Pulse Signal Patents (Class 607/72)
  • Patent number: 10682509
    Abstract: The present invention relates to a device for providing neuromuscular stimulation. The device comprises a positive electrode, a plurality of negative electrodes, a non-conductive substrate and a control unit for activating the electrodes. The control unit of the device activates the negative electrodes in a predetermined sequence, so as to deliver electrical stimulus to a user, wherein the predetermined sequence is repeated with an increasing level of stimulus until a predetermined outcome is achieved. Additionally each negative electrode of the devices comprises at least one conductive track mounted on the non-conductive substrate wherein at least one pair of negative electrodes overlap such that the conductive track or tracks of a first negative electrode of the pair overlap with the electrode footprint, but not the conductive tracks, of a second negative electrode of the pair.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 16, 2020
    Assignee: Sky Medical Technology Ltd
    Inventors: Jonathan Fenton, Duncan Bain, Martin Gordon, Benjamin Gordon
  • Patent number: 10646164
    Abstract: A wirelessly powered implantable stimulator device includes one or more antenna configured to receive an input signal non-inductively from an external antenna, the input signal containing (i) electrical energy to operate the implantable stimulator device and (ii) configuration data according to which a pulse-density modulation (PDM) encoded stimulus waveform signal is retrieved to synthesize a desired stimulation waveform; a circuit coupled to the one or more antenna; and one or more electrodes coupled to the circuit and configured to apply the desired stimulation waveform to neural tissue, wherein the circuit is configured to: rectify the input signal received at the one or more antennas non-inductively; extract the electrical energy and the configuration data from the input signal; and in accordance with the extracted configuration data, retrieve the pulse-density modulation (PDM) signal to synthesize the desired stimulation waveform therefrom.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: May 12, 2020
    Assignee: Stimwave Technologies Incorporated
    Inventors: Laura Tyler Perryman, Bertan Bakkaloglu, Chad David Andresen
  • Patent number: 10617880
    Abstract: A system and method for powering a medical device that includes a fixture configured for periodic patient proximity; external electrical coupling device integrated into the fixture wherein the external electrical coupling device comprises at least one external energy coupler and is configured to detect presence of an electrical medical device implant in a transmission zone of the external electrical coupling device; an electrical medical device implant, wherein the electrical medical device implant comprises at least one implant energy coupler; and wherein the external electrical coupling device is configured to couple to the implantable medical device through a wireless energy transmission between the external energy coupler and the implant energy coupler when presence of the implantable medical device is within a transmission zone.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 14, 2020
    Assignee: Intelligent Implants Limited
    Inventors: Erik Zellmer, John Zellmer, Rory Murphy
  • Patent number: 10593231
    Abstract: A system for monitoring stomach fullness includes an ultrasound transponder configured to transmit ultrasound signals and receive reflected ultrasound signals. A processor is configured to process the received reflected ultrasound signals to determine level of stomach fullness and output fullness data indicative of the determined level of stomach fullness. A memory stores calibration data representative of calibrated levels of stomach fullness including empty and full. A stored program has executable codes to, upon execution, control the ultrasound transponder, compare the fullness data against the calibration data, and output alert data upon a match of a preset fullness level.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: March 17, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Amos Cahan, Theodore Gerard Van Kessel
  • Patent number: 10518088
    Abstract: The invention comprises SCENAR-therapy or other methods of electric stimulation, where an inductive energy storage unit is used to generate stimuli, and can be applied for therapeutic, rehabilitation, research, and preventive purposes. The invention includes applying electrodes on tissues and transmitting through them bursts of electrical stimuli. The stimuli are controlled based on processes occurring in these tissues as a result of their interaction with the electrical stimuli. The exposure duration and/or stimuli parameters are controlled according to the free oscillation parameters. The invention includes three types of parameter measurements: measuring parameters while the current stimulus burst is acting; measuring parameters of the last stimulus of each burst; and generating a probing sole stimulus before the main burst and measuring parameters of this stimulus.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: December 31, 2019
    Assignee: RITM OKB ZAO
    Inventors: Yakov Zalmanovich Grinberg, Yury Yurievich Starovoytov, Mikhail Anatolievich Unakafov
  • Patent number: 10485971
    Abstract: A system and method for the transcutaneous stimulation of various nerves such as the phrenic, hypoglossal, and vagal nerves is provided. The stimulation elicits a corresponding muscle response without reported pain.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 26, 2019
    Assignee: Avent, Inc.
    Inventors: Eric A. Schepis, Carolyn Y. Sargent
  • Patent number: 10485605
    Abstract: An apparatus and method stimulate or sense neurons or groups of neurons in a subject, e.g., a human or animal brain, with positional dependence. This utility is provided in part by utilizing individually-addressable Radio-Frequency IDentification (RFID) coils so that locations of those coils in the brain would be monitored and known.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: November 26, 2019
    Assignee: Weinberg Medical Physics, Inc.
    Inventor: Irving N. Weinberg
  • Patent number: 10449355
    Abstract: A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include one or more electrode leads coupled to an implantable pulse generator (IPG) and a tunneler system for subcutaneously implanting a proximal portion of the lead(s). The system may also include a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: October 22, 2019
    Assignee: Mainstay Medical Limited
    Inventors: John Beck, Jason Skubitz, Peter Crosby, Henry DeMorett, Jason Alan Shiroff
  • Patent number: 10426945
    Abstract: Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: October 1, 2019
    Assignee: Thync Global, Inc.
    Inventors: William J. Tyler, Wing Law, Douglas Jeffery, Rafal Piersiak
  • Patent number: 10420939
    Abstract: Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. Methods include placing an electrical lead in electrical communication with the injured or damaged nerve. Methods further include temporarily stimulating the nerve and/or applying sub-threshold stimulation to the nerve to promote neuroregeneration of the nerve. The nerve can be a peripheral nerve.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: September 24, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Bradley C. Gill, Yaw A. Nyame, Eric A. Klein
  • Patent number: 10232178
    Abstract: Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: March 19, 2019
    Assignee: Electrocore, Inc.
    Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
  • Patent number: 10207109
    Abstract: A neuromodulation system comprises electrical terminals configured for being respectively coupled to electrodes. The system further comprises modulation output circuitry configured for respectively outputting individual electrical pulse trains in timing channels to the electrical terminals, wherein each of the pulse trains has a modulation pulse, and at least one of the pulse trains has a charge recovery pulse associated with the modulation pulse of the respective pulse train. The neuromodulation system further comprises control circuitry configured for controlling the modulation output circuitry in a manner that sequentially outputs the modulation pulses of the respective pulse trains to a common set of the electrical terminals without an intervening charge recovery pulse, and outputting the charge recovery pulse(s) to the common set of the electrical terminals subsequent to the sequential modulation pulses, thereby creating a combined electrical pulse train at the common set of electrical terminals.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: February 19, 2019
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Changfang Zhu, Que T. Doan
  • Patent number: 10201706
    Abstract: Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject's inflammatory disorder.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: February 12, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Jan Schwab, Phillip Popovich, Ali R. Rezai
  • Patent number: 10183163
    Abstract: Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system for controlling a therapy provided to a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The operational instruction defines at least one of a pulse duration, a pulse frequency, a pulse number, and a pulse amplitude. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: January 22, 2019
    Assignee: The General Hospital Corporation
    Inventors: Alexander Golberg, Martin L. Yarmush, Robert L. Sheridan, William Gerald Austen, G. Felix Broelsch, Boris Rubinsky, Michael Belkin
  • Patent number: 10172663
    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: January 8, 2019
    Assignee: Ablative Solutions, Inc.
    Inventors: David R. Fischell, Tim A. Fischell
  • Patent number: 10159420
    Abstract: A nerve impulse signal stimulation device and a method for fabricating the same are provided. The nerve impulse signal stimulation device includes: a substrate having a first surface and a second surface opposite to the first surface; a first metal layer formed on the first surface of the substrate; a second metal layer formed on the first metal layer; a plurality of openings exposing a portion of the first surface of the substrate, a portion of the first metal layer and a portion of the second metal layer; and a ferromagnetic material attached to the second surface of the substrate. The openings cause the nerve impulse signal stimulation device to obtain a parallel circuit structure, thereby increasing the current load and the magnetic field intensity, reducing the size of the device, and ensuring the safety of operations.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: December 25, 2018
    Assignee: National Chiao Tung University
    Inventors: Yu-Ting Cheng, Chung-Yu Wu, Jui-Sheng Sun, Yu-Min Fu, Che-Yu Chen, Xin-Hong Qian
  • Patent number: 10112050
    Abstract: A neuromodulation system and method of providing sub-threshold therapy to a patient. An anodic perception threshold of super-threshold electrical energy and a cathodic perception threshold of super-threshold electrical energy are determined for a plurality of electrode sets. A ratio between the anodic perception threshold and the cathodic perception threshold is calculated for each of the electrode sets. An effective electrode set is selected based on the ratio between the anodic perception threshold and the cathodic perception threshold.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 30, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Dongchul Lee, Changfang Zhu
  • Patent number: 10092758
    Abstract: A method is provided to deliver C tactile fiber stimulation to nervous tissue of a patient. The method comprises delivering a first tactile stimulation waveform to a first electrode combination within an array of electrodes located proximate to nervous tissue of interest. The method further provides sequentially delivering successive tactile stimulation waveforms to successive electrode combinations within the array of electrodes. The first and successive tactile stimulation waveforms include at least one series of pulses having a pulse amplitude and pulse frequency. Delaying delivery of the successive tactile stimulation waveforms by a firing delay, the pulse amplitude, pulse frequency and firing delay represent therapy parameters. The method manages at least one of the therapy parameters of the first and successive tactile stimulation waveforms to excite C tactile fibers of the nervous tissue of interest.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 9, 2018
    Inventor: Dirk De Ridder
  • Patent number: 10086198
    Abstract: A bioelectric signal generation and application method generates a signal that comprises a succession of pulses arranged either in continuous trains or in separated bursts; in which each pulse within a train or burst comprises at least three distinct intervals of time; in which the first said interval of time has one definite polarity and sufficient current density and duration to cause motion of calcium ions (Ca++) in relation to less strongly charged components of a body, cell or tissue, such as proteins and especially the protein calmodulin (CaM); in which the second said interval of time has substantially zero current density and is of sufficient duration to allow any proteins or other molecules which became distorted by electric fields present during said first interval, and especially CaM, to relax back into their normal, undistorted shapes, said first and second intervals of time thus comprising a “two-step electric process.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: October 2, 2018
    Assignee: APOGEE MEDICAL, LLC
    Inventor: James W Kronberg
  • Patent number: 9981134
    Abstract: A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to electrodes, modulation output circuitry configured for respectively outputting a plurality of individual electrical pulse trains in a plurality of timing channels to the electrical terminals, wherein each of the timing channels prevents the respective pulse train from having a specific characteristic, and control circuitry configured for controlling the modulation output circuitry in a manner that outputs the pulse trains to a common set of the electrical terminals, thereby creating a combined electrical pulse train at the common set of electrical terminals that has the specific characteristic. A method of providing therapy to a patient comprises delivering a plurality of electrical pulse trains respectively in a plurality of timing channels to a common set of electrodes implanted within the patient, thereby creating a combined electrical pulse train at the common set of electrical terminals.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 29, 2018
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Que T. Doan, Changfang Zhu
  • Patent number: 9950174
    Abstract: An implantable pulse generator (IPG) that generates spinal cord stimulation signals for a human body includes a timing generator and high frequency generator. The timing generator generates timing signals that represent stimulation signals for multiple channels. The high frequency generator determines whether to modulate the timing signals and modulates them at a burst frequency according to stored burst parameters if the decision is yes. As such, the IPG provides the ability to generate both the low frequency and high frequency stimulation signals in different channels according to user programming.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 24, 2018
    Assignee: GLOBUS MEDICAL, INC.
    Inventors: Christopher Biele, Raghavendra Angara, Saif Khalil
  • Patent number: 9937353
    Abstract: According to an embodiment of a method performed by an implantable medical device to deliver a neural stimulation therapy to a patient, a lower dose of the neural stimulation therapy is delivered to the patient. The dose of the neural stimulation therapy is automatically increased from the lower dose to a higher dose, and the higher dose of the neural stimulation therapy is delivered to the patient. A trigger that is controlled by the patient is detected, and the dose of the neural stimulation therapy is automatically returned from the higher dose back to the lower dose in response to detecting the trigger.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: April 10, 2018
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Stephen J. Hahn, Jason J. Hamann, David J. Ternes
  • Patent number: 9867937
    Abstract: A portable infusion pump can communicate with glucose monitor, such as a continuous glucose monitor (CGM), to receive continuous feedback relating to a user's blood glucose level during insulin or other medicament therapy and can automatically deliver insulin to a user when the CGM data indicates a need for additional insulin. Due to potential unreliability in the correlation of the CGM data to the user's actual blood glucose level, risk mitigation can be employed to limit the amount of extra insulin that can be delivered by the pump in response to the CGM data.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: January 16, 2018
    Assignee: Tandem Diabetes Care, Inc.
    Inventors: Sean Saint, Michael Rosinko
  • Patent number: 9844676
    Abstract: Techniques for facilitating communication between an implantable device and an external device are provided. In one example, an implantable device includes a data packet component and a communication component. The data packet component can insert information associated with the implantable device in a defined service field of an advertising data packet. The defined service field can be selected from one or more service fields of the advertising data packet based on the information associated with the implantable device. The communication component can transmit the advertising data packet. The external device can include a scanning component that can scan one or more service fields of the advertising data packet via an advertising communication channel, and a communication component that can establish a communication link with the implantable device in response to a determination that a criterion associated with a service field is satisfied.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: December 19, 2017
    Assignee: Medtronic, Inc.
    Inventors: Bo Zhang, Matthew R. Yoder
  • Patent number: 9775995
    Abstract: The invention provides the use of electrical pulses (I, W) to reduce, improve, heal or prevent recurrence of a chronic ulcer, comprising administering to a need (1, 2, 3) an effective amount of an electric stimulation in multiple treatment sessions, wherein the electric stimulation stimulates the lymphatic system.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: October 3, 2017
    Assignee: BODYFLOW INTERNATIONAL PTY LTD ACN
    Inventor: Joe Di Santo
  • Patent number: 9770598
    Abstract: A connector for an implantable electrical medical device includes a connector lumen defined in an elongated connector housing and adapted for receiving a portion of a lead. Connector-contact assemblies are disposed in the connector lumen and adapted to couple to terminals of the lead when the lead is received by the connector lumen. Each of the connector-contact assemblies includes a contact body. An inner surface of the contact body defines an open center portion. A first base is disposed along a first end of the contact body, and a second base is disposed along an opposing second end of the contact body and is coupled to the first base. Biasing members are attached to the first base and extend towards the second base. The biasing members are not attached to the second base. When the lead is received by the connector lumen the biasing members physically contact the received lead.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: September 26, 2017
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Zdzislaw Bernard Malinowski, Jeffery Van Funderburk
  • Patent number: 9522281
    Abstract: An implantable electrical medical device includes (i) electronics configured to generate or receive an electrical signal and containing a plurality of channels through which the electrical signal may be transmitted; (ii) a first lead receptacle having a first defined number of internal contacts, wherein each of the internal contacts are independently operably coupled to a discrete channel of the electronics; and (iii) a second lead receptacle having a second defined number of internal contacts, wherein the second defined number is less than the first defined number, and wherein each of the internal contacts of the second receptacle are independently operably coupled to a discrete channel of the electronics. At least one of the internal contacts of the first lead receptacle and at least one of the internal contacts of the second lead receptacle are operably coupled to the same channel of the electronics.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: December 20, 2016
    Assignee: Medtronic, Inc.
    Inventor: Dale F. Seeley
  • Patent number: 9517347
    Abstract: An implantable pulse generator (IPG) that generates spinal cord stimulation signals for a human body includes an electrode driver for each electrode, which adjusts the amplitude of the timing signals and output an output current corresponding to the adjusted signals for transmission to the associated electrode so as to enable independent amplitude control of the stimulation signals for each stimulation pattern channel.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 13, 2016
    Assignee: GLOBUS MEDICAL, INC.
    Inventors: Christopher Biele, Raghavendra Angara, Saif Khalil
  • Patent number: 9517351
    Abstract: Methods and apparatuses for amplitude modulation of all or a portion of an ensemble waveform to modify a user's cognitive state by transdermal electrical stimulation (TES). An ensemble current waveform may include a sequence of component biphasic current waveforms in which one or more parameters (such as frequency, current amplitude, percent duty cycle, and percent charge imbalance) vary between sequential component waveforms. These ensemble waveforms may be specifically configured to evoke a particular cognitive state when applied by TES. In particular, described herein are methods for applying amplitude modulation to all or a sub-set of the component waveforms in the ensemble waveform which may dramatically enhance the efficiency and effectiveness of the TES. Also described herein are methods and apparatuses for applying amplitude modulation to all or a portion of an ensemble waveform without truncating pulses of the component waveforms forming the ensemble waveform.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: December 13, 2016
    Assignee: Thyne Global, Inc.
    Inventors: Jonathan Charlesworth, Sumon K. Pal
  • Patent number: 9492667
    Abstract: Systems and methods to control non-paresthesia stimulation of nerve tissue of a patient are herein disclosed. The systems and methods deliver a non-paresthesia stimulation waveform to at least one electrode proximate to target nerve fibers, and define an analysis window that is positioned to occur at an intermediate point within at least one of a first burst or an inter-burst delay. Additionally, the systems and methods, during the analysis window, measure evoked potential (EP) signals from the target nerve fibers. The systems and methods also analyze the EP signals to obtain activity data for select nerve fiber components, and adjust at least one therapy parameter to change the non-paresthesia stimulation waveform based on the activity data.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: November 15, 2016
    Assignee: Pacesetter, Inc.
    Inventors: Alexander Kent, Edward Karst, Gene A. Bornzin
  • Patent number: 9440083
    Abstract: A process, method, and devices thereof for the rapid destruction of cancer tumor(s) which are made up of thousands to millions of living malignant cancer cells. Such an approach seeks to kill said tumor(s) by causing apoptosis or excitotoxicity and/or osmotic-shock within a human or animal for medical treatment.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: September 13, 2016
    Assignee: Neuro Code Tech Holdings, LLC
    Inventor: Eleanor L. Schuler
  • Patent number: 9327123
    Abstract: Endovascular nerve monitoring devices and associated systems and methods are disclosed herein. A nerve monitoring system configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion and a distal portion and a nerve monitoring assembly at the distal portion. The shaft is configured to locate the distal portion intravascularly at a treatment site. The nerve monitoring assembly can include a bipolar stimulation electrode array and a bipolar recording electrode array disposed distal to the bipolar stimulation electrode assembly.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: May 3, 2016
    Assignee: Medtronic Ardian Luxembourg S.a.r.l.
    Inventors: Dwayne S. Yamasaki, Bryan Courtney, Wenjeng Li, Kevin Mauch, Kevin McFarlin, Gabriel Brennan, David Gannon, David Hobbins, Brian Kelly, Stephen Nash, Matthew Bonner, Sean Ward
  • Patent number: 9320910
    Abstract: An implantable pulse generator (IPG) is fabricated by utilizing a lead body with a plurality of conductors enclosed in insulative material along a first length of the conductors, and a second length of the conductors being exposed. A tubular structure is placed over the lead body with the plurality of conductors extending through it. A feedthrough assembly includes a plurality of feedthrough pins surrounded by insular material with a ferrule extending about an outer surface of the feedthrough assembly. The plurality of conductors are attached to the plurality of feedthrough pins and the ferrule of the feedthrough assembly is welded to the tubular structure to form an intermediate assembly. The intermediate assembly is then welded to one or more housing components of the IPG providing a hermetically seal. A connector portion on a distal end of the lead body is provided to electrically connect to terminals of a stimulation lead.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: April 26, 2016
    Assignee: Advanced Neuromodulation Systems, Inc.
    Inventors: Ken McGiboney, Galen L. Smith, Michael Gaines, Jerome Boogaard
  • Patent number: 9314628
    Abstract: A fully automated computer controlled system is provided for adjustment of neurostimulation implants used in pain therapy and in treating neurological dysfunction which includes a patient interactive computer, and a universal transmitter interface integrally embedded in the patient interactive computer or built into the antenna which is capable of stimulating any type of implanted neurostimulation devices by imitating programming codes. The patient interacts with the system through the patient interactive computer. The universal transmitter interface includes a direct digital synthesizer, a transistor circuitry driving the antenna in ON-OFF fashion and a gating unit for driving the transistor circuitry under control of the processing means in the patient-interactive computer. Alternatively, the universal transmitting interface includes a balanced modulator for modulation of the carrier signal generated at the direct digital synthesizer.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: April 19, 2016
    Assignee: Medtronic, Inc.
    Inventors: Richard Boydston North, Jeffrey Mark Sieracki, Kim Randal Fowler, Lon Hodges Holland
  • Patent number: 9254382
    Abstract: An electro-acupuncture device for controlling over active bladder is described. The device includes a housing, circuitry for generating electro-acupuncture stimulus disposed within the housing, and at least one strap for securing the housing to the ankle. The device also includes a pair of D-shaped electrodes received within the bottom outer surface of the housing. The housing of the device is flexible with a low profile and is shaped so that it is conformal to a person's ankle. When the device is strapped to a patient's ankle, the electrodes contact the ankle and provide electric stimulation to the tibial nerve within the ankle.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: February 9, 2016
    Assignee: ReliefBand Technologies LLC
    Inventors: Aftab Ahmad, Matthew J. Geary, Farhan Hussain
  • Patent number: 9246041
    Abstract: An apparatus and method for allowing avalanche photodiode based single-photon detectors to be driven by the same electrical circuit in gated and in free-running modes is proposed. The high-performance working of all the running modes relies on the capability of tuning the rise-time value of the electrical pulse driver which activates the avalanche photodiode in Geiger mode.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: January 26, 2016
    Assignee: ID QUANTIQUE SA
    Inventors: Bernard Clausen, Laurent Monat, Alexis Rochas
  • Patent number: 9216287
    Abstract: According to one embodiment of the present invention, an apparatus for measuring and treating dysphagia may comprise: one or more dysphagia measuring sensor units attached to the neck of a patient; one or more electrical stimulation electrode units attached to the neck of the patient to provide electrical stimulation to the neck of the patient in accordance with the dysphagia signal sensed by the dysphagia measuring sensor units so as to resolve the dysphagia; and a control unit which controls the dysphagia measuring sensor units and the electrical stimulation electrode units.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: December 22, 2015
    Assignees: POSTECH ACADEMY-INDUSTRY FOUNDATION, SAMSUNG LIFE WELFARE FOUNDATION
    Inventors: Heecheon You, Baekhee Lee, Kihyo Jung, Giltae Yang, Saewon Hong, Duk Lyul Na, Youngho Lee
  • Patent number: 9089690
    Abstract: The present invention is an implantable electrode array having electrodes with variable pitch and variable size. Electrode arrays of the prior art provide electrodes with a common spacing and size. However, this is not how the human body is arranged. As an example, the retina has closely spaced retinal receptors near the fovea. Those receptors are spaced farther apart, farther away from the fovea. Further, the amount of electrical current required to stimulate the perception of light increases with distance from the fovea. Hence, larger electrodes are required to transfer the necessary current farther away from the fovea.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: July 28, 2015
    Assignee: Second Sight Medical Products, Inc.
    Inventors: Robert Greenberg, Richard Williamson, Mark Humayan
  • Patent number: 9089691
    Abstract: Devices and methods to stimulate the auricular branch of the vagus nerve are provided. Various device embodiments comprise a lead, a neural stimulation circuit, and a controller. The lead has a neural stimulation electrode. The neural stimulation circuit is connected to the lead to deliver a neural stimulation signal adapted to stimulate the auricular nerve branch using the neural stimulation electrode. The controller is connected to the neural stimulation circuit and is adapted to control delivery of the neural stimulation signal from the neural stimulation circuit to provide a vagal stimulation therapy. In various embodiments, the electrode is adapted to be placed in an external auditory canal. In various embodiments, the electrode includes a transcutaneous neural stimulation electrode adapted to be placed behind an ear.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: July 28, 2015
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Imad Libbus, Julia Moffitt
  • Patent number: 9056197
    Abstract: Devices, systems and methods are provided for targeted treatment of a variety of conditions, particularly conditions that are associated with or influenced by the nervous system, such as pain. Targeted treatment of such conditions is provided with minimal deleterious side effects, such as undesired motor responses or undesired stimulation of unaffected body regions. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: June 16, 2015
    Assignee: Spinal Modulation, Inc.
    Inventors: Eyad Kishawi, Mir A. Imran, Brian J. Mossop, Jeffery M. Kramer, Richard W. O'Connor
  • Publication number: 20150148862
    Abstract: The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
  • Publication number: 20150127066
    Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Inventors: Warren M. Grill, JR., Alan D. Dorval, II, Robert Strother
  • Publication number: 20150127068
    Abstract: Devices, systems and methods for applying electrical impulse(s) to one or more selected nerves are described. An electrical stimulator is introduced through a to a target location within, adjacent to, or in close proximity with, the carotid sheath. The stimulator has an antenna that allows it to be powered solely by far-field or approximately plane wave electromagnetic radiation, having frequencies in the range of 0.3 to 10 GHz. Electrical impulses are applied through the stimulator to a vagus nerve to stimulate, block or otherwise modulate activity of the nerve and treat the patient's condition. The stimulator uses an adjustable number of fixed voltage (or fixed current) pulses with fixed duration to elicit desired changes in nerve response, the timing of which are controlled by an external power transmitter and controller.
    Type: Application
    Filed: November 4, 2013
    Publication date: May 7, 2015
    Applicant: ElectroCore, LLC
    Inventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
  • Patent number: 9026226
    Abstract: An implantable medical electrical lead for electrical stimulation of body tissue that includes at least one shape memory polymer portion that has a first configuration and a second configuration, wherein the second configuration is obtained upon exposure of the shape memory polymer portion to a transition stimulus, and wherein the second configuration of the modifiable portion exhibits a greater resistance to movement of the lead within the body tissue than does the first configuration; and at least one electrode configured to provide electrical stimulation of body tissue, wherein the lead has a proximal end and a distal end. Systems and kits as well as methods of utilizing the leads of the invention are also included.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: May 5, 2015
    Assignee: Medtronic, Inc.
    Inventors: Martin T. Gerber, Eric H. Bonde
  • Publication number: 20150112409
    Abstract: The present method and system provides for the clinical application of neurostimulation and/or neuromodulation to a patient. The method and system includes receipt and acquisition of patient data, processing of that data relative to one or more known data sets, and determination of a good-fit trigger specific treatment protocol. The method and system provides for application of the protocol to the patient, including delivery of neuromodulation and biofeedback. Based thereon, the method and system re-iterates the goodness of fit determination for further treatment to the patient.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 23, 2015
    Inventor: David W Hagedorn
  • Patent number: 9002472
    Abstract: Methods, apparatuses, and software for operating such apparatuses, for neuromodulation in a live mammalian subject, such as a human patient, provide for applying electrical energy to a target site in the nervous system of the subject using a signal comprising a series of pulses, wherein the inter-pulse intervals are varied using the output of a deterministic, non-linear, dynamical system comprising one or more system control parameters. In certain embodiments, the target site may be a site in the brain involved in generalized CNS (central nervous system) arousal. The dynamical system may be capable of exhibiting chaotic behavior.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: April 7, 2015
    Assignees: Intelect Medical, Inc., The Rockefeller University
    Inventors: Scott Kokones, Bradford Curtis Fowler, Donald Pfaff, Amy Wells Quinkert
  • Publication number: 20150094645
    Abstract: The invention relates to an apparatus for application of a pulsed radio frequency therapy in a vascular system or another cavity or tissue of the human or animal body comprising a catheter with at least one electrode disposed thereon for insertion into the vascular system or another cavity or the tissue of the human or animal body; a probe with at least one further electrode disposed thereon, wherein the probe is insertable via the catheter into the vascular system or the other cavity or the tissue of the human or animal body; and a generator electrically connected with the electrodes for generating a pulsed electro-magnetic field between the electrodes.
    Type: Application
    Filed: August 14, 2012
    Publication date: April 2, 2015
    Inventor: Omar Omar-Pasha
  • Patent number: 8996137
    Abstract: Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: March 31, 2015
    Assignee: Oculeve, Inc.
    Inventors: Douglas Michael Ackermann, James Donald Loudin, John Wardle, Jarren Armond Baldwin, Daniel N. Hamilton, Janusz Kuzma, Christopher William Stivers
  • Publication number: 20150073495
    Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
    Type: Application
    Filed: November 17, 2014
    Publication date: March 12, 2015
    Inventors: Warren M. Grill, JR., Alan D. Dorval, II
  • Publication number: 20150073512
    Abstract: An implantable device (11) for evaluating autonomic cardiovascular drive in a patient (10) suffering from chronic cardiac dysfunction is provided. A stimulation therapy lead (13) includes helical electrodes (14) configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins (28) electrically connected to the helical electrodes (14). A neurostimulator (12) includes an electrical receptacle (25) into which the connector pins (28) are securely and electrically coupled. The neurostimulator (12) also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes (14) in alternating cycles of stimuli application and stimuli inhibition (90) that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator (12) includes a recordable memory (29) storing a baseline heart rate.
    Type: Application
    Filed: November 13, 2014
    Publication date: March 12, 2015
    Inventors: Imad Libbus, Badri Amurthur, Bruce H. KenKnight