Electrical Therapeutic Systems Patents (Class 607/2)
  • Patent number: 11364379
    Abstract: A patch for a therapeutic electrical stimulation device includes a shoe connected to the first side of the patch, the shoe including a body extending in a longitudinal direction from a first end to a second end, and having first and second surfaces, the first end of the shoe defining at least two ports, and the first surface of the shoe defining a connection member. The patch also includes at least one conductor positioned in the ports of the first end of the shoe. The shoe is configured for sliding insertion into a receptacle defined by a controller so that the conductor is connected to the controller to deliver electrical current from the controller, through the conductor, and to the electrodes, and the connection member is at least partially captured by a detent defined by the controller in the receptacle to retain the shoe within the receptacle.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: June 21, 2022
    Assignee: DJO, LLC
    Inventors: Thomas Jerome Bachinski, Richard Paul Shindley, Dennis Lutz
  • Patent number: 11351392
    Abstract: A pulsed electromagnetic field (PEMF) device includes at least one electromagnetic (EM) field emitter. During post-birth recovery, a patient applies the EM field emitter to herself. The PEMF device performs a recovery cycle. In the recovery cycle, the EM field emitter emits EM fields having frequency combinations with a response frequency and a target frequency for a frequency combination period.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: June 7, 2022
    Assignee: MY MOMMY MAGIC, LLC
    Inventors: Heather Taylor, David G. Brinkerhoff
  • Patent number: 11344724
    Abstract: A method and an apparatus for treating a patient suffering from, or at risk for, a condition mediated by the inflammatory cytokine cascade, by electrically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: May 31, 2022
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Jared M. Huston, Kevin J. Tracey
  • Patent number: 11331472
    Abstract: A device for delivery of electrical current to an area of the skin includes a first pad shaped in the form of a base having four finger-shaped protrusions; a second pad shaped in the form of a palm having a single thumb-shaped protrusion, where the first pad and the second pad each comprises a conductive layer and preferably has tabs on the edges; a first electrical connection system electrically connected to the conductive layer of the first pad; a second electrical connection system electrically connected to the conductive layer of the second pad; a controller circuit connected to the first electrical connection system and second electrical connection system; and a wearable power source. Alternatively, the device may also have the shape of a foot or other body part.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: May 17, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Justin H. Huelman, Véronique Paule-Alberte D Peiffer
  • Patent number: 11331477
    Abstract: A neurostimulation (NS) system and method are provided. The system includes a power supply having positive and negative terminals. The negative terminal defines a reference ground. An array of electrodes includes first and second active electrodes for delivering stimulation therapy configured to be located proximate to neural tissue of interest that is associated with a target region. A control circuit is configured to control delivery of stimulation current for a NS therapy between the first and second electrodes. A current regulator (CR) circuit is connected to, and configured to control current flow through, at least the first electrode during delivery of the stimulation therapy under direction of the control circuit. A floating power supply is connected across power supply terminals of the CR circuit. The CR circuit and floating power supply are coupled to a floating ground node that is electrically separate from the reference ground.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: May 17, 2022
    Assignee: ADVANCED NEUROMODULATION SYSTEMS, INC.
    Inventors: Steven Boor, Daran DeShazo, Gavin L. Rade
  • Patent number: 11331494
    Abstract: A local stimulation method of a predetermined region of brain tissue, the brain tissue including at least GABAergic neuron type. The method includes at least one activation step of a set of bipolar electrodes, according to a predetermined electric intensity and a predetermined biphasic pulse frequency, delivering a predetermined electric field. The predetermined electric field induces an activation of the GABAergic type neurons and a virtual absence of activation of other types of neurons.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 17, 2022
    Assignees: UNIVERSITE DE RENNES 1, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Pascal Benquet, Fabrice Wendling, Julien Modolo
  • Patent number: 11318296
    Abstract: Techniques are disclosed to automate determination of therapy parameter values for adaptive deep brain stimulation (aDBS). A medical device may determine differences in power values between a present and a previous power value. Based on the difference being greater than or equal to a threshold value, the medical device may iteratively adjust a present therapy parameter value until the difference in the power values between a present and a previous power value is less than the threshold value.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 3, 2022
    Assignee: MEDTRONIC, INC.
    Inventors: Yizi Xiao, Eric J. Panken, Scott R. Stanslaski, Jadin C. Jackson, Christopher Pulliam
  • Patent number: 11311205
    Abstract: Systems and methods for evaluating neuromodulation via hemodynamic responses are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a neuromodulation catheter comprising an elongated shaft having a distal portion, and a plurality of electrodes spaced along a distal portion. The system can further include a controller communicatively coupled to the electrodes. The controller can be configured to apply first and second stimuli at and/or proximate to a target site within a blood vessel before and after delivering neuromodulation energy to the target site, and detect, via at least one of the electrodes, vessel impedance resulting from the first and second stimuli to determine a baseline impedance and a post-neuromodulation impedance. The controller can further be configured to assess the efficacy of the neuromodulation based, at least in part, on a comparison of the baseline impedance and the post-neuromodulation impedance.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: April 26, 2022
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Douglas Hettrick, Avram Scheiner
  • Patent number: 11305119
    Abstract: An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: April 19, 2022
    Assignee: ZOLL RESPICARDIA, INC.
    Inventors: Mark Gelfand, Howard R. Levin, Andrew Halpert
  • Patent number: 11304651
    Abstract: A system is provided for monitoring patients with dysphagia, or swallowing impairments, that monitors muscle movement during intensive swallowing exercises to provide adjuvant visual feedback from surface electromyography.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: April 19, 2022
    Assignees: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, COVENANT HEALTH
    Inventors: Jana Maureen Rieger, Gabriela Constantinescu, Mark James Redmond, Dylan Kyle Scott, Benjamin Ronald King, Mark Vernon Fedorak, Herman Lundgren
  • Patent number: 11298543
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: April 12, 2022
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Jeffrey L. Ardell
  • Patent number: 11298539
    Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region from an epidural, cervical location to address at least one of high back pain, mid-back pain, low back pain, and leg pain without creating paresthesia in the patient.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: April 12, 2022
    Assignee: Nevro Corp.
    Inventors: James R. Thacker, Konstantinos Alataris, Bradford Evan Gliner
  • Patent number: 11298063
    Abstract: A system and method to handle urine includes collecting urine using a pad or garment, exposing the urine to an aluminum alloy to generate hydrogen gas and heat in an exothermic reaction, and storing the hydrogen in a sealed chamber.
    Type: Grant
    Filed: October 20, 2019
    Date of Patent: April 12, 2022
    Inventor: Bao Q Tran
  • Patent number: 11298538
    Abstract: A system may include at least one sensor configured to bilaterally sense neurophysiological signals from the patient to provide bilateral sensing data, and at least one processor configured to calibrate at least a first electrode contact and a second electrode contact on the least one neuromodulation lead, including: instruct the neuromodulation device to deliver neuromodulation energy using at least the first electrode contact to cause a first neurophysiological response and at least the second electrode contact to cause a second neurophysiological response; receive from the at least one sensor first bilateral sensed data corresponding to the first neurophysiological response and second bilateral sensed data corresponding to the second neurophysiological response; and determine based on the first and second neurophysiological responses at least one of: physiological midline information or electrode-tissue coupling information.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: April 12, 2022
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Ismael Huertas Fernandez, Que T. Doan
  • Patent number: 11287503
    Abstract: Methods and systems for controlling patient stimulating effects in MR imaging. The methods and systems include calculating a first effective stimulus duration independently for each pulse flank of an MRI sequence individually and calculating a second effective stimulus duration for which a respective history of a changing gradient field during the sequence is taken into account. Dependent on an evaluation of both the first and second effective stimulus durations a threshold value for an allowable rate of change in the magnetic gradient field is then calculated. The respective MRI sequence is then evaluated against the calculated threshold value to determine whether or not the respective MRI sequence is safe to apply.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: March 29, 2022
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Daniel Niederlöhner, Gudrun Ruyters, Axel vom Endt
  • Patent number: 11278721
    Abstract: The present disclosure provides a device for state-dependent pudendal nerve stimulation for bladder control in a subject and methods of making and using the same.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: March 22, 2022
    Assignee: DUKE UNIVERSITY
    Inventors: Warren M. Grill, James A. Hokanson, Christopher L. Langdale
  • Patent number: 11260228
    Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: March 1, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Samuel J. Asirvatham
  • Patent number: 11260225
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A nerve stimulator is configured for coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The stimulator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: March 1, 2022
    Assignee: ELECTROCORE, INC
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon
  • Patent number: 11253699
    Abstract: A medical lead includes a lead body, a connector pin proximate to a proximal end of the lead body, a helix extending from a distal end of the lead body, an electrode proximate to the distal end of the lead body, and a cable conductor within the lead body and including an electrode proximate a distal end of the cable conductor, the cable conductor being slideable within the lead body to extend and retract the electrode relative to the distal end of the lead body.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: February 22, 2022
    Inventors: Terrell M. Williams, Gopi Dandamudi
  • Patent number: 11253728
    Abstract: Embodiments of the present disclosure are directed to radiotherapy systems. An exemplary radiotherapy system may comprise a radiotherapy output configured to deliver a charged particle beam to a patient. The system may also comprise a detector array. The detector array may have an axis that extends parallel to an axis along which the charged particle beam is delivered by the radiotherapy output. The detector array may comprise a plurality of detectors configured to detect a magnetic field generated by the charged particle beam during delivery of the charged particle beam from the radiotherapy output.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: February 22, 2022
    Assignee: Elekta Pty Ltd.
    Inventor: Stuart Julian Swerdloff
  • Patent number: 11241577
    Abstract: This application discloses configurations for arranging transducer arrays on a person's head to impose tumor treating fields (TTFields) in the brain at field strengths that are as uniform as possible throughout the entire brain. In some embodiments, L-shaped sets of electrodes are positioned near the right and left ears, each with a horizontal arm above the ear and a vertical arm behind the ear. Optionally, these embodiments may be combined with a second pair of electrodes positioned on top of the head and behind the neck. In other embodiments, one pair of electrodes is positioned above the right ear and on the left/rear portion of the neck; and a second pair of electrodes is positioned above the left ear and on the right/rear portion of the neck. These configurations improve the uniformity of the electric fields imposed throughout the brain, and are particularly useful for preventing and/or treating metastases.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: February 8, 2022
    Assignee: Novocure GmbH
    Inventors: Zeev Bomzon, Ariel Naveh, Ofir Yesharim
  • Patent number: 11241239
    Abstract: An occlusive implant includes an expandable framework that is configured to shift between a collapsed configuration and an expanded configuration. An occlusive member is disposed along at least a portion of the expandable framework. At least part of the occlusive implant is configured to repel fibrinogen. In some cases, the occlusive implant may be configured for placement within a left atrial appendage (LAA) of a patient's heart.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: February 8, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Hong Cao, Dongming Hou, Hongxia Zeng
  • Patent number: 11229789
    Abstract: A neuro activation system includes a patch adapted to be applied externally on a dermis of a user, the patch comprising a flexible substrate and an adhesive on a first side adapted to adhere to the dermis of the user, an electronic package directly coupled to the substrate, the electronic package including a control unit and one or more stimulators, and electrodes directly coupled to the substrate and the electronic package, the patch adapted to generate an electrical stimuli via the electrodes. The neuro activation system further includes a controller in wireless communication with the patch, the controller including remote functionality to start and stop the electrical stimuli.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: January 25, 2022
    Assignee: NEUROSTIM OAB, INC.
    Inventors: Terry Spurling, Anthony Wei, Michael Bernard Druke, Hoo-min D. Toong
  • Patent number: 11218142
    Abstract: An electronic device includes a multiplexer (MUX), a switching array and logic circuitry. The MUX includes multiple input ports and an output port, and is configured to receive, via the input ports, multiple input signals, and to output, via the output port, a selected signal among the input signals. The switching array is coupled to the input ports of the MUX and is configured to receive the input signals and to connect or disconnect between each input signal and a respective input port. The logic circuitry is electrically coupled to the switching array and to the MUX, and is configured to control the switching array to connect at least the selected signal that the MUX is outputting, and to disconnect all the input signals other than the at least selected signal.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 4, 2022
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventor: Assaf Govari
  • Patent number: 11207516
    Abstract: Disclosed is a distributed transformer or extension cord component for a transcutaneous energy transfer system used to transfer electric power to an implanted medical device. The extension cord component may enable power transfer to occur at various points on or near the body of the subject within whom the medical device is implanted. In this way, the subject may gain greater flexibility and high levels of convenience in connection with use of the transcutaneous energy transfer system.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: December 28, 2021
    Assignee: Minnetronix, Inc.
    Inventors: Vlad Bluvshtein, Lori Lucke
  • Patent number: 11202596
    Abstract: A system and methods utilizing electrical stimulation to achieve a desired therapeutic effect are provided. In one aspect, a method for controlling nerve activity in a subject is provided. The method includes receiving input indicating a desired therapeutic effect for at least one neural structure of a subject, and selecting, based on the input received, an electrical stimulation configured to achieve the desired therapeutic effect. The method also includes controlling a sympathetic nerve activity in the subject by delivering the electrical stimulation using electrodes positioned proximate to nerves innervating the subject's skin.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: December 21, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Peng-Sheng Chen, Lan S. Chen
  • Patent number: 11191948
    Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: December 7, 2021
    Assignee: Vomaris Innovations, Inc.
    Inventors: Jeffry Skiba, Inder Raj S. Makin
  • Patent number: 11191954
    Abstract: This document discusses, among other things, systems and methods for programming neuromodulation therapy to treat neurological or cardiovascular diseases. A system includes an input circuit that receives a modulation magnitude representing a level of stimulation intensity, a memory that stores a plurality of gain functions associated with a plurality of modulation parameters, and a electrostimulator that may generate and deliver an electrostimulation therapy. A controller may program the electrostimulator with the plurality of modulation parameters based on the received modulation magnitude and the plurality of gain functions, and control the electrostimulator to generate electrostimulation therapy according to the plurality of modulation parameters.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: December 7, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Goran N. Marnfeldt, Michael A. Moffitt
  • Patent number: 11191955
    Abstract: Devices, systems, and methods for accessing the internal and external tissues of the heart are disclosed. At least some of the embodiments disclosed herein provide access to the external surface of the heart through the pericardial space for localized delivery of substances to the heart tissue. In addition, various disclosed embodiments provide access to the internal surface of the heart for aspiration and delivery of substances to a targeted region without disturbing or interfering with nearby structures or surfaces.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: December 7, 2021
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 11179568
    Abstract: Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: November 23, 2021
    Assignee: Boston Scientific Neuromodufation Corporation
    Inventors: Rafael Carbunaru, Kelly H. McClure, Jordi Parramon
  • Patent number: 11167139
    Abstract: Apparatus and methods for managing pain uses a single composite modulation/stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals, including spinal cord stimulation or peripheral nerve stimulation.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: November 9, 2021
    Assignee: Medtronic SG, LLC
    Inventors: Ricardo Vallejo, David Leonardo Cedeno, Nathan A. Torgerson, Brian Andrew Smith
  • Patent number: 11147942
    Abstract: A system comprises a flexible pad, an antenna wire disposed within the flexible pad, and an electronics unit connected to or capable of being connected to the antenna wire. The electronics unit can include circuitry configured to access a stored playlist representing a sequence of tones at different frequencies, and to generate signals representing the tones such that two or more of the tones are generated in the sequence according to the stored playlist. The electronics unit further can include an oscillator to generate a carrier signal and coupled so that the signals representing the tones modulate the carrier signal according to the sequence when applied to an input of the oscillator, where the oscillator has an output connected to transmit the modulated carrier signal onto an antenna when the electronics unit is in operation.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: October 19, 2021
    Assignee: KUNASAN LLC
    Inventor: Paul Mawson
  • Patent number: 11145409
    Abstract: An automatic external defibrillator (AED) is described which is leased for an at-risk patient and designed for use in a single cardiac emergency. If the AED is in standby for a year without being deployed, the AED is removed from service and replaced with another AED. The AED requires a rescuer only to deploy the electrodes on the torso of the victim; the AED turns itself on, performs rhythm analysis and delivers a shock if needed automatically. The AED thus requires no user controls. Preferably the AED requires no on-site maintenance, as the AED communicates its readiness for use to a remote monitoring site which responds to any problems detected by self-testing. In addition to its electro-resuscitation function, the AED can be used on the chest of the victim to administer CPR compressions.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: October 12, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Dawn Blilie Jorgenson, Catherine Anne Thompson
  • Patent number: 11123561
    Abstract: A treatment system for stimulating the vagus nerves is described, comprising the following elements: —a detection and control unit (20); —at least one detection probe (10d, 10g) connected to the detection and control unit and intended to be applied to at least one of the two vagus nerves of a patient; —means (24) provided in the detection and control unit for detecting a phenomenon of mass discharge of action potentials in at least one vagus nerve using the detection probe or detection probes; —stimulation probes (10d, 10g) for stimulating vagus nerves, and—means (24) provided in the detection and control unit that are capable, in response to the detection of a mass discharge, of applying predefined asymmetric stimulation signals to said stimulation probes capable of causing a depolarization and/or hyperpolarization of the vagus nerves and of blocking the conduction of the action potentials at least in the efferent direction.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: September 21, 2021
    Assignees: UNIVERSITE DE RENNES 1, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC, CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CHU DE RENNES (CENTRE HOSPITALIER UNIVERSITAIRE DE
    Inventors: Alfredo Hernandez, Benoit Martin, Arnaud Biraben
  • Patent number: 11123411
    Abstract: Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed formulations include botulinum neurotoxin (e.g., botulinum neurotoxin or a fragment thereof, either in pure form or with one or more peptide fragments and/or neurotoxin associated proteins). In some embodiments, the disclosed formulations also include one or more anti-VEGF agents. The disclosed formulations may be applied to an intraocular or extraocular region of a patient.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: September 21, 2021
    Inventor: Gary E. Borodic
  • Patent number: 11123412
    Abstract: Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed formulations include botulinum neurotoxin (e.g., botulinum neurotoxin or a fragment thereof, either in pure form or with one or more peptide fragments and/or neurotoxin associated proteins. In some embodiments, the disclosed formulations are applied to the para orbital or periorbital region of a patient to delay or stop the progression of dry macular degeneration. The methods described herein do not involve a direct injection into the eye or subconjunctival region, thus significantly easing both comfort and administration related complications and further preserving barrier functions of retinal layers while also delaying or ceasing the degenerative process to wet conversion.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: September 21, 2021
    Inventor: Gary E. Borodic
  • Patent number: 11123562
    Abstract: The present invention relates to systems, devices and methods for acquiring, measuring, monitoring, processing and analyzing physiological signals. More particularly, the present invention relates to using physiological signals to determine a subject's response to various conditions, variables or constraints. Still more particularly, the present invention relates to monitoring the subject's external body motion and/or environmental factors and determining the amount of pain a subject is suffering as a result of the motion and factors. Still more particularly, the present invention relates to a system, device and methods of quantifying a subject's pain to provide an objective measurement of the subject's pain. The present invention further relates to establishing and improving pain management protocols and therapy or treatment for the subject's pain based on the quantified pain measurement.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: September 21, 2021
    Assignee: Great Lakes NeuroTechnologies Inc.
    Inventors: Christopher L Pulliam, Joseph P Giuffrida
  • Patent number: 11097109
    Abstract: A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: August 24, 2021
    Assignee: ATACOR MEDICAL, INC.
    Inventors: Rick Sanghera, Alan Marcovecchio, Sean P. McGeehan
  • Patent number: 11076789
    Abstract: The subject of the invention is a system for collecting medical data such as heart rate, breathing frequency, intracranial pressure, apnea and others, and method of use thereof. The present invention provides a unique way of collecting medical data, in particular in their acquisition from a plurality of measuring elements.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: August 3, 2021
    Assignee: LINET SPOL. S.R.O
    Inventor: Vladimir Kolar
  • Patent number: 11077019
    Abstract: An auricular peripheral nerve field stimulator includes at least one therapy electrode configured for percutaneous insertion into an auricle of a human ear near at least one neurovascular bundle, and an electrical stimulation device electrically coupled to the at least one therapy electrode, the electrical stimulation device programmed to (i) generate and deliver electrical stimulation signals to the inserted at least one therapy electrode at a selected frequency for a selected duration to stimulate at least one auricular peripheral nerve field within the auricle, and (ii) repeat (i) with the stimulation signals having a modulated frequency.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: August 3, 2021
    Assignee: Innovative Health Solutions, Inc.
    Inventors: Christopher R. Brown, Gary M. Peterson
  • Patent number: 11077304
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: August 3, 2021
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Patent number: 11074459
    Abstract: A system for monitoring a patient in a patient area having one or more detection zones, the system comprising one or more cameras, a user interface, and a computing system configured to receive a chronological series of frames from the one or more cameras, identify liquid candidates by comparing a current frame with a plurality of previous frames of the chronological series, determine locations of the liquid candidates, identify thermal signatures of the liquid candidates, determine types of liquids of the liquid candidates based on the locations and thermal signatures of the liquid candidates, and generate an alert with the user interface corresponding to the determined types of liquids.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: July 27, 2021
    Assignee: CareView Communications, Inc.
    Inventors: Steven Gail Johnson, Derek del Carpio, Kenneth W. Chapman
  • Patent number: 11071861
    Abstract: Prophylactic stimulation and abortive electrical stimulation are delivered to a cranial nerve, including, e.g. an occipital or trigeminal nerve to treat symptoms of various conditions, including, e.g. occipital neuralgia or migraines.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: July 27, 2021
    Assignee: Medtronic, Inc.
    Inventors: Martin T. Gerber, Steven M. Goetz, Christopher Poletto
  • Patent number: 11073508
    Abstract: Ligand-ion channel interactions are analyzed via electrophysiological methods having rapid temporal response and high sensitivity, thereby reducing the collection time and enabling monitoring of dynamic processes. This protocol allows quantification of ligand concentrations in the sub-millisecond to ms range, as compared to s-min for traditional approaches. Moreover, the method can be easily integrated into existing patch clamp analysis packages and allow for monitoring of rapid, dynamic chemical processes in a feasible manner.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: July 27, 2021
    Assignee: Arizona Board of Regents on Behalf of the University Of Arizona
    Inventors: Craig Alan Aspinwall, Steven Scott Saavedra, Mark Tadashi Agasid
  • Patent number: 11071672
    Abstract: A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 27, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Jason D. Harry, James J. Collins, James B. Niemi, Attila A. Priplata, Stephen J. Kleshinski
  • Patent number: 11052254
    Abstract: Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: July 6, 2021
    Assignee: ENDOSTIM (ABC), LLC
    Inventors: Ofer Glasberg, Shai Policker, Virender K. Sharma, Paul V. Goode, Bevil Hogg
  • Patent number: 11039888
    Abstract: Systems and methods are described for planning of catheter ablation procedures, and in particular for planning of the placement of lesions and/or parameters used in ablation. In some embodiments, planning is based on thermal and/or dielectric simulation of lesions, individualized to the anatomy of the particular patient. Optionally, a plan comprises planning of a path along which an ablation lesion is to be formed, the ablation lesion optionally comprising one or more sub-lesions. The plan is optionally optimized for one or more criteria including, for example: minimization of path length, minimization of sub-lesion number, simplification of catheter maneuvering, avoidance of collateral damage to non-target tissue, access to the target dependent on anatomy shape and/or catheter mechanics, and/or features of the target anatomy such as tissue wall thickness and/or fiber direction.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: June 22, 2021
    Assignee: Navix International Limited
    Inventors: Yitzhack Schwartz, Zalman Ibragimov, Yehonatan Ben David, Eli Dichterman
  • Patent number: 11040197
    Abstract: Techniques are described for determining a voltammogram that characterizes a result of a fast-scan cyclic voltammetry process. The FSCV process can be performed using a sensing apparatus at least partially immersed in a volume of blood of a mammal. A system can process the voltammogram to determine a concentration of a neurochemical in the volume of blood of the mammal.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: June 22, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Kip A. Ludwig, Kendall H. Lee, Kevin E. Bennet, Evan N. Nicolai, Anders J. Asp
  • Patent number: 11020592
    Abstract: A system for providing electrical stimulation to a patient includes a processor configured to: provide a time-ordered arrangement of multiple stimulation instances, where each of the stimulation instances is configured to produce a different stimulation field from each other stimulation instance in the arrangement; provide an ON/OFF switch pattern that includes alternating ON periods and OFF periods; generate an intermittent stimulation program that corresponds to repetition of the arrangement of stimulation instances with omission of each of the stimulation instances occurring during the OFF periods; and initiate a signal that provides a pulse generator with instructions that enable the pulse generator to generate stimulation according to the intermittent stimulation program using an electrical stimulation lead coupled to the pulse generator.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: June 1, 2021
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Danil Tyulmankov, Hemant Bokil, Peter Alexander Tass
  • Patent number: 11020591
    Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical non-invasive stimulation of a nerve, such as the vagus nerve. A stimulator comprises a contact surface for contacting an outer skin surface of a patient and a pulse generator coupled to the contact surface. The pulse generator is configured for attachment and electrical coupling to a mobile device configured to receive a wireless signal, such as a mobile phone. The pulse generator is further configured to generate an electrical impulse and to transmit the electrical impulse through the contact surface and the outer skin surface of the patient to modulate a nerve within the patient.
    Type: Grant
    Filed: July 22, 2020
    Date of Patent: June 1, 2021
    Assignee: ELECTROCORE, INC.
    Inventors: Joseph P. Errico, Steven Mendez, Bruce J. Simon