Combined With Nonelectrical Therapy Patents (Class 607/3)
  • Patent number: 11154717
    Abstract: An indication that a patient event occurred may be used to evaluate the efficacy of at least one therapy program and/or adjust therapy delivery to the patient. In some examples, the patient event indication includes patient input that may be received via an event indication button of a programming device. In some examples, therapy delivery may be adjusted by adjusting at least one therapy parameter value, switching therapy programs or therapy program groups or restarting a therapy cycle of a medical device.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: October 26, 2021
    Assignee: Medtronic, Inc.
    Inventors: Jonathon E. Giftakis, Peter J. Kovach, Warren W. Ball, Jonathan C. Werder, Nina M. Graves, David C. Ullestad, Sarah B. Alme
  • Patent number: 11141219
    Abstract: A method of treating tissue of a patient uses a device including a mother case, a belt, at least one treatment unit and at least two applicators. The treatment method may include attaching first and second applicators to the belt at a working distance to the patient's surface, and providing different treatment energy to the first applicator and the second applicator. A treatment pattern is created by the applicators providing the different treatment energies. The hardware pattern or positions of the applicators on the belt may be changed before and/or during the treatment. The hardware pattern may be based on selected treatment effect and body part.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: October 12, 2021
    Assignee: BTL Healthcare Technologies, a.s.
    Inventor: Tomás̆ Schwarz
  • Patent number: 11116962
    Abstract: A method of a soft tissue treatment comprises placing an applicator adjacent to a surface of a body part, the applicator including at least one electrode, providing a fastening mechanism fixing the applicator in contact with the body part, providing a radiofrequency energy by the at least one electrode causing a heating of the soft tissue, providing an electric current to the soft tissue by the at least one electrode causing a muscle contraction, and controlling heating of the soft tissue by the radiofrequency energy and parameters of the electric current provided by the at least one electrode via a control unit, wherein an energy flux density of the radiofrequency energy is in a range of 0.01 mW·mm?2 to 10 W·mm?2 and a frequency of the radiofrequency energy is in a range of 0.1 MHz to 25 GHz, and wherein the body part comprises a face or a chin.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: September 14, 2021
    Assignee: BTL Healthcare Technologies a.s.
    Inventors: Ondrej Prouza, Tomá{hacek over (s)} Schwarz
  • Patent number: 11089998
    Abstract: A device and method for increasing a patient's compliance with a therapy relating to an upper airway disorder includes a receiving unit, a processing unit, and a display unit. The receiving unit is configured to receive vital sign data including glucose level data of the patient, and therapy data including information regarding the therapy of the patient. The processing unit is configured to process the therapy data and the vital sign data in order to determine feedback information based on the therapy data and the vital sign data. Lastly, the display unit is configured to display the feedback information based on the therapy data and the vital sign data.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: August 17, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Mareike Klee, Jacob Roger Haartsen, Mark Steven Aloia, Richard Andrew Sofranko, David Smith
  • Patent number: 11071860
    Abstract: Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: July 27, 2021
    Assignee: ONCOSEC MEDICAL INCORPORATED
    Inventors: John Rodriguez, Jason Jin, Brandon Dang Phung, Wesley Joel Ericson, Jodie Marie Houdek, Jonathan Joseph McIntosh, Carlos E. Gonzalez, Anthony Steven Nault
  • Patent number: 11065448
    Abstract: Devices and methods to deliver microcurrent stimulation therapy to the human body, when connected to a micro-stimulation current-generating apparatus. The method of applying microcurrent stimulation therapy to key points around the eye for treatment of problems such as macular degeneration, retinitis pigmentosa, glaucoma, optic neuritis and other eye-related or nerve-related conditions, as well as other diseases, such as Bell's Palsy, requiring localized stimulation to the eyes and/or on other body parts.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: July 20, 2021
    Assignee: i-Lumen Scientific, Inc.
    Inventors: Blair P. Mowery, Marshall T. Masko, John B. Jarding, Gary A. Tapp
  • Patent number: 11045130
    Abstract: The present disclosure relates to measuring biosignals (particularly, electroencephalogram) of fish in a non-invasive and multi-channels manner, with a multi-channel electrode array of one or more conductive plates non-invasively attached to the epidermis of the fish outside of the water a; a reference electrode non-invasively attached to the epidermis of the fish outside of the surface of the water; a supply device that supplies a predetermined material and oxygen to the fish outside of the water; and a minute tube inserted into the oral cavity of the fish outside of the water to resuscitate the fish in a stable state to generate normal electroencephalogram.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 29, 2021
    Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE & TECHNOLOGY
    Inventor: So Hee Kim
  • Patent number: 11037260
    Abstract: A system includes a processor coupled to a memory. The processor and memory are configured to, during an emergency situation, initiate presentation, on a user interface, of information indicative of a location of one or more shelters. The processor and memory are configured to, during the emergency situation, receive, from a server, data indicative of actual occupancy of at least one of the one or more shelters. The processor and memory are configured to enable a rescuer to access information, through the user interface, about one or more of a potential occupancy and the actual occupancy of the at least one of the one or more shelters.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: June 15, 2021
    Assignee: ZOLL Medical Corporation
    Inventor: Guy R. Johnson
  • Patent number: 11027092
    Abstract: A device for replicating a natural magnetic vibration of Earth, promoting more restful sleep. The device produces an appropriately uniform magnetic field across the surface of the area where the head rests during sleep. The device provides a varying magnetic field therapy that allows a user to sleep in their usual manner using their existing familiar pillow, with no changes to the aesthetics of the bed, while using the device having varying magnetic field therapy capabilities.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: June 8, 2021
    Inventor: Paul M. Bode
  • Patent number: 11020051
    Abstract: Methods of enhancing homeostatic capacity in a subject are provided. Aspects of the methods include modulating synchrony, e.g., via modulating communication and/or coordination, among two or more distinct homeostatic systems of the subject in a manner sufficient to enhance homeostatic capacity of the subject. Also provided are devices configured for use in practicing the methods. Aspects of the invention further include methods of treating a subject for a condition via enhancement of homeostatic capacity. The methods and devices described herein find use in a variety of applications.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: June 1, 2021
    Assignee: Palo Alto Investors
    Inventors: Anthony Joonkyoo Yun, Conrad Minkyoo Yun
  • Patent number: 10960210
    Abstract: An Example of a system for providing a patient with pain management may include a sleep monitoring circuit, a pain relief device, and a control circuit. The sleep monitoring circuit may be configured to sense one or more sleep signals from the patient and to determine a sleep state of the patient using the one or more sleep signals. The one or more sleep signals may include one or more physiological signals corresponding to the sleep state of the patient. The pain relief device may be configured to deliver one or more pain relief therapies. The control circuit may be configured to control the delivery of the one or more pain relief therapies using therapy parameters and to adjust the therapy parameters based on the determined sleep state.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 30, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Kyle Harish Srivastava, Bryan Allen Clark, Elizabeth Mary Annoni, Jianwen Gu
  • Patent number: 10960201
    Abstract: Methods and devices are provided for inhibiting nerves when activating brown adipose tissue (BAT). In general, a first nerve type (e.g., sympathetic nerves) innervating BAT can be activated while at least one other nerve type (e.g., parasympathetic nerves and/or sensory nerves) innervating BAT is being suppressed. A first neuromodulator (e.g., an electrical signal, a chemical, a light, cooling, etc.) can be applied to activate the first nerve type, and a second neuromodulator can be applied to inhibit the at least one other nerve type. In this way, parasympathetic nerves and/or sensory nerves innervating BAT can be inhibited when activating sympathetic nerves innervating BAT.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: March 30, 2021
    Assignee: Ethicon LLC
    Inventors: Jason L. Harris, Tamara C. Baynham
  • Patent number: 10952666
    Abstract: Treatment controllers and methods are provided that can be integrated with treatment systems, such as peritoneal dialysis systems, hemodialysis systems, and nocturnal treatment systems, to manage execution of treatment operations or a course of treatment based on timing information and/or patient sleep state.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 23, 2021
    Assignee: FRESENIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Daniel Schmidt, Bert D. Egley
  • Patent number: 10918880
    Abstract: A method and apparatus for treatment of chronic kidney disease (CKD), particular diabetic nephropathy, are disclosed. The method comprises activation of adenosine A2a receptors in parenchymal and immune cells infiltrated into kidneys. The activation is performed by PEMF (pulsed electromagnetic field) stimulation applied locally to kidneys. Adenosine A2a signaling pathway is a potent anti-inflammatory and immuno-suppressive regulator that has been proven to attenuate inflammation and injury in diabetic nephropathy. Efficient activation of A2a receptors is achieved by applying electromagnetic field stimulation consecutively in 3 spatial dimensions. This allows attaining a significant increase in activation of A2a receptors in comparison with one-dimensional stimulation. Assistant thermal stimulation may be applied to increase expression of heat shock proteins (HSPs) in parenchymal cells.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: February 16, 2021
    Assignee: Minnesota Medical Physics LLC
    Inventors: Victor Ivan Chornenky, Ali Jaafar
  • Patent number: 10893805
    Abstract: For characterizing spatial-temporal dynamics of a medium (1) excitable for deformation, an elastic model of the medium is defined. The medium is imaged at consecutive points in time to obtain a series of images. Shifts of structures of the medium (1) between the images of the series are determined. A dynamic description of a temporal development of spatial deformations of a predefined elastic model of the medium (1) is adapted to match the shifts of the structures; and temporal developments of rate of deformation patterns in the medium (1) are identified from the dynamic description.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 19, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Stefan Luther, Jan Christoph
  • Patent number: 10870006
    Abstract: An apparatus for applying at least one electric pulse to a living myocardial tissue comprises an input configured to receive an electric signal representing a present electric activity of the myocardial tissue; a signal processor configured to process the electric signal to calculate a present permutation value of the electric signal in the state space and to only output a control signal when the calculated present entropy value of the electric signal is lower than a predetermined entropy threshold value; a pulse generator configured to generate the at least one electric pulse in response to the control signal; and an output configured to output the at least one electric pulse to the myocardial tissue.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 22, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Alexander Schlemmer, Thomas Lilienkamp, Sebastian Berg, Ulrich Parlitz, Stefan Luther
  • Patent number: 10857355
    Abstract: A direct current delivery device includes a direct current source or a device for connecting to a direct current source, and a first electrode and a second electrode for connecting to the direct current source, wherein the first electrode is configured as a plurality of needles and the second electrode is configured as a planar electrode, as a needle or a plurality of needles directly connected to one another in an electrically conductive manner. The direct current delivery device includes one or more devices configured to maintain the current intensity constant during the individual delivery of direct current through the needles of the first electrode.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 8, 2020
    Inventor: Albrecht Molsberger
  • Patent number: 10806927
    Abstract: This disclosure provides non-invasive methods to induce motor control in a mammal subject to spinal cord or other neurological injuries. In certain embodiments the method involves administering transcutaneous electrical spinal cord stimulation (tSCS) to the mammal at a frequency and intensity that induces the desired locomotor activity.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: October 20, 2020
    Assignee: The Regents of the University of California
    Inventors: V. Reggie Edgerton, Yury Gerasimenko, Roland R. Roy, Daniel C. Lu
  • Patent number: 10799708
    Abstract: Methods and systems for optimizing invasive and noninvasive brain stimulation are described herein. In a particular embodiment, methods and systems for a combinatorial, iterative approach to modify behavior are presented wherein deep brain stimulation (DBS) and other brain stimulation therapies are implemented in combination with monitoring the brain activity of an individual to optimize the effectiveness of the combinatorial approach to modify behavior. Methods described herein are iterative and systems described herein are utilized in iterative fashion. In a particular embodiment, modifying behavior provides a therapy for an individual in need thereof.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: October 13, 2020
    Assignee: NeuroSteer Ltd.
    Inventor: Nathan Intrator
  • Patent number: 10799695
    Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 13, 2020
    Assignee: Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Janusz Kuzma
  • Patent number: 10786610
    Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: September 29, 2020
    Assignee: TC1 LLC
    Inventor: Zijing Zeng
  • Patent number: 10786676
    Abstract: Described here is a deep brain stimulation (“DBS”) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 29, 2020
    Assignee: Regents of the University of Minnesota
    Inventors: Gregory Frederick Molnar, Luke Johnson, David Escobar Sanabria, Edward Mark Bello, II, Jerrold L. Vitek, Matthew D. Johnson
  • Patent number: 10772561
    Abstract: Various embodiments relate generally to electrical and electronic hardware, computer software and systems, and wired and wireless network communications to provide an interface between an organism and other computing machine-based entities, and, more specifically, to sensors that facilitate determination of a state of neural activity with which to associate data representing, for example, an intent and/or a command; to implementations of sensors under control to, for example, modify sensing characteristics to interpolate response signals spatially or temporally, or both, to facilitate determination of a state of neural activity; to the formation or implementation of a data model that includes, for example, data arrangements representative of at least neuronal activity to facilitate determination of a state of neural activity; and to mobile human-machine interface to facilitate control based on neuronal activity of an organism.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: September 15, 2020
    Inventor: Thomas Alan Donaldson
  • Patent number: 10758739
    Abstract: Brain dysfunction can be treated by restructuring neural pathways in the brain. A desired area in the brain to form a new neural pathway is selected. The area receives a sequential combination of (1) transcranial photobiomodulation therapy (PBMT) including a series of pulses having a frequency matched to a target brain wave and (2) another transcranial stimulation (e.g., transcranial direct current electrical stimulation and/or transcranial magnetic stimulation). The different stimulation mechanisms ensure that neuroplasticity occurs to restructure a neural pathway that is dysfunctional in nature to a new neural pathway that conducts normally.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: September 1, 2020
    Assignee: MULTI RADIANCE MEDICAL
    Inventors: Douglas Johnson, Max Kanarsky
  • Patent number: 10729350
    Abstract: A patient monitoring system for monitoring cardiac arrhythmias includes an ECG monitor configured to monitor cardiac potentials during cardiac cycles and an arterial blood flow monitor configured to monitor arterial blood flow and generate pulse waveform. The system further includes an arrhythmia detection module that detects the presence of an arrhythmia based on the cardiac potentials and generates an arrhythmia indicator, and an arrhythmia analysis module that assesses the severity of the detected arrhythmia. The arrhythmia analysis module calculates average sinus pulse information based on the pulse waveform data for two or more cardiac cycles occurring when no arrhythmia is detected, and then calculates average arrhythmia pulse information based on pulse waveform data for two or more cardiac cycles occurring after detection of the arrhythmia.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: August 4, 2020
    Assignee: General Electric Company
    Inventor: Mikko Kaski
  • Patent number: 10682508
    Abstract: An electrically stimulated CBD infused anesthetic patch system that is placed on a human's skin that is used to relieve pain. The electrically stimulated CBD infused anesthetic patch system comprises of a transdermal patch that has electrodes that receive an electric current from a TENS device. The transdermal patch is impregnated with a solution that has at least one analgesic that is selected from the group consisting of Menthol, CBD, Lidocaine or Capsaicin. The solution shall also include inactive ingredients.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: June 16, 2020
    Inventors: Trevor Theriot, Quanqin Dai, Mark Julian, Joseph Horton, John Lasso
  • Patent number: 10596382
    Abstract: Systems and related methods for enhancing learning of a sound pattern or relating to a sound pattern are described. A sound output corresponding to the sound pattern is delivering to the subject, and a learning enhancing neural stimulus is delivered to a cranial nerve of the subject in association with the sound output. The neural stimulus may be, for example, a transcutaneous neural stimulus. In an aspect, the subject is prompted to mentally rehearse the sound pattern. Electrical control circuitry controls timing of delivery of sound outputs and neural stimuli. In some aspects, the system is implemented in connection with a personal computing device.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: March 24, 2020
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney
  • Patent number: 10596014
    Abstract: A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. A prosthetic device receives the command signal from the signal translating unit and manipulates the body part in response to the command signal.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: March 24, 2020
    Assignee: Washington University
    Inventors: Eric Claude Leuthardt, Kimberly Kreines, Nick Anderson
  • Patent number: 10583287
    Abstract: A method for aesthetic soft tissue treatment includes placing at least one applicator in contact with the patient's body. The applicator has at least one electrode. Electrotherapy and radio frequency therapy are provided to the soft tissue, optionally with overlay or sequentially. A handheld applicator may be used, with the applicator moving during the therapy, which may provide muscle stimulation in the patient, or provide an analgesic effect during the treatment. A spacing object may be positioned between the skin of the patient and the applicator.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 10, 2020
    Assignee: BTL MEDICAL TECHNOLOGIES S.R.O.
    Inventor: Tomás Schwarz
  • Patent number: 10586997
    Abstract: A redox flow battery is described herein that has a sodium-super-ionic-conductor NaSICON barrier disposed between an anolyte chamber of the battery and the catholyte chamber of the battery. The NaSICON barrier prevents crossover of solvents or active redox species between the anolyte chamber and the catholyte chamber, while permitting transport of sodium ions between the chambers. In exemplary embodiments, the anolyte chamber includes an anolyte solution that comprises a first active redox species dissolved in a first solvent, while the catholyte chamber includes a catholyte solution that comprises a second active redox species dissolved in a second solvent.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 10, 2020
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: David Ingersoll, Ganesan Nagasubramanian, Eric Allcorn
  • Patent number: 10568551
    Abstract: A hearing diagnosis device and a hearing diagnosis method are provided. The device includes a storage unit, an otoacoustic emission detecting module, and a hearing diagnosis management module. The storage unit stores a hearing diagnosis image sample database and a hearing information sample database. The otoacoustic emission detecting module is configured to perform an otoacoustic emission detecting operation by playing a test audio to an ear of a user to obtain a first hearing diagnosis image corresponding to the ear. The hearing diagnosis management module is configured to perform a hearing diagnosis operation according to the first hearing diagnosis image, a plurality of hearing diagnosis image samples of the hearing diagnosis image sample database, and a plurality of hearing information samples, respectively corresponding to the hearing diagnosis image samples, of the hearing information sample database, so as to determine first hearing information of the ear.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 25, 2020
    Assignee: National Tsing Hua University
    Inventors: Hau-Tieng Wu, Pa-Chun Wang, Yi-Wen Liu
  • Patent number: 10561461
    Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are methods of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: February 18, 2020
    Assignee: Axon Therapies, Inc.
    Inventors: Dorin Panescu, Andrew Wu, Zoar Jacob Engelman, Mark Gelfand, Mark S. Leung, Howard Levin
  • Patent number: 10556121
    Abstract: Methods and apparatuses (including systems, devices, etc.) for the treatment of neurological disorders, and particularly multiple sclerosis (MS) by the application of electromagnetic fields (EMF), and in particular, pulsed electromagnetic fields (PEMF), including a subset of PEMF in a radio frequency domain (e.g., pulse-modulated radio frequency or PRF). This treatment may prevent or delay the onset, and/or may reduce the severity of the onset of MS and MS-related symptoms.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: February 11, 2020
    Assignee: Endonovo Therapeutics, Inc.
    Inventor: Blake Taylor Gurfein
  • Patent number: 10548578
    Abstract: A device for automatically registering the penetration depth of an invasive instrument into an opening and the rotational orientation of an invasive instrument in an opening of a body with the aid of a length-selective and rotation-selective pattern applied to the surface of the instrument, wherein the device has a sensor embodied to surround the instrument in a ring-shaped manner. According to the invention, the sensor is embodied for registering the length-selective and rotation-selective pattern and embodied and provided for the temporary arrangement in the region of the opening for the insertion of the invasive instrument. The device according to the invention has an evaluation unit for evaluating the penetration depth and the rotational orientation of an invasive instrument on the basis of the registered selective pattern.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: February 4, 2020
    Assignee: Karl Storz SE & Co. KG
    Inventor: Ulrich Gruhler
  • Patent number: 10537732
    Abstract: A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 21, 2020
    Assignee: FLOWAID MEDICAL TECHNOLOGIES CORP.
    Inventors: Zvi Nachum, Yaakov B. Brezel, Shalom Lampert
  • Patent number: 10532202
    Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: January 14, 2020
    Assignee: VOMARIS INNOVATIONS, INC.
    Inventors: Jeffry Skiba, Inder Raj S. Makin
  • Patent number: 10471257
    Abstract: Systems and methods of reducing pain after surgery in the thoracic or abdominal region and managing chronic nerve pain in the thoracic or abdominal region are provided. Such methods involve an electrode assembly that has a proximal portion and a distal portion with the distal portion including a plurality of electrodes. At least one electrode of the plurality of electrodes is placed over each of a plurality of intercostal nerve bundles in the patient's body. The proximal portion of the electrode assembly is connected to a pulse generator. An electromagnetic field is applied to the plurality of intercostal nerve bundles. The plurality of electrodes is removed from the patient's body after an intercostal nerve block sufficient to alleviate the patient's pain has been achieved.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 12, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Usman Ahmad, Sudish Murthy, Jonathan Sakai
  • Patent number: 10463531
    Abstract: A system is provided for stimulating a portion of skin, the system including at least two electrodes; a motor and an electrical system, the electrical system including a power source; and an end effector operably coupled to the motor and the electrical system, the end effector having at least one embedded electrode, from the at least two electrodes, disposed and operably coupled to the electrical system at which the end effector is configured to be in electrical communication with the portion of skin, wherein the motor is configured to subject the end effector to repetitive movements while contacting the skin to provide mechanical stimulation to the skin, wherein the at least one embedded electrode is configured to serve as a source electrode and another of the at least two electrodes is configured to serve as a return electrode, and wherein the power source is configured to bias the source electrode to the return electrode and form an electric field with the portion of skin.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: November 5, 2019
    Assignee: L'OREAL
    Inventors: Kaye Brunson, Lilac Muller, Zane Bowman Allen Miller, Vincenzo Casasanta, III
  • Patent number: 10463299
    Abstract: System for determining the effectiveness of various prescribed medications. Here a variety of different types of patient pulse wave measurements (e.g. blood pressure, pulse oximeter, ECG) and other physiological measurements are obtained. This actual data is compared to calculated measurements that would be expected based on the various patient baseline measurements in the absence of medication, schedule of medications, and impact of medications the various patient baseline measurements. If the actual data meets expectations, then the medication is likely acting as anticipated. Depending on which types of data do not meet expectations, problems with one or more previously described medications may be reported. Other types of patient physiological readings, such as temperature, motion, lung function, brain wave function (EEG) and the like may also be obtained, and these additional types of readings can be used to extend the range of different types of drugs/medications that the system can successfully monitor.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: November 5, 2019
    Assignee: Cloud Dx, Inc.
    Inventors: Sandeep S. Kohli, David Widman, Robert Kaul, Sara Ross-Howe
  • Patent number: 10450181
    Abstract: A system for achieving the sensation of drinking a particular drink, known as the target liquid, when in fact another drink, such as water, is being consumed. The system consists of a glass which contains not only water but also a small amount of the target liquid, in order to provide the true smell and image of the desired drink, as well as an electronic system for generating a series of signals which, by means of electrodes, stimulate the user's tongue to act on a series of nerve cells and provide the brain with a signal as similar as possible to that which the real drink provides to the taste buds of the user. The user of the system thus has the sensation of drinking the target liquid.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: October 22, 2019
    Inventor: Alberto Adarve Lozano
  • Patent number: 10441793
    Abstract: An implantable leadless pacemaker (iLP) for a human or animal heart, wherein the iLP includes a housing, at least two electrode poles for picking up electrical potentials and/or delivering electrical stimulation, a stimulation control unit in connection with the electrode poles, a sensing unit that is in connection with at least one electrode pole, a signal processing unit in connection with the sensing unit, a signal evaluation unit in connection with the signal processing unit and/or the sensing unit, and an energy source. The sensing unit is configured to sense a first signal associated with an activity of the first heart chamber, and the stimulation control unit is configured to deliver electrical stimulation in the first heart chamber via the at least two electrode poles. wherein the sensing unit is configured to sense a second signal associated with an activity of a second heart chamber.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: October 15, 2019
    Assignee: Biotronik SE & Co. KG
    Inventors: Dirk Muessig, Andrew B. Kibler, Larry Stotts
  • Patent number: 10420496
    Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 24, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Bahar Reghabi, James L. Henke, Wayne A. Morgan, Gopikrishnan Soundararajan, David Y. Choy, Peter Schultz, Udo Hoss
  • Patent number: 10406056
    Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: September 10, 2019
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Grégoire Courtine, Silvestro Micera, Joachim Von Zitzewitz
  • Patent number: 10398664
    Abstract: The present invention relates to methods for treating microbial infections on the surfaces of an implant or other surfaces near an implant in a patient. In particular, the methods are useful for treating biofilm infections. The methods include the use of minimally invasive techniques, including the use of ultra sound for facilitating the detection of biofilm infections on the implant or other surface of a patient and destroying the infection by administering an anthocyanin or an anthocyanidin or metabolite thereof. In particular, the administration of protocatechuic acid (PCA) or 2,4,6 trihydroxybenzaldehyde (2,4,6 THBA) for the treatment of an infected implant or other surface of a patient is described herein.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: September 3, 2019
    Inventor: Lanny Leo Johnson
  • Patent number: 10357646
    Abstract: An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric field across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: July 23, 2019
    Assignee: Highland Instruments
    Inventors: Timothy Andrew Wagner, Uri Tzvi Eden
  • Patent number: 10352948
    Abstract: A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: July 16, 2019
    Assignee: Impulse Dynamics NV
    Inventors: Benny Rousso, Yuval Mika, Shlomo Ben Haim, Hani N. Sabbah
  • Patent number: 10342445
    Abstract: A system and method of monitoring electrocardiogram (ECG) signals and detecting ischemic conditions. In particular, high-frequency components and low-frequency components are extracted from the monitored ECG signal. The high-frequency components are analyzed to detect reduced amplitude zones (RAZs), while the low-frequency components are utilized to detect premature ventricular contraction (PVC) beats. Potentially ischemic conditions are identified based on both RAZs and PVC beats detected.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: July 9, 2019
    Assignee: Medtronic Monitoring, Inc.
    Inventors: ShaileshKumar V. Musley, Maneesh Shrivastav, Stacie Vilendrer
  • Patent number: 10325387
    Abstract: A disclosed state display method includes: determining which of a first period and a second period is dominant in a designated period based on chronological measurement results of vital activities of a subject in the designated period, the first period being a period that has been determined that the subject is in a sleep state, the second period being a period that has been determined that the subject is in a non-sleep state; and changing configuration of a display screen that displays information related to states of the subject in the designated period according to a result of the determining.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: June 18, 2019
    Assignee: FUJITSU LIMITED
    Inventors: Takayuki Yamaji, Kiyoshi Kawano
  • Patent number: 10315030
    Abstract: Methods, devices and systems for improving pelvic floor dysfunction in a patient suffering therefrom by electrically modulating neural tissue in a minimally invasive fashion using an electrical microstimulator are provided. Methods include inserting an electrical microstimulator having a re-deployable fixation member through skin of a patient's leg and advancing the electrical microstimulator through the skin along tissue of a surgical pathway to an area of the patient's leg. A target implant site can be identified that is above deep fascia and below the skin and that is adjacent to a target nerve associated with pelvic floor function. The electrical microstimulator can be anchored to the target implant site via the re-deployable fixation member or re-positioned, if necessary. A therapy electrical signal can be delivered to the target nerve from the target implant site.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 11, 2019
    Assignee: VERESSA MEDICAL, INC.
    Inventors: Benjamin A. Tranchina, Tracy L. Cameron, Jeffrey Richard Held, Jeff Weisgarber, Michael S. Labbe, Maekele Gebrekidan, Mohsin Zafar, Eric Gustin Hassenpflug, Alexandru Campean, Robert K. Deckman, Steven E. Wilder
  • Patent number: 10286213
    Abstract: An apparatus (10) for applying stimulation therapy to a patient includes an implantable medical device (20) and a remote controller (50) for inductively powering the medical device and communicating with the medical device. The remote controller (50) includes a feedback portion (220) for helping to establish a communication link between the remote controller and the implantable medical device (20).
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 14, 2019
    Assignee: AUTONOMIC TECHNOLOGIES, INC.
    Inventors: Kellie Fletcher, Patrick Hard, Anthony V. Caparso, Karen Tsuei