Abstract: A method and system for providing patient indications to an entity, the method comprising: for each of a set of patients: by way of an application executing at a mobile computing device, accessing a sensor system and a log of use of a communication application executing on the mobile computing device; receiving a survey response dataset; generating a behavioral dataset, derived from the sensor system and the log of use; generating a predictive model derived from at least one of the survey response dataset and the behavioral dataset; generating comparisons of outputs of blocks of the method to threshold conditions; producing a set of indications corresponding to the set of patients, derived from generation of, for each of the set of patients, an indication in response to the comparisons; and transmitting a portion of the set of indications to the entity according to a resource constraint of the entity.

Abstract: Palatal expander apparatuses for expanding a patient's palate (“palatal expanders”) and methods of using and making them. The palatal expanders may include tooth engagement regions connected by a palatal region that is configured to apply force between the tooth engagement regions. At least a portion of the palatal region may be configured to have a clearance from the patient's mid-palatal region when the palatal expander is worn by the patient. The clearance between the palatal region and the patient's palate may decrease from the patient's mid-palatal region laterally toward the tooth engagement regions.

Abstract: A method and system for identifying a treatment plan identifies a description of a sequential game. The game is associated with treatment of a medical condition by a course of treatment or drug design. The description may include one or more possible treatment actions that a treater can take to treat the medical condition, and one or more possible medical condition actions that the medical condition can take. The system will identify a model for the sequential game, wherein the model is a large game associated with a large state space. The system may solve the model to generate a treatment plan for the medical condition, wherein the treatment plan includes a set of possible treatment actions. To accommodate the large state space, the system may divide processing steps so that at least some of the model solving is done by a graphics processing unit, while performing other functions via a central processing unit.

Abstract: The present disclosure relates to methods, devices, kits and systems for enhancing the efficacy and longevity of denervation procedures.

Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.

Abstract: A method and apparatus for transdermally providing electrical current to a region of a user's head at high impedance conditions, while maintaining low voltage levels.

Abstract: A system and method for scoring movement disorder symptoms comprises a movement measurement data acquisition system and processing comprising kinematic feature extraction and an algorithm trained using Unified Parkinson's Disease Rating Scale (UPDRS) and Movement Disorder Society UPDRS (MDS-UPDRS) scores from skilled clinicians. The movement data acquisition system, or “movement measuring apparatus,” may comprise sensors such as accelerometers or gyroscopes or may utilize motion capture and/or machine vision technology or various other methods to measure tremor, bradykinesia, gait and balance disturbances, dyskinesia, or other movement disorders in a subject afflicted with Parkinson's disease, essential tremor or the like. The method outputs, and system displays, a score that uses and inclusive 0-4 scale that correlates to the UPDRS and MDS-UPDRS, or to a particular component of the movement disorder such as speed, amplitude or rhythm, but has greater resolution and lower variability.

Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.

Abstract: The methods and systems herein generally relate to generating stimulation waveforms for a therapy of a neurostimulation (NS) device in a patient. The methods and systems receive a target stimulation waveform from a user interface, calculate a timing resolution of the target stimulation waveform, determine target amplitude resolutions of the target stimulation waveform, identify whether a mathematical relationship exists between the target amplitude resolutions, and automatically designate one of a first, second, or third generator circuits based on at least one of the timing resolution, the amplitude, or the mathematical relationship. The systems and methods further transmit the target stimulation waveform and an activation instruction for the designated one of the first, second, or third generator circuits along the communication link to a NS device. The NS device includes the first, second, and third generator circuits configured to generate different first, second, and third types of stimulation waveforms.

Abstract: Methods, systems, and products provide interfaces between intrahost networks and interhost networks within biological hosts. Neuroregional translations are performed to route communications to and from the biological hosts. Bioregional translations may also be performed to route communications to and from the biological hosts.

Abstract: An implantable medical device is capable of delivering therapeutic output to a patient. A controller, programmable by a medical professional, is operatively coupled to the implantable medical device to, in part, program the therapeutic output to be delivered to the patient. The controller has an interface allowing the medical professional to graphically select an amount of the therapeutic output to be delivered to the patient in at least one of a series of discrete timer intervals. The graphic selection may be aided by the use of a light pen or other pointing device to sketch the infusion pattern. Computer programs using algorithms may be utilized to translate the information inputted through the light pen into an infusion program.

Abstract: The present invention relates generally to a method and apparatus for determining one or more cumulative effects of an application of transcranial magnetic stimulation to the brain of a subject, as well as a method and apparatus of representing same. According to an aspect of certain embodiments of the invention there is provided a method for determining one or more cumulative effects of an application of transcranial stimulation to one or more locations in a brain of a subject comprising the steps of applying multiple transcranial magnetic stimulation pulses to the brain, determining a dose of each of said stimulation pulses, measuring a physical response of the user and determining or approximating an accumulation of said response of said brain for each of said one or more locations in the brain of said subject.

Abstract: A method of displaying pain or stimulation experienced by a patient includes providing a graphical user interface configured to receive an input from a user and display a visual output to the user. A first map and a second map are concurrently displayed via the graphical user interface. The first map and the second map are each a pain map or a stimulation map. The pain map represents a body area of the patient experiencing pain. The stimulation map represents a body area of the patient experiencing electrical stimulation. A virtual control mechanism is displayed via the graphical user interface. Through the graphical user interface, an engagement of the virtual control mechanism is detected. In response to the engagement of the virtual control mechanism, respective visual emphases of the first map and the second map are simultaneously adjusted.

Abstract: A system and method for tuning the parameters of a therapeutic medical device comprises a movement measurement data acquisition system capable of wireless transmission; processing comprising kinematic feature extraction, a scoring algorithm trained using scores from expert clinicians, a therapeutic device parameter setting adjustment suggestion algorithm preferably trained using the parameter setting adjustment judgments of expert clinicians; and a display and/or means of updating the parameter settings of the treatment device. The invention facilitates the treatment of movement disorders including Parkinson's disease, essential tremor and the like by optimizing deep brain stimulation (DBS) parameter settings, eliminating as much as possible motor symptoms and reducing time and costs of surgical and outpatient procedures and improving patient outcomes.

Abstract: A system for trigeminal nerve stimulation includes a storage medium, a pulse generator in communication with the storage medium, a power source coupled to the pulse generator, and at least one electrode communicatively coupled to the pulse generator. The pulse generator includes a microcontroller which executes instructions from the storage medium and the microcontroller is configured to perform at least one of the following operations: produce electrical pulses having defined characteristics, record a log of use and anomalous events, restrict use to a specified individual, interface with electrodes, provide a signal to the specified individual indicating operational conditions and trouble conditions, and provide a signal to the specified individual indicating an end of a treatment period.

Abstract: Weight loss methods and systems are described. In one embodiment, behavior modification program data indicating participation in a weight loss behavior modification program is recorded. Drug therapy program data indicating drug fulfillment of a weight loss drug therapy program drug is recorded, in which the drug fulfillment of the weight loss drug therapy program drug occurs after participation in the weight loss behavior modification program. Whether a weight loss surgical program criterion has been met is determined based on analysis of the behavior modification program data and the drug therapy program data. The weight loss surgical program criterion is based on the participation in the weight loss behavior modification program and the drug fulfillment of the weight loss drug therapy program drug. A surgical weight loss program approval is generated based on a determination that the surgical weight loss program criterion has been met. Additional methods and systems are disclosed.

Abstract: A programmer allows a clinician to identify combinations of electrodes from within an electrode set implanted in a patient that enable delivery of desirable neurostimulation therapy by an implantable medical device. The programmer executes an electrode combination search algorithm to select combinations of electrodes to test in a non-random order. According to algorithms consistent with the invention, the programmer may first identify a position of a first cathode for subsequent combinations, and then select electrodes from the set to test with the first cathode as anodes or additional cathodes based on the proximity of the electrodes to the first cathode. The programmer may store information for each combination tested, and the information may facilitate the identification of desirable electrode combinations by the clinician. The clinician may create neurostimulation therapy programs that include identified desirable program combinations.

Abstract: This invention uses dysgeusia-inducing neurostimulation to selectively modify a person's consumption of a selected type of nutrient or food. This invention includes a nutrient-specific consumption sensor that detects when a person consumes a particular type of nutrient or food and a Dysgeusia-Inducing Neurostimulation Device (DIND) that temporarily modifies a person's sense of taste when the person consumes that nutrient or food. This invention can make unhealthy food taste less appealing and make healthy food taste more appealing. Such selective taste modification can improve a person's nutritional quality and help them to manage their weight.

Abstract: An enuresis electroconditioner pertains to the field of medical appliances and includes a humidity sensor (2) connected to an electric circuit which is activated in the presence of a liquid. When the liquid is detected, an electric current with a frequency of 50 Hz is generated. A qualified person must calibrate the amperage of the apparatus (1), adapting it to the sensibility of each person who, when receiving the electric impulse, contracts the perineal muscles, occluding the urethra and by a reflexive action inhibiting the contraction of the bladder and preventing urine loss.

Abstract: A method for the treatment of eating disorders by nerve tissue stimulation and infusion techniques to one or more areas of the brain affecting hunger and satiety; palatability and aversion; hedonism; reward/addiction behavior; mood; anxiety; depression, taste and smell. The invention also comprises methods for the treatment of disorders of these individual behaviors and in particular, disorders of taste and/or smell.

Abstract: Method and systems modulating eating behavior comprising (i) generating at least one confounding neuro-electrical signal that is adapted to modulate the sense of taste in the body, (ii) generating at least one confounding neuro-electrical signal that is adapted to modulate the sense of smell in the body, and (ii) transmitting at least one of the confounding neuro-electrical signals to a subject to modulate the subject's sense of taste or smell. In a preferred embodiment, both confounding neuro-electrical signals are transmitted to the subject to modulate the subject's sense of taste and smell.

Abstract: Nerves that carry taste sensations to the brain are stimulated in order to diminish (or, depending on the application, augment) the pleasure ordinarily associated with consumption behavior to be modified.

Abstract: A method for modulating eating behavior comprising (i) generating at least one confounding neuro-electrical signal that is adapted to modulate the sense of taste in the body, (ii) generating at least one confounding neuro-electrical signal that is adapted to modulate the sense of smell in the body, and (ii) transmitting at least one of the confounding neuro-electrical signals to a subject to modulate the subject's sense of taste or smell. In a preferred embodiment, both confounding neuro-electrical signals are transmitted to the subject to modulate the subject's sense of taste and smell.

Abstract: A system and method for providing processable data associated with anatomical images may provide a user interface including a pivot and stem tool via which to align multiple images, a flashlight bar for viewing portions of an overlaid image, and/or user-movable markers for establishing a location of one or more anatomical landmarks with regions of one or more images.

Abstract: The present invention provides methods, devices, and systems for restoring or improving nervous system function of a subject. Provided is a method involving: (i) providing an operant conditioning protocol effective to produce targeted neural plasticity (TNP) in a primary targeted central nervous system (CNS) pathway of a subject; and (ii) administering the operant conditioning protocol to the subject to elicit TNP in the primary targeted CNS pathway and to elicit generalized neural plasticity (GNP) in one or more other CNS pathway. The elicitation of the GNP in the one or more other CNS pathway serves to restore or improve a nervous system function of the subject. Provided is a device comprising a nerve stimulation-electromyographic recording component and a controller for operating the nerve stimulation-electromyographic recording component in accordance with an operant conditioning protocol.

Abstract: A method for preventing obesity related to infection by an adipogenic adenovirus includes obtaining a sample from a person, assaying the sample to determine whether the person has been previously infected with an adipogenic adenovirus, and if the person has not been previously infected, providing the person with at least one sensor positioned to detect when a person's hand approaches a predetermined distance from the person's face. By warning the person of undesired hand-to-face contacts, the person is able to reduce the incidence of obesity related infections. Other embodiments are directed to a kit for preventing obesity caused by infection with an adipogenic, adenovirus, such kit including a container for assaying an agent indicating the presence of antibodies to Ad-36, and a sensor positioned on an item selected from the group consisting of one of a hat, a writing instrument, eye glasses, a belt, sunglasses, a bra, a shirt, and a tie.

Abstract: A method for preventing obesity related to infection by an adipogenic adenovirus includes assaying a sample from a person to determine whether the person has been previously infected with an adipogenic adenovirus, and if the person has not been previously infected, providing the person with at least one sensor positioned to detect when a person's hand approaches a predetermined distance from the person's face. By warning the person of undesired hand-to-face contacts, the person is able to reduce the incidence of obesity related infections. Other embodiments are directed to a kit for preventing obesity caused by infection with an adipogenic adenovirus, such kit including a container for assaying an agent indicating the presence of antibodies to Ad-36, and a sensor positioned on an item selected from the group consisting of one of a hat, a writing instrument, eye glasses, a belt, sunglasses, a bra, a shirt, and a tie.

Abstract: A sensory data integration system for integrating sensory data generated by a first sensory substitution device and sensory data generated by a second sensory substitution device. The system includes a processor configured to generate an orientation signal indicative of a difference between a subject's orientation and an acceptable orientation. The orientation signal is based on the sensory data generated by the first sensory substitution device and the sensory data generated by the second sensory substitution device.

Abstract: Alternative stimuli, i.e., stimuli other than the constant amplitude stimuli used in prior fitting schemes, are used to set the parameters of a hearing prosthesis, such as a cochlear implant system. The use of such alternative stimuli allows the entire fitting process to be completed in a very short time period, and generally eliminates the need for secondary adjustments. In one preferred embodiment, the alternative stimuli comprise white noise that is internally generated within the speech processor.

Abstract: The cranial electrostimulation devices described herein are suitable for use in detoxification from and amelioration of the symptoms of acute and chronic withdrawal from simultaneous multiple addictive substances by transcutaneous electric nerve stimulation. A plurality of time-division multiplexed analog waveforms is applied to the mastoid process of a person in need thereof, thereby treating symptoms of withdrawal from addictive substances. The invention also provides a protocol for encoding a plurality of different waveforms combined sequentially or simultaneously, as well as an improved cranial electrostimulation apparatus having a stable output waveform signal over the useful service life of the power supply, e.g., the battery.

Abstract: Addiction treatment, specifically smoking cessation, can be effectively treated utilizing stimulation of low resistance skin locations by employing a combination of an electrical current and a laser beam. In a preferred stimulation treatment, pulsed stimulation is used, stimulating skin locations in the ear and nose areas. The present stimulation treatment is simple and cost effective, lasting about 10-20 minutes per treatment session, with an average of 1 to 2 repeated treatment sessions per person. The present stimulation treatment is proven to be effective in assisting in smoking cessation, showing high percentage of long term smoking abstinence in just one treatment session.

Abstract: Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.

Abstract: A method for reducing an individual's weight through hunger control is provided, wherein predetermined biologically active hunger control points and/or areas on the skin are stimulated utilizing removably attached point stimulation elements (PSEs) (e.g., spherules, etc.), in accordance with a predefined configurable cyclical treatment schedule. Maintenance procedures are also performed by the individual, after a predetermined amount of treatment cycles, to maintain weight reduction benefits gained during the treatments. Additional optional features of the inventive hunger control method include application of at least one of: a dietary plan, a vitamin and chronologically selected herb plan, behavioral modification, and an physical activity protocol.

Abstract: A method for personalized patient controlled neurostimulation is disclosed. The method generally includes steps (A) to (D). Step (A) may obtain (i) physical data of an individual and (ii) one or more manual inputs from the individual. Step (B) may generate compare data in a processor circuit by comparing the physical data with profile data of the individual. Step (C) may generate customized data by processing the one or more manual inputs and the compared data using a set of rules. The rules are generally (i) reprogrammable and (ii) govern generation of a nerve stimulation signal having predetermined control characteristics applicable to the individual. Step (D) may control the neurostimulation of the individual with the nerve stimulation signal based on the customized data.

Abstract: Systems, devices and methods for triaging health-related data, such as significant health-related events associated with health-related parameters, are disclosed. One aspect is a method for use in managing a patient's health within a patient management system. In various embodiments of the method, a number of predetermined events are accessed. The events are related to the patient's health and are identified by the patient management system. Each of the predetermined events are classified according to severity using a color-code system. In various embodiments, a red event is an imminent life threatening event, a yellow event is a serious health-related condition that is not imminently life threatening, and a green event is an event that is neither an imminent life threatening event nor a serious health-related condition. Other aspects and embodiments are provided herein.

Abstract: Methods, systems and devices for monitoring the health and energy expenditure of a living body, treating patients with an eating disorder or treating obese patients are described. The methods, systems and devices described may also be applicable to any treatment in which presenting feedback regarding patients' eating and exercise habits is desired. The present invention provides for treating a patient by collecting ingestion and exercise information about the patient from implanted sensors and communicating the collected information to the patient and/or to their health care provider(s). In some embodiments, stimulation of the patient's stomach is also provided to reduce caloric intake.

Abstract: A method of stimulating an auditory nerve to produce a percept in response to a detected sound signal. At least one characteristic of the sound signal is identified, and a stimulation mode is selected based on the identified characteristic. The selected stimulation mode is then used for stimulating the auditory nerve to convey the sound signal to the prosthesis recipient. Multiple characteristics of the detected sound signal may be assigned distinct stimulation modes.

Abstract: A body-worn device for a fast healing of incontinence by building up the necessary durable behavioral conditioning, which provides the brain with the necessary proper control over the respective sphincters. The device is based on two different nerve mechanisms: a first electrical pulse stops the release of bodily wastes by a simple local reflex, arousing simultaneously the brain and preparing it to respond to a second, behavioral conditioning causing electric pulse, which follows within two seconds (i.e. still during the phasic period of the cortical learning process), strong enough to cause an unpleasant sensation, which the brain connects with the just begun incontinent release of bodily waste and acquires after only a few applications as a durable adversive behavioral conditioning. This shortens the healing period from many months to only a few days. The device is easily adjustable to the individual sensitivity of the involuntarily wetting or soiling person.

Abstract: Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.

Abstract: Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.

Abstract: The invention refers to a device comprising a generator unit for generating stimulation signals and a stimulation unit connected to the generator unit, wherein the stimulation unit is designed to stimulate nerve cells in the nucleus accumbens and/or in the amygdaloid nucleus and/or in the fasciculus medialis telencephali and/or in pathways made of dopaminergic areas of the mesencephalon leading to the nucleus accumbens or the amygdaloid nucleus and/or in fiber bundles linking the nucleus accumbens and the amygdaloid nucleus using the stimulation signals.

Abstract: The cranial electrostimulation devices described herein are suitable for use in detoxification from and amelioration of the symptoms of acute and chronic withdrawal from simultaneous multiple addictive substances by transcutaneous electric nerve stimulation. A plurality of time-division multiplexed analog waveforms is applied to the mastoid process of a person in need thereof, thereby treating symptoms of withdrawal from addictive substances. The invention also provides a protocol for encoding a plurality of different waveforms combined sequentially or simultaneously, as well as an improved cranial electrostimulation apparatus having a stable output waveform signal over the useful service life of the power supply, e.g., the battery.

Abstract: Methods which are useful to aid in smoking cessation. The methods generally comprise applying an electrical current to the subject in the vicinity of two or more acupuncture points selected from acupuncture points in or on the arms and hands of the subject. Suitable points include the Hegu acupuncture point (LI-4), a point on the opposite side of the hand to the Hegu acupuncture point, the Wai guan acupuncture point (SJ-5), and the Nei guan acupuncture point (PC-6).

Abstract: A fixation device for holding stimulating electrodes in electrical contact with the wall of a portion of the gastrointestinal tract is provided. The fixation device includes an expandable member that fixes the electrodes in electrical contact with the gastrointestinal tract wall.

Abstract: The invention relates to a device for transdermal stimulation of a nerve of the human body, which device comprises at least one stimulation electrode and at least one reference electrode for transdermal nerve stimulation, the at least one stimulation electrode and the at least one reference electrode being connected to a control unit and being able to be supplied with an electrical current from the latter, and the at least one stimulation electrode and the at least one reference electrode being arranged in or on a housing which is designed to be fitted on or in the human ear. The invention further relates to a method for the transdermal stimulation of a nerve of the human body in particular of a part of the vagus nerve by applying an electrical stimulus via at least one stimulation electrode and at least one reference electrode, at least one of which is placed in contact with the skin surface of the inner face of the Tragus of the human ear.

Abstract: A method for the treatment of obesity or other disorders by electrical activation or inhibition of the sympathetic nervous system is disclosed. This activation or inhibition can be accomplished by stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an electrode. This nerve activation can result in reduced food intake and increased energy expenditure.

Abstract: A system for accessing the brain of a subject to record and/or stimulate brain stares thereof. The system includes control means, first accessing means having a plurality of contact surfaces configured to operatively connect the control means to the brain of the subject to provide three-dimensional stimulation thereof; second accessing means having a plurality of contact surfaces to operatively connect the control means to the brain of the subject to provide access thereto for the purposes of obtaining three-dimensional recordings of the brain electrical activity of the subject; and a waveform bank containing a plurality of stimulating waveforms.

Abstract: A device for minimizing the absorption of pathogens collected on a person's hands by contact between the hand and the face of said person, includes a barrier placed in the crook of the elbow that limits the flexion of the elbow as the hand approaches the face. In an alternate embodiment of the invention, a proximity sensor is positioned on a part of the person's body to sense and warn the person that a hand is about to touch the face. An audio or visual warning signal or a mechanical or electrical stimulation may be triggered by the output of the sensor. A method is also provided for progressively weaning the person from reliance on said devices.

Abstract: Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to at least treat or prevent obesity and/or other eating disorders, as well as drug, nicotine and alcohol addiction, uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.

Abstract: A programmer allows a clinician to identify combinations of electrodes from within an electrode set implanted in a patient that enable delivery of desirable neurostimulation therapy by an implantable medical device. The programmer executes an electrode combination search algorithm to select combinations of electrodes to test in a non-random order. According to algorithms consistent with the invention, the programmer may first identify a position of a first cathode for subsequent combinations, and then select electrodes from the set to test with the first cathode as anodes or additional cathodes based on the proximity of the electrodes to the first cathode. The programmer may store information for each combination tested, and the information may facilitate the identification of desirable electrode combinations by the clinician. The clinician may create neurostimulation therapy programs that include identified desirable program combinations.