Stimulating Bladder Or Gastrointestinal Tract Patents (Class 607/40)
  • Patent number: 11911614
    Abstract: The present disclosure provides a device for state-dependent pudendal nerve stimulation for bladder control in a subject and methods of making and using the same.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: February 27, 2024
    Assignee: DUKE UNIVERSITY
    Inventors: Warren M. Grill, James A. Hokanson, Christopher L. Langdale
  • Patent number: 11906556
    Abstract: Online estimation of area-level inertia can be used for frequency stability control in low-inertia power systems. This disclosure provides an area-level inertia online estimation method considering inter-area equivalent frequency dynamics. The disclosed method only needs one phasor measurement unit placed at any bus within each area. The inter-area equivalent frequency dynamics model for the multi-area power system is developed, which is employed to estimate area-level inertia under the small disturbance situation. Then, the area-level inertia estimation model boils down to a nonlinear parameter identification problem. The other boundary conditions of the disclosed method are derived by parameter identifiability.
    Type: Grant
    Filed: June 8, 2023
    Date of Patent: February 20, 2024
    Assignee: NORTH CHINA ELECTRIC POWER UNIVERSITY
    Inventors: Tianshu Bi, Cheng Wang, Jiahao Liu, Guoyi Xu
  • Patent number: 11872371
    Abstract: The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: January 16, 2024
    Assignee: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    Inventors: Theodoros Zanos, Todd Levy, Emily Battinelli, Kevin J. Tracey, Chad E. Bouton, Sangeeta Chavan, Harold Silverman
  • Patent number: 11833350
    Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed in the context of esophageal ablation. An ablation device may include a first catheter defining a longitudinal axis and a lumen therethrough. A balloon may be coupled to the first catheter. The balloon may be configured to transition between a deflated configuration and an inflated configuration. A second catheter may extend from a distal end of the first catheter lumen. A set of splines including electrodes formed on a surface of each of the splines may couple to the distal end of the first catheter lumen and a distal portion of the second catheter. The second catheter may be configured for translation along the longitudinal axis to transition the set of splines between a first configuration and a second configuration.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: December 5, 2023
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Raju Viswanathan, Gary Long, Jean-Luc Pageard
  • Patent number: 11819683
    Abstract: Systems and methods for treating a gastrointestinal condition of a patient includes minimally invasively implanting a modular stimulator system in a patient's treatment site. The modular stimulator system comprises a microstimulator module, a small power source module and a macrostimulator module that are detachably attachable to each other. For the first phase of treatment, the microstimulator module and power source are implanted with a stimulating electrode proximate a target tissue. Electrical stimulation is provided for a short period of time and treatment efficacy is evaluated through clinical results and patient reporting. If therapy is not effective, stimulation parameters can be changed and/or the implantation site can be moved. If therapy is effective, portions of the microstimulator module and/or small power source are replaced with the macrostimulator module for long term therapy of the second phase of treatment.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: November 21, 2023
    Inventors: Paul V. Goode, Virender K. Sharma, Shai Policker
  • Patent number: 11806211
    Abstract: A device for treating obesity of a patient, the device comprising: at least one operable stretching device implantable in the patient and adapted to stretch a portion of the patient's stomach wall, and an implantable control unit for automatically controlling the operable stretching device, when the control unit and stretching device are implanted, to stretch the stomach wall portion in connection with the patient eating such that satiety is created.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: November 7, 2023
    Inventor: Peter Forsell
  • Patent number: 11793980
    Abstract: An intestinal attachment device is provided that includes an ingestible housing with a chamber having disposed therein a low-profile ribbon with a head that serves as a single attachment area for an anchor sized and configured to attach to the mucosal surface of an intestine. A disposable material is also disposed within the chamber and at least partially surrounds the ribbon. An anchor is disposed within the housing and is attached to the head of the low-profile ribbon. The anchor has a constrained and a non-constrained state and is sized and configured to attach to the mucosal surface of the intestine. The anchor is at least partially surrounded by a dissolvable material.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: October 24, 2023
    Assignee: CELERO SYSTEMS, INC.
    Inventors: Benjamin D. Pless, Daniel Bacher
  • Patent number: 11779215
    Abstract: A method and system for obtaining and analyzing ECG waveforms from a patient is disclosed. Initially, a recommendation for obtaining an ECG waveform from a patient is issued, typically from a cardiologist. An ECG recording device is used to obtain ECG data from the patient. The recording device generates patient identification information, time and date information and an initial analysis that are included in a log delivered along with the ECG data to an analysis server. The analysis server generates a recommended action for the patient, which is delivered to the recording device while the patient is still present at the recording device. The recording device can then carry out the recommended action and provide the results for analysis by the cardiologist. The analysis server can utilize artificial intelligence/machine learning to generate the recommended action for the patient without having to involve the cardiologist, thereby reducing the number of visits for the treatment of the patient.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: October 10, 2023
    Assignee: GE Precision Healthcare LLC
    Inventor: Satyanarayana T
  • Patent number: 11717681
    Abstract: Systems and methods for treating gastroesophageal reflux disease (GERD) includes minimally invasively implanting a stimulating device in a patient's esophagus in the region proximate the lower esophageal sphincter (LES). The patient is provided with a questionnaire related to his disease via an online service. The questionnaire is accessed on a mobile device, such as a cell phone, or on a computer with network access. The data from the sensors and the answers from the questionnaire are analyzed together by a health care provider using the online service. The data and answers are used to program the stimulating device, via the mobile device or computer, to optimize treatment.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 8, 2023
    Inventors: Virender K. Sharma, Shai Policker
  • Patent number: 11712566
    Abstract: A method including transcutaneously measuring motility patterns, in the colon of a recipient of an implantable neuromodulator, responsive to an electrical stimulus delivered by the implantable neuromodulator, and programming the implantable neuromodulator responsive to the measured motility patterns, wherein the method comprises adjusting at least one parameter of the implantable neuromodulator that defines the electrical stimulus that the implantable neuromodulator is configured to deliver to the recipient.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: August 1, 2023
    Assignee: Alimetry Limited
    Inventors: Armen Gharibans, Gregory Brian O'Grady, Peng Du, Jonathan Christopher Erickson
  • Patent number: 11707602
    Abstract: A catheter system includes an indwelling, hollow catheter having a tip inserted into a person's bladder. The tip has an opening through which urine from the bladder passes into the catheter. A flexible reservoir extends around the person's ankle and has walls bounding an interior compartment. A flexible, elongated tube has one end connected to the catheter and an opposite end connected to the reservoir. The tube is hollow for conducting urine in the catheter through the tube into the compartment of the reservoir. One of the walls of the reservoir is a bottom wall that engages and rests on a top of the person's foot in use to resist downward movement of the reservoir as the reservoir is filled with urine. A freely manipulated drain pipe is in fluid communication with the reservoir.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: July 25, 2023
    Inventor: Leonid Shendelman
  • Patent number: 11684774
    Abstract: Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.
    Type: Grant
    Filed: July 15, 2022
    Date of Patent: June 27, 2023
    Assignee: Mainstay Medical Limited
    Inventors: Peter Andrew Crosby, Dan Sachs, Prashant Brijmohansingh Rawat, Jason Alan Shiroff, Johannes Petrus Heemels
  • Patent number: 11673000
    Abstract: An implantable device for implantation in a human body or animal body. The device includes an energy source, an energy storage device, and an electronics unit. Further, an actuator is coupled with the energy storage device and it is configured to emit electromagnetic waves by discharging the energy storage device.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: June 13, 2023
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Thomas Doerr, Ingo Weiss
  • Patent number: 11633601
    Abstract: Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: April 25, 2023
    Assignee: Galvani Bioelectronics Limited
    Inventors: Margarita J. Vervoordeldonk, Robert Coatney, Cindy Cleypool
  • Patent number: 11590351
    Abstract: Spinal cord stimulation (SCS) system having a recharging system with self alignment, a system for mapping current fields using a completely wireless system, multiple independent electrode stimulation outsource, and control through software on a Smartphone/mobile device and tablet hardware during trial and permanent implants. SCS system can include multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) providing concurrent, but unique stimulation fields. SCS system can include a replenishable power source, rechargeable using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery, can charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. A bi-directional telemetry link informs the patient or clinician the status of the system, including the state of charge of the IPG battery.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: February 28, 2023
    Assignee: CIRTEC MEDICAL CORPORATION
    Inventors: Saif Khalil, Raghavendra Angara, Miles Curtis, Christopher Biele, Daniel Fellmeth
  • Patent number: 11577077
    Abstract: Systems and methods for the treatment of gastroesophageal reflux disease (GERD) include at least one electrically stimulating electrode coupled to a pulse generator. Individuals with GERD are treated by implanting a stimulation device within and/or proximate the patient's lower esophageal sphincter, gastric fundus, or other nearby gastrointestinal structures and applying electrical stimulation to the patient's lower esophageal sphincter and/or fundus, in accordance with certain predefined protocols. Electrical stimulation provided by the disclosed systems results in an increase in the length of the high pressure zone of the LES and/or modulation of the receptive relaxation response of the fundus to decrease gastric pressure, creating a longer barrier to the reflux of gastric contents or increasing functional lower esophageal pressure respectively, thereby treating GERD.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: February 14, 2023
    Inventors: Virender K. Sharma, Shai Policker
  • Patent number: 11582856
    Abstract: An electrotechnical core for generating a cold atmospheric pressure or low-pressure plasma for the treatment of human, animal, or technical surfaces. The core has a side facing the surface and a side facing away from the surface and comprises the following layers, starting from the side facing the surface: a first insulation layer, a first electrode structure with a first contact between the first electrode structure and a power supply unit, a second insulation layer to galvanically isolate the first electrode structure and a second electrode structure from one another, wherein the second electrode structure is driven during operation by a voltage signal sufficient to ignite a plasma, a third insulation layer to galvanically isolate the second electrode structure from a third electrode structure, wherein the third electrode structure grounds the third electrode structure during operation.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: February 14, 2023
    Assignee: COLDPLASMATECH GMBH
    Inventors: Martin Polak, Robert Banaschik, Axel Kühle, Tobias Güra, Carsten Mahrenholz
  • Patent number: 11565095
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents (TA) within the GI tract and in particular to an antrum wall (AW). Particular embodiments provide a swallowable device (SD) such as a capsule for delivering drugs or other TA into the AW. The SD may contain a pressure sensitive component or assembly which triggers release and insertion of a therapeutic agent preparation (TAP) comprising at least one TA into the AW in response to external pressure, such as pressure applied to the swallowable capsule or other SD by antrum contractions. Particular embodiments of the SD may be shaped so that they self-align within an antrum to properly orient before injection of the TAP into the AW. Embodiments of the invention are particularly useful for orally delivering drugs or other TAs which are degraded within the GI tract and require parenteral injection.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: January 31, 2023
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 11517750
    Abstract: The present specification discloses devices and methodologies for the treatment of GERD. Individuals with GERD may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow, have improved energy storage requirements, enable improved LES function while concurrently delivering additional health benefits, and enable improved LES function post stimulation termination.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: December 6, 2022
    Inventors: Virender K. Sharma, Edy Sofer, Paul V. Goode, Bevil Hogg, Shai Policker, Matthew Joseph Gani, Jay Miazga, Kaila Raby
  • Patent number: 11511111
    Abstract: A gastric electric stimulation (GES) system is disclosed which includes a processing system, and at least one of a left vagus nerve sensor (L/R Sensors) and a right vagus nerve sensor coupled to the processing system, the processing system is configured to receive a model which statistically correlates sensed compound nerve action potential (CNAP) parameters measured from at least one of left and right vagus nerves of subjects within a population to feedback surveys of the subjects corresponding to a plurality of gastric symptoms and symptom parameters, receive one or more gastric symptoms of a subject outside of the population (Subjectout), determine CNAP parameters that correspond to the gastric symptoms with least severity (CNAPmin), measure CNAP activity of the Subjectout from the L/R sensors while modifying GES parameters for the Subjectout, select the GES parameters that corresponds to the CNAPmin (GESout), and output the GESout.
    Type: Grant
    Filed: December 20, 2020
    Date of Patent: November 29, 2022
    Assignee: Purdue Research Foundation
    Inventor: Matthew P. Ward
  • Patent number: 11511105
    Abstract: The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject's cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: November 29, 2022
    Assignee: MUSC Foundation for Research Development
    Inventors: Bashar Badran, Mark George, Doe Jenkins, Daniel Cook
  • Patent number: 11504534
    Abstract: The present disclosure is directed to a system and method for selectively and reversibly modulating targeted neural and non-neural tissue of a nervous system for the treatment of pain. An electrical stimulation is delivered to the treatment site that selectively and reversibly modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting the perception of pain while preserving other sensory and motor function, and proprioception.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: November 22, 2022
    Assignee: Avent, Inc.
    Inventors: Eric A. Schepis, David M. Page, Natalia Alexeeva, Lee C. Burnes
  • Patent number: 11504024
    Abstract: A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: November 22, 2022
    Assignee: Vibrant Ltd.
    Inventors: Lior Ben-Tsur, Shai Molnar, Roni Shabat
  • Patent number: 11484717
    Abstract: There is provided a method for controlling the movement of bile and/or gall stones in the biliary duct. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the movement of bile and/or gallstones in the biliary duct, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the movement of bile and/or gallstones in the biliary duct. The method can be used for restricting or stopping the movement of bile and/or gallstones in the biliary duct, or for actively moving the fluid in the biliary duct, with a low risk of injuring the biliary duct.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: November 1, 2022
    Inventor: Peter Forsell
  • Patent number: 11471681
    Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: October 18, 2022
    Assignee: SetPoint Medical Corporation
    Inventors: Ralph J. Zitnik, Michael A. Faltys, Jacob A. Levine, Jesse M. Simon
  • Patent number: 11464986
    Abstract: The present invention relates to a preoperative test method, to an implantation system (20) and to an implantation method for implanting a neuroprosthesis in the area of the pubic bone (31), wherein implantation is ultimately simplified and made more effective directly or indirectly by the subject-matters of the invention.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: October 11, 2022
    Inventor: Marc Possover
  • Patent number: 11426586
    Abstract: An integrated circuit includes: a radio-frequency (RF) to direct current (DC) rectifying circuit coupled to one or more antenna on an implantable wirelessly powered device, the rectifying circuit configured to: rectify an input RF signal received at the one or more antennas and from an external controller through electric radiative coupling; and extract DC electric power and configuration data from the input RF signal; a logic control circuit connected to the rectifying circuit and a driving circuit, the logic control circuit configured to: generate a current for the driving circuit solely using the extracted DC electrical power; in accordance with the extracted configuration data, set polarity state information for each electrode; and a driving circuit coupled to one or more electrode, the driving circuit comprising current mirrors and being configured to: steer, to each electrode and via the current mirrors, a stimulating current solely from the generated current.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: August 30, 2022
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Chad David Andresen, Bertan Bakkaloglu
  • Patent number: 11395911
    Abstract: Disclosed is a skin treatment needle by which energy is supplied into skin tissue to increase the speed of skin regeneration. The skin treatment needle includes a needle body that is formed of a conductive material and inserted into skin, starting from a front end thereof. A region of an outer circumferential surface of the needle body includes a conductive portion which is a region inducing an electric field different from those formed at other portions of the needle body, and the conductive portion includes a plurality of corrugations to cause an electric field formed via the conductive portion to have a uniform distribution without being biased and concentrated to a side.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: July 26, 2022
    Assignee: AGNES MEDICAL CO., LTD.
    Inventors: Gunyoung Ahn, Wooseok Koh
  • Patent number: 11395919
    Abstract: Systems, devices and methods are provided for transcutaneously delivering energy impulses to bodily tissues for therapeutic purposes, such as for enhancing the body's bone healing process in spinal fusion patients. A therapeutic stimulator system comprises a housing for an energy source and a signal generator. The system further includes one or more electrodes coupled to the signal generator. A processor is coupled to the housing and configured to determine usage levels of the signal generator and/or motion data of the housing. The system may include a mobile device that allows the patient to input user status data, such as pain levels, and compare the user status data with the usage levels and/or the motion data, thereby improving patient compliance with a prescribed therapy regimen.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: July 26, 2022
    Assignee: THERAGEN, INC.
    Inventors: Richard H. Pearce, Jon Christopher McAuliffe
  • Patent number: 11369310
    Abstract: A method of predicting successful treatment of disorders of bodily tissue includes obtaining, with a device, energy signal data from the bodily tissue of a patient. The obtained energy signal data is analyzed in a controller to determine an activity score value associated with the bodily tissue. The activity score value is compared, in the controller, to a threshold value, with the threshold value being based on energy signal data from the same bodily tissue of normal, disease free patients. Based on the comparison, a probability of success of a particular therapy in treating the bodily tissue is determined. A system for performing the method is also disclosed.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: June 28, 2022
    Inventor: Mark D. Noar
  • Patent number: 11347316
    Abstract: Devices, systems, and techniques for mitigating error from gesture input are disclosed. A system may receive an indication of a first gesture input, determine that the first gesture input is an indicator gesture input, and, responsive to the determination that the first gesture input is the indicator gesture input, enter a gesture control mode during which the system is configured to control one or more actions related to a medical procedure. Only during the gesture control mode, the system may receive an indication of a second gesture input associated with the medical procedure and, responsive to receiving the indication of the second gesture input, control, based on the second gesture input, at least a portion of the medical procedure. Additionally, or alternatively, the system may employ other error mitigation techniques for gesture input related to medical procedures.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: May 31, 2022
    Assignee: Medtronic, Inc.
    Inventors: Steven M. Goetz, Pedram Afshar
  • Patent number: 11324947
    Abstract: A first value of an electrical stimulation parameter of an electrical stimulation therapy that resulted in a first physiological response for a patient is identified. The electrical stimulation therapy is delivered at least in part through a lead that is implanted inside the patient. Based on the first value, a limit of a second value of the electrical stimulation parameter that should result in a second physiological response for the patient is determined. An actual second value of the electrical stimulation parameter that actually resulted in the second physiological response for the patient is identified. Based on a comparison of the limit of the second value and the actual second value, an implantation of the lead is evaluated.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: May 10, 2022
    Assignee: Cirtec Medical Corporation
    Inventors: Norbert Kaula, Yohannes Iyassu
  • Patent number: 11291828
    Abstract: A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 5, 2022
    Assignee: NEUROSTIM SOLUTIONS LLC
    Inventors: Graham H. Creasey, Hoo-Min Toong
  • Patent number: 11247050
    Abstract: A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudenal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: February 15, 2022
    Assignee: InCube Labs, LLC
    Inventor: Mir Imran
  • Patent number: 11207518
    Abstract: Described herein are methods for treating a subject suffering from or at risk for a condition mediated by an inflammatory cytokine cascade, by electrically or mechanically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: December 28, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Jared M. Huston, Kevin J. Tracey
  • Patent number: 11198005
    Abstract: A nerve activity blocking system (100) includes a blocking electrode (102) configured to generate a blocking electrical signal that blocks, at least in part, an action potential propagating through a nerve system of a body. using a low frequency alternating current. The blocking electrical signal prevents propagation of the action potential by overriding another electrical signal controlling an organ of the body.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 14, 2021
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Ken Yoshida, Michael Ryne Horn
  • Patent number: 11166650
    Abstract: A medical device and method for determining a dose of insulin to be administered for glycemic control is provided, wherein the dose is stepwise adapted. The method includes determining a blood glucose value, receiving glycemic event information in respect to a predetermined glycemic event, wherein the predetermined glycemic event occurred within a predetermined time interval, receiving a previously adapted dose value stored in a storage unit, and setting an alert based on at least the blood glucose value, the glycemic event information and the previously adapted dose, wherein the alert indicates that the blood glucose value and the predetermined glycemic event are not in a specified relation to the previously adapted dose value.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: November 9, 2021
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Andrew Tubb
  • Patent number: 11129990
    Abstract: An electrical stimulation system includes a stimulator having at least one electrode and a power supply. The electrode is connectable to the power supply, and the power supply delivers electrical stimulation energy in the form of a capacitive discharge voltage through the stimulator and electrode to tissue proximate a target anatomy to induce an observable response in the target anatomy during a medical procedure.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: September 28, 2021
    Assignee: Allotrope Medical, LLC
    Inventors: Jeffrey Paul Castleberry, Nishant Verma, Albert Yung-Hsiang Huang
  • Patent number: 11126270
    Abstract: Devices, systems, and techniques for mitigating error from gesture input are disclosed. A system may receive an indication of a first gesture input, determine that the first gesture input is an indicator gesture input, and, responsive to the determination that the first gesture input is the indicator gesture input, enter a gesture control mode during which the system is configured to control one or more actions related to a medical procedure. Only during the gesture control mode, the system may receive an indication of a second gesture input associated with the medical procedure and, responsive to receiving the indication of the second gesture input, control, based on the second gesture input, at least a portion of the medical procedure. Additionally, or alternatively, the system may employ other error mitigation techniques for gesture input related to medical procedures.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: September 21, 2021
    Assignee: Medtronic, Inc.
    Inventors: Steven M. Goetz, Pedram Afshar
  • Patent number: 11090491
    Abstract: A medical apparatus for a patient comprises an implantable system. The implantable system comprises a first implantable device comprising: at least one implantable functional element configured to deliver stimulation energy to tissue of the patient; and an implantable controller configured to provide a stimulation waveform to the at least one implantable functional element, the stimulation waveform comprising one or more stimulation parameters. The apparatus is configured to randomly vary at least one of the one or more stimulation parameters. Methods of providing stimulation energy with randomly varying stimulation parameters are also provided.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 17, 2021
    Assignee: Nalu Medical, Inc.
    Inventors: Lakshmi Narayan Mishra, James C. Makous, Lee Fason Hartley, Daniel M. Pivonka, J. Christopher Flaherty
  • Patent number: 11058876
    Abstract: The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: July 13, 2021
    Assignee: ENDOSTIM (ABC), LLC
    Inventors: Virender K. Sharma, Matt Joseph Gani, Paul V. Goode, Bevil Hogg, Jay Miazga, Shai Policker, Kaila Raby
  • Patent number: 11052248
    Abstract: The present specification discloses devices and methodologies for the treatment of achalasia. Individuals with achalasia are treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 6, 2021
    Assignee: ENDOSTIM (ABC), LLC
    Inventors: Virender K. Sharma, Shai Policker, Bevil Hogg
  • Patent number: 11040196
    Abstract: Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: June 22, 2021
    Assignees: Cilag GmbH International, The General Hospital Corporation
    Inventors: Jason L. Harris, Nicholas Stylopoulos, Lee M. Kaplan, Tamara C. Baynham, Taylor W. Aronhalt
  • Patent number: 10994134
    Abstract: A stimulator device for controlling waste storage for a subject, having one electrode placed in proximity to a portion of each of the right and left pudendal nerves, which contains efferent fibers that, when stimulated, produce contraction of the urethral or anal sphincter. The stimulator device having a pulse generator connected to electrodes, bilaterally, to provide stimulation for each electrode to stimulate pudendal efferent axons. The pulse generator adapted to provide a first type of stimulation to cause waste to be stored within the subject. The pulse generator adapted to provide a second type of stimulation, different from the first type of stimulation, to allow waste to be voided from the subject by blocking nerve impulses that accompany sphincter dyssynergia. An input device to allow an end user to select the first type of stimulation, the second type of stimulation, or no stimulation. Variations of the concept are disclosed.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: May 4, 2021
    Assignee: Dignify Therapeutics, LLC
    Inventor: Karl Bruce Thor
  • Patent number: 10946185
    Abstract: A topical nerve stimulator patch and system are provided including a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: March 16, 2021
    Assignee: Neurostim Solutions, LLC
    Inventors: Graham H. Creasey, Hoo-Min D. Toong
  • Patent number: 10933240
    Abstract: Methods for electrical modulation of inflammation or serum TNF levels in a subject.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: March 2, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Adam M. Kressel, Valentin A. Pavlov, Sangeeta S. Chavan, Kevin J. Tracey
  • Patent number: 10918871
    Abstract: Systems and methods are provided for neuro stimulation. In one implementation, a system is provided that includes a stimulator introduced into tissue at a target location and a central controller that communicates wirelessly with the stimulator. The stimulator includes a power system that receives wireless energy transmission, and an electrode system that transmits an electrical pulse for stimulating the target location. The central controller includes a power system that wirelessly delivers power to the stimulator, a communication system that wirelessly communicates with the stimulator, and a processing system that controls the power system and the communication system. The central controller may instruct the stimulator to transmit one or more electrical pulses to the target location to affect an endocrine function (e.g., affect the glucose level of a patient).
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: February 16, 2021
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Anil Kumar Ram Rakhyani, Peng Cong, Stephen O'Driscoll, Sean Korhummel, Travis Deyle
  • Patent number: 10905580
    Abstract: A device for treating obesity of a patient, the device comprising: at least one operable stretching device implantable in the patient and adapted to stretch a portion of the patient's stomach wall, and an implantable control unit for automatically controlling the operable stretching device, when the control unit and stretching device are implanted, to stretch the stomach wall portion in connection with the patient eating such that satiety is created.
    Type: Grant
    Filed: April 30, 2018
    Date of Patent: February 2, 2021
    Inventor: Peter Forsell
  • Patent number: 10881320
    Abstract: According to one aspect, an implantable medical device may include an anchor assembly configured to anchor the medical device to a body lumen. The implantable medical device may also include a capsule. The capsule may include a pH sensor. The pH sensor may be configured to measure a pH of contents within the body lumen. The capsule may also include a power source, a controller, and an impedance sensor. The impedance sensor may be configured to measure an impedance within the body lumen.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: January 5, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: George W. Duval, Paul J. Smith, Michael Y. Ko
  • Patent number: 10835229
    Abstract: A balloon dissector includes a cannula, an expandable bladder, and a cord. The cannula defines a lumen between proximal and distal ends. The expandable bladder is configured to expand when fluid is injected into the lumen and includes an inner surface, a proximal base, and a retainer. The proximal base is selectively coupleable to the distal end of the cannula in a sealing relationship. The retainer is positioned on the inner surface of the expandable bladder. The cord includes a first end, a second end, and a central portion. The one end of the cord extends from the proximal end of the cannula. The cord extends through the lumen of the cannula and through the retainer of the bladder returning into the lumen. The cord configured to draw the expandable bladder into the lumen after the expandable bladder is expanded.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: November 17, 2020
    Assignee: Covidien LP
    Inventor: Jessica Gould