Combined With Nonelectrical Therapy Patents (Class 607/3)
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Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
Publication number: 20120289763Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more passive cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more passive cooling elements is configured to be implantable, and wherein the one or more passive cooling elements includes a first portion configured to be in association with the one or more tissues to be cooled, and a second portion configured to be placed in association with one or more tissues adjacent to an external epidermal tissue of the vertebrate subject.Type: ApplicationFiled: May 9, 2011Publication date: November 15, 2012Inventors: Edward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K.Y. Jung, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney, Lowell L. Wood, JR. -
Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
Publication number: 20120290023Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.Type: ApplicationFiled: May 9, 2011Publication date: November 15, 2012Inventors: Edward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K.Y. Jung, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney, Lowell L. Wood, JR. -
Publication number: 20120290025Abstract: Techniques for delivering genetic material to a target tissue site of a patient via a leadless implantable medical device that includes a pump and a stimulation energy delivery element are described. In some examples, delivery of genetic material to the target tissue site causes transgene expression of tissue at the target tissue site, which may result in generation of new cells or modified properties of existing cells of the target tissue site, facilitating more effective and efficient treatment of a disorder of the patient.Type: ApplicationFiled: May 12, 2011Publication date: November 15, 2012Applicant: Medtronic, Inc.Inventor: John G. Keimel
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Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject
Publication number: 20120289758Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.Type: ApplicationFiled: September 1, 2011Publication date: November 15, 2012Inventors: Edward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K.Y. Jung, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney, Lowell L. Wood, JR. -
Patent number: 8311620Abstract: The invention provides a cardiac rhythm management system which includes a tachyarrhythmia detection and classification circuit programmed to detect and classify a tachyarrhythmia, a biologic therapy delivery device configured to deliver or regulate an expression cassette suitable for terminating or preventing atrial fibrillation (AF), and a control circuit coupled to the tachyarrhythmia detection and classification circuit and the biologic therapy delivery device. Also provided is an implantable medical device for use in a body having a cardiovascular system, which includes an implantable device body including at least a cardiovascular portion configured to be in the cardiovascular system, and an expression cassette incorporated into the cardiovascular portion of the implantable device body, the expression cassette selected to express a gene product that terminates or prevents AF. Further provided are methods which employ particular expression cassettes to prevent, inhibit or treat AF.Type: GrantFiled: August 22, 2007Date of Patent: November 13, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Jihong Qu, Haris J. Sih, Mark Schwartz, Prashant Sinha
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Patent number: 8306615Abstract: An implantable cardiac rhythm management (CRM) device delivers a chronic therapy while detecting an ischemic state. When the ischemic state indicates the occurrence of an ischemic event, the implantable CRM device delivers a post-ischemia therapy. The post-ischemia therapy and the chronic therapy are adjusted using feedback control with the ischemic state and parameters indicative of the effectiveness of the post-ischemic therapy and the effectiveness of the chronic therapy as inputs.Type: GrantFiled: January 18, 2010Date of Patent: November 6, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Marina V. Brockway, Joseph M. Pastore, Yi Zhang, Carlos Ricci, Allan C. Shuros, Rodney W. Salo
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Patent number: 8303579Abstract: The surgical operation system includes a treatment section for treating a living tissue of a treatment target; an ultrasound generation section for providing ultrasound to the treatment section; an ultrasound drive power supply section for supplying ultrasound drive power to generate ultrasound to the ultrasound generation section; a high-frequency power supply section for supplying high-frequency power to the treatment section; an impedance detection section for detecting the impedance of the ultrasound provided to the living tissue and the impedance of the high-frequency power supplied to the living tissue; and a control section for controlling the ultrasound energy amount and the amount of high-frequency power or a crest factor value thereof in response to the detected impedance values of ultrasound and high-frequency wave.Type: GrantFiled: December 31, 2008Date of Patent: November 6, 2012Assignee: Olympus Medical Systems Corp.Inventor: Norikiyo Shibata
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Patent number: 8300907Abstract: An object of the present invention is to easily maintain the couch positioning accuracy and reduce the couch positioning time while resolving the complexity of input operations by the operator at the time of couch positioning. To accomplish the above object, calculation points are set to a CT image at the time of treatment planning, and the 3D coordinates of the set calculation point are set to a DRR image. When a couch positioning unit 115 loads the DRR image from an image server 109, it reads the coordinates of calculation points set to the DRR image and displays them on the monitor 116 together with the DRR image. Further, when DR image data is loaded into the couch positioning unit 115, the DR image is displayed on the monitor 116 and calculation points set to the DRR image are set also to the DR image.Type: GrantFiled: January 23, 2008Date of Patent: October 30, 2012Assignee: Hitachi, Ltd.Inventors: Yoshihiko Nagamine, Toshie Sasaki, Takao Kidani
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Publication number: 20120271206Abstract: A device for massaging skin, including, a RF generator adapted to generate a radio frequency AC current to heat fat tissue in the adipose layer of the skin, an electrical pulse generator adapted to generate pulses of DC current to provide electrical muscle stimulation for the muscles below the adipose layer, an applicator including one or more heads adapted to be placed in contact with the user's skin; and wherein the heads serve as massage contacts to massage the outer layer of a user's skin above the adipose layer or as electrodes to deliver the AC current and DC current, or as both.Type: ApplicationFiled: November 16, 2010Publication date: October 25, 2012Inventors: Pinchas Shalev, Zion Azar
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Publication number: 20120270876Abstract: Methods are provided for treating a subject for a condition caused by an abnormality in the subject's autonomic nervous system. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is pharmacologically modulated with at least one beta-blocker in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.Type: ApplicationFiled: April 24, 2012Publication date: October 25, 2012Inventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee
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Patent number: 8295926Abstract: A method for treatment of obesity or other disorders by electrical activation or inhibition of nerves is disclosed. This activation or inhibition can be accomplished by stimulating a nerve using an electrode. The method further comprises performing a surgical procedure and/or administering a weight loss drug.Type: GrantFiled: October 23, 2009Date of Patent: October 23, 2012Assignee: Advanced Neuromodulation Systems, Inc.Inventor: John D. Dobak, III
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Publication number: 20120265262Abstract: A method, comprising detecting an epileptic event in a neural network, wherein the event occurs in a first node; identifying a second node; and applying a therapy to the second node or any connection. A method, comprising determining a first body index indicative of epileptic activity; monitoring a second body index; detecting an indication of activity spread, based upon at least the second body index; and taking a responsive action, such as delivering therapy, modifying therapy, logging the indication, or warning. A method, comprising detecting an epileptic event in a first node of a neural network; applying a first therapy to a first neural structure for treating the event; and applying a second therapy to a second neural structure of the patient based on an event spread proclivity to a third neural structure. A non-transitive, computer-readable storage device for storing data that when executed by a processor, perform a method.Type: ApplicationFiled: April 17, 2012Publication date: October 18, 2012Applicant: FLINT HILLS SCIENTIFIC, LLCInventor: Ivan OSORIO
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Patent number: 8290580Abstract: The provision of an potential therapeutic appliance for the delivery into living organisms of highly effective negative ions similar to those found in nature; and in particular, providing a special waveform shaping device that shapes the voltage waveforms delivered to electrodes to efficiently produce negative ions, that is capable of stable performance, and that can be easily manufactured. A waveform shaping device 3 charged with an inorganic insulating powder such as pumice stone powder and a predetermined volume of moisture is disposed in series between a high voltage power supply 2 and an output terminal 12; the current output from the negative terminal of the high voltage power supply is shaped by the waveform shaping device and then delivered to the output terminal; and in a repetitive process, the charge delivered from the high voltage power supply 2 is accumulated temporarily in a terminal 4 and discharged in a burst-like manner; thus facilitating convenient action of negative ions on the human body.Type: GrantFiled: July 26, 2004Date of Patent: October 16, 2012Inventors: Noboru Horiguchi, Hiroshi Horiguchi
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Patent number: 8290581Abstract: The present invention is directed to an apparatus that includes a microcurrent delivery device portion and at least one independent sensory cue delivery means. The independent sensory cue delivery means can provide an independent sensory cue selected from the group consisting of vibration, heat, cool, skin irritation, tingling, fragrance or auditory.Type: GrantFiled: October 30, 2008Date of Patent: October 16, 2012Assignee: McNeil-PPC, Inc.Inventors: Leo B. Kriksunov, Aliya Z. Omer, Edward Roche, Joshua Ghaim, Naomi Furgiuele
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Patent number: 8282580Abstract: The disclosure describes techniques for data rejection for posture state analysis. The techniques may include storing posture state data sensed by a medical device for a patient, rejecting any portion of the posture state data that was stored during a session that was shorter than a session threshold, and generating posture state output for the patient based on a portion of the posture state data that was not rejected.Type: GrantFiled: April 30, 2009Date of Patent: October 9, 2012Assignee: Medtronic, Inc.Inventors: Dennis M. Skelton, Jon P. Davis, Shyam Gokaldas, Rajeev Sahasrabudhe
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Publication number: 20120253417Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.Type: ApplicationFiled: June 14, 2012Publication date: October 4, 2012Applicant: NeuroPace Inc.Inventors: Benjamin D. Pless, Thomas K. Tcheng
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Publication number: 20120253416Abstract: A system and method for treatment of skin including a treatment surface having numerous small energy emitting points for fractional skin treatment as well as negative pressure outlets. During a treatment, negative pressure from the outlets may exert a pulling force on an opposing tissue surface to bring the tissue into contact with the energy points.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Inventors: Danny EREZ, Gerard Tal
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Patent number: 8275456Abstract: An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.Type: GrantFiled: June 20, 2006Date of Patent: September 25, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Steven D. Girouard, Qingsheng Zhu
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Patent number: 8271080Abstract: Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.Type: GrantFiled: May 23, 2007Date of Patent: September 18, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Julie A. Thompson, Yousufali H. Dalal
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Publication number: 20120232327Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.Type: ApplicationFiled: May 23, 2012Publication date: September 13, 2012Applicant: ADVANCED NEUROMODULATION SYSTEMS, INC.Inventors: Andres M. Lozano, Helen S. Mayberg
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Patent number: 8262714Abstract: The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.Type: GrantFiled: February 27, 2009Date of Patent: September 11, 2012Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Justin Hulvershorn, Bradford E. Gliner, Brian Kopell
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Patent number: 8260427Abstract: A garment is provided with a tube that may be used to facilitate placement of needle electrodes into a patient to facilitate intraoperative monitoring during surgical procedures.Type: GrantFiled: July 7, 2010Date of Patent: September 4, 2012Assignee: ProNerve, LLCInventors: Jeff Thramann, James Higgins
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Patent number: 8249705Abstract: Described here are devices, systems, and methods for improving left ventricular function in a patient with systolic heart failure with left ventricular dysfunction using baroreflex activation therapy. In general the systems have at least one electrode and a control system in communication with the electrode, the control system including a processor and memory, wherein the memory includes software defining a stimulus regime configured to effect improvement in left ventricular function. The methods for improving left ventricular function in a subject typically include identifying a patient in need of left ventricular function improvement and stimulating a baroreceptor with a baroreceptor activation device to improve left ventricular function.Type: GrantFiled: March 6, 2008Date of Patent: August 21, 2012Assignee: CVRx, Inc.Inventors: Robert S. Kieval, Martin Rossing
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Publication number: 20120209340Abstract: A device and method for stimulating nerves. In one application, the approaches treat nausea and vomiting caused by a reaction to general anesthesia. A bi-modal approach involving acustimulation and medicants is contemplated for specific conditions.Type: ApplicationFiled: January 4, 2012Publication date: August 16, 2012Inventor: Rafael Escribano
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Publication number: 20120209341Abstract: There is provided a method for controlling the movement of bile and/or gall stones in the biliary duct. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the movement of bile and/or gallstones in the biliary duct, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the movement of bile and/or gallstones in the biliary duct. The method can be used for restricting or stopping the movement of bile and/or gallstones in the biliary duct, or for actively moving the fluid in the biliary duct, with a low risk of injuring the biliary duct.Type: ApplicationFiled: February 6, 2012Publication date: August 16, 2012Inventor: Peter Forsell
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Patent number: 8244347Abstract: Methods and apparatus for effectuating a lasting change in a neural function of a patient, including via mechanical force on neural tissue, are disclosed. An apparatus in accordance with one embodiment includes an implantable force delivery device that is changeable between a first state in which the force delivery device applies a first mechanical force to neural tissue, and the second state in which the force delivery device applies no mechanical force or a second mechanical force less than the first mechanical force to the neural tissue, while the force delivery device is implanted. An actuator can be coupled to the force delivery device with a communication link to change the state of the force delivery device, and a controller can be operably coupled to the actuator to automatically direct the force delivery device to change repeatedly between the first and second states while the force delivery device is implanted.Type: GrantFiled: March 6, 2006Date of Patent: August 14, 2012Inventor: Andres M. Lozano
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Patent number: 8239018Abstract: An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween.Type: GrantFiled: August 25, 2010Date of Patent: August 7, 2012Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris
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Patent number: 8239044Abstract: In one embodiment, a method of electrically stimulating neural tissue of a patient, comprises: generating, by an implantable pulse generator, one or more electrical pulses; applying the one or more electrical pulses to neural tissue of a patient using one or more electrodes of one or more stimulation leads; concurrently with the generating, providing a voltage waveform or signal by the implantable pulse generator; and concurrently with the applying, electrically coupling one or more field effect electrodes of the one or more stimulation leads to the voltage waveform or signal to generate a localized electric field within tissue proximate to the one or more electrodes used to apply the one or more electrical pulses.Type: GrantFiled: December 5, 2008Date of Patent: August 7, 2012Assignee: Advanced Neuromodulation Systems, Inc.Inventor: Benjamin A. Tranchina
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Patent number: 8235966Abstract: The present invention is a method for electromanipulation of chemical species in vivo relative to a target tissue utilizing a nonconductive, conformable array base adapted to be placed coincident to the target tissue, a plurality of electrode elements projecting from the array base towards the target tissue, the electrode elements addressable individually, an electrical source coupled to the plurality of electrodes, a control means interposed between the electrical source and the plurality of electrode elements and in circuit communication therein, the control means adapted to establish an electrical potential between at least two electrodes, and a delivery means adapted to introduce chemical species to the target tissue.Type: GrantFiled: August 2, 2010Date of Patent: August 7, 2012Assignee: University of South FloridaInventors: Andrew M. Hoff, Richard Gilbert, Richard Heller, Mark J. Jaroszeski
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Publication number: 20120191149Abstract: A resuscitation system that includes at least two defibrillation electrodes configured to be applied to the exterior of the chest of a patient for delivering a defibrillation shock, a source of one or more ECG signals from the patient, a defibrillation circuit for delivering a defibrillation shock to the defibrillation electrodes, a control box that receives and processes the ECG signals to determine whether a defibrillation shock should be delivered or whether CPR should be performed, and that issues instructions to the user either to deliver a defibrillation shock or to perform CPR, wherein the determination of whether CPR should be performed and the instructions to perform CPR can occur at substantially any point during a rescue.Type: ApplicationFiled: April 3, 2012Publication date: July 26, 2012Inventor: Gary A. Freeman
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Publication number: 20120191147Abstract: A novel wearable electronic skin patch sensor device configured for the real time acquisition, processing and communicating of cardiac activity and other types of biological information within a wired or wireless network is disclosed. A system level scheme for networking the sensor device with client devices that include intelligent personal health management appliances, cellular telephones, PDAs, portable computers, personal computers, RFID Tags and servers is disclosed. The sensor device and the system enable distributed processing, archival and correlation of the biological information with biometrics, gastronomic information, user profiles and health factors that include height, weight, blood pressure and physical activity facilitating real time personal health management at any time and any place.Type: ApplicationFiled: November 30, 2004Publication date: July 26, 2012Inventors: Raman K. Rao, Sunil K. Rao, Rekha K. Rao
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Publication number: 20120191148Abstract: The Energy Field and Target Correlation System automatically correlates the characteristics of target particles and a living organism to compute the characteristics of an energy field that is applied to a living organism to activate the target particles which are bound to or consumed by invasive agents in the living organism to produce detectable effects which can be used to treat the invasive agents. The energy field must be crafted to properly control the response and localize the extent of the illumination. The System automatically selects a set of energy field characteristics, including: field type, frequency, field strength, duration, field modulation, repetition frequency, beam size, and focal point. The determined energy field characteristics then are used to activate field generators to generate the desired energy field.Type: ApplicationFiled: January 24, 2011Publication date: July 26, 2012Applicant: Actium BioSystems, LLCInventors: Daniel B. McKenna, Karl M. Frantz, Marvin A. Ross, Andrew C. Updegrave, Michael E. Susedik
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Publication number: 20120185004Abstract: An anchorage device comprising a mesh substrate coupled to an implantable medical device is disclosed, where the mesh substrate has a coating comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the mesh over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.Type: ApplicationFiled: November 10, 2011Publication date: July 19, 2012Applicant: TYRX, Inc.Inventors: William McJames, Frank Do, Satish Pulapura, Qing Ge
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Patent number: 8224439Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.Type: GrantFiled: February 1, 2010Date of Patent: July 17, 2012Assignee: Vamaris Innovations, Inc.Inventors: Jeffry B. Skiba, Lawrence A. Schneider
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Patent number: 8219186Abstract: A non-invasive system and method of diagnosing and predicting cardiac disease in a patient's heart is disclosed that comprises a microprocessor which contains a signal processor and a pattern recognition processor; detect the electrophysiological signals of the heart whereby the signals are processed to create a pattern that represents the patient's heart. The pattern may be further processed by repeatedly comparing it to patterns stored within the pattern recognition processor whereby certain coronary diseases such as myocardial ischemia in the patient's heart may be diagnosed. During each heartbeat, at least a million different electrical signals are collected and the results of test are displayed on a screen. The results may include the diagnosis, computer generated image of the patient's heart identifying areas of any cardiac disease that has been detected and/or a two dimensional non-linear waveform representing the electrophysiological signals of the patient's heart.Type: GrantFiled: March 5, 2009Date of Patent: July 10, 2012Inventor: Guangren Chen
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Publication number: 20120172764Abstract: In an embodiment, an implantable medical device includes a controller circuit, a posture sensing circuit, and a physiological sensing circuit. The controller circuit senses a change in a physiological signal as a result of a change in posture, and generates a response as a function of that change. In another embodiment, the controller circuit identifies a heart failure condition as a function of the change in the physiological signal.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Inventors: John D. Hatlestad, Imad Libbus, Aaron Lewicke
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Publication number: 20120172940Abstract: Several embodiments are provided for a modular therapeutic garment having electrodes integral with the garment and treatment permitted by such garment. The therapeutic garment can comprise a compression knit fabric material, and an array of electrodes integral with the compression knit fabric material. The compression knit fabric material can exert pressures within a range including values suitable for clinical treatment. The array of electrodes can be arranged to overlie specific portions of a subject, such as muscle groups or other body parts. Each electrode of the array of electrode can be formed of a conductive knit fabric material. The conductive knit fabric material can enclose a liquid absorptive material. A method for treating a musculoskeletal dysfunction with the therapeutic garment also is provided. The method also can be effective at improving musculoskeletal condition of healthy subjects.Type: ApplicationFiled: November 30, 2011Publication date: July 5, 2012Inventors: Terry L. Wahls, Richard Shields, Ryan David Feld
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Publication number: 20120165883Abstract: A system and method for correlating health related data for display. The system includes a medical device recording data and a display producing device which correlates the data and simultaneously displays different types of data or displays two sets of the same type of data along with the circumstances at which the two sets of data were recorded. Such displays aid a physician in prescribing and ascertaining the efficacy of cardiac therapies.Type: ApplicationFiled: March 2, 2012Publication date: June 28, 2012Inventors: James Kalgren, Rene H. Wentkowski, Jeffrey E. Stahmann
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Patent number: 8209037Abstract: An endoluminal treatment device and method includes introducing an endoluminal device into a lumen of a patient and engaging a wall of the lumen with an implant device. The implant device can be a drug delivery device or medical device.Type: GrantFiled: October 4, 2007Date of Patent: June 26, 2012Assignee: Ethicon Endo-Surgery, Inc.Inventors: Michael Laufer, Thomas Bromander, Amos Cruz
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Publication number: 20120157976Abstract: The present invention generally relates to methods, compositions and materials for treatment of and promotion of neurological functional recovery from neurological conditions including central nervous system injuries and/or diseases.Type: ApplicationFiled: December 20, 2011Publication date: June 21, 2012Inventors: Stephen Davies, Kenneth Hal Minor
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Publication number: 20120150245Abstract: A method is provided for renal neuromodulation. One step of the method includes providing an expandable support member having a cuff-like configuration and including a main body portion (MBP). The MBP includes a lumen for engaging a wall of a blood vessel including a portion of a renal vasculature. At least one electrode connected with the MBP is arranged to selectively deliver electric current to a desired location. An insulative material is attached to at least a portion of the MBP. Next, the MBP is implanted extravascularly so that the MBP is in direct contact with a portion of the renal vasculature. At least one electrode is positioned substantially adjacent a desired location where modulation of the sympathetic nervous system (SNS) is effective to alter renal function. Electric current is then delivered to the at least one electrode to effect a change in the SNS.Type: ApplicationFiled: February 22, 2012Publication date: June 14, 2012Inventors: Ali R. Rezai, Roy K. Greenberg, Milind Deogaonkar
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Publication number: 20120150244Abstract: A resuscitation system for resuscitating a patient, comprising at least two defibrillation electrodes adapted to be worn by the patient for extended periods of time, circuitry for monitoring the ECG of the patient, at least one processor configured for analyzing the ECG of the patient, and determining whether electrical therapy should be delivered to the electrodes, circuitry for providing defibrillation pulses to the defibrillation electrodes, and circuitry for providing resuscitation prompts, wherein at least the circuitry for monitoring the ECG, the processor configured for analysing the ECG, and the circuitry for providing resuscitation prompts are contained in one or more devices adapted to be worn by the patient.Type: ApplicationFiled: October 12, 2011Publication date: June 14, 2012Inventors: Gary A. Freeman, Mark Totman
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Publication number: 20120143272Abstract: Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of endogenous progenitor stem cells of the central nervous system (CNS). A therapy, such as an electrical signal or a stem cell enhancing agent, or a combination of therapies, is applied to a CNS region containing endogenous stem cells or a CNS region where the endogenous stem cells are predicted to migrate and eventually reside, or a combination thereof.Type: ApplicationFiled: December 7, 2011Publication date: June 7, 2012Applicant: MEDTRONIC, INC.Inventor: Lisa L. Shafer
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Patent number: 8195298Abstract: A method for treating a patient with a neurological or psychiatric disorder, comprising applying stimulation to at least a portion of the patient's subcaudate white matter of the subcaudate area under conditions effective to provide the patient with at least a partial relief from the neurological or psychiatric disorder. The stimulation may be electrical and/or pharmacological.Type: GrantFiled: February 6, 2009Date of Patent: June 5, 2012Inventor: Andres M Lozano
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Patent number: 8195290Abstract: Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.Type: GrantFiled: September 20, 2010Date of Patent: June 5, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Marina V. Brockway, Imad Libbus, Krzysztof Z. Siejko, Robert J. Sweeney
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Patent number: 8190253Abstract: A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.Type: GrantFiled: July 7, 2009Date of Patent: May 29, 2012Assignee: Medtronic, Inc.Inventors: Kenneth T. Heruth, Keith A. Miesel
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Publication number: 20120130440Abstract: An apparatus comprises an implantable cardiac signal sensing circuit that provides an electrical cardiac signal representative of cardiac activity of a subject, an implantable therapy circuit that delivers electrical pacing stimulation energy to a heart of a subject, and a controller circuit. The controller circuit includes a chronotropic incompetence detection circuit that initiates pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate, monitor the AV interval, initiates an increase in the pacing rate while continuing the monitoring of the AV interval, calculates a change in AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring, and indicates that the AV intervals are evidence of chronotropic incompetence when the calculated change in the AV intervals exceeds a specified threshold AV interval change value.Type: ApplicationFiled: November 7, 2011Publication date: May 24, 2012Inventors: Yinghong Yu, Donald L. Hopper, Jiang Ding, James O. Gilkerson
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Publication number: 20120123293Abstract: A motor device for bypassing or bridging an area of neurological damage, including at least one electrode having an electric mechanism for generating electric current, and a programming mechanism for programming the electrode. A biofeedback system and an artificial spinal cord. A method of stimulating muscle in a person having neurological damage, by applying electric current to nerves, bypassing or bridging an area of neurological damage, and moving the muscle in a natural manner. Methods of moving muscles of a paraplegic, reducing or eliminating pain from an individual, and treating foot drop. A therapeutic method for exercising for an individual with neurological damage. A method of generating movement of muscle and sensing that movement in a person having neurological damage. A method of generating movement of muscle using information from the brain and sensing that movement in a person having neurological damage. A method of diagnosing neurological damage.Type: ApplicationFiled: November 10, 2011Publication date: May 17, 2012Applicant: IINN, Inc.Inventors: Jawad A. Shah, Amer Iqbal, Richard H. Smith
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Publication number: 20120115827Abstract: The present invention relates to a novel 3-aminobenzamide, compound represented by the following formula which effectively inhibits vanilloid receptor subtype 1 (VR1) activity (wherein, for example, R1 is a C1-6 alkyl group which may be substituted, R2 is a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group which may be substituted, R3 is a hydrogen atom or a C1-6 alkyl group, R4 is a C1-6 alkyl group, a C1-6 alkoxy group, or a halo C1-6 alkyl group, m is an integer of 1 to 5 and P is a carbon or hetero ring) or a pharmaceutically acceptable salt thereof. The pharmaceutical composition comprising as active ingredients the 3-aminobenzamide, compound or a pharmaceutically acceptable salt thereof is useful for treating diseases involved in VR1 activity such as pain, acute pain, chronic pain, neuropathicpain, rheumatoid arthritis pain, and neuralgia.Type: ApplicationFiled: June 7, 2011Publication date: May 10, 2012Applicant: Japan Tobacco Inc.Inventors: Yoshihisa Koga, Shinji Yata, Takashi Watanabe, Takuya Matsuo, Masahiro Sakata, Wataru Kondo
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Publication number: 20120109231Abstract: The present invention includes systems, devices, and methods relating to the monitoring of the functional maturation of biological interventions effecting cardiac pacing.Type: ApplicationFiled: November 1, 2010Publication date: May 3, 2012Inventors: Vinod Sharma, Deborah A. Jaye, Daniel Sigg