Pulse Signal Patents (Class 607/72)
  • Patent number: 11134998
    Abstract: The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: October 5, 2021
    Assignee: Pacira CryoTech, Inc.
    Inventors: Ann Lee Cross, Erika Danielle Anderson-Bolden, Jessica Preciado Dummett, Eric Theodore Johansson, Paul Tanaka-Roche
  • Patent number: 11083892
    Abstract: The present disclosure provides systems and methods relating to neuromodulation. In particular, the present disclosure provides systems and methods for minimally invasive, targeted, vagus nerve stimulation (pVNS), and the efficacy of this approach with respect to microglial activation and the amelioration of cognitive dysfunction. The systems and methods of neuromodulation disclosed herein can be used to facilitate the treatment of various diseases associated with pathological neural activity.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: August 10, 2021
    Assignee: DUKE UNIVERSITY
    Inventors: Niccolo Terrando, William Huffman, Warren Grill
  • Patent number: 11020590
    Abstract: Provided herein are methods of generating a biologically effective unipolar nanosecond electric pulse by superposing two biologically ineffective bipolar nanosecond electric pulses and related aspects, such as electroporation and/or therapeutic applications of these methods to non-invasively target electrostimulation (ES) selectively to deep tissues and organs.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: June 1, 2021
    Assignee: OLD DOMINION UNIVERSITY RESEARCH FOUNDATION
    Inventors: Andrei G. Pakhomov, Olga N. Pakhomova, Shu Xiao
  • Patent number: 11020585
    Abstract: Damage from autoimmune diseases can be prevented or minimized by positioning a plurality of electrodes in or on a subject's body, and applying an AC voltage between the plurality of electrodes so as to impose an alternating electric field through the tissue that is being attacked by the autoimmune disease and/or draining lymph nodes associated with that tissue. The frequency and field strength of the alternating electric field are selected such that the alternating electric field inhibits proliferation of T cells in the tissue to an extent that reduces damage that is caused by the autoimmune disease.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: June 1, 2021
    Assignee: Novocure GmbH
    Inventors: Yaniv Alon, Tali Voloshin-Sela, Moshe Giladi
  • Patent number: 10980596
    Abstract: This invention relates generally to apparatus and methods for tightening tissue of the female genitalia by heating targeted connective tissue with radiant energy, while cooling the mucosal epithelial surface over the target tissue to protect it from the heat. Embodiments include a treatment tip that comprises both an energy delivery element and a cooling mechanism. As the treatment tip contacts the epithelial mucosa, the tip cools the mucosa by contact, and delivers energy through the epithelium to the underlying tissue, thereby creating a reverse thermal gradient. The effect of the applied heat is to remodel genital tissue by tightening it. Such remodeling may include a tighter vagina and a tighter introitus. The tightening may be a consequence of thermal denaturation of collagen as well as a longer term healing response in the tissue that includes an increased deposition of collagen.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: April 20, 2021
    Assignee: Viveve, Inc.
    Inventor: Jonathan B. Parmer
  • Patent number: 10974041
    Abstract: The invention provides devices, apparatuses, systems and methods for treating and ameliorating inflammation of the gut. In particular, the invention provides devices, apparatuses and methods in which a neuromodulatory signal is delivered a splenic nerve and/or superior mesenteric plexus (SMP). The signal is able to treat inflammatory disorders, e.g., colitis, for example in Inflammatory Bowel Disease.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 13, 2021
    Assignees: GALVANI BIOELECTRONICS LIMITED, ACADEMISCH MEDISCH CENTRUM
    Inventors: Daniel John Chew, Wouter Jacob De Jonge, Hans Jakob Kristoffer Famm, Sonal Patel, Olaf Welting
  • Patent number: 10960206
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: March 30, 2021
    Assignee: LEONHARDT VENTURES LLC
    Inventors: Howard J. Leonhardt, Jorge Genovese
  • Patent number: 10953225
    Abstract: A topical nerve activation patch includes a flexible substrate, a dermis conforming bottom surface of the substrate comprising adhesive and adapted to contact a dermis of a user, a flexible top outer surface of the substrate approximately parallel to the bottom surface, a plurality of electrodes positioned on the patch proximal to the bottom surface and located beneath the top outer surface and coupled to the flexible substrate, a power source, and electronic circuitry that generates an output voltage applied to the electrodes. The electronic circuitry includes a controller, a voltage monitoring circuit coupled to the controller, a current monitoring circuit coupled to the controller, a switch coupled to the controller and a boosted voltage circuit coupled to the switch and the power source.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: March 23, 2021
    Assignee: Neurostim OAB, Inc.
    Inventors: Michael B. Druke, Alan E. Loh, Robert W. Scott, Anthony Wei, Graham Harold Creasey, Hoo-Min D. Toong
  • Patent number: 10926086
    Abstract: Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: February 23, 2021
    Assignee: The Feinstein Institutes for Medical Research
    Inventors: Sangeeta S. Chavan, William M. Hanes, Kevin J. Tracey
  • Patent number: 10874846
    Abstract: The present disclosure provides a TENS electrode needle and a TENS device. The TENS electrode needle includes: a needle handle having a first electrode and a second electrode for providing pulse current signals with different polarities are arranged; and at least one first needle body and at least one second needle body. Each of the first needle body and the second needle body includes a first end and a second end. The first end of the first needle body is electrically connected to the first electrode, and the first end of the second needle body is electrically connected to the second electrode, so as to form an electrical field between the second end of the first needle body and the second end of the second needle body.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 29, 2020
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., HEFEI BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.
    Inventor: Yangkun Jing
  • Patent number: 10849822
    Abstract: The disclosure discloses an antiemetic control device and a control method thereof, comprising a housing, a MCU single-chip microcontroller provided in the housing, a charging circuit, a discharging circuit and a rechargeable battery for supplying power, a button, a display screen, an alarm device and a plurality of mode indicator lights disposed on the housing, two electrodes and an optical pulse detecting unit disposed on the lower surface of the housing, and two wrist straps disposed on the housing. The disclosure has the characteristics of stable therapeutic effects.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: December 1, 2020
    Inventors: Jun Zhang, Yun Xiang, Lijuan Wang, Yurong Xu, Mingshan Sun
  • Patent number: 10842560
    Abstract: An ablation catheter configured to ablate tissue in a lung of a patient including: a flexible shaft that advances endobronchially into an airway of the lung and has an outer diameter of 2.0 mm or less; an ablation electrode attached to a distal portion of the flexible shaft and to deliver radiofrequency (RF) electrical current to the tissue and conductively connectable to an RF electrical energy source external to the patient; wherein an outer diameter of an assembly of the flexible shaft and the ablation electrode is no greater than 2.0 mm; a liquid outlet on the distal portion and configured to be in fluid communication with a source of hypertonic saline solution; and a first occluder attached to the flexible shaft proximal to the ablation electrode and proximal to the liquid outlet, wherein the first occluder is configured to expand to occlude the airway.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: November 24, 2020
    Assignee: Zidan Medical Inc.
    Inventors: Dorin Panescu, Shashank Raina, Mark Gelfand, Mark Leung, Simplicio Velilla
  • Patent number: 10842559
    Abstract: System and method for locating and identifying nerves innervating the wall of arteries such as the renal artery are disclosed. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The method includes at least the steps to evaluate a change in physiological parameters after energy is delivered to an arterial wall; and to determine the type of nerve that the energy was directed to (none, sympathetic or parasympathetic) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using this method. Also provided are catheters for performing the mapping and ablating functions.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: November 24, 2020
    Assignee: SYMAP MEDICAL (SUZHOU), LIMITED
    Inventor: Jie Wang
  • Patent number: 10799221
    Abstract: A device for providing a magnetic force to a sampling needle. The device may include with a sheath having a proximal end and a distal end, a needle slidably received within the distal end of the sheath and an actuator component located at least partially within the distal end of the sheath, the actuator component configured to apply a magnetic force to the needle. The actuator component may include a coil located within the distal end of the sheath and a current source in electrical communication with the coil. The current source may include one or more capacitors, a DC power source, a first switch configured to cause the DC power source to charge the capacitors upon activation and a second switch configured to cause the capacitors to discharge to the coil upon activation.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: October 13, 2020
    Assignee: Gyrus ACMI, Inc.
    Inventor: Brandon J. Shuman
  • Patent number: 10780285
    Abstract: An implantable pulse generator (IPG) is disclosed having an improved ability to steer anodic and cathodic currents between the IPG's electrodes. Each electrode node has at least one PDAC/NDAC pair to source/sink or sink/source a stimulation current to an associated electrode node. Each PDAC and NDAC receives a current with a magnitude indicative of a total anodic and cathodic current, and data indicative of a percentage of that total that each PDAC and NDAC will produce in the patient's tissue at any given time, which activates a number of branches in each PDAC or NDAC. Each PDAC and NDAC may also receive one or more resolution control signals specifying an increment by which the stimulation current may be adjusted at each electrode. The current received by each PDAC and NDAC is generated by a master DAC, and is preferably distributed to the PDACs and NDACs by distribution circuitry.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: September 22, 2020
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Pujitha Weerakoon, David M. Wagenbach, Philip L. Weiss, Goran N. Marnfeldt, Kiran K. Gururaj
  • Patent number: 10741446
    Abstract: A method of wafer dicing includes singulating dies from a semiconductor wafer. The method further includes depositing a metal layer on back sides of the singulated dies, wherein a portion of the metal layer continues beyond the backs sides of the singulated dies to deposit at least partially on lateral sides of the singulated dies. A packaged die includes a semiconductor die and a metal outer layer deposited on the back side of the semiconductor die and on a portion of the lateral side of the semiconductor die nearest the back side. The packaged die further includes a substrate mounted to the back side of the semiconductor die a die attach material that bonds the substrate to the metal outer layer deposited on the semiconductor die, wherein the metal outer layer and the die attach material surround the back edge of the semiconductor die.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: August 11, 2020
    Assignee: NXP USA, Inc.
    Inventors: Jaynal A Molla, Lakshminarayan Viswanathan, David Abdo, Colby Greg Rampley, Fernando A. Santos
  • Patent number: 10682509
    Abstract: The present invention relates to a device for providing neuromuscular stimulation. The device comprises a positive electrode, a plurality of negative electrodes, a non-conductive substrate and a control unit for activating the electrodes. The control unit of the device activates the negative electrodes in a predetermined sequence, so as to deliver electrical stimulus to a user, wherein the predetermined sequence is repeated with an increasing level of stimulus until a predetermined outcome is achieved. Additionally each negative electrode of the devices comprises at least one conductive track mounted on the non-conductive substrate wherein at least one pair of negative electrodes overlap such that the conductive track or tracks of a first negative electrode of the pair overlap with the electrode footprint, but not the conductive tracks, of a second negative electrode of the pair.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 16, 2020
    Assignee: Sky Medical Technology Ltd
    Inventors: Jonathan Fenton, Duncan Bain, Martin Gordon, Benjamin Gordon
  • Patent number: 10646164
    Abstract: A wirelessly powered implantable stimulator device includes one or more antenna configured to receive an input signal non-inductively from an external antenna, the input signal containing (i) electrical energy to operate the implantable stimulator device and (ii) configuration data according to which a pulse-density modulation (PDM) encoded stimulus waveform signal is retrieved to synthesize a desired stimulation waveform; a circuit coupled to the one or more antenna; and one or more electrodes coupled to the circuit and configured to apply the desired stimulation waveform to neural tissue, wherein the circuit is configured to: rectify the input signal received at the one or more antennas non-inductively; extract the electrical energy and the configuration data from the input signal; and in accordance with the extracted configuration data, retrieve the pulse-density modulation (PDM) signal to synthesize the desired stimulation waveform therefrom.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 12, 2020
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Bertan Bakkaloglu, Chad David Andresen
  • Patent number: 10617880
    Abstract: A system and method for powering a medical device that includes a fixture configured for periodic patient proximity; external electrical coupling device integrated into the fixture wherein the external electrical coupling device comprises at least one external energy coupler and is configured to detect presence of an electrical medical device implant in a transmission zone of the external electrical coupling device; an electrical medical device implant, wherein the electrical medical device implant comprises at least one implant energy coupler; and wherein the external electrical coupling device is configured to couple to the implantable medical device through a wireless energy transmission between the external energy coupler and the implant energy coupler when presence of the implantable medical device is within a transmission zone.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 14, 2020
    Assignee: Intelligent Implants Limited
    Inventors: Erik Zellmer, John Zellmer, Rory Murphy
  • Patent number: 10593231
    Abstract: A system for monitoring stomach fullness includes an ultrasound transponder configured to transmit ultrasound signals and receive reflected ultrasound signals. A processor is configured to process the received reflected ultrasound signals to determine level of stomach fullness and output fullness data indicative of the determined level of stomach fullness. A memory stores calibration data representative of calibrated levels of stomach fullness including empty and full. A stored program has executable codes to, upon execution, control the ultrasound transponder, compare the fullness data against the calibration data, and output alert data upon a match of a preset fullness level.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: March 17, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Amos Cahan, Theodore Gerard Van Kessel
  • Patent number: 10518088
    Abstract: The invention comprises SCENAR-therapy or other methods of electric stimulation, where an inductive energy storage unit is used to generate stimuli, and can be applied for therapeutic, rehabilitation, research, and preventive purposes. The invention includes applying electrodes on tissues and transmitting through them bursts of electrical stimuli. The stimuli are controlled based on processes occurring in these tissues as a result of their interaction with the electrical stimuli. The exposure duration and/or stimuli parameters are controlled according to the free oscillation parameters. The invention includes three types of parameter measurements: measuring parameters while the current stimulus burst is acting; measuring parameters of the last stimulus of each burst; and generating a probing sole stimulus before the main burst and measuring parameters of this stimulus.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 31, 2019
    Assignee: RITM OKB ZAO
    Inventors: Yakov Zalmanovich Grinberg, Yury Yurievich Starovoytov, Mikhail Anatolievich Unakafov
  • Patent number: 10485971
    Abstract: A system and method for the transcutaneous stimulation of various nerves such as the phrenic, hypoglossal, and vagal nerves is provided. The stimulation elicits a corresponding muscle response without reported pain.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 26, 2019
    Assignee: Avent, Inc.
    Inventors: Eric A. Schepis, Carolyn Y. Sargent
  • Patent number: 10485605
    Abstract: An apparatus and method stimulate or sense neurons or groups of neurons in a subject, e.g., a human or animal brain, with positional dependence. This utility is provided in part by utilizing individually-addressable Radio-Frequency IDentification (RFID) coils so that locations of those coils in the brain would be monitored and known.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 26, 2019
    Assignee: Weinberg Medical Physics, Inc.
    Inventor: Irving N. Weinberg
  • Patent number: 10449355
    Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include one or more electrode leads coupled to an implantable pulse generator (IPG) and a tunneler system for subcutaneously implanting a proximal portion of the lead(s). The system may also include a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 22, 2019
    Assignee: Mainstay Medical Limited
    Inventors: John Beck, Jason Skubitz, Peter Crosby, Henry DeMorett, Jason Alan Shiroff
  • Patent number: 10426945
    Abstract: Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 1, 2019
    Assignee: Thync Global, Inc.
    Inventors: William J. Tyler, Wing Law, Douglas Jeffery, Rafal Piersiak
  • Patent number: 10420939
    Abstract: Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. Methods include placing an electrical lead in electrical communication with the injured or damaged nerve. Methods further include temporarily stimulating the nerve and/or applying sub-threshold stimulation to the nerve to promote neuroregeneration of the nerve. The nerve can be a peripheral nerve.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: September 24, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Bradley C. Gill, Yaw A. Nyame, Eric A. Klein
  • Patent number: 10232178
    Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: March 19, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10207109
    Abstract: A neuromodulation system comprises electrical terminals configured for being respectively coupled to electrodes. The system further comprises modulation output circuitry configured for respectively outputting individual electrical pulse trains in timing channels to the electrical terminals, wherein each of the pulse trains has a modulation pulse, and at least one of the pulse trains has a charge recovery pulse associated with the modulation pulse of the respective pulse train. The neuromodulation system further comprises control circuitry configured for controlling the modulation output circuitry in a manner that sequentially outputs the modulation pulses of the respective pulse trains to a common set of the electrical terminals without an intervening charge recovery pulse, and outputting the charge recovery pulse(s) to the common set of the electrical terminals subsequent to the sequential modulation pulses, thereby creating a combined electrical pulse train at the common set of electrical terminals.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: February 19, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Changfang Zhu, Que T. Doan
  • Patent number: 10201706
    Abstract: Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's inflammatory disorder.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: February 12, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Jan Schwab, Phillip Popovich, Ali R. Rezai
  • Patent number: 10183163
    Abstract: Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system for controlling a therapy provided to a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The operational instruction defines at least one of a pulse duration, a pulse frequency, a pulse number, and a pulse amplitude. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: January 22, 2019
    Assignee: The General Hospital Corporation
    Inventors: Alexander Golberg, Martin L. Yarmush, Robert L. Sheridan, William Gerald Austen, G. Felix Broelsch, Boris Rubinsky, Michael Belkin
  • Patent number: 10172663
    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: January 8, 2019
    Assignee: Ablative Solutions, Inc.
    Inventors: David R. Fischell, Tim A. Fischell
  • Patent number: 10159420
    Abstract: A nerve impulse signal stimulation device and a method for fabricating the same are provided. The nerve impulse signal stimulation device includes: a substrate having a first surface and a second surface opposite to the first surface; a first metal layer formed on the first surface of the substrate; a second metal layer formed on the first metal layer; a plurality of openings exposing a portion of the first surface of the substrate, a portion of the first metal layer and a portion of the second metal layer; and a ferromagnetic material attached to the second surface of the substrate. The openings cause the nerve impulse signal stimulation device to obtain a parallel circuit structure, thereby increasing the current load and the magnetic field intensity, reducing the size of the device, and ensuring the safety of operations.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: December 25, 2018
    Assignee: National Chiao Tung University
    Inventors: Yu-Ting Cheng, Chung-Yu Wu, Jui-Sheng Sun, Yu-Min Fu, Che-Yu Chen, Xin-Hong Qian
  • Patent number: 10112050
    Abstract: A neuromodulation system and method of providing sub-threshold therapy to a patient. An anodic perception threshold of super-threshold electrical energy and a cathodic perception threshold of super-threshold electrical energy are determined for a plurality of electrode sets. A ratio between the anodic perception threshold and the cathodic perception threshold is calculated for each of the electrode sets. An effective electrode set is selected based on the ratio between the anodic perception threshold and the cathodic perception threshold.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 30, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Dongchul Lee, Changfang Zhu
  • Patent number: 10092758
    Abstract: A method is provided to deliver C tactile fiber stimulation to nervous tissue of a patient. The method comprises delivering a first tactile stimulation waveform to a first electrode combination within an array of electrodes located proximate to nervous tissue of interest. The method further provides sequentially delivering successive tactile stimulation waveforms to successive electrode combinations within the array of electrodes. The first and successive tactile stimulation waveforms include at least one series of pulses having a pulse amplitude and pulse frequency. Delaying delivery of the successive tactile stimulation waveforms by a firing delay, the pulse amplitude, pulse frequency and firing delay represent therapy parameters. The method manages at least one of the therapy parameters of the first and successive tactile stimulation waveforms to excite C tactile fibers of the nervous tissue of interest.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 9, 2018
    Inventor: Dirk De Ridder
  • Patent number: 10086198
    Abstract: A bioelectric signal generation and application method generates a signal that comprises a succession of pulses arranged either in continuous trains or in separated bursts; in which each pulse within a train or burst comprises at least three distinct intervals of time; in which the first said interval of time has one definite polarity and sufficient current density and duration to cause motion of calcium ions (Ca++) in relation to less strongly charged components of a body, cell or tissue, such as proteins and especially the protein calmodulin (CaM); in which the second said interval of time has substantially zero current density and is of sufficient duration to allow any proteins or other molecules which became distorted by electric fields present during said first interval, and especially CaM, to relax back into their normal, undistorted shapes, said first and second intervals of time thus comprising a “two-step electric process.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: October 2, 2018
    Assignee: APOGEE MEDICAL, LLC
    Inventor: James W Kronberg
  • Patent number: 9981134
    Abstract: A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to electrodes, modulation output circuitry configured for respectively outputting a plurality of individual electrical pulse trains in a plurality of timing channels to the electrical terminals, wherein each of the timing channels prevents the respective pulse train from having a specific characteristic, and control circuitry configured for controlling the modulation output circuitry in a manner that outputs the pulse trains to a common set of the electrical terminals, thereby creating a combined electrical pulse train at the common set of electrical terminals that has the specific characteristic. A method of providing therapy to a patient comprises delivering a plurality of electrical pulse trains respectively in a plurality of timing channels to a common set of electrodes implanted within the patient, thereby creating a combined electrical pulse train at the common set of electrical terminals.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 29, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Que T. Doan, Changfang Zhu
  • Patent number: 9950174
    Abstract: An implantable pulse generator (IPG) that generates spinal cord stimulation signals for a human body includes a timing generator and high frequency generator. The timing generator generates timing signals that represent stimulation signals for multiple channels. The high frequency generator determines whether to modulate the timing signals and modulates them at a burst frequency according to stored burst parameters if the decision is yes. As such, the IPG provides the ability to generate both the low frequency and high frequency stimulation signals in different channels according to user programming.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 24, 2018
    Assignee: GLOBUS MEDICAL, INC.
    Inventors: Christopher Biele, Raghavendra Angara, Saif Khalil
  • Patent number: 9937353
    Abstract: According to an embodiment of a method performed by an implantable medical device to deliver a neural stimulation therapy to a patient, a lower dose of the neural stimulation therapy is delivered to the patient. The dose of the neural stimulation therapy is automatically increased from the lower dose to a higher dose, and the higher dose of the neural stimulation therapy is delivered to the patient. A trigger that is controlled by the patient is detected, and the dose of the neural stimulation therapy is automatically returned from the higher dose back to the lower dose in response to detecting the trigger.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: April 10, 2018
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Stephen J. Hahn, Jason J. Hamann, David J. Ternes
  • Patent number: 9867937
    Abstract: A portable infusion pump can communicate with glucose monitor, such as a continuous glucose monitor (CGM), to receive continuous feedback relating to a user's blood glucose level during insulin or other medicament therapy and can automatically deliver insulin to a user when the CGM data indicates a need for additional insulin. Due to potential unreliability in the correlation of the CGM data to the user's actual blood glucose level, risk mitigation can be employed to limit the amount of extra insulin that can be delivered by the pump in response to the CGM data.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: January 16, 2018
    Assignee: Tandem Diabetes Care, Inc.
    Inventors: Sean Saint, Michael Rosinko
  • Patent number: 9844676
    Abstract: Techniques for facilitating communication between an implantable device and an external device are provided. In one example, an implantable device includes a data packet component and a communication component. The data packet component can insert information associated with the implantable device in a defined service field of an advertising data packet. The defined service field can be selected from one or more service fields of the advertising data packet based on the information associated with the implantable device. The communication component can transmit the advertising data packet. The external device can include a scanning component that can scan one or more service fields of the advertising data packet via an advertising communication channel, and a communication component that can establish a communication link with the implantable device in response to a determination that a criterion associated with a service field is satisfied.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: December 19, 2017
    Assignee: Medtronic, Inc.
    Inventors: Bo Zhang, Matthew R. Yoder
  • Patent number: 9775995
    Abstract: The invention provides the use of electrical pulses (I, W) to reduce, improve, heal or prevent recurrence of a chronic ulcer, comprising administering to a need (1, 2, 3) an effective amount of an electric stimulation in multiple treatment sessions, wherein the electric stimulation stimulates the lymphatic system.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: October 3, 2017
    Assignee: BODYFLOW INTERNATIONAL PTY LTD ACN
    Inventor: Joe Di Santo
  • Patent number: 9770598
    Abstract: A connector for an implantable electrical medical device includes a connector lumen defined in an elongated connector housing and adapted for receiving a portion of a lead. Connector-contact assemblies are disposed in the connector lumen and adapted to couple to terminals of the lead when the lead is received by the connector lumen. Each of the connector-contact assemblies includes a contact body. An inner surface of the contact body defines an open center portion. A first base is disposed along a first end of the contact body, and a second base is disposed along an opposing second end of the contact body and is coupled to the first base. Biasing members are attached to the first base and extend towards the second base. The biasing members are not attached to the second base. When the lead is received by the connector lumen the biasing members physically contact the received lead.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: September 26, 2017
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Zdzislaw Bernard Malinowski, Jeffery Van Funderburk
  • Patent number: 9522281
    Abstract: An implantable electrical medical device includes (i) electronics configured to generate or receive an electrical signal and containing a plurality of channels through which the electrical signal may be transmitted; (ii) a first lead receptacle having a first defined number of internal contacts, wherein each of the internal contacts are independently operably coupled to a discrete channel of the electronics; and (iii) a second lead receptacle having a second defined number of internal contacts, wherein the second defined number is less than the first defined number, and wherein each of the internal contacts of the second receptacle are independently operably coupled to a discrete channel of the electronics. At least one of the internal contacts of the first lead receptacle and at least one of the internal contacts of the second lead receptacle are operably coupled to the same channel of the electronics.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: December 20, 2016
    Assignee: Medtronic, Inc.
    Inventor: Dale F. Seeley
  • Patent number: 9517351
    Abstract: Methods and apparatuses for amplitude modulation of all or a portion of an ensemble waveform to modify a user's cognitive state by transdermal electrical stimulation (TES). An ensemble current waveform may include a sequence of component biphasic current waveforms in which one or more parameters (such as frequency, current amplitude, percent duty cycle, and percent charge imbalance) vary between sequential component waveforms. These ensemble waveforms may be specifically configured to evoke a particular cognitive state when applied by TES. In particular, described herein are methods for applying amplitude modulation to all or a sub-set of the component waveforms in the ensemble waveform which may dramatically enhance the efficiency and effectiveness of the TES. Also described herein are methods and apparatuses for applying amplitude modulation to all or a portion of an ensemble waveform without truncating pulses of the component waveforms forming the ensemble waveform.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: December 13, 2016
    Assignee: Thyne Global, Inc.
    Inventors: Jonathan Charlesworth, Sumon K. Pal
  • Patent number: 9517347
    Abstract: An implantable pulse generator (IPG) that generates spinal cord stimulation signals for a human body includes an electrode driver for each electrode, which adjusts the amplitude of the timing signals and output an output current corresponding to the adjusted signals for transmission to the associated electrode so as to enable independent amplitude control of the stimulation signals for each stimulation pattern channel.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 13, 2016
    Assignee: GLOBUS MEDICAL, INC.
    Inventors: Christopher Biele, Raghavendra Angara, Saif Khalil
  • Patent number: 9492667
    Abstract: Systems and methods to control non-paresthesia stimulation of nerve tissue of a patient are herein disclosed. The systems and methods deliver a non-paresthesia stimulation waveform to at least one electrode proximate to target nerve fibers, and define an analysis window that is positioned to occur at an intermediate point within at least one of a first burst or an inter-burst delay. Additionally, the systems and methods, during the analysis window, measure evoked potential (EP) signals from the target nerve fibers. The systems and methods also analyze the EP signals to obtain activity data for select nerve fiber components, and adjust at least one therapy parameter to change the non-paresthesia stimulation waveform based on the activity data.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: November 15, 2016
    Assignee: Pacesetter, Inc.
    Inventors: Alexander Kent, Edward Karst, Gene A. Bornzin
  • Patent number: 9440083
    Abstract: A process, method, and devices thereof for the rapid destruction of cancer tumor(s) which are made up of thousands to millions of living malignant cancer cells. Such an approach seeks to kill said tumor(s) by causing apoptosis or excitotoxicity and/or osmotic-shock within a human or animal for medical treatment.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: September 13, 2016
    Assignee: Neuro Code Tech Holdings, LLC
    Inventor: Eleanor L. Schuler
  • Patent number: 9327123
    Abstract: Endovascular nerve monitoring devices and associated systems and methods are disclosed herein. A nerve monitoring system configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion and a distal portion and a nerve monitoring assembly at the distal portion. The shaft is configured to locate the distal portion intravascularly at a treatment site. The nerve monitoring assembly can include a bipolar stimulation electrode array and a bipolar recording electrode array disposed distal to the bipolar stimulation electrode assembly.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: May 3, 2016
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Dwayne S. Yamasaki, Bryan Courtney, Wenjeng Li, Kevin Mauch, Kevin McFarlin, Gabriel Brennan, David Gannon, David Hobbins, Brian Kelly, Stephen Nash, Matthew Bonner, Sean Ward
  • Patent number: 9320910
    Abstract: An implantable pulse generator (IPG) is fabricated by utilizing a lead body with a plurality of conductors enclosed in insulative material along a first length of the conductors, and a second length of the conductors being exposed. A tubular structure is placed over the lead body with the plurality of conductors extending through it. A feedthrough assembly includes a plurality of feedthrough pins surrounded by insular material with a ferrule extending about an outer surface of the feedthrough assembly. The plurality of conductors are attached to the plurality of feedthrough pins and the ferrule of the feedthrough assembly is welded to the tubular structure to form an intermediate assembly. The intermediate assembly is then welded to one or more housing components of the IPG providing a hermetically seal. A connector portion on a distal end of the lead body is provided to electrically connect to terminals of a stimulation lead.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: April 26, 2016
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Ken McGiboney, Galen L. Smith, Michael Gaines, Jerome Boogaard
  • Patent number: 9314628
    Abstract: A fully automated computer controlled system is provided for adjustment of neurostimulation implants used in pain therapy and in treating neurological dysfunction which includes a patient interactive computer, and a universal transmitter interface integrally embedded in the patient interactive computer or built into the antenna which is capable of stimulating any type of implanted neurostimulation devices by imitating programming codes. The patient interacts with the system through the patient interactive computer. The universal transmitter interface includes a direct digital synthesizer, a transistor circuitry driving the antenna in ON-OFF fashion and a gating unit for driving the transistor circuitry under control of the processing means in the patient-interactive computer. Alternatively, the universal transmitting interface includes a balanced modulator for modulation of the carrier signal generated at the direct digital synthesizer.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: April 19, 2016
    Assignee: Medtronic, Inc.
    Inventors: Richard Boydston North, Jeffrey Mark Sieracki, Kim Randal Fowler, Lon Hodges Holland