Combined With Nonelectrical Therapy Patents (Class 607/3)
  • Patent number: 10806927
    Abstract: This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: October 20, 2020
    Assignee: The Regents of the University of California
    Inventors: V. Reggie Edgerton, Yury Gerasimenko, Roland R. Roy, Daniel C. Lu
  • Patent number: 10799708
    Abstract: Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: October 13, 2020
    Assignee: NeuroSteer Ltd.
    Inventor: Nathan Intrator
  • Patent number: 10799695
    Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 13, 2020
    Assignee: Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Janusz Kuzma
  • Patent number: 10786676
    Abstract: Described here is a deep brain stimulation (“DBS”) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 29, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Gregory Frederick Molnar, Luke Johnson, David Escobar Sanabria, Edward Mark Bello, II, Jerrold L. Vitek, Matthew D. Johnson
  • Patent number: 10786610
    Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: September 29, 2020
    Assignee: TC1 LLC
    Inventor: Zijing Zeng
  • Patent number: 10772561
    Abstract: Various embodiments relate generally to electrical and electronic hardware, computer software and systems, and wired and wireless network communications to provide an interface between an organism and other computing machine-based entities, and, more specifically, to sensors that facilitate determination of a state of neural activity with which to associate data representing, for example, an intent and/or a command; to implementations of sensors under control to, for example, modify sensing characteristics to interpolate response signals spatially or temporally, or both, to facilitate determination of a state of neural activity; to the formation or implementation of a data model that includes, for example, data arrangements representative of at least neuronal activity to facilitate determination of a state of neural activity; and to mobile human-machine interface to facilitate control based on neuronal activity of an organism.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: September 15, 2020
    Inventor: Thomas Alan Donaldson
  • Patent number: 10758739
    Abstract: Brain dysfunction can be treated by restructuring neural pathways in the brain. A desired area in the brain to form a new neural pathway is selected. The area receives a sequential combination of (1) transcranial photobiomodulation therapy (PBMT) including a series of pulses having a frequency matched to a target brain wave and (2) another transcranial stimulation (e.g., transcranial direct current electrical stimulation and/or transcranial magnetic stimulation). The different stimulation mechanisms ensure that neuroplasticity occurs to restructure a neural pathway that is dysfunctional in nature to a new neural pathway that conducts normally.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: September 1, 2020
    Assignee: MULTI RADIANCE MEDICAL
    Inventors: Douglas Johnson, Max Kanarsky
  • Patent number: 10729350
    Abstract: A patient monitoring system for monitoring cardiac arrhythmias includes an ECG monitor configured to monitor cardiac potentials during cardiac cycles and an arterial blood flow monitor configured to monitor arterial blood flow and generate pulse waveform. The system further includes an arrhythmia detection module that detects the presence of an arrhythmia based on the cardiac potentials and generates an arrhythmia indicator, and an arrhythmia analysis module that assesses the severity of the detected arrhythmia. The arrhythmia analysis module calculates average sinus pulse information based on the pulse waveform data for two or more cardiac cycles occurring when no arrhythmia is detected, and then calculates average arrhythmia pulse information based on pulse waveform data for two or more cardiac cycles occurring after detection of the arrhythmia.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 4, 2020
    Assignee: General Electric Company
    Inventor: Mikko Kaski
  • Patent number: 10682508
    Abstract: An electrically stimulated CBD infused anesthetic patch system that is placed on a human's skin that is used to relieve pain. The electrically stimulated CBD infused anesthetic patch system comprises of a transdermal patch that has electrodes that receive an electric current from a TENS device. The transdermal patch is impregnated with a solution that has at least one analgesic that is selected from the group consisting of Menthol, CBD, Lidocaine or Capsaicin. The solution shall also include inactive ingredients.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 16, 2020
    Inventors: Trevor Theriot, Quanqin Dai, Mark Julian, Joseph Horton, John Lasso
  • Patent number: 10596014
    Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: March 24, 2020
    Assignee: Washington University
    Inventors: Eric Claude Leuthardt, Kimberly Kreines, Nick Anderson
  • Patent number: 10596382
    Abstract: Systems and related methods for enhancing learning of a sound pattern or relating to a sound pattern are described. A sound output corresponding to the sound pattern is delivering to the subject, and a learning enhancing neural stimulus is delivered to a cranial nerve of the subject in association with the sound output. The neural stimulus may be, for example, a transcutaneous neural stimulus. In an aspect, the subject is prompted to mentally rehearse the sound pattern. Electrical control circuitry controls timing of delivery of sound outputs and neural stimuli. In some aspects, the system is implemented in connection with a personal computing device.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: March 24, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney
  • Patent number: 10586997
    Abstract: A redox flow battery is described herein that has a sodium-super-ionic-conductor NaSICON barrier disposed between an anolyte chamber of the battery and the catholyte chamber of the battery. The NaSICON barrier prevents crossover of solvents or active redox species between the anolyte chamber and the catholyte chamber, while permitting transport of sodium ions between the chambers. In exemplary embodiments, the anolyte chamber includes an anolyte solution that comprises a first active redox species dissolved in a first solvent, while the catholyte chamber includes a catholyte solution that comprises a second active redox species dissolved in a second solvent.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 10, 2020
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: David Ingersoll, Ganesan Nagasubramanian, Eric Allcorn
  • Patent number: 10583287
    Abstract: A method for aesthetic soft tissue treatment includes placing at least one applicator in contact with the patient's body. The applicator has at least one electrode. Electrotherapy and radio frequency therapy are provided to the soft tissue, optionally with overlay or sequentially. A handheld applicator may be used, with the applicator moving during the therapy, which may provide muscle stimulation in the patient, or provide an analgesic effect during the treatment. A spacing object may be positioned between the skin of the patient and the applicator.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 10, 2020
    Assignee: BTL MEDICAL TECHNOLOGIES S.R.O.
    Inventor: Tomás Schwarz
  • Patent number: 10568551
    Abstract: A hearing diagnosis device and a hearing diagnosis method are provided. The device includes a storage unit, an otoacoustic emission detecting module, and a hearing diagnosis management module. The storage unit stores a hearing diagnosis image sample database and a hearing information sample database. The otoacoustic emission detecting module is configured to perform an otoacoustic emission detecting operation by playing a test audio to an ear of a user to obtain a first hearing diagnosis image corresponding to the ear. The hearing diagnosis management module is configured to perform a hearing diagnosis operation according to the first hearing diagnosis image, a plurality of hearing diagnosis image samples of the hearing diagnosis image sample database, and a plurality of hearing information samples, respectively corresponding to the hearing diagnosis image samples, of the hearing information sample database, so as to determine first hearing information of the ear.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 25, 2020
    Assignee: National Tsing Hua University
    Inventors: Hau-Tieng Wu, Pa-Chun Wang, Yi-Wen Liu
  • Patent number: 10561461
    Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: February 18, 2020
    Assignee: Axon Therapies, Inc.
    Inventors: Dorin Panescu, Andrew Wu, Zoar Jacob Engelman, Mark Gelfand, Mark S. Leung, Howard Levin
  • Patent number: 10556121
    Abstract: Methods and apparatuses (including systems, devices, etc.) for the treatment of neurological disorders, and particularly multiple sclerosis (MS) by the application of electromagnetic fields (EMF), and in particular, pulsed electromagnetic fields (PEMF), including a subset of PEMF in a radio frequency domain (e.g., pulse-modulated radio frequency or PRF). This treatment may prevent or delay the onset, and/or may reduce the severity of the onset of MS and MS-related symptoms.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: February 11, 2020
    Assignee: Endonovo Therapeutics, Inc.
    Inventor: Blake Taylor Gurfein
  • Patent number: 10548578
    Abstract: A device for automatically registering the penetration depth of an invasive instrument into an opening and the rotational orientation of an invasive instrument in an opening of a body with the aid of a length-selective and rotation-selective pattern applied to the surface of the instrument, wherein the device has a sensor embodied to surround the instrument in a ring-shaped manner. According to the invention, the sensor is embodied for registering the length-selective and rotation-selective pattern and embodied and provided for the temporary arrangement in the region of the opening for the insertion of the invasive instrument. The device according to the invention has an evaluation unit for evaluating the penetration depth and the rotational orientation of an invasive instrument on the basis of the registered selective pattern.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: February 4, 2020
    Assignee: Karl Storz SE & Co. KG
    Inventor: Ulrich Gruhler
  • Patent number: 10537732
    Abstract: A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 21, 2020
    Assignee: FLOWAID MEDICAL TECHNOLOGIES CORP.
    Inventors: Zvi Nachum, Yaakov B. Brezel, Shalom Lampert
  • Patent number: 10532202
    Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: January 14, 2020
    Assignee: VOMARIS INNOVATIONS, INC.
    Inventors: Jeffry Skiba, Inder Raj S. Makin
  • Patent number: 10471257
    Abstract: Systems and methods of reducing pain after surgery in the thoracic or abdominal region and managing chronic nerve pain in the thoracic or abdominal region are provided. Such methods involve an electrode assembly that has a proximal portion and a distal portion with the distal portion including a plurality of electrodes. At least one electrode of the plurality of electrodes is placed over each of a plurality of intercostal nerve bundles in the patient's body. The proximal portion of the electrode assembly is connected to a pulse generator. An electromagnetic field is applied to the plurality of intercostal nerve bundles. The plurality of electrodes is removed from the patient's body after an intercostal nerve block sufficient to alleviate the patient's pain has been achieved.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 12, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Usman Ahmad, Sudish Murthy, Jonathan Sakai
  • Patent number: 10463299
    Abstract: System for determining the effectiveness of various prescribed medications. Here a variety of different types of patient pulse wave measurements (e.g. blood pressure, pulse oximeter, ECG) and other physiological measurements are obtained. This actual data is compared to calculated measurements that would be expected based on the various patient baseline measurements in the absence of medication, schedule of medications, and impact of medications the various patient baseline measurements. If the actual data meets expectations, then the medication is likely acting as anticipated. Depending on which types of data do not meet expectations, problems with one or more previously described medications may be reported. Other types of patient physiological readings, such as temperature, motion, lung function, brain wave function (EEG) and the like may also be obtained, and these additional types of readings can be used to extend the range of different types of drugs/medications that the system can successfully monitor.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: November 5, 2019
    Assignee: Cloud Dx, Inc.
    Inventors: Sandeep S. Kohli, David Widman, Robert Kaul, Sara Ross-Howe
  • Patent number: 10463531
    Abstract: A system is provided for stimulating a portion of skin, the system including at least two electrodes; a motor and an electrical system, the electrical system including a power source; and an end effector operably coupled to the motor and the electrical system, the end effector having at least one embedded electrode, from the at least two electrodes, disposed and operably coupled to the electrical system at which the end effector is configured to be in electrical communication with the portion of skin, wherein the motor is configured to subject the end effector to repetitive movements while contacting the skin to provide mechanical stimulation to the skin, wherein the at least one embedded electrode is configured to serve as a source electrode and another of the at least two electrodes is configured to serve as a return electrode, and wherein the power source is configured to bias the source electrode to the return electrode and form an electric field with the portion of skin.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: November 5, 2019
    Assignee: L'OREAL
    Inventors: Kaye Brunson, Lilac Muller, Zane Bowman Allen Miller, Vincenzo Casasanta, III
  • Patent number: 10450181
    Abstract: A system for achieving the sensation of drinking a particular drink, known as the target liquid, when in fact another drink, such as water, is being consumed. The system consists of a glass which contains not only water but also a small amount of the target liquid, in order to provide the true smell and image of the desired drink, as well as an electronic system for generating a series of signals which, by means of electrodes, stimulate the user's tongue to act on a series of nerve cells and provide the brain with a signal as similar as possible to that which the real drink provides to the taste buds of the user. The user of the system thus has the sensation of drinking the target liquid.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: October 22, 2019
    Inventor: Alberto Adarve Lozano
  • Patent number: 10441793
    Abstract: An implantable leadless pacemaker (iLP) for a human or animal heart, wherein the iLP includes a housing, at least two electrode poles for picking up electrical potentials and/or delivering electrical stimulation, a stimulation control unit in connection with the electrode poles, a sensing unit that is in connection with at least one electrode pole, a signal processing unit in connection with the sensing unit, a signal evaluation unit in connection with the signal processing unit and/or the sensing unit, and an energy source. The sensing unit is configured to sense a first signal associated with an activity of the first heart chamber, and the stimulation control unit is configured to deliver electrical stimulation in the first heart chamber via the at least two electrode poles. wherein the sensing unit is configured to sense a second signal associated with an activity of a second heart chamber.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: October 15, 2019
    Assignee: Biotronik SE & Co. KG
    Inventors: Dirk Muessig, Andrew B. Kibler, Larry Stotts
  • Patent number: 10420496
    Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 24, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Bahar Reghabi, James L. Henke, Wayne A. Morgan, Gopikrishnan Soundararajan, David Y. Choy, Peter Schultz, Udo Hoss
  • Patent number: 10406056
    Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 10, 2019
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Grégoire Courtine, Silvestro Micera, Joachim Von Zitzewitz
  • Patent number: 10398664
    Abstract: The present invention relates to methods for treating microbial infections on the surfaces of an implant or other surfaces near an implant in a patient. In particular, the methods are useful for treating biofilm infections. The methods include the use of minimally invasive techniques, including the use of ultra sound for facilitating the detection of biofilm infections on the implant or other surface of a patient and destroying the infection by administering an anthocyanin or an anthocyanidin or metabolite thereof. In particular, the administration of protocatechuic acid (PCA) or 2,4,6 trihydroxybenzaldehyde (2,4,6 THBA) for the treatment of an infected implant or other surface of a patient is described herein.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: September 3, 2019
    Inventor: Lanny Leo Johnson
  • Patent number: 10357646
    Abstract: An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric field across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: July 23, 2019
    Assignee: Highland Instruments
    Inventors: Timothy Andrew Wagner, Uri Tzvi Eden
  • Patent number: 10352948
    Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: July 16, 2019
    Assignee: Impulse Dynamics NV
    Inventors: Benny Rousso, Yuval Mika, Shlomo Ben Haim, Hani N. Sabbah
  • Patent number: 10342445
    Abstract: A system and method of monitoring electrocardiogram (ECG) signals and detecting ischemic conditions. In particular, high-frequency components and low-frequency components are extracted from the monitored ECG signal. The high-frequency components are analyzed to detect reduced amplitude zones (RAZs), while the low-frequency components are utilized to detect premature ventricular contraction (PVC) beats. Potentially ischemic conditions are identified based on both RAZs and PVC beats detected.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: July 9, 2019
    Assignee: Medtronic Monitoring, Inc.
    Inventors: ShaileshKumar V. Musley, Maneesh Shrivastav, Stacie Vilendrer
  • Patent number: 10325387
    Abstract: A disclosed state display method includes: determining which of a first period and a second period is dominant in a designated period based on chronological measurement results of vital activities of a subject in the designated period, the first period being a period that has been determined that the subject is in a sleep state, the second period being a period that has been determined that the subject is in a non-sleep state; and changing configuration of a display screen that displays information related to states of the subject in the designated period according to a result of the determining.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: June 18, 2019
    Assignee: FUJITSU LIMITED
    Inventors: Takayuki Yamaji, Kiyoshi Kawano
  • Patent number: 10315030
    Abstract: Methods, devices and systems for improving pelvic floor dysfunction in a patient suffering therefrom by electrically modulating neural tissue in a minimally invasive fashion using an electrical microstimulator are provided. Methods include inserting an electrical microstimulator having a re-deployable fixation member through skin of a patient's leg and advancing the electrical microstimulator through the skin along tissue of a surgical pathway to an area of the patient's leg. A target implant site can be identified that is above deep fascia and below the skin and that is adjacent to a target nerve associated with pelvic floor function. The electrical microstimulator can be anchored to the target implant site via the re-deployable fixation member or re-positioned, if necessary. A therapy electrical signal can be delivered to the target nerve from the target implant site.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 11, 2019
    Assignee: VERESSA MEDICAL, INC.
    Inventors: Benjamin A. Tranchina, Tracy L. Cameron, Jeffrey Richard Held, Jeff Weisgarber, Michael S. Labbe, Maekele Gebrekidan, Mohsin Zafar, Eric Gustin Hassenpflug, Alexandru Campean, Robert K. Deckman, Steven E. Wilder
  • Patent number: 10286213
    Abstract: An apparatus (10) for applying stimulation therapy to a patient includes an implantable medical device (20) and a remote controller (50) for inductively powering the medical device and communicating with the medical device. The remote controller (50) includes a feedback portion (220) for helping to establish a communication link between the remote controller and the implantable medical device (20).
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 14, 2019
    Assignee: AUTONOMIC TECHNOLOGIES, INC.
    Inventors: Kellie Fletcher, Patrick Hard, Anthony V. Caparso, Karen Tsuei
  • Patent number: 10265529
    Abstract: This invention provides an apparatus for electrically stimulating a cell and a method for using the same. In particular, the apparatus of the invention comprises an array of electrodes and a controller for actuating individual electrodes.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: April 23, 2019
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Wolfgang Fink, Erich Schmid
  • Patent number: 10265525
    Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: April 23, 2019
    Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
    Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
  • Patent number: 10252048
    Abstract: Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: April 9, 2019
    Assignee: Oculeve, Inc.
    Inventors: James Donald Loudin, Daniel N. Hamilton, Manfred Franke, Douglas Michael Ackermann
  • Patent number: 10251809
    Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: April 9, 2019
    Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1
    Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
  • Patent number: 10188859
    Abstract: A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions includes a main unit having an accommodating space and a patch portion; a control means installed in the accommodating space and including a printed circuit board assembly with an operating component for controlling low-frequency pulses and a heating operation, an electrical connector installed at the front of the printed circuit board assembly for charging a battery and reading, writing and transmitting data; at least one heating means installed at the main unit and electrically coupled to the printed circuit board assembly for producing a heating effect; at least one low-frequency electrode layer disposed under the patch portion and electrically coupled to the printed circuit board assembly for transmitting low-frequency pulses; and a battery installed in the accommodating space and directly and electrically coupled to the printed circuit board assembly for supplying power to the patch therapeutical apparatu
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: January 29, 2019
    Assignee: HIVOX BIOTEK INC.
    Inventor: Wei Tuan
  • Patent number: 10105102
    Abstract: Provided is a body-implantable package for processing biosensed-data for wireless communication to an external device. The package includes a tube closed by a cover, therein, a chip with a strained layer affixed thereto to form a flexible laminar circuit. The cover is fitted over an open end of the tube after the laminated chip and strained layer are inserted therein. The chip is constructed of and rolled in one or more turns into a generally cylindrical shape. The strained layer is affixed to a surface of the chip automatically to cause the flexible laminar circuit to curl into a generally cylindrical shape to fit within the tube.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: October 23, 2018
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Mitsuo Umemoto, Yung-Cheol Kong, Woon-Bae Kim, Pyoung-Wan Kim, Kyong-Soon Cho
  • Patent number: 10092738
    Abstract: Methods and devices are provided for inhibiting nerves when activating brown adipose tissue (BAT). In general, a first nerve type (e.g., sympathetic nerves) innervating BAT can be activated while at least one other nerve type (e.g., parasympathetic nerves and/or sensory nerves) innervating BAT is being suppressed. A first neuromodulator (e.g., an electrical signal, a chemical, a light, cooling, etc.) can be applied to activate the first nerve type, and a second neuromodulator can be applied to inhibit the at least one other nerve type. In this way, parasympathetic nerves and/or sensory nerves innervating BAT can be inhibited when activating sympathetic nerves innervating BAT.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: October 9, 2018
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Tamara C. Baynham
  • Patent number: 10087407
    Abstract: Methods, devices and systems are disclosed for vibration induced tissue engineering. Apparatuses, devices, systems and methods are provided for engineering a tissue from stem cells using vibratory signals. A tissue engineering apparatus, device, or system can include a transmitter configured to transmit a signal to a receiver, a receiver configured to receive a signal from a transmitter, a holding structure configured to hold one or more mesenchymal stem cells (MSC), and a vibratory actuator in communication with the receiver and configured to generate a vibratory signal that is applied to the MSC.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: October 2, 2018
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Robert G. Dennis, John A. van Aalst
  • Patent number: 10076662
    Abstract: A portable one-piece therapeutical apparatus with dual heating and low-frequency treatment functions includes a main unit having an accommodating space and a patch portion; a control means installed in the accommodating space and including a printed circuit board assembly with an operating component for controlling low-frequency pulses and a heating operation, an electrical connector installed at the front of the printed circuit board assembly for charging a battery and reading, writing and transmitting data; at least one heating means installed at the main unit and electrically coupled to the printed circuit board assembly for producing a heating effect; at least one low-frequency electrode layer disposed under the patch portion and electrically coupled to the printed circuit board assembly for transmitting low-frequency pulses; and a battery installed in the accommodating space and directly and electrically coupled to the printed circuit board assembly for supplying power to the patch therapeutical apparatu
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: September 18, 2018
    Assignee: HIVOX BIOTEK INC.
    Inventor: Wei Tuan
  • Patent number: 10065039
    Abstract: Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: September 4, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Rafael Carbunaru, Kelly H. McClure, Jordi Parramon
  • Patent number: 10052495
    Abstract: A method of treating cardiac arrhythmia in a heart, including (i) determining that cardiac tissue is viable but with reduced innervation; and (ii) ablating the tissue to reduce a prevalence of arrhythmia in said heart. Optionally, the determining comprises detecting portions of heart wall which lack electrical activity. Optionally, at least some tissue which is viable but lacks nervous control is ablated, for example, to reduce or avoid arrhythmia.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: August 21, 2018
    Assignee: Tylerton International Inc.
    Inventor: Shlomo Ben-Haim
  • Patent number: 10016599
    Abstract: One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. The housing can be configured for implantation in a reproductive system of the subject. The at least one electrode can be connected to the housing and be configured to deliver an electrical signal to an autonomic nervous system nerve target. The power source can be in electrical communication with the at least one electrode.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: July 10, 2018
    Inventors: Charles Lockwood, Edmund Funai, Ali R. Rezai
  • Patent number: 9980766
    Abstract: Methods for treating preventing or decreasing the likelihood of a human patient developing hypertension and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods for therapeutic renal neuromodulation that partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient. This reduction in sympathetic neural activity is expected to therapeutically treat one or more conditions associated with hypertension or prehypertension of the patient. Renal sympathetic nerve activity can be modulated, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use mechanically-induced, electro-magnetically-induced, and/or chemically-induced approaches to modulate the renal nerves.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: May 29, 2018
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Sandeep S. Brar, Minglei Liu, Manuela Negoita
  • Patent number: 9976978
    Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: May 22, 2018
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Wayne A. Morgan, David Y. Choy, James L. Henke, Bahar Reghabi, Gopikrishnan Soundararajan, Peter Schultz, Udo Hoss
  • Patent number: 9950175
    Abstract: An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: April 24, 2018
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Ramesh Wariar, Barun Maskara, Qi An, Pramodsingh Hirasingh Thakur, Julie A. Thompson
  • Patent number: 9925377
    Abstract: A transcutaneous electrical-stimulation system includes a transcutaneous control module including a processor. The transcutaneous control module provides electrical-stimulation signals to electrode sets electrically-coupled to the transcutaneous control module. A first electrode set is electrically-coupled to the transcutaneous control module and is placed along patient skin over a first stimulation location. The first electrode set generates a first effective electric field suitable for transcutaneous stimulation of patient tissue at the first stimulation location. A second electrode set is electrically-coupled to the transcutaneous control module and is placed along patient skin over a second stimulation location. The second electrode set generates a second effective electric field suitable for stimulating patient tissue at the second stimulation location.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: March 27, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Michael A. Moffitt, Stephen Carcieri
  • Patent number: 9885031
    Abstract: An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: February 6, 2018
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Vish Subramaniam, Joseph West, Emily Alkandry, Mohd Nasser, Dinesh Ahirwar, Ramesh Ganju, Travis Jones