Hypertension Treating Patents (Class 607/44)
  • Patent number: 10485658
    Abstract: Systems and methods for controlling blood pressure via electrical stimulation of the heart are disclosed. Embodiments may include at least two different stimulation patterns, each configured to reduce blood pressure to a different degree, and may alternate between stimulation patterns based on the need of a patient, for example, alternating between day and night or between periods of strenuous and light activity. Some embodiments may take advantage of a slow baroreflex response that occurs after treatment is stopped, suspending treatment for extended periods, and then resuming treatment before blood pressure levels reach pretreatment values. Embodiments may control blood pressure by controlling atrial pressure and atrial stretch.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: November 26, 2019
    Assignee: BackBeat Medical, Inc.
    Inventors: Yuval Mika, Darren Sherman, Robert S. Schwartz, Robert A. Van Tassel, Daniel Burkhoff
  • Patent number: 10420606
    Abstract: Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: September 24, 2019
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Denise Zarins, Hanson Gifford, III, Mark Deem, Nicolas Zadno, Benjamin J. Clark, Andrew Wu, Kenneth J. Michlitsch
  • Patent number: 10314739
    Abstract: A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: June 11, 2019
    Assignee: MyoScience, Inc.
    Inventors: John Allison, Richard Radnovich, Jason Reynolds
  • Patent number: 10220212
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: March 5, 2019
    Assignee: LivaNova USA, Inc.
    Inventors: Imad Libbus, Bruce H. Kenknight, Badri Amurthur
  • Patent number: 10194979
    Abstract: Methods for treating preventing or decreasing the likelihood of a human patient developing hypertension and associated systems and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods for therapeutic renal neuromodulation that partially inhibit sympathetic neural activity in renal nerves proximate a renal blood vessel of a human patient. This reduction in sympathetic neural activity is expected to therapeutically treat one or more conditions associated with hypertension or prehypertension of the patient. Renal sympathetic nerve activity can be modulated, for example, using an intravascularly positioned catheter carrying a neuromodulation assembly, e.g., a neuromodulation assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the renal nerves.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: February 5, 2019
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Sandeep S. Brar, Minglei Liu, Manuela Negoita
  • Patent number: 10064674
    Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: September 4, 2018
    Assignee: Metavention, Inc.
    Inventors: Bobak Robert Azamian, Scott Bradley Vafai
  • Patent number: 9814395
    Abstract: Implanted electrodes can be used to deliver electrical stimulation signals to areas near blood vessels, nerves, or other internal body locations. In an example, an electrode can be implanted in a cervical location and can be used to measure dimensional changes in an artery using impedance plethysmography. Measured artery dimensional changes can be used to determine one or more physiological parameters associated with a patient's health status, such as pulse transit time, relative pulse pressure, or aterial compliance, among others. These parameters can be used to monitor a patient health status or to modulate a patient's therapy, among other uses. In some examples, an electrode configured to deliver an electrostimulation signal to nerve tissue can be used to provide non-neurostimulating electrical stimulation plethysmography signals near a blood vessel.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: November 14, 2017
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jeffrey E. Stahmann, David J. Ternes, Barun Maskara, Shantha Arcot-Krishnamurthy, Juan Gabriel Hincapie Ordonez, Scott Vanderlinde
  • Patent number: 9744351
    Abstract: The present invention is related to an implantable medical device for treating breathing disorders and cardiac disorders by delivering stimulation energy to the phrenic nerve, hypoglossal nerves and cardiac muscle tissues.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: August 29, 2017
    Assignee: Respicardia, Inc.
    Inventors: Mark Gelfand, Howard R. Levin
  • Patent number: 9731132
    Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: August 15, 2017
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Mark Deem, Denise Zarins, Douglas Sutton, Hanson Gifford, III, Howard R. Levin, Mark Gelfand, Benjamin J. Clark
  • Patent number: 9687376
    Abstract: A knee brace for continual electro-acupuncture stimulation system comprises a first circuit having a first circuit having a first electrode configured to electrically coupled to acupuncture point “Heting (S 156)” and a second electrode configured to electrically coupled to acupuncture point “Bladder 40”, a second circuit having a third electrode configured to electrically coupled to acupuncture point “Spleen 10” and a fourth electrode configured to electrically coupled to acupuncture point “Hsiyen (S 145)”, and a third circuit having a fifth electrode configured to electrically coupled to acupuncture point “Stomach 34” and a sixth electrode configured to electrically coupled to acupuncture point “Stomach 35”. The first, third, and fifth electrodes are connected to a polarity of voltage, and the second, fourth, and sixth electrodes are connected to an opposite polarity of voltage, such that electric currents flow in a body of a patient to achieve analgesia, cartilage repair and regeneration in the knee joint.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: June 27, 2017
    Inventor: Y. King Liu
  • Patent number: 9656086
    Abstract: Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: May 23, 2017
    Assignee: BackBeat Medical, Inc.
    Inventors: Yuval Mika, Darren Sherman, Robert S. Schwartz, Robert A. Van Tassel, Daniel Burkhoff
  • Patent number: 9656079
    Abstract: A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: May 23, 2017
    Assignee: Medtronic, Inc.
    Inventors: Michael R. S. Hill, Gary W. King, Thomas J. Mullen, Xiaohong Zhou
  • Patent number: 9649156
    Abstract: A first spacing structure is provided at a distal end of a first catheter. The first spacing structure is configured to position at least one arterial electrode at a predefined distance away from a wall of the renal artery. A second spacing structure is provided at the distal end of the first catheter or at a distal end of a second catheter. The second spacing structure is configured to position at least one aortal electrode at a predefined distance away from a wall of the aorta. The arterial and aortal electrodes are operable as a bipolar electrode arrangement. The first and second spacing structures respectively maintain the arterial and aortal electrodes at a predefined distance away from the renal artery and aortal walls while electrical energy sufficient to ablate perivascular nerve tissue adjacent the renal artery and aortal walls is delivered by the bipolar electrode arrangement.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: May 16, 2017
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Mark L. Jenson, Scott R. Smith
  • Patent number: 9636174
    Abstract: Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: May 2, 2017
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Denise Zarins, Hanson Gifford, III, Mark Deem, Douglas Sutton, Howard R. Levin, Mark Gelfand
  • Patent number: 9629742
    Abstract: A knee brace for continual electro-acupuncture stimulation system comprises: a first electrode configured to electrically coupled to acupuncture point Heting “(S 156)”; a second electrode configured to electrically coupled to acupuncture point “Spleen 10 ”; a third electrode configured to electrically coupled to acupuncture point “Stomach 34 ”; a fourth electrode configured to electrically coupled to acupuncture point “Hsiyen (S 145)”; a fifth electrode configured to electrically coupled to acupuncture point “Stomach 35 ”; a sixth electrode configured to electrically coupled to acupuncture point “Bladder 40 ”. The first, second, and third electrodes are connected to a polarity of voltage, and the fourth, fifth, and sixth electrodes are connected to an opposite polarity of voltage, such that electric currents flow in a body of a patient to achieve analgesia, cartilage repair and regeneration in the knee joint.
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: April 25, 2017
    Inventor: Y. King Liu
  • Patent number: 9533153
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: January 3, 2017
    Assignee: CYBERONICS, INC.
    Inventors: Imad Libbus, Bruce H. KenKnight, Badri Amurthur
  • Patent number: 9511228
    Abstract: A method for managing hypertension through renal nerve denervation and vagus nerve stimulation is provided. Renal nerves are disrupted to inhibit a sympathetic nervous system. Thereafter, an implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: December 6, 2016
    Assignee: CYBERONICS, INC.
    Inventors: Badri Amurthur, Imad Libbus, Bruce H. KenKnight
  • Patent number: 9463066
    Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: October 11, 2016
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Mark Deem, Denise Zarins, Douglas Sutton, Hanson Gifford, III, Howard R. Levin, Mark Gelfand, Benjamin J. Clark
  • Patent number: 9457189
    Abstract: An implantable baroreflex activation device administers a special electrotherapy program that causes the device to apply electrotherapy to limit a rate of change of blood pressure increase associated with a blood pressure surge event such as a morning blood pressure surge (MBPS).
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: October 4, 2016
    Assignee: CVRx, Inc.
    Inventor: Martin A. Rossing
  • Patent number: 9452290
    Abstract: An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. Operating modes of the pulse generator are stored. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. A restorative dose of the electrical therapeutic stimulation is delivered to prevent initiation of or disrupt tachyarrhythmia through periodic electrical pulses delivered at higher intensity than the maintenance dose.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: September 27, 2016
    Assignee: CYBERONICS, INC.
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. Kenknight
  • Patent number: 9427579
    Abstract: A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: August 30, 2016
    Assignee: PACESETTER, INC.
    Inventors: Eric S. Fain, Martin Cholette, Gary R. Dulak, Gene A. Bornzin, John W. Poore
  • Patent number: 9421366
    Abstract: The present invention generally relates to patterned intensity modulation of neural tissue. Certain embodiments provide a method of treating medical conditions by providing an electrode and modulating stimulation parameters delivered by the electrode. The stimulation parameters that are modulated relate to stimulation intensity and are varied according to a stimulation input parameter or time. The stimulation input parameter can be a choice of an individual waveform (i.e. ? or psi), which may be varied for each pulse.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: August 23, 2016
    Assignee: Case Western Reserve University
    Inventors: Dustin Tyler, Daniel Tan, Matthew Schiefer
  • Patent number: 9403007
    Abstract: Some embodiments, by way of example, provide a system, comprising a posture change detector configured to detect a posture transition indicative of an increased risk of syncope, and a neural stimulator configured to deliver a neural stimulation therapy. The neural stimulator may include a syncope avoidance module configured to respond to a detected posture transition by temporarily overriding the neural stimulation therapy to ameliorate the risk of increased syncope.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: August 2, 2016
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Eric A. Mokelke, Shibaji Shome, Guy Alvarez, Harlan Bos, Kenneth Martin Stein, John D. Hatlestad
  • Patent number: 9399136
    Abstract: An implantable medical device is powered by a battery to deliver one or more therapies including at least one non-life-sustaining therapy such as neural stimulation for enhancing quality of life of a patient. When the battery approaches its end of life, the implantable medical device reduces power consumption of the neural stimulation (e.g., intensity of the neural stimulation) for extending the remaining battery life while maintaining a certain amount of therapeutic benefits for the patient. In one embodiment, the intensity of the neural stimulation is reduced in a tiered manner. In one embodiment in which the implantable medical device also delivers at least one life-sustaining cardiac stimulation therapy, the neural stimulation is disabled or adjusted to reduce its power consumption (e.g., intensity) while the intensity of the cardiac stimulation therapy is maintained when the battery is near its end of life.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: July 26, 2016
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jason J. Hamann, Scott Vanderlinde, David J. Ternes
  • Patent number: 9386927
    Abstract: A method for monitoring blood pressure includes sensing and storing sympathetic nerve activity data of a patient via a recording lead of an implantable medical device. Changes in sympathetic nerve activity from the nerve activity data are determined. Corresponding changes in blood pressure are determined from the changes in sympathetic nerve activity. An alert signal and/or modification of therapy can be provided.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: July 12, 2016
    Assignee: Medtronic, Inc.
    Inventor: Daniel R. Kaiser
  • Patent number: 9364284
    Abstract: A method of making a spacer cage is disclosed. The method may include providing a tube having an outer diameter, a first second, a second section and a middle section having a first end connected to the first section and a second end connected to the second section, cutting the middle section to form strut elements of the spacer cage and cutting a plurality of longitudinal slits in the first and second sections to allow radial expansion of the first and second sections, expanding the tube using a mandrel, heat setting the tube while on the mandrel, and subsequent the heat setting, removing the first and second sections from the tube.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: June 14, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Joel N. Groff, Scott R. Smith
  • Patent number: 9289255
    Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: March 22, 2016
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Mark E. Deem, Hanson Gifford, III, Denise Zarins, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R. Levin
  • Patent number: 9237984
    Abstract: Disclosed herein are intravascular systems and methods for modulating the activation of neural activity using shock wave devices. In one embodiment, the system is used to treat the nerves in the renal plexus. In a second embodiment, the system is used to treat the baroreceptors in the carotid sinus. In a preferred embodiment, the shock wave generator is in the form of electrodes mounted within an inflatable balloon.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: January 19, 2016
    Assignee: SHOCKWAVE MEDICAL, INC.
    Inventors: Daniel Hawkins, John M. Adams
  • Patent number: 9125567
    Abstract: Apparatus is provided for reducing hypertension of a subject. A selective circumferential pressure applicator (60) includes at least two surfaces (61) that increase baroreceptor activity of the subject, by applying pressure to an artery (20) of the subject at two or more respective non-contiguous regions around the circumference of the artery, at a longitudinal site of the artery, such that between the non-contiguous regions, at the longitudinal site (a) there is at least one region (22) of the artery that is more relaxed than in the absence of the device, and (b) there is at least one region (21) of the artery that is more tense than in the absence of the device. A joint (63) couples the surfaces to each other. For at least a portion of the subject's cardiac cycle, the joint does not to contact the subject's artery. Other applications are also provided.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: September 8, 2015
    Assignee: VASCULAR DYNAMICS, INC.
    Inventors: Yossi Gross, Itzik Avneri, Omry Ben Ezra, Ori Weisberg, Raanan Gefen
  • Patent number: 9126044
    Abstract: In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: September 8, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Andrew P. Kramer, Jason J. Hamann
  • Patent number: 9114123
    Abstract: According to some embodiments, a method of treating a subject having diabetes or symptoms associated with diabetes is provided. The method includes delivering a neuromodulation catheter within a vessel (e.g., hepatic artery) having surrounding nerves that innervate the liver (e.g., sympathetic nerves of the hepatic plexus). The method may also include modulating (e.g., disrupting, ablating, stimulating) the nerves by mechanical compression, energy delivery, or fluid delivery.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: August 25, 2015
    Assignee: Metavention, Inc.
    Inventors: Bobak Robert Azamian, Scott Bradley Vafai
  • Patent number: 9114262
    Abstract: An implantable device (11) for evaluating autonomic cardiovascular drive in a patient (10) suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead (13) includes helical electrodes (14) configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins (28) electrically connected to the helical electrodes (14). A neurostimulator (12) includes an electrical receptacle (25) into which the connector pins (28) are securely and electrically coupled. The neurostimulator (12) also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes (14) in alternating cycles of stimuli application and stimuli inhibition (90) that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator (12) includes a recordable memory (29) storing a baseline heart rate.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: August 25, 2015
    Assignee: CYBERONICS, INC.
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight
  • Patent number: 9095711
    Abstract: A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: August 4, 2015
    Assignee: EnteroMedics Inc.
    Inventors: Katherine S. Tweden, Richard R. Wilson, Mark B. Knudson, Dennis Dong-Won Kim, Deepak Bhole
  • Publication number: 20150148862
    Abstract: The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
  • Publication number: 20150142011
    Abstract: Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.
    Type: Application
    Filed: June 30, 2014
    Publication date: May 21, 2015
    Inventors: Adam Cates, Eric Lovett, Loren Murney, Kip Ludwig, Paul Pignato, Brian Soltis
  • Patent number: 9026215
    Abstract: An implantable baroreflex activation device administers a special electrotherapy program that causes the device to apply electrotherapy to limit a rate of change of blood pressure increase associated with a blood pressure surge event such as a morning blood pressure surge (MBPS).
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: May 5, 2015
    Assignee: CVRx, Inc.
    Inventor: Martin A. Rossing
  • Patent number: 9022948
    Abstract: System and method for locating and identifying nerves innervating the wall of arteries such as the renal artery are disclosed. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether a dose of energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of the energy delivered to the nerve. The method includes at least the steps to evaluate a change in physiological parameters after a dose of energy is delivered to an arterial wall; and to determine the type of nerve that the energy was directed to (none, sympathetic or parasympathetic) based on the results of the evaluation. The system includes at least a device for delivering a dose of energy to the wall of an artery; sensors for detecting physiological signals from a subject; and indicators to display the results obtained using the said method.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: May 5, 2015
    Assignee: Symap Holding Limited
    Inventor: Jie Wang
  • Patent number: 9020595
    Abstract: An embodiment of a baroreflex stimulator comprises a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator to modulate the baroreflex stimulation signal based on a circadian rhythm template.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: April 28, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventor: Imad Libbus
  • Publication number: 20150112402
    Abstract: An implant unit according to some embodiments may include a flexible carrier, at least one pair of modulation electrodes on the flexible carrier, and at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes. The at least one pair of modulation electrodes and the at least one circuit may be configured for implantation through derma on an underside of a subject's chin and for location proximate to terminal fibers of the medial branch of the subject's hypoglossal nerve, such that an electric field extending from the at least one pair of modulation electrodes can modulate one or more of the terminal fibers of the medial branch of the hypoglossal nerve.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 23, 2015
    Inventor: Adi Mashiach
  • Publication number: 20150112359
    Abstract: In order to treat hypertension, an implantable receiving device is connected to implantable leads which are adapted to deliver electrical energy to the carotid body or bodies of the patient. The receiving device is arranged to receive electoral energy from an external generator. The device thus enables the delivery of electrical currents which modify the function of neural tissue, particularly where repeated treatments are needed or where positioning of a percutaneous needle is difficult.
    Type: Application
    Filed: May 24, 2013
    Publication date: April 23, 2015
    Inventor: Ivor Gillbe
  • Patent number: 9014809
    Abstract: An exemplary embodiment includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: April 21, 2015
    Assignee: Pacesetter, Inc.
    Inventors: Brian J. Wenzel, Taraneh Ghaffari Farazi
  • Patent number: 9014821
    Abstract: This invention provides a method of using a catheter for mapping parasympathetic or sympathetic renal nerve for treatment of disease caused by systemic renal nerve hyperactivity, wherein the catheter comprises a shaft having a proximal end configured to be connected to an energy source, and a distal end (catheter tip) which is in the form of a single helix, double helix or multiple prongs having one or more electrodes.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: April 21, 2015
    Assignee: Symap Holding Limited
    Inventor: Jie Wang
  • Patent number: 9002446
    Abstract: An exemplary embodiment includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: April 7, 2015
    Assignee: Pacesetter, Inc.
    Inventors: Brian J. Wenzel, Taraneh Ghaffari Farazi
  • Patent number: 9002457
    Abstract: An implantable medical device is powered by a battery to deliver one or more therapies including at least one non-life-sustaining therapy such as neural stimulation for enhancing quality of life of a patient. When the battery approaches its end of life, the implantable medical device reduces power consumption of the neural stimulation (e.g., intensity of the neural stimulation) for extending the remaining battery life while maintaining a certain amount of therapeutic benefits for the patient. In one embodiment, the intensity of the neural stimulation is reduced in a tiered manner. In one embodiment in which the implantable medical device also delivers at least one life-sustaining cardiac stimulation therapy, the neural stimulation is disabled or adjusted to reduce its power consumption (e.g., intensity) while the intensity of the cardiac stimulation therapy is maintained when the battery is near its end of life.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: April 7, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jason J. Hamann, Scott Vanderlinde, David J. Ternes
  • Patent number: 8996105
    Abstract: An active implantable medical device for vagal stimulation with optimization of ventricular filling is disclosed. The device delivers stimulation pulses to the vagal nerve of the patient with an adjustable energy level. The device includes a hemodynamic sensor for measuring hemodynamic parameters of the patient's cardiac cycles and delivering a timing parameter representative of the ventricular filling time. The energy level of the vagal stimulation pulses is adjusted dynamically and repeatedly over several cardiac cycles. The energy level is varied during successive cardiac correlative changes in the filling time (FT1, FT2) are assessed (46), and the energy level is set to a level that maximizes the ventricular filling time.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: March 31, 2015
    Assignee: Sorin CRM SAS
    Inventor: Marcel Limousin
  • Publication number: 20150080481
    Abstract: Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 19, 2015
    Inventors: Denise Zarins, Hanson Gifford, III, Mark Deem, Douglas Sutton, Howard R. Levin, Mark Gelfand
  • Patent number: 8972015
    Abstract: An intravascular electrode system includes an expandable anchor and a flexible substrate which carries at least one electrode. The anchor is positioned in a blood vessel and expanded to an expanded position to bias the electrode in contact with the vessel wall. The flexible substrate may be longitudinally withdrawn from its position between the anchor and the vessel wall without removing the anchor from the blood vessel. A second flexible substrate may be longitudinally inserted into position between the anchor and vessel wall as replacement for the first substrate.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: March 3, 2015
    Assignee: Interventional Autonomics Corporation
    Inventors: Richard S. Stack, Michael S. Williams, Daniel W. Fifer, Richard A. Glenn, Geoffrey A Orth, Lynn Elliott, Colleen Stack
  • Publication number: 20150057313
    Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
    Type: Application
    Filed: March 8, 2013
    Publication date: February 26, 2015
    Inventors: Michael J. Joyner, Bruce D. Johnson, Thomas P. Olson
  • Patent number: 8965512
    Abstract: System and methods for adhering a patch of stimulation electrode(s) to blood vessels to stimulate a target site on the blood vessel are described. In various embodiments, the system includes an adhesion patch and at least one electrode. The adhesion patch includes a passive adhesion mechanism that may produce an adhesive force sufficiently strong to adhere the adhesion patch to the exterior of the blood vessel and to operationally position the at least one electrode for use in electrically stimulating a target site of the blood vessel. The adhesion patch may also include a release mechanism that is configured for a user to disengage the patch from the exterior of the blood vessel without significant trauma to the blood vessel. After being released, the adhesion patch may be re-adhered to a different target site of the blood vessel and stimulate the different target site.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: February 24, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Allan C. Shuros, Ismail Guler, Richard Charles Gunderson, Joel P. Grover, Eric A. Mokelke, Adam David Grovender
  • Patent number: RE45718
    Abstract: Systems and methods for blocking nerve impulses use an implanted electrode located on or around a nerve. A specific waveform is used that causes the nerve membrane to become incapable of transmitting an action potential. The membrane is only affected underneath the electrode, and the effect is immediately and completely reversible. The waveform has a low amplitude and can be charge balanced, with a high likelihood of being safe to the nerve for chronic conditions. It is possible to selectively block larger (motor) nerve fibers within a mixed nerve, while allowing sensory information to travel through unaffected nerve fibers.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: October 6, 2015
    Assignee: BOSTON SCIENTIFIC CORPORATION
    Inventors: Kevin L. Kilgore, Warren M. Grill, Cameron C. McIntyre, John T. Mortimer