Internal Application Patents (Class 607/92)
  • Patent number: 11173320
    Abstract: A device is presented for use in treatment of tissues inside a body cavity. The device comprises a probe member having at least a portion thereof carrying a plurality of light sources, at least said portion of the probe member having dimensions and shape suitable for insertion into a certain body cavity and for arranging within the surface thereof a three-dimensional array of said light sources, the light sources being configured and operable to irradiate optical energy outwardly from said probe member.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: November 16, 2021
    Inventor: Esther Mayer
  • Patent number: 11147984
    Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: October 19, 2021
    Assignee: KNOW Bio, LLC
    Inventors: David T. Emerson, Michael John Bergmann, Thomas Matthew Womble, Antony Paul van de Ven, Nathan Stasko, F. Neal Hunter, Adam Cockrell, Rebecca McDonald
  • Patent number: 11141602
    Abstract: An implantable phototherapy device includes a power receiver element configured to receive power from an external power transmitter, a light delivery element powered by the power receiver, and configured to deliver phototherapy to a target treatment area, and a tether element is coupled to the light delivery element and the power receiver element. The tether element is configured to deliver power between the power receiver element and the light delivery element.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: October 12, 2021
    Assignee: INCANDO THERAPEUTICS PTE. LTD.
    Inventors: Percy Luu, Cheng-Wei Pei, James Marshall Robinson
  • Patent number: 10512787
    Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: December 24, 2019
    Assignee: Circuit Therapeutics, Inc.
    Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
  • Patent number: 10220221
    Abstract: A dental device for treating dental infection includes a dental cast comprising at least one groove to receive teeth and/or gums of a dental arch of the patient; and at least one light diffusing fiber arranged on the dental cast around the at least one groove. The dental device is used in a photodynamic therapeutic system, in which a light source instrument emits light onto a photosensitizer applied in mouth of the patient. The dental device is optically coupled to the light source instrument. The light for treating dental infection of the patient is transmitted by the at least one light diffusing fiber of the dental device and activates the photosensitizer to produce free radicals or oxidants to destroy the bacteria and microbes causing dental disease.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: March 5, 2019
    Assignee: Olighter Co., Ltd.
    Inventor: Ping-Ching Wu
  • Patent number: 10213544
    Abstract: A method for performing a photopheresis procedure is provided comprising collecting MNCs in a suspension comprising RBCs and plasma and lysing the red blood cells in the solution, preferably by combining the suspension with a solution to cause lysis. In one example, the solution for causing lysis of the red blood cells comprises ammonium chloride, and the suspension including the ammonium chloride is incubated to cause lysing. After lysing, the suspension may be washed to remove plasma and hemoglobin freed by the lysis of the red blood cells, and an ultraviolet light activated substance is added to the suspension. The suspension is then irradiated with ultraviolet light.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: February 26, 2019
    Assignee: Fenwal, Inc.
    Inventor: Katherine Radwanski
  • Patent number: 10213617
    Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: February 26, 2019
    Assignee: Circuit Therapeutics, Inc.
    Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
  • Patent number: 9926359
    Abstract: This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain embodiments, the disclosure relates to treating or preventing epilepsy or seizures comprising administering an effective amount of a vector that encodes an opsin and luciferase in combination with a luciferin to a subject in need thereof.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: March 27, 2018
    Assignee: Emory University
    Inventors: Robert E. Gross, Nealan G. Laxpati, Jack Tung, Ken Berglund
  • Patent number: 9364683
    Abstract: The portable electronic device includes radiation elements (104A, 104B) for directing optical radiation energy non-invasively at intracranial nerve tissue of a user through an external auditory canal of the user of the portable electronic device to stimulate the user's intracranial nerve tissue. Stimulation may have a metabolic and/or nervous response, which appears as a change in alertness, diurnal rhythm and in concentrations of several hormones and brain transmitters.
    Type: Grant
    Filed: September 5, 2007
    Date of Patent: June 14, 2016
    Assignee: Valkee OY
    Inventors: Juuso Nissilä, Antti Aunio
  • Patent number: 9192314
    Abstract: In various embodiments, a probe includes at least one shank, optical components disposed within the shank for transmitting light into a sample and collecting light from the sample, and electrical components disposed within the shank for recording an electrical signal from the sample. In certain embodiments, a method includes collecting light from the sample using a first shank of the probe, recording an electrical signal from the sample using a second shank of the probe, and analyzing the collected light and the electrical signal.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: November 24, 2015
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Bryan McLaughlin, John LeBlanc
  • Patent number: 9044595
    Abstract: A system is provided for reducing lipid content of adipocytes in a body. The system includes an optical device configured to illuminate a region of the body at a selective peak wavelength and at a selective power density for a selective time period. The system also includes a controller connected to the optical device to determine the selective wavelength, the selective power density and the selective time period to stimulate lipolysis in the adipocytes. A system is also provided for reducing pain in the body. A method is also provided for reducing lipid content of adipocytes in the body.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: June 2, 2015
    Inventor: Heidi Araya
  • Publication number: 20150142086
    Abstract: A method for accelerating the release of neurotransmitters includes a step of radiating light from within a cerebral blood vessel to accelerate the release of the neurotransmitters. An optomedical device includes a main body configured to be introduced into a cerebral blood vessel; a light emitting unit arranged on the main body, the light emitting unit configured to radiate light to accelerate the release of neurotransmitters; and a control unit configured to control a light emitting action of the light emitting unit.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventor: Makoto NARITA
  • Patent number: 9034024
    Abstract: A minimally invasive method for treating varices in especially sensitive areas, including pelvic varices in females, varicoceles, and also oesophageal varices is presented. The method comprises the steps of making a micro incision into the blood vessels of a patient, endoscopically inserting a catheter device into the blood vessel of a patient and advancing the distal end of the catheter to reach the varix or varices. For treatment of male varicocele, insertion is preferably made directly at the testicle. Alternatively, insertion can be made in the femoral vein and advanced using a catheter. Preferably, x-ray, angiography, or other imaging techniques are used to visualize and position the catheter. An optical fiber is then inserted into the catheter and the distal end is advanced to a predetermined point near the varix or varices. Optical fiber distal end is preferably a slim, radial 360 degree emitting fiber end.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: May 19, 2015
    Assignee: Biolitec Pharma Marketing Ltd
    Inventors: Fabio Coluccia, Walter Cecchetti
  • Publication number: 20150133904
    Abstract: Devices and methods for therapeutic photodynamic modulation of neural function in a human. One embodiment of a method in accordance with the technology includes administering a photosensitizer to a human, wherein the photosensitizer preferentially accumulates at nerves proximate a blood vessel compared to non-neural tissue of the blood vessel. The method can further include irradiating the photosensitizer using a radiation emitter positioned within the human, wherein the radiation has a wavelength that causes the photosensitizer to react and alter at least a portion of the nerves thereby providing a therapeutic reduction in sympathetic neural activity. Several embodiments of the technology are useful for disrupting renal nerves, such as renal denervation, for treating hypertension, diabetes, congestive heart failure, and other indications.
    Type: Application
    Filed: December 17, 2014
    Publication date: May 14, 2015
    Inventors: Robert J. Melder, Ayala Hezi-Yamit, Christopher W. Storment, Carol M. Sullivan
  • Patent number: 9023089
    Abstract: The present invention, in one aspect, relates to a system for stimulating neural tissue of a living subject. The system comprises an energy source capable of generating optical energy, a connector having a first end and a second end capable of transmitting optical energy, and a probe operably coupled to the second end of the connector and having an end portion for delivering optical energy to a target neural tissue. In one embodiment, the energy source comprises a tunable laser.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: May 5, 2015
    Assignee: Vanderbilt University
    Inventors: Anita Mahadevan-Jansen, Jonathon D. Wells, E. Duco Jansen, Peter E. Konrad, Changquing C. Kao
  • Patent number: 9023091
    Abstract: A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: May 5, 2015
    Assignee: Novocure Limited
    Inventor: Yoram Palti
  • Patent number: 9023090
    Abstract: A light generating circuit is implanted in a subject's body and aimed at a target region such as a tumor. A photosensitizer is introduced into the target region, and an AC electric field is induced in the region. The field causes the light generating circuit to generate light, which activates the photosensitizer; and at certain field strengths and frequencies, the field itself has a beneficial effect. The beneficial effects of the field and the activated photosensitizer are thereby obtained simultaneously.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: May 5, 2015
    Assignee: Novocure Limited
    Inventor: Yoram Palti
  • Patent number: 9005261
    Abstract: A therapeutic laser with a source of pulsed electromagnetic radiation, a control device for controlling the intensity and/or the duration of the therapeutic laser applied to the tissue, and a detection device for detecting optoacoustic signals triggered by irradiating the living tissue with the pulsed electromagnetic radiation. The therapeutic laser is characterized by an evaluation device that acts on the control device and is used for calculating a degree of quality B(t) from the optoacoustic signals detected by the detection device for individual laser pulses applied to a predetermined laser spot and determining a fit function f(t) at a predetermined point in time ?t1, the fit function f(t) approximating the mean curve of B(t) for 0?t??t1. The intensity and/or the irradiation time of the therapeutic laser is defined by the parameters for the predetermined laser spot, the parameters being determined for the fit function f(t).
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: April 14, 2015
    Assignee: Medizinisches Laserzentrum Luebech GmbH
    Inventor: Ralf Brinkmann
  • Patent number: 8996131
    Abstract: Method and apparatus for infrared-light nerve stimulation-plus-therapeutic-heat (INS-plus-TH) that includes providing a plurality of light sources; providing a plurality of thermally conductive extensions configured to transfer heat generated by the plurality of light sources away from the plurality of light sources; emitting a plurality of infrared-light nerve-stimulation signals toward neural tissue of an animal from the plurality of light sources, wherein the emitted infrared-light nerve-stimulation signals are configured to generate action potentials in the neural tissue, and wherein the emitting of the plurality of infrared-light nerve-stimulation signals includes generating heat; controlling the emitting of the plurality of infrared-light nerve-stimulation signals to generate action potentials in the neural tissue; and transferring the heat generated by the plurality of light sources during the emitting of the plurality of infrared-light nerve-stimulation signals away from the plurality of light sources
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: March 31, 2015
    Assignee: Lockheed Martin Corporation
    Inventors: James M. Owen, Matthew D. Keller, Shuming Yuan
  • Patent number: 8986358
    Abstract: A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: March 24, 2015
    Assignee: Spectracure AB
    Inventors: Sune Svanberg, Johan Axelsson, Johannes Swartling, Ann Johansson, Stefan Andersson-Engels
  • Publication number: 20150080695
    Abstract: Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.
    Type: Application
    Filed: November 4, 2014
    Publication date: March 19, 2015
    Inventors: John A. ROGERS, Dae-Hyeong KIM, Brian LITT, Jonathan VIVENTI
  • Patent number: 8968375
    Abstract: A method of treating a lens of a patient's eye includes generating a light beam, deflecting the light beam using a scanner to form a treatment pattern of the light beam, delivering the treatment pattern to the lens of a patient's eye to create a plurality of cuts in the lens in the form of the treatment pattern to break the lens up into a plurality of pieces, and removing the lens pieces from the patient's eye. The lens pieces can then be mechanically removed. The light beam can be used to create larger segmenting cuts into the lens, as well as smaller softening cuts that soften the lens for easier removal.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: March 3, 2015
    Assignee: Optimedica Corporation
    Inventors: William Culbertson, Barry Seibel, Neil Friedman, Georg Schuele, Phillip Gooding
  • Patent number: 8961580
    Abstract: There are provided an apparatus and a method for blocking abnormal conduction in the cardiac muscle using a photodynamic therapy or for treating arrhythmia. There is provided a catheter ablation apparatus for the treatment of arrhythmia using a photodynamic therapy, comprising a catheter leading a photoradiation unit to an abnormal electrical conduction site or a hyperexcitability occurring site in the cardiac muscle of a test subject in which a photosensitizer is present by administering the photosensitizer beforehand and which causes arrhythmia, means for generating a light ray with which the abnormal electrical conduction site or the hyperexcitability occurring site is irradiated, and means for transmitting the light ray to the abnormal electrical conduction site or the hyperexcitability occurring site, wherein the photosensitizer used is a water-soluble chlorine-based photosensitizer and the light ray used is a light ray having an excitation wavelength equal to that of the photosensitizer.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: February 24, 2015
    Assignee: Keio University
    Inventors: Tsunenori Arai, Shuntaro Hosokawa
  • Patent number: 8936630
    Abstract: Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: January 20, 2015
    Assignee: Medtronic, Inc.
    Inventors: Timothy J. Denison, Kunal Paralikar, Gordon O. Munns, Wesley A. Santa, Peng Cong, Christian S. Nielsen, John D. Norton
  • Patent number: 8936592
    Abstract: Embodiments of the invention are directed to a laser ablation system. In one embodiment, the laser ablation system comprises a shaft, a balloon, a laser fiber and a viewing fiber. The shaft has a proximal end and a distal end. The balloon is attached to the distal end of the shaft, a portion of which is within the balloon. The laser fiber has a distal end comprising a light dispenser that is configured to deliver laser light through the balloon. The viewing fiber is configured to image an interior balloon. In accordance with another embodiment, the laser ablation system comprises a shaft, a balloon and a laser fiber. The shaft has a proximal end and a distal end. The balloon is attached to the distal end of the shaft, which is within the balloon. The balloon includes an inflated state, in which the balloon is shaped to conform to a cavity of a patient. The laser fiber has a distal end comprising light dispenser that is configured to deliver laser light through the balloon.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: January 20, 2015
    Assignee: AMS Research Corporation
    Inventors: Michael T. Beck, Edouard A. Koullick, Robert E. Lund, Douglas L. Evans, Samuel L. Will, Stuart F. Watson, Hyun Wook Kang, Justin M. Crank, Somany Dy, Micah D. Thorson
  • Publication number: 20150018598
    Abstract: A neurostimulation patch is affixed to a patient's skin (e.g., via a medical skin adhesive) and provides stimulation energy for an implanted lead. The patch may be used for SCS trials or other applications where is it desirable to avoid implanting a stimulation device within a patient. Circuitry in the patch generates stimulation signals and couples these signals to the implanted lead. The signals may be coupled to the lead via a direct physical connection or via a wireless connection. In some embodiments, the neurostimulation patch is configured in a manner that enables the patch to be placed immediately above the puncture site where an associated percutaneous lead passes through a patient's skin, thereby protecting the puncture site and facilitating secure routing of the lead.
    Type: Application
    Filed: July 10, 2013
    Publication date: January 15, 2015
    Inventors: Yelena Nabutovsky, Melanie Goodman Keiser, Gene A. Bornzin
  • Publication number: 20150018901
    Abstract: A neural prosthetic device can selectively deliver light to different cortical layers, at different depths, in the brain. The device includes LEDs and corresponding waveguides that can extend into the brain. At least two of the waveguides have different lengths. The neural prosthetic device or other devices can be manufactured by changing the hydrophilicity or lyophilicity of a portion of a substrate layer, then depositing uncured polymer on the treated portion of the substrate layer. The uncured polymer flows under the influence of surface tension to form a volume. The volume is shaped as a dome that extends laterally to a boundary between the treated and untreated portions. The polymer is cured in discrete regions through the substrate layer. The discrete regions extend longitudinally from the substrate layer to a curved surface of the dome. The uncured portion of the polymer is removed. The cured regions form the waveguides.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 15, 2015
    Inventors: Wen Li, Ki Yong Kwon
  • Publication number: 20150012072
    Abstract: A system for irradiation of a vascular space and its contents is presented. An adapter device having a vascular access end and an optical interface end can include a waveguide affixed within a waveguide lumen and extending outwardly through the vascular access end. The optical interface end includes a tapered terminus configured to engage with a cavity of an optical connector adapter, creating an optical interface between the waveguide of the adapter device and a waveguide of a light or radiation source. The adapter device enables the simultaneous administration of radiation and exogenous fluids to a patient while maintaining the optical interface isolated from any fluids.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Inventors: Scot Johnson, Michael Harter, Victor Josef Scheeren
  • Patent number: 8929978
    Abstract: Methods and devices related to the treatment of diseases using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring system 1, Ring system 2, Ring system 3, or Ring system 4. Methods of treating disease with phototherapy are also described.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: January 6, 2015
    Assignee: Nitto Denko Corporation
    Inventors: Sazzadur Rahman Khan, Shijun Zheng, Amane Mochizuki, Liping Ma
  • Patent number: 8910638
    Abstract: In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used for this neural screening, including (a) iterative subdivision, (b) serial search, and (c) combinatorial. To perform this neural screening, an array of optical fibers (or an array of waveguides) is inserted into the brain. Alternately, the array is positioned adjacent to the brain. Each fiber or waveguide in the array is coupled to a light source (LED or laser). The brain has been previously sensitized to light, using genetically encoded optical neural control reagents, which are delivered either using viruses or via transgenic means. In the screening, the array is used to optically perturb the brain. For example, the neurons of the brain may be activated by one color of light, and/or silenced by another color of light.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: December 16, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward Boyden, Jacob Bernstein, Christian Wentz, Giovanni Talei Franzesi, Michael Baratta, Brian Allen, Anthony Zorzos, Jorg Scholvin, Clifton Fonstad
  • Publication number: 20140358199
    Abstract: The present invention is a portable non-invasive apparatus, system, and method for performing light therapy or photobiomodulation upon the brain tissues through the nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. In marked difference to conventionally known therapeutic procedures, the present invention utilizes the intranasal pathway as the point of anatomic access; and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo. In this manner, the present invention utilizes light energy of specified wavelengths, coherency, and pulsed mode to achieve therapeutic outcomes.
    Type: Application
    Filed: June 4, 2013
    Publication date: December 4, 2014
    Inventor: Teng Lew Lim
  • Patent number: 8900284
    Abstract: This invention relates to an implantable device that delivers an effective amounts of red light to the substantia nigra as a treatment for Parkinson's Disease (PD).
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: December 2, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Thomas M. DiMauro, Mohamed Attawia, Chantal Holy, Sean Lilienfeld, Jeffrey K. Sutton, Michael Ward
  • Patent number: 8894696
    Abstract: A light emitting device to awaken or alert an animal by stimulating the Suprachiasmatic Nucleus in the brain to suppress melatonin secretion and change gene expression in the brain. The device can be programmed for an initiation time, color of light, brightness, frequency of pulsating light, and level of gradual intensity. It has the advantage of being silent, does not to disturb other people sleeping in the same room and user is more cognitively alert.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: November 25, 2014
    Inventor: Katherine L Hurst
  • Patent number: 8886278
    Abstract: An optical stimulation probe has a probe body inserted into a subject, an electrode formed on the probe body and collecting a response signal from the subject, a light irradiator attached to the probe body and irradiating an optical signal and a reflecting surface formed on the probe body on the path of the optical signal. The reflecting surface changes the course of the optical signal irradiated from the light irradiator to the direction where the electrode faces by reflecting the optical signal. The electrode may be formed on a side portion of the probe body such that it faces a direction perpendicular to a length direction of the probe body, and the optical signal reflected by the reflecting surface may travel along a direction perpendicular to the length direction of the probe body, such that the direction where the electrode faces and the direction along which the reflected optical signal travels are parallel to each other.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: November 11, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: JinSeok Kim, Eui-Sung Yoon, Hyun-Joon Shin, Jun-Kyo Francis Suh
  • Publication number: 20140330196
    Abstract: A device to stimulate a scalp comprising an array of stimulating elements adapted to pierce the skin of the scalp no deeper than a thickness of a dermis, wherein the stimulating elements are arranged along a circumference of at least one wheel and the wheel is adapted to roll over the scalp.
    Type: Application
    Filed: December 6, 2012
    Publication date: November 6, 2014
    Inventors: Dov Ingman, Erez Manor
  • Publication number: 20140324138
    Abstract: In exemplary implementations of this invention, an implant device is wholly or partially implanted in a mammal. The implant device includes an antenna, circuitry, a supercapacitor, one or more light sources, and an array of optical fibers or light guides. The antenna and circuitry receive energy by wireless transmission from an external transmit coil. The supercapacitor stores at least a portion of the energy and provides power to one or more light sources. The array of optical fibers or light guides deliver light from the light sources to living tissue of a mammal. The tissue includes light-sensitive, heterologously expressed proteins. The light affects the light-sensitive proteins, triggering a change in all or part of the tissue, such as a change in voltage, pH or a change in function.
    Type: Application
    Filed: June 13, 2014
    Publication date: October 30, 2014
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Christian Wentz, Jacob Bernstein, Edward Boyden
  • Patent number: 8852254
    Abstract: Apparatus and methods for treating psychiatric disorders, mood disorders and circadian rhythm disorders with a multi-stage light protocol are disclosed. The presently disclosed multi-stage light protocol provides a synergistic treatment including up to 4 types of therapies: bright light therapy, extended sleep deprivation therapy, dawn simulation therapy and short to medium wavelength light therapy. According to some embodiments, the first stage of the protocol includes a first time window of 20 minutes during which, for a majority of the time, the light intensity is between 50 lux and 2000 lux. According to some embodiments, the second stage of the protocol includes a second time window of at least 90 minutes during which, for every 10 minute period within the second time window, for a majority of the time, the light intensity is exceeds 100 lux.
    Type: Grant
    Filed: February 19, 2006
    Date of Patent: October 7, 2014
    Inventor: Lucian Moscovici
  • Patent number: 8845705
    Abstract: An output assembly is sized for placement in the middle and inner ear, such that removal of bone can be decreased. The output assembly may comprise at least one photo detector, a demultiplexer and an optical array sized to pass through an incision in the eardrum. An input transducer assembly is configured to transmit a multiplexed optical signal to the output assembly. The input assembly can be configured to transmit the multiplexed optical signal through the eardrum, such that tissue removal can be decreased and the device can be placed without removal of bone, for example. The multiplexed optical signal may comprise a pulse width modulated signal so as to decrease the effect of non-linearities of the light source and light detector and provide quality sound to the user.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: September 30, 2014
    Assignee: EarLens Corporation
    Inventors: Rodney C. Perkins, Sunil Puria
  • Patent number: 8845703
    Abstract: Red light implants for delivering red light to spinal implants to enhance osteointegration.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: September 30, 2014
    Assignee: DePuy Synthes Products, LLC
    Inventors: Mohamed Attawia, Thomas M DiMauro, Jeffrey K Sutton
  • Publication number: 20140288458
    Abstract: A neural probe (10) is provided for in vivo communication with biological tissue, including stimulating neurons and/or recording neural electrical activity. The probe (10) may be constructed so that the immune response by the biological tissue in which the device is implanted is reduced over known implantable probes. The probe (10) can be constructed with a tip (16) that has a branched configuration, with electrodes (24) located along each of the branches (20). A biodegradable coating (18) is disposed over at least the tip (16) of the probe (10) to provide the probe (10) with sufficient integrity for insertion into the biological tissue and to degrade after insertion. The biodegradable coating (18) can have an anti-inflammatory drug or other bioagent distributed therein for localized release of the bioagent to further reduce the immune response.
    Type: Application
    Filed: June 4, 2012
    Publication date: September 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Euisik Yoon, Fan Wu
  • Patent number: 8836939
    Abstract: A probe detachably connected to an optical measurement apparatus includes: a fiber that emits light by the optical measurement apparatus, and outputs reflected light and/or scattered light from an object to be measured; a covering member that covers a side face of the fiber; a cap that covers a distal end of the probe; a standard object that is provided on a surface of the cap facing the distal end of the fiber and that is used in calibration measurement by light emitted from the distal end of the fiber; an adhesive member that adheres the cap to the distal end of the probe and is made of an adhesive material; a heat-generating portion that generates heat to be applied to the adhesive member; and a thermal conduction portion that conducts heat that decreases the adhesive strength of the adhesive material with respect to the covering member.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: September 16, 2014
    Assignee: Olympus Medical Systems Corp.
    Inventor: Kazuhiro Gono
  • Patent number: 8834546
    Abstract: Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: September 16, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Jin Hyung Lee
  • Patent number: 8821560
    Abstract: Disclosed are an optical stimulation probe structure having a probe body inserted into a subject, a fixing body that fixes the probe body and a light radiator that transmits an optical signal to the probe body, wherein the probe body is made of an optical transmission material capable of transmitting an optical signal, such that the optical signal transmitted from the light radiator is transmitted through the probe body to the subject, and a method for manufacturing the same.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: September 2, 2014
    Assignee: Korea Institute of Science and Technology
    Inventors: Eui Sung Yoon, Il Joo Cho, Jin Seok Kim, Kyoung Hwan Na, Hyung Dal Park
  • Publication number: 20140243937
    Abstract: Red light-emitting implants for treating a spine.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 28, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventors: Thomas M. DiMauro, Mohamed Attawia, Jeffrey K. Sutton
  • Patent number: 8814921
    Abstract: Methods and systems for modifying tissue use a pressurized fluid stream carrying coherent light energy. The methods and systems may be used for resecting and debulking soft and hard biological tissues. The coherent light is focused within a stream of fluid to deliver energy to the tissue to be treated.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: August 26, 2014
    Assignee: AquaBeam LLC
    Inventors: Nikolai Aljuri, Rodney C. Perkins
  • Publication number: 20140235942
    Abstract: Process and device for directly medicinally treating interior tissue during or after intubation of a patient by passing medicinal radiant energy transversely through the intubation device to irradiate the internal patient tissue for promoting healing or for an antimicrobial effect. The invention is useful in conjunction with endoscopies and catherizations, such as urinary catherization, gastric and pulmonary endoscopies, and the like procedures. The process and device can also provide liquid flow and/or vision.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Applicant: PERCUVISION, LLC
    Inventors: Ake A. Hellstrom, Errol O. Singh, Allen Stock
  • Publication number: 20140236270
    Abstract: An improved prosthesis and method for stimulating vision nerves to obtain a vision sensation that is useful for the patient that has lost vision due to age-related macular degeneration (AMD) and retinitis pigmentosa (RP) and other diseases. The present invention utilizes infrared light to cause action potentials in the retinal nerves similar to those which result from rods and cones stimulated by visible light in healthy retinas. In some embodiments, the invention provides a pathway or “image pipe” for transmitting a stimulation pattern of infrared light from an external stimulator array through the eye and focusing the stimulation pattern of infrared light on the retina, especially the fovea. Some embodiments provide improved resolution down to a group of nerves, or even the individual nerve level, with sufficient energy density so as to cause a desired action potential.
    Type: Application
    Filed: April 29, 2014
    Publication date: August 21, 2014
    Applicant: Lockheed Martin Corporation
    Inventors: Michael E. Friend, Yongdan Hu
  • Publication number: 20140228901
    Abstract: An implantable stimulation device is described which includes a flexible carrier member for implantation adjacent to target neural tissue. Carrier wires are embedded within the carrier member for conducting electrical signals. At least one active interface device also is within the carrier member and includes a hermetically sealed device housing without penetration by any electrical conductor, an active interface element within the device housing, an inductive link arrangement providing an electrical connection between the active interface element and a terminal end of one of the carrier wires, and an outer interface surface adjacent to the target neural tissue that provides a communication link between the adjacent target neural tissue and the active interface element.
    Type: Application
    Filed: February 14, 2013
    Publication date: August 14, 2014
    Applicant: MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH
    Inventor: MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH
  • Publication number: 20140207214
    Abstract: Apparatus and methods are disclosed for treating allergic rhinitis (seasonal and perennial hay fever), by application of flash lamp radiation. The nasal cavity can be illuminated in a safe and effective manner, with non-coherent light from a flash-lamp or other suitable source. This illumination can be accomplished in any suitable manner, including by use of a handheld device. Such handheld embodiments may contain a power source (battery or AC), control circuitry, light source (flash-lamp or diode laser), lens (focusing or non-focusing), light filter, and/or fiber-optic for delivering light to the nasal cavity. Embodiments include using any suitable light energy, such as visible light in the red wavelengths with a power output of 1 to 10 Joules per cm2. The device can be pre-programmed to deliver a specified amount of light in a specified amount of time using multiple pulses (in the case of a flash lamp) or a continuous wave (in the case of a diode laser).
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Inventors: Richard Oberreiter, Jan Enemaerke, Denis Bouboulis
  • Publication number: 20140188198
    Abstract: A device for treating disease has a hypodermic needle having a hollow shaft and an insertion tip, at least one fiberoptic filament extending through the needle to the insertion tip, and a UV light source connected to the fiberoptic filament. The UV light source is adapted to transmit UV light at a wavelength of 280-100 nm. The hypodermic needle is inserted into a patient until the insertion tip is located in an area to be treated, and the UV light is supplied to the at least one fiberoptic filament, so that the light travels along the filament to the area to be treated.
    Type: Application
    Filed: July 30, 2013
    Publication date: July 3, 2014
    Inventor: Donald SPECTOR