Pulse Signal Patents (Class 607/72)
  • Patent number: 11623093
    Abstract: Neuromodulation is used to enhance left ventricular relaxation and/or left ventricular contractility, during contemporaneous use of a mechanical circulatory support device to increase cardiac output or aid in unloading the heart. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: April 11, 2023
    Assignee: NuXcel Limited
    Inventors: Michael Cuchiara, Stephen C. Masson
  • Patent number: 11577082
    Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: February 14, 2023
    Assignees: Galvani Bioelectronics Limited, GlaxoSmithKline Intellectual Property Development Limited, Université de Nice Sophia-Antipolis, Centre Nationale de La Recherche Scientifique
    Inventors: Philippe Blancou, Nicolas Glaichenhaus, Arun Sridhar
  • Patent number: 11571154
    Abstract: An IoT device and system improves on prior approaches to tracking and analyzing symptoms and behavior of special needs individuals. The IoT device may include one or more buttons that can be pressed or held for an extended time by the user. Button presses and duration may be registered in a remote computer as being associated to a symptom or behavior. Patterns may be registered based on a sequence of the button presses and duration. Triggered button events may be collected and transmitted to a host server/network for re-transmission to support team members. In some embodiments, a machine learning module may analyze the collected data for patterns and/or deviations of behavior, which may be displayed to team members. In some embodiments, an automatic prognosis may be generated.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: February 7, 2023
    Inventor: Nikody Keating
  • Patent number: 11534608
    Abstract: Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: December 27, 2022
    Assignee: IST, LLC
    Inventors: William J. Tyler, Wing Law, Douglas Jeffery, Rafal Piersiak
  • Patent number: 11491081
    Abstract: A wearable stimulator device can be used to treat nausea and vomiting resulting from pregnancy, gastroparesis, virtual reality use, motion sickness, chemotherapy, and post-surgical nausea and vomiting, or other conditions by stimulating the P6 point of a user's forearm. A method of treating nausea includes monitoring one or more physiological parameters of a user via a wearable device, for example a smartwatch. Based on the one or more physiological parameters, the P6 point of the user's forearm can be stimulated for a predetermined time, for example via vibrational stimulation effected via a smartwatch or other wearable device. Data regarding the user's physiological parameters, stimulation sessions, and user-provided input regarding treatment efficacy and user symptoms can be collected and analyzed at scale to develop improved treatment regimes, for example modifying stimulation waveforms and/or timing, and identifying physiological parameters useful for predicting the onset of nausea.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: November 8, 2022
    Assignee: Sense Relief Inc.
    Inventors: Andrei Akaikine, Sidhartha Ranjit Sinha, Moshe Zilversmit
  • Patent number: 11471676
    Abstract: Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 18, 2022
    Assignee: Novocure GmbH
    Inventors: Yoram Wasserman, Zeev Bomzon, Hadas Sara Hershkovich, Ariel Naveh, Moshe Giladi, Eilon Kirson, Golan Bar-Tal, Tali Voloshin-Sela
  • Patent number: 11464978
    Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 11, 2022
    Assignee: Galvani Bioelectronics Limited
    Inventors: Daniel John Chew, Matteo Donega, Isha Gupta
  • Patent number: 11446502
    Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: September 20, 2022
    Assignee: Galvani Bioelectronics Limited
    Inventors: Matteo Donega, Daniel John Chew, Isha Gupta
  • Patent number: 11426585
    Abstract: The present disclose relates to slurry electrodes that can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: August 30, 2022
    Inventors: Tina L. Vrabec, Jesse S. Wainright, Niloy Bhadra, Kevin L. Kilgore
  • Patent number: 11400279
    Abstract: The system and method of the present invention takes advantage of the laryngeal adductor reflex (LAR), previously thought to be repressed during general anesthesia, for CIONM without placement of an electrode on the vagus nerve.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: August 2, 2022
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Catherine F. Sinclair, Sedat Ulkatan, Maria Jose Tellez Garbayo
  • Patent number: 11369797
    Abstract: A neural stimulation and recording electrode assembly includes a selectively deformable guide tube. The guide tube includes a plurality of sequentially coupled connecting structures, wherein each connecting structure of the plurality of connecting structures has a respective central axis, and wherein at least one of the plurality of connecting structures is selectively deformable relative to the central axis of a sequential connecting structure of the plurality of connecting structures such that the central axis of the selectively deformable connecting structure is angularly oriented relative to the central axis of the sequential connecting structure.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: June 28, 2022
    Inventor: Arash Hadipour-Niktarash
  • Patent number: 11351368
    Abstract: Methods and apparatuses (systems, devices, etc.) for treating biological tissue to evoke one or more desirable biological and/or physiological effects using pulsed electric fields in the sub-microsecond range at very low electric field strength (e.g., less than 1 kV/cm) but at high (e.g., megahertz) frequencies.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: June 7, 2022
    Assignee: Old Dominion University Research Foundation
    Inventors: Andrei G. Pakhomov, Shu Xiao, Olga N. Pakhomova, Maura Casciola
  • Patent number: 11331480
    Abstract: In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the saphenous and/or tibial nerves. The stimulation could include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient, and modifying at least one brain or spinal cord autonomic feedback loop relating to bladder function based on the input to balance parasympathetic and sympathetic nervous system activity of the patient.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: May 17, 2022
    Assignee: Cala Health, Inc.
    Inventors: Samuel Richard Hamner, Serena HanYing Wong, Kathryn H. Rosenbluth, Peter Lin, Shahid Mallick, Erika Kristine Ross
  • Patent number: 11298502
    Abstract: Non-pharmaceuticals method of treating the effects of addiction withdrawal are described. The method includes providing a person with stimuli include visual and/or auditory stimuli which are pulsed at the rate of various types of brain waves. The use of the method lessens various withdrawal symptoms, such as anxiety, sleepiness, sweating, tearing of the eyes, running of the nose, goosebumps, shaking, hot flushes, cold flushes, bones aching, muscles aching, restlessness, nausea, vomiting, muscle twitching, stomach cramps, pain, the need to use an opioid, the desire to use an opioid, sleep disturbances. and the use of rescue medications.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: April 12, 2022
    Assignee: SANA HEALTH, INC.
    Inventor: Richard Hanbury
  • Patent number: 11253182
    Abstract: The present specification discloses an intraoperative neurophysiological monitoring (IONM) system including a computing device capable of executing an IONM software engine, a stimulation module having multiple ports and various stimulation components and recording electrodes. The system is used to implement transcranial electrical stimulation and motor evoked potential monitoring by positioning at least one recording electrode on a patient, connecting the stimulation components to at least one port on the stimulation module, positioning the stimulation components on a patient's head, activating, using the IONM software engine, at least one port, delivering stimulation to the patient; and recording a stimulatory response on the patient.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: February 22, 2022
    Inventors: Rose Rehfeldt, Ivan Amaya, John A. Cadwell, John A. Cadwell, Jr.
  • Patent number: 11197999
    Abstract: A patient treatment unit for delivering non-invasive pulsed energy to living tissue with a probe stimulus generator circuit configured to output, as a treatment signal, a sequence of DC electrical pulses at a controlled pulse frequency of about 20 kHz and having a pulse voltage defined by a variable supply voltage of the probe stimulus generator circuit. The unit includes primary and secondary probes for contacting a body, an intensity adjustment circuit configured to control the variable supply voltage, and an electronic timer display configured to display an elapsed time in decimal numbers in minute and second format. An electrical current of the pulses is in a range of 0.1-2 mA while the probes are contacting the body. An operating output voltage across the probes while conducting the treatment signal does not exceed a maximum operating output voltage of 165 VDC while the probes are contacting the body.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: December 14, 2021
    Assignee: TrueRelief, LLC
    Inventor: John Crosson
  • Patent number: 11134998
    Abstract: The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: October 5, 2021
    Assignee: Pacira CryoTech, Inc.
    Inventors: Ann Lee Cross, Erika Danielle Anderson-Bolden, Jessica Preciado Dummett, Eric Theodore Johansson, Paul Tanaka-Roche
  • Patent number: 11083892
    Abstract: The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for minimally invasive, targeted, vagus nerve stimulation (pVNS), and the efficacy of this approach with respect to microglial activation and the amelioration of cognitive dysfunction. The systems and methods of neuromodulation disclosed herein can be used to facilitate the treatment of various diseases associated with pathological neural activity.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: August 10, 2021
    Inventors: Niccolo Terrando, William Huffman, Warren Grill
  • Patent number: 11020590
    Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: June 1, 2021
    Inventors: Andrei G. Pakhomov, Olga N. Pakhomova, Shu Xiao
  • Patent number: 11020585
    Abstract: Damage from autoimmune diseases can be prevented or minimized by positioning a plurality of electrodes in or on a subject's body, and applying an AC voltage between the plurality of electrodes so as to impose an alternating electric field through the tissue that is being attacked by the autoimmune disease and/or draining lymph nodes associated with that tissue. The frequency and field strength of the alternating electric field are selected such that the alternating electric field inhibits proliferation of T cells in the tissue to an extent that reduces damage that is caused by the autoimmune disease.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: June 1, 2021
    Assignee: Novocure GmbH
    Inventors: Yaniv Alon, Tali Voloshin-Sela, Moshe Giladi
  • Patent number: 10980596
    Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a treatment tip that comprises both an energy delivery element and a cooling mechanism. As the treatment tip contacts the epithelial mucosa, the tip cools the mucosa by contact, and delivers energy through the epithelium to the underlying tissue, thereby creating a reverse thermal gradient. The effect of the applied heat is to remodel genital tissue by tightening it. Such remodeling may include a tighter vagina and a tighter introitus. The tightening may be a consequence of thermal denaturation of collagen as well as a longer term healing response in the tissue that includes an increased deposition of collagen.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: April 20, 2021
    Assignee: Viveve, Inc.
    Inventor: Jonathan B. Parmer
  • Patent number: 10974041
    Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 13, 2021
    Inventors: Daniel John Chew, Wouter Jacob De Jonge, Hans Jakob Kristoffer Famm, Sonal Patel, Olaf Welting
  • Patent number: 10960206
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 30, 2021
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Patent number: 10953225
    Abstract: A topical nerve activation patch includes a flexible substrate, a dermis conforming bottom surface of the substrate comprising adhesive and adapted to contact a dermis of a user, a flexible top outer surface of the substrate approximately parallel to the bottom surface, a plurality of electrodes positioned on the patch proximal to the bottom surface and located beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry that generates an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller and a boosted voltage circuit coupled to the switch and the power source.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: March 23, 2021
    Assignee: Neurostim OAB, Inc.
    Inventors: Michael B. Druke, Alan E. Loh, Robert W. Scott, Anthony Wei, Graham Harold Creasey, Hoo-Min D. Toong
  • Patent number: 10926086
    Abstract: Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: February 23, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Sangeeta S. Chavan, William M. Hanes, Kevin J. Tracey
  • Patent number: 10874846
    Abstract: The present disclosure provides a TENS electrode needle and a TENS device. The TENS electrode needle includes: a needle handle having a first electrode and a second electrode for providing pulse current signals with different polarities are arranged; and at least one first needle body and at least one second needle body. Each of the first needle body and the second needle body includes a first end and a second end. The first end of the first needle body is electrically connected to the first electrode, and the first end of the second needle body is electrically connected to the second electrode, so as to form an electrical field between the second end of the first needle body and the second end of the second needle body.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 29, 2020
    Inventor: Yangkun Jing
  • Patent number: 10849822
    Abstract: The disclosure discloses an antiemetic control device and a control method thereof, comprising a housing, a MCU single-chip microcontroller provided in the housing, a charging circuit, a discharging circuit and a rechargeable battery for supplying power, a button, a display screen, an alarm device and a plurality of mode indicator lights disposed on the housing, two electrodes and an optical pulse detecting unit disposed on the lower surface of the housing, and two wrist straps disposed on the housing. The disclosure has the characteristics of stable therapeutic effects.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: December 1, 2020
    Inventors: Jun Zhang, Yun Xiang, Lijuan Wang, Yurong Xu, Mingshan Sun
  • Patent number: 10842560
    Abstract: An ablation catheter configured to ablate tissue in a lung of a patient including: a flexible shaft that advances endobronchially into an airway of the lung and has an outer diameter of 2.0 mm or less; an ablation electrode attached to a distal portion of the flexible shaft and to deliver radiofrequency (RF) electrical current to the tissue and conductively connectable to an RF electrical energy source external to the patient; wherein an outer diameter of an assembly of the flexible shaft and the ablation electrode is no greater than 2.0 mm; a liquid outlet on the distal portion and configured to be in fluid communication with a source of hypertonic saline solution; and a first occluder attached to the flexible shaft proximal to the ablation electrode and proximal to the liquid outlet, wherein the first occluder is configured to expand to occlude the airway.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: November 24, 2020
    Assignee: Zidan Medical Inc.
    Inventors: Dorin Panescu, Shashank Raina, Mark Gelfand, Mark Leung, Simplicio Velilla
  • Patent number: 10842559
    Abstract: System and method for locating and identifying nerves innervating the wall of arteries such as the renal artery are disclosed. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The method includes at least the steps to evaluate a change in physiological parameters after energy is delivered to an arterial wall; and to determine the type of nerve that the energy was directed to (none, sympathetic or parasympathetic) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using this method. Also provided are catheters for performing the mapping and ablating functions.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: November 24, 2020
    Inventor: Jie Wang
  • Patent number: 10799221
    Abstract: A device for providing a magnetic force to a sampling needle. The device may include with a sheath having a proximal end and a distal end, a needle slidably received within the distal end of the sheath and an actuator component located at least partially within the distal end of the sheath, the actuator component configured to apply a magnetic force to the needle. The actuator component may include a coil located within the distal end of the sheath and a current source in electrical communication with the coil. The current source may include one or more capacitors, a DC power source, a first switch configured to cause the DC power source to charge the capacitors upon activation and a second switch configured to cause the capacitors to discharge to the coil upon activation.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 13, 2020
    Assignee: Gyrus ACMI, Inc.
    Inventor: Brandon J. Shuman
  • Patent number: 10780285
    Abstract: An implantable pulse generator (IPG) is disclosed having an improved ability to steer anodic and cathodic currents between the IPG's electrodes. Each electrode node has at least one PDAC/NDAC pair to source/sink or sink/source a stimulation current to an associated electrode node. Each PDAC and NDAC receives a current with a magnitude indicative of a total anodic and cathodic current, and data indicative of a percentage of that total that each PDAC and NDAC will produce in the patient's tissue at any given time, which activates a number of branches in each PDAC or NDAC. Each PDAC and NDAC may also receive one or more resolution control signals specifying an increment by which the stimulation current may be adjusted at each electrode. The current received by each PDAC and NDAC is generated by a master DAC, and is preferably distributed to the PDACs and NDACs by distribution circuitry.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 22, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Pujitha Weerakoon, David M. Wagenbach, Philip L. Weiss, Goran N. Marnfeldt, Kiran K. Gururaj
  • Patent number: 10741446
    Abstract: A method of wafer dicing includes singulating dies from a semiconductor wafer. The method further includes depositing a metal layer on back sides of the singulated dies, wherein a portion of the metal layer continues beyond the backs sides of the singulated dies to deposit at least partially on lateral sides of the singulated dies. A packaged die includes a semiconductor die and a metal outer layer deposited on the back side of the semiconductor die and on a portion of the lateral side of the semiconductor die nearest the back side. The packaged die further includes a substrate mounted to the back side of the semiconductor die a die attach material that bonds the substrate to the metal outer layer deposited on the semiconductor die, wherein the metal outer layer and the die attach material surround the back edge of the semiconductor die.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: August 11, 2020
    Assignee: NXP USA, Inc.
    Inventors: Jaynal A Molla, Lakshminarayan Viswanathan, David Abdo, Colby Greg Rampley, Fernando A. Santos
  • Patent number: 10682509
    Abstract: The present invention relates to a device for providing neuromuscular stimulation. The device comprises a positive electrode, a plurality of negative electrodes, a non-conductive substrate and a control unit for activating the electrodes. The control unit of the device activates the negative electrodes in a predetermined sequence, so as to deliver electrical stimulus to a user, wherein the predetermined sequence is repeated with an increasing level of stimulus until a predetermined outcome is achieved. Additionally each negative electrode of the devices comprises at least one conductive track mounted on the non-conductive substrate wherein at least one pair of negative electrodes overlap such that the conductive track or tracks of a first negative electrode of the pair overlap with the electrode footprint, but not the conductive tracks, of a second negative electrode of the pair.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 16, 2020
    Assignee: Sky Medical Technology Ltd
    Inventors: Jonathan Fenton, Duncan Bain, Martin Gordon, Benjamin Gordon
  • Patent number: 10646164
    Abstract: A wirelessly powered implantable stimulator device includes one or more antenna configured to receive an input signal non-inductively from an external antenna, the input signal containing (i) electrical energy to operate the implantable stimulator device and (ii) configuration data according to which a pulse-density modulation (PDM) encoded stimulus waveform signal is retrieved to synthesize a desired stimulation waveform; a circuit coupled to the one or more antenna; and one or more electrodes coupled to the circuit and configured to apply the desired stimulation waveform to neural tissue, wherein the circuit is configured to: rectify the input signal received at the one or more antennas non-inductively; extract the electrical energy and the configuration data from the input signal; and in accordance with the extracted configuration data, retrieve the pulse-density modulation (PDM) signal to synthesize the desired stimulation waveform therefrom.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 12, 2020
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Bertan Bakkaloglu, Chad David Andresen
  • Patent number: 10617880
    Abstract: A system and method for powering a medical device that includes a fixture configured for periodic patient proximity; external electrical coupling device integrated into the fixture wherein the external electrical coupling device comprises at least one external energy coupler and is configured to detect presence of an electrical medical device implant in a transmission zone of the external electrical coupling device; an electrical medical device implant, wherein the electrical medical device implant comprises at least one implant energy coupler; and wherein the external electrical coupling device is configured to couple to the implantable medical device through a wireless energy transmission between the external energy coupler and the implant energy coupler when presence of the implantable medical device is within a transmission zone.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 14, 2020
    Assignee: Intelligent Implants Limited
    Inventors: Erik Zellmer, John Zellmer, Rory Murphy
  • Patent number: 10593231
    Abstract: A system for monitoring stomach fullness includes an ultrasound transponder configured to transmit ultrasound signals and receive reflected ultrasound signals. A processor is configured to process the received reflected ultrasound signals to determine level of stomach fullness and output fullness data indicative of the determined level of stomach fullness. A memory stores calibration data representative of calibrated levels of stomach fullness including empty and full. A stored program has executable codes to, upon execution, control the ultrasound transponder, compare the fullness data against the calibration data, and output alert data upon a match of a preset fullness level.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: March 17, 2020
    Inventors: Amos Cahan, Theodore Gerard Van Kessel
  • Patent number: 10518088
    Abstract: The invention comprises SCENAR-therapy or other methods of electric stimulation, where an inductive energy storage unit is used to generate stimuli, and can be applied for therapeutic, rehabilitation, research, and preventive purposes. The invention includes applying electrodes on tissues and transmitting through them bursts of electrical stimuli. The stimuli are controlled based on processes occurring in these tissues as a result of their interaction with the electrical stimuli. The exposure duration and/or stimuli parameters are controlled according to the free oscillation parameters. The invention includes three types of parameter measurements: measuring parameters while the current stimulus burst is acting; measuring parameters of the last stimulus of each burst; and generating a probing sole stimulus before the main burst and measuring parameters of this stimulus.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 31, 2019
    Assignee: RITM OKB ZAO
    Inventors: Yakov Zalmanovich Grinberg, Yury Yurievich Starovoytov, Mikhail Anatolievich Unakafov
  • Patent number: 10485971
    Abstract: A system and method for the transcutaneous stimulation of various nerves such as the phrenic, hypoglossal, and vagal nerves is provided. The stimulation elicits a corresponding muscle response without reported pain.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 26, 2019
    Assignee: Avent, Inc.
    Inventors: Eric A. Schepis, Carolyn Y. Sargent
  • Patent number: 10485605
    Abstract: An apparatus and method stimulate or sense neurons or groups of neurons in a subject, e.g., a human or animal brain, with positional dependence. This utility is provided in part by utilizing individually-addressable Radio-Frequency IDentification (RFID) coils so that locations of those coils in the brain would be monitored and known.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 26, 2019
    Assignee: Weinberg Medical Physics, Inc.
    Inventor: Irving N. Weinberg
  • Patent number: 10449355
    Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include one or more electrode leads coupled to an implantable pulse generator (IPG) and a tunneler system for subcutaneously implanting a proximal portion of the lead(s). The system may also include a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 22, 2019
    Assignee: Mainstay Medical Limited
    Inventors: John Beck, Jason Skubitz, Peter Crosby, Henry DeMorett, Jason Alan Shiroff
  • Patent number: 10426945
    Abstract: Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 1, 2019
    Assignee: Thync Global, Inc.
    Inventors: William J. Tyler, Wing Law, Douglas Jeffery, Rafal Piersiak
  • Patent number: 10420939
    Abstract: Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. Methods include placing an electrical lead in electrical communication with the injured or damaged nerve. Methods further include temporarily stimulating the nerve and/or applying sub-threshold stimulation to the nerve to promote neuroregeneration of the nerve. The nerve can be a peripheral nerve.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: September 24, 2019
    Inventors: Bradley C. Gill, Yaw A. Nyame, Eric A. Klein
  • Patent number: 10232178
    Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: March 19, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10207109
    Abstract: A neuromodulation system comprises electrical terminals configured for being respectively coupled to electrodes. The system further comprises modulation output circuitry configured for respectively outputting individual electrical pulse trains in timing channels to the electrical terminals, wherein each of the pulse trains has a modulation pulse, and at least one of the pulse trains has a charge recovery pulse associated with the modulation pulse of the respective pulse train. The neuromodulation system further comprises control circuitry configured for controlling the modulation output circuitry in a manner that sequentially outputs the modulation pulses of the respective pulse trains to a common set of the electrical terminals without an intervening charge recovery pulse, and outputting the charge recovery pulse(s) to the common set of the electrical terminals subsequent to the sequential modulation pulses, thereby creating a combined electrical pulse train at the common set of electrical terminals.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: February 19, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Changfang Zhu, Que T. Doan
  • Patent number: 10201706
    Abstract: Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's inflammatory disorder.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: February 12, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Jan Schwab, Phillip Popovich, Ali R. Rezai
  • Patent number: 10183163
    Abstract: Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system for controlling a therapy provided to a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The operational instruction defines at least one of a pulse duration, a pulse frequency, a pulse number, and a pulse amplitude. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: January 22, 2019
    Assignee: The General Hospital Corporation
    Inventors: Alexander Golberg, Martin L. Yarmush, Robert L. Sheridan, William Gerald Austen, G. Felix Broelsch, Boris Rubinsky, Michael Belkin
  • Patent number: 10172663
    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: January 8, 2019
    Assignee: Ablative Solutions, Inc.
    Inventors: David R. Fischell, Tim A. Fischell
  • Patent number: 10159420
    Abstract: A nerve impulse signal stimulation device and a method for fabricating the same are provided. The nerve impulse signal stimulation device includes: a substrate having a first surface and a second surface opposite to the first surface; a first metal layer formed on the first surface of the substrate; a second metal layer formed on the first metal layer; a plurality of openings exposing a portion of the first surface of the substrate, a portion of the first metal layer and a portion of the second metal layer; and a ferromagnetic material attached to the second surface of the substrate. The openings cause the nerve impulse signal stimulation device to obtain a parallel circuit structure, thereby increasing the current load and the magnetic field intensity, reducing the size of the device, and ensuring the safety of operations.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: December 25, 2018
    Assignee: National Chiao Tung University
    Inventors: Yu-Ting Cheng, Chung-Yu Wu, Jui-Sheng Sun, Yu-Min Fu, Che-Yu Chen, Xin-Hong Qian
  • Patent number: 10112050
    Abstract: A neuromodulation system and method of providing sub-threshold therapy to a patient. An anodic perception threshold of super-threshold electrical energy and a cathodic perception threshold of super-threshold electrical energy are determined for a plurality of electrode sets. A ratio between the anodic perception threshold and the cathodic perception threshold is calculated for each of the electrode sets. An effective electrode set is selected based on the ratio between the anodic perception threshold and the cathodic perception threshold.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 30, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Dongchul Lee, Changfang Zhu
  • Patent number: 10092758
    Abstract: A method is provided to deliver C tactile fiber stimulation to nervous tissue of a patient. The method comprises delivering a first tactile stimulation waveform to a first electrode combination within an array of electrodes located proximate to nervous tissue of interest. The method further provides sequentially delivering successive tactile stimulation waveforms to successive electrode combinations within the array of electrodes. The first and successive tactile stimulation waveforms include at least one series of pulses having a pulse amplitude and pulse frequency. Delaying delivery of the successive tactile stimulation waveforms by a firing delay, the pulse amplitude, pulse frequency and firing delay represent therapy parameters. The method manages at least one of the therapy parameters of the first and successive tactile stimulation waveforms to excite C tactile fibers of the nervous tissue of interest.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 9, 2018
    Inventor: Dirk De Ridder