to a whole body.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: February 6, 2018
    Inventor: Byongwon Park
  • Patent number: 9878154
    Abstract: Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary urgency, urinary incontinence, interstitial cystitis (IC), urinary retention, and pelvic pain; gastrointestinal conditions, such as fecal incontinence, irritable bowel syndrome (IBS), and constipation; and sexual conditions, such as premature ejaculation, erectile disorder, and female sexual arousal disorder by non-invasive transcutaneous electrical stimulation of the foot.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: January 30, 2018
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventor: Changfeng Tai
  • Patent number: 9867988
    Abstract: This invention provides an apparatus for electrically stimulating a cell and a method for using the same. In particular, the apparatus of the invention comprises an array of electrodes and a controller for actuating individual electrodes.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: January 16, 2018
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Wolfgang Fink, Erich Schmid
  • Patent number: 9849025
    Abstract: A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.
    Type: Grant
    Filed: September 7, 2013
    Date of Patent: December 26, 2017
    Assignees: YALE UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE, ITN ENERGY SYSTEMS, INC
    Inventors: Hitten P Zaveri, Dennis D Spencer, Bharat Joshi, David M Binkley, Bruce Lanning, Mohan S Misra
  • Patent number: 9829663
    Abstract: Technologies pertaining to a chip with a refractive index gradient, including fabrication thereof, are generally described. The refractive index gradient may be formed by creating atomic scale inclusions throughout a thickness of the chip by inducing nanoporosity into the chip, dissociating and diffusing oxygen into the chip, or performing chemical vapor deposition. One or more integrated circuit (IC) components and optical transceiver devices may be provided by mounting, growing, or etching the IC components and optical transceiver devices at a surface of the chip. The optical transceiver devices may be configured to transmit and/or receive an optical communication signal to and/or from at least one IC component or other optical transceiver device via an optical communication path within the thickness of the chip. The optical communication path may include a direction and distance, within the thickness of the chip, based on the refractive index gradient and angle of incidence.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: November 28, 2017
    Assignee: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventor: Benjamin William Millar
  • Patent number: 9821162
    Abstract: In some examples, a medical device delivers electrical stimulation to the external portion of the globus pallidus of a brain of a patient in order to treat a sleep impairment of the patient. In some examples, the electrical stimulation may be delivered via one or more electrodes implanted in the GPe of the brain. In some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of a sleep state of a patient. The sleep state may include, for example, a state in which the patient is awake and intending on sleeping, is awake and attempting to sleep or has initiated sleep. In addition, in some examples, an electrical stimulation device is configured to deliver electrical stimulation therapy to the GPe based on detection of an awake state of a patient.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 21, 2017
    Assignee: Medtronic, Inc.
    Inventors: Jianping Wu, Rahul Gupta, Dwight E. Nelson
  • Patent number: 9821157
    Abstract: A system and method to treat neural communication impairment is provided. The neural communication impairment is present in a neural pathway, which can be a cortico-neuromuscular pathway, an intra-brain neural pathway, or in a sensory-cortico pathway. A synchronized external stimulation is applied to a first point in proximity to a first neural component at one end of the neural pathway and to a second point in proximity to a second neural component at the other end of the neural pathway. Two induced neural handshake signals contemporaneously arrive at a neural communication impairment point in the neural pathway, triggering and stimulating a rehabilitation process by which the neural connection is permanently improved. The synchronized applied electrical signals applied to the first and second points may have an opposite polarity in dipolar neural stimulation, or may have identical polarity and waveform in in-phase neural stimulation.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: November 21, 2017
    Assignee: The Research Foundation of the City University of New York
    Inventors: Zaghloul Ahmed, Andrzej Wieraszko
  • Patent number: 9814857
    Abstract: Apparatus for administering certain nerve blocks includes a sheath constructed from a flexible ultrasound echogenic material, a more rigid introducer/dilator for introducing the sheath into the patient, and an ultrasound echogenic catheter for inserting through the sheath once the distal end of the sheath is in place adjacent the nerve(s) to be blocked and the introducer/dilator has been withdrawn. The catheter has provisions at its proximal end for connecting to a source of local anesthetic. Methods for use of this apparatus are also described.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: November 14, 2017
    Assignee: Avent, Inc.
    Inventor: Michael F. Guzman
  • Patent number: 9808631
    Abstract: Systems and methods for communicating between medical devices. In one example, an implantable medical device comprising may comprise one or more electrodes and a controller coupled to the electrodes. The controller may be configured to receive a first communication pulse at a first communication pulse time and a second communication pulse at a second communication pulse time via the one or more electrodes. The controller may further be configured to identify one of three or more symbols based at least in part on the time difference between the first communication pulse time and the second communication pulse time.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: November 7, 2017
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Keith R. Maile, Michael J. Kane, Paul Huelskamp, Lance E. Juffer, Jeffrey E. Stahmann
  • Patent number: 9809810
    Abstract: An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: November 7, 2017
    Assignee: Ohio State Innovation Foundation
    Inventors: Vish Subramaniam, Joseph West, Emily Alkandry, Mohd Nasser, Dinesh Ahirwar, Ramesh Ganju
  • Patent number: 9795784
    Abstract: Systems and methods for treating a patient with dyspnea are disclosed. A method in accordance with a particular embodiment includes identifying the patient as suffering from dyspnea, and, based at least in part on identifying the patient as suffering from dyspnea, implanting an electrical signal delivery element within the patient in signal communication with an afferent neural pathway of a carotid body chemoreceptor. The method can further include at least reducing dyspneic sensations in the patient by directing an electrical signal from the electrical signal delivery element to the neural pathway to at least partially block afferent signals from the chemoreceptor.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: October 24, 2017
    Assignee: Cibiem, Inc.
    Inventors: Edwin J. Hlavka, Lynn S. Elliott
  • Patent number: 9782592
    Abstract: A neurostimulation system and method of blocking a neural axon. Time-varying electrical energy is conveyed to a blocking site on the neural axon for an initial phase. The conveyed electrical energy has an amplitude and frequency during the initial phase sufficient to block action potentials from propagating along the neural axon from a location proximal to the blocking site to a location distal to the blocking site. The time-varying electrical energy is conveyed to the blocking site on the neural axon for a subsequent phase contiguous with the initial phase. The conveyed electrical energy has a decreased amplitude and a frequency during the subsequent phase sufficient to maintain blocking of the action potentials along the neural axon from the location proximal to the blocking site to the location distal to the blocking site.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: October 10, 2017
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Dongchul Lee
  • Patent number: 9770204
    Abstract: Delivery of electrical stimulation to the substantia nigra and the subthalamic nucleus of a brain of a patient are independently controlled in order to treat sleep and movement disorders. Electrical stimulation of the subthalamic nucleus may be effective in treating symptoms associated with a movement disorder, and electrical stimulation of the substantia nigra may be effective in treating symptoms associated with a sleep disorder. During a sleep state of the patient, a sleep stage of the patient may be determined, and an electrical stimulation device may be controlled based on the determined sleep stage. Electrical stimulation of the substantia nigra and subthalamic nucleus may be delivered at substantially the same time or at different times.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: September 26, 2017
    Assignee: Medtronic, Inc.
    Inventors: Jianping Wu, Dwight E. Nelson, Xin Su, Gregory F. Molnar
  • Patent number: 9744365
    Abstract: This disclosure is related to techniques for presenting therapy factors related to medical device therapy in a manner that allows a user, such as a patient or a clinician, to receive, comprehend and evaluate information relating to therapy delivered by the medical device efficiently. In one aspect, a method comprises obtaining a data set corresponding to a therapy factor associated with delivery of a medical therapy to a patient with a medical system including an implantable medical device, receiving a user selection associated with a subset of the data set, the subset of the data set including less than all the information relating to the therapy factor in the data set, and presenting a representation, corresponding to the subset of the data set, of the therapy factor on a display of a programmer.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: August 29, 2017
    Assignee: Medtronic, Inc.
    Inventors: Jon P. Davis, Steven M. Goetz, James Zimmerman, Lynn A. Davenport, Rajeev M. Sahasrabudhe, David Simons
  • Patent number: 9662525
    Abstract: Provided are an upper limb rehabilitation robot including: a sensing member that is mounted and fixed to an upper limb of a user and captures motion of the upper limb according to a movement intention of the user; a motion control unit that is electrically connected to the sensing member, calculates a movement direction, a distance or angle, a speed, and an auxiliary force (target value) needed for the upper limb to move, intended by the upper limb, based on the motion captured by using the sensing member, and generates and outputs a control signal according to the calculated movement direction, distance or angle, speed, and auxiliary force (target value); and a multi-joint robot, to an end of an arm of which the sensing member is coupled, wherein the multi-joint robot guides movement of the upper limb fixed to the sensing member to selectively move or rotate toward a food tray placed at a designated position of a table along an X-axis, a Y-axis, or a Z-axis and provides an assistance force to the upper limb.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: May 30, 2017
    Assignee: Daegu Gyeongbuk Institute of Science and Technology
    Inventors: Seung Yeol Lee, Tae Hun Kang, Dong Bin Shin, Dae Jin Kim, Sung Hoon Eom, Jeon II Moon
  • Patent number: 9656055
    Abstract: This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 0.01 nanoseconds at the full-width-at-half-maximum. This treatment may at least prevent growth of the lesion.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: May 23, 2017
    Assignee: PULSE BIOSCIENCES, INC.
    Inventors: Jack Robert Weissberg, Gary Steven Lazar, Dong Yin
  • Patent number: 9648880
    Abstract: Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: May 16, 2017
    Assignees: University of Massachusetts, Worcester Polytechnic Institute
    Inventors: Paul Kaufman, Jessica Lopes Da Rosa-Spiegler, Reeta Prusty Rao, Ahmed Fazly
  • Patent number: 9649504
    Abstract: A light-based therapy device is provided that includes a controller mechanism that produces power and control signals to enable operation of one or more medical devices. An implantable light delivery device (IM-LDD) is coupled to the controller mechanism that receives the power and the control signals to enable a light source to emit sufficient illumination. The light source is implanted within body cavities enabling energy at one or more wavelengths to reach and provide therapy treatment to a selected region.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: May 16, 2017
    Assignee: ROGERS SCIENCES, INC.
    Inventors: Gary S. Rogers, Samuel L. Hill
  • Patent number: 9623264
    Abstract: The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: April 18, 2017
    Assignee: Highland Instruments
    Inventor: Timothy Andrew Wagner
  • Patent number: 9616237
    Abstract: Method and systems for determining the location or identify of implantable devices are disclosed. An implantable device generates an electrical output and then modifies the output at a pre-configured interval for a pre-configured period. A sensor detects the modified output and locates or identifies the implantable device based on the modified output.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: April 11, 2017
    Assignee: EBR SYSTEMS, INC.
    Inventors: Mike Pare, David Moore, N. Parker Willis
  • Patent number: 9610071
    Abstract: A surgical access system including a tissue distraction assembly and a tissue refraction assembly, both of which may be equipped with one or more electrodes for use in detecting the existence of (and optionally the distance and/or direction to) neural structures before, during, and after the establishment of an operative corridor to a surgical target site.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: April 4, 2017
    Assignee: NuVasive, Inc.
    Inventors: Patrick Miles, Scot Martinelli, Eric Finley
  • Patent number: 9609670
    Abstract: A system and method for providing wireless communications between a medical controller hub and an implant node are disclosed. The hub transmits signals to facilitate communication connections with the node. The signals include connection invitation polls with identification parameters. A node monitors the hub's transmissions for the connection invitation polls. When a poll is detected, the node compares the identification parameters to a list of preferred identification values. If the received identification parameter is on the preferred list, and the node and hub are not already connected, then the node responds to the connection invitation poll. If the received identification parameter is not on the preferred list, then the node continues to monitor hub transmissions for other connection invitation polls that include identification parameters that are on the preferred list.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: March 28, 2017
    Assignee: TEXAS INSTRUMENTS INCORPORATED
    Inventors: Jin-Meng Ho, June Chul Roh
  • Patent number: 9603558
    Abstract: Methods and devices for the diagnosis and treatment of diabetes are disclosed in which an analyte concentration within a peritoneal fluid of a human subject may be determined by implanting an analyte sensor apparatus in the subject where the apparatus may comprise a housing and a flexible sensing catheter which has a lumen with a plurality of apertures and an exterior surface with an analyte sensor affixed thereto. The catheter may comprise a proximal end attached to the housing and the remaining end may be positioned freely within the peritoneal space to contact peritoneal fluid where an analyte concentration in the peritoneal fluid may be sensed. The housing may be anchored at a subcutaneous site proximate the peritoneal space. The sensed analyte concentration may then be transduced into a transmittable electrical signal.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: March 28, 2017
    Assignee: TheraNova, LLC
    Inventors: Daniel R. Burnett, Evan S. Luxon, Marcie Hamilton, Brian M. Neil, Brett D. Mensh
  • Patent number: 9592398
    Abstract: Techniques for delivering genetic material to a target tissue site of a patient via a leadless implantable medical device that includes a pump and a stimulation energy delivery element are described. In some examples, delivery of genetic material to the target tissue site causes transgene expression of tissue at the target tissue site, which may result in generation of new cells or modified properties of existing cells of the target tissue site, facilitating more effective and efficient treatment of a disorder of the patient.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: March 14, 2017
    Assignee: Medtronic, Inc.
    Inventor: John G. Keimel