Abstract: Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.

Abstract: A photoplethysmograph device includes a light source for illuminating a target object. A modulator drives the light source such that the output intensity varies as a function of a modulation signal at a modulation frequency. A detector receives light from the target object and generates an electrical output as a function of the intensity of received light. A demodulator with a local oscillator receives the detector output and produces a demodulated output, insensitive to any phase difference between the modulation signal and the oscillator, indicative of blood volume as a function of time and/or blood composition. A number of demodulators may be provided to derive signals from multiple light sources of different wavelengths, or from an array of detectors. The plethysmograph may operate in a transmission mode or a reflectance mode. When in a reflectance mode, the device may use the green part of the optical spectrum and may use polarising filters.

Abstract: We report a method for optimizing the therapeutic efficacy of evoked responses elicited by one or more electrical impulses delivered to a neural structure, comprising: comparing a test evoked response to an evoked response elicited by therapeutically efficacious electrical stimulation; adjusting at least one parameter of the electrical impulses in response to a determination that said test evoked response is not similar to the therapeutic evoked response; determining that the test evoked response resembles the therapeutic evoked response after performing at least one of said adjustments; and saving to memory at least one adjusted parameter that increased the similarity between the test evoked response and the therapeutic evoked response. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: The present invention relates to a non-invasive device and method for treating and improving dysfunction or disorders associated with pelvic floor. In one advantageous form, the non-invasive device comprising a generator configured to generate a current with a predetermined intensity of milliampere at a desirable frequency; at least one electrical stimulation applicator comprising a probe unit configured to transmit the current to a target body surface of vulvar tissues and/or pelvic floor muscle for application of an electrical stimulation; wherein the probe unit comprises a negative electrode and at least one positive electrode and the probe unit is shaped for positioning on the target body surface of the vulvar tissues and/or the pelvic floor muscle.

Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.

Abstract: Devices, systems and methods are disclosed for treating bronchial constriction related to asthma, anaphylaxis, chronic obstructive pulmonary disease (COPD), exercise-induced bronchospasm and post-operative bronchospasm. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that activate neural pathways to reduce the release of acetycholine from airway-related vagal preganglionic neurons within the brain of the patient. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to produce the bronchodilation.

Abstract: A method comprises applying a first open-loop electrical signal to a neural structure at a first rate. The method also comprises applying a closed-loop electrical signal to the neural structure in response to an event detection, thus causing an overall rate at which electrical stimulation is applied to the neural structure to exceed the first rate. The method further comprises applying a second open-loop electrical signal to a neural structure at a second rate that is lower than the first rate, thus causing the overall rate to be reduced to the first rate.

Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.

Abstract: A device for stimulation via electric and magnetic fields is provided. The autonomic/vegetative nervous system can be controlled by signals in the frequency ranges of 0.05 to 0.15 Hz and 0.15 to 0.30 Hz, respectively. By addition of characteristic sinusoidal oscillations between the head and a peripheral area with the corresponding low-frequency sympathetic or parasympathetic control frequency as base oscillation and with application-typical EEG frequencies and higher-frequency sinusoidal oscillations in the range of ca. 250 to 1500 Hz, characteristic stimulation programs are established. These are applied by field applicators in the upper body area and in the lower body. The associated mat applicators distribute field energy. The field applicator is equipped with a combination of a magnetic-field-generating coil arrangement and an electrode arrangement generating the electric field. The electrode generating the electric field can at the same time be designed as a magnetic-field-generating coil.

Abstract: A medial treatment device for treating at least first and second medical conditions is provided, as well as a method for using the same. The medical treatment device includes a stimulation device for treating the first medical condition with electrical stimulation, and an implantable mesh adapted for implantation within the patient to treat the second medical condition. The implantable mesh has a plurality of incorporated electrically conductive elements adapted to conduct electrical stimulation from the stimulation device to a position closer to a predetermined body part the stimulation of which at least partially treats the first medical condition.

Abstract: A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.

Abstract: A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.

Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.

Abstract: Methods and devices for delivering electrical stimulation to the sympathetic nervous system in response to the onset of eating. In some methods, swallowing is detected which then initiates a dose of stimulation which can vary in intensity, frequency, or both over the dose length. In some methods, the dose length is between about one quarter hour and one hour. The dose frequency may increase, hold steady, then decrease over the dose duration so as to mimic the response of the gut stretch and nutrient receptors to receiving food. The dose can drive biomarkers indicative of eating, for example glucagon, glucose, FFA or glycerol to at least about half of their normal post eating levels and then stop so as to retain stimulation effectiveness for subsequent doses and to prolong battery life.

Abstract: A device and method is provided for transdermally stimulating selected body parts of a mammal. The device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating a first predetermined body part, a second waveform generator adapted to generate a carrier waveform having a second frequency capable of passing through tissue of the mammal, and a third waveform generator adapted to generate a third waveform having a third frequency different from and out of phase with that of the first waveform, and capable of stimulating a second predetermined body part.

Abstract: A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and/or direct current pulses at or near the second site. Time-varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be promotion of micturition or defecation and the undesired side effect may be sphincter contraction.

Abstract: A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and/or direct current pulses at or near the second site. Time-varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be defibrillation of the patient's atria or defibrillation of the patient's ventricles, and the undesired side effect may be pain.

Abstract: A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.

Abstract: An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode from a channel is positioned in electrical contact with a tissue of the motor control region of the brain. A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.

Abstract: A method and apparatus for transdermal drug delivery to be provided to a patient's skin, includes performing a dermabrasion treatment of the patient's skin so as to lower a skin impedance to below a first value. It also includes providing at least one burst of electrical pulses to the patient's skin that has been dermabrasion treated, wherein each pulses in the at least one burst of electrical pulses is stabilized with respect to a current amount.

Abstract: A transcutaneous electrical nerve stimulation device and method using a microcurrent with a carrier signal and a square wave form for promoting cell repair and/or healing. It has been found that applying particular wave forms of direct current with a carrier wave signal with specified intervals promotes cell healing especially in treatment of macular degeneration. This method and nerve stimulation device is packaged to require no input from a user and a user must only apply the electrodes to the correct part of the body and start the preprogrammed sequence of electrical currents. The method involves applying bursts of direct current at higher frequencies for shorter periods of time followed by lower frequency bursts of electrical current for longer periods of time.

Abstract: An alterphasic inverting stimulation strategy for use with a multichannel cochlear implant system consumes less power than similar strategies, yet provides better sound quality. The alterphasic inverting strategy is a strategy wherein stimulation pulses are strictly sequential, and wherein the timing and polarity of the channels is chosen such that positive and negative pulses are alternating in time in accordance with a defined pattern that staggers application of the pulses spatially across all the channels and inverts the polarity of pulses that are near each other either spatially or in time.

Abstract: A series of defibrillation impulses and device for generating them in which the impulses are constituted by a wave with at least two phases of which successive phases of opposite polarity are cut or chopped at a higher frequency than the frequency of the successive phases.

Abstract: The present invention has for its object impulses or series of defibrillation impulses and device for generating them. Impulses or series of defibrillation impulses, characterized in that they are constituted by a wave with at least two phases of which successive phases of opposite polarity are cut or chopped at a higher frequency than the frequency of said successive phases.

Abstract: An apparatus for blocking the electric activity of an area of tissue, comprises circuitry (S) for creating a long non-excitatory electric signal between at least two points (R1, R2) located in the vicinity of a muscle.

Abstract: A method for treating cellulite is provided involving deep heating of the cellulite afflicted areas on the body. A preferred method of deep heating is by applying electromagnetic waves in a pulsed manner.

Abstract: A combination soft body tissue stimulator and heating device including a thin, flat, molded flexible plastic pad, one side of which defines a working surface. The molded pad has a plurality or an array of spaced separate conductive areas each having an exposed conductive surface which is generally coplanar with the working surface. When the device is properly installed, each conductive area makes electrical contact with, and receives support from, a separate disposable double-sided flexible adhesive electrode attached to the skin over the soft tissue. The array of electrodes adhesively attached to the skin is generally aligned with the array of conductive areas of the pad so that only the adhesive attachment between the conductive areas and the electrodes is required to hold the device in place against the skin.

Abstract: A system for tissue-impedance matched pulsed radio frequency (PRF) electrotherapy includes a power supply, an excitation board for generating PRF signals of a selectable frequency, the board having an input from the power supply. The system also includes a power amplifier for signals from the excitation board. Included is a subsystem for controlling pulse width duration, pulse burst repetition rate, and amplitude of the PRF signals, the controlling system having an input from the power supply. Further provided is a subsystem for continually comparing the amplitude of the PRF signals outputted from the amplifier to a reference value, this including a feedback circuit responsive to difference information between the compared signals and the reference value, the difference information inputted to the controlling subsystem for adjustment of the amplitude and impedance of the PRF signals from the excitation board, the comparing system including an output of power and impedance compensated PRF signals.

Abstract: An improved method and apparatus for pulsed magnetic induction by creating a plasma, supplying energy to excite said plasma to oscillate, and applying said the resulting oscillations to a patient or biological matter.

Abstract: Medical athermapeutic apparatus employing pulsed electromagnetic fields includes solid state regulator and power amplifier circuits and simplified applicator which result in reduced size, cost and power consumption for the device.